From 4b60c20509bd85eb85cd35a13febebdf4c58b155 Mon Sep 17 00:00:00 2001
From: Ivan Pavlovich <ivan.pavlovic@hes-so.ch>
Date: Thu, 13 Mar 2025 21:15:20 +0100
Subject: [PATCH] Modified dataset creation script to take text length into
count and recreated dataset with 200 articles in each length category
---
.../__pycache__/pubmedApi.cpython-313.pyc | Bin 7064 -> 6947 bytes
dataSources/PubMed/pubmedApi.py | 4 +-
testModel/__pycache__/metrics.cpython-313.pyc | Bin 1571 -> 1652 bytes
testModel/__pycache__/utils.cpython-313.pyc | Bin 1038 -> 4428 bytes
testModel/dataset/cancer.json | 2375 ++++++++------
.../dataset/cardiovascular_diseases.json | 2743 ++++++++--------
.../dataset/chronic_respiratory_disease.json | 2658 +++++++--------
testModel/dataset/create_test_data.py | 95 +-
testModel/dataset/diabetes.json | 2508 ++++++++-------
testModel/dataset/diabetes_type_1.json | 2864 +++++++++--------
testModel/dataset/diabetes_type_2.json | 2863 ++++++++--------
testModel/dataset/mental_health.json | 2640 ++++++++-------
.../dataset/non-communicable_diseases.json | 2391 ++++++++++++++
.../dataset/noncommunicable_diseases.json | 2254 -------------
testModel/{old => }/test_articles_len.py | 13 +-
15 files changed, 12352 insertions(+), 11056 deletions(-)
create mode 100644 testModel/dataset/non-communicable_diseases.json
delete mode 100644 testModel/dataset/noncommunicable_diseases.json
rename testModel/{old => }/test_articles_len.py (88%)
diff --git a/dataSources/PubMed/__pycache__/pubmedApi.cpython-313.pyc b/dataSources/PubMed/__pycache__/pubmedApi.cpython-313.pyc
index 8efc23ccdcf2d6565397f9fe5b909684064402a2..2b6898c16a135b047d0a3d8a3b5d360a8a9eb13e 100644
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diff --git a/dataSources/PubMed/pubmedApi.py b/dataSources/PubMed/pubmedApi.py
index d41b83d5f..28c194590 100644
--- a/dataSources/PubMed/pubmedApi.py
+++ b/dataSources/PubMed/pubmedApi.py
@@ -74,7 +74,7 @@ def getPubmedData(term, date_min, date_max, nb_items = -1, debug = False, store
for entrie in obj[key]:
if "MedlineCitation" in entrie:
- print("---------------------------------------------------------")
+ # print("---------------------------------------------------------")
if "MeshHeadingList" in entrie["MedlineCitation"]:
data = {}
@@ -129,8 +129,6 @@ def getPubmedData(term, date_min, date_max, nb_items = -1, debug = False, store
}
break
- print(data)
-
if debug:
print(f"Index: {obj[key].index(entrie)}")
print(f"PMID: {data["PMID"]}")
diff --git a/testModel/__pycache__/metrics.cpython-313.pyc b/testModel/__pycache__/metrics.cpython-313.pyc
index 4ad89e5031f2ea7dd65481aec4beb642164c40e1..aabc6b292b1d019797cd5429382ab3481e71baf9 100644
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diff --git a/testModel/__pycache__/utils.cpython-313.pyc b/testModel/__pycache__/utils.cpython-313.pyc
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diff --git a/testModel/dataset/cancer.json b/testModel/dataset/cancer.json
index 783ccbd67..fbb749c1d 100644
--- a/testModel/dataset/cancer.json
+++ b/testModel/dataset/cancer.json
@@ -15,7 +15,12 @@
"Melanoma",
"Gene Expression Regulation, Neoplastic",
"Neoplasms"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39738156",
@@ -32,7 +37,12 @@
"Genome, Human",
"Theranostic Nanomedicine",
"Deep Learning"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39738052",
@@ -56,7 +66,12 @@
"Treatment Outcome",
"Electronic Health Records",
"Lung Neoplasms"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39738026",
@@ -79,7 +94,12 @@
"Carcinoma, Pancreatic Ductal",
"DNA Repair",
"Mutation"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39738003",
@@ -106,7 +126,12 @@
"Antibodies, Monoclonal",
"Mice, Inbred BALB C",
"Combined Antibody Therapeutics"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737979",
@@ -135,7 +160,12 @@
"Interferon-gamma",
"Interleukin-12",
"Gasdermins"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737928",
@@ -155,7 +185,35 @@
"Cancer Vaccines",
"Alleles",
"Computational Biology"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39737681",
+ "Title": "BioEssays : news and reviews in molecular, cellular and developmental biology",
+ "ArticleTitle": "Epithelial Polarity Loss and Multilayer Formation: Insights Into Tumor Growth and Regulatory Mechanisms.",
+ "Abstract": "Epithelial tissues serve as critical barriers in metazoan organisms, maintaining structural integrity and facilitating essential physiological functions. Epithelial cell polarity regulates mechanical properties, signaling, and transport, ensuring tissue organization and homeostasis. However, the barrier function is challenged by cell turnover during development and maintenance. To preserve tissue integrity while removing dying or unwanted cells, epithelial tissues employ cell extrusion. This process removes both dead and live cells from the epithelial layer, typically causing detached cells to undergo apoptosis. Transformed cells, however, often resist apoptosis, leading to multilayered structures and early carcinogenesis. Malignant cells may invade neighboring tissues. Loss of cell polarity can lead to multilayer formation, cell extrusion, and invasion. Recent studies indicate that multilayer formation in epithelial cells with polarity loss involves a mixture of wild-type and mutant cells, leading to apical or basal accumulation. The directionality of accumulation is regulated by mutations in polarity complex genes. This phenomenon, distinct from traditional apical or basal extrusion, exhibits similarities to the endophytic or exophytic growth observed in human tumors. This review explores the regulation and implications of these phenomena for tissue biology and disease pathology.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cell Polarity",
+ "Animals",
+ "Neoplasms",
+ "Epithelial Cells",
+ "Apoptosis",
+ "Signal Transduction"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737671",
@@ -174,13 +232,18 @@
"Nitrogen",
"Structure-Activity Relationship",
"Triazoles"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737633",
"Title": "Journal of pediatric hematology/oncology",
"ArticleTitle": "Assessment of Antibody Levels and Vaccine-induced Serologic Responses After Completion of Cancer Treatment in Pediatric Patients: A 6-Year Experience in Turkey on HAV, HBV, VZV, and MMR Vaccinations.",
- "Abstract": "Post-treatment serological vaccine responses in children were lower than anticipated despite multiple doses. Given the potential need for periodic serological assessments and booster vaccinations, long-term follow-ups are planned.",
+ "Abstract": "Childhood cancer treatment disrupts vaccination schedules and weakens or eliminates vaccine-induced immunity. In addition, post-treatment vaccine responses vary. This study aimed to assess post-treatment serum antibody levels and vaccine responses in children.Pediatric patients treated at Hacettepe University between years 2015 and 2020, achieved remission after chemotherapy for lymphoma and solid tumors were included. Post-treatment vaccination status, serum antibody levels for hepatitis A (HAV), hepatitis B (HBV), varicella-zoster (VZV), measles-mumps-rubella (MMR), and changes in vaccine responses were retrospectively analyzed.The study included 533 patients. Post-treatment seronegativity rates were: measles (83.5%), HAV (64%), rubella (60.1%), HBV (48.5%), VZV (43.3%), and mumps (28%). Post-treatment antibody loss was observed for measles (47.1%), HAV (31.9%), HBV (31.4%), mumps (28.6%), VZV (21.7%), and rubella (11.4%). Seropositivity after 1 vaccine dose was seen with HAV (83.6%), rubella (82.9%), HBV (81.4%), VZV (63.5%), mumps (45.4%), and measles (33.3%). Seropositivity after 2 vaccine doses was achieved with HAV (98.8%), VZV (84.6%), rubella (80%), HBV (80%), measles (32.2%), and mumps (36.2%).Post-treatment serological vaccine responses in children were lower than anticipated despite multiple doses. Given the potential need for periodic serological assessments and booster vaccinations, long-term follow-ups are planned.",
"Predictions": [
"Cancer"
],
@@ -202,7 +265,12 @@
"Chickenpox Vaccine",
"Hepatitis A Vaccines",
"Follow-Up Studies"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737568",
@@ -221,7 +289,12 @@
"Protein Interaction Maps",
"Protein Interaction Mapping",
"Gene Regulatory Networks"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737564",
@@ -241,7 +314,12 @@
"Genomics",
"Lung Neoplasms",
"Biomarkers, Tumor"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737563",
@@ -258,7 +336,12 @@
"Machine Learning",
"Neoplasms",
"Computational Biology"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737507",
@@ -279,7 +362,12 @@
"Incidence",
"Aged, 80 and over",
"Global Burden of Disease"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737190",
@@ -300,13 +388,18 @@
"Drugs, Chinese Herbal",
"Immunity, Innate",
"Autoimmune Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737177",
"Title": "Frontiers in immunology",
"ArticleTitle": "Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types.",
- "Abstract": "BCAP31 has the potential to serve as a biomarker for cancer immunology, particularly in relation to immune cell infiltration, and as an indicator of poor prognosis. These findings provide a new perspective that could inform the development of more targeted cancer therapy strategies.",
+ "Abstract": "B-cell receptor-associated protein 31 (BCAP31) is a widely expressed transmembrane protein primarily located in the endoplasmic reticulum (ER), including the ER-mitochondria associated membranes. Emerging evidence suggests that BCAP31 may play a role in cancer development and progression, although its specific effects across different cancer types remain incompletely understood.The raw data on BCAP31 expression in tumor and adjacent non-tumor (paracancerous) samples were obtained from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) and UCSC databases. We also examined the association between BCAP31 expression and clinicopathological factors. Using the Cox proportional hazards model, we found that high BCAP31 levels were linked to poor prognosis. To further explore BCAP31's role, we analyzed the relationship between copy number variations (CNV) and BCAP31 mRNA expression using data from The Cancer Genome Atlas (TCGA). Additionally, the association between BCAP31 expression and signature pathway scores from the MsigDB database provided insights into the tumor biology and immunological characteristics of BCAP31.We assessed the relationship between tumor immune infiltration and BCAP31 expression using the TIMER2 and ImmuCellAI databases. The ESTIMATE computational method was employed to estimate the proportion of immune cells infiltrating the tumors, as well as the stromal and immune components, based on TCGA data. To investigate drug sensitivity in relation to BCAP31 expression, we utilized GDSC2 data, which included responses to 198 medications. We explored the relationship between BCAP31 gene expression and response to immunotherapy. Additionally, the study involved culturing KYSE-150 cells under standard conditions and using siRNA-mediated knockdown of BCAP31 to assess its function. Key experiments included Western blotting (WB) to confirm BCAP31 knockdown, MTT assays for cell proliferation, colony formation assays for growth potential, Transwell assays for migration and invasion, and wound healing assays for motility. Additionally, immunohistochemistry (IHC) was performed on tumor and adjacent normal tissue samples to evaluate BCAP31 expression levels.BCAP31 was found to be significantly overexpressed in several prevalent malignancies and was associated with poor prognosis. Cox regression analysis across all cancer types revealed that higher BCAP31 levels were predominantly linked to worse overall survival (OS), disease-free interval (DFI), disease-specific survival (DSS), and progression-free interval (PFI). In most malignancies, increased BCAP31 expression was positively correlated with higher CNV. Additionally, BCAP31 expression was strongly associated with the tumor microenvironment (TME), influencing the levels of infiltrating immune cells, immune-related genes, and immune-related pathways. Drug sensitivity analysis identified six medications that showed a significant positive correlation with BCAP31 expression. Furthermore, BCAP31 expression impacted the outcomes and prognosis of cancer patients undergoing immune therapy. The functional assays demonstrated that BCAP31 knockdown in KYSE-150 cells significantly inhibited cell migration, invasion, and proliferation while enhancing colony formation ability. WB and immunohistochemistry analyses confirmed elevated BCAP31 expression in tumor tissues compared to adjacent normal tissues in esophageal cancer, lung adenocarcinoma, and gastric adenocarcinoma.BCAP31 has the potential to serve as a biomarker for cancer immunology, particularly in relation to immune cell infiltration, and as an indicator of poor prognosis. These findings provide a new perspective that could inform the development of more targeted cancer therapy strategies.",
"Predictions": [
"Cancer"
],
@@ -324,13 +417,18 @@
"Tumor Microenvironment",
"Lymphocytes, Tumor-Infiltrating",
"DNA Copy Number Variations"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736787",
"Title": "Journal of hematology & oncology",
"ArticleTitle": "Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study.",
- "Abstract": "ClinicalTrials.gov Identifier: NCT04085185.",
+ "Abstract": "Co-inhibition of immune checkpoints lymphocyte-activation gene 3 (LAG-3) and PD-1 is believed to enhance cancer immunotherapy through synergistic effects. Herein, we evaluate the safety and efficacy of IBI110 (anti-LAG-3 antibody) with sintilimab (an anti-PD-1 antibody) in Chinese patients with advanced solid tumors.In this open-label phase I study, phase Ia dose escalation of IBI110 monotherapy and phase Ib combination dose escalation of IBI110 plus sintilimab were conducted in patients with advanced solid tumors. Additionally, phase Ib combination dose expansion of IBI110 plus sintilimab and chemotherapy was conducted in previously untreated, advanced squamous non-small cell lung cancer (sqNSCLC) and HER-2 negative gastric cancer (GC). In phase Ia dose escalation, patients received IBI110 monotherapy at 0.01/0.1/0.3/1/3/10/20\u00a0mg/kg Q3W. In phase Ib dose escalation, patients received IBI110 at 0.3/0.7/1.5/3/5/8/10\u00a0mg/kg Q3W plus sintilimab 200\u00a0mg Q3W. In phase Ib combination dose expansion, patients received IBI110 at recommended phase 2 dose (RP2D) plus sintilimab 200\u00a0mg Q3W and chemotherapy. The primary endpoints were safety, tolerability and efficacy including objective response rate (ORR), disease control rate (DCR), duration of response (DoR), progression-free survival (PFS) assessed by RECIST v1.1 and overall survival (OS). The secondary endpoints included pharmacokinetics, pharmacodynamics and immunogenicity.In phase Ia dose escalation (n\u2009=\u200928), treatment-related adverse events (TRAEs) occurred in 67.9% patients and grade\u2009\u2265\u20093 TRAEs occurred in 21.4% patients. In phase Ib combination dose escalation (n\u2009=\u200945), TRAEs occurred in 75.6% patients and grade\u2009\u2265\u20093 TRAEs occurred in 22.2% patients. No dose-limiting toxicity (DLT) was observed. The most common TRAE was anemia (17.9%, including 3.6% \u2265 G3) in phase Ia dose escalation of IBI110 monotherapy (n\u2009=\u200928), aspartate aminotransferase increased (28.9%, all G1-G2) in phase Ib dose escalation of IBI110 plus sintilimab (n\u2009=\u200945), anemia (70.0%, all G1-G2) in phase Ib dose expansion in sqNSCLC (n\u2009=\u200920), and neutrophil count decreased (64.7%, including 17.6%\u2265 G3) in phase Ib dose expansion in GC (n\u2009=\u200917). The RP2D of IBI110 was determined at 200\u00a0mg (3\u00a0mg/kg) Q3W. ORR in phase Ia/Ib dose escalation was 3.6% with IBI110 monotherapy and 14% with IBI110 plus sintilimab. In phase Ib combination dose expansion of IBI110 plus sintilimab and chemotherapy, unconfirmed and confirmed ORR in sqNSCLC (n\u2009=\u200920) was 80.0% (95% CI, 56.3-94.3) and 75.0% (95% CI, 50.9-91.3), respectively and in GC (n\u2009=\u200917) was 88.2% (95% CI, 63.6-98.5) and 70.6% (95% CI, 44.0-89.7), respectively.IBI110 monotherapy and in combination with sintilimab were well-tolerated in Chinese patients with advanced solid tumors. Encouraging efficacy of IBI110 in combination with sintilimab and chemotherapies was observed in sqNSCLC and GC.ClinicalTrials.gov Identifier: NCT04085185.",
"Predictions": [
"Cancer"
],
@@ -348,13 +446,18 @@
"Neoplasms",
"Immune Checkpoint Inhibitors",
"Antigens, CD"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736754",
"Title": "Health research policy and systems",
"ArticleTitle": "A novel social-network-analysis-based approach for analyzing complex network of actors involved in accessibility of anti-cancer medications\u00a0in Iran.",
- "Abstract": "This study highlights the importance of complex relationships among various actors and proposes a novel SNA-based approach to analyse them. Regarding the main steps of the proposed approach and the findings, it is imperative for pharmaceutical policy plans to involve a diverse group of experts from the beginning, prioritizing the preferences of stakeholders, and providing a patient-centred approach to prevent the worsening of resource shortages.",
+ "Abstract": "The access to anti-cancer medications is influenced by policies formed via the convergence of various stakeholders. The aim of this study is to identify and analyse the stakeholders involved in formulating and implementing policies related to the accessibility of anti-cancer medications in Iran and their interactions that are relevant to the outcomes of these policies for the first time.To achieve the objectives, a novel multistage social network analysis (SNA)-based approach that includes three phases is proposed. First, the actors were identified by a team consisting of multidisciplinary knowledgeable experts through 15 comprehensive interviews. Then, the influence relationships of these actors were comprehensively analysed through in-depth interviews with nine key informants involved in pharmaceutical policies through a structured questionnaire. Finally, a novel network of actors was determined accordingly, and a SNA-based approach proposed to reveal the intrinsic roles and various aspects of the importance of the network's actors.The study identified a total of 45 actors, which were then classified into 4 categories on the basis of their public or private nature and their foreign or domestic origin. This established network helped in creating a comprehensive view of the main actors, and can help policymakers to solve the problems related to access to anti-cancer medications more effectively and prevent the creation of these problems in the future. In this way, the network identified specific actors that can benefit from increased attention and dialogue. The computational results revealed that the Iran Food and Drug Administration (IFDA), Pharmaceutical Importer Companies (PharIc) and Pharmaceutical Manufacturing Companies (PharMC) were highly important actors in terms of their connectivity to other actors. Additionally, law enforcement agencies (LEA) have shown limited effectiveness within this network.This study highlights the importance of complex relationships among various actors and proposes a novel SNA-based approach to analyse them. Regarding the main steps of the proposed approach and the findings, it is imperative for pharmaceutical policy plans to involve a diverse group of experts from the beginning, prioritizing the preferences of stakeholders, and providing a patient-centred approach to prevent the worsening of resource shortages.",
"Predictions": [
"Cancer"
],
@@ -371,13 +474,18 @@
"Surveys and Questionnaires",
"Social Networking",
"Drug Industry"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736712",
"Title": "BMC medical education",
"ArticleTitle": "Patient-centered interprofessional education in cancer care: a systematic scoping review.",
- "Abstract": "The findings indicate that patient-centered IPE programs effectively promote interprofessional collaboration and enhance clinical competencies in cancer care. Future research should focus on long-term evaluations, address systemic barriers, expand geographical scope, and utilize standardized evaluation frameworks to further improve the design and implementation of patient-centered IPE programs in cancer care.",
+ "Abstract": "Cancer remains a critical global health issue requiring a comprehensive interdisciplinary approach for effective treatment. Interprofessional education (IPE) is essential for overcoming barriers to collaboration among healthcare professionals and fostering efficient teamwork in cancer care.This systematic scoping review aims to explore the role of IPE in enhancing interprofessional collaboration within cancer care by mapping and synthesizing the implementation, impact, and evaluation strategies of patient-centered IPE programs in this field.A comprehensive search was conducted across seven databases, including CENTRAL, CINAHL, Embase, MEDLINE, PsycInfo, Scopus, and Web of Science, from their inception to January 2024. Grey literature was also sought through online sources and by contacting relevant organizations. Data were extracted and synthesized narratively following a standardized protocol.Seven studies met the inclusion criteria, highlighting various educational methods such as web-based platforms, face-to-face interactions, experiential learning, and simulation-based training. Patient-centered IPE programs notably improved interprofessional collaboration, communication, knowledge, and self-confidence among healthcare professionals. Additionally, several programs led to concrete changes in clinical practice and institutional policies. Evaluation strategies primarily utilized established frameworks such as Kirkpatrick's model and Moore's outcome levels to assess multiple layers of outcomes, including participant satisfaction, knowledge acquisition, competence, and behavior change.The findings indicate that patient-centered IPE programs effectively promote interprofessional collaboration and enhance clinical competencies in cancer care. Future research should focus on long-term evaluations, address systemic barriers, expand geographical scope, and utilize standardized evaluation frameworks to further improve the design and implementation of patient-centered IPE programs in cancer care.",
"Predictions": [
"Cancer"
],
@@ -390,40 +498,18 @@
"Patient Care Team",
"Health Personnel",
"Cooperative Behavior"
- ]
- },
- {
- "PMID": "39736689",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
- "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
- "Predictions": [
- "Diabetes",
- "Cancer",
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Humans",
- "Cardiovascular Diseases",
- "Neoplasms",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
- "Longitudinal Studies",
- "Aged",
- "Proportional Hazards Models",
- "Diabetes Mellitus",
- "Risk Factors",
- "Cardiometabolic Risk Factors",
- "Cohort Studies"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736601",
"Title": "BMC public health",
"ArticleTitle": "Research on health information avoidance behavior and influencing factors of cancer patients-an empirical analysis based on structural equation modeling.",
- "Abstract": "Sociodemographic factors influencing cancer patients' health information avoidance behaviors include per capita monthly household income, occupation, treatment modality, number of years of smart device use, and number of hours per week reading health information. Self-efficacy and negative emotions mediated the analytic model of health information avoidance behavior in cancer patients, respectively.",
+ "Abstract": "To explore the health information avoidance behaviors and influencing factors of cancer patients, and to construct a structural equation model to analyze the mediating roles of self-efficacy and negative emotions in the process of generating health information avoidance behaviors of cancer patients.A face-to-face electronic questionnaire was used to collect data. Applying a chi-square test and multivariate logistic regression model to analyze the role of different socio-demographic factors in influencing health information avoidance behavior of cancer patients; applying structural equation modeling to analyze the role mechanism of health information avoidance behavior of cancer patients.The results of multivariate logistic regression analysis revealed that socio-demographic factors of per capita monthly household income, marital status, occupation, treatment modality, years of use of smart devices, and weekly hours of reading health information had an impact on health information avoidance behavior of cancer patients. All fit indices of the structural equation model were within acceptable limits,(CMIN/DF\u2009=\u20092.285,RMSEA\u2009=\u20090.045,CFI\u2009=\u20090.949,IFI\u2009=\u20090.949,RFI\u2009=\u20090.902,TLI\u2009=\u20090,942).The results of the mediating effect found that self-efficacy mediated the paths of information overload and privacy concern to health information avoidance behavior, respectively; negative emotions mediated the paths of information overload and privacy concern to health information avoidance behavior, respectively; and self-efficacy mediated the path from social support to health information avoidance behavior.Sociodemographic factors influencing cancer patients' health information avoidance behaviors include per capita monthly household income, occupation, treatment modality, number of years of smart device use, and number of hours per week reading health information. Self-efficacy and negative emotions mediated the analytic model of health information avoidance behavior in cancer patients, respectively.",
"Predictions": [
"Cancer"
],
@@ -440,13 +526,18 @@
"Aged",
"Socioeconomic Factors",
"Avoidance Learning"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736556",
"Title": "BMC public health",
"ArticleTitle": "Information needs for cancer screening and associated factors of information-seeking behaviour: a qualitative systematic review.",
- "Abstract": "The list of information needs identified in this review can serve as a reference for health professionals and information service providers before carrying out screening-related work to help the cancer screening participants obtain valuable information.",
+ "Abstract": "At present, the participation rate in cancer screening is still not ideal, and the lack of screening information or misunderstanding of information is an important factor hindering cancer screening behaviour. Therefore, a systematic synthesis of information needs related to cancer screening is critical.On July 23, 2024, we searched the Cochrane Library, MEDLINE (Ovid), Embase, EBSCO, PsycINFO, Scopus, ProQuest, PubMed, Web of Science, and CINAHL to collect qualitative or mixed-methods studies on information needs of cancer screening. We also searched for grey literature on OpenGrey and Google websites. Data were synthesised using Sandelowski and Barroso's framework. A top-down approach was adopted to group and synthesise the encodes and then generate analytical themes.A total of 37 studies were included. The results of the analysis of cancer screening-related information needs content, cancer-specific information needs content, requirements and preferences for information, and associated factors of information-seeking behaviour were reported. Based on the event timeline, we summarised the information needs of the screening demand side into four themes. Their information needs focus on disease risk factors, signs and symptoms, the importance of screening, the benefits and harms of screening, the detailed screening process, and screening results and explanations. Regarding cancer-specific information needs content, we summarised the specific information needs of cervical, breast, colorectal, and lung cancer. By referring to relevant concepts in the Comprehensive Model of Information Seeking, we synthesised the requirements and preferences for information according to the themes of editorial tone, communication potential, recommended information channels, and recommended source place. The information-seeking behaviours of the screening demanders are mainly passive attention and active searching. The common factors leading to the passive attention of screening demanders are demographic factors and fear of cancer. The most common reason for them to actively search information is lack of information.The list of information needs identified in this review can serve as a reference for health professionals and information service providers before carrying out screening-related work to help the cancer screening participants obtain valuable information.",
"Predictions": [
"Cancer"
],
@@ -457,13 +548,18 @@
"Qualitative Research",
"Neoplasms",
"Needs Assessment"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736554",
"Title": "BMC public health",
"ArticleTitle": "Pediatric and adolescent cancer disparities in the Middle East and North Africa (MENA) region: incidence, mortality, and survival across socioeconomic strata.",
- "Abstract": "These findings highlight the need for evidence-based interventions to reduce cancer-related mortality and disease burden among children and adolescents, particularly in low-income countries within the region and for cancer types with the highest mortality rates. Additionally, efforts should focus on establishing registries to provide up-to-date national data on cancer incidence and mortality in countries within the region.",
+ "Abstract": "Cancer is one of the leading causes of death in children and adolescents, with a significant concentration in low and middle-income countries. Previous research has identified disparities in cancer incidence and mortality based on a country's level of development. The Middle East and North Africa (MENA) region comprises of countries with heterogeneous income and development levels. This study aims to investigate whether discrepancies in cancer incidence and mortality among children and adolescents exist in countries within the MENA region.Data on cancer incidence and mortality were drawn from the Global Burden of Disease Study (GBD) 2019 for all malignant neoplasms (including non-melanoma skin cancers). The analysis was restricted to children and adolescents aged less than 20 years. Mortality- to-Incidence ratios (MIR) were calculated as a proxy measure of survival for each cancer type and country and Spearman's correlation coefficient measured the association between socio-demographic index (SDI), incidence rates, mortality rates, and MIR.In 2019, cancer incidence in the MENA region was 4.82/100,000 population, while mortality rate was 11.65/100,000 population. Cancer incidence and mortality was higher among males compared to females. A marked difference was observed in cancer-related mortality rates between low-income and high-income countries. MIR was higher in low-income countries, particularly for males and specific cancer types such as liver, colon and rectum, brain and central nervous system (CNS) cancers, and non-Hodgkin lymphoma among others. A negative correlation was observed between a country's SDI and MIR (-0.797) and SDI and mortality rates (-0.547) indicating that higher SDI corresponds to lower MIR and lower mortality rates.These findings highlight the need for evidence-based interventions to reduce cancer-related mortality and disease burden among children and adolescents, particularly in low-income countries within the region and for cancer types with the highest mortality rates. Additionally, efforts should focus on establishing registries to provide up-to-date national data on cancer incidence and mortality in countries within the region.",
"Predictions": [
"Cancer"
],
@@ -483,7 +579,12 @@
"Socioeconomic Factors",
"Young Adult",
"Infant, Newborn"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736368",
@@ -501,7 +602,12 @@
"Reactive Oxygen Species",
"Neoplasms",
"Lipid Peroxidation"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736217",
@@ -520,7 +626,12 @@
"Neoplasms",
"Biological Therapy",
"Biocompatible Materials"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736186",
@@ -538,1602 +649,1732 @@
"Neoplasms",
"Animals",
"Polysaccharides"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
- "PMID": "39736017",
- "Title": "Frontiers in bioscience (Scholar edition)",
- "ArticleTitle": "Evaluation of Reference Gene Stability for Investigations of Intracellular Signalling in Human Cancer and Non-Malignant Mesenchymal Stromal Cells.",
- "Abstract": "We analysed and selected stable reference genes for RT-qPCR analysis in the wide panel of cancer cell lines and MSCs. The study provides a reliable tool for future research concerning the expression of genes involved in various intracellular signalling pathways and emphasises the need for careful selection of suitable references before analysing target gene expression.",
+ "PMID": "39734005",
+ "Title": "Vascular pharmacology",
+ "ArticleTitle": "Interplay between CD28 and PD-1 in T cell immunotherapy.",
+ "Abstract": "Immune checkpoint therapy targeting the PD-1/PD-L1 axis has revolutionised the treatment of solid tumors. However, T cell exhaustion underpins resistance to current anti-PD-1 therapies, resulting in lower response rates in cancer patients. CD28 is a T cell costimulatory receptor that can influence the PD-1 signalling pathway (and vice versa). CD28 signalling has the potential to counter T cell exhaustion by serving as a potential complementary response to traditional anti-PD-1 therapies. Here we discuss the interplay between PD-1 and CD28 in T cell immunotherapy and additionally how CD28 transcriptionally modulates T cell exhaustion. We also consider clinical attempts at targeting CD28; the challenges faced by past attempts and recent promising developments.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Mesenchymal Stem Cells",
- "Neoplasms",
- "Gene Expression",
"Humans",
- "HeLa Cells",
- "MCF-7 Cells",
- "A549 Cells",
- "Reference Values",
- "Genes, Essential",
- "Real-Time Polymerase Chain Reaction"
- ]
+ "CD28 Antigens",
+ "Programmed Cell Death 1 Receptor",
+ "Immune Checkpoint Inhibitors",
+ "Animals",
+ "Signal Transduction",
+ "T-Lymphocytes",
+ "Neoplasms",
+ "Immunotherapy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
- "PMID": "39735992",
- "Title": "Frontiers in bioscience (Landmark edition)",
- "ArticleTitle": "Gene Fusion Detection in Long-Read Transcriptome Datasets from Multiple Cancer Cell Lines.",
- "Abstract": "The application of our tool to the detection of fusion genes in long-read RNA-seq datasets from two different cancer cell lines demonstrated the detection effectiveness of this tool.",
+ "PMID": "39732595",
+ "Title": "Trends in cancer",
+ "ArticleTitle": "KRAS inhibitors: resistance drivers and combinatorial strategies.",
+ "Abstract": "In 1982, the RAS genes HRAS and KRAS were discovered as the first human cancer genes, with KRAS later identified as one of the most frequently mutated oncogenes. Yet, it took nearly 40 years to develop clinically effective inhibitors for RAS-mutant cancers. The discovery in 2013 by Shokat and colleagues of a druggable pocket in KRAS paved the way to FDA approval of the first covalently binding KRAS inhibitors, sotorasib and adagrasib, in 2021 and 2022, respectively. However, rather than marking the end of a successful assault on the Mount Everest of cancer research, this landmark only revealed new challenges in RAS drug discovery. In this review, we highlight the progress on defining resistance mechanisms and developing combination treatment strategies to improve patient responses to KRAS therapies.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Cell Line, Tumor",
- "Transcriptome",
+ "Proto-Oncogene Proteins p21(ras)",
+ "Drug Resistance, Neoplasm",
"Neoplasms",
- "Gene Fusion",
- "Sequence Analysis, RNA",
- "Gene Expression Profiling",
- "Oncogene Proteins, Fusion"
- ]
+ "Mutation",
+ "Antineoplastic Combined Chemotherapy Protocols",
+ "Molecular Targeted Therapy",
+ "Antineoplastic Agents",
+ "Piperazines",
+ "Pyridines",
+ "Pyrimidines"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39735988",
- "Title": "Frontiers in bioscience (Landmark edition)",
- "ArticleTitle": "The Warburg Effect: Is it Always an Enemy?",
- "Abstract": "The Warburg effect, also known as 'aerobic' glycolysis, describes the preference of cancer cells to favor glycolysis over oxidative phosphorylation for energy (adenosine triphosphate-ATP) production, despite having high amounts of oxygen and fully active mitochondria, a phenomenon first identified by Otto Warburg. This metabolic pathway is traditionally viewed as a hallmark of cancer, supporting rapid growth and proliferation by supplying energy and biosynthetic precursors. However, emerging research indicates that the Warburg effect is not just a strategy for cancer cells to proliferate at higher rates compared to normal cells; thus, it should not be considered an 'enemy' since it also plays complex roles in normal cellular functions and/or under stress conditions, prompting a reconsideration of its purely detrimental characterization. Moreover, this review highlights that distinguishing glycolysis as 'aerobic' and 'anaerobic' should not exist, as lactate is likely the final product of glycolysis, regardless of the presence of oxygen. Finally, this review explores the nuanced contributions of the Warburg effect beyond oncology, including its regulatory roles in various cellular environments and the potential effects on systemic physiological processes. By expanding our understanding of these mechanisms, we can uncover novel therapeutic strategies that target metabolic reprogramming, offering new avenues for treating cancer and other diseases characterized by metabolic dysregulation. This comprehensive reevaluation not only challenges traditional views but also enhances our understanding of cellular metabolism's adaptability and its implications in health and disease.",
+ "PMID": "39731788",
+ "Title": "European journal of medicinal chemistry",
+ "ArticleTitle": "Recent progress in the development of peptide-drug conjugates (PDCs) for cancer therapy.",
+ "Abstract": "Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides, linkers, and payloads, which possess favorable targeting capability and can deliver enough payloads to the tumor sites with minimized impact on healthy tissues. However, only a few PDCs have been approved for clinical use so far. To advance the research on PDCs, this review summarizes the approved PDCs, and PDCs in clinical and preclinical stages based on the payload types. Additionally, the biological activity and pharmacokinetic properties of preclinical PDCs are detailedly described. Lastly, the challenges and future development directions of PDCs are discussed. This review aims to inspire insights into the development of PDCs for cancer treatment.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Warburg Effect, Oncologic",
"Neoplasms",
- "Glycolysis",
+ "Antineoplastic Agents",
+ "Peptides",
"Animals",
- "Oxidative Phosphorylation",
- "Energy Metabolism",
- "Mitochondria",
- "Cell Proliferation"
- ]
+ "Drug Development",
+ "Molecular Structure"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39735979",
- "Title": "Frontiers in bioscience (Landmark edition)",
- "ArticleTitle": "Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.",
- "Abstract": [
- "Functional clustering results showed that aneuploidy and stemness were significantly associated in kidney chromophobe (KICH) and thyroid carcinoma (THCA). And cell metabolism and cell cycle had key effects. Residual analysis indicates superior screening performance by random forest (RF). An aneuploid feature gene set with ",
- {
- "i": "MARCKS"
- }
- ],
+ "PMID": "39722418",
+ "Title": "Biochimica et biophysica acta. Reviews on cancer",
+ "ArticleTitle": "Emerging role of EZH2 in solid tumor metastasis.",
+ "Abstract": "Cancer cells experience multiple reversible changes during their metastatic spread. Epigenetic reprogramming, being reversible, has emerged as a critical driver of cancer metastasis. Epigenetic modulator Enhancer of Zeste homolog 2 (EZH2) is an important candidate for such reprogramming events. Both EZH2 protein and its catalytic function (H3K27me3) have been shown to promote solid tumor metastasis, although EZH2 functional inhibition has limited impact on primary tumor growth in some cancers. The dichotomous gene regulatory roles of EZH2 and H3K27me3 are currently being investigated to understand how they collectively contribute to promote metastasis. Here, we examine the multifaceted role of EZH2 in modulating solid tumor metastasis and its therapeutic potential.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Enhancer of Zeste Homolog 2 Protein",
"Humans",
- "Aneuploidy",
- "Machine Learning",
"Neoplasms",
- "Myristoylated Alanine-Rich C Kinase Substrate",
- "Membrane Proteins",
+ "Neoplasm Metastasis",
+ "Epigenesis, Genetic",
"Gene Expression Regulation, Neoplastic",
- "Cell Proliferation",
- "Cytoskeletal Proteins"
- ]
+ "Animals",
+ "Histones"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39735978",
- "Title": "Frontiers in bioscience (Landmark edition)",
- "ArticleTitle": "The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype.",
- "Abstract": "Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within the local environment, TAMs may promote tumor angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit tumor progression via neoantigen presentation, tumoricidal reactive oxygen species generation and pro-inflammatory cytokine secretion. Therefore, TAMs have a pivotal role in determining tumor progression and response to therapy. TAM phenotypes are driven by cytokines and physical cues produced by tumor cells, adipocytes, fibroblasts, pericytes, immune cells, and other cells within the TME. Research has shown that TAMs can be primed by environmental stimuli, adding another layer of complexity to the environmental context that determines TAM phenotype. Innate priming is a functional consequence of metabolic and epigenetic reprogramming of innate cells by a primary stimulant, resulting in altered cellular response to future secondary stimulation. Innate priming offers a novel target for development of cancer immunotherapy and improved prognosis of disease, but also raises the risk of exacerbating existing inflammatory pathologies. This review will discuss the mechanisms underlying innate priming including metabolic and epigenetic modification, its relevance to TAMs and tumor progression, and possible clinical implications for cancer treatment.",
+ "PMID": "39721924",
+ "Title": "Trends in cell biology",
+ "ArticleTitle": "Targeting the ubiquitin proteasome system in cancer stem cells.",
+ "Abstract": "Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype. This forum article aims to outline new strategies/technologies targeting UPS modulation in CSCs as a potential novel modality for efficient cancer therapy.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Immunity, Innate",
- "Tumor-Associated Macrophages",
+ "Neoplastic Stem Cells",
+ "Proteasome Endopeptidase Complex",
+ "Ubiquitin",
"Neoplasms",
- "Tumor Microenvironment",
- "Phenotype",
- "Animals",
- "Epigenesis, Genetic"
- ]
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39735682",
- "Title": "Oncology research",
- "ArticleTitle": "HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation.",
- "Abstract": "In summary, our findings highlight HNRNPC as a prognostic marker in various cancers, including liver cancer, and suggest its involvement in shaping the tumor immune microenvironment. These insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression, particularly through immunotherapeutic strategies.",
+ "PMID": "39721827",
+ "Title": "Trends in pharmacological sciences",
+ "ArticleTitle": "A novel pharmacological entity toward integrated multimodal immunotherapy.",
+ "Abstract": "Most solid tumors are insensitive to single-agent immunotherapy, calling for the development of combinatorial treatment regimens. Recently, Lin and collaborators developed a pharmacological platform enabling the combination of different immunotherapies into a single chemical entity. This approach may effectively circumvent obstacles associated with the simultaneous delivery of multiple immunotherapeutic agents.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Biomarkers, Tumor",
- "Disease Progression",
- "Heterogeneous-Nuclear Ribonucleoprotein Group C",
+ "Immunotherapy",
"Neoplasms",
- "Tumor Microenvironment",
- "Prognosis",
- "Gene Expression Regulation, Neoplastic",
- "Liver Neoplasms",
- "Cell Line, Tumor",
- "Cell Proliferation"
- ]
+ "Combined Modality Therapy",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39735681",
- "Title": "Oncology research",
- "ArticleTitle": "Research advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells.",
- "Abstract": "Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between ligands and receptors have shown promise in selectively targeting and destroying cancer cells. This review aims to provide a comprehensive overview of various nanoparticle and cell-based drug delivery system types used in cancer research. It covers approved and experimental nanoparticle therapies, including liposomes, micelles, protein-based and polymeric nanoparticles, as well as cell-based DDSs like macrophages, T-lymphocytes, dendritic cells, viruses, bacterial ghosts, minicells, SimCells, and outer membrane vesicles (OMVs). The review also explains the role of TME and its impact on developing smart DDSs in combination therapies and integrating nanoparticles with cell-based systems for targeting cancer cells. By detailing DDSs at different stages of development, from laboratory research to clinical trials and approved treatments, this review provides the latest insights and a collection of valuable citations of the innovative strategies that can be improved for the precise treatment of cancer.",
+ "PMID": "39721773",
+ "Title": "Gan to kagaku ryoho. Cancer & chemotherapy",
+ "ArticleTitle": "[Human Resources Development in Cancer Research].",
+ "Abstract": "There exist many issues concerning human resources development in cancer research. Not a single solution does not work, but correlative issues should be continuously and comprehensively considered. Board certification platform, timing of decisions to go to graduate school of medicine and to study abroad for young researchers: leading to the education for physician scientists, grants(Kakenhi)reduction, the Work System Reform for medical doctors, promotion women researchers for managerial posts, etc. Every researcher can network interdisciplinary and expand the possibility of the carrier to solve unanswered social issues.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Humans",
"Neoplasms",
- "Nanoparticles",
- "Drug Delivery Systems",
- "Tumor Microenvironment",
- "Antineoplastic Agents",
- "Animals"
- ]
+ "Humans",
+ "Biomedical Research"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39735536",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors.",
- "Abstract": "Our data highlighted that NECTIN-4 TAC28-T cells may represent a promising, safe and effective cell therapy for NECTIN-4-overexpressing solid tumors.",
+ "PMID": "39721322",
+ "Title": "Current opinion in genetics & development",
+ "ArticleTitle": "Decoding cancer etiology with cellular reprogramming.",
+ "Abstract": "Cancer research remains clinically unmet in many areas due to limited access to patient samples and the lack of reliable model systems that truly reflect human cancer biology. The emergence of patient-derived induced pluripotent stem cells and engineered human pluripotent stem cells (hPSCs) has helped overcome these challenges, offering a versatile alternative platform for advancing cancer research. These hPSCs are already proving to be valuable models for studying specific cancer driver mutations, offering insights into cancer origins, pathogenesis, tumor heterogeneity, clonal evolution, and facilitating drug discovery and testing. This article reviews recent progress in utilizing hPSCs for clinically relevant cancer models and highlights efforts to deepen our understanding of fundamental cancer biology.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Animals",
"Humans",
- "CD28 Antigens",
- "Mice",
- "Cell Adhesion Molecules",
+ "Cellular Reprogramming",
"Neoplasms",
- "Lymphocyte Activation",
- "Cell Line, Tumor",
- "Immunotherapy, Adoptive",
- "T-Lymphocytes",
- "Receptors, Antigen, T-Cell",
- "Xenograft Model Antitumor Assays",
- "Female",
- "Nectins"
- ]
+ "Induced Pluripotent Stem Cells",
+ "Mutation",
+ "Pluripotent Stem Cells",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39735534",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Abscopal effect of focused ultrasound combined immunotherapy in animal solid tumor model: a systematic reviews and meta-analysis.",
- "Abstract": "https://www.crd.york.ac.uk/prospero/, identifier CRD42023460710.",
+ "PMID": "39720929",
+ "Title": "Journal of medicinal chemistry",
+ "ArticleTitle": "Theranostic Rhenium(I)-Based ER-Phagy Retardant Promotes Immunogenic Cell Death.",
+ "Abstract": "ER-phagy is a double-edged sword in the occurrence, development, and treatment of cancer; especially, its functions in immunotherapy are still unknown. In this work, we designed a theranostic Re complex () containing a BODIPY-derived ligand and a \u03b2-carboline ligand to target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. Interestingly, as validated both in vitro and in vivo, ER-phagy blockage greatly enhances the capability of to induce immunogenic cell death (ICD). In summary, we dexterously fused two molecular modules for ER targeting and ER-phagy blockage into a coordination complex to afford a highly effective ICD inducer, which provides clues for designing new cancer immunotherapeutics.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Immunogenic Cell Death",
+ "Humans",
+ "Rhenium",
"Animals",
- "Immunotherapy",
+ "Mice",
+ "Endoplasmic Reticulum",
+ "Coordination Complexes",
+ "Theranostic Nanomedicine",
+ "Boron Compounds",
+ "Cell Line, Tumor",
+ "Carbolines",
+ "Antineoplastic Agents",
"Neoplasms",
- "Combined Modality Therapy",
- "Humans",
- "Ultrasonic Therapy",
- "Disease Models, Animal"
- ]
+ "Female",
+ "Ligands"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
- "PMID": "39735533",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.",
- "Abstract": "Our study demonstrates the potential of urine-based metabolomics for multi-cancer early detection. The approach offers non-invasive cancer screening, promising widespread implementation in population-based programs for early detection and improved outcomes. Further validation and expansion are needed for broader clinical applicability.",
+ "PMID": "39719324",
+ "Title": "RNA (New York, N.Y.)",
+ "ArticleTitle": "-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity.",
+ "Abstract": "Recent studies have revealed that the YTHDF family proteins bind preferentially to the -methyladenosine (mA)-modified mRNA and regulate the functions of these RNAs in different cell types. YTHDF2, the first identified mA reader in mammals, has garnered significant attention because of its profound effect to regulate the mA epitranscriptome in multiple biological processes. Here, we review current knowledge on the mechanisms by which YTHDF2 exerts its functions and discuss recent advances that underscore the multifaceted role of YTHDF2 in development, stem cell expansion, and immune evasion. We also highlight potential therapeutic interventions targeting the mA/YTHDF2 axis to improve the response to current antitumor therapies.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Early Detection of Cancer",
- "Metabolomics",
- "Male",
- "Female",
- "Biomarkers, Tumor",
- "Middle Aged",
- "Aged",
- "Stomach Neoplasms",
- "Colorectal Neoplasms",
- "Metabolome",
- "Adult",
- "Lung Neoplasms",
- "Neoplasms"
- ]
+ "RNA-Binding Proteins",
+ "Adenosine",
+ "Animals",
+ "Neoplasms",
+ "RNA, Messenger"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
- "PMID": "39734197",
- "Title": "Epigenetics & chromatin",
- "ArticleTitle": "Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology.",
- "Abstract": "DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated. Nanopore sequencing has emerged as a novel technique that can analyze long strands of DNA (long-read sequencing) without chemically treating the DNA. Interestingly, nanopore sequencing can also extract epigenetic status of the nucleotides (including both 5-Methylcytosine and 5-hydroxyMethylcytosine), and a large variety of bioinformatic tools have been developed for improving its detection properties. Out of all genomic regions, long read sequencing provides advantages in studying repetitive elements, which are difficult to characterize through other sequencing methods. Transposable elements are repetitive regions of the genome that are silenced and usually display high levels of DNA methylation. Their demethylation and activation have been observed in many cancers. Due to their repetitive nature, it is challenging to accurately estimate DNA methylation levels within transposable elements using short sequencing technologies. The advantage to sequence native DNA (without PCR amplification biases or harsh bisulfite treatment) and long and ultra long reads coupled with epigenetic states of the DNA allows to accurately estimate DNA methylation levels in transposable elements. This is a big step forward for epigenomic studies, and unsolved questions regarding gene expression and transposable elements silencing through DNA methylation can now be answered.",
+ "PMID": "39711461",
+ "Title": "Future oncology (London, England)",
+ "ArticleTitle": "Tumor mutational burden: why is it still a controversial agnostic immunotherapy biomarker?",
+ "Abstract": "For the past few years, researchers and oncologists have been pushing to find biomarkers that would help predict which treatment option would best work on a patient. Tumor Mutational Burden (TMB) is one of the latest biomarkers that is being studied and considered as a promising agnostic immunotherapy biomarker. However, it still shows controversial results in studies due to the difficulty in finding solid comparable results. This is a consequence of different cutoff definitions among many cancer types, age ranges, and the use of different sequencing assays, in addition to its association with other biomarkers such as PD-L1. Finally, the use of composite biomarkers to assess the genetic signature of a tumor might be the way forward to seriously use TMB as an agnostic biomarker.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Animals",
"Humans",
- "5-Methylcytosine",
- "DNA Methylation",
- "DNA Transposable Elements",
- "Epigenesis, Genetic",
- "Nanopore Sequencing",
- "Nanopores",
+ "Biomarkers, Tumor",
"Neoplasms",
- "Sequence Analysis, DNA"
- ]
+ "Mutation",
+ "Immunotherapy",
+ "B7-H1 Antigen",
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39733511",
- "Title": "Bioorganic chemistry",
- "ArticleTitle": "Protein arginine methyltransferase 7 modulators in disease therapy: Current progress and emerged opportunity.",
- "Abstract": "Protein arginine methyltransferase 7 (PRMT7) is an essential epigenetic and post-translational regulator in eukaryotic organisms. Dysregulation of PRMT7 is intimately related to multiple types of human diseases, particularly cancer. In addition, PRMT7 exerts multiple effects on cellular processes such as growth, migration, invasion, apoptosis, and drug resistance in various cancers, making it as a promising target for anti-tumor therapeutics. In this review, we initially provide an overview of the structure and biological functions of PRMT7, along with its association with diseases. Subsequently, we summarized the PRMT inhibitors in clinical trials and the co-crystal structural of PRMT7 inhibitors. Moreover, we also focus on recent progress in the design and development of modulators targeting PRMT7, including isoform-selective and non-selective PRMT7 inhibitors, and the dual-target inhibitors based on PRMT7, from the perspectives of rational design, pharmacodynamics, pharmacokinetics, and the clinical status of these modulators. Finally, we also provided the challenges and prospective directions for PRMT7 targeting drug discovery in cancer therapy.",
+ "PMID": "39711326",
+ "Title": "Chemical communications (Cambridge, England)",
+ "ArticleTitle": "Design of an anti-PD-L1-mediated MOF nanodrug delivery system using terpyridine-metal coordination for tumor theranostics.",
+ "Abstract": "An anti-PD-L1 mediated nanodrug delivery system is developed by modifying the MOF surface and using Tpy-Gd-Tpy coordination chemistry, enabling the simultaneous delivery of chemotherapy and immunotherapy drugs. The platform enables regulated drug release and integrates multiple imaging modalities, promoting targeted delivery and facilitating tumor diagnosis through FL and MR imaging.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Protein-Arginine N-Methyltransferases",
"Humans",
- "Enzyme Inhibitors",
- "Neoplasms",
+ "Metal-Organic Frameworks",
+ "B7-H1 Antigen",
+ "Pyridines",
"Antineoplastic Agents",
- "Molecular Structure",
- "Animals"
- ]
+ "Theranostic Nanomedicine",
+ "Drug Delivery Systems",
+ "Neoplasms",
+ "Animals",
+ "Mice",
+ "Coordination Complexes",
+ "Drug Liberation",
+ "Drug Carriers",
+ "Gadolinium",
+ "Cell Line, Tumor"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39733440",
- "Title": "Asian Pacific journal of cancer prevention : APJCP",
- "ArticleTitle": "Update on Occupational Cancer for Better Cancer Prevention and Control.",
- "Abstract": "Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations between occupational carcinogens and cancer. Diagnosing occupational cancer and investigating clusters are crucial for understanding its etiology. Prevention at every level- from primary to quarterly prevention- and promotional activities are crucial for exposed workers, often outweighing the importance of treatment, which can be costly. This updated information, as reviewed in this article, and cooperative work with occupational medicine physicians, could contribute to improving clinical practices for better cancer prevention and control.",
+ "PMID": "39710702",
+ "Title": "Journal of translational medicine",
+ "ArticleTitle": "Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer.",
+ "Abstract": "The identification of ferroptosis represents a pivotal advancement in the field of cell death research, revealing an entirely novel mechanism of cellular demise and offering new insights into the initiation, progression, and therapeutic management of various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments in the antioxidant defense system, culminating in membrane rupture and consequent cell death. Studies have associated ferroptosis with a wide range of diseases, and by enhancing our comprehension of its underlying mechanisms, we can formulate innovative therapeutic strategies, thereby providing renewed hope for patients.",
"Predictions": [
- "Cancer"
+ "Cancer",
+ "Cardiovascular diseases"
],
"MeshTerms": [
+ "Ferroptosis",
"Humans",
+ "Neurodegenerative Diseases",
+ "Cardiovascular Diseases",
"Neoplasms",
- "Occupational Exposure",
- "Occupational Diseases",
- "Carcinogens"
- ]
+ "Animals",
+ "Molecular Targeted Therapy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39733439",
- "Title": "Asian Pacific journal of cancer prevention : APJCP",
- "ArticleTitle": "Deciphering Antigen Processing Machinery (APM) as One of the Determinants for Responsiveness of Affected Patients towards Anticancer Immunotherapy.",
- "Abstract": "Immunotherapy is one of the rising stars in the field of anticancer regiments. Aimed at reinvigorating immune cytotoxicity, this platform is capable of bulking up memory subsets by which protection against tumors is served. The most commonly applied immunotherapy is immune checkpoint inhibitor (ICIs) which received FDA approval for non-small lung cancer (NSLC) in 2014. The response toward ICI is closely related to the antigen processing machinery (APM) within which antigens are processed prior to loading onto the human leukocyte antigen (HLA) to induce cascade mechanisms for immune clearance. APM allows immune cell infiltration thus strengthens immunogenicity. Impaired components of the APM are frequently found in tumors because tumor progression requires tumor cells to acquire immune recognition evasion. Alterations in tumors' APM result in downregulation of HLA molecules and transformation of antigenic peptide repertoire presented to the T lymphocytes. Interactions of processed antigens (peptide)-HLA complex are critical for successful T cell priming and differentiation into cytotoxic effector cells. The interaction underlies not only ICI-related mechanism but also anticancer immunity in general where T cell subset can induce antitumor recognition only if a proper peptide-HLA complex is present. This feature, unfortunately, is missing in tumors. This Review highlights presentation of tumor-specific antigens to T cells in HLA-restricted manner which leads to their eradication. This is a pivotal point but in most cases is overlooked which might add some volume to the off-target and less functional of anticancer immunotherapy.",
+ "PMID": "39710233",
+ "Title": "Drug discovery today",
+ "ArticleTitle": "Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects.",
+ "Abstract": "Salt-inducible kinases (SIKs), a group of serine/threonine kinases in the adenosine monophosphate-activated protein kinase (AMPK) family, exist in three isoforms: SIK1, SIK2 and SIK3. These kinases are crucial in various physiological processes. Emerging evidence indicates that dysregulation of SIK expression and activation significantly contributes to carcinogenesis by promoting cellular proliferation, metabolic dysregulation, metastasis and chemoresistance through the modulation of crucial signaling pathways. The role of SIKs in cancer progression and metastasis involves complex mechanisms that vary among cancer types. Additionally, research on SIK inhibitors suggests that targeting these kinases might offer promising avenues for improving cancer treatment outcomes.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Antigen Presentation",
- "Immunotherapy",
"Neoplasms",
- "Antigens, Neoplasm",
- "Immune Checkpoint Inhibitors",
- "HLA Antigens"
- ]
+ "Protein Serine-Threonine Kinases",
+ "Animals",
+ "Antineoplastic Agents",
+ "Signal Transduction",
+ "Protein Kinase Inhibitors",
+ "Molecular Targeted Therapy",
+ "Cell Proliferation",
+ "Protein Kinases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39733429",
- "Title": "Asian Pacific journal of cancer prevention : APJCP",
- "ArticleTitle": "Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry.",
- "Abstract": "Cancer incidence level in Northern Tunisia place the country in an intermediate level and projections seem to be worrying. Strengthening prevention, screening and early diagnosis are strongly recommended.",
+ "PMID": "39709166",
+ "Title": "Life sciences",
+ "ArticleTitle": "The many faces of DGAT1.",
+ "Abstract": "Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a multifaced enzyme with a wide spectrum of substrates, from lipids through waxes to retinoids, which makes it an interesting therapeutic target. DGAT1 inhibitors are currently at various stages of preclinical and clinical trials, mostly related to metabolic diseases. Interestingly, in recent years, a growing amount of research has shown the influence of DGAT1 on immune cell metabolism and functions, highlighting its important role during infections and tumorigenesis. In this review, we aim to elucidate the potential immunomodulatory effect of DGAT1 in physiological and pathological conditions.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Diacylglycerol O-Acyltransferase",
"Humans",
- "Registries",
- "Female",
- "Male",
- "Tunisia",
+ "Animals",
"Neoplasms",
- "Incidence",
- "Middle Aged",
- "Adult",
- "Aged",
- "Adolescent",
- "Young Adult",
- "Infant, Newborn",
- "Infant",
- "Child",
- "Child, Preschool",
- "Follow-Up Studies",
- "Prognosis",
- "Aged, 80 and over"
- ]
+ "Metabolic Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39733076",
- "Title": "Scientific reports",
- "ArticleTitle": "Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome.",
- "Abstract": "Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles in cancer progression and therapy resistance. Despite this, the functional diversity of mitochondria across various cancer types remains inadequately characterized. This study seeks to fill this knowledge gap by introducing and validating MitoScore-a novel metric designed to quantitatively assess mitochondrial function across a wide array of cancers. Our investigation evaluates the capacity of MitoScore not only to distinguish between tumor and adjacent normal tissues but also to serve as a predictive marker for clinical outcomes. We analyzed gene expression data from 24 cancer types and corresponding normal tissues using the TCGA database. MitoScore was calculated by summing the normalized expression levels of six mitochondrial genes known to be consistently altered across multiple cancers. Differential gene expression was assessed using DESeq2, with a focus on identifying significant changes in mitochondrial function. MitoScore's associations with tumor proliferation, hypoxia, aneuploidy, and clinical outcomes were evaluated using Spearman's correlation, linear regression, and Kaplan-Meier survival analyses. MitoScore was significantly higher in tumor tissues compared to normal tissues across most cancer types (p\u2009<\u20090.001). It positively correlated with tumor proliferation rates (r\u2009=\u20090.46), hypoxia scores (r\u2009=\u20090.61), and aneuploidy (r\u2009=\u20090.44), indicating its potential as a marker of aggressive tumor behavior. High MitoScore was also associated with poorer prognosis in several cancer types, suggesting its utility as a predictive biomarker for clinical outcomes. This study introduces MitoScore, a metric for mitochondrial activity often elevated in tumors and linked to poor prognosis. It correlates positively with hypoxia and negatively with stromal and immune infiltration, highlighting mitochondria's role in the tumor microenvironment. MitoScore's association with genomic instability, such as aneuploidy, suggests mitochondrial dysfunction contributes to cancer progression. Despite challenges in mitochondrial-targeted therapies, MitoScore may identify tumors responsive to such treatments, warranting further research for clinical application.",
+ "PMID": "39709065",
+ "Title": "Molecular and cellular probes",
+ "ArticleTitle": "The application of CRISPR/Cas9-based genome-wide screening to disease research.",
+ "Abstract": "High-throughput genetic screening serves as an indispensable approach for deciphering gene functions and the intricate relationships between phenotypes and genotypes. The CRISPR/Cas9 system, with its ability to precisely edit genomes on a large scale, has revolutionized the field by enabling the construction of comprehensive genomic libraries. This technology has become a cornerstone for genome-wide screenings in disease research. This review offers a comprehensive examination of how CRISPR/Cas9-based genetic screening has been leveraged to uncover genes that play a role in disease mechanisms, focusing on areas such as cancer development and viral replication processes. The insights presented in this review hold promise for the development of novel therapeutic strategies and precision medicine approaches.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "CRISPR-Cas Systems",
"Humans",
- "Neoplasms",
- "Mitochondria",
- "Gene Expression Regulation, Neoplastic",
- "Biomarkers, Tumor",
- "Prognosis",
- "Genomics",
- "Cell Proliferation",
- "Kaplan-Meier Estimate"
- ]
+ "Genome-Wide Association Study",
+ "Genetic Testing",
+ "Animals",
+ "Gene Editing",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39732961",
- "Title": "Scientific reports",
- "ArticleTitle": "Pan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers.",
- "Abstract": "Polyomavirus enhancer activator 3 (PEA3), an ETS transcription factor, has been documented to regulate the development and metastasis of human cancers. Nonetheless, a thorough analysis examining the relationship between the PEA3 subfamily members and tumour development, prognosis, and the tumour microenvironment (TME) across various cancer types has not yet been conducted. The expression profiles and prognostic significance of the PEA3 subfamily were evaluated using data from the GEO, TCGA, and PrognoScan databases, in conjunction with COX regression analyses and the Kaplan-Meier Plotter. Furthermore, the relationships between PEA3 subfamily expression, stemness scores, tumor microenvironments, immune subtypes, and drug susceptibility across multiple cancer types were explored. We found that ETV1, ETV4 and ETV5 are highly expressed in cancer, and their biological functions are synergistic. In the prognostic analysis of the Cancer Genome Atlas, the PEA3 subfamily genes were found to be associated with the prognosis of multiple cancers such as Lung adenocarcinoma (LUAD), Liver hepatocellular carcinoma (LIHC), etc., and marked a worse prognosis at different endpoints. In addition, it was significantly correlated with the stromal and immune scores of pan-cancer, and also significantly associated with the RNA stemness score and DNA stemness score of pan-cancer. Expression levels of the PEA3 subfamily genes correlate with immune subtypes of LIHC, LUAD, and Lung squamous cell carcinoma. We also found a variety of drugs with positive and negative associations of ETV1, ETV4 and ETV5. These findings elucidate the role of the PEA3 subfamily gene as a biomarker for carcinogenesis and cancer progression, offering valuable insights for future research into the PEA3 subfamily gene as a potential therapeutic target across various cancer types.",
+ "PMID": "39708912",
+ "Title": "Journal of molecular biology",
+ "ArticleTitle": "Structural Dynamics of Rho GTPases.",
+ "Abstract": "Rho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations have only been discovered in the last decade. Like that of Ras, an in-depth understanding of the structural basis of how Rho GTPases and their mutants behave as key oncogenic drivers benefits the development of clinically effective therapies. Recent studies of structure dynamics in Rho GTPase structure-function relationship have added new twists to the conventional wisdom of Rho GTPase signaling mechanism.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "rho GTP-Binding Proteins",
"Humans",
- "Biomarkers, Tumor",
- "Transcription Factors",
- "Proto-Oncogene Proteins c-ets",
- "Prognosis",
- "Neoplasms",
- "Gene Expression Regulation, Neoplastic",
- "Tumor Microenvironment",
- "Adenovirus E1A Proteins",
- "DNA-Binding Proteins",
- "Kaplan-Meier Estimate",
- "Gene Expression Profiling"
- ]
+ "Signal Transduction",
+ "Protein Conformation",
+ "Structure-Activity Relationship",
+ "Mutation",
+ "Models, Molecular",
+ "Animals",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39732661",
- "Title": "BMC infectious diseases",
- "ArticleTitle": "Onco-mNGS facilitates rapid and precise identification of the etiology of fever of unknown origin: a single-centre prospective study in North China.",
- "Abstract": "Onco-mNGS is an ideal rapid diagnostic aid to assist improving the early diagnostic efficiency of FUO-associated diseases.",
+ "PMID": "39708554",
+ "Title": "Bioorganic chemistry",
+ "ArticleTitle": "Targeting XPO1 for fighting relapsed/refractory diseases: The research progress of XPO1 inhibitors.",
+ "Abstract": "XPO1 is an influential member of the nuclear transporter protein family. The proteins and RNA transported by XPO1 are related to the occurrence and development of many diseases, including refractory tumor diseases and various viral infectious diseases. XPO1 is upregulated in many malignant tumors and is associated with poor prognosis. This article reviews the anti-tumor and anti-viral mechanisms of XPO1, and summarizes the biomarkers that predict the response to XPO1 inhibitors and the research progress of XPO1 as a biomarker in different diseases. In addition, we also summarize the research status of XPO1 inhibitors, and discuss the structure-activity relationship of preclinical inhibitors targeting XPO1 and the research status of XPO1 inhibitor resistance mechanisms.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Fever of Unknown Origin",
- "Prospective Studies",
- "Female",
- "Male",
- "China",
- "Middle Aged",
- "Adult",
- "Aged",
+ "Exportin 1 Protein",
+ "Receptors, Cytoplasmic and Nuclear",
+ "Karyopherins",
+ "Structure-Activity Relationship",
"Neoplasms",
- "Young Adult"
- ]
+ "Antineoplastic Agents",
+ "Molecular Structure",
+ "Animals",
+ "Antiviral Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39732529",
- "Title": "Trends in immunology",
- "ArticleTitle": "Targeting molecular pathways to control immune checkpoint inhibitor toxicities.",
- "Abstract": "Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It examines key immune cells, such as T cell subsets and myeloid cells, which are instrumental in irAE pathogenesis, alongside an in-depth analysis of cytokine signaling [interleukin (IL)-6, IL-17, IL-4), interferon \u03b3 (IFN-\u03b3), IL-1\u03b2, tumor necrosis factor \u03b1 (TNF-\u03b1)], integrin-mediated interactions [integrin subunits \u03b1ITGA)4 and ITGB7], and microbiome-related factors that contribute to irAE pathology. This exploration of modifiable pathways uncovers new opportunities to mitigate irAEs by using available antibodies (Abs) that target key inflammatory molecules across tumor types, while ideally preserving the antitumor efficacy of ICIs.",
+ "PMID": "39706502",
+ "Title": "Experimental gerontology",
+ "ArticleTitle": "Editorial for the special issue on \"microbiomes in extremes of aging\".",
+ "Abstract": "This special issue of the Journal of Experimental Gerontology explores the dynamic interplay between microbiomes and aging-related conditions. The four selected studies highlight the role of microbiota in Alzheimer's disease, cancer immunotherapy, myocardial infarction and tryptophan metabolism, providing insights into how microbiomes influence health and disease in aging. These studies underscore the potential for microbiome-targeted interventions to mitigate aging-related disorders and improve the quality of life for older adults.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Immune Checkpoint Inhibitors",
+ "Aging",
+ "Alzheimer Disease",
+ "Microbiota",
+ "Quality of Life",
+ "Myocardial Infarction",
+ "Gastrointestinal Microbiome",
"Neoplasms",
- "Animals",
- "Signal Transduction",
- "Cytokines",
"Immunotherapy",
- "Molecular Targeted Therapy"
- ]
+ "Tryptophan",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
- "PMID": "39732497",
- "Title": "BMJ open",
- "ArticleTitle": "Co-designing a low-intensity psychological therapy for fear of recurrence in psychosis using translational learning from fear of recurrence in oncology: protocol for intervention development for future testing in a feasibility study.",
- "Abstract": "The INDIGO study received ethical approval from East Midlands-Nottingham 2 Research Ethics Committee (24/EM/0124). The study received independent peer review prior to funding. This co-design study is expected to lead to a future feasibility study and, if indicated, a randomised controlled trial.",
+ "PMID": "39706167",
+ "Title": "Cell chemical biology",
+ "ArticleTitle": "Macrophages make \"sense\" of obesity-driven acidity in the TME.",
+ "Abstract": "Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et\u00a0al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth..",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Obesity",
"Humans",
- "Feasibility Studies",
- "Fear",
- "Schizophrenia",
- "Psychotic Disorders",
+ "Macrophages",
+ "Receptors, G-Protein-Coupled",
+ "Tumor Microenvironment",
+ "Hydrogen-Ion Concentration",
+ "Animals",
"Neoplasms",
- "Psychosocial Intervention",
- "Neoplasm Recurrence, Local",
- "Research Design"
- ]
+ "Tumor-Associated Macrophages"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
- "PMID": "39732363",
- "Title": "Life sciences",
- "ArticleTitle": "CAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach.",
- "Abstract": "Our approach contributes to a better understanding of immune cell migration and the influence of mechanical constraints, which will allow the testing of new ways to improve CAR-T cell trafficking into solid tumours. Therefore, our study revealed that the migratory behaviour of CAR-T cells differs from that of T cells under confined conditions and that biomechanical cues, such as cell deformability caused by confinement, can influence the correct infiltration of immune cells into solid tumours during the immune response.",
+ "PMID": "39706163",
+ "Title": "Molecular cell",
+ "ArticleTitle": "LncRNAs chaperoning dynamic protein condensates in cancer cells.",
+ "Abstract": "In this issue of Molecular Cell, Sun et\u00a0al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "T-Lymphocytes",
- "Cell Movement",
- "Immunotherapy, Adoptive",
- "Tumor Microenvironment",
- "Receptors, Chimeric Antigen",
+ "RNA, Long Noncoding",
"Neoplasms",
- "Microfluidics",
- "Lab-On-A-Chip Devices",
- "Cell Line, Tumor"
- ]
+ "Chromosomal Proteins, Non-Histone",
+ "Biomolecular Condensates",
+ "RNA, Ribosomal",
+ "Molecular Chaperones",
+ "Gene Expression Regulation, Neoplastic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
- "PMID": "39732216",
- "Title": "International journal of pharmaceutics",
- "ArticleTitle": "Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals.",
- "Abstract": "Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.",
+ "PMID": "39705969",
+ "Title": "Seminars in cell & developmental biology",
+ "ArticleTitle": "Recent advancement in the spatial immuno-oncology.",
+ "Abstract": "Recent advancements in spatial transcriptomics and spatial proteomics enabled the high-throughput profiling of single or multi-cell types and cell states with spatial information. They transformed our understanding of the higher-order architectures and paired cell-cell interactions within a tumor microenvironment (TME). Within less than a decade, this rapidly emerging field has discovered much crucial fundamental knowledge and significantly improved clinical diagnosis in the field of immuno-oncology. This review summarizes the conceptual frameworks to understand spatial omics data and highlights the updated knowledge of spatial immuno-oncology.",
"Predictions": [
- "Cancer",
- "Cardiovascular diseases"
+ "Cancer"
],
"MeshTerms": [
- "Humans",
- "Antioxidants",
- "Flavonoids",
- "Nanoparticles",
"Animals",
- "Neuroprotective Agents",
- "Cosmeceuticals",
+ "Humans",
+ "Immunotherapy",
+ "Medical Oncology",
"Neoplasms",
- "Biological Availability",
- "Nanoparticle Drug Delivery System",
- "Antineoplastic Agents",
- "Cardiovascular Diseases"
- ]
+ "Tumor Microenvironment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
- "PMID": "39732178",
+ "PMID": "39701326",
"Title": "Biochimica et biophysica acta. Reviews on cancer",
- "ArticleTitle": "Research progress of mitochondria and cytoskeleton crosstalk in tumour development.",
- "Abstract": "During tumour progression, organelle function undergoes dramatic changes, and crosstalk among organelles plays a significant role. Crosstalk between mitochondria and other organelles such as the endoplasmic reticulum and cytoskeleton has focussed attention on the mechanisms of tumourigenesis. This review demonstrates an overview of the molecular structure of the mitochondrial-cytoskeletal junction and its biological interactions. It also presents a detailed and comprehensive description of mitochondrial-cytoskeletal crosstalk in tumour occurrence and development, including tumour cell proliferation, apoptosis, autophagy, metabolic rearrangement, and metastasis. Finally, the application of crosstalk in tumour therapy, including drug combinations and chemoresistance, is discussed. This review offers a theoretical basis for establishing mitochondrial-cytoskeletal junctions as therapeutic targets, and offers novel insights into the future management of malignant tumours.",
+ "ArticleTitle": "Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential.",
+ "Abstract": "Aberrant gene expression due to dysfunction in proteins involved in transcriptional regulation is a hallmark of tumor development. Indeed, targeting transcriptional regulators represents an emerging approach in cancer therapeutics. Lens epithelium-derived growth factor (LEDGF/p75, PSIP1) is a co-transcriptional activator that tethers several proteins to the chromatin. LEDGF/p75 has been implicated in diseases such as HIV infection and KMT2A-rearranged leukemia. Notably, LEDGF/p75 is upregulated in various human cancers including prostate and breast cancer. In this review, we discuss the essential role of LEDGF/p75 in different malignancies and explore its mechanistic contribution to tumorigenesis revealing its potential as a therapeutic target for chemotherapy.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Mitochondria",
+ "Carcinogenesis",
"Neoplasms",
- "Cytoskeleton",
+ "Gene Expression Regulation, Neoplastic",
+ "Intercellular Signaling Peptides and Proteins",
"Animals",
- "Autophagy",
- "Apoptosis",
- "Cell Proliferation"
- ]
+ "Adaptor Proteins, Signal Transducing",
+ "Transcription Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "20"
+ }
},
{
- "PMID": "39732132",
- "Title": "Human immunology",
- "ArticleTitle": "Shedding light on the role of complement C4 activation in cancer.",
- "Abstract": "Complement C4 is a key component in the activation of classical and lectin complement pathways, which are observed in both animal tumor models and cancer patients. While its role in autoimmune disorders has been extensively studied, the functions of complement C4 and its activation in cancer have received inadequate consideration. Recent studies have detected C4 activation in animal tumor models and cancer patients, with its fragment C4d found in cancer tissues and lymph nodes. Elevated C4d levels could be a useful biomarker for detecting various cancers. This review aims to summarize recent developments on the role of complement C4 activation in promoting an immunosuppressive tumor microenvironment, thereby supporting tumor progression and metastasis; C4d as a biomarker; and its potential as a target for cancer immunotherapy. We also conduct a critical evaluation of methods used to measure complement C4 and its activation products, highlighting possible pitfalls and areas for improvement in existing research.",
+ "PMID": "39701269",
+ "Title": "SLAS discovery : advancing life sciences R & D",
+ "ArticleTitle": "Protocol to develop A 3D tumor model for drug testing applications.",
+ "Abstract": "Three-dimensional (3D) tumor models provide physiologically relevant tumor environments and have become a major tool in cancer research and drug discovery. This article presents a protocol for creating a 3D organotypic tumor model by embedding a cancer cell spheroid within a collagen matrix containing dispersed fibroblasts. This model offers significant advantages over the conventional monolayer cell culture, monoculture spheroids of cancer cells, and intermixed co-culture of cancer and stromal cells by mimicking the spatial organization and mechanical properties of a solid tumor. Compatible with robotic automation, our protocol significantly enhances reproducibility and scalability of creating a tumor model to study tumor-stromal interactions and test therapeutic compounds.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
+ "Spheroids, Cellular",
+ "Coculture Techniques",
"Neoplasms",
- "Animals",
- "Complement Activation",
+ "Drug Screening Assays, Antitumor",
+ "Cell Line, Tumor",
"Tumor Microenvironment",
- "Complement C4",
- "Biomarkers, Tumor",
- "Immunotherapy",
- "Complement C4b",
- "Peptide Fragments"
- ]
+ "Antineoplastic Agents",
+ "Cell Culture Techniques",
+ "Fibroblasts",
+ "Stromal Cells"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "20"
+ }
},
{
- "PMID": "39731918",
- "Title": "Cell reports. Medicine",
- "ArticleTitle": "Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.",
- "Abstract": "Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N\u00a0= 54). Single-cell RNA-seq and T\u00a0cell receptor sequencing (TCR-seq) reveal that CD8",
+ "PMID": "39701038",
+ "Title": "Cell systems",
+ "ArticleTitle": "Metabolic immunoengineering approaches to enhance CD8 T\u00a0cell-based cancer immunotherapy.",
+ "Abstract": "Many cancer immunotherapies rely on robust CD8 T\u00a0cells capable of eliminating cancer cells and establishing long-term tumor control. Recent insights into immunometabolism highlight the importance of nutrients and metabolites in T\u00a0cell activation and differentiation. Within the tumor microenvironment (TME), CD8 tumor-infiltrating lymphocytes (TILs) undergo metabolic adaptations to survive but compromise their effector function and differentiation. Targeting metabolism holds promise for enhancing CD8 T\u00a0cell-mediated antitumor immunity. Here, we overview the metabolic features of CD8 TILs and their impact on T\u00a0cell effector function and differentiation. We also highlight immunoengineering strategies by leveraging the Yin-Yang of metabolic modulation for improving cancer immunotherapy.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Biomarkers, Tumor",
- "Immunotherapy",
- "Tumor Microenvironment",
"CD8-Positive T-Lymphocytes",
- "Leukocytes, Mononuclear",
- "Male",
- "Female",
- "Receptors, Antigen, T-Cell",
"Neoplasms",
- "Middle Aged",
- "Transcriptome"
- ]
+ "Immunotherapy",
+ "Tumor Microenvironment",
+ "Lymphocytes, Tumor-Infiltrating",
+ "Animals",
+ "Cell Differentiation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "20"
+ }
},
{
- "PMID": "39731836",
- "Title": "Biomaterials advances",
- "ArticleTitle": "Anti-miR21-conjugated DNA nanohydrogel for enhanced cancer therapy.",
- "Abstract": "MicroRNAs (miRNAs) are non-coding, endogenous small single-stranded RNA molecules involved in post-transcriptional regulation of gene expression. It has been demonstrated that dysregulation of miRNA plays a major role in tumor formation, proliferation, and metastasis. Therefore, the delivery of anti-miRNA oligonucleotides to block the activity of these oncogenic miRNAs is a high-potential anti-cancer therapy approach. In particular, miRNA-21 (miR-21) can be an excellent target as it is an oncogenic miRNA that is upregulated in various cancers including glioblastoma, breast cancer, and colon cancer. However, anti-miRNAs are unstable in the physiological environment and have low cell membrane permeability, making it difficult to accumulate at certain concentrations to have anti-cancer effects within cancer cells. To overcome these difficulties, we developed anti-miR-21 functionalized DNA hydrogel (amiR-21 Dgel). We confirmed the improved physiological stability of amiR-21 Dgel in vitro, and observed that it blocked up to 96.6\u00a0% of miR-21 in HeLa cells, and reduced cell viability down to 77.9\u00a0% for 72\u00a0h. In particular, RT-qPCR analysis demonstrated that blocking of miR-21 induces increased mRNA expression of the tumor suppressor genes, PTEN and PDCD4 by 6.23- and 6.87-fold, respectively. In addition, the Dgel can act as a drug delivery vehicle, intercalating anticancer drugs such as doxorubicin (Dox) to be delivered into cells. DOX, an anticancer drug, showed a synergistic anticancer effect with amiR-21, which was delivered together. We expect that this approach will be a convenient to optimization and highly effective strategy for anticancer therapy employing antisense miRNAs.",
+ "PMID": "39699524",
+ "Title": "Historia, ciencias, saude--Manguinhos",
+ "ArticleTitle": "The \"Prudente Plan:\" a S\u00e3o Paulo plan for the fight against cancer in Brazil, 1934-1954.",
+ "Abstract": "This article investigates the strategies employed by Ant\u00f4nio Prudente to develop an initiative aimed at combating cancer throughout Brazil, based on his experience in the state of S\u00e3o Paulo. The approach used in the analysis draws on both the historiographical literature and primary sources, focusing on the period from 1934, when the S\u00e3o Paulo Association for the Fight against Cancer was founded, to 1954, when Prudente was appointed director of the National Cancer Service. The study highlights the disputes between cancerologists from the Union and S\u00e3o Paulo, highlighting the uniqueness of the S\u00e3o Paulo proposal, marked by a combination of liberal ideals and the sentiment of \"Paulistaness.\"",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Brazil",
+ "History, 20th Century",
"Humans",
- "MicroRNAs",
- "Hydrogels",
- "HeLa Cells",
- "DNA",
- "Doxorubicin",
- "PTEN Phosphohydrolase",
- "Cell Survival",
- "Neoplasms",
- "Apoptosis Regulatory Proteins",
- "RNA-Binding Proteins",
- "Antineoplastic Agents",
- "Gene Expression Regulation, Neoplastic"
- ]
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731788",
- "Title": "European journal of medicinal chemistry",
- "ArticleTitle": "Recent progress in the development of peptide-drug conjugates (PDCs) for cancer therapy.",
- "Abstract": "Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides, linkers, and payloads, which possess favorable targeting capability and can deliver enough payloads to the tumor sites with minimized impact on healthy tissues. However, only a few PDCs have been approved for clinical use so far. To advance the research on PDCs, this review summarizes the approved PDCs, and PDCs in clinical and preclinical stages based on the payload types. Additionally, the biological activity and pharmacokinetic properties of preclinical PDCs are detailedly described. Lastly, the challenges and future development directions of PDCs are discussed. This review aims to inspire insights into the development of PDCs for cancer treatment.",
+ "PMID": "39697341",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Targeting extracellular matrix stiffness for cancer therapy.",
+ "Abstract": "The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. Among them, abnormal changes in tissue stiffness hinder drug delivery, inhibit infiltration of immune killer cells to the tumor site, and contribute to tumor resistance to immunotherapy. Therefore, targeting tissue stiffness to increase the infiltration of drugs and immune cells can offer a powerful support and opportunities to improve the immunotherapy efficacy in solid tumors. In this review, we discuss the mechanical properties of tumors, the impact of a stiff TME on tumor cells and immune cells, and the strategies to modulate tumor mechanics.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Animals",
"Humans",
+ "Drug Delivery Systems",
+ "Extracellular Matrix",
+ "Immunotherapy",
"Neoplasms",
- "Antineoplastic Agents",
- "Peptides",
- "Animals",
- "Drug Development",
- "Molecular Structure"
- ]
+ "Tumor Microenvironment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731736",
- "Title": "Bioinformatics (Oxford, England)",
- "ArticleTitle": "VarNMF: non-negative probabilistic factorization with source variation.",
- "Abstract": "Code is available at https://github.com/Nir-Friedman-Lab/VarNMF.",
+ "PMID": "39696541",
+ "Title": "Genome biology",
+ "ArticleTitle": "SyntheVAEiser: augmenting traditional machine learning methods with VAE-based gene expression sample generation for improved cancer subtype predictions.",
+ "Abstract": "The accuracy of machine learning methods is often limited by the amount of training data that is available. We proposed to improve machine learning training regimes by augmenting datasets with synthetically generated samples. We present a method for synthesizing gene expression samples and test the system's capabilities for improving the accuracy of categorical prediction of cancer subtypes. We developed SyntheVAEiser, a variational autoencoder based tool that was trained and tested on over 8000 cancer samples. We have shown that this technique can be used to augment machine learning tasks and increase performance of recognition of underrepresented cohorts.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Machine Learning",
"Humans",
- "Algorithms",
"Neoplasms",
- "Genomics"
- ]
+ "Gene Expression Profiling",
+ "Software",
+ "Gene Expression Regulation, Neoplastic",
+ "Algorithms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731651",
- "Title": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
- "ArticleTitle": "Effect of Qigong exercise on quality of life and cortisol in patients with cancer: a non-randomized controlled trial.",
- "Abstract": "Six-month Guolin Qigong could improve quality of life, physical function, and pain, and have a beneficial effect on the well-being of cancer patients. Further studies are warranted to confirm these results.",
+ "PMID": "39694781",
+ "Title": "Hematology/oncology clinics of North America",
+ "ArticleTitle": "Patient-Reported Outcomes in Radiation Oncology.",
+ "Abstract": "Patient-reported outcomes (PROs) assessments arguably provide the most accurate description of the patient experience, as they are directly derived from the patient without the filter of a provider. Utilizing instruments to assess PROs in radiation oncology enables a provider to measure pretreatment, on-treatment, and posttreatment symptoms. In the clinic, PROs are supplemental to physician-derived ratings that help create a complete clinical picture of a patient at a given time point to inform shared decision-making. A compilation of PROs that arise within trials, specific for given treatment regimes, will be invaluable for patients faced with choosing between options.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Quality of Life",
- "Female",
- "Male",
- "Hydrocortisone",
- "Qigong",
- "Middle Aged",
+ "Patient Reported Outcome Measures",
+ "Radiation Oncology",
"Neoplasms",
- "Aged",
- "Adult"
- ]
+ "Quality of Life"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731471",
- "Title": "Iranian journal of immunology : IJI",
- "ArticleTitle": "Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein.",
- "Abstract": "These immunotoxin structures showed therapeutic potential against GRP78-expressing cancers, making them suitable candidates for targeted therapy pending in vivo studies.",
+ "PMID": "39694780",
+ "Title": "Hematology/oncology clinics of North America",
+ "ArticleTitle": "Gene Signatures and Oncology Treatment Implications.",
+ "Abstract": "Gene expression signatures (GES) are a powerful tool in oncology used for classification, prognostication, and therapeutic response prediction of malignancies. In this article, we review the disease site guidelines by the National Comprehensive Cancer Network that use GES for treatment planning and clinical use. We identified 4 cancer types for which treatment decisions are frequently influenced by GES. Future developments in the field of GES are likely to include expanded data sources to personalize radiation therapy dosing and predict response to immunotherapy. Ongoing challenges in GES may be addressed to ensure that all patients with cancer benefit from precision oncology.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Endoplasmic Reticulum Chaperone BiP",
- "Single-Domain Antibodies",
- "Recombinant Fusion Proteins",
- "Immunotoxins",
- "Apoptosis",
- "Exotoxins",
- "Animals",
- "Heat-Shock Proteins",
- "Cell Line, Tumor",
- "Camelus",
- "Breast Neoplasms",
- "Female",
- "ADP Ribose Transferases",
- "Bacterial Toxins",
- "HEK293 Cells",
- "Pseudomonas aeruginosa Exotoxin A",
"Neoplasms",
- "MCF-7 Cells",
- "Virulence Factors"
- ]
+ "Precision Medicine",
+ "Transcriptome",
+ "Gene Expression Regulation, Neoplastic",
+ "Gene Expression Profiling",
+ "Medical Oncology",
+ "Prognosis",
+ "Biomarkers, Tumor",
+ "Immunotherapy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731178",
- "Title": "Journal of experimental & clinical cancer research : CR",
- "ArticleTitle": "Cancer Organoids as reliable disease models to drive clinical development of novel therapies.",
- "Abstract": "On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled \"Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies,\" took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells interacting within their microenvironments. These models address critical unmet needs in precision medicine, particularly in aiding clinical decision-making. The rapid development of these human tissue avatars has enabled advanced modeling of cellular alterations in disease states and the screening of compounds to uncover novel therapeutic pathways.Throughout the event, distinguished speakers shared their expertise and research findings, illustrating how organoids are transforming our understanding of treatment resistance, metastatic dynamics, and the interaction between tumors and the surrounding microenvironment.This conference served as a pivotal opportunity to strengthen international collaborations and spark innovative translational approaches. Its goal was to accelerate the shift from preclinical research to clinical application, paving the way for increasingly personalized and effective cancer therapies.",
+ "PMID": "39692279",
+ "Title": "Scandinavian journal of urology",
+ "ArticleTitle": "How to improve cancer care by use of guidelines and quality registers.",
+ "Abstract": "N/A.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Organoids",
+ "Registries",
"Neoplasms",
- "Tumor Microenvironment",
- "Precision Medicine",
- "Animals"
- ]
+ "Practice Guidelines as Topic",
+ "Quality Improvement"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39731135",
- "Title": "Molecular cancer",
- "ArticleTitle": "Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade.",
- "Abstract": "The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immune microenvironment. Here, we performed an extensive clinical and bioinformatic analysis to explore the association between KDM5 mutation and tumor immunity and its impact on the outcomes in pan-cancer immunotherapy. In 2943 patients across 12 tumor types treated with immune checkpoint inhibitors, KDM5-mutant tumors were associated with favorable overall survival (hazard ratio, 0.72; 95% confidence interval, 0.59-0.87; P\u2009=\u20090.004) and objective response rate (41.7% vs. 26.8%; P\u2009=\u20090.001). Further multi-omics analysis revealed KDM5 mutation was related to boosted tumor immunogenicity, enriched infiltration of immune cells, and improved immune responses. In summary, KDM5 mutation indicates enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade. These results have implication for treatment decision-making and developing immunotherapy for personalized care.",
+ "PMID": "39690092",
+ "Title": "Bulletin du cancer",
+ "ArticleTitle": "[A 2024\u00a0inventory in oncology news].",
+ "Abstract": "The editorial board of the Bulletin du cancer has compiled a summary of the news from 2024\u00a0in oncology, based on the main results presented at international congresses or published over the past year. After a year marked by the success of the Olympic Games, the selection of data is presented and discussed in podiums of three main results by topic. Emphasis is placed on studies that have an immediate impact on practice and on data that raise important questions for the year 2025.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Immune Checkpoint Inhibitors",
"Neoplasms",
- "Mutation",
- "Tumor Microenvironment",
- "Histone Demethylases",
- "Biomarkers, Tumor",
- "Prognosis",
- "Immunotherapy"
- ]
+ "Medical Oncology",
+ "Female",
+ "Male",
+ "Congresses as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39731127",
- "Title": "Molecular cancer",
- "ArticleTitle": "Advances in A-to-I RNA editing in cancer.",
- "Abstract": "RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine deaminase acting on RNA (ADAR) in double-stranded RNA (dsRNA). With advancements in RNA sequencing technologies, the role of A-to-I modification in cancer has garnered increasing attention. Research indicates that the levels and specific sites of A-to-I editing are significantly altered in many malignant tumors, correlating closely with tumor progression. This editing occurs in both coding and noncoding regions of RNA, influencing signaling pathways involved in cancer development. These modifications can either promote or suppress cancer progression through several mechanisms, including inducing non-synonymous amino acid mutations, altering the immunogenicity of dsRNAs, modulating mRNA interactions with microRNAs (miRNAs), and affecting the splicing of circular RNAs (circRNAs) as well as the function of long non-coding RNAs (lncRNAs). A comprehensive understanding of A-to-I RNA editing is crucial for advancing the diagnosis, treatment, and prognosis of human cancers. This review explores the regulatory mechanisms of A-to-I editing in cancers and examines their potential clinical applications. It also summarizes current research, identifies future directions, and highlights potential therapeutic implications.",
+ "PMID": "39689683",
+ "Title": "Current biology : CB",
+ "ArticleTitle": "Jewel Plummer Cobb: A trailblazing life of impact.",
+ "Abstract": "Stacey Finley commemorates the life and work of biologist Jewel Plummer Cobb, whose outstanding contributions to cancer research, education and advocacy had far-reaching impact.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "History, 20th Century",
+ "History, 21st Century",
"Humans",
- "RNA Editing",
- "Neoplasms",
- "Inosine",
- "Adenosine",
- "Animals",
- "Gene Expression Regulation, Neoplastic",
- "Adenosine Deaminase",
- "Biomarkers, Tumor",
- "MicroRNAs"
- ]
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39731088",
- "Title": "BMC palliative care",
- "ArticleTitle": "Specialized palliative outpatient clinic care involvement associated with decreased end-of-life hospital costs in cancer patients, a single center study.",
- "Abstract": "Our results provide first indications that a contact to specialist palliative care in an outpatient clinic may reduce end-of-life hospital care costs in hospital-deceased cancer patients.",
+ "PMID": "39689426",
+ "Title": "Journal of the National Comprehensive Cancer Network : JNCCN",
+ "ArticleTitle": "NCCN Guidelines\u00ae Insights: Survivorship, Version 2.2024.",
+ "Abstract": "The NCCN Guidelines for Survivorship include recommendations for screening, evaluation, and treatment of psychosocial and physical problems resulting from adult-onset cancer and its treatment. They also include recommendations to promote healthy behaviors and immunizations in survivors and provide a framework for care coordination. These NCCN Guidelines Insights summarize the panel's current recommendations regarding sexual health and fertility.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Retrospective Studies",
- "Palliative Care",
- "Aged",
- "Middle Aged",
+ "Survivorship",
"Neoplasms",
- "Terminal Care",
- "Aged, 80 and over",
- "Finland",
- "Hospital Costs",
- "Ambulatory Care Facilities",
- "Registries",
- "Adult",
- "Ambulatory Care"
- ]
+ "Cancer Survivors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39731068",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.",
- "Abstract": "Among the general American population, baseline CMI levels exhibited an L-shaped nonlinear relationship with all-cause mortality, and the threshold value was 0.98. What's more, CMI may become an effective indicator for CVD, cancer, and all-cause mortality prediction. Further investigation is essential to confirm our findings.",
+ "PMID": "39684799",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Molecular Biology of Cancer-Interplay of Malignant Cells with Emerging Therapies.",
+ "Abstract": "Cancer is currently one of the leading causes of death worldwide, and according to data from the World Health Organization reported in 2020, it ranks as the second leading cause of death globally, accounting for 10 million fatalities [...].",
"Predictions": [
- "Cancer",
- "Cardiovascular diseases"
+ "Cancer"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Nutrition Surveys",
- "Neoplasms",
- "Adult",
- "Aged",
- "Triglycerides",
- "Cause of Death",
- "Waist Circumference",
- "Cholesterol, HDL",
- "Proportional Hazards Models",
- "Kaplan-Meier Estimate",
- "Body Mass Index",
- "Risk Factors"
- ]
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "17"
+ }
},
{
- "PMID": "39731019",
- "Title": "BMC bioinformatics",
- "ArticleTitle": "AEGAN-Pathifier: a data augmentation method to improve cancer classification for imbalanced gene expression data.",
- "Abstract": "AEGAN-Pathifier shows improved performance on the imbalanced datasets GSE25066, GSE20194, BRCA and Liver24. Results from various classifiers indicate that AEGAN-Pathifier has good generalization capability.",
+ "PMID": "39676363",
+ "Title": "The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics",
+ "ArticleTitle": "\"Unjustified Partiality or Impartial Bias? Reckoning with Age and Disability Discrimination in Cancer Clinical Trials\".",
+ "Abstract": "In this issue, Zakout discusses European Union (EU) legal provisions for inclusion of patients of all types in clinical trials. Shee highlights the unfortunate failure to include adequate numbers of older adults and adults with disabilities in clinical trials of anti-cancer agents. We agree with her argument that this is an ethical issue as well as a scientific and clinical issue.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
+ "Persons with Disabilities",
+ "Clinical Trials as Topic",
"Neoplasms",
- "Algorithms",
- "Deep Learning",
- "Gene Expression Profiling",
- "Computational Biology",
- "Databases, Genetic"
- ]
+ "European Union",
+ "Ageism",
+ "Patient Selection",
+ "Aged",
+ "Disability Discrimination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
},
{
- "PMID": "39730977",
- "Title": "Journal of the Egyptian National Cancer Institute",
- "ArticleTitle": "Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges.",
- "Abstract": "Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics. The benefits and drawbacks of certain green synthesis techniques, such as plant-mediated, microorganism-mediated, and other environmentally friendly processes, are discussed. Moreover, a thorough discussion is given of CuNPs' biological uses, including their antibacterial activity, anticancer potential, drug transport, and bioimaging capabilities. Furthermore, difficulties and prospects for the application of green-synthesised CuNPs in biomedicine are discussed.",
+ "PMID": "39676362",
+ "Title": "The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics",
+ "ArticleTitle": "Unjustified Partiality or Impartial Bias? Reckoning with Age and Disability Discrimination in Cancer Clinical Trials.",
+ "Abstract": "The exclusion of the elderly and people with disabilities from cancer clinical research without appropriate justification is discriminatory and is at odds with the ethos of EU principles, laws and research regulations. It further limits study generalizability. Several primary EU laws fronted by the European Charter prohibit engaging in disparate impact discrimination on the grounds of age and disability in all of EU tasks.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Copper",
"Humans",
- "Metal Nanoparticles",
- "Green Chemistry Technology",
+ "Persons with Disabilities",
"Neoplasms",
- "Antineoplastic Agents",
- "Drug Resistance, Neoplasm"
- ]
+ "Ageism",
+ "Clinical Trials as Topic",
+ "European Union",
+ "Aged",
+ "Patient Selection",
+ "Prejudice",
+ "Disability Discrimination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
},
{
- "PMID": "39730928",
- "Title": "Scientific reports",
- "ArticleTitle": "Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.",
- "Abstract": "Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time. More important, the neurotransmitter serotonin was encapsulated on the surface of ZIF-8/DOX by oxidative polymerization, which can effectively avoid the premature leakage of DOX in the blood circulation. And the formed polyserotonin shell has superior photothermal conversion performance, as well as the adsorption property of polyserotonin shell was utilized to load imiqumod. When FM@IQ/PST&ZIF-8/DOX entered the tumor tissue, the surface modified folate molecules can specifically bind to the folate receptors on the surface of tumor cells to improve FM@IQ/PST&ZIF-8/DOX uptake by tumor cells. In vitro and in vivo results showed that FM@IQ/PST&ZIF-8/DOX nanoplatform could generate a large amount of heat under near-infrared light irradiation, and then induce the apoptosis of tumor cells, release tumor associated antigens, and effectively solve the problem of tumor heterogeneity. In addition, the loaded imiquimod could effectively improve the immunosuppressive microenvironment, enhance the body's anti-tumor immune response, to inhibit tumor metastasis and recurrence. Therefore, the novel FM@IQ/PST&ZIF-8/DOX nanoplatform designed in this research can not only achieve controllable and precise drug release, but also it is expected to become a promising new strategy for tumor treatment and provide corresponding inspiration for the later research and development of environment-responsive drugs.",
+ "PMID": "39674173",
+ "Title": "Med (New York, N.Y.)",
+ "ArticleTitle": "At the right time: Moving precision therapy to newly diagnosed cancer.",
+ "Abstract": "Precision oncology aims to match the right drug(s) to the right patient. Equally important is ensuring that precision therapies are offered at the right time. Transformative, rather than incremental, outcome improvement may require treatment at diagnosis rather than in the advanced/metastatic setting after genomic evolution.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Doxorubicin",
- "Animals",
- "Mice",
"Humans",
- "Cell Line, Tumor",
- "Immunotherapy",
+ "Precision Medicine",
"Neoplasms",
- "Drug Delivery Systems",
- "Nanoparticles",
- "Tumor Microenvironment",
- "Biomimetics",
- "Imiquimod",
- "Serotonin",
- "Antineoplastic Agents",
- "Combined Modality Therapy",
- "Mice, Inbred BALB C"
- ]
+ "Antineoplastic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "15"
+ }
},
{
- "PMID": "39730772",
- "Title": "Scientific reports",
- "ArticleTitle": "Mediating and moderating factors between stigma and adaptability to return to work for cancer survivors.",
- "Abstract": "Adaptability to return to work is a process by which cancer survivors(CSs) utilize accessible resources to reconstruct themselves. While the stigma, financial situation and social support are known to influence their adaptability to return to work, the mechanisms by which these factors work remain unclear. This study proposes a moderated mediation model to signify a pathway linking stigma to the adaptability to return to work. Data were analyzed using the PROCESS macro for R version 4.3.1. A total of 238 CSs, aged between 18 and 60 years (73.5% female), of whom 42.1% had returned to work, completed the ARTWS, SIS, COST-PROM, SSRS, HeLMS. Stigma had a negative associations on the adaptability to return to work. Both financial toxicity and social support mediated the relationship between stigma and the adaptability to return to work. Health literacy moderated both the direct pathway and the second half of the pathway mediated by financial toxicity. Specifically, the negative effects of stigma and financial toxicity on the adaptability to return to work were significantly attenuated when health literacy levels were high. CSs with higher health literacy may not experience excessive stigma, and experience less financial toxicity than those with lower health literacy. CSs possessing greater social support will be more effective in utilizing external resources to buffer the influence of financial toxicity, and thus adapt better to work.",
+ "PMID": "39672756",
+ "Title": "Trends in cancer",
+ "ArticleTitle": "Intratumoral immune cell manipulations as a strategy to enhance cancer vaccine efficiency.",
+ "Abstract": "Shortcomings in cancer vaccine development are attributable to weak and transient anti-tumor cellular responses in the tumor microenvironment. This restriction of efficacy may be due to an intratumoral immunosuppressive milieu, consisting of regulatory T cells, M2 macrophages, and myeloid derived suppressor cells. Here, we analyze recent advances and propose future directions in the modulation of cellular state propensities combined with cancer vaccines.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Cancer Survivors",
- "Female",
- "Male",
- "Adult",
- "Middle Aged",
- "Return to Work",
- "Social Stigma",
- "Social Support",
- "Adolescent",
- "Young Adult",
- "Adaptation, Psychological",
- "Health Literacy",
+ "Cancer Vaccines",
+ "Tumor Microenvironment",
"Neoplasms",
- "Surveys and Questionnaires"
- ]
+ "Myeloid-Derived Suppressor Cells",
+ "Animals",
+ "T-Lymphocytes, Regulatory",
+ "Immunotherapy",
+ "Macrophages",
+ "Vaccine Efficacy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "14"
+ }
},
{
- "PMID": "39730706",
- "Title": "Scientific reports",
- "ArticleTitle": "Death and hospital contact in a cohort from Thybor\u00f8n-Harbo\u00f8re an environmentally contaminated site in Denmark.",
- "Abstract": "We studied mortality and hospital contact in people from Thybor\u00f8n-Harbo\u00f8re, an environmentally contaminated fishing community on the Danish West Coast. The population and a comparison group from other fishing communities on the Danish West Coast were identified from historical data in the Central Population Register. All persons were followed up for death and hospital contacts to March 2023. Event rates were compared with Poisson regression; adjusted rate ratios (aRR); and 95% confidence interval (CI). The old cohort included inhabitants in Thybor\u00f8n-Harbo\u00f8re in 1968-1970 before pollution was controlled; 4914 persons/2485 deaths. All-cause mortality, aRR 1.06 (95% CI 1.01-1.11), and cancer mortality, aRR 1.17 (95% CI 1.05-1.30), were elevated; especially for kidney cancer aRR 1.82 (95% CI 1.07-3.12). Hospital contacts were elevated for psychiatric disorders; with an aRR of 4.07 (95% CI 1.41-11.72) for anxiety in men. As there is still considerable concern in the area about possible health consequences from stored chemicals, we included also a new cohort of newborn and immigrants to the area in 1990-2006; 2933 persons/302 deaths. All-cause mortality, aRR 1.26 (1.11-1.43) (men 1.15 and women 1.44), and cancer mortality, aRR 1.47 (95% CI 1.14-1.89) were elevated. Hospital contacts were elevated for ischemic heart disease/heart attack and indicated for autism/obsessive compulsory disorder in boys. In conclusion, mortality data confirmed incidence data of excess kidney cancer in the old cohort. The new cohort had a generally elevated mortality, possibly indicating selective immigration from other parts of Denmark. However, the new cohort is still relatively young, and the mortality pattern needs to be monitored.",
+ "PMID": "39672167",
+ "Title": "Cancer cell",
+ "ArticleTitle": "A metabolic pathway for improving adoptive cellular therapy.",
+ "Abstract": "In this issue of Cancer Cell, Qiu et\u00a0al. use single-cell metabolic analysis to identify reduced mannose metabolism as a previously unknown feature of exhausted T\u00a0cells. This metabolic pathway can be targeted to enhance memory and persistence of adoptively transferred T\u00a0cells, resulting in improved anti-tumor efficacy.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Denmark",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
- "Aged",
- "Cohort Studies",
- "Environmental Pollution",
- "Young Adult",
- "Child, Preschool",
- "Infant, Newborn",
- "Environmental Exposure",
- "Adolescent",
- "Child",
- "Infant",
- "Aged, 80 and over",
+ "Immunotherapy, Adoptive",
+ "Metabolic Networks and Pathways",
+ "T-Lymphocytes",
"Neoplasms",
- "Cause of Death"
- ]
+ "Animals",
+ "Mannose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "14"
+ }
},
{
- "PMID": "39730699",
- "Title": "Scientific reports",
- "ArticleTitle": "Comparative evaluation of feature reduction methods for drug response prediction.",
- "Abstract": "Personalized medicine aims to tailor medical treatments to individual patients, and predicting drug responses from molecular profiles using machine learning is crucial for this goal. However, the high dimensionality of the molecular profiles compared to the limited number of samples presents significant challenges. Knowledge-based feature selection methods are particularly suitable for drug response prediction, as they leverage biological insights to reduce dimensionality and improve model interpretability. This study presents the first comparative evaluation of nine different knowledge-based and data-driven feature reduction methods on cell line and tumor data. Our analysis employs six distinct machine learning models, with a total of more than 6,000 runs to ensure a robust evaluation. Our findings indicate that transcription factor activities outperform other methods in predicting drug responses, effectively distinguishing between sensitive and resistant tumors for seven of the 20 drugs evaluated.",
+ "PMID": "39672165",
+ "Title": "Cancer cell",
+ "ArticleTitle": "Advances in liquid biopsy: From exploration to practical application.",
+ "Abstract": "Liquid biopsy has received tremendous attention as a non-invasive approach for detecting and tracking cancer. Here, we discuss the latest work on circulating tumor DNA and circulating tumor cells with respect to clinical applications, including cancer screening, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Liquid Biopsy",
"Humans",
- "Machine Learning",
- "Antineoplastic Agents",
- "Precision Medicine",
+ "Circulating Tumor DNA",
"Neoplasms",
- "Cell Line, Tumor"
- ]
+ "Neoplastic Cells, Circulating",
+ "Biomarkers, Tumor",
+ "Early Detection of Cancer"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "14"
+ }
},
{
- "PMID": "39730637",
- "Title": "Scientific reports",
- "ArticleTitle": "Characterising immune-related adverse events in different types of cancer among Chinese patients receiving immune checkpoint inhibitors.",
- "Abstract": "Immune checkpoint inhibitors (ICIs) have been approved for monotherapy and combined therapy with chemotherapy and/or radiotherapy in China since 2018. The number of patients receiving ICIs has significantly increased in recent years, and the collection and analysis of this data are crucial for a comprehensive understanding of their clinical outcomes and adverse effects. The effects of ICIs may vary among different ethnic groups, and there is a lack of such data in the Chinese population. This study aimed to investigate the occurrence rate of various types of immune-related adverse events (irAEs) of ICIs in cancer survivors with different types of cancer and explore the associated risk factors. Demographic data, cancer type, dosage, Eastern Cooperative Oncology Group Performance Score (ECOG-PS), and details of irAEs were collected from 120 participants who underwent ICI treatment. Descriptive statistics were used to summarise the patient population characteristics, while t-tests and Chi-square tests assessed associations between variables. Multiple logistic regression evaluated the relationships between independent variables and the likelihood of experiencing irAEs. The results indicated that the occurrence of less severe G1 and G2 irAEs was 25%, while more severe G3 to G5 irAEs accounted for 5.8% of the total. Among the irAEs, skin toxicity had the highest incidence rate (14.2%), followed by gastrointestinal toxicity (6.7%), and endocrine toxicity had the lowest incidence rate of 2.5%. The multiple logistic regression model revealed that patients with ECOG-PS\u2009\u2265\u20092 are over five times more likely to experience irAEs compared to those with lower ECOG-PS (OR: 5.03, 95% CI: 1.05-24.17). Additionally, patients with cancer stage IV have 11.47 times the odds of experiencing irAEs (OR: 11.47, 95% CI: 1.05-24.17). In conclusion, a substantial proportion of patients receiving ICIs experienced irAEs. Patients with an ECOG-PS score of \u2265\u20092 and advanced cancer stage are at increased risk for these events, necessitating close monitoring by healthcare professionals. The identification of skin and gastrointestinal toxicities as the most common irAEs revealed the need for targeted education for the patients and their carers to recognise and manage these issues. Furthermore, our findings, in conjunction with existing literature, may guide future research on predictive modelling for high-risk patients receiving ICIs.",
+ "PMID": "39662494",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[(Over-)living with cancer: secondary malignancies (incl. genetics)].",
+ "Abstract": "Secondary malignancies (secondary cancers) are malignant diseases that occur at a certain time after cancer treatment. The malignant neoplasms can occur anywhere from 2 months to decades after cancer treatment. In addition, multiple tumor diseases can also develop due to a hereditary tendency to tumors. This article provides an overview of the causes, early detection and individual treatment.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Adult",
- "Aged",
- "Female",
"Humans",
- "Male",
- "Middle Aged",
- "China",
- "Drug-Related Side Effects and Adverse Reactions",
- "East Asian People",
- "Immune Checkpoint Inhibitors",
- "Neoplasms",
- "Risk Factors"
- ]
+ "Neoplasms, Second Primary",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
},
{
- "PMID": "39730328",
- "Title": "Nature communications",
- "ArticleTitle": "A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy.",
- "Abstract": "Immune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate the efficacy of the therapy. The gut microbiome's influence on ICB efficacy is of particular interest due to its modifiability through various interventions. However, gut microbiome biomarkers for ICB response have been inconsistent across different studies. Here, we identify TANB77, an uncultured and distinct bacterial clade, as the most consistent responder-enriched taxon through meta-analysis of ten independent ICB recipient cohorts. Traditional taxonomy fails to distinguish TANB77 from unrelated taxa, leading to its oversight. Mice with higher gut TANB77 abundance, either naturally or through transplantation, show improved response to anti-PD-1 therapy. Additionally, mice injected with TANB77-derived pilin-like protein exhibit improved anti-PD-1 therapy response, providing in vivo evidence for the beneficial role of the pilin-like protein. These findings suggest that pilins from the TANB77 order may enhance responses to ICB therapy across diverse cohorts of cancer patients.",
+ "PMID": "39662492",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[(Surviving) life with cancer: the importance of sport and physical activity].",
+ "Abstract": "As the survival prognosis of cancer patients continues to improve, the improvement in quality of life during and after cancer treatment is becoming increasingly important 1. Exercise therapy has a positive effect on so-called \"patient-reported outcomes\" 2. The combination of endurance training and individualized strength training plays a particularly important role here. There is therefore a need for consistent and comprehensive implementation of quality-assured exercise therapy in everyday clinical practice.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Animals",
- "Gastrointestinal Microbiome",
- "Mice",
- "Immunotherapy",
"Humans",
- "Immune Checkpoint Inhibitors",
- "Female",
- "Fimbriae Proteins",
- "Programmed Cell Death 1 Receptor",
+ "Quality of Life",
+ "Exercise",
"Neoplasms",
- "Mice, Inbred C57BL",
- "Bacteria",
- "Cell Line, Tumor",
- "Male"
- ]
+ "Sports",
+ "Cancer Survivors",
+ "Exercise Therapy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
},
{
- "PMID": "39730320",
- "Title": "Psycho-oncology",
- "ArticleTitle": "Post-Treatment Cancer Survivors' Experience of Social Reintegration: A Systematic Review and Meta-Synthesis.",
- "Abstract": "This study synthesized qualitative evidence related to social reintegration among post-treatment cancer survivors. Cancer survivors took active measures for social reintegration. In turn, social reintegration also had a positive consequence on cancer survivors. Survivors had internal and external obstacles and needs in the process of social reintegration. Therefore, practitioners should identify obstacles and needs for social reintegration and develop targeted intervention programs to facilitate the social reintegration of survivors.",
+ "PMID": "39662491",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[Psychological support for people with cancer].",
+ "Abstract": "The number of people living with or after cancer is steadily increasing due to an ageing society and improved cancer treatment. However, once treatment has been completed, the consequences of the disease are often felt for a long time. These affect many different areas of life and often lead to a high level of suffering and need for care. Psycho-oncological support offers effective support for many of those affected.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Cancer Survivors",
- "Social Support",
"Neoplasms",
- "Qualitative Research",
- "Social Adjustment",
- "Social Interaction"
- ]
+ "Social Support",
+ "Adaptation, Psychological",
+ "Psycho-Oncology",
+ "Cancer Survivors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
},
{
- "PMID": "39730153",
- "Title": "BMJ open",
- "ArticleTitle": "Exploring the status of online social support for older adults with cancer: a scoping review protocol.",
- "Abstract": "No ethical approval is needed. The findings will be published in a peer-reviewed journal and presented at conferences.",
+ "PMID": "39645642",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Application of artificial intelligence-based organ contouring software and comparison of results in treatment planning for radiotherapy].",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
+ "Radiotherapy Planning, Computer-Assisted",
+ "Artificial Intelligence",
+ "Software",
+ "Tomography, X-Ray Computed",
+ "Organs at Risk",
"Neoplasms",
- "Social Support",
- "Aged",
- "COVID-19",
- "SARS-CoV-2",
- "Online Social Networking",
- "Research Design",
- "Scoping Reviews As Topic"
- ]
+ "Radiotherapy Dosage",
+ "Algorithms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "8"
+ }
},
{
- "PMID": "39729927",
- "Title": "Cancer genetics",
- "ArticleTitle": "Machine learning analysis of CD4+ T cell gene expression in diverse diseases: insights from cancer, metabolic, respiratory, and digestive disorders.",
- "Abstract": "CD4",
+ "PMID": "39642852",
+ "Title": "Molecular cell",
+ "ArticleTitle": "PRDX6 as an additional piece in the puzzle of selenoprotein synthesis.",
+ "Abstract": "In this issue of Molecular Cell, Ito et\u00a0al. and Chen et\u00a0al. identify peroxiredoxin 6 (PRDX6) as member of the selenoprotein (re)synthesis machinery, thereby linking PRDX6 to ferroptosis susceptibility of cancer cells.",
"Predictions": [
- "Cancer",
- "Chronic respiratory disease"
+ "Cancer"
],
"MeshTerms": [
+ "Selenoproteins",
"Humans",
- "CD4-Positive T-Lymphocytes",
- "Neoplasms",
- "Machine Learning",
- "Digestive System Diseases",
- "Metabolic Diseases",
- "Respiratory Tract Diseases",
- "Gene Expression Profiling",
- "Respiration Disorders"
- ]
+ "Peroxiredoxin VI",
+ "Ferroptosis",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "7"
+ }
},
{
- "PMID": "39729909",
- "Title": "Redox biology",
- "ArticleTitle": "Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer.",
- "Abstract": "The increase in early-stage cancers, particularly gastrointestinal, breast and kidney cancers, has been linked to lifestyle changes such as consumption of processed foods and physical inactivity, which contribute to obesity and diabetes - major cancer risk factors. Conventional treatments such as chemotherapy and radiation often lead to severe long-term side effects, including secondary cancers and tissue damage, highlighting the need for new, safer and more effective therapies, especially for young patients. Weak electromagnetic fields (WEMF) offer a promising non-invasive approach to cancer treatment. While WEMF have been used therapeutically for musculoskeletal disorders for decades, their role in oncology is still emerging. WEMFs affect multiple cellular processes through mechanisms such as the radical pair mechanism (RPM), which alters reactive oxygen species (ROS) levels, mitochondrial function, and glycolysis, among others. This review explores the potential of WEMF in conjunction with reactive oxygen species as a cancer therapy, highlighting WEMFs selective targeting of cancer cells and its non-ionizing nature, which could reduce collateral damage compared to conventional treatments. In addition, synchronization of WEMF with circadian rhythms may further enhance its therapeutic efficacy, as has been demonstrated in other cancer therapies.",
+ "PMID": "39638248",
+ "Title": "Cancer research and treatment",
+ "ArticleTitle": "Identifying Trends in Oncology Research through a Bibliographic Analysis of Cancer Research and Treatment.",
+ "Abstract": "During the celebration of the 50th anniversary of the founding of the Korean Cancer Association, articles published in Cancer Research and Treatment from 2004 to 2023 were assessed based on the subject and design of each study. Based on this analysis, trends in domestic cancer research were inferred and directions were suggested for the future development of Cancer Research and Treatment.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Reactive Oxygen Species",
"Humans",
+ "Medical Oncology",
"Neoplasms",
- "Magnetic Fields",
- "Animals",
- "Mitochondria",
- "Electromagnetic Fields"
- ]
+ "Biomedical Research",
+ "Bibliometrics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "6"
+ }
},
{
- "PMID": "39729775",
- "Title": "Biomaterials",
- "ArticleTitle": "In situ production and precise release of bioactive GM-CSF and siRNA by engineered bacteria for macrophage reprogramming in cancer immunotherapy.",
- "Abstract": "In the immunosuppressive tumor microenvironment (TME), tumor-associated macrophages (TAMs) predominantly exhibit an immunosuppressive M2 phenotype, which facilitates tumor proliferation and metastasis. Although current strategies aimed at reprogramming TAMs hold promise, their sustainability and effectiveness are limited due to repeated injections. Herein, a bacterial therapy platform containing two engineered strains was developed. One strain was engineered to produce and secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) to promote M2-like TAMs repolarization to M1-like TAMs, while the other strain was designed to secrete small interfering RNA (siRNA) targeting signal regulatory protein \u03b1 (SIRP\u03b1). The two strains can continuously and efficiently produce bioactive therapeutic agents in situ, exerting a sustained and synergistic therapeutic effect in TAMs to inhibit tumor growth. To enhance treatment efficacy, optogenetic strategy was implemented to effectively control the production of GM-CSF, and outer membrane vesicles (OMVs) produced by engineered bacteria were utilized to protect the siRNA from degradation in the external environment. The experimental results indicated that the bacterial therapy platform could continuously produce and release bioactive GM-CSF and SIRP\u03b1 siRNA, exhibiting significant therapeutic activity. In vivo experiments further demonstrated that this platform showed more sustained and stable therapeutic effects compared to conventional drug therapies. Additionally, the combination of these two engineered strains yielded the highest ratio of M1/M2 TAMs (0.80) and the lowest ratio of F4/80",
+ "PMID": "39637346",
+ "Title": "JCO global oncology",
+ "ArticleTitle": "Potential Negative Impacts of the CCI4EU Initiative on Spain.",
+ "Abstract": "Spain's cancer care is at a crossroads! The CCI4EU initiative promises progress, but could it widen the gap for rural and vulnerable communities? Balancing innovation with access is crucial! #CancerCare #HealthcareAccess #Spain #CCI4EU #HealthEquality.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Granulocyte-Macrophage Colony-Stimulating Factor",
- "Animals",
- "RNA, Small Interfering",
- "Immunotherapy",
- "Mice",
- "Macrophages",
- "Cellular Reprogramming",
- "Mice, Inbred C57BL",
- "Neoplasms",
- "Tumor Microenvironment",
- "Cell Line, Tumor",
+ "Spain",
"Humans",
- "Tumor-Associated Macrophages",
- "Female",
- "RAW 264.7 Cells"
- ]
+ "Neoplasms",
+ "Health Services Accessibility",
+ "Medical Oncology",
+ "Rural Population"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
- "PMID": "39729479",
- "Title": "PloS one",
- "ArticleTitle": "The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells.",
- "Abstract": "Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene expression levels represent the average measure from multiple cell populations. Alternatively, single cell RNA sequencing can dive into unique cell populations transcriptome, facilitating the identification of specific targets. Here, we generated Tumor-Infiltrating regulatory T cells (TI-Tregs) and exhausted T cells (Tex) gene signatures from a single cell RNA-seq pan-cancer T cell atlas. To overcome noise and sparsity inherent to single cell transcriptomics, we then propagated the gene signatures by diffusion in a protein-protein interaction network using the Patrimony high-throughput computing platform. This methodology enabled the refining of signatures by rescoring genes based on their biological connectivity and shed light not only on processes characteristics of TI-Treg and Tex development and functions but also on their immunometabolic specificities. The combined use of single cell transcriptomics and network propagation may thus represent an innovative and effective methodology for the characterization of cell populations of interest and eventually the development of new therapeutic strategies in immuno-oncology.",
+ "PMID": "39631418",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[Haematology and Oncology - A look back at 150 years].",
+ "Abstract": "The success story of haematology and oncology extends from Virchow's concept of \"cellular pathology\" to the possibilities of personalized cancer therapy, which molecular oncology offers today. This article highlights the beginnings and developments of chemotherapy, immunotherapy, as well as molecular oncology and psycho-oncology over the past 150 years.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Humans",
- "Single-Cell Analysis",
- "Lymphocytes, Tumor-Infiltrating",
+ "Hematology",
+ "Medical Oncology",
"Neoplasms",
- "RNA-Seq",
- "T-Lymphocytes, Regulatory",
- "Transcriptome",
- "Gene Expression Profiling",
- "Protein Interaction Maps",
- "Sequence Analysis, RNA",
- "Gene Regulatory Networks",
- "Gene Expression Regulation, Neoplastic",
- "Single-Cell Gene Expression Analysis"
- ]
+ "Drug Therapy",
+ "Immunotherapy",
+ "Biomarkers, Tumor",
+ "History, 19th Century",
+ "Humans",
+ "History, 20th Century",
+ "History, 21st Century",
+ "Precision Medicine"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
- "PMID": "39729462",
- "Title": "PloS one",
- "ArticleTitle": "Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis.",
- "Abstract": "MIRV has significant therapeutic effects in solid tumors, especially when combined with BEV. In platinum-tolerant tumors, the efficacy of MIRV is also considerable. Overall, MIRV is relatively safe in solid tumors, and adverse reactions are relatively rare and mild.",
+ "PMID": "39626634",
+ "Title": "Developmental cell",
+ "ArticleTitle": "From nuclear to extracellular PTEN: Multiple roles in tumor suppression and immune modulation.",
+ "Abstract": "In this issue of Developmental Cell, Zhang et\u00a0al. report that secreted PTEN reprograms immunosuppressive tumor-associated macrophages into an inflammatory phenotype by binding to PLXDC2, which enhances antitumor immunity. This Preview discusses diverse functions of PTEN in the nucleus, cytoplasm, and extracellular matrix, highlighting its multifaceted roles in cancer.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "PTEN Phosphohydrolase",
"Humans",
- "Maytansine",
- "Immunoconjugates",
- "Antibodies, Monoclonal, Humanized",
+ "Cell Nucleus",
"Neoplasms",
- "Female",
- "Folate Receptor 1",
- "Progression-Free Survival"
- ]
+ "Animals",
+ "Macrophages",
+ "Extracellular Matrix"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "4"
+ }
},
{
- "PMID": "39729341",
- "Title": "Biomacromolecules",
- "ArticleTitle": "Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors.",
- "Abstract": "The efficacy of tumor-targeted therapeutics, engineered to engage specific cellular receptors to promote accumulation and penetration, is strongly influenced by the carrier's affinity for its target and the valency of binding molecules incorporated into the carrier. Previous research has primarily focused on improving targeting by augmenting the number of binding proteins on the carrier, inadvertently raising avidity without isolating the individual effects of binding strength and valency. Herein, we precisely evaluate the impact of multivalency on tumor targeting with a recombinant approach to independently control valency, avidity, and size. Our findings reveal that constructs with equivalent binding strength exhibit comparable receptor engagement and tumor extravasation, regardless of valency. Moreover, excessive avidity adversely affected tumor accumulation and penetration, with the highest-avidity construct showing diminished exposure. These results indicate that overall binding strength, not valency, is the primary determinant of tumor targeting, providing valuable insights for designing effective macromolecular drug carriers.",
+ "PMID": "39625823",
+ "Title": "Clinical cancer research : an official journal of the American Association for Cancer Research",
+ "ArticleTitle": "RORing CAR T Cells in Solid and Hematologic Cancers: Same but Different.",
+ "Abstract": "A recent phase I clinical study tested anti-ROR1 chimeric antigen receptor (CAR) T cells in patients with chronic lymphocytic leukemia, non-small cell lung cancer, and triple-negative breast cancer. The product could be safely administered and had activity in chronic lymphocytic leukemia but less so in non-small cell lung cancer and triple-negative breast cancer. See related article by Jaeger-Ruckstuhl et al., p. 503.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Animals",
- "Mice",
+ "Immunotherapy, Adoptive",
+ "Receptors, Chimeric Antigen",
+ "Hematologic Neoplasms",
+ "T-Lymphocytes",
+ "Receptors, Antigen, T-Cell",
+ "Leukemia, Lymphocytic, Chronic, B-Cell",
"Neoplasms",
- "Drug Carriers",
- "Cell Line, Tumor",
- "Macromolecular Substances",
- "Protein Binding",
- "Drug Delivery Systems"
- ]
+ "Carcinoma, Non-Small-Cell Lung",
+ "Triple Negative Breast Neoplasms",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39729330",
- "Title": "Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association",
- "ArticleTitle": "A Scoping Review of Chemotherapy-induced Peripheral Neuropathy-Related Gait Abnormalities in Children With Cancer.",
- "Abstract": "Relevant research on the topic of CIPN-related gait abnormalities in children with cancer identifies knowledge gaps and the need for more studies on the effects of CIPN on children.",
+ "PMID": "39625239",
+ "Title": "Cancer research communications",
+ "ArticleTitle": "Efficacy of CBP/p300 Dual Inhibitors against Derepression of KREMEN2 in cBAF-Deficient Cancers.",
+ "Abstract": "In this study, we clarified that the cBAF subcomplex is deficient in the SWI/SNF complex, resulting in dependency on the CBP/p300 paralog pair. Simultaneous inhibitors of the CBP/p300 paralog pair show promise for cBAF-deficient lung cancer, as well as rare cancers such as malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Peripheral Nervous System Diseases",
- "Child",
- "Neoplasms",
- "Gait Disorders, Neurologic",
- "Antineoplastic Agents",
- "Gait",
- "Range of Motion, Articular",
- "Adolescent"
- ]
+ "p300-CBP Transcription Factors",
+ "Lung Neoplasms",
+ "Animals",
+ "E1A-Associated p300 Protein",
+ "Cell Line, Tumor",
+ "Mice",
+ "CREB-Binding Protein",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39729314",
- "Title": "JAMA network open",
- "ArticleTitle": "Radiologist Involvement in Radiation Oncology Peer Review: A Systematic Review and Meta-Analysis.",
- "Abstract": "In this systematic review and meta-analysis of radiation oncology PR of contoured targets, radiologist involvement in peer review was associated with a significant increase in the rate of total and clinically meaningful changes to the RT targets with no change in minor change rates. These results support the value of interdisciplinary collaboration with radiology during RT planning.",
+ "PMID": "39625051",
+ "Title": "The Cochrane database of systematic reviews",
+ "ArticleTitle": "Interventions for preventing oral mucositis in people receiving cancer treatment: photobiomodulation.",
+ "Abstract": "This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of photobiomodulation for the prevention of oral mucositis in people undergoing treatment for head and neck cancers, other solid cancers, and haematological cancers.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Radiation Oncology",
- "Radiologists",
- "Peer Review",
- "Peer Review, Health Care",
- "Neoplasms"
- ]
+ "Stomatitis",
+ "Neoplasms",
+ "Low-Level Light Therapy",
+ "Randomized Controlled Trials as Topic",
+ "Head and Neck Neoplasms",
+ "Review Literature as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39727835",
- "Title": "Biosensors",
- "ArticleTitle": "Application of Fluorescence- and Bioluminescence-Based Biosensors in Cancer Drug Discovery.",
- "Abstract": "Recent advances in drug discovery have established biosensors as indispensable tools, particularly valued for their precision, sensitivity, and real-time monitoring capabilities. The review begins with a brief overview of cancer drug discovery, underscoring the pivotal role of biosensors in advancing cancer research. Various types of biosensors employed in cancer drug discovery are then explored, with particular emphasis on fluorescence- and bioluminescence-based technologies such as FRET, TR-FRET, BRET, NanoBRET, and NanoBiT. These biosensors have enabled breakthrough discoveries, including the identification of Celastrol as a novel YAP-TEAD inhibitor through NanoBiT-based screening, and the development of TR-FRET assays that successfully identified Ro-31-8220 as a SMAD4R361H/SMAD3 interaction inducer. The integration of biosensors in high throughput screening and validation for cancer drug compounds is examined, highlighting successful applications such as the development of LATS biosensors that revealed VEGFR as an upstream regulator of the Hippo signaling pathway. Real-time monitoring of cellular responses through biosensors has yielded invaluable insights into cancer cell signaling pathways, as demonstrated by NanoBRET assays detecting RAF dimerization and HiBiT systems monitoring protein degradation dynamics. The review addresses challenges linked to biosensor applications, such as maintaining stability in complex tumor microenvironments and achieving consistent sensitivity in HTS applications. Emerging trends are discussed, including integrating artificial intelligence and advanced nanomaterials for enhanced biosensor performance. In conclusion, this review offers a comprehensive analysis of fluorescence- and bioluminescence-based biosensor applications in the dynamic cancer drug discovery field, presenting quantitative evidence of their impact and highlighting their potential to revolutionize targeted cancer treatments.",
+ "PMID": "39622255",
+ "Title": "British journal of haematology",
+ "ArticleTitle": "Advances and challenges in chimeric antigen receptor-natural killer cell immunotherapy for cancer.",
+ "Abstract": "Chimeric antigen receptor (CAR)-natural killer (NK)-cell therapy has emerged as a promising strategy in the treatment of haematological malignancies and solid cancers. Leveraging the innate immune properties of NK cells, CAR-NK-cell therapies offer potential advantages for cell therapy, including safety of use in the allogeneic setting and reduced risk of toxicity. This Nutshell provides an overview of the latest advancements in CAR-NK-cell therapy and the challenges that remain.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Biosensing Techniques",
"Humans",
- "Drug Discovery",
+ "Killer Cells, Natural",
+ "Receptors, Chimeric Antigen",
+ "Immunotherapy, Adoptive",
"Neoplasms",
- "Antineoplastic Agents",
- "Fluorescence",
- "Fluorescence Resonance Energy Transfer",
- "Signal Transduction",
- "Luminescent Measurements",
- "Pentacyclic Triterpenes"
- ]
+ "Hematologic Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39727719",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia.",
- "Abstract": "Chemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment continuity, and overall survival. The use of growth factors, including granulocyte colony-stimulating factors (GCSFs), erythropoietin-stimulating agents (ESAs), and thrombopoietin receptor agonists (TPO-RAs), has emerged as a promising strategy for managing CIC. However, the use of these growth factors must be approached with caution. This review provides an overview of the mechanisms, efficacy, and safety of growth factors in the management of CIC. Additionally, we discuss predictive markers for treatment response, potential risks, and highlight areas for future research.",
+ "PMID": "39618414",
+ "Title": "Future oncology (London, England)",
+ "ArticleTitle": "Decoding clinical trial jargon: helping people understand how safety and quality of life are assessed in cancer trials.",
+ "Abstract": "[Figure: see text].",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Neutropenia",
- "Antineoplastic Agents",
- "Anemia",
- "Thrombocytopenia",
+ "Quality of Life",
"Neoplasms",
- "Intercellular Signaling Peptides and Proteins",
- "Granulocyte Colony-Stimulating Factor",
- "Receptors, Thrombopoietin",
- "Cytopenia"
- ]
+ "Clinical Trials as Topic",
+ "Terminology as Topic",
+ "Comprehension",
+ "Patient Safety"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
- "PMID": "39727703",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Assessing Barriers to Cancer Screening and Early Detection in Older Adults in Saudi Arabia: A Mixed-Methods Approach to Oncology Nursing Practice Implications.",
- "Abstract": "The study underscores the multifaceted barriers faced by older adults in accessing cancer screening in Saudi Arabia. Tailored interventions that address logistical, psychological, and social factors are essential to enhance screening uptake and ensure equitable access to preventive services. These findings contribute to the ongoing discussions on public health strategies and underscore the necessity for community and healthcare provider engagement to improve cancer screening rates in this population.",
+ "PMID": "39607933",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "'Dark proteome' survey reveals thousands of new human genes.",
+ "Abstract": "Database confirms that overlooked segments of the genome code for a multitude of tiny proteins.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Saudi Arabia",
- "Early Detection of Cancer",
- "Female",
- "Male",
- "Aged",
- "Middle Aged",
+ "Genome, Human",
+ "Proteome",
+ "Micropeptides",
+ "Genes",
"Neoplasms",
- "Oncology Nursing",
- "Health Services Accessibility",
- "Aged, 80 and over"
- ]
+ "Sequence Analysis, DNA"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "28"
+ }
},
{
- "PMID": "39727701",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer.",
- "Abstract": "Frailty and myosteatosis are each prognostic of all-cause mortality (ACM) in patients with cancer. However, it is unclear whether myosteatosis adds value to frailty for predicting ACM. We assessed whether myosteatosis improves the predictive ability of frailty for ACM in older adults undergoing chemotherapy. This was a retrospective study of older adults (\u226565 years) initiating chemotherapy between June 2015 and June 2022. Frailty was assessed using a 24-item frailty index (FI). Myosteatosis was evaluated via computed tomography scans at the third lumbar vertebra (L3).. Multivariable Cox regression and Uno's c-statistic determined the predictive performance of the FI and myosteatosis. In total, 115 participants (mean age: 77.1 years) were included. Frailty alone (adjusted hazards ratio (aHR) = 1.68, 95% confidence intervals (CIs) = 1.03-2.72, ",
+ "PMID": "39601595",
+ "Title": "Cancer discovery",
+ "ArticleTitle": "Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations.",
+ "Abstract": "Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Aged",
- "Male",
- "Female",
- "Frailty",
"Neoplasms",
- "Retrospective Studies",
- "Aged, 80 and over",
- "Prognosis"
- ]
+ "Genomics",
+ "Antineoplastic Agents",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "27"
+ }
},
{
- "PMID": "39727700",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Peripheral Neuropathy Instruments for Individuals with Cancer: A COSMIN-Based Systematic Review of Measurement Properties.",
- "Abstract": "Although the literature on patient-reported outcomes (PROMs) continues to expand, challenges persist in selecting reliable and valid instruments for assessing peripheral neuropathy (PN) in patients with cancer. This systematic review aimed to identify all validated self-report PN scales and critically appraise their measurement properties. This review was conducted using the COSMIN methodology for PROMs and the PRISMA statement. Five databases were searched from inception to August 2024, identifying 46 eligible studies and 16 PROMs. Evidence quality ranged from \"very low\" to \"moderate\", with notable inconsistencies in the content and structural validity phases of most instruments. Instruments such as the Chemotherapy-induced peripheral neuropathy assessment tool and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity demonstrated moderate quality and potential utility in clinical practice, while others, including the Location-based assessment of sensory symptoms in cancer and the Measure of Ovarian Symptoms and Treatment, had insufficient evidence to support their use. Importantly, all PROMs focused on chemotherapy-induced peripheral neuropathy, highlighting a significant gap in instruments addressing other PN causes, such as radiotherapy or tumor-related nerve damage. Further research should prioritize developing and validating instruments for distinct cancer populations, ensuring robust psychometric properties and clinical applicability.",
+ "PMID": "39571039",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "Macrophage modulation of tumor immunity.",
+ "Abstract": "Macrophages deliver polarizing messages to promote immune suppression in tumors.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Animals",
"Humans",
- "Peripheral Nervous System Diseases",
+ "Mice",
"Neoplasms",
- "Patient Reported Outcome Measures",
- "Psychometrics"
- ]
+ "Tumor Microenvironment",
+ "Tumor-Associated Macrophages",
+ "Immune Tolerance"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39727690",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Features of the Nurse-Patient Relationship: Insights from a Qualitative Review Using Artificial Intelligence Interpretation.",
- "Abstract": "The GAI-enabled exploration provided valuable insights into several dimensions of care, emphasizing the importance of spiritual sensitivity, empathic communication, and ongoing professional growth. As technology and human care converge, integrating artistry into the nurse-patient relationship could enhance patient experiences, improve outcomes, and enrich the oncology nursing practice.",
+ "PMID": "39571009",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "Ferroptosis-disease perils and therapeutic promise.",
+ "Abstract": "Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Animals",
"Humans",
- "Artificial Intelligence",
- "Empathy",
+ "Ferroptosis",
+ "Iron",
+ "Neurodegenerative Diseases",
"Neoplasms",
- "Nurse-Patient Relations",
- "Oncology Nursing",
- "Qualitative Research"
- ]
+ "Hemochromatosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39727688",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Symptom Burden and Dietary Changes Among Older Adults with Cancer: A Cross-Sectional Study.",
- "Abstract": "Taken together, older cancer inpatients are frail and have a high risk of malnutrition. Screening should not only consider energy intake but also symptom burden and dietary changes to optimize supportive care.",
+ "PMID": "39541468",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "The counterattack.",
+ "Abstract": "An immune cell treatment that fights cancer is now taking aim at autoimmune disease.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Aged",
- "Neoplasms",
- "Cross-Sectional Studies",
- "Male",
- "Female",
- "Malnutrition",
- "Aged, 80 and over",
- "Nutritional Status",
- "Surveys and Questionnaires",
- "Nutrition Assessment",
- "Diet",
- "Symptom Burden"
- ]
+ "Autoimmune Diseases",
+ "Immunotherapy, Adoptive",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "14"
+ }
},
{
- "PMID": "39727686",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Potential Benefits from Physical Exercise in Advanced Cancer Patients Undergoing Systemic Therapy? A Narrative Review of the Randomized Clinical Trials.",
- "Abstract": "We reviewed the data of 35 RCTs on the use of physical exercise in cancer patients, distinguishing well-nourished from malnourished patients. The conclusions of our study are the following: No major difference between well-nourished and malnourished patients as regards compliance/adherence with physical exercise and outcomes. Compliance with physical exercise was reported in about 70% of the studies. Compared with a control group receiving the usual care, in patients who practiced physical exercise, a benefit in some parameters of physical function and quality of life and lean body mass (LBM) was reported in 61%, 47%, and 12%, respectively, of the studies in non-malnourished patients, and in 50%, 100%, and 36%, respectively, of the studies in malnourished patients. The benefit in LBM was more frequently reported in weight-losing patients. There was no strict association among the results of different outcomes (muscle function vs. quality of life vs. LBM). There are still some ill-defined issues, including the optimal physical regimen (with some authors favoring high-intensity interval training and resistance) and the place of exercising (patients usually preferring home exercises, which, however, have been proved less efficacious).",
+ "PMID": "39535567",
+ "Title": "Cancer immunology, immunotherapy : CII",
+ "ArticleTitle": "\"Tumor immunology meets oncology\" (TIMO), 18 April-20 April 2024, in Brandenburg an der Havel, Germany.",
+ "Abstract": "The TIMO meeting XVIII 2024 covered both basic and translational tumor immunological topics, which were presented by national and international scientists and clinicians.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Exercise",
- "Exercise Therapy",
"Neoplasms",
- "Quality of Life",
- "Randomized Controlled Trials as Topic"
- ]
+ "Germany",
+ "Medical Oncology",
+ "Immunotherapy",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39727684",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Methadone in Cancer-Related Neuropathic Pain: A Narrative Review.",
- "Abstract": {
- "b": "Conclusions",
- "i": "cancer-related opioid treatment"
- },
+ "PMID": "39499776",
+ "Title": "Science signaling",
+ "ArticleTitle": "The cancer risk of repeat RNAs.",
+ "Abstract": "Repeat RNAs reprogram tumor cells and cancer-associated fibroblasts in pancreatic cancer.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Methadone",
- "Neuralgia",
- "Cancer Pain",
- "Analgesics, Opioid",
- "Neoplasms",
- "Quality of Life"
- ]
+ "Pancreatic Neoplasms",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "5"
+ }
},
{
- "PMID": "39727683",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Fertility-Related Concerns in Long-Term Survivors of Childhood Cancer: A Canadian Cohort Study.",
- "Abstract": "Survivors of childhood cancer face reduced fertility, which can be a significant cause for concern. Our study aimed to assess the prevalence of fertility-related concerns and identify associated factors. Self-report data were collected with the Long-Term Survivor Questionnaire at the Alberta Children's Hospital's Long-Term Survivor Clinic (LTSC) between January 2021 and September 2023. Eligible participants were diagnosed before the age of 21 years, \u22652 years off therapy, and \u226513 years old. We analyzed fertility-related concerns cross-sectionally for the whole sample and longitudinally for a subsample of participants that completed three questionnaires. We included ",
+ "PMID": "39496083",
+ "Title": "Health affairs (Project Hope)",
+ "ArticleTitle": "Morbidity And Mortality: Delays In My Patient's Cancer Care.",
+ "Abstract": "A clinician analyzes what caused months-long delays in the care of a patient diagnosed with cancer.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Humans",
"Female",
- "Cancer Survivors",
+ "Humans",
"Male",
- "Adult",
- "Adolescent",
"Neoplasms",
- "Young Adult",
- "Fertility",
- "Cohort Studies",
- "Surveys and Questionnaires",
- "Canada",
- "Cross-Sectional Studies"
- ]
+ "Time-to-Treatment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "4"
+ }
},
{
- "PMID": "39727682",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Fear of Cancer Recurrence and Fear of Cancer Progression, Digital Resource Engagement and Health Literacy: A Review.",
- "Abstract": "Cancer care is evolving, and digital resources are being introduced to support cancer patients throughout the cancer journey. Logistical concerns, such as health literacy and the emotional experience of cancer, need to be considered. Fear of cancer recurrence (FCR) and fear of cancer progression (FOP) are relevant emotional constructs that should be investigated. This scoping review explored two main objectives: first, the link between FCR/FOP and engagement with digital resources, and second, the link between FCR/FOP and health literacy. A database search was conducted separately for each objective. Relevant papers were identified, data were extracted, and a quality assessment was conducted. Objective 1 identified two relevant papers that suggested that higher levels of FCR were correlated with lower levels of engagement with digital resources. Objective 2 identified eight relevant papers that indicated that higher FCR/FOP is correlated with lower health literacy. However, one paper with a greater sample size and a more representative sample reported no significant relationship. There may be important relationships between the constructs of FCR/FOP, resource engagement, and health literacy and relationships may differ across cancer type and sex. However, research is limited. No studies examined the relationship between FOP and engagement or FCR/FOP and digital health literacy, and the number of studies identified was too limited to come to a firm conclusion. Further research is needed to understand the significance and relevance of these relationships.",
+ "PMID": "39485858",
+ "Title": "Science immunology",
+ "ArticleTitle": "TAM-ing the beast with IL-34 blockade.",
+ "Abstract": "mutation triggers IL-34 secretion by cancer stem cells, reprogramming macrophages to suppress T cells and promote tumor immune escape.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Health Literacy",
- "Fear",
+ "Interleukins",
+ "Animals",
"Neoplasms",
- "Neoplasm Recurrence, Local",
- "Disease Progression"
- ]
+ "Macrophages",
+ "Tumor Suppressor Protein p53",
+ "Neoplastic Stem Cells",
+ "Tumor Escape",
+ "Mutation",
+ "Mice"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "1"
+ }
},
{
- "PMID": "39727182",
- "Title": "Expert opinion on therapeutic patents",
- "ArticleTitle": "Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003-present).",
- "Abstract": "ATM kinase is a promising target for cancer therapy. Small-molecule ATM kinase inhibitors hold significant potential in cancer treatment by enhancing the efficacy of existing DNA-damaging therapies. Patent analysis revealed that the majority of these compounds contain imidazo[4,5-c]quinolinone scaffold or its bioisosteric variations which are optimal in terms of good ATM inhibitory activity and selectivity over closely related enzymes. Clinical trials explore combinations with RT or DNA-targeted compounds like PARP inhibitors, which induce DSBs. The medicinal chemistry field anticipates that these therapeutic options will soon be available on the pharmaceutical market.",
+ "PMID": "39482077",
+ "Title": "Zhonghua nei ke za zhi",
+ "ArticleTitle": "[Advances in targeting the interleukin-6 signalling pathway in cancer therapy].",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Patents as Topic",
- "Ataxia Telangiectasia Mutated Proteins",
+ "Signal Transduction",
"Neoplasms",
- "Antineoplastic Agents",
- "Animals",
- "Protein Kinase Inhibitors",
- "Drug Development",
- "Molecular Targeted Therapy",
- "DNA Breaks, Double-Stranded"
- ]
+ "Interleukin-6",
+ "Inflammation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "1"
+ }
},
{
- "PMID": "39726750",
- "Title": "PeerJ",
- "ArticleTitle": "Malignant solid tumor-related spontaneous intracerebral hemorrhage: a propensity score matching study.",
- "Abstract": "Decreased HGB levels, elevated LYCs, and a higher NLR were identified as independent risk factors for sICH in patients with active solid malignancies. These markers could assist clinicians in stratifying high-risk patients, facilitating closer monitoring and informing targeted preventive strategies to mitigate the incidence of sICH in this at-risk population.",
+ "PMID": "39482076",
+ "Title": "Zhonghua nei ke za zhi",
+ "ArticleTitle": "[Standardized diagnosis and treatment of immune checkpoint inhibitor-induced thyroid dysfunction].",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Cerebral Hemorrhage",
- "Retrospective Studies",
- "Middle Aged",
- "Propensity Score",
- "Risk Factors",
+ "Immune Checkpoint Inhibitors",
+ "Thyroid Diseases",
"Neoplasms",
- "Aged",
- "Prognosis",
- "Neutrophils",
- "Hemoglobins",
- "China",
- "ROC Curve"
- ]
+ "Thyroid Gland"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "1"
+ }
},
{
- "PMID": "39726590",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "The potential of cellular homing behavior in tumor immunotherapy: from basic discoveries to clinical applications of immune, mesenchymal stem, and cancer cell homing.",
- "Abstract": "The efficacy of immunotherapy, a pivotal approach in the arsenal of cancer treatment strategies, is contingent on the capacity of effector cells to localize at the tumor site. The navigational capacity of these cells is intricately linked to the homing behaviors of specific cell types. Recent studies have focused on leveraging immune cells and mesenchymal stem cells (MSCs) homing for targeted tumor therapy and incorporating cancer cell homing properties into anti-tumor strategies. However, research and development of immunotherapy based on cancer cell homing remain in their preliminary stages. Enhancing the homing efficiency of effector cells is essential; therefore, understanding the underlying mechanisms and addressing immune resistance within the tumor microenvironment and challenges associated with ",
+ "PMID": "39482045",
+ "Title": "Zhonghua bing li xue za zhi = Chinese journal of pathology",
+ "ArticleTitle": "[Consensus on the molecular residual disease testing in solid tumor].",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Animals",
+ "Neoplasm, Residual",
"Humans",
- "Cell Movement",
- "Immunotherapy",
- "Mesenchymal Stem Cell Transplantation",
- "Mesenchymal Stem Cells",
"Neoplasms",
- "Tumor Microenvironment"
- ]
+ "Consensus",
+ "Prognosis",
+ "Neoplasm Recurrence, Local",
+ "China"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "1"
+ }
},
{
- "PMID": "39726589",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Bibliometric analysis and visualization of the research on the relationship between RNA methylation and immune cell infiltration in tumors.",
- "Abstract": "Future investigative efforts at the juncture of RNA methylation and tumor immune cells are anticipated to concentrate on domains including m5C, n7-methylguanosine, cuproptosis, prognosis assessment, immunotherapeutic strategies, and the tumor microenvironment.",
+ "PMID": "39454117",
+ "Title": "Journal of clinical oncology : official journal of the American Society of Clinical Oncology",
+ "ArticleTitle": "Redefining Available Therapy in Oncology Accelerated Approval Decisions.",
+ "Abstract": "When weighing rapid approval for follow-on drugs, should @FDAOncology recognize the drugs that came before?",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
+ "Drug Approval",
+ "United States",
+ "United States Food and Drug Administration",
"Neoplasms",
- "Bibliometrics",
- "Methylation",
- "Tumor Microenvironment",
- "RNA",
- "Lymphocytes, Tumor-Infiltrating",
- "Animals",
- "RNA Methylation"
- ]
+ "Antineoplastic Agents",
+ "Medical Oncology"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "25"
+ }
},
{
- "PMID": "39726379",
- "Title": "Journal of medicinal chemistry",
- "ArticleTitle": "A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment.",
- "Abstract": "Lipid metabolism disorder is the cause of one of the most significant metabolic changes in tumors. In the process of tumor occurrence and development, tumor cells choose a continuous metabolic adaptation to accommodate the changing environment to the maximum extent possible. In a variety of tumors, the uptake, production, and storage of lipids are generally upregulated. Tumor cells take advantage of lipid metabolism to access basic energy, biofilm components, and signal molecules of the tumor microenvironment required for proliferation, survival, invasion, and metastasis. This Perspective briefly uncovers the main metabolic processes and key factors involved in lipid metabolism reprogramming, mainly related to lipid uptake, ",
+ "PMID": "39446947",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "Impact of CRISPR in cancer drug discovery.",
+ "Abstract": "Precision gene editing enables massively parallel identification of cancer-promoting genes.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Animals",
"Humans",
- "Tumor Microenvironment",
"Antineoplastic Agents",
- "Lipid Metabolism",
- "Neoplasms",
- "Animals"
- ]
+ "CRISPR-Cas Systems",
+ "Drug Discovery",
+ "Gene Editing",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "25"
+ }
},
{
- "PMID": "39726369",
- "Title": "Nanomedicine (London, England)",
- "ArticleTitle": "Nanozyme-mediated glutathione depletion for enhanced ROS-based cancer therapies: a comprehensive review.",
- "Abstract": "Nanozymes can improve reactive oxygen species (ROS)-based cancer therapies by targeting cancer cells' antioxidant defense mechanisms, particularly glutathione (GSH) depletion, to overcome ROS-resistant cancer cells. Nanozymes, innovative enzyme-mimetic nanomaterials, can generate ROS, alter the tumor microenvironment (TME), and synergize with photodynamic therapy (PDT), chemodynamic therapy (CDT), radiotherapy, and immunotherapy. This review shows how nanozymes catalyze ROS generation, selectively deplete GSH, and target cancer elimination, offering clear advantages over standard therapies. Nanozymes selectively target cancer cells' antioxidant defenses to improve PDT, CDT, and radiation therapies. To maximize nanozyme-based cancer treatment efficacy, biodistribution, biocompatibility, and tumor heterogeneity must be assessed. To improve cancer treatment, multifunctional, stimuli-responsive nanozymes and synergistic combination drugs should be developed.",
+ "PMID": "39418388",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "Reprogramming tumor cells to fight cancer.",
+ "Abstract": "Cancer cells reprogrammed into dendritic cells in vivo promote antitumor immunity.",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Dendritic Cells",
"Humans",
+ "Cellular Reprogramming",
"Neoplasms",
- "Reactive Oxygen Species",
- "Glutathione",
- "Photochemotherapy",
"Animals",
- "Tumor Microenvironment",
- "Nanostructures",
- "Antineoplastic Agents",
- "Photosensitizing Agents",
- "Antioxidants",
- "Immunotherapy"
- ]
+ "Mice"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "18"
+ }
},
{
- "PMID": "39726308",
- "Title": "Discovery medicine",
- "ArticleTitle": "Uncommon but Significant: Onset, Characteristics and Management of Vasculitis and Connective Tissue Diseases Induced by Immunomodulators during Cancer Treatment.",
- "Abstract": "The introduction of immunomodulators as adjuvant therapies in cancer treatment has represented a significant advancement in oncology, improving therapeutic response and patient survival. Emerging targets and molecules could provide new therapeutic opportunities for cancer patients. However, these agents can induce immunological side effects, including vasculitis and connective tissue diseases, which, while uncommon, present significant clinical challenges. This review analyzes the prevalence, clinical characteristics, therapeutic strategies, and management difficulties of vasculitis and connective tissue disorders triggered by immunomodulators in the context of cancer treatment. Although rare, these conditions significantly impact patients, demanding thorough management. Common rheumatological immune-related adverse events include inflammatory arthritis, Sjogren's disease, systemic lupus erythematosus, and systemic sclerosis, all of which require prompt recognition and appropriate intervention. Treatment frequently includes corticosteroids and immunosuppressive drugs, with new alternatives currently accessible. Efficient coordination between oncologists and rheumatologists enhances patient outcomes, highlighting the necessity for organized multidisciplinary strategies. Future research initiatives emphasize the identification of biomarkers for early diagnosis and the development of preventive methods to reduce immune-related adverse events in cancer therapy.",
+ "PMID": "39412901",
+ "Title": "Journal of cancer research and therapeutics",
+ "ArticleTitle": "Exploring the challenges of three-dimensional printing technology in brachytherapy.",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
+ "Brachytherapy",
"Humans",
+ "Printing, Three-Dimensional",
"Neoplasms",
- "Connective Tissue Diseases",
- "Vasculitis",
- "Immunologic Factors",
- "Immunomodulating Agents"
- ]
+ "Radiotherapy Planning, Computer-Assisted"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39726258",
- "Title": "Journal of medical virology",
- "ArticleTitle": "Modified Vaccinia Virus Ankara Selectively Targets Human Cancer Cells With Low Expression of the Zinc-Finger Antiviral Protein.",
- "Abstract": "Oncolytic viruses are emerging as promising cancer therapeutic agents, with several poxviruses, including vaccinia virus (VACV) and myxoma virus, showing significant potential in preclinical and clinical trials. Modified vaccinia virus Ankara (MVA), a laboratory-derived VACV strain approved by the FDA for mpox and smallpox vaccination, has been shown to be incapable of replicating in human cells unless zinc finger antiviral protein (ZAP) is repressed. Notably, ZAP deficiency is prevalent in various cancer types. We hypothesized that MVA could selectively target and replicate in ZAP-deficient cancer cells. Our study examined MVA's replication across multiple cancer cell lines with varying ZAP expression levels, revealing that MVA replicates more efficiently in cells with lower ZAP expression. Additionally, we assessed MVA's oncolytic potential using a xenograft mouse model, where cancer cells were transplanted into immunodeficient mice. The data demonstrated that MVA significantly reduced tumors with lower ZAP expression without causing morbidity in nude mice. These findings suggest that MVA holds promise for further development as a targeted therapy for ZAP-deficient cancers.",
+ "PMID": "39412542",
+ "Title": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
+ "ArticleTitle": "Death anxiety-we have more to go.",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
- "Vaccinia virus",
"Humans",
- "Animals",
- "Cell Line, Tumor",
- "Mice",
- "Mice, Nude",
- "Virus Replication",
- "Oncolytic Viruses",
- "Oncolytic Virotherapy",
- "RNA-Binding Proteins",
- "Neoplasms",
- "Xenograft Model Antitumor Assays",
- "Female"
- ]
+ "Anxiety",
+ "Attitude to Death",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39726235",
- "Title": "Clinical and translational science",
- "ArticleTitle": "Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors.",
- "Abstract": "Iruplinalkib (WX-0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first-line therapy for ALK-positive non-small-cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK-positive NSCLC that has progressed following crizotinib therapy. Pharmacokinetics (PK) data of iruplinalkib have been collected in healthy subjects and patient populations in several studies. We developed a population PK (PopPK) model for describing iruplinalkib plasma concentrations and for evaluating whether dose adjustments are necessary based on demographic factors or disease characteristics. Plasma concentration-time data were collected from 392 participants (16 healthy volunteers and 372 patients with solid tumors) who received single or multiple doses of iruplinalkib in four trials. Data were analyzed using non-linear mixed-effects modeling. Iruplinalkib plasma concentrations were best described by a two-compartment model with first-order absorption and first-order elimination. Baseline body weight, time-varying albumin, time-varying creatinine clearance, and time-varying lactate dehydrogenase were significant covariates of apparent clearance from the central compartment (CL/F) while baseline body weight was a significant covariate of apparent volume of the central compartment (V1/F). Given the small or modest effect of all statistically significant covariates on iruplinalkib exposure at steady-state, no covariate was expected to have clinically meaningful effects on iruplinalkib exposure. Furthermore, iruplinalkib absorption was delayed 0.472\u2009h after meal, and K",
+ "PMID": "39408692",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Special Issue \"Research Progress of Bioimaging Materials\".",
+ "Abstract": "In the context of increasingly diverse diseases, early diagnosis and prevention, particularly in cancer control, have become more important than ever [...].",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
+ "Animals",
"Neoplasms",
- "Aged",
- "Healthy Volunteers",
- "Protein Kinase Inhibitors",
- "Young Adult",
- "Models, Biological",
- "Aged, 80 and over",
- "Carcinoma, Non-Small-Cell Lung"
- ]
+ "Diagnostic Imaging",
+ "Molecular Imaging"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39726139",
- "Title": "JMIR cancer",
- "ArticleTitle": "Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study.",
- "Abstract": "The analysis of objective pre- and postdiagnostic step count data provided fundamental information crucial for understanding changes in PA among patients with cancer. While cancer diagnosis and treatment reduced PA, the decline may have already started before diagnosis. The study findings may help tailor exercise recommendations based on lifelog data for patients with cancer in the future.",
+ "PMID": "39406750",
+ "Title": "Signal transduction and targeted therapy",
+ "ArticleTitle": "Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities.",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
"Neoplasms",
- "Retrospective Studies",
- "Female",
- "Male",
- "Japan",
- "Middle Aged",
- "Exercise",
- "Smartphone",
- "Databases, Factual",
- "Aged",
- "Adult",
- "Cohort Studies",
- "East Asian People"
- ]
+ "Proteogenomics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39726004",
- "Title": "BMC health services research",
- "ArticleTitle": "Barriers to quality cancer care: a qualitative exploration of oncology case managers' experiences in facilitating guideline implementation in Taiwan.",
- "Abstract": "Guidelines are vital tools to ensure the quality of cancer care. However, based on the experiences of OCMs, shortcomings in institutional design, hierarchical organizational culture, misconceptions about the role of OCMs, and a lack of support from management have been identified as key obstacles in the implementation process. Suggestions of ways to address these challenges and promote successful guideline implementation are proposed.",
+ "PMID": "39406424",
+ "Title": "Canadian family physician Medecin de famille canadien",
+ "ArticleTitle": "Cardiotoxicity of cancer treatment.",
+ "Abstract": "",
"Predictions": [
"Cancer"
],
"MeshTerms": [
"Humans",
- "Taiwan",
- "Qualitative Research",
- "Guideline Adherence",
- "Practice Guidelines as Topic",
- "Neoplasms",
- "Quality of Health Care",
- "Case Managers",
- "Medical Oncology",
- "Interviews as Topic",
- "Male"
- ]
+ "Cardiotoxicity",
+ "Antineoplastic Agents",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/cardiovascular_diseases.json b/testModel/dataset/cardiovascular_diseases.json
index 32ee41684..2fae6eeab 100644
--- a/testModel/dataset/cardiovascular_diseases.json
+++ b/testModel/dataset/cardiovascular_diseases.json
@@ -24,33 +24,12 @@
"Mining",
"Risk Factors",
"Occupational Diseases"
- ]
- },
- {
- "PMID": "39738021",
- "Title": "Nature communications",
- "ArticleTitle": "Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.",
- "Abstract": "Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China. An integrated exposure-response model was used to estimate the association between OP and EPFRs and hospitalization during SDS. EPFRs were strongly associated with circulatory (3.05%; 95% confidence interval [CI]: 1.01%, 4.08%) and respiratory (2.02%; 95% CI: 1.01%, 4.08%) diseases with each increase of 10",
- "Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Dust",
- "Humans",
- "Hospitalization",
- "Free Radicals",
- "Air Pollutants",
- "Oxidative Stress",
- "Particulate Matter",
- "China",
- "Environmental Exposure",
- "Beijing",
- "Sand",
- "Respiratory Tract Diseases",
- "Oxidation-Reduction",
- "Cardiovascular Diseases"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39738016",
@@ -79,13 +58,18 @@
"Glutamates",
"Endothelial Cells",
"Middle Aged"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736858",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018.",
- "Abstract": "Adherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.",
+ "Abstract": "Oxidative stress has an important role in type 2 diabetes (T2D). Oxidative balance score (OBS) is an emerging assessment of dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with cardiovascular disease (CVD) and all-cause and CVD mortality in the T2D population through NHANES 1999-2018.OBS integrated 16 dietary components and 4 lifestyle components. T2D was diagnosed according to the American Diabetes Association criteria. Multivariate logistic regression and multivariate Cox proportional hazards regression analyses were used to explore the association of OBS with CVD and mortality in T2D, respectively.3801 adult T2D participants were included. In fully adjusted models, OBS, dietary OBS, and lifestyle OBS were all negatively associated with the prevalence of CVD (odds ratios of 0.98, 0.98, and 0.85, respectively). Higher OBS and lifestyle OBS (p for trend 0.016 and <0.001, respectively) rather than dietary OBS (p for trend = 0.06) were associated with significantly lower odds of CVD. Higher OBS, dietary OBS, and lifestyle OBS were all negatively associated with all-cause mortality (hazard ratios [HR] of 0.98, 0.98, and 0.92, respectively; p for trend of 0.002, 0.009, and 0.035, respectively). Higher OBS and dietary OBS were negatively associated with CVD mortality (HR 0.96 and 0.95, respectively; p for trend both <0.001), whereas lifestyle OBS was not. Restricted cubic spline analysis suggested that most associations were linear. Stratified analyses showed that these associations were influenced by some demographic variables and disease status.Adherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.",
"Predictions": [
"Cardiovascular diseases",
"Diabetes type 2"
@@ -107,13 +91,18 @@
"Risk Factors",
"Follow-Up Studies",
"Prevalence"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736721",
"Title": "BMC medicine",
"ArticleTitle": "Changes in sarcopenia and incident cardiovascular disease in prospective cohorts.",
- "Abstract": "Changes in sarcopenia status are associated with varying risks of new-onset CVD. Progression in sarcopenia status increases the risk, while recovery from sarcopenia reduces the risk of developing cardiovascular disease.",
+ "Abstract": "Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these studies primarily focused on sarcopenia status at baseline, without considering changes in sarcopenia status during follow-up. The aim of this study is to investigate the association between changes in sarcopenia status and the incidence of new-onset cardiovascular disease.This study utilized prospective cohort data from the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia status was assessed using the 2019 Asian Working Group for Sarcopenia (AWGS) algorithm and categorized as non-sarcopenia, possible sarcopenia, or sarcopenia. Changes in sarcopenia status were evaluated based on assessments at baseline and at the second follow-up survey 2\u00a0years later. CVD was identified through self-reported physician diagnoses of heart disease, including angina, myocardial infarction, congestive heart failure, and other heart problems, or stroke. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounding factors.Based on the inclusion and exclusion criteria, a total of 7499 CHARLS participants were included in the analysis, with 50.8% being female and an average age of 58.5\u00a0years. Compared to participants with stable non-sarcopenia status, those who progressed from non-sarcopenia to possible sarcopenia or sarcopenia exhibited a significantly increased risk of new-onset CVD (HR 1.30, 95% CI 1.06-1.59). Conversely, participants who recovered from sarcopenia to non-sarcopenia or possible sarcopenia had a significantly reduced risk of new-onset CVD compared to those with stable sarcopenia status (HR 0.61, 95% CI 0.37-0.99). Among participants with baseline possible sarcopenia, those who recovered to non-sarcopenia had a significantly lower risk of new-onset CVD compared to those with stable possible sarcopenia status (HR 0.67, 95% CI 0.52-0.86).Changes in sarcopenia status are associated with varying risks of new-onset CVD. Progression in sarcopenia status increases the risk, while recovery from sarcopenia reduces the risk of developing cardiovascular disease.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -131,40 +120,18 @@
"Longitudinal Studies",
"Risk Factors",
"Proportional Hazards Models"
- ]
- },
- {
- "PMID": "39736689",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
- "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
- "Predictions": [
- "Diabetes",
- "Cancer",
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Humans",
- "Cardiovascular Diseases",
- "Neoplasms",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
- "Longitudinal Studies",
- "Aged",
- "Proportional Hazards Models",
- "Diabetes Mellitus",
- "Risk Factors",
- "Cardiometabolic Risk Factors",
- "Cohort Studies"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736563",
"Title": "BMC cardiovascular disorders",
"ArticleTitle": "The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study.",
- "Abstract": "The hs-CRP/HDL-C ratio is a crucial predictor of long-term mortality in the general population, independent of potential confounding factors.",
+ "Abstract": "The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio, a composite marker of low-grade inflammation and lipid metabolism, is reportedly associated with the occurrence of new cardiovascular diseases (CVDs) in certain people. However, the predictive value of the hs-CRP/HDL-C ratio for long-term mortality in the general population remains unclear.This retrospective cohort study included data from 9,492 adults obtained from the National Health and Nutrition Examination Survey (NHANES) (2015-2018) in the United States. Multivariate Cox regression, two-piecewise linear regression, restricted cubic spline (RCS) models and subgroup analysis by age, sex, smoking status and drinking status were applied to evaluate the associations of the hs-CRP/HDL-C ratio with long-term all-cause and cardiovascular mortality.The overall median age of the cohort was 47.0 years (interquartile range (IQR) 32.0-62.0), and 4,585 (48.30%) patients were male. During a median follow-up period of 37.0 months, 239 (2.52%) all-cause deaths occurred, 59 (0.62%) of which were attributed to cardiovascular events. Participants with all-cause and cardiovascular mortality presented a higher hs-CRP/HDL-C ratio than did those without events [0.56 (0.24-1.38) vs. 0.37 (0.14-0.94) and 0.60 (0.23-1.60) vs. 0.37 (0.14-0.95), P\u2009<\u20090.001 and P\u2009=\u20090.002]. According to multivariate Cox regression models, the hs-CRP/HDL-C ratio was found to be an independent risk factor for both long-term all-cause mortality [hazard ratio (HR)\u2009=\u20091.09, 95% confidence interval (CI): 1.05-1.13] and cardiovascular mortality (HR\u2009=\u20091.11, 95% CI: 1.05-1.19). A two-piecewise linear regression model indicated that the risk of all-cause mortality increased more prominently when the hs-CRP/HDL-C ratio was less than 1.21. In addition, a significant interaction effect with smoking status was discovered (P\u2009=\u20090.006), indicating that the association of the hs-CRP/HDL-C ratio with all-cause mortality was stronger in nonsmokers. The RCS curve revealed a positive linear association of the hs-CRP/HDL-C ratio with long-term mortality after adjustment for potential confounders.The hs-CRP/HDL-C ratio is a crucial predictor of long-term mortality in the general population, independent of potential confounding factors.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -188,13 +155,18 @@
"United States",
"Risk Factors",
"Aged"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736401",
"Title": "Journal of affective disorders",
"ArticleTitle": "Psychosocial and cognitive determinants of 10-year depressive symptom trajectories in patients with cardiovascular disease: The SMART-Medea Study.",
- "Abstract": "Our findings emphasize that a wide range of psychosocial factors are associated with mild as well as severe trajectories of depressive symptoms in patients with manifest CVD. Focusing on psychosocial factors could improve one's prognosis of depressive symptomology.",
+ "Abstract": "Middle-aged and older adults presenting clinically relevant depressive symptoms are often undiagnosed. Understanding the determinants of late-life depressive symptoms could improve prognosis. Further, individuals with manifest cardiovascular disease (CVD) are at an increased risk of depression. This study investigated if psychosocial and cognitive factors are associated with depressive symptom trajectories in individuals with CVD.Longitudinal data from the SMART-Medea study of 752 participants (median age 62\u00a0years, women 18\u00a0%) with a history of CVD was used. Psychosocial determinants (i.e., history of depression, anxiety, neuroticism, locus of control, adverse childhood events, recent adverse events, social support, and somatization) and cognition (i.e., memory functioning, working memory, executive functioning, and processing speed) were assessed via multinomial logistic regressions with depressive symptoms trajectories as outcome (i.e., \"never depressed\" (reference), \"energy/sleep difficulties\", \"mild depressive symptoms\" and \"fluctuating severe depression\"). Depressive symptom trajectories were based off of longitudinal PHQ-9 scores and created using latent class analysis. Analyses were adjusted for age, sex/gender, and education.All psychosocial factors were associated with depressive symptom trajectories, except for social support, with increasing associations from the \"energy/sleep difficulties\" to the \"fluctuating severe depression\". For cognitive factors, only memory functioning was associated with decreased odds of \"fluctuating severe depression\" (OR\u00a0=\u00a00.63, 95\u00a0% CI\u00a0=\u00a00.47-0.85).The study population consisted of mostly white male participants with CVD; thus, the generalizability to other populations is low.Our findings emphasize that a wide range of psychosocial factors are associated with mild as well as severe trajectories of depressive symptoms in patients with manifest CVD. Focusing on psychosocial factors could improve one's prognosis of depressive symptomology.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -211,7 +183,12 @@
"Cognition",
"Risk Factors",
"Anxiety"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736180",
@@ -227,7 +204,12 @@
"Food, Fortified",
"Fatty Acids, Omega-3",
"Animals"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736025",
@@ -247,13 +229,18 @@
"Thyroxine",
"Cardiovascular Diseases",
"Echocardiography"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735642",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease.",
- "Abstract": "Our research found that longer LTL improved survival in patients with ALD and decreased CVD and cancer-related mortality. LTL decreased all-cause mortality especially for patients older than 65 years or men. LTL might be a useful biomarker for prognosis among patients with ALD. More prospective studies are needed to assess the relevance between LTL and mortality and explore the underlying mechanisms between them.",
+ "Abstract": "It is necessary to find latent indicators to predict the survival of alcohol-associated liver disease (ALD) patients. Leukocyte telomere length (LTL) was regarded as an indicator of prognosis in several diseases. However, the relationships between LTL and survival as well as cause-specific mortality in ALD patients were still unknown.This study aimed at exploring the underlying link between LTL and the risk of mortality in patients with ALD.The LTL and survival data were gathered from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The connection between LTL and mortality was assessed by Cox regression models and stratified analyses. The non-linear relationship was explored by restricted cubic spline (RCS) analysis. Sensitivity analyses were used to evaluate the robustness of our findings.LTL was a negative factor for all-cause mortality (all -value < 0.05). The risk of cardiovascular disease (CVD)-related death was decreased in Q3 ( < 0.001) and Q4 levels of LTL ( < 0.001) compared with the Q1 group. Shorter LTL resulted in higher cancer-caused mortality ( = 0.03) in the Q2 group. Longer LTL improved survival especially for elder patients ( for trend < 0.001) or men ( for trend = 0.001). Moreover, there were L-shaped correlations between LTL and all-cause mortality ( for non-linearity = 0.02), as well as cancer-related mortality ( for non-linearity < 0.001). Four sensitivity analyses proved the robustness of our findings.Our research found that longer LTL improved survival in patients with ALD and decreased CVD and cancer-related mortality. LTL decreased all-cause mortality especially for patients older than 65 years or men. LTL might be a useful biomarker for prognosis among patients with ALD. More prospective studies are needed to assess the relevance between LTL and mortality and explore the underlying mechanisms between them.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -272,7 +259,12 @@
"Aged",
"Risk Factors",
"Cardiovascular Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735545",
@@ -289,7 +281,12 @@
"Animals",
"Theranostic Nanomedicine",
"Precision Medicine"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735488",
@@ -307,7 +304,12 @@
"Thyroid Diseases",
"Thyroid Gland",
"Thyroid Hormones"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735485",
@@ -325,7 +327,129 @@
"Parkinson Disease",
"Risk Factors",
"Multiple Sclerosis"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39734095",
+ "Title": "Drug and chemical toxicology",
+ "ArticleTitle": "Metabolic syndrome prevalence in Mexican individuals exposed to polycyclic aromatic hydrocarbons and their association with an increased risk of cardiovascular events.",
+ "Abstract": "Polycyclic aromatic hydrocarbons (PAHs) are an organic chemical family produced during incomplete combustion of organic materials. Besides, PAHs are associated with different detrimental health effects. Therefore, this research was aimed to assess the association between PAHs exposure, metabolic syndrome (MetS) prevalence, and cardiovascular risk in a Mexican population. Urinary 1-hydroxypyrene (1-OHP) was the exposure biomarker quantified. MetS prevalence was defined using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) criteria. Also, we used the atherogenic index of plasma (AIP) as a cardiovascular risk biomarker. The mean urinary 1-OHP level quantified was 2.50\u2009\u00b1\u20091.25\u2009\u00b5mol/mol creatinine. The MetS prevalence found was 35% (\u2009=\u2009222) and 31% (\u2009=\u2009197) using NCEP ATP III and IDF criteria, respectively. The mean AIP value was 0.32\u2009\u00b1\u20090.15. Furthermore, the data analysis showed robust associations between PAH exposure (urinary 1-OHP concentrations), MetS prevalence, and cardiovascular risk (AIP). The real significance of the findings in this study needs to be clarified completely, as MetS and cardiovascular diseases represent a critical challenge in contaminated zones of developing countries such as Mexico.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Metabolic Syndrome",
+ "Mexico",
+ "Male",
+ "Female",
+ "Prevalence",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Pyrenes",
+ "Adult",
+ "Polycyclic Aromatic Hydrocarbons",
+ "Biomarkers",
+ "Environmental Exposure",
+ "Heart Disease Risk Factors",
+ "Aged",
+ "Cross-Sectional Studies",
+ "Environmental Pollutants"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39734043",
+ "Title": "Environmental pollution (Barking, Essex : 1987)",
+ "ArticleTitle": "Exposure to green space, nighttime light, air pollution, and noise and cardiovascular disease risk: A prospective cohort study.",
+ "Abstract": "Current literature lacks information regarding impacts of green spaces on susceptibility to cardiovascular disease (CVD) related to harmful environmental exposures. The UK Biobank cohort study was utilized to investigate whether green spaces can mitigate risks associated with air pollutants, nighttime light, noise, and traffic intensity. Latent Profile Analysis was performed on green spaces and adverse environmental exposures in order to assess individual level exposure. Cox proportional risk models were employed to calculate hazard ratios for the risk of cerebrovascular diseases related to individual and joint adverse environmental exposures. Among participants in domestic garden group (DGG, higher proportion of domestic garden and lower proportion of other green space), adverse environmental exposures was associated with increased risks of cerebrovascular disease. However, these associations were no longer observed in other green space group (GSG, lower proportion of domestic garden and higher proportion of other green space). Interestingly the opposite effect occurred in participants with heart failure (HF) onset, where adverse environmental exposures were associated with increased risk of HF in GSG, and these associations were no longer observed in DGG. Domestic gardens may mitigate the risk of HF caused by adverse environmental exposures, and natural and water environments may offset the risk of cerebrovascular disease. Consequently, there are policy implications for improving urban green space planning to maximize their protective effects.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Male",
+ "Prospective Studies",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Noise",
+ "Air Pollutants",
+ "Light",
+ "Adult",
+ "Cohort Studies",
+ "Risk Factors",
+ "United Kingdom"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39733919",
+ "Title": "American heart journal",
+ "ArticleTitle": "The under-representation of women in cardiovascular clinical trials: State-of-the-art review and ethical considerations.",
+ "Abstract": "This review describes and evaluates the representation of women in cardiovascular randomized controlled trials (RCT), it reports significant under-representation of women in clinical trials both as participants and researchers and discusses the ethical implications of under-representation. The under-representation of women as participants in cardiovascular RCTs is evident in trials investigating cardiovascular drugs, acute coronary syndrome, heart failure and interventional procedures and devices. Under-representation of women is also evident in the authorship of cardiovascular clinical trials and in trial leadership roles, and under-representation of women as trial investigators is independently associated with under- recruitment of women as trial participants. A notable lack of RCTs investigating conditions that disproportionately affect women is also evident, this triad of underrepresentation for women as participants, and investigators, and the lack of RCTs into conditions predominantly experienced by women, all contribute to the gender gap in cardiovascular outcomes. Better representation of women in clinical trials, in trial leadership and authorship is a key factor to address to equity, distributive justice and improve outcomes for women with cardiovascular disease.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Cardiovascular Diseases",
+ "Patient Selection",
+ "Randomized Controlled Trials as Topic",
+ "Authorship",
+ "Clinical Trials as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39733862",
+ "Title": "Brain, behavior, and immunity",
+ "ArticleTitle": "Accelerated development of cardiovascular risk factors mediates risk for major adverse cardiovascular events in posttraumatic stress disorder.",
+ "Abstract": "Individuals with posttraumatic stress disorder (PTSD) have high rates of cardiovascular disease (CVD) and increased cardiometabolic CVD risk factors (CVDRFs, e.g., hypertension, hyperlipidemia, or diabetes mellitus). Nevertheless, it remains unknown whether PTSD accelerates CVDRF development and how that impacts the development of major adverse cardiovascular events (MACE) in a broad population. Furthermore, the underlying mechanisms remain incompletely characterized.We hypothesized that 1) PTSD accelerates CVDRF development, 2) accelerated CVDRF development mediates the PTSD-MACE relationship, and 3) accelerated CVDRF development is partially explained by alterations in neural, autonomic, and inflammatory intermediaries (e.g., stress-associated neural activity [SNA], ventromedial prefrontal cortex [vmPFC] activity, heart rate variability [HRV], and C-reactive protein [CRP]).Subjects (N\u00a0=\u00a084,343) in the Mass General Brigham Biobank were studied over 10\u00a0years. PTSD, CVDRFs, and MACE were identified by diagnostic codes. From participants with available clinical data, neural, autonomic, and inflammatory mediators (e.g., SNA, vmPFC, HRV, and CRP) were assessed.PTSD independently predicted incident CVDRFs (hazard ratio [95\u00a0% confidence interval] = (1.432 [1.287, 1.592], p\u00a0<\u00a00.001) and associated with the accelerated development of a new CVDRF by\u00a0\u223c\u00a04 months versus those without PTSD. The development of new CVDRFs predicted incident MACE (1.736 [1.652, 1.823, p\u00a0<\u00a00.001) and mediated the link between PTSD and MACE (p\u00a0<\u00a00.05) by up to 36.4\u00a0%. Additionally, lower vmPFC activity, lower HRV, and higher CRP were associated with the development of CVDRFs. HRV and CRP significantly mediated the PTSD-CVDRF link.The PTSD-MACE link was partially explained by the accelerated development of CVDRFs. Alterations in neural, autonomic, and inflammatory intermediaries contributed to this association. These findings suggest that greater clinical attention to CVDRFs in individuals with PTSD may attenuate MACE risk.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Stress Disorders, Post-Traumatic",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Adult",
+ "Risk Factors",
+ "Heart Rate",
+ "Aged",
+ "C-Reactive Protein",
+ "Heart Disease Risk Factors",
+ "Prefrontal Cortex"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39733208",
@@ -353,13 +477,18 @@
"Polymorphism, Genetic",
"Alleles",
"Polymorphism, Single Nucleotide"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733181",
"Title": "Scientific reports",
"ArticleTitle": "Assessment of meteorological factors and air pollution impact on cardiovascular mortality using random forest analysis 2017 to 2020.",
- "Abstract": "Air pollution, a global health hazard, significantly impacts mortality, cardiovascular health, mental well-being, and overall human health. This study aimed to investigate the impact of air pollution and meteorological factors on cardiovascular mortality rates in Mashhad City, northeastern Iran in 2017-2020. We utilized a Random Forest (RF) model in this study. We gathered daily meteorological data (pressure, humidity, temperature, solar radiation) from 2017 to 2020, pollutant levels (PM",
+ "Abstract": "Air pollution, a global health hazard, significantly impacts mortality, cardiovascular health, mental well-being, and overall human health. This study aimed to investigate the impact of air pollution and meteorological factors on cardiovascular mortality rates in Mashhad City, northeastern Iran in 2017-2020. We utilized a Random Forest (RF) model in this study. We gathered daily meteorological data (pressure, humidity, temperature, solar radiation) from 2017 to 2020, pollutant levels (PM, PM, SO, NO, CO), and cardiovascular mortality data from the Health System Registration (Sina). The RF model was then applied in Excel and Python to analyze the interplay between these variables. we found that time, air pressure, and temperature significantly impacted cardiovascular mortality. Among pollutants, NO and SO were the most influential. Overall, meteorological factors had a greater impact than pollutants.Furthermore, we discovered that cardiovascular mortality increased with time, higher air pressure, colder seasons, and higher temperatures. Among pollutants, CO, NO, SO, PM, and PM significantly impacted mortality rates. These findings highlight the importance of understanding the relationship between diseases, climatic factors, and pollution. Environmental factors like climate change and air pollution play a significant role in cardiovascular mortality. Therefore, it is vital for individuals, especially those with heart conditions, to pay attention to weather alerts.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -376,7 +505,12 @@
"Climate Change",
"Weather",
"Random Forest"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733164",
@@ -402,7 +536,12 @@
"Risk Factors",
"Hospitalization",
"Aged, 80 and over"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733154",
@@ -426,7 +565,12 @@
"Adult",
"Aged",
"Proportional Hazards Models"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733150",
@@ -445,7 +589,12 @@
"Health Services Accessibility",
"Drugs, Generic",
"Drug Costs"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733137",
@@ -470,7 +619,12 @@
"Young Adult",
"Risk Factors",
"Bayes Theorem"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732966",
@@ -492,35 +646,18 @@
"Cardiovascular Diseases",
"Middle Aged",
"PCSK9 Inhibitors"
- ]
- },
- {
- "PMID": "39732729",
- "Title": "Cardiovascular diabetology",
- "ArticleTitle": "Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.",
- "Abstract": "Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and plays a pivotal role in the pathogenesis of vascular diseases such as atherosclerosis, hypertension, and vascular inflammation. In cardiometabolic diseases, PVAT becomes a significant source of proflammatory adipokines, leading to increased infiltration of immune cells, in cardiometabolic diseases, PVAT becomes a significant source of proinflammatory adipokines, leading to increased infiltration of immune cells, promoting vascular smooth muscle cell proliferation and migrationpromoting vascular smooth muscle cell proliferation and migration. This exacerbates vascular dysfunction by impairing endothelial cell function and promoting endothelial activation. Dysregulated PVAT also contributes to hemodynamic alterations and hypertension through enhanced sympathetic nervous system activity and impaired vasodilatory capacity of PVAT-derived factors. Therapeutic interventions targeting key components of this interaction, such as modulating PVAT inflammation, restoring adipokine balance, and attenuating immune cell activation, hold promise for mitigating obesity-related vascular complications. Lifestyle interventions, pharmacological agents targeting inflammatory pathways, and surgical approaches aimed at reducing PVAT mass or improving adipose tissue function are potential therapeutic avenues for managing vascular diseases associated with obesity and PVAT dysfunction.",
- "Predictions": [
- "Diabetes",
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Animals",
- "Humans",
- "Adipokines",
- "Adipose Tissue",
- "Adiposity",
- "Cardiovascular Diseases",
- "Diabetes Mellitus",
- "Inflammation Mediators",
- "Obesity",
- "Signal Transduction"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732498",
"Title": "BMJ open",
"ArticleTitle": "Investigating context-specific sedentary behaviours and cardiometabolic health in college-based young adults (CONTEXT-SB): a protocol for a longitudinal observational study.",
- "Abstract": "This study has received full ethical approval, and participants provide written informed consent. Our hypothesis is that certain CS-SB will show stronger associations with CMD risk, compared with total sedentary behaviour (T-SB), even after accounting for coexisting lifestyle behaviours. We also expect a range of intra-individual, inter-individual and physical environmental socioecological factors will predict CS-SB. Findings addressing both the primary and any secondary research aims will be submitted for publication in a high-impact peer-reviewed journal.",
+ "Abstract": "Sedentary behaviour (SB) is detrimental to cardiometabolic disease (CMD) risk, which can begin in young adulthood. To devise effective SB-CMD interventions in young adults, it is important to understand which context-specific SB (CS-SB) are most detrimental for CMD risk, the lifestyle behaviours that cluster with CS-SBs and the socioecological predictors of CS-SB.This longitudinal observational study will recruit 500 college-aged (18-24 years) individuals. Two laboratory visits will occur, spaced 12 months apart, where a novel composite CMD risk score (eg, arterial stiffness, metabolic and inflammatory biomarkers, heart rate variability and body fat distribution) will be calculated, and questionnaires to measure lifestyle behaviours and levels of the socioecological model will be administered. After each laboratory visit, total SB (activPAL) and CS-SB (television, transportation, academic/occupational, leisure computer, 'other'; ecological momentary assessment) will be measured across 7\u2009days.This study has received full ethical approval, and participants provide written informed consent. Our hypothesis is that certain CS-SB will show stronger associations with CMD risk, compared with total sedentary behaviour (T-SB), even after accounting for coexisting lifestyle behaviours. We also expect a range of intra-individual, inter-individual and physical environmental socioecological factors will predict CS-SB. Findings addressing both the primary and any secondary research aims will be submitted for publication in a high-impact peer-reviewed journal.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -535,13 +672,18 @@
"Cardiovascular Diseases",
"Universities",
"Cardiometabolic Risk Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732415",
"Title": "Clinica chimica acta; international journal of clinical chemistry",
"ArticleTitle": "High-sensitivity cardiac troponin T and N-terminal b-type natriuretic propeptide are associated with cardiac and all-cause mortality in older adults - A population-based ten-year follow-up study.",
- "Abstract": "Our study shows that older population with higher cTnT and proBNP concentrations have an increased risk of cardiovascular and all-cause mortality. Acknowledging the elevated risk may aid in targeting follow-up, prevention, and treatment adequately and more individually.",
+ "Abstract": "Cardiac troponin T (cTnT) and N-terminal B-type natriuretic propeptide (proBNP) are mainly used as biomarkers to diagnose specific conditions of the heart, but they also have predictive ability. Our aim was to study their associations with cardiovascular and all-cause mortality in an older population in non-acute conditions.A population-based study with a ten-year follow-up. The data comes from a community-based representative sample of an older population with 1260 participants (participation rate 82 %). Associations were analyzed using Cox proportional hazard models.Altogether, 467 (37%) subjects died during the 10-year follow-up period, and 149 of those of a cardiovascular disease. Both elevated cTnT and proBNP concentrations were statistically significantly associated with cardiovascular and all-cause mortality in older adults.Our study shows that older population with higher cTnT and proBNP concentrations have an increased risk of cardiovascular and all-cause mortality. Acknowledging the elevated risk may aid in targeting follow-up, prevention, and treatment adequately and more individually.",
"Predictions": [
"Cardiovascular diseases"
],
@@ -557,1811 +699,1790 @@
"Aged, 80 and over",
"Biomarkers",
"Peptide Fragments"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39732216",
- "Title": "International journal of pharmaceutics",
- "ArticleTitle": "Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals.",
- "Abstract": "Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.",
+ "PMID": "39723782",
+ "Title": "The American journal of nursing",
+ "ArticleTitle": "COVID-19 Infection Shown to Increase the Risk of Adverse Cardiac Events.",
+ "Abstract": "Elevated risk can last for several years after infection.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Antioxidants",
- "Flavonoids",
- "Nanoparticles",
- "Animals",
- "Neuroprotective Agents",
- "Cosmeceuticals",
- "Neoplasms",
- "Biological Availability",
- "Nanoparticle Drug Delivery System",
- "Antineoplastic Agents",
+ "COVID-19",
+ "Risk Factors",
+ "SARS-CoV-2",
"Cardiovascular Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
- "PMID": "39731858",
- "Title": "Maturitas",
- "ArticleTitle": "Wearable devices, ischemic heart disease and cardiovascular outcomes: A systematic review and meta-analysis.",
- "Abstract": "CRD42024586137.",
+ "PMID": "39719674",
+ "Title": "Nanomedicine (London, England)",
+ "ArticleTitle": "Applications of carbon dot-mediated cardiomyocyte maturation in regenerative medicine: a review.",
+ "Abstract": "The maturation of cardiomyocytes (CMs) plays key roles in regenerative medicine and the treatment of cardiovascular diseases via stem cell-derived CMs. Carbon dots (CDs) have good biocompatibility, optical properties, and electrophysical properties and have been widely applied in bioimaging, biosensors, and biotherapy. In this review, we comprehensively summarize recent advances in promoting the maturation of CMs, mainly human pluripotent stem cell-derived CMs, and related regenerative medicine. Moreover, we explore the innovative application of CDs to enhance the maturation of these CMs. Finally, we look forward to the future design and application of CDs in the maturation of CMs in terms of cell therapies.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Myocardial Ischemia",
- "Wearable Electronic Devices",
- "Randomized Controlled Trials as Topic",
- "Myocardial Infarction",
- "Hospitalization",
- "Cardiovascular Diseases",
- "Stroke"
- ]
+ "Regenerative Medicine",
+ "Myocytes, Cardiac",
+ "Carbon",
+ "Cell Differentiation",
+ "Animals",
+ "Quantum Dots",
+ "Pluripotent Stem Cells",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
- "PMID": "39731821",
- "Title": "Biosensors & bioelectronics",
- "ArticleTitle": "All-in-one microfluidic immunosensing device for rapid and end-to-end determination of salivary biomarkers of cardiovascular diseases.",
- "Abstract": "Routine screening for cardiovascular diseases (CVDs) through point-of-care assays for at-home or community-based testing of salivary biomarkers can significantly improve patient outcomes. However, its translatability has been hindered by a dearth of biosensing devices that streamline assay procedures for rapid biomarker quantitation. To address this challenge through end-to-end engineering, we developed an in-house, all-in-one microfluidic immunosensing device that integrates on-chip vibration-enhanced incubation, magnetic-assisted separation using immune magnetic bead probes, and colorimetric readout via absorbance measurements. This device enables probe preparation and one-pot immunoassay procedures on a reusable microfluidic chip. By engaging the vibrator with the reaction chamber, the vibration-enhanced incubation module significantly accelerates immune complex formation, drastically reducing the sample-to-answer timeline of approximately 1\u00a0h required for room temperature enzyme-linked immunosorbent assay (ELISA) to just under 15\u00a0min. We showcase the utility of the device with an on-demand assay for a biomarker panel comprising C-reactive protein (CRP), interleukin 6 (IL-6), and procalcitonin (PCT). The device achieved a linear detection range of 1.75-28\u00a0ng\u00a0mL",
+ "PMID": "39693028",
+ "Title": "Sub-cellular biochemistry",
+ "ArticleTitle": "Role of Vitamin B in Healthy Ageing and Disease.",
+ "Abstract": "B vitamin complex consist of vitamins B1, B2, B5, B6, B9, B12 and is pivotal for overall health, influencing vital functions such as, energy metabolism, DNA maintenance, and healthy immune system. Inadequate B vitamin levels are associated with various health issues, including neurocognitive problems, immune imbalances, and inflammation. In ageing individuals, deficiencies in B vitamins increase the risk of cardiovascular ailments, stroke, cognitive disorders, neurodegeneration, mental health issues, and methylation-related disorders. These result primarily due to changes in glycation, mitochondria, and oxidative stress. Thus, ensuring optimal vitamin B levels in the ageing population may be beneficial in preventing such age-related diseases. In this chapter we discuss the extensive role of B vitamins in the ageing process.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Biosensing Techniques",
- "Biomarkers",
- "Cardiovascular Diseases",
- "Saliva",
- "Lab-On-A-Chip Devices",
- "Immunoassay",
- "Interleukin-6",
- "C-Reactive Protein",
- "Equipment Design",
- "Procalcitonin",
- "Limit of Detection"
- ]
+ "Healthy Aging",
+ "Vitamin B Complex",
+ "Oxidative Stress",
+ "Animals",
+ "Aging",
+ "Neurodegenerative Diseases",
+ "Vitamin B Deficiency",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39731110",
- "Title": "Nutrition journal",
- "ArticleTitle": "Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults.",
- "Abstract": "Our results suggest that IAA, IPA, IAld, and IPA-predicting microbial score are favorably associated with several cardiometabolic risk markers, although IAld may decrease HDL-C levels.",
+ "PMID": "39681436",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Genetic testing assists in the diagnosis and treatment of hereditary cardiovascular diseases].",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
- "Adult",
- "Female",
"Humans",
- "Male",
- "Middle Aged",
- "Bacteria",
- "Biomarkers",
- "Blood Glucose",
- "Cardiometabolic Risk Factors",
"Cardiovascular Diseases",
- "China",
- "Cholesterol, HDL",
- "Cholesterol, LDL",
- "Cohort Studies",
- "East Asian People",
- "Feces",
- "Gastrointestinal Microbiome",
- "Indoleacetic Acids",
- "Indoles",
- "Propionates",
- "Triglycerides"
- ]
+ "Genetic Testing"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "17"
+ }
},
{
- "PMID": "39731068",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.",
- "Abstract": "Among the general American population, baseline CMI levels exhibited an L-shaped nonlinear relationship with all-cause mortality, and the threshold value was 0.98. What's more, CMI may become an effective indicator for CVD, cancer, and all-cause mortality prediction. Further investigation is essential to confirm our findings.",
+ "PMID": "39677503",
+ "Title": "Global heart",
+ "ArticleTitle": "Integrated Antihypertensive and Statin Treatment Protocols for Cardiovascular Disease Prevention in Low- and Middle-Income Countries.",
+ "Abstract": "In low- and middle-income countries where the majority of preventable cardiovascular disease deaths occur, less than 10% of eligible patients receive statins for primary cardiovascular disease prevention. Since 2017, the Global Hearts initiative has implemented simple World Health Organization (WHO) HEARTS hypertension and diabetes treatment protocols. In this editorial, we propose an approach of integrating statin treatment into existing HEARTS hypertension and diabetes protocols as a way of expanding statin coverage in low-and middle-income countries.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
"Cardiovascular Diseases",
- "Middle Aged",
- "Nutrition Surveys",
- "Neoplasms",
- "Adult",
- "Aged",
- "Triglycerides",
- "Cause of Death",
- "Waist Circumference",
- "Cholesterol, HDL",
- "Proportional Hazards Models",
- "Kaplan-Meier Estimate",
- "Body Mass Index",
- "Risk Factors"
- ]
+ "Antihypertensive Agents",
+ "Developing Countries",
+ "Hypertension",
+ "Primary Prevention"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
},
{
- "PMID": "39731058",
- "Title": "BMC psychiatry",
- "ArticleTitle": "The relationship between life's essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults.",
- "Abstract": "This study indicates a significant negative correlation between overall cardiovascular health measured by LE8 scores and depression. Prioritizing interventions targeting lifestyle modifications to alleviate the burden of depression in public health initiatives is crucial.",
+ "PMID": "39675851",
+ "Title": "Seminars in vascular surgery",
+ "ArticleTitle": "The effects of hemodialysis on the cardiovascular system.",
+ "Abstract": "Chronic kidney disease and dialysis-dependent end-stage renal disease are increasing in prevalence in the United States. The costs associated with end-stage renal disease management comprise approximately 1% of the federal government's annual budget. Chronic kidney disease and end-stage renal disease cause significant derangements of the cardiac and vascular system. Pathophysiologic hallmarks include alterations of the renin-angiotensin system, chronically increased sympathetic tone, calcium and phosphate imbalance, pro-inflammatory cytokine release, and uremic toxin accumulation. This results in several pathologies specific to the cardiac and vascular systems, which will each be reviewed separately herein.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "United States",
- "Middle Aged",
- "Depression",
- "Adult",
- "Nutrition Surveys",
"Cardiovascular Diseases",
- "Aged",
- "Severity of Illness Index"
- ]
+ "Cardiovascular System",
+ "Kidney Failure, Chronic",
+ "Renal Dialysis",
+ "Risk Factors",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
},
{
- "PMID": "39730958",
- "Title": "Scientific reports",
- "ArticleTitle": "Combined effect of triglyceride-glucose index and atherogenic index of plasma on cardiovascular disease: a national cohort study.",
- "Abstract": "The triglyceride-glucose (TyG) index and the Atherogenic Index of Plasma (AIP) are both predictors of cardiovascular diseases (CVD). However, their combined and individual contributions to CVD risk are not well understood. This study evaluate the joint and individual associations of the TyG index and AIP with CVD events in middle-aged and older Chinese adults. This nationwide, retrospective cohort study utilized data from CHARLS. The diagnosis of CVD in this study was determined based on self-reported information provided by participants regarding their medical history( heart disease and/or stroke). Cross-sectional analyses in 2011 and longitudinal analyses over a 9-year follow-up were conducted to assess these associations. In the cross-sectional analysis, 8,531 participants were included at baseline. The odds ratio (OR) for TyG alone was 1.06 (95% CI 0.96-1.22) for CVD, while the OR for AIP alone was 1.16 (95% CI 1.02-1.33). Combined analysis showed that compared to the low TyG & low AIP group, the OR for the high TyG & high AIP group was 1.23 (95% CI 1.07-1.42) for CVD. In the survival Analysis, the hazard ratio (HR) for TyG alone was 1.19 (95% CI 1.04-1.35) for CVD, while the HR for AIP alone was 1.25 (95% CI 1.09-1.43). Combined analysis showed that compared to the low TyG & low AIP group, the HR for the high TyG & high AIP group was 1.27 (95% CI 1.10-1.43) for CVD. The findings underscore the significant coexposure effects of the TyG index and AIP on CVD, particularly in middle-aged adults.",
+ "PMID": "39673230",
+ "Title": "Internal medicine journal",
+ "ArticleTitle": "Comparison of cardiovascular risk prediction in type 1 diabetes: an Australian viewpoint.",
+ "Abstract": "Cardiovascular disease (CVD) is a significant burden in individuals with type 1 diabetes mellitus (T1DM). Yet the optimal method of CVD risk stratification remains uncertain. We found that the new Australian CVD risk calculator could overestimate risk category compared with the Steno Type 1 Risk Engine and underestimate risk category compared with the new Swedish/Scottish prediction tool, both of which were validated for T1DM. More research is needed to derive a CVD risk assessment pathway for individuals with T1DM in Australia.",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Diabetes Mellitus, Type 1",
+ "Cardiovascular Diseases",
+ "Australia",
+ "Risk Assessment",
"Male",
- "Triglycerides",
"Female",
+ "Adult",
"Middle Aged",
+ "Heart Disease Risk Factors",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "14"
+ }
+ },
+ {
+ "PMID": "39668055",
+ "Title": "British journal of anaesthesia",
+ "ArticleTitle": "Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity.",
+ "Abstract": "Recent epidemiological studies suggest that chronic pain is a clinically under-recognised cause for cardiovascular morbidity and mortality. Up to 30% of patients undergoing surgery report chronic pain, but the impact of pre-existing pain on postoperative cardiovascular outcomes is not known. Chronic pain and cardiovascular dysfunction share fundamental pathological mechanisms. Chronic pain is a modifiable risk factor for perioperative cardiovascular morbidity.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chronic Pain",
"Cardiovascular Diseases",
- "Blood Glucose",
- "Aged",
- "Retrospective Studies",
- "Cross-Sectional Studies",
- "Atherosclerosis",
- "China",
+ "Postoperative Complications",
"Risk Factors",
- "Longitudinal Studies",
- "Biomarkers"
- ]
+ "Perioperative Care",
+ "Pain, Postoperative"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
},
{
- "PMID": "39730871",
- "Title": "Communications biology",
- "ArticleTitle": "Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.",
- "Abstract": "Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, their underlying pathological mechanisms are still unclear. Leveraging GWAS summary data and using genetic correlation, pleiotropic variants identification, and colocalization analyses, we identified 11 colocalized loci for CVDs-CeVDs-BP (blood pressure), CVDs-CeVDs-LIP (lipid traits), and CVDs-CeVDs-cIMT (carotid intima-media thickness) triplets. No shared causal loci were found for CVDs-CeVDs-T2D (type 2 diabetes) or CVDs-CeVDs-BMI (body mass index) triplets. The 11 loci were mapped to 12 genes, namely CASZ1, CDKN1A, TWIST1, CDKN2B, ABO, SWAP70, SH2B3, LRCH1, FES, GOSR2, RPRML, and LDLR, where both GOSR2 and RPRML were mapped to one locus. They were enriched in pathways related to cellular response to external stimulus and regulation of the phosphate metabolic process and were highly expressed in endothelial cells, epithelial cells, and smooth muscle cells. Multi-omics analysis revealed methylation of two genes (CASZ1 and LRCH1) may play a causal role in the genetic pleiotropy. Notably, these pleiotropic loci are highly enriched in the targets of antihypertensive drugs, which further emphasizes the role of the blood pressure regulation pathway in the shared etiology of CVDs and CeVDs.",
+ "PMID": "39639614",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Cardiovascular health and transgender medicine].",
+ "Abstract": "Gender dysphoria, which describes the distress related to the incongruence between a transgender person's experienced gender and their assigned sex at birth, can be alleviated by specific treatments, notably through gender-affirming hormone therapy and surgeries. Transgender people suffer from an excess of cardiovascular and thrombotic risk, of multifactorial origin and influenced by hormonal therapies and surgeries. In this article, we describe the basis of hormonal treatments for transgender people. The associated thrombotic and cardiovascular risks are detailed, along their mechanisms. Finally, the clinical situations and patient profiles requiring a specialized consultation when making decisions about gender-affirming treatment are discussed.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Cerebrovascular Disorders",
+ "Transgender Persons",
"Cardiovascular Diseases",
- "Cardiometabolic Risk Factors",
- "Genome-Wide Association Study",
- "Genetic Predisposition to Disease",
- "Polymorphism, Single Nucleotide",
- "Carotid Intima-Media Thickness",
- "Genetic Pleiotropy"
- ]
+ "Female",
+ "Male",
+ "Gender Dysphoria",
+ "Transsexualism",
+ "Thrombosis",
+ "Gender-Affirming Procedures"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "6"
+ }
},
{
- "PMID": "39730843",
- "Title": "Scientific reports",
- "ArticleTitle": "Smoking-associated electrocardiographic abnormalities predict cardiovascular mortality.",
- "Abstract": "Background -Smoking is associated with arrhythmia and sudden cardiac death, but the biological mechanisms remain unclear. In electrocardiogram (ECG) recordings abnormal durations of ventricular repolarization (QT interval), atrial depolarization (P wave), and atrioventricular depolarization (PR interval and segment), predict cardiac arrhythmia and mortality. Previous analyses of the National Health and Nutrition Examination Survey (NHANES) database for associations between smoking and ECG abnormalities were incomplete. To elucidate how smoking affects cardiac excitation, we assessed in a nationally representative sample (NHANES III) the association between serum cotinine and P duration, PR interval, PR segment, rate-corrected QT (QTc), QRS duration, and JT interval. Methods and Results-We analyzed data from 5,653 adults using survey-weighted multinomial logistic regression to estimate associations between tobacco use (>\u200915 ng/ml serum cotinine) and short (<\u20095th percentile) or long (>\u200995th percentile) ECG intervals, relative to reference (5-95th percentile). After adjustment for demographics, risk factors, and conduction-altering medications, smoking was associated with a higher odds of short PR interval, PR segment, and QRS, and long JT. Broader effects of smoking on ECG were also assessed by survey-weighted linear regression of continuous cotinine and ECG, which revealed cotinine inversely associated with PR segment and QTc. Over a 22-year follow-up, many ECG abnormalities predicted cardiovascular mortality in smokers, including long JT, QRS, and QTc, and short QRS, whereas only short JT predicted mortality in nonsmokers. Conclusions -Smoking increases likelihood for rapid atrioventricular and ventricular depolarization and slow ventricular repolarization, which may promote cardiac arrhythmia and mortality.",
+ "PMID": "39636514",
+ "Title": "Current atherosclerosis reports",
+ "ArticleTitle": "Statin Use in Children and Adolescents - Dos, Don'ts and Practical Tips.",
+ "Abstract": "We review treatment criteria in the pediatric population, provide practical advice on how and when to prescribe statins, and share tips to improve compliance.Although long-term outcome studies of cardiovascular-related events, such as myocardial infarction (MI) and stroke, are lacking in this population, statin therapy initiated during adolescence has been shown to be safe and effective for up to 20\u00a0years of continuous use. HMG-CoA reductase inhibitors (statins) are the most effective class of drugs for lowering low-density lipoprotein cholesterol (LDL-C) in children and adolescents.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Electrocardiography",
- "Male",
- "Female",
- "Middle Aged",
- "Smoking",
- "Adult",
- "Cotinine",
- "Arrhythmias, Cardiac",
- "Nutrition Surveys",
- "Risk Factors",
- "Aged",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Adolescent",
+ "Child",
+ "Cholesterol, LDL",
"Cardiovascular Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
- "PMID": "39730815",
- "Title": "Scientific reports",
- "ArticleTitle": "Combined association of physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults.",
- "Abstract": "Cardiometabolic risk factors such as obesity, raised blood pressure, high blood glucose and dyslipidemia are emerging health concerns worldwide. Therefore, the aim of this study was to estimate the combined association between physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults. Data was obtained from the National Health Survey of Chile 2016-2017, with a sample of 5995 adult participants. Assessment of Physical activity and depressive symptoms were done using the Global Physical Activity Questionnaire (GPAQ) and the CIDI ShortForm (CIDI-SF), respectively. Multivariable logistic regression was performed to estimate the combined association of physical activity and depressive symptoms with cardiometabolic risk factors. Participants in the category\u2009\u2265\u2009150\u00a0min/Depressive symptoms had the highest prevalence of overweight (OR: 1.55, 95% CI: 1.17-2.05), obesity (OR: 1.97, 95% CI: 1.49-2.59) and high waist circumference (OR: 1.63, 95% CI: 1.39-1.92). Participants in the <\u2009150\u00a0min/No depressive symptoms category had a lower prevalence of overweight/obesity (OR: 0.68, 95% CI: 0.60-0.78) and a 25% reduced high triglycerides prevalence, in comparison with the active category with no depressive symptoms. There is a positive association between depressive symptoms and overweight, obesity and waist circumference among subjects that complete physical activity recommendations but have depressive symptoms.",
+ "PMID": "39631991",
+ "Title": "Mayo Clinic proceedings",
+ "ArticleTitle": "Top 10 Tips for Using Statins in Clinical Practice.",
+ "Abstract": "Statins are the mainstay of cholesterol treatment to prevent atherosclerotic cardiovascular disease. However, significant barriers, including physician and patient factors, prevent the optimal use of this drug class. In this article, we provide 10 clear and simple tips for clinicians when prescribing statins. The tips are based on the current guidelines, an extensive review of the literature, and decades of clinical practice of the senior author. Within the tips, we discuss key components of the guidelines, assessing cardiovascular risk profiles, evaluating drug-drug interactions, addressing adverse effects, and developing treatment plans that include statins and nonstatins. The tips will be useful for primary and specialty clinicians, such as cardiologists, endocrinologists, and nephrologists.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Chile",
- "Male",
- "Female",
- "Exercise",
- "Adult",
- "Middle Aged",
- "Depression",
- "Cardiometabolic Risk Factors",
- "Obesity",
- "Prevalence",
- "Overweight",
- "Risk Factors",
- "Aged",
- "Young Adult",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
"Cardiovascular Diseases",
- "Waist Circumference",
- "Cross-Sectional Studies"
- ]
+ "Practice Guidelines as Topic",
+ "Drug Interactions",
+ "Risk Assessment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
- "PMID": "39730723",
- "Title": "Scientific reports",
- "ArticleTitle": "Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study.",
- "Abstract": "Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases. However, current evidence on the association between CMI and kidney stone risk is limited. The primary objective of this study was to investigate the association between CMI and kidney stones in US adults and to analyze whether diabetes mediates the association. Using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and March 2018, this study examined the association between CMI and kidney stones incidence in US adults. Data were analyzed using a variety of statistical methods, including multifactorial logistic regression, subgroup analysis, restricted cubic spline curves (RCS), saturated threshold effects analysis, and mediated effects analysis. A total of 10,609 subjects were included in this study, of which 972 patients were diagnosed with kidney stones. The results of multifactorial logistic regression analysis after fully adjusting for confounding covariates showed a significant positive association between CMI and kidney stones, with an odds ratio (OR) of 1.29 and a 95% confidence interval (CI) of (1.16,1.44). In addition, there was a non-linear positive association between CMI and kidney stones. The results of mediation analysis showed that diabetes mellitus had a mediating role of 15.3% in the correlation between CMI and kidney stones. The findings of this study indicate that elevated CMI levels are associated with an increased risk of kidney stone formation, with diabetes playing a mediating role. These findings indicate that maintaining CMI within the lower range and addressing glycemic regulation is crucial for the prevention of kidney stones.",
+ "PMID": "39622718",
+ "Title": "Zhonghua nei ke za zhi",
+ "ArticleTitle": "[An overlooked risk factor for pan-vascular disease: hyperinsulinemia].",
+ "Abstract": "",
"Predictions": [
- "Diabetes",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Kidney Calculi",
- "Male",
- "Female",
- "Cross-Sectional Studies",
- "Middle Aged",
- "Adult",
- "Diabetes Mellitus",
- "Nutrition Surveys",
+ "Hyperinsulinism",
"Risk Factors",
- "Aged",
+ "Insulin Resistance",
+ "Metabolic Syndrome",
"Cardiovascular Diseases",
- "United States",
- "Incidence",
- "Logistic Models"
- ]
+ "Cerebrovascular Disorders",
+ "Obesity",
+ "Vascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39730493",
- "Title": "Scientific reports",
- "ArticleTitle": "Heart rate variability parameters indicate altered autonomic tone in subjects with COVID-19.",
- "Abstract": "COVID-19 is associated with long-term cardiovascular complications. Heart Rate Variability (HRV), a measure of sympathetic (SNS) and parasympathetic (PNS) control, has been shown to predict COVID-19 outcomes and correlate with disease progression but a comprehensive analysis that includes demographic influences has been lacking. The objective of this study was to determine the balance between SNS, PNS and heart rhythm regulation in hospitalized COVID-19 patients and compare it with similar measurements in healthy volunteers and individuals with cardiovascular diseases (CVD), while also investigating the effects of age, Body Mass Index (BMI), gender and race. Lead I ECG recordings were acquired from 50 COVID-19 patients, 31 healthy volunteers, and 51 individuals with cardiovascular diseases (CVD) without COVID-19. Fourteen HRV parameters were calculated, including time-domain, frequency-domain, nonlinear, and regularity metrics. The study population included a balanced demographic profile, with 55% of participants being under 65 years of age, 54% identifying as male, and 68% identifying as White. Among the COVID-19 patients, 52% had a BMI\u2009\u2265\u200930 compared to 29% of healthy volunteers and 33% of CVD patients. COVID-19 and CVD patients exhibited significantly reduced time-domain HRV parameters, including SDNN and RMSSD, compared to healthy volunteers (SDNN: 0.02\u2009\u00b1\u20090.02\u00a0s vs. 0.06\u2009\u00b1\u20090.03\u00a0s, p\u2009<\u20090.001; RMSSD: 0.02\u2009\u00b1\u20090.02\u00a0s vs. 0.05\u2009\u00b1\u20090.03\u00a0s, p\u2009=\u20090.08). In the frequency domain, both COVID-19 and CVD patients showed increased low-frequency (LF) power and lower high-frequency (HF) power compared to healthy volunteers (COVID-19 LF: 18.47\u2009\u00b1\u200918.18%, HF: 13.69\u2009\u00b1\u200925.80%; Healthy LF: 23.30\u2009\u00b1\u200911.79%, HF: 22.91\u2009\u00b1\u200921.86%, p\u2009<\u20090.01). The LF/HF ratio was similar in COVID-19 patients (1.038\u2009\u00b1\u20091.54) and healthy volunteers (1.03\u2009\u00b1\u20090.78). Nonlinear parameters such as SD1 were significantly lower in COVID-19 patients (0.04\u2009\u00b1\u20090.04\u00a0s vs. 0.08\u2009\u00b1\u20090.05\u00a0s, p\u2009<\u20090.01), indicating altered autonomic regulation. Variations in HRV were observed based on demographic factors, with younger patients, females, and non-white individuals showing more pronounced autonomic dysfunction. COVID-19 patients exhibit significant alterations in HRV, indicating autonomic dysfunction, characterized by decreased vagal tone and sympathetic dominance, similar to patients with severe cardiovascular comorbidities. Despite higher heart rates, the HRV analysis suggests COVID-19 is associated with substantial disruption in autonomic regulation, particularly in patients with specific demographic risk factors.",
+ "PMID": "39618225",
+ "Title": "British journal of hospital medicine (London, England : 2005)",
+ "ArticleTitle": "SGLT2 Inhibitors in Cardiovascular Medicine: Panacea or Pandora's Box?",
+ "Abstract": "Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are antidiabetic agents that effectively lower blood glucose levels in patients with Type 2 Diabetes Mellitus (T2DM). Beyond their glycemic control properties, SGLT2 inhibitors have demonstrated significant cardiovascular benefits, including reductions in major adverse cardiovascular events. However, the limitations of the pivotal trials investigating these outcomes have not been fully explored. This letter aims to critically assess the major randomized clinical trials that evaluated the cardiovascular effects of SGLT2 inhibitors, highlighting both their strengths and limitations.",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Male",
- "Heart Rate",
- "Female",
- "Middle Aged",
- "Autonomic Nervous System",
- "Aged",
- "Adult",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Diabetes Mellitus, Type 2",
"Cardiovascular Diseases",
- "Electrocardiography",
- "SARS-CoV-2",
- "Body Mass Index"
- ]
+ "Hypoglycemic Agents",
+ "Randomized Controlled Trials as Topic",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
- "PMID": "39730152",
- "Title": "BMJ open",
- "ArticleTitle": "Association of diet quality and nutrient intake with odds of dyslipidaemia in patients with cardiovascular diseases: a hospital based cross-sectional study in Bangladesh.",
- "Abstract": "A high-quality diet was associated with significantly lower odds of dyslipidaemia, hypercholesterolaemia, hypertriglyceridaemia and elevated LDL cholesterol. The study findings highlight the potential of targeted nutritional interventions with a multifaceted approach to managing dyslipidaemia, emphasising the need for personalised dietary guidelines that consider the individual's gender, occupation and BMI.",
+ "PMID": "39613096",
+ "Title": "Indian heart journal",
+ "ArticleTitle": "Influenza vaccine in cardiovascular disease: Current evidence and practice in India.",
+ "Abstract": "Influenza is a common trigger for cardiovascular events. Temporal association studies of influenza and cardiovascular events have well documented this phenomenon. More recently, randomised clinical trials of influenza vaccine have shown the benefit of immunisation in reducing recurrent cardiovascular events, especially in patients with acute coronary syndrome. Despite this overwhelming benefit, its uptake in India is very low. This could be due to a lack of awareness and paucity of evidence of its benefit in tropical countries like India, where the influenza season is variable and spread throughout the year. In this review, we explore these aspects of influenza and cardiovascular diseases and discuss the way ahead.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Bangladesh",
- "Cross-Sectional Studies",
- "Dyslipidemias",
- "Middle Aged",
+ "Influenza Vaccines",
+ "India",
+ "Influenza, Human",
"Cardiovascular Diseases",
- "Aged",
- "Adult",
- "Diet",
- "Aged, 80 and over",
- "Logistic Models",
- "Risk Factors"
- ]
+ "Vaccination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "30"
+ }
},
{
- "PMID": "39729514",
- "Title": "PloS one",
- "ArticleTitle": "Global burden of cardiovascular disease mortality attributable to secondhand smoke, 1990-2019: Systematic analysis of the Global Burden of Disease Study 2019.",
- "Abstract": "Over the past three decades, the epidemiological landscape of CVD mortality associated with secondhand smoke has undergone significant shifts. Notwithstanding global advancements, intensified interventions are paramount in regions experiencing ascending rates.",
+ "PMID": "39596979",
+ "Title": "Medicina (Kaunas, Lithuania)",
+ "ArticleTitle": "Transforming Diabetes Care: The Expanding Role of DPP-4 Inhibitors in Cardiovascular and Renal Protection.",
+ "Abstract": "The approach to managing type 2 diabetes mellitus (T2DM) has significantly progressed, evolving beyond strict glycemic control to addressing the wider complications associated with the disease, including cardiovascular disease (CVD) and chronic kidney disease (CKD) [...].",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Dipeptidyl-Peptidase IV Inhibitors",
+ "Diabetes Mellitus, Type 2",
"Cardiovascular Diseases",
- "Tobacco Smoke Pollution",
- "Global Burden of Disease",
- "Male",
- "Female",
- "Disability-Adjusted Life Years",
- "Middle Aged",
- "Global Health",
- "Adult",
- "Aged",
- "Quality-Adjusted Life Years"
- ]
+ "Renal Insufficiency, Chronic",
+ "Hypoglycemic Agents",
+ "Diabetic Nephropathies"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "27"
+ }
},
{
- "PMID": "39729492",
- "Title": "PloS one",
- "ArticleTitle": "Association between exposure to urinary metal and all-cause and cardiovascular mortality in US adults.",
- "Abstract": "Combining all models, it is possible that Sb may have a more stable impact on all-cause and cardiovascular mortality. Meaningful metal effects in individual statistical models still require careful attention.",
+ "PMID": "39586415",
+ "Title": "Vascular pharmacology",
+ "ArticleTitle": "New insights into the pharmacological inhibition of SRF activity: Key inhibitory targets and mechanisms.",
+ "Abstract": "Serum Response Factor (SRF) is a critical regulatory transcription factor widely expressed across cell types and is essential for animal survival. Excessive SRF activity has been linked to various pathological conditions and diseases, including cardiovascular diseases, cancers and neurodegenerative disorders, making the inhibition of SRF hyperactivity a promising therapeutic strategy. This review summarizes recent advancements in the discovery and development of SRF inhibitors, their regulatory mechanisms, and their respective molecular foundations. These insights deepen our understanding of current therapeutic potentials, paving the way for novel approaches to treat diseases associated with SRF hyperactivity.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
+ "Serum Response Factor",
"Humans",
- "Male",
- "Female",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Adult",
- "United States",
- "Nutrition Surveys",
- "Bayes Theorem",
- "Environmental Exposure",
- "Metals",
- "Aged",
- "Proportional Hazards Models",
- "Cause of Death",
- "Lead"
- ]
+ "Animals",
+ "Signal Transduction",
+ "Molecular Targeted Therapy",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "26"
+ }
},
{
- "PMID": "39729424",
- "Title": "PloS one",
- "ArticleTitle": "Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT study.",
- "Abstract": "Disease networks offer a potential road map of connections between diseases. Several studies have created disease networks where diseases are connected either based on shared genes or Single Nucleotide Polymorphism (SNP) associations. However, it is still unclear to which degree SNP-based networks map to empirical, co-observed diseases within a different, general, adult study population spanning over a long time period. We created a SNP-based phenome-wide association network (PheNet) from a large population using the UK biobank phenome-wide association studies. Importantly, the SNP-associations are unbiased towards much studied diseases, adjusted for linkage disequilibrium, case/control imbalances, as well as relatedness. We map the PheNet to significantly co-occurring diseases in the Norwegian HUNT study population, and further, identify consecutively occurring diseases with significant ordering in occurrence, independent of age and gender in the PheNet. Our analysis reveals an overlap far larger than expected by chance between the two disease networks, with diseases typically connecting within their own category. Upon examining the sequential occurrence of diseases in the HUNT dataset, we find a giant component consisting of mostly cardiovascular disorders. This allows us to identify sequentially occurring diseases that are genetically linked and co-occur frequently, while also highlighting non-sequential diseases. Furthermore, we observe that survivors of severe cardiovascular diseases subsequently often face less severe conditions, but with a reduced time until their next fatal illness. The HUNT sub-PheNet showing both genetically and co-observed diseases offers an interesting framework to study groups of diseases and examine if they, in fact, are comorbidities. We find that the HUNT sub-PheNet offers the possibility to pinpoint exactly which mutation(s) constitute shared cause of the diseases. This could be of great benefit to both researchers and clinicians studying relationships between diseases.",
+ "PMID": "39581923",
+ "Title": "Cell biology and toxicology",
+ "ArticleTitle": "CREB3 protein family: the promising therapeutic targets for cardiovascular and metabolic diseases.",
+ "Abstract": "Significant advancements in cardiovascular and metabolic disease research have been made with the CREB3 protein family. Studies have revealed that members of this family are crucial in the development of these diseases, contributing to the regulation of lipid metabolism, inflammation, and vascular function. These studies provide useful information for future therapeutic strategies in cardiovascular and metabolic diseases.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Polymorphism, Single Nucleotide",
- "Genome-Wide Association Study",
- "Male",
- "Female",
- "Phenotype",
- "Norway",
- "Genetic Predisposition to Disease",
"Cardiovascular Diseases",
- "Phenomics",
- "Middle Aged",
- "Linkage Disequilibrium",
- "Adult"
- ]
+ "Metabolic Diseases",
+ "Cyclic AMP Response Element-Binding Protein",
+ "Animals",
+ "Lipid Metabolism",
+ "Molecular Targeted Therapy",
+ "Inflammation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "25"
+ }
},
{
- "PMID": "39727377",
- "Title": "Iranian journal of kidney diseases",
- "ArticleTitle": "Correlation Analysis of Blood Pressure Variability, Crystalloid Osmotic Pressure, and Cardiovascular Events in Maintenance Hemodialysis Patients.",
- "Abstract": "Elevated crystalloid osmotic pressure, SBP-CV, and DBP-CV are critical risk factors with strong predictive value for predicting CEs in MHD patients.",
+ "PMID": "39577890",
+ "Title": "Advances in kidney disease and health",
+ "ArticleTitle": "Chronic Dialysis Therapies.",
+ "Abstract": "While both in-center and home dialysis modalities have improved life expectancy for people with end-stage kidney disease and have served as a bridge to eventual kidney transplantation, kidney health care providers must be keenly aware of the potential complications associated with these therapies. The following questions aim to shed light on some of the more important potential physiological consequences and medical dilemmas associated with the three primary dialysis modalities including in-center hemodialysis, home hemodialysis, and peritoneal dialysis. Moreover, we hope to highlight that caring for those requiring dialytic therapy necessitates a significant breadth of understanding in other core internal medicine disciplines beyond nephrology itself, including cardiovascular, infectious, and musculoskeletal disease entities.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Retrospective Studies",
- "Middle Aged",
- "Blood Pressure",
- "Renal Dialysis",
- "Crystalloid Solutions",
- "Osmotic Pressure",
- "Aged",
"Kidney Failure, Chronic",
- "Cardiovascular Diseases",
- "Risk Factors",
- "Adult",
- "ROC Curve"
- ]
- },
- {
- "PMID": "39727210",
- "Title": "Journal of the American Heart Association",
- "ArticleTitle": "Inflammatory Markers and Measures of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.",
- "Abstract": "URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02936843, NCT02017171.",
- "Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 1"
+ "Renal Dialysis",
+ "Peritoneal Dialysis",
+ "Hemodialysis, Home",
+ "Cardiovascular Diseases"
],
- "MeshTerms": [
- "Adult",
- "Female",
- "Humans",
- "Male",
- "Middle Aged",
- "Autonomic Nervous System",
- "Autonomic Nervous System Diseases",
- "Biomarkers",
- "Cardiovascular Diseases",
- "Cardiovascular System",
- "Cross-Sectional Studies",
- "Diabetes Mellitus, Type 1",
- "Diabetic Neuropathies",
- "Heart Rate",
- "Inflammation",
- "Inflammation Mediators",
- "Receptors, Urokinase Plasminogen Activator"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "23"
+ }
},
{
- "PMID": "39726401",
- "Title": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
- "ArticleTitle": "Targeting GSK-3\u03b2 for adipose dysfunction and cardiovascular complications of metabolic disease: An\u00a0entangled WNT/\u03b2-catenin question.",
- "Abstract": "Individuals with metabolic syndrome have a high risk of developing cardiovascular disorders that is closely tied to visceral adipose tissue dysfunction, as well as an altered interaction between adipose tissue and the cardiovascular system. In metabolic syndrome, adipose tissue dysfunction is associated with increased hypertrophy, reduced vascularization, and hypoxia of adipocytes, leading to a pro-oxidative and pro-inflammatory environment. Among the pathways regulating adipose tissue homeostasis is the wingless-type mammary tumor virus integration site family (Wnt) signaling pathway, with both its canonical and non-canonical arms. Various modulators of the Wnt signaling have been identified to contribute to the development of metabolic diseases and their cardiovascular complications, with a particularly significant role played by Glycogen Synthase Kinase-3\u03b2 (GSK-3\u03b2). GSK-3\u03b2 levels and activities have various and often contrasting roles in obesity and related metabolic disorders, as well as their cardiovascular sequelae. Here, we explore the possibility that altered Wnt signaling and GSK-3\u03b2 activities could serve as a connection between adipose tissue dysfunction and the development of cardiovascular disease in individuals with metabolic syndrome. We attempt to define a context-specific approach for intervention, which could possibly serve as a novel disease modifying therapy for the mitigation of such complications.",
+ "PMID": "39568350",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[How to answer my patients' questions regarding dietary supplements?].",
+ "Abstract": "Dietary supplements (DS) are products designed to complement the diet, containing vitamins, minerals, or other substances. They can be marketed without evidence-based proof of their effectiveness or clinical safety. In Switzerland, nearly a third of the population uses them for various reasons, including maintaining or improving health. This article reviews the available scientific evidence on the benefits of DS for cardiovascular diseases, cancer, mortality, immunity, physical and cognitive performance. Study results are sometimes mixed, but it seems that health benefits of DS are quite limited, if not nonexistent, and routine use cannot be recommended in healthy adults.",
"Predictions": [
+ "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Glycogen Synthase Kinase 3 beta",
+ "Dietary Supplements",
+ "Switzerland",
"Cardiovascular Diseases",
- "Wnt Signaling Pathway",
- "Animals",
- "Adipose Tissue",
- "beta Catenin",
- "Metabolic Syndrome",
- "Metabolic Diseases"
- ]
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39725874",
- "Title": "BMC cardiovascular disorders",
- "ArticleTitle": "U-shaped association of uric acid to HDL cholesterol ratio (UHR) with ALL-cause and cardiovascular mortality in diabetic patients: NHANES 1999-2018.",
- "Abstract": "This study found a U-shaped relationship between UHR and both ALL-cause and cardiovascular mortality in diabetic population. This suggests that clinicians should control UHR around 9-10 to improve the long-term prognosis of diabetic patients.",
+ "PMID": "39563369",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Hemodialysis dose and frequency should be considered in subgroup analysis.",
+ "Abstract": "The article by Wang et al. titled \"Exploring the mortality and cardiovascular outcomes with SGLT-2 inhibitors in patients with T2DM at dialysis commencement: a health global federated network analysis\" demonstrated that new SGLT-2i use in T2DM patients at the onset of dialysis was associated with a reduced long-term risk of all-cause mortality and MACE over a median follow-up duration of 2.0 years. However, the hemodialysis dose and frequency, which are significant confounding factors, were not included in the study's subgroup analysis. We raise concerns about this limitation, which may affect the study's findings.",
"Predictions": [
- "Diabetes",
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Uric Acid",
- "Nutrition Surveys",
- "Cholesterol, HDL",
- "Middle Aged",
- "Cardiovascular Diseases",
- "Diabetes Mellitus",
- "Biomarkers",
- "Risk Assessment",
- "Cause of Death",
- "United States",
+ "Renal Dialysis",
"Time Factors",
- "Adult",
- "Longitudinal Studies",
- "Prognosis",
- "Aged",
- "Sex Factors",
- "Risk Factors"
- ]
+ "Risk Assessment",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Diabetes Mellitus, Type 2",
+ "Treatment Outcome",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Diabetic Nephropathies",
+ "Protective Factors",
+ "Drug Administration Schedule"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39725697",
- "Title": "Translational psychiatry",
- "ArticleTitle": "Association of \u03b1-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.",
- "Abstract": "This study examines \u03b1-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007-2016) and mortality details from the National Death Index up to December 31, 2019. Including 3329 participants with depression, findings revealed 485 all-cause and 113 cardiovascular deaths. To investigate the nonlinear association between \u03b1-klotho and mortality, the Cox proportional hazards regression model, restricted cubic splines, and two-piecewise Cox proportional hazards model were developed. Analyzes indicated an \"L-shaped\" relationship between ln-transformed \u03b1-klotho levels and all-cause mortality, with a significant threshold effect at 6.53 ln(pg/ml). Below this threshold, ln-transformed \u03b1-klotho levels were inversely related to all-cause mortality (adjusted HR 0.33, 95%CI\u2009=\u20090.19-0.56), with no significant association above it (adjusted HR 1.41, 95%CI\u2009=\u20090.84-2.36). Cardiovascular mortality showed no link to \u03b1-klotho levels. Subgroup analysis shown that, the association between ln-transformed \u03b1-klotho concentration and all-cause mortality was consistent in subgroups according to gender, age, BMI, race, and depression(adjusted P\u2009>\u20090.05). The study uncovers a non-linear \"L-shaped\" association between ln-transformed \u03b1-klotho levels and all-cause mortality in depressed individuals, suggesting \u03b1-klotho assessment as a tool for identifying high-risk patients and guiding preventive strategies to enhance survival.",
+ "PMID": "39562267",
+ "Title": "American heart journal",
+ "ArticleTitle": "Changes in coverage, access, and health status among adults with cardiovascular disease after medicaid work requirements.",
+ "Abstract": "Policymakers have intensified calls to expand work requirements in Medicaid across the United States, which could have implications for low-income adults who experience a high burden of cardiometabolic risk factors and disease. In this difference-in-differences analysis, we found that the implementation of Medicaid work requirements was associated with decreased health insurance coverage, no change in employment status, and a trend towards worse access to care. Our findings suggest that the expansion of work requirements could have major implications for the cardiovascular health of working-age adults in the US.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Klotho Proteins",
+ "United States",
+ "Medicaid",
+ "Cardiovascular Diseases",
+ "Health Services Accessibility",
+ "Insurance Coverage",
"Male",
+ "Adult",
"Female",
- "Cardiovascular Diseases",
"Middle Aged",
- "United States",
- "Prospective Studies",
- "Adult",
- "Nutrition Surveys",
- "Aged",
- "Cause of Death",
- "Depression",
- "Proportional Hazards Models",
- "Mortality",
- "Depressive Disorder"
- ]
+ "Health Status",
+ "Employment",
+ "Poverty",
+ "Insurance, Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39725339",
- "Title": "Pharmacological research",
- "ArticleTitle": "Wnt/\u03b2-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches.",
- "Abstract": "Wnt and Notch signaling pathways play crucial roles in the development and homeostasis of the cardiovascular system. These pathways regulate important cellular processes in cardiomyocytes, endothelial cells, and smooth muscle cells, which are the key cell types involved in the structure and function of the heart and vasculature. During embryonic development, Wnt and Notch signaling coordinate cell fate specification, proliferation, differentiation, and morphogenesis of the heart and blood vessels. In the adult cardiovascular system, these pathways continue to maintain tissue homeostasis and arrange adaptive responses to various physiological and pathological stimuli. Dysregulation of Wnt and Notch signaling has been involved in the pathogenesis of numerous cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and heart failure. Abnormal activation or suppression of these pathways in specific cell types can contribute to endothelial dysfunction, vascular remodeling, cardiomyocyte hypertrophy, impaired cardiac contractility and dead. Understanding the complex interplay between Wnt and Notch signaling in the cardiovascular system has led to the investigation of these pathways as potential therapeutic targets in clinical trials. In conclusion, this review summarizes the current knowledge on the roles of Wnt and Notch signaling in the development and homeostasis of cardiomyocytes, endothelial cells, and smooth muscle cells. It further discusses the dysregulation of these pathways in the context of major cardiovascular diseases and the ongoing clinical investigations targeting Wnt and Notch signaling for therapeutic intervention.",
+ "PMID": "39562150",
+ "Title": "Physiological reports",
+ "ArticleTitle": "Air pollutants as modulators of mitochondrial quality control in cardiovascular disease.",
+ "Abstract": "It is important to understand the effects of environmental factors such as air pollution on mitochondrial structure and function, especially when these changes increase cardiovascular disease risk. Although lifestyle choices directly determine many mitochondrial diseases, increasingly, it is becoming clear that the structure and function of mitochondria may be affected by pollutants found in the atmosphere (e.g., gases, pesticides herbicide aerosols, or microparticles). To date, the role of such agents on mitochondria and the potential impact on cardiovascular fitness is neglected. Here we offer a review of airborne stressors and pollutants, that may contribute to impairments in mitochondrial function and structure to cause heart disease.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Animals",
"Humans",
- "beta Catenin",
+ "Air Pollutants",
"Cardiovascular Diseases",
- "Receptors, Notch",
- "Wnt Signaling Pathway"
- ]
+ "Mitochondria"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39724625",
- "Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
- "ArticleTitle": "STATE OF CARDIOVASCULAR SYSTEM IN SERVICEMEN OF UKRAINE ARMED FORCES AND EMERGENCY WORKERS OF THE CHORNOBYL ACCIDENT. COMPARATIVE ANALYSIS.",
- "Abstract": "The EW group differed from SM in a more severe course of HHD, CHD and HF, they had more severechanges in the structure of left ventricular myocardium. Most likely, this is explained by the fact that the incidenceof HHD and CHD occurs at a younger age, and therefore by the longer duration of these diseases, which led to moresevere pathological myocardial remodeling.",
+ "PMID": "39557535",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Research progress of exercise on autonomic nerve rebalancing].",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Chernobyl Nuclear Accident",
- "Male",
- "Ukraine",
- "Middle Aged",
- "Emergency Responders",
- "Adult",
- "Military Personnel",
- "Electrocardiography",
- "Radiation Exposure",
- "Occupational Exposure",
- "Hypertension",
- "Echocardiography",
- "Cardiovascular System",
- "Cardiovascular Diseases"
- ]
+ "Autonomic Nervous System",
+ "Exercise",
+ "Cardiovascular Diseases",
+ "Exercise Therapy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "19"
+ }
},
{
- "PMID": "39724617",
- "Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
- "ArticleTitle": "LEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).",
- "Abstract": "The overall mortality of Chornobyl clean-up workers from non-tumor diseases tends to increase. Theresults of the risk analysis of dose dependent mortality in the Chornobyl clean-up workers cohort showed a highersensitivity to ionizing radiation of persons of the younger age group (18-39 years old at the date of the accident).The most dangerous period of relative dose-dependent risk of death of Chornobyl clean-up workers due to non-tumordiseases was established - 6-10 years after radiation exposure for all dose subgroups (from 0.05 Gy to 0.7 Gy) relative to the subgroup with a radiation dose < 0.05 Gy.",
+ "PMID": "39557523",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Applications, challenges and future prospects of artificial intelligence in critical and acute cardiovascular care].",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease",
"Cardiovascular diseases"
],
"MeshTerms": [
+ "Artificial Intelligence",
"Humans",
- "Chernobyl Nuclear Accident",
- "Male",
- "Adult",
- "Occupational Exposure",
- "Middle Aged",
- "Ukraine",
- "Radiation Exposure",
- "Radiation Dosage",
- "Occupational Diseases",
"Cardiovascular Diseases",
- "Aged",
- "Gamma Rays",
- "Radiation Injuries",
- "Risk Assessment",
- "Cerebrovascular Disorders",
- "Myocardial Infarction",
- "Respiratory Tract Diseases",
- "Digestive System Diseases",
- "Emergency Responders",
- "Adolescent",
- "Cardiomyopathies"
- ]
+ "Prognosis",
+ "Critical Care",
+ "Big Data",
+ "Critical Illness"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "19"
+ }
},
{
- "PMID": "39724119",
- "Title": "Psychiatria Danubina",
- "ArticleTitle": "SOMA: SCREENING AND SOMATIC HEALTH INTERVENTION PROGRAM FOR PEOPLE WITH SEVERE MENTAL ILLNESS.",
- "Abstract": "Progress in psychiatric treatment has led to important improvements in the quality of life of patients with severe mental illness (SMI). Nevertheless, the life expectancy of patients with SMI remains two decades shorter than that of the general population, and the most prevalent cause of death is cardiovascular disease. Given that the delivery of somatic care to a population of individuals with mental illness is specific, we developed a screening and intervention programme aimed at this vulnerable population. The \"SOMA\" programme is a complex somatic health intervention system consisting of screening and a set of interventions. Risk screening is evaluated automatically; the interventions include dietary intervention, healthy lifestyle education (HSE), physiotherapy, kinesiotherapy, and occupational therapy (KOP). The programme was introduced into the practice of the hospital, and its outcomes were monitored with a pilot population divided into 2 subprogrammes. CV risk factor prevalence study (n= 5481) as the most common CV risk factors identified hypertension (56.6 %) and smoking (55.7 %), high-risk patients proportion was 1364 (27 %). HSE (n=40) enrolled patients improved their body weight. KOP results show that patients with schizophrenia preferred physical activity less than others; 53 % of patients have no physical activity during hospitalization, and spontaneous physical activity depends on BMI in our sample. We observed improvement in cognitive functioning, perception of physical functions, or perceived limitations was comparable to the general population. Results show the usability of the program design; initial screening with two intervention branches can increase motivation for physical activity and adoption of health-promoting behaviors and support a recovery process in SMI patients. SOMA project is unique in the Czech environment, however, larger sample with longer observation period is needed.",
+ "PMID": "39557521",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Artificial intelligence in the diagnosis and treatment of cardiovascular diseases].",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Mental Disorders",
- "Male",
- "Adult",
- "Female",
- "Middle Aged",
- "Schizophrenia",
- "Mass Screening",
- "Healthy Lifestyle",
- "Occupational Therapy",
+ "Artificial Intelligence",
"Cardiovascular Diseases",
- "Pilot Projects",
- "Risk Factors",
- "Physical Therapy Modalities"
- ]
+ "Deep Learning"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "19"
+ }
},
{
- "PMID": "39723980",
- "Title": "Circulation",
- "ArticleTitle": "Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach.",
- "Abstract": "There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular-liver-metabolic health. Metabolic dysfunction and associated insulin resistance, together with the predilection for ectopic fat deposition in the liver and surrounding tissues, are associated with elevated risk of endothelial dysfunction, systemic inflammatory response, and ectopic fat deposition in the epicardium. This complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic dysfunction, valvular calcification, and cardiac arrhythmias. Despite the mounting evidence of mechanistic pathways underpinning MASLD and CVD, current recommendations have not clearly focused upon MASLD as a risk factor or target for intervention in CVD. We have brought together a diverse range of international experts committed to promoting cardiovascular-liver-metabolic health and related outcomes across the globe. The overarching goal of this document is to offer a construct for clinicians in the cardiovascular field with regards to (1) diagnosis and screening of MASLD through the use of noninvasive serum and imaging tests; (2) screening for CVD in all individuals with MASLD regardless of established atherosclerotic risk factors; and (3) the approach to management of MASLD with respect to prevention of CVD through lifestyle, as well as pharmacologic and surgical strategies. To achieve this, the modified Delphi method was applied and a series of evidence-based quality standard recommendations have been identified.",
+ "PMID": "39551564",
+ "Title": "Cardiology clinics",
+ "ArticleTitle": "Cardiovascular Risk in Prostate Cancer.",
+ "Abstract": "Cardiovascular disease is common in patients with prostate cancer and is an important cause of death. Cardiovascular risk factors are frequent in this population and are often not addressed to thresholds recommended by cardiovascular practice guidelines. Androgen deprivation therapy (ADT) reduces muscle strength and increases adiposity, thereby increasing the risk of diabetes and hypertension, although its relationship with adverse cardiovascular events requires confirmation. Androgen receptor signaling inhibitors and CYP17A1 inhibitors may confer incremental risks of hypertension and cardiovascular events to ADT. Lower cardiovascular risk with gonadotropin-releasing hormone antagonists as compared with agonists requires prespecified randomized clinical trial confirmation.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
+ "Male",
+ "Prostatic Neoplasms",
"Cardiovascular Diseases",
- "Delphi Technique",
- "Fatty Liver",
- "Mass Screening",
- "Metabolic Syndrome",
+ "Heart Disease Risk Factors",
+ "Androgen Antagonists",
+ "Global Health",
+ "Risk Assessment",
"Risk Factors"
- ]
- },
- {
- "PMID": "39723782",
- "Title": "The American journal of nursing",
- "ArticleTitle": "COVID-19 Infection Shown to Increase the Risk of Adverse Cardiac Events.",
- "Abstract": "Elevated risk can last for several years after infection.",
- "Predictions": [
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Humans",
- "COVID-19",
- "Risk Factors",
- "SARS-CoV-2",
- "Cardiovascular Diseases"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39723699",
- "Title": "Journal of cachexia, sarcopenia and muscle",
- "ArticleTitle": "Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies.",
- "Abstract": "These two large cohorts provided reliable evidence that gut microbiota alterations in NWO resemble those found in obesity, yet also display unique aspects. This distinct microbiota profile may contribute to heightened cardiometabolic risks in adults with normal BMI.",
+ "PMID": "39551558",
+ "Title": "Cardiology clinics",
+ "ArticleTitle": "Cardio-Oncology Program Building: A Practical Guide.",
+ "Abstract": "The organization of a cardio-oncology clinic and overall program is designed to provide comprehensive cardiovascular care to patients who are at risk of or have developed cardiovascular sequelae during or following cancer treatments. In this article, we summarize the core components of a contemporary cardio-oncology program, including its core members (cardiologists, oncologists, clinical pharmacists, advanced practice providers, nurses, and coordinators), key services (risk assessment, treatment planning, cardiac imaging, intervention, and management), and practical integration within the health care system.",
"Predictions": [
+ "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Gastrointestinal Microbiome",
- "Female",
- "Male",
- "Middle Aged",
- "Obesity",
- "Cohort Studies",
+ "Medical Oncology",
+ "Neoplasms",
"Cardiovascular Diseases",
- "China",
- "Body Mass Index",
- "Adult",
- "Aged"
- ]
+ "Cardiology",
+ "Cardiotoxicity",
+ "Patient Care Team",
+ "Cardio-Oncology"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39722803",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Negative correlation between cardiometabolic index and testosterone in male adults.",
- "Abstract": "Elevated CMI is significantly and negatively correlated with testosterone in male adults.",
+ "PMID": "39551555",
+ "Title": "Cardiology clinics",
+ "ArticleTitle": "Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health.",
+ "Abstract": "Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Testosterone",
- "Cross-Sectional Studies",
- "Adult",
- "Middle Aged",
- "Triglycerides",
- "Nutrition Surveys",
- "Insulin Resistance",
- "Cholesterol, HDL",
- "Aged",
+ "Clonal Hematopoiesis",
"Cardiovascular Diseases",
- "Cardiometabolic Risk Factors",
- "Young Adult"
- ]
+ "Mutation",
+ "Hematopoietic Stem Cells",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39722158",
- "Title": "Journal of evidence-based medicine",
- "ArticleTitle": "Prevalence and Cardio-Renal Comorbidities of Masked Hypertension: A Meta-Analysis.",
- "Abstract": "Masked hypertension is prevalent in adults and associated with increased risks of all-cause mortality, cardiovascular disease, cardiovascular mortality, and composite renal events.",
+ "PMID": "39551552",
+ "Title": "Cardiology clinics",
+ "ArticleTitle": "Cardiovascular Risk Assessment and Prevention in Cardio-Oncology: Beyond Traditional Risk Factors.",
+ "Abstract": "This review goes beyond traditional approaches in cardio-oncology, highlighting often-neglected factors impacting patient care. Social determinants, environment, health care access, and gut microbiome significantly influence patient outcomes. Powerful tools like multi-omics and wearable technologies offer deeper insights into real-world experiences. The future lies in integrating these advancements with established practices to achieve precision cardio-oncology care. By crafting tailored therapies and continuously updating comprehensive management plans based on real-time data, we can unlock the full potential of personalized care for all patients.",
"Predictions": [
+ "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
"Cardiovascular Diseases",
- "Comorbidity",
- "Kidney Diseases",
- "Masked Hypertension",
- "Prevalence"
- ]
+ "Neoplasms",
+ "Risk Assessment",
+ "Medical Oncology",
+ "Heart Disease Risk Factors",
+ "Risk Factors",
+ "Cardiology",
+ "Cardio-Oncology"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39721760",
- "Title": "Thorax",
- "ArticleTitle": "Inhaled corticosteroids and major cardiovascular events in people with chronic obstructive pulmonary disease.",
- "Abstract": "ICS did not reduce MACE, except HF, likely by reducing misclassified COPD exacerbations.",
+ "PMID": "39546744",
+ "Title": "Diabetes",
+ "ArticleTitle": "Identification of Metabolic Patterns in Korean Patients With Type 2 Diabetes and Their Association With Diabetes-Related Complications.",
+ "Abstract": "Identifying patterns of metabolic heterogeneity in type 2 diabetes (T2D) can help in the development of optimal treatment strategies. We aimed to identify metabolic patterns in patients with T2D in the Republic of Korea and analyze the risk of developing diabetes-related complications according to patterns. We identified three distinct metabolic patterns and observed that each pattern was associated with a heightened risk of developing various cardiovascular diseases. These findings highlight the necessity of devising treatment strategies based on these patterns to prevent diabetes-related complications.",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Pulmonary Disease, Chronic Obstructive",
- "Male",
+ "Diabetes Mellitus, Type 2",
+ "Republic of Korea",
"Female",
+ "Male",
+ "Middle Aged",
+ "Diabetes Complications",
"Aged",
- "Administration, Inhalation",
- "Bronchodilator Agents",
"Cardiovascular Diseases",
- "England",
- "Adrenal Cortex Hormones",
- "Middle Aged",
- "Heart Failure",
- "Acute Coronary Syndrome"
- ]
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39721361",
- "Title": "Sleep medicine",
- "ArticleTitle": "Chinese consensus report on the assessment and management of obstructive sleep apnea in patients with cardiovascular disease: 2024 edition.",
- "Abstract": "As cardiovascular disease (CVD) incidence and mortality rates continue to rise in China, the importance of identifying and managing CVD risk factors grows. Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder, affecting an estimated 936 million individuals aged 30-69 worldwide, with China leading globally with about 176 million affected. Increasing research indicates a close association between OSA and the onset and progression of various CVD, significantly affecting outcomes. However, OSA has long been underrecognized and undertreated in CVD clinical practice. To address this gap, a multidisciplinary expert panel developed evidence-based recommendations using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology and the Delphi process. This consensus provides 17 recommendations on core clinical issues such as screening, diagnosis, treatment, and follow-up of CVD patients with OSA, aiming to standardize care and improve patient outcomes. The recommendations were informed by current evidence-based research and extensive expert consensus discussions. This approach seeks to support clinical decision-making, improve the quality of care, and address the unique challenges of managing OSA in Chinese CVD patients.",
+ "PMID": "39544056",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[COMISA: co-morbid insomnia and sleep apnea].",
+ "Abstract": "Obstructive sleep apnea (OSA) is a frequent pathology with clinical implications. Its comorbidity with the complaint of insomnia is common, and has been increasingly studied in recent years, due to the multiple negative synergies highlighted by these two conditions, notably on all-cause excess mortality, cardiovascular risk, quality of life and sleep, as well as mental health. This comorbidity between insomnia and sleep apnea has recently been referred to as COMISA (\u00abco-morbid insomnia and sleep apnea\u00bb). In this article, we explore the relationship between OSA and insomnia, as well as its consequences and currently available treatments, through an analysis of the existing literature.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
- "Sleep Apnea, Obstructive",
"Humans",
- "Cardiovascular Diseases",
- "China",
- "Consensus",
- "Risk Factors",
- "Delphi Technique",
- "East Asian People"
- ]
+ "Sleep Initiation and Maintenance Disorders",
+ "Comorbidity",
+ "Sleep Apnea, Obstructive",
+ "Quality of Life",
+ "Sleep Apnea Syndromes",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39720249",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Traditional versus intensive blood glucose control: long-term target range duration and cardiovascular disease risk and all-cause mortality - a real-world cohort study.",
- "Abstract": "In patients with type 2 diabetes, achieving near-normal blood glucose levels appears to significantly reduce the risk of diabetes-related cardiovascular outcomes.",
+ "PMID": "39541734",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Duration of diabetes, glycemic control, and low heart rate variability: The Atherosclerosis Risk in Communities (ARIC) study.",
+ "Abstract": "Persons with long-standing, poorly controlled diabetes or recent hyperglycemia had the highest burden of cardiac autonomic neuropathy. Cardiac autonomic neuropathy contributed to elevated long-term incidence of cardiovascular disease and mortality even in persons with well-controlled diabetes.",
"Predictions": [
"Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Cardiovascular Diseases",
- "Male",
+ "Glycemic Control",
+ "Heart Rate",
+ "Diabetic Neuropathies",
"Female",
- "Diabetes Mellitus, Type 2",
+ "Male",
+ "Atherosclerosis",
"Middle Aged",
+ "Time Factors",
+ "Diabetes Mellitus, Type 2",
"Blood Glucose",
- "Glycemic Control",
- "Cohort Studies",
- "Aged",
- "Follow-Up Studies",
"Risk Factors",
- "Hypoglycemic Agents",
- "Adult",
- "Cause of Death",
- "China"
- ]
+ "Incidence",
+ "Diabetic Angiopathies",
+ "Diabetic Cardiomyopathies",
+ "Hyperglycemia",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39719690",
- "Title": "Chinese medical journal",
- "ArticleTitle": "Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications.",
- "Abstract": "This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer survival rates have improved over the last two decades, the risk of CVD has risen over time in patients with cancer. CVD and cancer share similar risk factors and a common pathophysiology involving inflammation. Many chemotherapeutic agents used to treat cancer are associated with cardiovascular complications (such as heart failure, myocardial infarction, and thrombosis). Current evidence indicates a significant burden of CVD in patients with cancer, particularly in the first year following cancer diagnosis, with elevated risk persisting beyond this period. This short- and long-term risk of CVD may vary depending on the cancer type and treatment regimen. Early identification of potential cardiovascular risk in patients with cancer, can lead to more favorable clinical and survival outcomes. Given the acute and long-term consequences, patients with cancer require increased cardiovascular care and lifestyle optimization. This article offers valuable insights into the cardiovascular burden and needs of patients with cancer. It is intended for a general medical research readership interested in the intersection of cardiology and oncology.",
+ "PMID": "39525384",
+ "Title": "Methodist DeBakey cardiovascular journal",
+ "ArticleTitle": "Intersectionality and Social Drivers of Health in Cardiovascular Care.",
+ "Abstract": "Social drivers of health (SDOH) are a significant contributor to persistent cardiovascular health disparities in the United States and globally. SDOH include psychosocial, environmental, socioeconomic, cultural, and governmental factors that impact health behaviors and outcomes. Multiple social drivers have been associated with trends in cardiovascular disease risk and health outcomes. These social drivers intersect in complex ways, and applying the concept of intersectionality is critical when considering ways to best address SDOH in cardiovascular care. Applying intersectionality, which considers the unique combination of social drivers associated with a community, allows for tailored interventions to address cardiovascular health disparities.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Neoplasms",
"Cardiovascular Diseases",
- "Prognosis",
+ "Social Determinants of Health",
+ "Health Status Disparities",
+ "Healthcare Disparities",
+ "Socioeconomic Factors",
+ "Risk Assessment",
+ "Heart Disease Risk Factors",
+ "Health Behavior",
"Risk Factors",
- "Antineoplastic Agents"
- ]
+ "United States"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "14"
+ }
},
{
- "PMID": "39719674",
- "Title": "Nanomedicine (London, England)",
- "ArticleTitle": "Applications of carbon dot-mediated cardiomyocyte maturation in regenerative medicine: a review.",
- "Abstract": "The maturation of cardiomyocytes (CMs) plays key roles in regenerative medicine and the treatment of cardiovascular diseases via stem cell-derived CMs. Carbon dots (CDs) have good biocompatibility, optical properties, and electrophysical properties and have been widely applied in bioimaging, biosensors, and biotherapy. In this review, we comprehensively summarize recent advances in promoting the maturation of CMs, mainly human pluripotent stem cell-derived CMs, and related regenerative medicine. Moreover, we explore the innovative application of CDs to enhance the maturation of these CMs. Finally, we look forward to the future design and application of CDs in the maturation of CMs in terms of cell therapies.",
+ "PMID": "39525373",
+ "Title": "Methodist DeBakey cardiovascular journal",
+ "ArticleTitle": "Zip Code Health Disparities: Mapping Cardiovascular Inequities at the Neighborhood Level.",
+ "Abstract": "This review examines the multifaceted impact of neighborhood-level social determinants of health (SDOH) on cardiovascular disease (CVD) and outlines strategic interventions for mitigating cardiovascular health inequities. Research highlights that environmental and socioeconomic factors within a neighborhood-including education, unemployment, healthcare access, racial segregation, systemic inequities, air quality, housing quality, and other SDOH-influence CVD outcomes. Addressing CVD disparities necessitates a comprehensive strategy that integrates policy reform, enhanced community infrastructure, improved healthcare access, and community empowerment and leverages innovative technology to create equitable health outcomes across diverse populations.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Regenerative Medicine",
- "Myocytes, Cardiac",
- "Carbon",
- "Cell Differentiation",
- "Animals",
- "Quantum Dots",
- "Pluripotent Stem Cells",
- "Cardiovascular Diseases"
- ]
+ "Cardiovascular Diseases",
+ "Social Determinants of Health",
+ "Health Status Disparities",
+ "Residence Characteristics",
+ "Healthcare Disparities",
+ "Health Services Accessibility",
+ "Socioeconomic Factors",
+ "Risk Assessment",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "14"
+ }
},
{
- "PMID": "39719571",
- "Title": "BMC public health",
- "ArticleTitle": "Association between the female hormone intake and cardiovascular disease in the women: a study based on NHANES 1999-2020.",
- "Abstract": "Although many studies have reported the relationship between female hormone intake and cardiovascular disease (CVD) development, their association has not been fully elucidated and defined, based on data from the Third National Health and Nutrition Examination Survey intending to assess the health and nutritional status of non-institutionalized children and adults in the United States. This study examined the relationship between female hormone intake and coronary artery disease (CVD) development in 38,745 women, averaging 38.10\u2009\u00b1\u200912.59\u00a0years in age. We explored the association between hormone intake and CVD incidence, considering various social determinants of health (SDOH) with statistical methods like Chi-square tests, logistic regression, and stratified Chi-square analysis. Our findings reveal a complex relationship between female hormone intake and CVD development. Hormones appear to reduce CVD risk in women over 60\u00a0years old. However, hormone intake correlates with increased CVD risk in highly educated women. Socioeconomic status also influences this relationship; while hormones pose a risk factor for heart failure and stroke in impoverished or wealthy women, they serve as a protective factor against CVD for middle-income women. Additionally, hormonal intake seems beneficial for women who experienced menarche between 13 and 15\u00a0years old, menopause between 30 and 49, and had 7-9 pregnancies, especially when coupled with a diet low in sugar, fat, cholesterol, and adequate folic acid intake. These results indicate that while hormones can prevent CVD under specific conditions, their impact can be detrimental in different SDOH contexts. In conclusion, while appropriate hormone intake can prevent CVD, its effects vary across different demographic and health backgrounds. This underscores the necessity for meticulous screening of SDOH factors in clinical settings to maximize the protective benefits of hormones against CVD.",
+ "PMID": "39533678",
+ "Title": "Zhonghua yi xue za zhi",
+ "ArticleTitle": "[Pay attention to the impact of cardiopulmonary comorbidities on the management strategies of pulmonary arterial hypertension].",
+ "Abstract": "With the increasing age of patients with pulmonary arterial hypertension (PAH) at diagnosis, multiple comorbidities are more and more common in these patients, especially cardiopulmonary diseases. This article introduces the incidence of PAH combined with cardiovascular disease and/or chronic lung disease, elaborates on the impact of cardiopulmonary comorbidities on the diagnosis, prognosis, and targeted drug treatment strategies of PAH, and proposes management recommendations for PAH patients with comorbidities, aiming to further improve the diagnosis and treatment level of pulmonary hypertension.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Female",
- "Nutrition Surveys",
- "Adult",
- "United States",
- "Middle Aged",
+ "Comorbidity",
+ "Pulmonary Arterial Hypertension",
+ "Hypertension, Pulmonary",
"Cardiovascular Diseases",
- "Risk Factors",
- "Young Adult",
- "Incidence"
- ]
+ "Lung Diseases",
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39719456",
- "Title": "Scientific reports",
- "ArticleTitle": "Association of cardiovascular disease on cancer: observational and mendelian randomization analyses.",
- "Abstract": "Extensive research is needed to examine the association between cardiovascular disease (CVD) and cancer. The observational study is based on data collected from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). To assess the connection between CVDs and cancer, we used a weighted multivariable logistic regression analysis with as many confounding factors as feasible included in the model. By employing Mendelian randomization (MR), the unbiased causal relationship between CVDs and cancers was ascertained. The primary analytical approach employed the Inverse Variance Weighted methodology. In cross-sectional study, a positive correlation was observed between CVD and cancer (Model 3, Odds ratio 1.26, 95% confidence interval 1.01\u2009~\u20091.57, p\u2009=\u20090.040). However, MR analysis indicated a negative causal relationship between certain subtypes of CVD and specific cancers, with effect sizes for coronary heart disease and lung cancer (\u03b2 = -\u00a04.759, p\u2009=\u20090.002), breast cancer (\u03b2 = -\u00a02.684, p\u2009=\u20090.026), colorectal cancer (\u03b2 = -\u00a04.581, p\u2009=\u20090.042), liver cancers (\u03b2 = -\u00a019.264, p\u2009=\u20090.028), and stroke with prostate cancer (\u03b2 = -\u00a00.299, p\u2009=\u20090.017), with no evidence of a positive correlation. Results from the reverse MR causal analysis revealed a positive correlation between prostate cancer and angina pectoris. An observational study linked CVDs risk to cancer risk. MR analysis has shown that the expected incidence of CVDs can reduce the probability of developing certain forms of cancer. Further investigation is required to examine the clinical correlations and underlying processes between these two illnesses.",
+ "PMID": "39531017",
+ "Title": "Ugeskrift for laeger",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "This review outlines the workflow for patients and relatives with suspected inherited cardiovascular disease, diagnostic criteria, inheritance patterns, and \u00bbred flags\u00ab for selected conditions. Evaluation for inherited cardiovascular disease typically includes the index patient (proband) and relatives, emphasizing the importance of assessment at specialized clinics. Most inherited cardiovascular conditions have an autosomal dominant inheritance, but other patterns are seen.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Mendelian Randomization Analysis",
- "Neoplasms",
- "Male",
- "Female",
+ "Denmark",
+ "Genetic Testing",
+ "Medical History Taking",
+ "Workflow",
+ "Inheritance Patterns",
"Cardiovascular Diseases",
- "Cross-Sectional Studies",
- "Middle Aged",
- "Risk Factors",
- "Aged",
- "Nutrition Surveys",
- "Adult"
- ]
+ "Risk Assessment",
+ "Genetic Counseling",
+ "Pedigree"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39719431",
- "Title": "Journal of the American Heart Association",
- "ArticleTitle": "Association Between Sleep Duration and Cardiovascular Disease Among Asian Americans.",
- "Abstract": "Our study highlights the heterogeneity of CVD prevalence associated with suboptimal sleep duration among Asian American adults. Future studies should consider how different measures of sleep duration and quality affect CVD outcomes among disaggregated Asian American subgroups.",
+ "PMID": "39508541",
+ "Title": "Praxis",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Asian",
+ "Aspirin",
+ "Aged",
+ "Cardiovascular Diseases",
"Male",
+ "Platelet Aggregation Inhibitors",
"Female",
- "Cardiovascular Diseases",
- "Middle Aged",
"United States",
- "Prevalence",
- "Adult",
- "Aged",
- "Sleep",
- "Time Factors",
- "Risk Factors",
- "Risk Assessment",
- "Cross-Sectional Studies",
- "Health Surveys",
- "Sleep Duration"
- ]
+ "Aged, 80 and over"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39719421",
- "Title": "Journal of the American Heart Association",
- "ArticleTitle": "Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease.",
- "Abstract": "Among patients with CKD stages 3b/4, patients with hyperkalemia experienced significantly higher risks of major adverse cardiovascular events and arrhythmia in hospital settings relative to patients without hyperkalemia.",
+ "PMID": "39496174",
+ "Title": "Annals of internal medicine",
+ "ArticleTitle": "In T2D, SGLT-2 inhibitor effects on CV and kidney outcomes were consistent regardless of GLP-1 receptor agonist use.",
+ "Abstract": "Apperloo EM, Neuen BL, Fletcher RA, et al. Lancet Diabetes Endocrinol. 2024;12:545-557. 38991584.",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Hyperkalemia",
- "Male",
- "Renal Insufficiency, Chronic",
- "Female",
- "Aged",
- "Middle Aged",
"Cardiovascular Diseases",
- "Risk Assessment",
- "Risk Factors",
- "Potassium",
- "Aged, 80 and over",
- "Arrhythmias, Cardiac",
- "Retrospective Studies"
- ]
+ "Diabetes Mellitus, Type 2",
+ "Hypoglycemic Agents",
+ "Randomized Controlled Trials as Topic",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Meta-Analysis as Topic",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "4"
+ }
},
{
- "PMID": "39719405",
- "Title": "Journal of the American Heart Association",
- "ArticleTitle": "Cardiovascular Health Status in US Adults With Chronic Diseases: National Health and Nutrition Examination Survey (NHANES), 2013-2018.",
- "Abstract": "CVH is significantly poorer in adults with many chronic diseases compared with unaffected adults. These data suggest the utility of the LE8 score to identify groups for targeted optimization of CVH to enhance primary and secondary prevention efforts for cardiovascular disease and potentially for concomitant chronic diseases of aging.",
+ "PMID": "39456214",
+ "Title": "Biomolecules",
+ "ArticleTitle": "Understanding the Key Determinants of Cardiovascular and Metabolic Disease Progression to Develop Effective Therapeutic Strategies.",
+ "Abstract": "Cardiovascular disease (CVD) is a general term that is used to describe a range of conditions affecting the cardiovascular system [...].",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Middle Aged",
- "Female",
- "Adult",
- "Nutrition Surveys",
- "Chronic Disease",
- "United States",
"Cardiovascular Diseases",
- "Aged",
- "Health Status",
- "Young Adult"
- ]
+ "Metabolic Diseases",
+ "Disease Progression",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "26"
+ }
},
{
- "PMID": "39719315",
- "Title": "Acta medica Okayama",
- "ArticleTitle": "Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk.",
- "Abstract": "Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers.",
+ "PMID": "39454743",
+ "Title": "Bone",
+ "ArticleTitle": "Cardiovascular risk assessment for osteoporosis patients considering Romosozumab.",
+ "Abstract": "Cardiovascular risk scoaring tools are suitable for but not interchangable within the osteoporosis clinic.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Kidney Neoplasms",
- "Male",
- "Nephrectomy",
- "Female",
- "Middle Aged",
- "Propensity Score",
- "Aged",
- "Retrospective Studies",
+ "Antibodies, Monoclonal",
"Cardiovascular Diseases",
- "Risk Factors",
- "Carcinoma, Renal Cell"
- ]
+ "Heart Disease Risk Factors",
+ "Osteoporosis",
+ "Risk Assessment",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "26"
+ }
},
{
- "PMID": "39719183",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD.",
- "Abstract": "NAFLD-non-MASLD patients with 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L are still at high risk of poor clinical outcomes. These findings support including 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L as a component of the metabolic dysfunction definition.",
+ "PMID": "39437384",
+ "Title": "Journal of medical Internet research",
+ "ArticleTitle": "Gender Bias in AI's Perception of Cardiovascular Risk.",
+ "Abstract": "The study investigated gender bias in GPT-4's assessment of coronary artery disease risk by presenting identical clinical vignettes of men and women with and without psychiatric comorbidities. Results suggest that psychiatric conditions may influence GPT-4's coronary artery disease risk assessment among men and women.",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
"Female",
"Male",
+ "Sexism",
+ "Cardiovascular Diseases",
"Middle Aged",
- "Non-alcoholic Fatty Liver Disease",
- "Blood Glucose",
- "Retrospective Studies",
- "Glucose Tolerance Test",
+ "Risk Assessment",
+ "Artificial Intelligence",
"Adult",
- "Aged",
- "Cardiovascular Diseases",
- "Risk Factors",
- "Diabetes Mellitus, Type 2"
- ]
+ "Heart Disease Risk Factors",
+ "Coronary Artery Disease"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "22"
+ }
},
{
- "PMID": "39719182",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study.",
- "Abstract": "YKL-40 is a prognostic biomarker for most CVEs, and even more so for all-cause mortality, primarily driven by cancer-related causes.",
+ "PMID": "39428376",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Fix-dose combination in the prevention and management of cardiovascular diseases].",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 2",
- "Chitinase-3-Like Protein 1",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Denmark",
"Cardiovascular Diseases",
- "Biomarkers",
- "Cohort Studies",
- "C-Reactive Protein"
- ]
+ "Drug Combinations"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39718412",
- "Title": "Journal of human nutrition and dietetics : the official journal of the British Dietetic Association",
- "ArticleTitle": "Tea Consumption and Long-Term Mortality in Very Elderly Individuals With or Without Cardiovascular and Cerebrovascular Disease: Findings From a Sample of 19664 Chinese.",
- "Abstract": "Among very elderly Chinese individuals, frequent tea consumption was associated with reduced mortality over the short term, particularly in those who maintained this habit throughout life. No significant interaction effect was observed between pre-existing CCD and the mortality benefits of tea consumption.",
+ "PMID": "39428375",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Applications of multiple exposure data in cardiovascular longitudinal studies].",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Tea",
- "Cerebrovascular Disorders",
"Cardiovascular Diseases",
- "China",
- "Aged, 80 and over",
"Longitudinal Studies",
- "Proportional Hazards Models",
- "Longevity",
- "Mortality",
- "Middle Aged",
- "East Asian People"
- ]
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39717954",
- "Title": "Molecular medicine reports",
- "ArticleTitle": "Insights into renal damage in hyperuricemia: Focus on renal protection (Review).",
- "Abstract": "The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction\u2011associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage. A number of randomized controlled clinical trials have investigated the effectiveness of UA\u2011lowering therapies in preventing kidney disease progression. The present review provided fundamental insights into the pathogenesis, principles and therapeutic approaches for managing hyperuricemia in patients with aforementioned diseases and assesses the effect of uric acid\u2011lowering therapy on diabetic nephropathy, systemic lupus erythematosus, CKD, CVD and obesity progression.",
+ "PMID": "39428362",
+ "Title": "Zhonghua xin xue guan bing za zhi",
+ "ArticleTitle": "[Collaborative innovation accelerates cardiovascular randomized controlled trial in China].",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
+ "China",
"Humans",
- "Hyperuricemia",
- "Uric Acid",
- "Renal Insufficiency, Chronic",
- "Kidney",
- "Animals",
- "Obesity",
- "Diabetes Mellitus, Type 2",
+ "Randomized Controlled Trials as Topic",
"Cardiovascular Diseases",
- "Gout"
- ]
+ "Research Design"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39717783",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Crosstalk between periodontitis and cardiovascular risk.",
- "Abstract": "Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide.",
+ "PMID": "39419664",
+ "Title": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society",
+ "ArticleTitle": "Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease.",
+ "Abstract": "There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular disease. This review will describe the various roles of PAPP-A with a focus on atherosclerosis, neointimal hyperplasia, and acute coronary syndrome in animal models and in humans.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
- "Animals",
"Humans",
+ "Pregnancy-Associated Plasma Protein-A",
"Cardiovascular Diseases",
- "Heart Disease Risk Factors",
- "Periodontitis"
- ]
+ "Animals",
+ "Female",
+ "Pregnancy",
+ "Atherosclerosis",
+ "Acute Coronary Syndrome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "18"
+ }
},
{
- "PMID": "39717036",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Added sugar intake and its associations with incidence of seven different cardiovascular diseases in 69,705 Swedish men and women.",
- "Abstract": "The findings suggest that the associations between added sugar intake and cardiovascular diseases vary by disease and source of added sugar. The findings emphasize the adverse health effects of sweetened beverage consumption and indicate higher cardiovascular diseases risks with lower treats intake, which warrants further investigation.",
+ "PMID": "39405367",
+ "Title": "Circulation. Cardiovascular quality and outcomes",
+ "ArticleTitle": "Challenges and Opportunities in Disease Surveillance and Cardiovascular Epidemiology for the Centennial Collection.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Sweden",
- "Middle Aged",
- "Female",
"Cardiovascular Diseases",
- "Aged",
- "Aged, 80 and over",
- "Incidence",
- "Surveys and Questionnaires",
- "Risk Factors",
- "Sugar-Sweetened Beverages",
- "Diet",
- "Dietary Sugars"
- ]
+ "Periodicals as Topic",
+ "Time Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "15"
+ }
},
{
- "PMID": "39717032",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Association between phenotypic age and mortality risk in individuals with obesity: a retrospective cohort study.",
- "Abstract": "PAA is an independent predictor of all-cause, cardiovascular, and cancer mortality in obese individuals. This study highlights the importance of PAA in mortality risk assessment and health management in the obese population.",
+ "PMID": "39392636",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Validating the PREVENT Equations-A Contemporary Update to Cardiovascular Risk Assessment.",
+ "Abstract": "",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
+ "Cardiovascular Diseases",
+ "Risk Assessment",
"Male",
"Female",
- "Obesity",
"Middle Aged",
- "Adult",
- "Retrospective Studies",
- "Neoplasms",
- "Nutrition Surveys",
- "Cardiovascular Diseases",
- "Phenotype",
- "Proportional Hazards Models",
- "Risk Factors",
- "Cause of Death",
- "Aged",
- "Age Factors",
- "Body Mass Index",
- "Kaplan-Meier Estimate"
- ]
+ "Heart Disease Risk Factors",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39716258",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.",
- "Abstract": "Overall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.",
+ "PMID": "39384268",
+ "Title": "JACC. Cardiovascular imaging",
+ "ArticleTitle": "Calcification vs Inflammation: The Modern Toolkit for Cardiovascular Risk Assessment.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Biomarkers",
- "Blood Glucose",
+ "Risk Assessment",
+ "Predictive Value of Tests",
+ "Heart Disease Risk Factors",
+ "Vascular Calcification",
+ "Inflammation",
+ "Prognosis",
"Cardiovascular Diseases",
- "Cross-Sectional Studies",
- "Diabetes Mellitus, Type 2",
- "Insulin Resistance",
- "Metabolic Syndrome",
- "Triglycerides"
- ]
+ "Inflammation Mediators"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "10"
+ }
},
{
- "PMID": "39715781",
- "Title": "Scientific reports",
- "ArticleTitle": "Association of life's essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease.",
- "Abstract": "The American Heart Association has updated the cardiovascular health (CVH) assessment tool, referred to as the Life's Essential 8 (LE8). Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease worldwide and is linked to an elevated risk of mortality. We aimed to explore the association of LE8 with all cause and cause-specific mortality in MASLD in a prospective cohort study. A total of 10,050 participants with MASLD from the NHANES 2005-2018 dataset were included in the study. LE8 was evaluated by combining four health behaviors and four health factors, with scores of 0-49 categorized as low CVH, 50-79 as moderate CVH, and 80-100 as high CVH. In the fully adjusted model, each one-point increase in the LE8 score corresponded to a 2.7, 2.7, and 1.6% decrease in all-cause, CVD, and cancer mortality risk, respectively, in people with MASLD. Compared to low CVH, being in moderate/high CVH was negatively associated with most mortality outcomes, while health factors lost significant association with cancer mortality.",
+ "PMID": "39382801",
+ "Title": "Drugs & aging",
+ "ArticleTitle": "Comment on \"The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia\".",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Middle Aged",
- "Prospective Studies",
- "Risk Factors",
- "Adult",
- "Aged",
+ "Dementia",
+ "Antipsychotic Agents",
"Cardiovascular Diseases",
- "Fatty Liver",
- "Cause of Death",
- "Metabolic Diseases",
- "Nutrition Surveys"
- ]
+ "Aged",
+ "Cerebrovascular Disorders",
+ "Nootropic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "9"
+ }
},
{
- "PMID": "39715477",
- "Title": "Neurology",
- "ArticleTitle": "Risk of Cardiovascular Diseases After Nonfocal Transient Neurologic Attacks in the Elderly: The Rotterdam Study.",
- "Abstract": "In this study, participants with nonfocal TNA did not have a subsequently elevated risk of CVD when compared with their matched counterparts, which contrasts with the elevated risk of stroke following a TIA. In the absence of other indications, initiating secondary prevention specifically after nonfocal TNA seems unwarranted.",
+ "PMID": "39374627",
+ "Title": "European heart journal",
+ "ArticleTitle": "Focus on the European Society of Cardiology: Guidelines on hypertension, Atlas of cardiovascular disease statistics, and Consensus statement on obesity.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Aged",
- "Ischemic Attack, Transient",
- "Middle Aged",
+ "Hypertension",
+ "Obesity",
+ "Europe",
"Cardiovascular Diseases",
- "Netherlands",
- "Cohort Studies",
- "Risk Factors",
- "Aged, 80 and over",
- "Stroke"
- ]
+ "Cardiology",
+ "Practice Guidelines as Topic",
+ "Societies, Medical",
+ "Consensus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
},
{
- "PMID": "39715341",
- "Title": "Endocrinology",
- "ArticleTitle": "GLP-1 and Its Analogs: Does Sex Matter?",
- "Abstract": "While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeutics, glucagon-like peptide 1 (GLP-1) analogs (eg, semaglutide), shows promise at curbing both diseases. This review addresses the topic of sex differences in the endogenous and therapeutic actions of GLP-1 and its analogs. Work on sex differences in human studies and animal research is reviewed. Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted. Moreover, recent clinical evidence of sex differences in the therapeutic effects of GLP-1 analogs in obesity, diabetes, and cardiovascular disease are discussed. Lastly, we review evidence for the role of GLP-1 analogs in mood and reproductive function, with particular attention to sex differences. Overall, while we did not find evidence for many qualitative sex differences in the therapeutic effect of clinically approved GLP-1 analogs, a growing body of literature highlights quantitative sex differences in the response to GLP-1 and its analogs as well as an interaction of these therapeutics with estrogens. What also clearly emerges is the paucity of data in female animal models or women in very basic aspects of the science of GLP-1-gaps that should be urgently mended, given the growing popularity of these medications, especially in women.",
+ "PMID": "39374023",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Insights Into Cardiovascular Risks of Chimeric Antigen Receptor T-Cell Therapy-From Peril to Promise.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Glucagon-Like Peptide 1",
- "Animals",
- "Female",
- "Male",
- "Sex Characteristics",
- "Obesity",
- "Glucagon-Like Peptides",
- "Hypoglycemic Agents",
- "Sex Factors",
+ "Receptors, Chimeric Antigen",
+ "Immunotherapy, Adoptive",
"Cardiovascular Diseases",
- "Diabetes Mellitus, Type 2"
- ]
+ "Receptors, Antigen, T-Cell"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39714500",
- "Title": "Giornale italiano di cardiologia (2006)",
- "ArticleTitle": "[Potassium role in the human body and clinical implications of hyperkalemia].",
- "Abstract": "Potassium is the most represented intracellular electrolyte in the human body. Its extracellular levels are maintained within strict limits through different mechanisms, which constitute the homeostasis of potassium. Hyperkalemia is the most common electrolyte disorder in patients with cardiovascular disease. Although with different levels of severity, it carries an increased risk of hospitalization, cardiovascular morbidity and mortality. Hyperkalemia may also be an important cause of discontinuation or impossibility of titration of fundamental therapies in the cardiology patient. The principal aim of this review is to analyze the mechanisms underlying hyperkalemia, as well as to summarize its epidemiology, risk factors, monitoring methodologies and electrophysiological and electrocardiographic effects, providing just only few essential elements of therapy. In this way the physician, and especially the cardiologist, can have an adequate knowledge for its management in clinical practice.",
+ "PMID": "39370167",
+ "Title": "Australian journal of general practice",
+ "ArticleTitle": "Inaccuracy of cardiovascular disease calculators in Australian primary healthcare software.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Hyperkalemia",
- "Potassium",
- "Risk Factors",
+ "Australia",
"Cardiovascular Diseases",
- "Electrocardiography"
- ]
+ "Primary Health Care",
+ "Software",
+ "Risk Assessment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39714498",
- "Title": "Giornale italiano di cardiologia (2006)",
- "ArticleTitle": "[Multidisciplinary and multiprofessional care to multimorbid chronic patients with cardiovascular disease: the experience of the Azienda Sanitaria Universitaria Giuliano Isontina].",
- "Abstract": "The world of chronic non-communicable diseases is progressively growing epidemiologically, requiring a significant commitment of resources, continuity of care, and strong integration between healthcare professionals and care settings. The National Recovery and Resilience Plan, in the Ministerial Decree 77 of 23/5/2022, identifies Community Homes as the privileged location for providing integrated, multidisciplinary and multiprofessional interventions, involving specialists and nursing clinics, general practitioners and district structures, utilizing all the necessary technological equipment, including digital platforms for telemedicine. In this context, cardiology is facing a complicated challenge: cardiologists must take care of patients with cardiovascular diseases who have also complex comorbidities and are required to extend their knowledge beyond the specific, sometimes super-specialistic, cardiovascular field, to avoid fragmentation, redundancy, and potential conflicts in the diagnostic-therapeutic care pathways. The Territorial Specialist Department, recently created in the Azienda Sanitaria Universitaria Giuliano Isontina, aims to promote the so-called \"value-based medicine\", that is, an effective yet sustainable medicine in both economic and social terms, reconciling guidelines with the actual needs of the patient. The ultimate goal is to implement an initiative-based medicine program with systematic stratification of patients at greater risk/complexity for a more efficient, appropriate and sustainable clinical governance.",
+ "PMID": "39367214",
+ "Title": "Nature cardiovascular research",
+ "ArticleTitle": "Semaglutide may reduce cardiovascular disease and heart failure.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Heart Failure",
+ "Glucagon-Like Peptides",
"Cardiovascular Diseases",
- "Patient Care Team",
- "Chronic Disease",
- "Italy",
- "Multimorbidity",
- "Telemedicine",
- "Cardiology"
- ]
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "5"
+ }
},
{
- "PMID": "39714021",
- "Title": "Journal of primary care & community health",
- "ArticleTitle": "Metabolic Syndrome: An Updated Review on Diagnosis and Treatment for Primary Care Clinicians.",
- "Abstract": "Metabolic syndrome is an independent risk factor for many poor health outcomes. Its individual components should be treated with medication and behavioral changes to reduce cardiovascular risk and prevent diabetes and its complications. More research is needed on how to treat the syndrome itself. A diagnosis of metabolic syndrome may be useful for motivating patients toward lifestyle changes, though more research is needed on how to treat the syndrome versus its components.",
+ "PMID": "39365849",
+ "Title": "JMIR medical informatics",
+ "ArticleTitle": "Practical Aspects of Using Large Language Models to Screen Abstracts for Cardiovascular Drug Development: Cross-Sectional Study.",
+ "Abstract": "Cardiovascular drug development requires synthesizing relevant literature about indications, mechanisms, biomarkers, and outcomes. This short study investigates the performance, cost, and prompt engineering trade-offs of 3 large language models accelerating the literature screening process for cardiovascular drug development applications.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
+ "Cross-Sectional Studies",
"Humans",
+ "Drug Development",
+ "Cardiovascular Agents",
+ "Abstracting and Indexing",
"Cardiovascular Diseases",
- "Exercise",
- "Life Style",
- "Metabolic Syndrome",
- "Primary Health Care",
- "Risk Factors",
- "Weight Loss"
- ]
+ "Natural Language Processing"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39713140",
- "Title": "PeerJ",
- "ArticleTitle": "Ferroptosis and its impact on common diseases.",
- "Abstract": "Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer's disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.",
+ "PMID": "39365620",
+ "Title": "Folia medica",
+ "ArticleTitle": "A case-control study investigating cardiovascular health in maintenance hemodialysis patients through oxidative stress biomarkers and carotid artery intima-media thickness.",
+ "Abstract": "Chronic kidney disease (CKD) is a major risk factor for the development of cardiovascular disease (CVD), and it is the leading cause of morbidity and mortality in end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (MHD).",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
- "Ferroptosis",
"Humans",
- "Neoplasms",
- "Lipid Peroxidation",
- "Reperfusion Injury",
- "Cardiovascular Diseases",
- "Inflammatory Bowel Diseases",
- "Alzheimer Disease",
- "Iron",
- "Acute Kidney Injury",
- "Stroke",
- "Animals"
- ]
+ "Renal Dialysis",
+ "Carotid Intima-Media Thickness",
+ "Oxidative Stress",
+ "Case-Control Studies",
+ "Male",
+ "Female",
+ "Biomarkers",
+ "Middle Aged",
+ "Kidney Failure, Chronic",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Adult",
+ "Renal Insufficiency, Chronic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39712314",
- "Title": "Frontiers in public health",
- "ArticleTitle": "The impact of meteorological conditions on cardiovascular and cerebrovascular diseases in different microclimatic zones of low-latitude mountainous areas.",
- "Abstract": "Our findings delineated the common characteristics of the effect on the incidence of CVD of meteorological environments in various microclimate zones, and clarified the influence of minimum temperature and TCN exhibited spatial heterogeneity, Which may be assistance for meteorological risk forecasting in CVD prevention and control.",
+ "PMID": "39364572",
+ "Title": "European heart journal. Cardiovascular pharmacotherapy",
+ "ArticleTitle": "Focus on different lipid-lowering treatment and genetic testing for optimal pharmacotherapy use in the clinic.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
+ "Hypolipidemic Agents",
+ "Dyslipidemias",
+ "Pharmacogenomic Testing",
+ "Treatment Outcome",
"Cardiovascular Diseases",
- "Incidence",
- "Microclimate",
- "China",
- "Cerebrovascular Disorders",
- "Meteorological Concepts",
- "Temperature",
- "Risk Factors"
- ]
+ "Lipids",
+ "Pharmacogenomic Variants",
+ "Predictive Value of Tests",
+ "Genetic Testing",
+ "Pharmacogenetics",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Clinical Decision-Making",
+ "Precision Medicine"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39711839",
- "Title": "The Pan African medical journal",
- "ArticleTitle": "An audit of the establishment of a cardiac magnetic resonance imaging service in a public tertiary hospital setting in the Western Cape Province of South Africa.",
- "Abstract": "the recently established, functional cardiovascular magnetic resonance imaging service at Tygerberg Hospital serves a unique patient population with a comparatively differently distributed cardiac disease spectrum, contributing to research diversity.",
+ "PMID": "39357943",
+ "Title": "Journal of the American College of Cardiology",
+ "ArticleTitle": "Embracing Change: Human-Centered Cardiovascular Medicine in the Era of AI.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Female",
- "South Africa",
- "Tertiary Care Centers",
- "Retrospective Studies",
- "Adult",
- "Male",
- "Middle Aged",
- "Magnetic Resonance Imaging",
- "Young Adult",
- "Aged",
- "Cardiovascular Diseases",
- "Adolescent",
- "Hospitals, Public",
- "Contrast Media",
- "Aged, 80 and over",
- "Heart Diseases",
- "Child",
- "Child, Preschool",
- "Medical Audit"
- ]
+ "Cardiology",
+ "Artificial Intelligence",
+ "Patient-Centered Care",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39710789",
- "Title": "European journal of medical research",
- "ArticleTitle": "Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease.",
- "Abstract": "The gut microbiota is a complex and dynamic ecosystem that plays a crucial role in human health and disease, including obesity, diabetes, cardiovascular diseases, neurodegenerative diseases, inflammatory bowel disease, and cancer. Chronic inflammation is a common feature of these diseases and is closely related to angiogenesis (the process of forming new blood vessels), which is often dysregulated in pathological conditions. Inflammation potentially acts as a central mediator. This abstract aims to elucidate the connection between the gut microbiota and angiogenesis in various diseases. The gut microbiota influences angiogenesis through various mechanisms, including the production of metabolites that directly or indirectly affect vascularization. For example, short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate are known to regulate immune responses and inflammation, thereby affecting angiogenesis. In the context of cardiovascular diseases, the gut microbiota promotes atherosclerosis and vascular dysfunction by producing trimethylamine N-oxide (TMAO) and other metabolites that promote inflammation and endothelial dysfunction. Similarly, in neurodegenerative diseases, the gut microbiota may influence neuroinflammation and the integrity of the blood-brain barrier, thereby affecting angiogenesis. In cases of fractures and wound healing, the gut microbiota promotes angiogenesis by activating inflammatory responses and immune effects, facilitating the healing of tissue damage. In cancer, the gut microbiota can either inhibit or promote tumor growth and angiogenesis, depending on the specific bacterial composition and their metabolites. For instance, some bacteria can activate inflammasomes, leading to the production of inflammatory factors that alter the tumor immune microenvironment and activate angiogenesis-related signaling pathways, affecting tumor angiogenesis and metastasis. Some bacteria can directly interact with tumor cells, activating angiogenesis-related signaling pathways. Diet, as a modifiable factor, significantly influences angiogenesis through diet-derived microbial metabolites. Diet can rapidly alter the composition of the microbiota and its metabolic activity, thereby changing the concentration of microbial-derived metabolites and profoundly affecting the host's immune response and angiogenesis. For example, a high animal protein diet promotes the production of pro-atherogenic metabolites like TMAO, activating inflammatory pathways and interfering with platelet function, which is associated with the severity of coronary artery plaques, peripheral artery disease, and cardiovascular diseases. A diet rich in dietary fiber promotes the production of SCFAs, which act as ligands for cell surface or intracellular receptors, regulating various biological processes, including inflammation, tissue homeostasis, and immune responses, thereby influencing angiogenesis. In summary, the role of the gut microbiota in angiogenesis is multifaceted, playing an important role in disease progression by affecting various biological processes such as inflammation, immune responses, and multiple signaling pathways. Diet-derived microbial metabolites play a crucial role in linking the gut microbiota and angiogenesis. Understanding the complex interactions between diet, the gut microbiota, and angiogenesis has the potential to uncover novel therapeutic targets for managing these conditions. Therefore, interventions targeting the gut microbiota and its metabolites, such as through fecal microbiota transplantation (FMT) and the application of probiotics to alter the composition of the gut microbiota and enhance the production of beneficial metabolites, present a promising therapeutic strategy.",
+ "PMID": "39356811",
+ "Title": "Clinical advances in hematology & oncology : H&O",
+ "ArticleTitle": "The global cardio-oncology registry.",
+ "Abstract": "",
"Predictions": [
"Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Gastrointestinal Microbiome",
- "Neovascularization, Pathologic",
- "Neoplasms",
- "Inflammation",
+ "Cardio-Oncology",
"Cardiovascular Diseases",
- "Animals",
- "Neurodegenerative Diseases",
- "Angiogenesis"
- ]
+ "Medical Oncology",
+ "Neoplasms",
+ "Registries"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "2"
+ }
},
{
- "PMID": "39710702",
- "Title": "Journal of translational medicine",
- "ArticleTitle": "Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer.",
- "Abstract": "The identification of ferroptosis represents a pivotal advancement in the field of cell death research, revealing an entirely novel mechanism of cellular demise and offering new insights into the initiation, progression, and therapeutic management of various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments in the antioxidant defense system, culminating in membrane rupture and consequent cell death. Studies have associated ferroptosis with a wide range of diseases, and by enhancing our comprehension of its underlying mechanisms, we can formulate innovative therapeutic strategies, thereby providing renewed hope for patients.",
+ "PMID": "39349033",
+ "Title": "Clinics in geriatric medicine",
+ "ArticleTitle": "Optimal Blood Pressure Targets with Age.",
+ "Abstract": "The focus of antihypertensive therapy in older adults should be on lowering the systolic blood pressure (SBP) to the patient's \"optimal\" benefit-based target goal. Applying benefit-based therapy to the majority of adults aged 65\u00a0years or older who are at high cardiovascular disease or cognitive impairment risk favors an SBP goal of less than 130\u00a0mm Hg, and for some, a goal of 120\u00a0mm Hg may be considered.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases"
],
"MeshTerms": [
- "Ferroptosis",
"Humans",
- "Neurodegenerative Diseases",
+ "Antihypertensive Agents",
+ "Aged",
+ "Hypertension",
+ "Blood Pressure",
+ "Aging",
"Cardiovascular Diseases",
- "Neoplasms",
- "Animals",
- "Molecular Targeted Therapy"
- ]
+ "Age Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "1"
+ }
},
{
- "PMID": "39710576",
- "Title": "Gut microbes",
- "ArticleTitle": "Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project.",
- "Abstract": "The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy's impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2\u2009months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, ",
+ "PMID": "39347730",
+ "Title": "Journal of cardiovascular medicine (Hagerstown, Md.)",
+ "ArticleTitle": "Serum uric acid level and risk of cardiovascular mortality and chronic kidney disease.",
+ "Abstract": "",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Gastrointestinal Microbiome",
+ "Uric Acid",
+ "Renal Insufficiency, Chronic",
+ "Cardiovascular Diseases",
+ "Biomarkers",
"Male",
+ "Hyperuricemia",
"Female",
+ "Risk Factors",
"Middle Aged",
- "Adult",
- "Cross-Over Studies",
- "Inflammation",
- "Endotoxemia",
- "Cardiovascular Diseases",
- "Cardiometabolic Risk Factors",
- "Diet",
- "Polyphenols",
- "Edible Grain",
- "Feces",
- "Bacteria",
- "Fatty Acids, Omega-3",
- "Dietary Fiber",
- "Intestines"
- ]
+ "Aged",
+ "Heart Disease Risk Factors",
+ "Risk Assessment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "30"
+ }
},
{
- "PMID": "39710465",
- "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
- "ArticleTitle": "[The correlation between allergic diseases and cardiovascular disease incidence].",
- "Abstract": "Allergic reactions are abnormal responses of the immune system to specific allergens, typically resulting in the release of inflammatory mediators and tissue damage. Cardiovascular diseases are common conditions that contribute significantly to increased mortality rates, with inflammation-induced tissue damage playing a crucial role in their pathogenesis. Allergic reactions are associated with various aspects of cardiovascular diseases, such as hypertension, atherosclerosis, and cardiac remodeling. Certain allergic conditions may increase the risk of cardiovascular disease onset. This article aims to explore the role of inflammatory mediators in allergic reactions within the pathophysiology of common cardiovascular diseases. By doing so, it seeks to uncover potential links between allergic reactions and cardiovascular diseases, offering new insights for the prevention and treatment of related conditions.",
+ "PMID": "39299858",
+ "Title": "Trends in endocrinology and metabolism: TEM",
+ "ArticleTitle": "Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum.",
+ "Abstract": "Physiological changes during pregnancy may predict future cardiovascular and metabolic diseases; thus, identifying mechanisms driving cardiometabolic impairments, as well as potential interventions to improve health during pregnancy, is crucial. We discuss how sleep and circadian disruption during pregnancy and postpartum affect cardiometabolic risk, and identify future research directions.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Cardiovascular Diseases",
- "Hypersensitivity",
- "Incidence"
- ]
+ "Pregnancy",
+ "Female",
+ "Postpartum Period",
+ "Sleep",
+ "Circadian Rhythm",
+ "Metabolic Diseases",
+ "Pregnancy Complications",
+ "Sleep Wake Disorders",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "20"
+ }
},
{
- "PMID": "39709856",
- "Title": "Health & place",
- "ArticleTitle": "Association between ambient temperatures and cardiovascular disease: A time series analysis using emergency ambulance dispatches in Chongqing, China, 2019-2021.",
- "Abstract": "Ambient temperature is significantly associated with the risk of CVD, with elderly patients, especially females, being a high-risk subgroup. Governments need to formulate localized health policies that address regional climate patterns and population vulnerabilities. As one of the famous \"Furnace Cities\", Chongqing's measures for coping with hot environments can serve as a reference. Nonetheless, improving our understanding and preparation for cold weather is also crucial. Public warning systems should be improved, and local heating strategies for vulnerable groups should be developed to minimize the negative risk of extreme cold temperatures to the public.",
+ "PMID": "39262185",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[The 2024 landscape of aldosterone blockade].",
+ "Abstract": "Aldosterone is a steroid hormone playing a key role in arterial hypertension physiopathology. In case of inappropriate secretion, it has a detrimental action on the kidney and cardiovascular system and therefore constitutes an interesting therapeutic target for several diseases. Recent progress allowed to expand the therapeutic arsenal for physician practitioner and new promising drugs will probably appear on the market the next few years. Hence, physicians should know the indications and side effects of these new treatments.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Cardiovascular Diseases",
- "Male",
- "Female",
- "China",
- "Middle Aged",
- "Ambulances",
- "Aged",
- "Adult",
- "Emergency Medical Dispatch",
- "Temperature",
- "Incidence",
- "Adolescent",
- "Child"
- ]
+ "Mineralocorticoid Receptor Antagonists",
+ "Aldosterone",
+ "Hypertension",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "12"
+ }
},
{
- "PMID": "39709670",
- "Title": "European journal of cancer (Oxford, England : 1990)",
- "ArticleTitle": "Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors.",
- "Abstract": "GLP1a use in cancer patients with T2DM receiving ICIs was associated with reduced MACE and all-cause mortality without an increased risk in serious adverse events.",
+ "PMID": "39248635",
+ "Title": "Exercise and sport sciences reviews",
+ "ArticleTitle": "Impact of Religion-Based Mindful Walking Meditation on Cardiometabolic and Mental Health.",
+ "Abstract": "Walking meditation or mindful walking is a widely performed form of Buddhist practice that focuses on mind-body interactions. We have found that this particular form of exercise was highly effective in eliciting improvements in cardiometabolic and functional fitness measures in a number of clinical populations. In some key measures, the magnitudes of benefits were greater than the traditional walking program.",
"Predictions": [
- "Cancer",
"Cardiovascular diseases",
- "Diabetes type 2"
+ "Mental Health"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Immune Checkpoint Inhibitors",
- "Retrospective Studies",
- "Neoplasms",
- "Aged",
- "Middle Aged",
- "Cardiovascular Diseases",
- "Glucagon-Like Peptide 1",
- "Diabetes Mellitus, Type 2"
- ]
+ "Meditation",
+ "Walking",
+ "Mental Health",
+ "Buddhism",
+ "Mindfulness",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "9"
+ }
},
{
- "PMID": "39709650",
- "Title": "Clinical nutrition (Edinburgh, Scotland)",
- "ArticleTitle": "Stearic acid metabolism in human health and disease.",
- "Abstract": "Named after the Greek term for \"hard fat\", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis. Similar to palmitate, stearic acid serves as a primary substrate for the stearoyl coenzyme A desaturase, which catalyzes the conversion of stearate to oleate and is involved in the synthesis of triglyceride and other complex lipids. Additionally, stearic acid functions as a vital signaling molecule in pathological processes such as cardiovascular diseases, diabetes development, liver injury and even nervous system disorders. Therefore, we conduct a comprehensive review of stearic acid, summarizing its role in various diseases and attempting to provide a systematic overview of its homeostasis, physiological functions, and pathological process. From a medical standpoint, we also explore potential applications and discuss stearic acid as a potential therapeutic target for the treatment of human diseases.",
+ "PMID": "39214527",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Tackling social and behavioural risk factors for cardiovascular diseases in Chinese women.",
+ "Abstract": "Chinese women have benefited more than men from improvements in social determinants of health in decreasing the burden of cardiovascular diseases in recent decades; however, Chinese women, especially those in the younger generation, are facing new challenges, argue",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
+ "Female",
"Cardiovascular Diseases",
- "Energy Metabolism",
- "Lipid Metabolism",
- "Signal Transduction",
- "Stearic Acids",
- "Stearoyl-CoA Desaturase"
- ]
+ "China",
+ "Risk Factors",
+ "Heart Disease Risk Factors",
+ "Health Behavior",
+ "East Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39709627",
- "Title": "Expert opinion on pharmacotherapy",
- "ArticleTitle": "Advances in the pharmacological management of hyperlipidemia through the use of combination therapies.",
- "Abstract": "Combination therapy for LDL-C in dual combinations is well validated. Data for intervention on triglycerides is limited to icosapent ethyl, but this may exert effects independent of lipids. New drugs targeting triglycerides through apolipoprotein C3 and angiopoietin-like peptides are in development. Studies on combination therapy raising HDL-C have generally disappointed, though cholesterol ester transfer protein (CETP) inhibition remains a target. Lipoprotein (a) is recognized as a CVD risk factor and effective therapies are in development but results on CVD events are lacking.",
+ "PMID": "39189095",
+ "Title": "Journal of medicinal food",
+ "ArticleTitle": "Is Cottonseed Oil the Next Healthy Oil?",
+ "Abstract": "Cotton is primarily recognized as a textile crop; however, recent evidence suggests that cottonseed oil (CSO) may be a simple and effective dietary approach to improving cardiometabolic risk factors. The purpose of this perspective is to draw attention to the current literature examining the physiological benefits of CSO consumption and highlight the remaining questions that need to be answered to fully evaluate the potential of CSO to be the next important nutrition intervention for improving cardiometabolic health.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Drug Therapy, Combination",
- "Hyperlipidemias",
- "Hypolipidemic Agents",
- "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Cardiometabolic Risk Factors",
"Cardiovascular Diseases",
- "Cholesterol, LDL",
- "Animals",
- "Triglycerides"
- ]
+ "Cottonseed Oil",
+ "Gossypium"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "27"
+ }
},
{
- "PMID": "39709554",
- "Title": "Gut microbes",
- "ArticleTitle": "Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.",
- "Abstract": "The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained\u2009<\u200910% of the proteome variance. However, unsupervised human protein-based clustering analysis revealed two distinct CVD risk clusters (low-risk and high-risk) with different blood pressure (by 9\u2009mmHg) and sex-dependent dietary potassium and fiber intake. In the human proteome, the low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated with neutrophil extracellular trap formation and auto-immune diseases. In the microbial proteome, the low-risk group had higher expression of phosphate acetyltransferase that produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes in heart failure patients and long-term risk of cardiovascular events in a large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms that may underlie risk factors for CVD.",
+ "PMID": "39181403",
+ "Title": "Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance",
+ "ArticleTitle": "Society for Cardiovascular Magnetic Resonance 2023 Cases of SCMR case series.",
+ "Abstract": "\"Cases of SCMR\" is a case series on the SCMR website (https://www.scmr.org) for the purpose of education. The cases reflect the clinical presentation and the use of cardiovascular magnetic resonance in the diagnosis and management of cardiovascular disease. The 2023 digital collection of cases is presented in this article.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
+ "Adult",
+ "Aged",
+ "Female",
"Humans",
- "Feces",
- "Gastrointestinal Microbiome",
"Male",
- "Female",
- "Proteomics",
"Middle Aged",
- "Heart Failure",
+ "Young Adult",
"Cardiovascular Diseases",
- "Aged",
- "Adult",
- "Proteome",
- "Bacteria",
- "Risk Factors",
- "Diet"
- ]
+ "Magnetic Resonance Imaging",
+ "Predictive Value of Tests",
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "26"
+ }
},
{
- "PMID": "39709470",
- "Title": "Cardiovascular diabetology",
- "ArticleTitle": "Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.",
- "Abstract": "Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated with widespread vascular disease affecting both the kidney and the heart from an early stage. However, the risk of diabetic nephropathy in people with type 1 diabetes is strongly genetically determined, as documented in familial transmission studies. The search for the underlying genes has been extensive, using specific hypotheses, sibling linkage studies and genome-wide association studies (GWAS). The role of the angiotensinI-converting enzyme/kininase II (ACE) gene and genetic variability in ACE levels as a susceptibility and prognostic factor for diabetic nephropathy has been well documented in people with type 1 diabetes. The ACE gene insertion/deletion polymorphism, which is associated with plasma and tissue ACE levels, has been the most studied genomic variant in diabetic nephropathy. Recently, this polymorphism has also been associated with longevity in people with type 1 diabetes. The ACE I/D polymorphism has also been associated with vascular, extra-renal complications including myocardial infarction and lower-limb amputation in this population. Other genes and loci have been identified in linkage studies and GWAS, such as the COL4A3 gene or a region on chromosome 3q with the adiponectin gene. Replication was not always attempted and was rarely achieved, even for GWAS. Overall, effect sizes remain modest and no major gene has been identified, despite the strength of the genetic effect in transmission studies. We searched bibliographic databases for studies reporting genomic variants associated with diabetic nephropathy and meta-analyses of such studies. We selected important relevant studies for further discussion in this narrative review. This brief review attempts to summarise the current knowledge on the genetics of diabetic nephropathy and associated cardiovascular disease in people with type 1 diabetes, and discusses some conceptual and methodological issues relevant to the interpretation of past studies and the design of future ones.",
+ "PMID": "39150532",
+ "Title": "Food & function",
+ "ArticleTitle": "Comment on \"Olive oil intake and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies\" by Y. Ke, H. Fan, Y. Zhao, X. Fu, M. Wang, Y. Gao, Y. Chen, W. Huo, W. Zhang, L. Wang, Y. Wu, X. Li, D. Zhang, F. Hu, M. Zhang, L. Sun, J. Lu and D. Hu, , 2024, D3FO05246J.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 1"
+ "Cancer",
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Genetic Predisposition to Disease",
- "Diabetic Nephropathies",
- "Diabetes Mellitus, Type 1",
- "Peptidyl-Dipeptidase A",
"Cardiovascular Diseases",
- "Phenotype",
- "Genome-Wide Association Study",
- "Risk Factors",
- "Polymorphism, Genetic"
- ]
+ "Neoplasms",
+ "Prospective Studies",
+ "Meta-Analysis as Topic",
+ "Systematic Reviews as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "16"
+ }
},
{
- "PMID": "39709437",
- "Title": "Cardiovascular diabetology",
- "ArticleTitle": "Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation.",
- "Abstract": "A high level potassium intake estimated from urine potassium excretion was independently associated with a low risk of MACE in patients with type 2 diabetes. Increasing potassium intake may be a potential effective strategy for cardiovascular risk reduction beyond controlling traditional risk factors.",
+ "PMID": "39122600",
+ "Title": "Trends in endocrinology and metabolism: TEM",
+ "ArticleTitle": "Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases.",
+ "Abstract": "Microplastics and nanoplastics (MNPs) are being recognized as new cardiovascular risk factors, impacting vascular cell functions and exacerbating atherosclerosis through diverse mechanisms. However, the varied concentrations of MNPs detected in major cardiovascular tissues highlight the urgent need for standardized research methodologies to better understand their impact and inform future health guidelines.",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 2",
- "Female",
- "Male",
- "Prospective Studies",
- "Middle Aged",
- "Risk Assessment",
- "Aged",
- "Time Factors",
- "Potassium, Dietary",
+ "Microplastics",
"Cardiovascular Diseases",
- "Reproducibility of Results",
- "Prognosis",
- "Biomarkers",
- "Risk Factors",
- "Protective Factors",
- "Albuminuria",
- "Urinalysis",
- "Recommended Dietary Allowances"
- ]
+ "Nanoparticles",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "10"
+ }
},
{
- "PMID": "39709369",
- "Title": "BMC pulmonary medicine",
- "ArticleTitle": "Relationship between systemic immune-inflammation index and long-term all-cause and cause-specific mortality among adult asthma patients: a population-based study.",
- "Abstract": "Clinical trial number not applicable.",
+ "PMID": "39059364",
+ "Title": "Cell",
+ "ArticleTitle": "Translating metabolic and cardiovascular research into effective treatments: What's next?",
+ "Abstract": "The future of healthcare for cardiovascular diseases holds immense promise, not only based in new discoveries in cardiac metabolism but also in translating them to solutions for critical challenges faced by society. Here, ten scientists share their insights, shedding light on the future that lies ahead for this field.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Asthma",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Nutrition Surveys",
- "Inflammation",
- "Cause of Death",
"Cardiovascular Diseases",
- "Aged",
- "United States",
- "Proportional Hazards Models",
- "Kaplan-Meier Estimate",
- "Risk Factors"
- ]
+ "Translational Research, Biomedical",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "27"
+ }
},
{
- "PMID": "39709364",
- "Title": "BMC surgery",
- "ArticleTitle": "Development of a predictive model for postoperative major adverse cardiovascular events in elderly patients undergoing major abdominal surgery.",
- "Abstract": "The nomogram risk prediction model based on SPPB and clinical indicators can better predict the occurrence of MACEs and can guide preoperative intervention and help to improve perioperative management.",
+ "PMID": "39000153",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Apolipoproteins in Health and Disease.",
+ "Abstract": "Although apolipoproteins (apo) were initially acknowledged as major determinants in lipoprotein metabolism and cardiovascular disease, the findings of recent studies have revealed the significance of multiple apolipoprotein classes and subclasses in various biological processes and pathophysiological pathways [...].",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Aged",
- "Female",
- "Male",
- "Postoperative Complications",
+ "Apolipoproteins",
"Cardiovascular Diseases",
- "Abdomen",
- "Risk Assessment",
- "Nomograms",
- "Retrospective Studies",
- "Aged, 80 and over",
- "Risk Factors",
- "Predictive Value of Tests",
- "ROC Curve",
- "Incidence"
- ]
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "13"
+ }
},
{
- "PMID": "39709110",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes.",
- "Abstract": "Higher eGDR level was associated with lower risks of all-cause and cardiovascular deaths in a linear dose-response manner among non-diabetic females, while L-shaped relationships were observed among non-diabetic males.",
+ "PMID": "38944190",
+ "Title": "The Journal of pediatrics",
+ "ArticleTitle": "American Academy of Pediatrics Recommended Cardiac Screening Questions in Preparticipation Physical Evaluation Forms.",
+ "Abstract": "To evaluate the utilization of the American Academy of Pediatrics' (AAP) cardiovascular screening questions within preparticipation physical evaluation forms from the 50 state high school athletic associations. We found that fewer than one-half of state forms incorporated all 10 AAP questions; moreover, a subset failed to adhere to criteria recommended by either the AAP or American Heart Association.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Insulin Resistance",
- "Adult",
- "Blood Glucose",
- "Nutrition Surveys",
- "Sex Factors",
- "Risk Factors",
- "Cause of Death",
- "Aged"
- ]
+ "United States",
+ "Physical Examination",
+ "Pediatrics",
+ "Mass Screening",
+ "Societies, Medical",
+ "Adolescent",
+ "American Heart Association",
+ "Practice Guidelines as Topic",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "30"
+ }
},
{
- "PMID": "39708996",
- "Title": "Preventive medicine",
- "ArticleTitle": "Association between physical activity-related metabolic signature and cardiometabolic diseases and multimorbidity: A cohort study from UK biobank.",
- "Abstract": "Physical activity-related metabolic signature is linked to reduced risks of CMDs and CMM. We once again emphasize the importance of physical activity for CMDs prevention from a metabolic perspective, especially for individuals at high genetic risk.",
+ "PMID": "38938760",
+ "Title": "North Carolina medical journal",
+ "ArticleTitle": "Advancing Cardiovascular Risk Assessment with Artificial Intelligence: Opportunities and Implications in North Carolina.",
+ "Abstract": "Cardiovascular disease mortality is increasing in North Carolina with persistent inequality by race, income, and location. Artificial intelligence (AI) can repurpose the widely available electrocardiogram (ECG) for enhanced assessment of cardiac dysfunction. By identifying accelerated cardiac aging from the ECG, AI offers novel insights into risk assessment and prevention.",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "United Kingdom",
- "Female",
- "Male",
- "Exercise",
- "Middle Aged",
- "Prospective Studies",
- "Multimorbidity",
- "Diabetes Mellitus, Type 2",
- "Aged",
+ "North Carolina",
+ "Artificial Intelligence",
"Cardiovascular Diseases",
- "Biological Specimen Banks",
- "Coronary Disease",
- "Genetic Predisposition to Disease",
- "Stroke",
- "Adult",
- "UK Biobank"
- ]
+ "Risk Assessment",
+ "Electrocardiography"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "28"
+ }
},
{
- "PMID": "39708590",
- "Title": "Maturitas",
- "ArticleTitle": "Obstructive sleep apnea syndrome (OSAS) in women: A forgotten cardiovascular risk factor.",
- "Abstract": "Sleep-disordered breathing is a highly prevalent disorder with negative impact on healthcare systems worldwide. This condition has detrimental effects on cardiovascular health and quality of life, and is frequently associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes and atrial fibrillation. Nevertheless, it remains frequently undiagnosed and undertreated, especially in specific populations. Studies on sleep-disordered breathing have been conducted mainly on male patients, and the prevalence and severity of this disorder in women are underestimated. Recently, some clinical and laboratory evidence has highlighted the epidemiological and pathophysiological differences between men and women with sleep-disordered breathing. In this review, we discuss sex-related mechanisms of sleep-disordered breathing in frequently associated disorders, to improve clinical understanding of this condition and to simplify the practical application of targeted interventions. The aim is to improve prognosis among female patients and guarantee a better quality of life and a reduction in healthcare costs.",
+ "PMID": "38895785",
+ "Title": "Revista espanola de enfermedades digestivas",
+ "ArticleTitle": "Cohorte Cantabria - A biomedical research tool open to the world.",
+ "Abstract": "The contribution of large population-based study cohorts to the knowledge of disease risk factors and causes is unquestionable. The Framingham Cohort, a paradigm for the population-based studies that changed the history of medicine, emerged after the antibiotic revolution, the decrease in infection-related mortality, and the boom in cardiovascular morbidity and mortality.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Female",
- "Sleep Apnea, Obstructive",
+ "Biomedical Research",
+ "Cohort Studies",
"Cardiovascular Diseases",
- "Quality of Life",
- "Heart Disease Risk Factors",
- "Sex Factors",
- "Risk Factors",
- "Prevalence",
- "Male"
- ]
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "19"
+ }
},
{
- "PMID": "39708140",
- "Title": "Rheumatology international",
- "ArticleTitle": "Prevalence of comorbidities and cardiovascular risk factor management in hand osteoarthritis: a cross-sectional study.",
- "Abstract": "We found an increased CV risk in hand osteoarthritis patients who had an insufficient LDL cholesterol target achievement. Hand osteoarthritis patients appear to have a pro-atherogenic profile. These results suggest that CV risk factors should be assessed in patients with hand osteoarthritis and managed according to recommended guidelines.",
+ "PMID": "38892029",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Molecular Aspects of Cardiometabolic Diseases: From Etiopathogenesis to Potential Therapeutic Targets.",
+ "Abstract": "Cardiometabolic diseases (CMDs) encompass a range of prevalent, often preventable, non-communicable illnesses, including myocardial infarction, stroke, cardiac insufficiency, arterial hypertension, obesity, type 2 diabetes mellitus, insulin resistance, chronic renal dysfunction, non-alcoholic fatty liver disease, and rare metabolic disorders [...].",
"Predictions": [
- "Cardiovascular diseases"
+ "Cardiovascular diseases",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Male",
- "Cross-Sectional Studies",
- "Female",
- "Osteoarthritis",
- "Middle Aged",
- "Aged",
- "Heart Disease Risk Factors",
- "Prevalence",
- "Hand Joints",
- "Comorbidity",
"Cardiovascular Diseases",
- "Hand Strength",
- "Quality of Life",
- "Risk Factors",
- "Hydroxymethylglutaryl-CoA Reductase Inhibitors"
- ]
+ "Metabolic Diseases",
+ "Diabetes Mellitus, Type 2",
+ "Animals",
+ "Insulin Resistance",
+ "Obesity"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "19"
+ }
},
{
- "PMID": "39707266",
- "Title": "BMC pulmonary medicine",
- "ArticleTitle": "Effectiveness of high-intensity inspiratory muscle training, and resistance and aerobic exercise for cardiovascular health in chronic obstructive pulmonary disease (HIRAC-COPD): a randomized controlled trial protocol.",
- "Abstract": "ChiCTR2400085483. Date of registration: June 7, 2024. https://www.chictr.org.cn/index.aspx .",
+ "PMID": "38871571",
+ "Title": "Infectious disease clinics of North America",
+ "ArticleTitle": "Advances in the Management of Cardiovascular Disease in the Setting of Human Immunodeficiency Virus.",
+ "Abstract": "This state-of-the art review discusses the underlying mechanisms that contribute to atherosclerotic cardiovascular disease, heart failure and arrhythmias among people with human immunodeficiency virus (HIV), risk prediction and prevention, management, and outstanding research questions, including a discussion of how the Randomized Trial to Prevent Vascular Events in HIV may inform clinical practice.",
"Predictions": [
"Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Pulmonary Disease, Chronic Obstructive",
- "Vascular Stiffness",
- "Breathing Exercises",
- "Randomized Controlled Trials as Topic",
- "Pulse Wave Analysis",
- "Resistance Training",
+ "HIV Infections",
"Cardiovascular Diseases",
- "Exercise",
- "Quality of Life",
- "Respiratory Muscles",
- "Aged",
- "Ankle Brachial Index",
- "Male",
- "Exercise Therapy",
- "Middle Aged"
- ]
+ "Risk Factors",
+ "Disease Management"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "14"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/chronic_respiratory_disease.json b/testModel/dataset/chronic_respiratory_disease.json
index 168afb692..7053ceabc 100644
--- a/testModel/dataset/chronic_respiratory_disease.json
+++ b/testModel/dataset/chronic_respiratory_disease.json
@@ -3,7 +3,7 @@
"PMID": "39738021",
"Title": "Nature communications",
"ArticleTitle": "Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.",
- "Abstract": "Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China. An integrated exposure-response model was used to estimate the association between OP and EPFRs and hospitalization during SDS. EPFRs were strongly associated with circulatory (3.05%; 95% confidence interval [CI]: 1.01%, 4.08%) and respiratory (2.02%; 95% CI: 1.01%, 4.08%) diseases with each increase of 10",
+ "Abstract": "Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China. An integrated exposure-response model was used to estimate the association between OP and EPFRs and hospitalization during SDS. EPFRs were strongly associated with circulatory (3.05%; 95% confidence interval [CI]: 1.01%, 4.08%) and respiratory (2.02%; 95% CI: 1.01%, 4.08%) diseases with each increase of 10 spins/m. The OP effects on circulatory (3.52%; 95% CI: 2.13%, 4.92%) and respiratory diseases (2.08%; 95% CI: 1.13%, 3.04%) with each increase of 0.2\u2009nmol/min/m were also statistically significant. Additionally, 20.47% and 27.26% of all-cause hospitalizations were attributable to OP and EPFRs exposure, respectively. This knowledge could be used to develop effective sand and dust risk prevention in dust-prone countries.",
"Predictions": [
"Chronic respiratory disease",
"Cardiovascular diseases"
@@ -23,13 +23,18 @@
"Respiratory Tract Diseases",
"Oxidation-Reduction",
"Cardiovascular Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39729927",
"Title": "Cancer genetics",
"ArticleTitle": "Machine learning analysis of CD4+ T cell gene expression in diverse diseases: insights from cancer, metabolic, respiratory, and digestive disorders.",
- "Abstract": "CD4",
+ "Abstract": "CD4 T cells play a pivotal role in the immune system, particularly in adaptive immunity, by orchestrating and enhancing immune responses. CD4 T cell-related immune responses exhibit diverse characteristics in different diseases. This study utilizes gene expression analysis of CD4 T cells to classify and understand complex diseases. We analyzed the dataset consisting of samples from various diseases, including cancers, metabolic disorders, circulatory and respiratory diseases, and digestive ailments, as well as 53 healthy controls. Each sample contained expression data for 22,881 genes. Four feature ranking algorithms, incremental feature selection method, synthetic minority oversampling technique, and four classification algorithms were utilized to pinpoint essential genes, extract classification rules and build efficient classifiers. The following analysis focused on genes across rules, such as AK4, CALU, LINC01271, and RUSC1-AS1. AK4 and CALU show fluctuating levels in diseases like asthma, Crohn's disease, and breast cancer. The analysis results and existing research suggest that they may play a role in these diseases. LINC01271 generally has higher expression in conditions including asthma, Crohn's disease, and diabetes. RUSC1-AS1 is more expressed in chronic diseases like asthma and Crohn's, but less in acute illnesses like tonsillitis and influenza. This highlights the distinct roles of these genes in different diseases. Our approach highlights the potential for developing novel therapeutic strategies based on the transcriptional profiles of CD4 T cells.",
"Predictions": [
"Cancer",
"Chronic respiratory disease"
@@ -44,7 +49,12 @@
"Respiratory Tract Diseases",
"Gene Expression Profiling",
"Respiration Disorders"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39729438",
@@ -60,13 +70,66 @@
"Respiratory Tract Diseases",
"Telemedicine",
"Scoping Reviews As Topic"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39729055",
+ "Title": "Journal of the American Dental Association (1939)",
+ "ArticleTitle": "Nonmalignant respiratory disease mortality among dentists in the United States from 1979 through 2018.",
+ "Abstract": "Dentists can be exposed to dust and nanoparticles from teeth, dental composites, and metal alloys generated during dental procedures, and exposure to dust can cause respiratory diseases, including pulmonary fibrosis. The authors describe mortality from nonmalignant respiratory diseases (NMRDs) among dentists in the United States.The authors submitted information on US dentists who died from 1979 through 2018 to a centralized US death records database to obtain underlying causes of death. Decedent data that met records-matching criteria were analyzed using the Life Table\u00a0Analysis System software (National Institute for Occupational Safety and Health) to calculate proportionate mortality ratios (PMRs), indirectly standardized for age, sex, race, and 5-year calendar period with 95% CIs, for NMRD and a group of International Classification of Diseases, Ninth and Tenth Revision codes approximating idiopathic pulmonary fibrosis.Among 21,928 dentist decedents with complete race information, 1,583 deaths (7.2%) resulted from NMRD. Proportionate mortality for dentist decedents was significantly lower than the general population for NMRD overall (PMR, 0.66; 95% CI, 0.62 to 0.69), chronic obstructive pulmonary disease (PMR, 0.44; 95% CI, 0.41 to 0.48), and pneumonia (PMR, 0.73; 95% CI, 0.67 to 0.81) but significantly higher than the general population for the pulmonary fibrosis group (PMR, 1.57; 95% CI, 1.37 to 1.80).Dentists had decreased proportionate mortality for most NMRD and increased proportionate mortality for underlying causes of death associated with pulmonary fibrosis.Existing engineering controls that reduce inhalational exposures during dental procedures might be inadequate. Improved characterization of these exposures could help inform more effective engineering controls.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "United States",
+ "Dentists",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Occupational Diseases",
+ "Aged",
+ "Cause of Death",
+ "Occupational Exposure",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39726246",
+ "Title": "Drug metabolism reviews",
+ "ArticleTitle": "Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review.",
+ "Abstract": "Several studies indicate various pharmacological and therapeutic effects of peroxisome proliferator-activated receptors (PPARs) in different disorders. The current review describes the influences of PPARs on respiratory, allergic, and immunologic diseases. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effect of PPARs on respiratory and allergic disorders from 1990 to 2024. The effects of PPARs stimulation on experimental animal models of respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), pulmonary fibrosis (PF), and lung infections were shown. Therapeutic potential mediated through PPARs has also been demonstrated in lung cancer, lung infections, and allergic and immunologic disorders. However, few clinical studies showed PPARs mediated therapeutic effects on asthma and COPD. The PPARs-mediated effects on various respiratory disorders were shown through antioxidant, immunomodulatory, anti-inflammatory, and other mechanisms. Therefore, this review indicated possible remedy effects mediated by these receptors in treating respiratory, allergic, and immunologic diseases. Moreover, this mechanistic review paves the way for researchers to consider further experimental and clinical studies.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Animals",
+ "Peroxisome Proliferator-Activated Receptors",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39724617",
"Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
"ArticleTitle": "LEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).",
- "Abstract": "The overall mortality of Chornobyl clean-up workers from non-tumor diseases tends to increase. Theresults of the risk analysis of dose dependent mortality in the Chornobyl clean-up workers cohort showed a highersensitivity to ionizing radiation of persons of the younger age group (18-39 years old at the date of the accident).The most dangerous period of relative dose-dependent risk of death of Chornobyl clean-up workers due to non-tumordiseases was established - 6-10 years after radiation exposure for all dose subgroups (from 0.05 Gy to 0.7 Gy) relative to the subgroup with a radiation dose < 0.05 Gy.",
+ "Abstract": "The emergency destruction of the 4th reactor of the Chornobyl nuclear power plant necessitated large-scale emergency work, which involved large contingents of specialists. Analysis the mortality of Chornobyl clean-up workers isan important and relevant basis for planning medical protection measures in conditions of a potential threat ofemergency and other radiation situations.The objective of this work is to determine the levels and relative risks of mortality of Chornobyl clean-up workers in1986-1987 years from major non-tumor diseases depending on the received dose of radiation exposure, taking intoaccount age and time after the accident (period of epidemiological studies 1988-2021).The cohort of Chornobyl clean-up workers in 1986-1987 years with a known dose of external \u03b3-irradiation of the whole body, totaling 64,490 male, was divided by age at the date of the accident at theChornobyl nuclear power plant and dose of external \u03b3-irradiation of the whole body. Epidemiological analysis of mortality from non-tumor diseases was conducted for the entire post-accident period and in dynamics over five-yearmonitoring periods.The highest mortality rate, regardless of age, on the date of the Chornobyl disaster, were from diseases of thecirculatory system, of the digestive and respiratory systems. For Chornobyl clean-up workers 18-39 years on the dateof the accident, relative risks of mortality from non-tumor diseases over the entire observation period were significantly higher in all dose subgroups (from 0.05 Gy to 0.7 Gy) compared to the dose subgroup < 0.05 Gy. In the period1993-1997 (6-10 years after the Chornobyl accident), significantly higher relative risks of mortality from diseases ofthe circulatory system (pulmonary heart and pulmonary circulatory disorders, cardiomyopathy, myocardial infarction)were found; in 26-30 years - from cerebrovascular diseases, including cerebral infarction. The indicated reliabledose-dependent relative risks are characteristic of all dose subgroups relative to the subgroup with a dose < 0.05 Gy.The overall mortality of Chornobyl clean-up workers from non-tumor diseases tends to increase. Theresults of the risk analysis of dose dependent mortality in the Chornobyl clean-up workers cohort showed a highersensitivity to ionizing radiation of persons of the younger age group (18-39 years old at the date of the accident).The most dangerous period of relative dose-dependent risk of death of Chornobyl clean-up workers due to non-tumordiseases was established - 6-10 years after radiation exposure for all dose subgroups (from 0.05 Gy to 0.7 Gy) relative to the subgroup with a radiation dose < 0.05 Gy.",
"Predictions": [
"Chronic respiratory disease",
"Cardiovascular diseases"
@@ -94,13 +157,18 @@
"Emergency Responders",
"Adolescent",
"Cardiomyopathies"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
"PMID": "39710468",
"Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
"ArticleTitle": "[Analysis of the distribution characteristics of allergen sIgE detection in patients with respiratory and skin mucosal diseases in a hospital in Shanghai City from 2022 to 2023].",
- "Abstract": "Analyzing the distribution characteristics of allergen sIgE in the serum of patients with respiratory and skin mucosal diseases in Shanghai City, and to provide epidemiological characteristics and diagnostic basis for the prevention and treatment of allergic respiratory and dermo-mucous diseases in Shanghai City. Adopting cross-sectional research, a total of 3 822 patients who received treatment in Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2022 to July 2023 due to respiratory diseases or skin and dermo-mucous symptoms were included. Among them, there were 1 456 males and 2 366 females, with an age range of 1-97 years old. The median age (interquartile range) was 33 (27, 44) years old. The sIgE was detected by using immunoblotting. Statistical analysis was conducted using SPSS 22.0 software, and the comparison of count data (rates) between groups was conducted using ",
+ "Abstract": "Analyzing the distribution characteristics of allergen sIgE in the serum of patients with respiratory and skin mucosal diseases in Shanghai City, and to provide epidemiological characteristics and diagnostic basis for the prevention and treatment of allergic respiratory and dermo-mucous diseases in Shanghai City. Adopting cross-sectional research, a total of 3 822 patients who received treatment in Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2022 to July 2023 due to respiratory diseases or skin and dermo-mucous symptoms were included. Among them, there were 1 456 males and 2 366 females, with an age range of 1-97 years old. The median age (interquartile range) was 33 (27, 44) years old. The sIgE was detected by using immunoblotting. Statistical analysis was conducted using SPSS 22.0 software, and the comparison of count data (rates) between groups was conducted using test. The results showed that a total of 3 377 (88.4%) cases among 3 822 patients were at least one allergen sIgE positive, and 72.9% (2 788/3 822) of them were multiple allergies sIgE positive. The top five allergen sIgE positive rates were Dermatophagoides pteronyssinus (37.9%, 1 447/3 822), Dermatophagoides farinae (32.1%, 1 225/3 822), milk (31.7%, 1 211/3 822), fungi (28.3%, 1 080/3 822), and Blomia tropicdis (23.8%, 909/3 822), with only milk was a kind of food allergen. The highest positive rates within the respiratory system disease group or dermo-mucous disease group were also these five allergens, without any difference in disease categories. The positive rates of cat dandruff, Humulusscandens, and juniper/birch in the respiratory system disease group were significantly higher than those in the skin and mucous membrane disease group, while the positive rates of shrimp/crab were relatively low (11.3% 14.9%, =9.616,=0.002). Whether in the respiratory system disease group or the dermo-mucous disease group, the positive rates of Dermatophagoides pteronyssinus in male patients were significantly higher than those of females(42.6% 35.7%,41.0% 34.4%), with statistical significance (=12.515, <0.001; =5.143, =0.023), And the three allergens, Dermatophagoides farinae, cat dander, and egg white allergens are also characterized by this feature.In addition, the positive rates of milk(33.8% 30.1%, =3.911, =0.048), shrimp/crab(13.2% 10.0%, =6.423, =0.014) in the respiratory system disease group were higher in males than in females, while in the dermo-mucous disease group, dog dander(20.5% 14.6%, =6.726, =0.010) and peanuts/soybeans(10.5% 6.9%, =4.698, =0.030) showed this phenomenon. In both the respiratory system disease group and the dermo-mucous disease group, there were 6 types of inhaled allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicdis, cat dandruff, dog dander, fungi) and 4 types of food allergens (egg yolks, egg white allergens, milk, shrimp/crab). However, the positivity rate of Aspergillus fumigatus (7.2% 9.3% 10.5% 15.7%, =10.996, =0.012)in the respiratory disease group and cockroaches(4.2% 11.3% 9.6% 16.4%, =10.237, =0.017) in the skin and mucosal disease group was the lowest in the underage group. There are seasonal differences in the positivity rates of allergens, with most allergens having significantly higher positivity rates in summer and autumn. In conclusion, the most common allergens sIgE positive in patients with respiratory and dermo-mucous diseases in Shanghai City are Dermatophagoides pteronyssinus, Dermatophagoides farinae, milk, fungi, and Blomia tropicdis. The trend of allergen sIgE prevalence in the two major categories of diseases is basically consistent. Allergen sIgE distribution varies among patient populations of different gender, age or season, and clinical prevention and treatment can be based on the results of serum allergen testing.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -124,13 +192,18 @@
"Animals",
"Skin Diseases",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
"PMID": "39707265",
"Title": "BMC public health",
"ArticleTitle": "Mediating effect of respiratory symptoms on the association between residential distance and the quality of life among residents living near waste incineration plants in Dongguan, Southern China.",
- "Abstract": "Residential distance from a WIP was significantly associated with QOL, and the association between residential distance and QOL was mediated by respiratory symptoms. Future longitudinal studies on adverse respiratory health effects of exposure to WIP emissions are required using objective assessments.",
+ "Abstract": "Living near waste incineration plants (WIPs) may have adverse effects on health associated with quality of life (QOL) among local residents. This study was undertaken to measure the QOL of residents living near WIPs in China, identify the association between residential distance from the WIPs and QOL, and assess the mediating effect of respiratory symptoms on the association between residential distance and QOL.A cross-sectional study was conducted in communities surrounding three municipal WIPs in Dongguan, China. The QOL using the WHOQOL-BREF and respiratory symptoms using the Medical Research Council Questionnaire (MRCQ) on Respiratory Symptoms were measured in 881 residents (454 living 3\u00a0km of their local WIP vs. 427 living 3-8\u00a0km from the WIP). Differences in respiratory symptoms and QOL in two separate items and four domains were analyzed. The associations of distance with respiratory symptoms and QOL were evaluated by multiple linear regression and logistic regression, respectively. Mediating effect of respiratory symptoms on the association between distance and QOL were tested using mediation analysis.Compared with the 3-8\u00a0km group, residents in the 0-3\u00a0km group had significantly lower scores in the physical health domain (\u03b2= -\u20092.02, p\u2009=\u20090.027), social relationships domain (\u03b2= -\u20092.47, p\u2009=\u20090.016) and environment domain (\u03b2= -\u20093.55, p\u2009<\u20090.001). There were no significant associations between distance and psychological domain, overall QOL, and satisfaction with health after adjusting for other variables. Residents in the 0-3\u00a0km group were more likely to report respiratory symptoms than residents in the 3-8\u00a0km group (OR\u2009=\u20091.46, 95%CI 1.09-1.96, p\u2009=\u20090.011). Respiratory symptoms had a significant effect on physical health (\u03b2= -\u20097.48, p\u2009<\u20090.001), social relationships (\u03b2= -\u20095.02, p\u2009<\u20090.001) and environment domains (\u03b2= -\u20097.28, p\u2009<\u20090.001). Respiratory symptoms fully mediated the association of residential distance on physical health (31.7%), and partially mediated the associations of residential distance on social relationships (18.8%) and environment domains (17.3%).Residential distance from a WIP was significantly associated with QOL, and the association between residential distance and QOL was mediated by respiratory symptoms. Future longitudinal studies on adverse respiratory health effects of exposure to WIP emissions are required using objective assessments.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -148,13 +221,18 @@
"Residence Characteristics",
"Aged",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
"PMID": "39696118",
"Title": "BMC public health",
"ArticleTitle": "Short-term exposure to outdoor nitrogen dioxide and respiratory mortality, with high-risk populations: a nationwide time-stratified case-crossover study.",
- "Abstract": "Numerous existing studies reported the negative impacts of outdoor nitrogen dioxide (NO",
+ "Abstract": "Numerous existing studies reported the negative impacts of outdoor nitrogen dioxide (NO) on respiratory mortality. However, the evidence of related high-risk populations was considerably limited, especially associated with ages, causes of death, and district-level characteristics. In addition, most earlier studies were based on monitored areas, thus previous risk estimates of NO could be biased to provide nationwide risk estimates and high-risk populations. Therefore, this study performed a nationwide time-stratified case-crossover study to evaluate the association between short-term ambient NO and respiratory mortality in South Korea (2015-2019). A machine learning-ensemble daily NO prediction model was used to cover unmonitored areas. To examine high-risk populations, we assessed NO risk estimates by age group, sex, cause of mortality, and district-level characteristics. In the total population, NO was weakly associated with increased mortality risk due to respiratory disease (OR [odds ratio]: 1.011, 95% CI [confidence interval]: 0.995-1.027), and the association became evident only in individuals aged 80 y or older (1.022, 1.000-1.044), especially related to pneumonia. Further, in people aged 60-69\u00a0years, NO was marginally associated with mortality for chronic lower respiratory diseases. Lower district-level socioeconomic status and medical services were marginally related to higher respiratory mortality risks related to NO. The excess respiratory mortality fractions and YLL (year of life lost) attributable to NO were 4.13% and 93,851.63\u00a0years, and around 70% of the excess deaths were due to noncompliance with the World Health Organization air quality guidelines (daily average NO\u2009>\u200925\u00a0\u00b5g/m). This study provides evidence for high-risk populations and the appropriateness of target-specific action plans against NO. In addition, based on the excess death estimates, we suggest stricter NO standards are required.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -179,13 +257,18 @@
"Air Pollution",
"Infant",
"Risk Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
"PMID": "39694698",
"Title": "BMJ open",
"ArticleTitle": "Long term exposure to ambient air pollution and hospital admission burden in Scotland: 16 year prospective population cohort study.",
- "Abstract": "The results of this study support an association between long term (16\u2009years) exposure to ambient air pollution and increased all cause and cause specific hospital admissions for both physical and mental/behavioural illnesses. The results suggest that interventions on air pollution through stricter environmental regulations could help ease the hospital care burden in Scotland in the long term.",
+ "Abstract": "Air pollution is considered a major threat for global health and is associated with various health outcomes. Previous research on long term exposure to ambient air pollution and health placed more emphasis on mortality rather than hospital admission outcomes and was characterised by heterogeneities in the size of effect estimates between studies, with less focus on mental/behavioural or infectious diseases outcomes. In this study, we investigated the association between long term exposure to ambient air pollution and all cause and cause specific hospital admissions.This was a prospective cohort study.Individual level data from the Scottish Longitudinal Study (SLS) were linked to yearly concentrations of four pollutants (nitrogen dioxide (NO), sulphur dioxide (SO), particulate matter diameter \u226410\u2009\u00b5m (PM) and particulate matter diameter \u22642.5\u2009\u00b5m (PM)) at 1 km spatial resolution using the individual's residential postcode for each year between 2002 and 2017.The study included 202\u2009237 adult individuals aged \u226517 years.The associations between air pollution and all cause, cardiovascular, respiratory, infectious, mental/behavioural disorders and other cause hospital admissions were examined using multi-level, mixed effects, negative binomial regression.Higher exposure to NO, PM and PM was associated with a higher incidence of all cause, cardiovascular, respiratory and infectious hospital admissions before adjusting for the area of residence, and in fully adjusted models when considering cumulative exposure across time. In fully adjusted models, the incidence rate for respiratory hospital admissions increased by 4.2% (95% CI 2.1% to 6.3%) and 1.2% (95% CI 0.8% to 1.7%) per 1 \u00b5g/m increase in PM and NO pollutants, respectively. SO was mainly associated with respiratory hospital admissions (incidence rate ratio (IRR)=1.016; 95% CI 1.004 to 1.027) and NO was related to a higher incidence of hospital admissions for mental/behavioural disorders (IRR=1.021; 95% CI 1.011 to 1.031). Average cumulative exposure to air pollution showed stronger positive associations with higher rates of hospital admissions.The results of this study support an association between long term (16\u2009years) exposure to ambient air pollution and increased all cause and cause specific hospital admissions for both physical and mental/behavioural illnesses. The results suggest that interventions on air pollution through stricter environmental regulations could help ease the hospital care burden in Scotland in the long term.",
"Predictions": [
"Chronic respiratory disease",
"Cardiovascular diseases"
@@ -212,7 +295,12 @@
"Adolescent",
"Respiratory Tract Diseases",
"Mental Disorders"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
"PMID": "39694558",
@@ -232,7 +320,12 @@
"Home Care Services",
"Practice Guidelines as Topic",
"Respiratory Therapy"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
"PMID": "39684326",
@@ -247,7 +340,12 @@
"Humans",
"Mast Cells",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "17"
+ }
},
{
"PMID": "39684250",
@@ -265,13 +363,18 @@
"Oxidative Stress",
"Respiratory Tract Diseases",
"Environmental Exposure"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "17"
+ }
},
{
"PMID": "39661886",
"Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
"ArticleTitle": "Violation of vitamin and mineral homeostasis in children with recurrent respiratory diseases.",
- "Abstract": "Conclusions: Positive correlations were observed with vitamins - Cyanocobalamin (r=0.40, p<0.01), vitamin C (r=0.43, p<0.01), Ferritin (r=0.35, p<0.01), Magnesium (r=0.27, p<0.003). Negative correlations of vitamins, in particular, Folic acid (r=-0.50, p<0.01), vitamin A (r=-0.40, p<0.01) and Phosphorus minerals (r=-0.75 , p<0.01), Sodium (r=-0.51, p<0.01), Potassium (r=-0.24, p=0.008), Chlorine (r=-0.38, p<0 ,01).",
+ "Abstract": "Aim: To examine and analyze the state of vitamin and mineral homeostasis in children with recurrent respiratory diseases.Materials and Methods: To achieve the goal, 62 children of primary school age with a diagnosis of Recurrent Respiratory diseases were examined in comparison with data of healthy children of the control group (n=26). The study included a clinical examination of children, determination of serum vitamin and mineral levels.Results: A dinamic decreasing in the level of vitamins beyond the reference range was found: vitamin D (in 1.4 times ) vitamin C ( in 1.4 times lower than the data of the control group, and Cyanocobalamin (in 1.9 times) in relation to the data of the control group. Calcium levels were below the limit of reference values, both total (2.14 \u00b1 0.04 mmol/l vs. 2.53 \u00b1 0.07 mmol/l, p<0.01) and ionized (1.15 \u00b1 0.01 mmol/l compared 1.26 \u00b1 0.05 mmol/l, p<0.01). At the lower limit of the reference, there were significant differences in the levels of Zinc (p<0.01, 1.6 times), Copper ( p<0.01, 1.4 times) and unreliable - Magnesium (p<0.12), sodium (p<0.62 ).Conclusions: Positive correlations were observed with vitamins - Cyanocobalamin (r=0.40, p<0.01), vitamin C (r=0.43, p<0.01), Ferritin (r=0.35, p<0.01), Magnesium (r=0.27, p<0.003). Negative correlations of vitamins, in particular, Folic acid (r=-0.50, p<0.01), vitamin A (r=-0.40, p<0.01) and Phosphorus minerals (r=-0.75 , p<0.01), Sodium (r=-0.51, p<0.01), Potassium (r=-0.24, p=0.008), Chlorine (r=-0.38, p<0 ,01).",
"Predictions": [
"Chronic respiratory disease"
],
@@ -287,13 +390,18 @@
"Respiratory Tract Diseases",
"Vitamin D",
"Recurrence"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "11"
+ }
},
{
"PMID": "39661885",
"Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
"ArticleTitle": "Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy scheme.",
- "Abstract": "Conclusions: The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (\u04403<0,01; \u04404<0,01; \u04405<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.",
+ "Abstract": "Aim: To improve the early diagnosis, course, prediction of the development of Acute Respiratory pathology in children, taking into account the state of antioxidant system (AOS).Materials and Methods: The research group included school-age children (10-14 years old) with Acute Respiratory pathologe (n=111) and a control group (n=25).diseases in comparation.Results: The highest positive correlation between ferritin and TNF- \u03b1 (r=0,41, p=0,001); Cortisol with Glutathione peroxidase (r=0,35, p=0,006) were observed. Ascorbic acid presented positive interactions on the values of Il-6 and Il-2 (r=0,27, 0,26, respectively). The value of vitamin D is represented in positive interactions with \u03b3-IFN (r=0,30), leptin (r=0,38) and Cu (r=0,32). The negative relationship of Zn with Il-6 was transformed for supporting immune barriers and protein metabolism.Conclusions: The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (\u04403<0,01; \u04404<0,01; \u04405<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -312,13 +420,18 @@
"Tumor Necrosis Factor-alpha",
"Respiratory Tract Diseases",
"Acute Disease"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "11"
+ }
},
{
"PMID": "39659714",
"Title": "Frontiers in public health",
"ArticleTitle": "Occupation-related respiratory diseases among sanitary workers in the workplace: a systematic review and meta-analysis.",
- "Abstract": "The current systematic review and meta-analysis found that ORRD were common among the SWs. Due to numerous risk factors, these illnesses are more prevalent in low-income countries than in industrialized ones. Therefore, to reduce these risks for these groups-especially for street sweepers in low-income countries-government policy changes and other preventive measures are required.",
+ "Abstract": "Emerging evidence from both developed and developing countries indicates that occupation-related respiratory diseases (ORRD) among sanitary workers constitute a significant public health challenge. These are because of the working environment, where employees are more likely to be at risk in an unsafe workplace, especially sanitary workers. Therefore, the purpose of this systematic review and meta-analysis was to estimate the prevalence of ORRD among sanitary workers.The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram was used, and the Population, Intervention, Comparison, Outcomes, and Study (PICOS) framework was applied to structure the review questions. Studies published in English from 2000 to 2022 were searched in databases and through other methods. Boolean logic (AND, OR, NOT), Medical Subject Headings (MeSH), and keywords were used as follows: (Occupational \"OR\" Job \"OR\" Work) AND (Respiratory tract diseases \"OR\" Respiratory tract infections \"OR\" Respiratory tract symptoms \"OR\" Respiratory tract problems) AND (Solid waste collectors \"OR\" Sewage workers \"OR\" Street sweepers \"OR\" Waste treatment worker) AND Countries. Stata MP/17 software was used for data analysis. A random effects model and restricted maximum likelihood were applied. A generic precomputed effect size for the prevalence of ORRD was employed at a 95% confidence interval (CI:95%).A total of 23 studies were included, four from industrialized countries (\u202f=\u202f4) and seven from developing countries (\u202f=\u202f7), out of an initial 123 studies. Among the 4,521 sanitary workers, 1990 (44%), 1,651 (37%), and 880 (19%) were SS, SWCs, and STWs, respectively. Globally, the pooled prevalence of ORRD among all SWs was 32.56% (95%CI: 25.78, 39.34%). Among these, high-income and low-income countries had a prevalence of 20% (95%CI: 18.08%, 0.21.96%) and 35.17% (95%CI: 27.48, 42.76%), respectively. In the SS and SWC groups, the prevalence was 36.41% (95%CI: 26.69%) and 31.28% (95%CI, 18.64, 43.92%), respectively.The current systematic review and meta-analysis found that ORRD were common among the SWs. Due to numerous risk factors, these illnesses are more prevalent in low-income countries than in industrialized ones. Therefore, to reduce these risks for these groups-especially for street sweepers in low-income countries-government policy changes and other preventive measures are required.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -328,13 +441,18 @@
"Occupational Diseases",
"Respiratory Tract Diseases",
"Prevalence"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "11"
+ }
},
{
"PMID": "39643329",
"Title": "The Lancet. Public health",
"ArticleTitle": "Associations of long-term nitrogen dioxide exposure with a wide spectrum of diseases: a prospective cohort study of 0\u00b75 million Chinese adults.",
- "Abstract": "Wellcome Trust, UK Medical Research Council, Cancer Research UK, British Heart Foundation, National Natural Science Foundation of China, National Key Research and Development Program of China, Sino-British Fellowship Trust, and Kadoorie Charitable Foundation.",
+ "Abstract": "Little evidence is available on the long-term health effects of nitrogen dioxide (NO) in low-income and middle-income populations. We investigated the associations of long-term NO exposure with the incidence of a wide spectrum of disease outcomes, based on data from the China Kadoorie Biobank.This prospective cohort study involved 512\u2008724 Chinese adults aged 30-79 years recruited from ten areas of China during 2004-08. Time-varying Cox regression models yielded adjusted hazard ratios (HRs) for the associations of long-term NO exposure with aggregated disease incidence endpoints classified by 14 ICD-10 chapters, and incidences of 12 specific diseases selected from three key ICD-10 chapters (cardiovascular, respiratory, and musculoskeletal diseases) found to be robustly associated with NO in the analyses of aggregated endpoints. All models were stratified by age-at-risk (in 1-year scale), study area, and sex, and were adjusted for education, household income, smoking status, alcohol intake, cooking fuel type, heating fuel type, self-reported health status, BMI, physical activity level, temperature, and relative humidity.The analysis of 512\u2008709 participants (mean baseline age 52\u00b70 years [SD 10\u00b77]; 59\u00b70% female and 41\u00b70% male) included approximately 6\u00b75 million person-years of follow-up. Between 5285 and 144\u2008852 incident events were recorded for each of the 14 aggregated endpoints. Each 10 \u03bcg/m higher annual average NO exposure was associated with higher risks of chapter-specific endpoints, especially cardiovascular (n=144\u2008852; HR 1\u00b704 [95% CI 1\u00b702-1\u00b705]), respiratory (n=73\u2008232; 1\u00b703 [1\u00b701-1\u00b705]), musculoskeletal (n=54\u2008409; 1\u00b711 [1\u00b709-1\u00b714]), and mental and behavioural (n=5361; 1\u00b712 [1\u00b705-1\u00b721]) disorders. Further in-depth analyses on specific diseases found significant positive supra-linear associations with hypertensive disease (1\u00b708 [1\u00b705-1\u00b711]), lower respiratory tract infection (1\u00b703 [1\u00b701-1\u00b706]), arthrosis (1\u00b715 [1\u00b709-1\u00b721]), intervertebral disc disorders (1\u00b713 [1\u00b709-1\u00b717]), and spondylopathies (1\u00b705 [1\u00b701-1\u00b710]), and linear associations with ischaemic heart disease (1\u00b703 [1\u00b700-1\u00b705]), ischaemic stroke (1\u00b708 [1\u00b706-1\u00b711]), and asthma (1\u00b715 [1\u00b704-1\u00b727]), whereas intracerebral haemorrhage (1\u00b700 [0\u00b795-1\u00b706]), other cerebrovascular disease (0\u00b798 [0\u00b796-1\u00b701]), acute upper respiratory infection (1\u00b703 [0\u00b796-1\u00b709]), and chronic lower respiratory disease (0\u00b798 [0\u00b795-1\u00b702]) showed no significant association. NO exposure showed robust null association with external causes (n=32\u2008907; 0\u00b798 [0\u00b795-1\u00b702]) as a negative control.In China, long-term NO exposure was associated with a range of diseases, particularly cardiovascular, respiratory, and musculoskeletal diseases. These associations underscore the pressing need to implement the recently tightened WHO air quality guidelines.Wellcome Trust, UK Medical Research Council, Cancer Research UK, British Heart Foundation, National Natural Science Foundation of China, National Key Research and Development Program of China, Sino-British Fellowship Trust, and Kadoorie Charitable Foundation.",
"Predictions": [
"Chronic respiratory disease",
"Cardiovascular diseases"
@@ -356,13 +474,18 @@
"Respiratory Tract Diseases",
"Air Pollutants",
"East Asian People"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "7"
+ }
},
{
"PMID": "39642570",
"Title": "International immunopharmacology",
"ArticleTitle": "Health assessment of sulfur mustard-chemical veterans with various respiratory diseases: The result of a comparative analysis of biological health scores (BHS) through 50 biomarkers.",
- "Abstract": "The modified multisystem BHS could be useful in the more accurate evaluation of biological health in chronic SM toxicity. The dysregulation observed in the endocrine and metabolic systems underscores the complication of SM toxicity and its extensive consequences on physiological homeostasis.",
+ "Abstract": "Mustard gas as a chemical weapon has been used in wars and its long-term side effects are substantial in the human body. This study aimed to apply an extension of allostatic load, known as biological health score (BHS), including the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular, and metabolic systems) to estimate biological health caused by sulfur mustard (SM) toxicity.In this cross-sectional study, serum samples were collected from two distinct groups of male individuals including 1) 236 individuals who had been exposed to SM gas during the Iraq-Iran war in 1987. This group was divided into three subgroups based on their respiratory disorders (19 individuals with asthma, 92 individuals with bronchiolitis obliterans, and 125 individuals with chronic bronchitis); 2) 64 healthy members, at the same range of age and residence, as the non-exposed group. To estimate a modified BHS, 50 blood-derived biomarkers (or their ratios) of the mentioned systems were measured.The SM-exposed group and respiratory disease subgroups exhibited higher BHS than controls (P < 0.05). The endocrine and metabolic systems exhibited higher BHS in the SM-exposed group and its subgroups compared to the control group (P < 0.05). In contrast, the cardiovascular and immune/inflammatory systems did not show significant differences between the groups. Principal component analysis (PCA) identified several key biomarkers, including lymphocyte count, the LDH/lymphocyte ratio, cholesterol levels, and neutrophil count, as major contributors to interpatient variation among individuals exposed to SM and those with related respiratory diseases.The modified multisystem BHS could be useful in the more accurate evaluation of biological health in chronic SM toxicity. The dysregulation observed in the endocrine and metabolic systems underscores the complication of SM toxicity and its extensive consequences on physiological homeostasis.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -378,13 +501,18 @@
"Middle Aged",
"Respiratory Tract Diseases",
"Iran"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "7"
+ }
},
{
"PMID": "39640901",
"Title": "BioMed research international",
"ArticleTitle": "Indigenous Knowledge and Quantitative Analysis of Medicinal Plants Used to Remedy Respiratory Tract Disorders in Mid-Western Tanzania.",
- "Abstract": "This study is aimed at documenting the indigenous knowledge and quantitative analysis of medicinal plants (MPs) used by traditional health practitioners (THPs) of Urambo District in mid-western Tanzania to manage respiratory tract disorders (RTDs). The ethnomedicinal data were collected using semistructured interviews with 55 THPs using a snowballing technique in the district. The data were analysed for indigenous knowledge among gender, age groups, education status, and experience. Family importance value (FIV), use value (UV), relative frequency of citation (RFC), informant consensus factor (ICF), and Jaccard index (JI) were computed. A total of 42 MPs representing 28 families were recorded being used against RTDs in the district. Fabaceae was the dominant family in terms of species (16.7%) and FIV (84%). Decoction (51.0%) was the preferred technique for preparing remedies, while trees (61.9%) and leaves (38.1%) were the most utilised life form and plant parts, respectively. The RFC in the current study varied from 0.055 (",
+ "Abstract": "This study is aimed at documenting the indigenous knowledge and quantitative analysis of medicinal plants (MPs) used by traditional health practitioners (THPs) of Urambo District in mid-western Tanzania to manage respiratory tract disorders (RTDs). The ethnomedicinal data were collected using semistructured interviews with 55 THPs using a snowballing technique in the district. The data were analysed for indigenous knowledge among gender, age groups, education status, and experience. Family importance value (FIV), use value (UV), relative frequency of citation (RFC), informant consensus factor (ICF), and Jaccard index (JI) were computed. A total of 42 MPs representing 28 families were recorded being used against RTDs in the district. Fabaceae was the dominant family in terms of species (16.7%) and FIV (84%). Decoction (51.0%) was the preferred technique for preparing remedies, while trees (61.9%) and leaves (38.1%) were the most utilised life form and plant parts, respectively. The RFC in the current study varied from 0.055 ( L.) to 0.655 ( Roscoe) and 0.073 ( (L.) Wight & Arn.) to 0.673 ( Steud. ex A.Rich.), respectively. The highest ICF was recorded for cough (0.922). The JI ranged from 2.7 to 7.9. Among the documented MPs, 55% had least concern, 2% were endangered, 7% had data deficiency conservation status, and 36% had no record in the IUCN Red List. The study revealed that the district's population depends on MPs for healthcare. Thus, conservation strategies are needed for the sustainable utilisation of the MPs. Importantly, the documented MPs hold immense potential in future pharmacological and phytochemical studies, offering hope for the development of new drugs for RTDs. Also, the study suggests the need for scientific validation of the MP's efficacy and safety.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -401,7 +529,12 @@
"Medicine, African Traditional",
"Aged",
"Phytotherapy"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "6"
+ }
},
{
"PMID": "39633457",
@@ -420,13 +553,18 @@
"Air Pollutants",
"Animals",
"Respiratory System"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
"PMID": "39633418",
"Title": "Journal of health, population, and nutrition",
"ArticleTitle": "Short-term effects of air pollutants on hospitalization for childhood respiratory diseases in Suzhou City: a time-stratified case-crossover study.",
- "Abstract": "The short-term exposure to PM",
+ "Abstract": "Short-term exposure to air pollution has been demonstrated in previous studies to correlate with respiratory disease (RD) in children. Due to regional heterogeneity, our objective was to explore the correlation between short-term exposure to ambient air pollution and hospital admissions for respiratory ailments in children in Suzhou City from January 1, 2017, to December 31, 2022, alongside assessing the influence of the COVID-19 pandemic on this relationship.We collected data on air pollutant levels and hospital admissions for childhood respiratory disease (RD) in Suzhou, China, from 2017 to 2022. We utilized a time-stratified case-crossover design along with a conditional logistic regression model to assess the short-term impacts of air pollutants on RD in children through stratified analysis and sensitivity analysis.A total of 13,408 children with respiratory diseases were included in the study. The findings revealed significant associations between hospitalization for respiratory diseases in children and exposure to PM, PM, SO, NO, and CO. The maximum effect values (95%CI, best lag days) for each 10\u00a0\u00b5g/m increase in the concentrations of PM, PM, SO, and NO were as follows: 1.017 (1.003-1.031, lag0-2), 1.015 (1.004-1.026, lag0-2), 1.117 (1.001-1.247, lag0-1), and 1.036 (1.009-1.064, lag0-7). Additionally, the maximum effect value (95%CI, best lag days) for each 1 mg/m increase in CO concentration was found to be 1.267 1.017-1.579, lag0-7). Stratified analysis indicated that sex, season of admission, and stage of admission did not modify these correlations significantly; however, differential effects on various age groups and sexes were primarily observed among school-age and older children as well as boys.The short-term exposure to PM, PM, SO, NO, and CO in Suzhou, China, exhibited a positive correlation with RD hospitalization. Prior to the COVID-19 pandemic, the adverse impacts of air pollutants on hospitalizations for childhood respiratory disease were mitigated compared to the period following the pandemic. Local governments should continue promoting decisions and measures for air pollution prevention and control to reduce further pollutant concentration, which is crucial for public health in reducing the burden of childhood respiratory diseases.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -451,13 +589,18 @@
"Adolescent",
"Nitrogen Dioxide",
"Time Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
"PMID": "39632975",
"Title": "Scientific reports",
"ArticleTitle": "Mendelian randomization study on the association of circulating ketone bodies with lung cancer and respiratory diseases.",
- "Abstract": "The liver produces various ketone bodies (KBs) including 3-Hydroxybutyrate (3-OHB), acetoacetate (AcAc), and acetone, with 3-OHB being the major component. Previous studies have shown that KBs protect against respiratory diseases; however, there is no evidence of a genetic link. To avoid biases existing in traditional observational studies, a two-sample Mendelian randomization (MR) analysis was carried out to investigate genetic causation and novel therapeutic uses for KBs. This study used databases from genome-wide association studies (GWAS) and single nucleotide polymorphisms as instrumental variables for KBs from a recently published metabonomics study (n\u2009=\u2009121,584) and respiratory diseases [lung cancer, n\u2009=\u200985,716; asthma, n\u2009=\u2009127,669; chronic bronchitis, n\u2009=\u2009450,422; chronic obstructive pulmonary disease (COPD), n\u2009=\u2009468,475; FEV",
+ "Abstract": "The liver produces various ketone bodies (KBs) including 3-Hydroxybutyrate (3-OHB), acetoacetate (AcAc), and acetone, with 3-OHB being the major component. Previous studies have shown that KBs protect against respiratory diseases; however, there is no evidence of a genetic link. To avoid biases existing in traditional observational studies, a two-sample Mendelian randomization (MR) analysis was carried out to investigate genetic causation and novel therapeutic uses for KBs. This study used databases from genome-wide association studies (GWAS) and single nucleotide polymorphisms as instrumental variables for KBs from a recently published metabonomics study (n\u2009=\u2009121,584) and respiratory diseases [lung cancer, n\u2009=\u200985,716; asthma, n\u2009=\u2009127,669; chronic bronchitis, n\u2009=\u2009450,422; chronic obstructive pulmonary disease (COPD), n\u2009=\u2009468,475; FEV/FVC\u2009<\u20090.7, n\u2009=\u2009353,315] from their publicly available GWAS, respectively. Strong sets of instrumental variables (P\u2009<\u20095\u2009\u00d7\u200910) were selected, with inverse-variance weighted as the primary MR method. Sensitivity analyses included Cochran's Q test, MR Egger, MR-PRESSO, leave-one-out test, and funnel plots. The Steiger test and reversed MR were used to exclude reverse causality. Additionally, independent replication MR studies were conducted using databases from another large public GWAS and similar methods as described above. After MR analyses and sensitivity filtering, we discovered a protective effect of 3-OHB on lung cancer (odds ratio [OR]\u2009=\u20090.771; 95% confidence interval [CI]\u2009=\u20090.648-0.916; P=0.006), small cell carcinoma (OR\u2009=\u20090.485, 95% CI\u2009=\u20090.301-0.781, P=0.006), asthma (OR\u2009=\u20090.585, 95% CI\u2009=\u20090.395-0.867, P=0.010), chronic bronchitis (OR\u2009=\u20090.753, 95% CI\u2009=\u20090.570-0.994, P=0.045), COPD (OR\u2009=\u20090.690, 95% CI\u2009=\u20090.535-0.890, P=0.008) and lung function (OR\u2009=\u20090.970, 95%CI\u2009=\u20090.950-0.990, P =0.008). In summary, our findings suggest that 3-OHB acts as a protective factor against lung cancer and respiratory diseases. However, heterogeneity implies that other mechanisms may also be involved in COPD improvement by 3-OHB.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -469,13 +612,18 @@
"Ketone Bodies",
"Polymorphism, Single Nucleotide",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
"PMID": "39620702",
"Title": "Current opinion in pulmonary medicine",
"ArticleTitle": "The impact of climate change on respiratory health: current understanding and knowledge gaps.",
- "Abstract": "A better understanding of which components of climate change most impact human health is needed in order to re-define environmental standards. PM 2.5 needs to be broken down by chemical composition to study the differential impacts of different sources of PM 2.5 . The detection and study of climate-related changes in respiratory infectious diseases is in a state of relative infancy.",
+ "Abstract": "To present an overview of the impact of climate change upon human respiratory health.Climate change is directly impacting air quality. Particulate matter clearly increases mortality rates. Ozone, a longstanding suspect in climate-related injury, turns out not to have the major impact that had been projected at current levels of exposure. The key factors in global warming have been clearly identified, but while these factors collectively cause deleterious changes, a close look at the literature shows that it is unclear to what extent each factor individually is a driver of a specific process. This article summarizes some of those studies.A better understanding of which components of climate change most impact human health is needed in order to re-define environmental standards. PM 2.5 needs to be broken down by chemical composition to study the differential impacts of different sources of PM 2.5 . The detection and study of climate-related changes in respiratory infectious diseases is in a state of relative infancy.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -488,7 +636,12 @@
"Ozone",
"Respiratory Tract Diseases",
"Air Pollutants"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
"PMID": "39617287",
@@ -512,13 +665,18 @@
"Pesticides",
"Respiratory Tract Diseases",
"Environmental Pollutants"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
"PMID": "39615506",
"Title": "Lancet (London, England)",
"ArticleTitle": "Global, regional, and national mortality burden attributable to air pollution from landscape fires: a health impact assessment study.",
- "Abstract": "Australian Research Council, Australian National Health and Medical Research Council.",
+ "Abstract": "Landscape fire-sourced (LFS) air pollution is an increasing public health concern in the context of climate change. However, little is known about the attributable global, regional, and national mortality burden related to LFS air pollution.We calculated country-specific population-weighted average daily and annual LFS fine particulate matter (PM) and surface ozone (O) during 2000-19 from a validated dataset. We obtained the relative risks (RRs) for both short-term and long-term impact of LFS PM and O on all-cause, cardiovascular, and respiratory mortality. The short-term RRs were pooled from community-specific standard time-series regressions in 2267 communities across 59 countries or territories. The long-term RRs were obtained from published meta-analyses of cohort studies on all-source PM and O. Annual mortality, population, and socio-demographic data for each country or territory were extracted from the Global Burden of Diseases Study 2019. These data were used to estimate country-specific annual deaths attributable to LFS air pollution using standard algorithms.Globally, 1\u00b753 million all-cause deaths per year (95% empirical confidence interval [eCI] 1\u00b724-1\u00b782) were attributable to LFS air pollution during 2000-19, including 0\u00b745 million (0\u00b732-0\u00b757) cardiovascular deaths and 0\u00b722 million respiratory deaths (0\u00b708-0\u00b735). LFS PM and O contributed to 77\u00b76% and 22\u00b74% of the total attributable deaths, respectively. Over 90% of all attributable deaths were in low-income and middle-income countries, particularly in sub-Saharan Africa (606\u2009769 deaths per year), southeast Asia (206\u2009817 deaths), south Asia (170\u2009762 deaths), and east Asia (147\u2009291 deaths). The global cardiovascular attributable deaths saw an average 1\u00b767% increase per year (p <0\u00b7001), although the trends for all-cause and respiratory attributable deaths were not statistically significant. The five countries with the largest all-cause attributable deaths were China, the Democratic Republic of the Congo, India, Indonesia, and Nigeria, although the order changed in the second decade. The leading countries with the greatest attributable mortality rates (AMRs) were all in sub-Saharan Africa, despite decreasing trends from 2000 to 2019. North and central America, and countries surrounding the Mediterranean, showed increasing trends of all-cause, cardiovascular, and respiratory AMRs. Increasing cardiovascular AMR was also observed in southeast Asia, south Asia, and east Asia. In 2019, the AMRs in low-income countries remained four times those in high-income countries, though this had reduced from nine times in 2000. AMRs negatively correlated with a country-specific socio-demographic index (Spearman correlation coefficients r around -0\u00b760).LFS air pollution induced a substantial global mortality burden, with notable geographical and socioeconomic disparities. Urgent actions are required to address such substantial health impact and the associated environmental injustice in a warming climate.Australian Research Council, Australian National Health and Medical Research Council.",
"Predictions": [
"Chronic respiratory disease",
"Cardiovascular diseases"
@@ -538,13 +696,18 @@
"Particulate Matter",
"Respiratory Tract Diseases",
"Wildfires"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "1"
+ }
},
{
"PMID": "39608993",
"Title": "BMJ open",
"ArticleTitle": "Hospitalisation patterns for respiratory diseases in Australia: an ecological study.",
- "Abstract": "Hospital admissions due to diseases of the respiratory system increased significantly in the last two decades in Australia. Male gender and younger age groups were more likely to be hospitalised for respiratory diseases. Strong public health measures are crucial to raising awareness about diseases of the respiratory system and their implications.",
+ "Abstract": "The objective of this study is to examine the hospitalisation profile for respiratory diseases in Australia between 1998 and 2019.An ecological study.A population study that involved all private and public hospitalisations for respiratory diseases in Australia from 1998 to 2019. Data were gathered from the National Hospital Morbidity Database.All patients who were hospitalised at all private and public hospitalisations for respiratory diseases in Australia.Hospitalisation rates related to respiratory diseases.A total of 8\u2009090\u2009021 hospital admission episodes for diseases of the respiratory system were recorded in Australia between 1998 and 2019. Hospital admission rates increased by 12.4%, from 1766.45 (95% CI 1760.50 to 1772.41) in 1998 to 1985.86 (95% CI 1980.43 to 1991.28) in 2019 per 100\u2009000 persons, p<0.05. Patients who were admitted for an overnight stay made up 82.2% of the total admissions. Females showed a greater increase in hospital admission rates (18.4%) compared with males (7.0%). The age group 15-59 years accounted for 31.0% of the total admissions. The most frequent respiratory system hospital admissions were for chronic lower respiratory diseases; these accounted for 27.8% of all admissions.Hospital admissions due to diseases of the respiratory system increased significantly in the last two decades in Australia. Male gender and younger age groups were more likely to be hospitalised for respiratory diseases. Strong public health measures are crucial to raising awareness about diseases of the respiratory system and their implications.",
"Predictions": [
"Chronic respiratory disease"
],
@@ -567,1780 +730,1765 @@
"Aged, 80 and over",
"Sex Distribution",
"Age Distribution"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "29"
+ }
},
{
- "PMID": "39607106",
- "Title": "Cadernos de saude publica",
- "ArticleTitle": "Identifying high occurrence areas of hospitalization and mortality from respiratory diseases in the Brazilian Legal Amazon: a space-time analysis.",
- "Abstract": "Respiratory diseases pose a significant threat to the health of the Brazilian population, ranking among the leading causes of hospitalizations and deaths in the country. The most impacted demographics are children, adolescents, and older adults, who respectively have the highest rates of hospitalizations and deaths. An exploratory ecological study was conducted to assess the spatio-temporal distribution of hospitalizations and deaths due to respiratory diseases among children, adolescents, and older adults residing in municipalities in the Brazilian Legal Amazon. Moreover, the study aimed to identify priority municipalities within the detected clusters by employing composite synthetic municipal indices. These indices were estimated based on various socio-environmental and health indicators. The scan analysis identified clusters across various time periods but they mostly aligned with the disease trends in the region. We were able to identify clusters both near metropolitan areas and in remote locations, capturing two distinct patterns of cluster distribution. Moreover, the application of composite synthetic indices enabled a comprehensive identification of priority municipalities, considering various factors relevant to the health conditions of the population in the studied areas.",
+ "PMID": "39566532",
+ "Title": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
+ "ArticleTitle": "[Research progress on the role of exosomes in respiratory diseases].",
+ "Abstract": "Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine. During the progression of respiratory tract diseases, exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins, disrupting the respiratory defense system and inducing or exacerbating the disease. Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases, which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections. The treatment of respiratory diseases is also closely related to exosomes. The low immunogenicity and high compatibility of exosomes make them effective tools for delivering molecules and drugs for treatment.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Exosomes",
"Humans",
- "Brazil",
- "Hospitalization",
- "Adolescent",
- "Spatio-Temporal Analysis",
- "Child",
"Respiratory Tract Diseases",
- "Young Adult",
- "Adult",
- "Socioeconomic Factors",
- "Child, Preschool",
- "Female",
- "Male",
- "Middle Aged",
- "Aged",
- "Cluster Analysis",
- "Infant",
- "Urban Population",
- "Space-Time Clustering",
- "Cities"
- ]
+ "Animals",
+ "Biomarkers"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39603392",
- "Title": "Respiratory medicine",
- "ArticleTitle": "Characteristics of rehabilitation programs for chronic respiratory diseases in Asia: A scoping review.",
- "Abstract": "The rates of chronic respiratory disease (CRD) is rising in Asia. Pulmonary rehabilitation (PR) has been shown to be a highly efficacious intervention for people with CRD. While PR models are well established in Western countries, environmental, cultural and societal factors may influence how rehabilitation programs for people with CRD are conducted in Asia. This review aims to identify the characteristics of rehabilitation programs for people with CRD within Asia and identify differences between these rehabilitation programs to the recently updated American Thoracic Society (ATS) PR guidelines. Utilising the PRISMA scoping review guidelines, five databases- CINAHL, Medline, Embase, Web of Science and Health and Medical Collection were searched from inception until 13th December 2023. A total of 137 studies (n\u00a0=\u00a019,128) were included in the review. As many as 113 studies (83\u00a0%) included aerobic exercises as part of rehabilitation, only 90 studies (66\u00a0%) included resistance training. Thirty-nine studies included interventions such as Tai Chi, Qigong and Yoga. Comparing to the 2023 ATS PR guidelines, only 22\u00a0% of the included studies evaluated a rehabilitation program that was consistent with the guidelines. Improvement in exercise capacity (76\u00a0%) and quality of life (QOL) (73\u00a0%) were the most frequent outcomes used to evaluate program efficacy. The results suggest that models of rehabilitation varied greatly within the Asia region, with some more heavily adapted to suit the local context as compared to others. Further consideration on how to balance adaptation of PR with fidelity of the intervention needs to be taken.",
+ "PMID": "39544058",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Volatile organic compounds and respiratory diseases].",
+ "Abstract": "Our home is a place of refuge and protection, where we spend an average of 80 % of our time. Indoor air quality is an essential element that directly influences the health and well-being of individuals. The main sources of indoor pollution are human activity, which releases not only fine particles and carbon monoxide, but also volatile organic compounds (VOCs). A growing number of studies show a relationship between respiratory pathologies such as chronic obstructive pulmonary disease, asthma or Sick Building Syndrome, and exposure to VOCs. The aim of this article is to explore the relationship between VOCs and respiratory diseases, as well as the strategies to prevent their effect on health.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Asia",
- "Chronic Disease",
- "Quality of Life",
- "Qigong",
- "Yoga",
- "Tai Ji",
- "Resistance Training",
+ "Volatile Organic Compounds",
+ "Air Pollution, Indoor",
+ "Pulmonary Disease, Chronic Obstructive",
"Respiratory Tract Diseases",
- "Exercise Therapy",
- "Exercise Tolerance",
- "Practice Guidelines as Topic"
- ]
+ "Asthma",
+ "Sick Building Syndrome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39578996",
- "Title": "Journal of cachexia, sarcopenia and muscle",
- "ArticleTitle": "Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.",
- "Abstract": "Low grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle-related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials.",
+ "PMID": "39515807",
+ "Title": "Allergologia et immunopathologia",
+ "ArticleTitle": "Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases.",
+ "Abstract": "Respiratory diseases in children are common health problems that significantly impact their quality of life and health status, and this has its own unique challenges compared to adults. A growing body of research has focused on epigenetic mechanisms that relate with the development of various diseases, such as pediatric respiratory diseases. Noncoding RNAs (ncRNAs), especially long noncoding RNAs, microRNA, and circular RNA, are reported to play a regulatory role in pediatric respiratory diseases whose mutations or aberrant expressions are strongly associated with the development of these diseases. In this review, we mainly discussed the functions of these three ncRNAs in pediatric respiratory diseases.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Middle Aged",
- "Prospective Studies",
- "Adult",
- "Aged",
- "China",
- "Aged, 80 and over",
- "Hand Strength",
+ "Child",
+ "RNA, Untranslated",
+ "RNA, Long Noncoding",
+ "Epigenesis, Genetic",
+ "MicroRNAs",
"Respiratory Tract Diseases",
- "Muscle, Skeletal",
- "Muscle Strength",
- "East Asian People"
- ]
- },
- {
- "PMID": "39578779",
- "Title": "Molecular medicine (Cambridge, Mass.)",
- "ArticleTitle": "Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases.",
- "Abstract": "Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member of the Smad family proteins, mainly participating in the bone morphogenetic protein (BMP) signaling pathway in its phosphorylated form. This article will provide a detailed review of Smad5, focusing on its gene characteristics, protein structure, and subcellular localization properties. We will also explore the related signaling pathways and the mechanisms of Smad5 in respiratory diseases, including chronic obstructive pulmonary disease (COPD), bronchial asthma, pulmonary arterial hypertension(PAH), lung cancer, and idiopathic pulmonary fibrosis (IPF). Additionally, the review will cover aspects such as proliferation, differentiation, apoptosis, anti-fibrosis, and mitochondrial function metabolism. In addition, the review will cover aspects of proliferation, differentiation, apoptosis, anti-fibrosis and functional mitochondrial metabolism related to the above topics. Numerous studies suggest that Smad5 may play a unique and important role in the pathogenesis of respiratory system diseases. However, in previous research, Smad5 was mainly used to broadly determine the activation of the BMP signaling pathway, and its own function has not been given much attention. It is worth noting that Smad5 has distinct nuclear-cytoplasmic distribution characteristics different from Smad1 and Smad8. It can undergo significant nuclear-cytoplasmic shuttling when intracellular pH (pHi) changes, playing important roles in both the classical BMP signaling pathway and non-BMP signaling pathways. Given that Smad5 can move intracellularly in response to changes in physicochemical properties, its cellular localization may play a crucial role in the development of respiratory diseases. This article will explore the possibility that its distribution characteristics may be an important factor that is easily overlooked and not adequately considered in disease research.",
- "Predictions": [
- "Chronic respiratory disease"
+ "RNA, Circular"
],
- "MeshTerms": [
- "Humans",
- "Signal Transduction",
- "Animals",
- "Smad5 Protein",
- "Respiratory Tract Diseases"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39570415",
- "Title": "European journal of nutrition",
- "ArticleTitle": "Composite dietary antioxidant index, chronic respiratory disease, and all-cause mortality: National Health and Nutrition Examination Survey, 2003-2018.",
- "Abstract": "Our findings indicate that high CDAI is a significant protective factor against CRD and all-cause mortality in the US population.",
+ "PMID": "39502059",
+ "Title": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
+ "ArticleTitle": "[Research Progress of Breath Sound Analysis for Common Respiratory Diseases in Children].",
+ "Abstract": "Breath sounds can reflect the physiological and pathological conditions of the lungs and airways.Due to the differences in acoustic characteristics of breath sounds between healthy children and those with different respiratory diseases,analyzing breath sounds may provide important information for the diagnosis and treatment of respiratory diseases in children.With the development of digital auscultation,children's breath sounds have gradully become a research focus.This article summarizes the recent research progress in breath sound analysis for the diagnosis and treatment of common respiratory diseases in children,offering reference for the research in related fields.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Nutrition Surveys",
- "Middle Aged",
- "Male",
- "Female",
- "Adult",
- "Aged",
- "Antioxidants",
- "Adolescent",
- "Child, Preschool",
- "Young Adult",
- "Aged, 80 and over",
- "Infant",
- "Chronic Disease",
"Child",
- "Diet",
- "United States",
+ "Respiratory Sounds",
"Respiratory Tract Diseases",
- "Risk Factors",
- "Mortality",
- "Respiration Disorders"
- ]
+ "Auscultation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "6"
+ }
},
{
- "PMID": "39570333",
- "Title": "International journal of biometeorology",
- "ArticleTitle": "The impact of diurnal temperature range on the risk of hospitalizations in a low-income setting: the case of the Central Coast of Vietnam.",
- "Abstract": "The study aims to evaluate the effects of diurnal temperature range (DTR) on all causes, cardiovascular and respiratory conditions in the Central Coast of Vietnam, a tropical, low-income region with high DTR exposure but limited research. Daily hospital admission data from the largest hospitals in three provinces were analyzed alongside meteorological data. A time-series analysis using a generalized linear distributed lag model was conducted to examine the non-linear DTR-hospitalization association. A random-effect meta-analysis using restricted maximum likelihood was performed to calculate the pooled effects across three provinces. Stratified analyses by gender, age, season and natural disaster occurrence were conducted to identify vulnerable subpopulations. The multi-province pooled effects indicated that a 1\u00a0\u00b0C increase in DTR raised the risk of hospitalizations for all causes and respiratory diseases by 1.5% [1.2-1.8%] and 0.5% [0.0-1.0%], at lag 0-6 days. The effects of DTR on cardiovascular diseases, as well as those stratified by subgroups, were not statistically significant. Additionally, DTR had a greater adverse effect during the dry season and in the presence of natural disaster. Females and the elderly were slightly more susceptible to respiratory admissions, while males and younger individuals had a higher risk of all-cause admissions due to greater DTR effects. DTR was an independent risk factor for the exacerbation of all and specific causes, particularly among the susceptible subgroups. The findings suggested that it is necessary to take preventive measures to protect these at-risk populations from the adverse effects of extreme DTR exposure.",
+ "PMID": "39391315",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Liquid-liquid phase separation: a new perspective on respiratory diseases.",
+ "Abstract": "Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Vietnam",
"Humans",
- "Hospitalization",
- "Male",
- "Female",
- "Middle Aged",
- "Temperature",
- "Aged",
- "Adult",
- "Adolescent",
+ "Animals",
"Respiratory Tract Diseases",
- "Young Adult",
- "Infant",
- "Cardiovascular Diseases",
- "Child, Preschool",
- "Child",
- "Poverty",
- "Infant, Newborn",
- "Aged, 80 and over",
- "Risk"
- ]
+ "Liquid-Liquid Extraction",
+ "Signal Transduction",
+ "Phase Separation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39566943",
- "Title": "BMJ open",
- "ArticleTitle": "Features of causes of indirect certified disaster-related death in areas affected by the Fukushima Daiichi nuclear power plant accident: an observational study.",
- "Abstract": "To prevent indirect disaster-related deaths in the future, it is important to consider appropriate intervention methods by age group and period since disaster occurrence. It is especially important to improve the environment of evacuation shelters and establish a healthcare system for evacuees, create a system for cancer screening and treatment during evacuation and expand long-term suicide prevention measures.",
+ "PMID": "39370174",
+ "Title": "The Indian journal of tuberculosis",
+ "ArticleTitle": "Psychological comorbidities: Impact on respiratory health.",
+ "Abstract": "Respiratory diseases are commonly associated with mental health issues, which add to morbidity and mortality. However, this association has never received sufficient attention. There is an urgent need to sensitize the health care workers for early identification of psychological comorbidities, and their basic management. Mental health should be an integral part of the teaching curriculum. Simple, quick and easy to use screening questionnaires should be used on a routine basis for identifying stigma, psychological distress and poor health related quality of life. Psychiatrist should be a vital part of the multidisciplinary teams. Extensive collaborative research needs to be carried out in this field to devise clear-cut recommendations for day-to-day practise.",
"Predictions": [
- "Cancer",
"Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Mental Health"
],
"MeshTerms": [
"Humans",
- "Fukushima Nuclear Accident",
- "Japan",
- "Retrospective Studies",
- "Male",
- "Female",
- "Aged",
- "Middle Aged",
- "Adult",
- "Cause of Death",
- "Young Adult",
- "Adolescent",
- "Child",
- "Aged, 80 and over",
- "Child, Preschool",
- "Infant",
- "Disasters",
- "Earthquakes",
- "Respiratory Tract Diseases",
- "Cardiovascular Diseases",
- "Suicide",
- "Infant, Newborn",
- "Neoplasms"
- ]
+ "Comorbidity",
+ "Mental Disorders",
+ "Mental Health",
+ "Quality of Life",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39566532",
- "Title": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
- "ArticleTitle": "[Research progress on the role of exosomes in respiratory diseases].",
- "Abstract": "Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine. During the progression of respiratory tract diseases, exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins, disrupting the respiratory defense system and inducing or exacerbating the disease. Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases, which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections. The treatment of respiratory diseases is also closely related to exosomes. The low immunogenicity and high compatibility of exosomes make them effective tools for delivering molecules and drugs for treatment.",
+ "PMID": "39370173",
+ "Title": "The Indian journal of tuberculosis",
+ "ArticleTitle": "Psychological disorders in tuberculosis and respiratory diseases.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Exosomes",
"Humans",
- "Respiratory Tract Diseases",
- "Animals",
- "Biomarkers"
- ]
+ "Mental Disorders",
+ "Tuberculosis, Pulmonary",
+ "Tuberculosis",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39550655",
- "Title": "Recenti progressi in medicina",
- "ArticleTitle": "[Not Available].",
- "Abstract": "The River Sacco Basin (Rsb) is a site of National interest, characterized by several environmental pressures such as industrial facilities. This study investigates the association between long-term exposure to industrial-PM10 and -NOx and cause-specific mortality (non-accidental, cardiovascular, respiratory, and cancer) in the Rsb in the 2006-2018 period. We enrolled 301,681 residents near 14 major industrial plants (grouped into 5 30-km2 spatial domains). Residential exposure to annual PM10 and NOx was considered as categorical exposure (high (>80th percentile), medium (50th-80th), and low (<50th)). We applied adjusted domain specific Cox regression models (covariates: age, sex, and deprivation index) and performed a relative meta-analysis. We obtain a pooled 34% increase in respiratory mortality for high PM10 levels. Elevated risks were also observed for non-accidental and cancer mortality, highlighting the need for continuous monitoring and preventive interventions.",
+ "PMID": "39364938",
+ "Title": "The Veterinary record",
+ "ArticleTitle": "Managing respiratory cases during supply issues.",
+ "Abstract": "",
"Predictions": [
- "Cancer",
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
+ "Animals",
"Humans",
- "Male",
- "Female",
- "Particulate Matter",
- "Middle Aged",
- "Aged",
- "Adult",
- "Cohort Studies",
- "Environmental Exposure",
- "Respiratory Tract Diseases",
- "Neoplasms",
- "Air Pollution",
- "Air Pollutants",
- "Cardiovascular Diseases",
- "Italy",
- "Rivers",
- "Young Adult",
- "Proportional Hazards Models",
- "Manufacturing and Industrial Facilities",
- "Adolescent",
- "Cause of Death",
- "Industry",
- "Nitrogen Oxides",
- "Child, Preschool",
- "Aged, 80 and over"
- ]
+ "United Kingdom",
+ "Veterinary Medicine",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39544058",
- "Title": "Revue medicale suisse",
- "ArticleTitle": "[Volatile organic compounds and respiratory diseases].",
- "Abstract": "Our home is a place of refuge and protection, where we spend an average of 80 % of our time. Indoor air quality is an essential element that directly influences the health and well-being of individuals. The main sources of indoor pollution are human activity, which releases not only fine particles and carbon monoxide, but also volatile organic compounds (VOCs). A growing number of studies show a relationship between respiratory pathologies such as chronic obstructive pulmonary disease, asthma or Sick Building Syndrome, and exposure to VOCs. The aim of this article is to explore the relationship between VOCs and respiratory diseases, as well as the strategies to prevent their effect on health.",
+ "PMID": "39293035",
+ "Title": "Pediatric allergy, immunology, and pulmonology",
+ "ArticleTitle": "Pharmaceutical Therapies for Pediatric Respiratory Disease: Setbacks and Progress in 2024.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Volatile Organic Compounds",
- "Air Pollution, Indoor",
- "Pulmonary Disease, Chronic Obstructive",
+ "Child",
"Respiratory Tract Diseases",
- "Asthma",
- "Sick Building Syndrome"
- ]
+ "Pediatrics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "18"
+ }
},
{
- "PMID": "39543369",
- "Title": "Molecular psychiatry",
- "ArticleTitle": "Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis.",
- "Abstract": "People with bipolar disorder (BD) have an increased risk of premature mortality and the respiratory mortality rate is higher than those of the general population. To date, however, the evidence on respiratory disease in this population has not been meta-analyzed. We systematically review and meta-analyze the frequency of respiratory diseases in patients with BD and to compare prevalence and odds ratio (OR) with the general population. The systematic literature search was conducted in Pubmed, PsycINFO, Scielo and Scopus, with snowball search of reference and citation lists. Inclusion criteria were studies reporting diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer and tuberculosis) in people with BD according to operationalized criteria and where possible, control group. Of the 2158 articles screened, 20 including 962,352 people with BD and 37,340,405 control group, met the inclusion criteria. In people with BD, the prevalence of COPD was 9.14% (95%CI: 6.61-12.5%), asthma 6.4% (95%CI: 4.56-8.91%), pneumonia 2.78% (95%CI: 2.51-3.08%) and lung cancer 0.44% (95%CI:0.23-0.84%). Compared to the general population, people with BD had significantly higher rates of COPD (OR: 1.73; 95% CI: 1.40-2.14), showing an increased rate in younger and female patients; asthma (OR: 1.91, 95% CI: 1.25-2.94), with a greater rate in younger patients; and pneumonia (OR: 2.82, 95% CI: 1.33-5.99). In the first meta-analysis on the topic, BD was associated with an increased risk of respiratory illness versus the general population. In COPD and asthma, young people and women are at particular risk. Prevention programs are urgently needed.",
+ "PMID": "39176766",
+ "Title": "Studies in health technology and informatics",
+ "ArticleTitle": "Pre-Pilot Usability Study of the Take-A-Breath Project: A Personalized Platform for Respiratory Disease Management.",
+ "Abstract": "This study aims to evaluate the patient's platform of the Take-A-Breath project-a Greek project for personalized respiratory disease support. The pre-pilot usability study, involving 11 participants, employed a mixed-methods approach. While calculated scores indicate overall acceptance, concerns are identified, particularly regarding the learning curve needed for the guided inhalation feature, the application's core functionality. Users appreciate the feature's utility and design after repeated use. Findings recommend user manuals and healthcare professional training, providing essential insights for the upcoming RCT.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Bipolar Disorder",
- "Pulmonary Disease, Chronic Obstructive",
- "Asthma",
- "Prevalence",
- "Female",
- "Respiratory Tract Diseases",
- "Lung Neoplasms",
+ "Pilot Projects",
+ "Greece",
"Male",
- "Pneumonia",
- "Odds Ratio",
- "Respiration Disorders",
- "Risk Factors"
- ]
+ "Precision Medicine",
+ "Mobile Applications",
+ "User-Computer Interface",
+ "Female",
+ "Adult",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39537245",
- "Title": "European respiratory review : an official journal of the European Respiratory Society",
- "ArticleTitle": "Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications.",
- "Abstract": "Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30-150\u2005nm), microvesicles (sized 50-1000\u2005nm) and apoptotic bodies (sized 500-2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.",
+ "PMID": "39175108",
+ "Title": "Physiological reports",
+ "ArticleTitle": "Impact of environmental air pollution on respiratory health and function.",
+ "Abstract": "Environmental air pollution presents a considerable risk to global respiratory health. If critical levels are exceeded, inhaled pollutants can lead to the development of respiratory dysfunction and provoke exacerbation in those with pre-existing chronic respiratory disease. Over 90% of the global population currently reside in areas where environmental air pollution is considered excessive-with adverse effects ranging from acute airway irritation to complex immunomodulatory alterations. This narrative review provides an up-to-date perspective concerning the impact of environmental air pollution on respiratory health and function and describes the underpinning mechanisms that contribute to the development and progression of chronic respiratory disease.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Cell Communication",
- "Extracellular Vesicles",
+ "Air Pollution",
+ "Air Pollutants",
+ "Respiratory Tract Diseases",
"Animals",
- "Lung",
- "Lung Diseases",
- "Signal Transduction",
- "Respiratory Tract Diseases"
- ]
+ "Environmental Exposure"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39530346",
- "Title": "Epidemiologia e prevenzione",
- "ArticleTitle": "[Personal protection strategies for mitigating the effects of air pollution: A narrative literature review].",
- "Abstract": "this narrative review provides an overview of personal strategies capable of reducing air pollution exposure and consequently mitigating its negative impact on health. These findings can support the development of recommendations and communication and prevention interventions, promoting risk reduction policies and increased awareness and engagement from both healthcare and non-healthcare networks at the local level. Although more robust systematic approaches are needed, this review serves as a useful tool for stakeholders and citizens, while also providing a simple instrument with significant communicative potential, applicable on a large scale.",
+ "PMID": "39174416",
+ "Title": "Revue des maladies respiratoires",
+ "ArticleTitle": "[Respiratory oscillometry: Theoretical foundations and clinical applications].",
+ "Abstract": "Oscillometry measures the mechanical properties of the respiratory system. As they are carried out during spontaneous breathing, oscillometry measurements do not require forced breathing maneuvers or the patient's active cooperation. The technique is complementary to conventional pulmonary function testing methods for the investigation of respiratory function, diagnosis and monitoring of respiratory diseases, and assessment of response to treatment. The present review aims to describe the theoretical foundations and practical methodology of oscillometry. It describes the gaps in scientific evidence regarding its clinical utility, and provides examples of current research and clinical applications.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Air Pollution",
- "Environmental Exposure",
- "Cardiovascular Diseases",
+ "Oscillometry",
+ "Respiratory Function Tests",
"Respiratory Tract Diseases",
- "Environmental Monitoring",
- "Air Filters",
- "Child",
- "Exercise",
- "Aged",
- "Air Pollutants",
- "Masks"
- ]
+ "Respiration Disorders",
+ "Respiration"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39521464",
- "Title": "BMJ open",
- "ArticleTitle": "Nepal Family Cohort study: a study protocol.",
- "Abstract": "Findings will be disseminated through traditional academic pathways, including peer-reviewed publications and conference presentations. We will also engage the study population and local media (ie, research blogs and dissemination events) and prepare research and policy briefings for stakeholders and leaders at the local, provincial and national levels.",
+ "PMID": "39153858",
+ "Title": "Thorax",
+ "ArticleTitle": "Untangling the web between menopause and respiratory disease.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Nepal",
- "Child",
- "Risk Factors",
"Female",
- "Research Design",
- "Male",
- "Longitudinal Studies",
- "Adult",
- "Adolescent",
- "Parents",
- "Child, Preschool",
- "Air Pollution",
- "Respiratory Tract Diseases",
- "Cohort Studies",
- "Life Style",
- "Environmental Exposure"
- ]
+ "Menopause",
+ "Risk Factors",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "18"
+ }
},
{
- "PMID": "39515807",
- "Title": "Allergologia et immunopathologia",
- "ArticleTitle": "Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases.",
- "Abstract": "Respiratory diseases in children are common health problems that significantly impact their quality of life and health status, and this has its own unique challenges compared to adults. A growing body of research has focused on epigenetic mechanisms that relate with the development of various diseases, such as pediatric respiratory diseases. Noncoding RNAs (ncRNAs), especially long noncoding RNAs, microRNA, and circular RNA, are reported to play a regulatory role in pediatric respiratory diseases whose mutations or aberrant expressions are strongly associated with the development of these diseases. In this review, we mainly discussed the functions of these three ncRNAs in pediatric respiratory diseases.",
+ "PMID": "39069319",
+ "Title": "Clinics in chest medicine",
+ "ArticleTitle": "Outdoor Air Pollution and Pediatric Respiratory Disease.",
+ "Abstract": "Outdoor air pollution is ubiquitous, and no safe level of exposure has been identified for the most common air pollutants such as ozone and particle pollution. Children are uniquely more susceptible to the harms of outdoor air pollution, which can cause and exacerbate respiratory disease. Although challenging to identify the effects of outdoor air pollution on individual patients, understanding the basics of outdoor air pollution is essential for pediatric respiratory health care providers. This review covers basic information regarding outdoor air pollution, unique considerations for children, mechanisms for increased susceptibility, and association with incident and exacerbation of respiratory disease in children.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
+ "Air Pollution",
"Child",
- "RNA, Untranslated",
- "RNA, Long Noncoding",
- "Epigenesis, Genetic",
- "MicroRNAs",
"Respiratory Tract Diseases",
- "RNA, Circular"
- ]
- },
- {
- "PMID": "39513278",
- "Title": "Journal of global health",
- "ArticleTitle": "Dysregulated blood biomarkers in women with acute and chronic respiratory conditions due to air pollutant exposure: An exploratory systematic review.",
- "Abstract": "PROSPERO: 42023435721.",
- "Predictions": [
- "Chronic respiratory disease"
- ],
- "MeshTerms": [
- "Humans",
- "Biomarkers",
- "Female",
"Air Pollutants",
- "Respiratory Tract Diseases",
- "Chronic Disease",
"Environmental Exposure",
- "Air Pollution",
- "Acute Disease"
- ]
+ "Particulate Matter",
+ "Ozone"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "29"
+ }
},
{
- "PMID": "39505076",
- "Title": "Chemosphere",
- "ArticleTitle": "Spatial associations of daily PM",
- "Abstract": "Air pollution, particularly fine particulate matter less than 2.5\u00a0\u03bcm in diameter (PM",
+ "PMID": "39054045",
+ "Title": "British journal of sports medicine",
+ "ArticleTitle": "Infographic. International Olympic Committee (IOC) consensus statement and clinical decision-making guide on acute respiratory illness in athletes.",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Particulate Matter",
- "Republic of Korea",
- "Cardiovascular Diseases",
"Humans",
- "Air Pollutants",
- "Air Pollution",
- "Hospitalization",
- "Environmental Exposure",
+ "Consensus",
+ "Clinical Decision-Making",
+ "Sports Medicine",
+ "Athletes",
+ "Acute Disease",
+ "Sports",
"Respiratory Tract Diseases",
- "Aged"
- ]
+ "Practice Guidelines as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "26"
+ }
},
{
- "PMID": "39503908",
- "Title": "International archives of occupational and environmental health",
- "ArticleTitle": "Impact of extreme bushfire seasons on rates of occupational injury and disease compensation claims in first responders.",
- "Abstract": "Extreme bushfire events were associated with increased mental claims rates in all FR, with the highest in firefighters. Strategies to better prevent and manage injury/disease risk in FR are urgently required, particularly for mental health conditions.",
+ "PMID": "39031147",
+ "Title": "The Veterinary record",
+ "ArticleTitle": "Staphylococcus aureus causing respiratory disease and mastitis in sheep.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Male",
+ "Animals",
+ "Sheep",
+ "Sheep Diseases",
+ "Staphylococcal Infections",
"Female",
- "Adult",
- "Occupational Injuries",
- "Workers' Compensation",
- "Seasons",
- "Middle Aged",
- "Occupational Diseases",
- "Emergency Responders",
- "Mental Disorders",
- "Firefighters",
- "Victoria",
- "Musculoskeletal Diseases",
- "Wildfires",
+ "Mastitis",
+ "Staphylococcus aureus",
+ "Cattle",
+ "Cattle Diseases",
+ "Swine",
+ "Swine Diseases",
+ "Sentinel Surveillance",
+ "United Kingdom",
"Respiratory Tract Diseases",
- "Young Adult",
- "Police"
- ]
+ "Poultry Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "20"
+ }
},
{
- "PMID": "39502059",
- "Title": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
- "ArticleTitle": "[Research Progress of Breath Sound Analysis for Common Respiratory Diseases in Children].",
- "Abstract": "Breath sounds can reflect the physiological and pathological conditions of the lungs and airways.Due to the differences in acoustic characteristics of breath sounds between healthy children and those with different respiratory diseases,analyzing breath sounds may provide important information for the diagnosis and treatment of respiratory diseases in children.With the development of digital auscultation,children's breath sounds have gradully become a research focus.This article summarizes the recent research progress in breath sound analysis for the diagnosis and treatment of common respiratory diseases in children,offering reference for the research in related fields.",
+ "PMID": "39004092",
+ "Title": "The Lancet. Respiratory medicine",
+ "ArticleTitle": "Treating acute respiratory illness: the need to be proactive.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Child",
- "Respiratory Sounds",
- "Respiratory Tract Diseases",
- "Auscultation"
- ]
+ "Acute Disease",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "15"
+ }
},
{
- "PMID": "39494780",
- "Title": "The British journal of nutrition",
- "ArticleTitle": "Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?",
- "Abstract": "The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother\u2013child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5\u00b75 years were considered jointly through five allergic and respiratory multimorbidity clusters (\u2018asymptomatic\u2019 - reference, \u2018early wheeze without asthma\u2019, \u2018asthma only\u2019, \u2018allergies without asthma\u2019 and \u2018multi-allergic\u2019). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the \u2018early wheeze without asthma\u2019 cluster (aOR (95 % CI) = 0\u00b795 (0\u00b790, 0\u00b799) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the \u2018asthma only\u2019 cluster (aOR (95 % CI) = 1\u00b709 (1\u00b700, 1\u00b719) per sd). No association was found with the \u2018allergies without asthma\u2019 or \u2018multi-allergic\u2019 clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5\u00b75 years, though the associations were weak.",
+ "PMID": "38996473",
+ "Title": "The Lancet. Respiratory medicine",
+ "ArticleTitle": "Fasting in Ramadan and respiratory diseases.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Female",
- "Pregnancy",
- "Antioxidants",
- "Diet",
- "Hypersensitivity",
- "Child, Preschool",
- "Inflammation",
- "Male",
- "Birth Cohort",
- "Multimorbidity",
- "Adult",
- "Maternal Nutritional Physiological Phenomena",
- "Infant",
- "Respiratory Tract Diseases",
- "Asthma",
- "Prenatal Exposure Delayed Effects",
- "Cohort Studies"
- ]
+ "Fasting",
+ "Islam",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "13"
+ }
},
{
- "PMID": "39494537",
- "Title": "Current opinion in supportive and palliative care",
- "ArticleTitle": "Education for people with serious chronic respiratory diseases and their informal caregivers: how to address challenges that impact learning.",
- "Abstract": "Learner-centered education may enhance knowledge acquisition in people with serious chronic respiratory diseases and their informal caregivers aiming to gain control over symptoms and optimize shared decision making and advance care planning.",
+ "PMID": "38995592",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Caregivers",
"Chronic Disease",
- "Patient Education as Topic",
- "Health Literacy",
- "Palliative Care",
- "Advance Care Planning",
- "Decision Making, Shared",
- "Learning",
+ "Influenza Vaccines",
+ "Pneumococcal Vaccines",
+ "Pulmonary Disease, Chronic Obstructive",
"Respiratory Tract Diseases",
- "Health Knowledge, Attitudes, Practice",
- "Adaptation, Psychological",
- "Decision Making"
- ]
+ "Vaccination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "12"
+ }
},
{
- "PMID": "39494092",
- "Title": "International journal of public health",
- "ArticleTitle": "Long-Term Exposure to Nitrogen Dioxide and Ozone and Mortality: Update of the WHO Air Quality Guidelines Systematic Review and Meta-Analysis.",
- "Abstract": "An increasing body of evidence, with new results from countrywide areas and the Western Pacific, supports certainty, including new outcomes.",
+ "PMID": "38988120",
+ "Title": "Biomedical and environmental sciences : BES",
+ "ArticleTitle": "Health Effects of Extreme Low Temperatures and Cold Waves on Respiratory Diseases.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Air Pollutants",
- "Air Pollution",
- "Environmental Exposure",
- "Europe",
- "Nitrogen Dioxide",
- "Ozone",
"Respiratory Tract Diseases",
- "World Health Organization"
- ]
+ "Cold Temperature",
+ "Extreme Cold"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "11"
+ }
},
{
- "PMID": "39493756",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Idbview: a database and interactive platform for respiratory-associated disease.",
- "Abstract": "Public databases have become invaluable resources for disease research, particularly in the realm of identifying and validating biomarkers, thus playing a significant role in enhancing our understanding of respiratory diseases. To facilitate this understanding, the development of user-friendly analytical tools and advanced systematic models that leverage the growing omics data and clinical information datasets is essential. Despite the importance of such resources, the research progress related to respiratory diseases is hindered by the absence of a centralized platform housing easily accessible datasets and accompanying visualization tools. In an effort to streamline and standardize information sharing across diverse respiratory research initiatives, we introduce Idbview, a specialized digital database focusing on respiratory conditions, offering interactive visualization functionalities powered by both Vue and R Shiny applications. Idbview brings together clinical data and various omics datasets, serving as a centralized repository, while also providing users with a suite of interactive tools to analyze and visualize data from multiple perspectives. As a comprehensive resource hub, Idbview aims to support the research community in conducting further studies in both clinical and bioinformatics domains, with the website accessible at https://idbview.com.",
+ "PMID": "38954452",
+ "Title": "British journal of nursing (Mark Allen Publishing)",
+ "ArticleTitle": "Assessment and examination of the respiratory system.",
+ "Abstract": "This article aims to outline the fundamental principles of consultations with and clinical assessments of patients with symptoms that may be indicative of respiratory system pathology. The article explores how to perform a respiratory system-focused patient history and physical examination. An evaluation of clinical 'red flags' to reduce the risk of omitting serious illness is also considered, alongside the exploration of features of respiratory pathology and evidence-based clinical decision-making tools that may be used to support clinical diagnosis.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Computational Biology",
- "User-Computer Interface",
- "Databases, Factual",
+ "Physical Examination",
"Respiratory Tract Diseases",
- "Software"
- ]
+ "Medical History Taking",
+ "Nursing Assessment",
+ "Respiratory System"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "2"
+ }
},
{
- "PMID": "39489274",
- "Title": "Environmental research",
- "ArticleTitle": "Associations between various types of mortality and temperature variability distinguishing the intraday and interday effects in South Korea.",
- "Abstract": "This study provided evidence on the season-stratified, independent impacts of intraday and interday temperature variabilities on total, age-specific, gender-specific, and cause-specific mortality risks in South Korea drawing attention to the need of targeted policies to alleviate the impacts on human health.",
+ "PMID": "38924193",
+ "Title": "Respirology (Carlton, Vic.)",
+ "ArticleTitle": "Respiratory teletrials-A call for equitable access to clinical trials for people with respiratory conditions.",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Republic of Korea",
"Humans",
- "Female",
- "Male",
- "Temperature",
- "Middle Aged",
- "Seasons",
- "Aged",
- "Cardiovascular Diseases",
- "Mortality",
- "Adult",
- "Child",
- "Adolescent",
- "Child, Preschool",
- "Young Adult",
- "Infant",
- "Aged, 80 and over",
+ "Clinical Trials as Topic",
"Respiratory Tract Diseases",
- "Infant, Newborn"
- ]
+ "Health Services Accessibility"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "26"
+ }
},
{
- "PMID": "39477760",
- "Title": "Medicina clinica",
- "ArticleTitle": "Trends in mortality in Spain, with a special focus on respiratory-related conditions in the midst of the COVID-19 pandemic.",
- "Abstract": "Despite overall mortality returning to pre-pandemic levels, this study highlights a significant increase in respiratory disease deaths in Spain in 2022 compared to 2019.",
+ "PMID": "38910578",
+ "Title": "Future medicinal chemistry",
+ "ArticleTitle": "Exploring the current advancements of quercetin nanoformulations alleviating respiratory diseases.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Quercetin",
"Humans",
- "Spain",
- "COVID-19",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Adult",
- "Adolescent",
- "Young Adult",
- "Cause of Death",
- "Aged, 80 and over",
- "Child",
- "Child, Preschool",
- "Infant",
+ "Nanoparticles",
"Respiratory Tract Diseases",
- "Mortality",
- "Pandemics",
- "Infant, Newborn"
- ]
+ "Antioxidants"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "24"
+ }
},
{
- "PMID": "39472952",
- "Title": "Health and quality of life outcomes",
- "ArticleTitle": "An item bank to measure health-related quality of life among young children (0-5-years-old) affected by respiratory illnesses - expert stakeholders and end-users from the Western Cape, South Africa.",
- "Abstract": "An item bank was developed as a first step to develop a comprehensive disease-specific HRQoL tool for young children with respiratory illnesses in an LMIC. Input from caregivers and content experts was crucial in creating two HRQoL item banks tailored to the developmental differences between 0 and 2 and 3-5-year age groups. Their contributions ensured the tool effectively captures age-appropriate aspects of HRQoL. Future studies should focus on assessing the validity and reliability of these item banks.",
+ "PMID": "38856122",
+ "Title": "European review for medical and pharmacological sciences",
+ "ArticleTitle": "Reply letter to Adeli and Jazi - \"Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion\".",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "South Africa",
- "Quality of Life",
- "Child, Preschool",
- "Infant",
- "Male",
- "Female",
- "Delphi Technique",
- "Surveys and Questionnaires",
+ "Acetylcysteine",
+ "Mucus",
+ "Administration, Intravenous",
"Respiratory Tract Diseases",
- "Infant, Newborn",
- "Psychometrics",
- "Respiratory Tract Infections"
- ]
+ "Expectorants"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "10"
+ }
},
{
- "PMID": "39468133",
- "Title": "Scientific reports",
- "ArticleTitle": "Gastrointestinal and respiratory morbidity when introducing eggs as complementary food: a randomised controlled trial in South African infants.",
- "Abstract": "We investigated the incidence and duration of morbidity symptoms among infants aged 6 to 9 months from a low socioeconomic community receiving one egg daily for 6 months. This was a secondary outcome of a randomised controlled trial (RCT) of 500 infants conducted in Jouberton, South Africa. The primary outcome was linear growth. Morbidity data were collected weekly using a symptoms diary and qualitative data with focus group discussions at the endpoint. Ethical approval was obtained from the North-West University Health Research Ethics Committee. The intervention group had a\u2009~\u20095% higher incidence of gastrointestinal morbidity (17.0%) compared to the control group (11.9%). Gastrointestinal morbidity without fever tended to be 1.4 times higher in the intervention group (OR: 1.43, 95% CI: 1.03, 1.93; P\u2009=\u20090.058) and tended to be 4 times higher with fever (OR: 4.07, 95% CI: 0.86, 19.23; P\u2009=\u20090.077). The duration of total gastrointestinal and respiratory morbidity was 1.5 days longer in the intervention group (\u03b2: 1.491; 95% CI 0.064, 2.918; P\u2009=\u20090.041). Complementary feeding with eggs may have contributed towards an increased risk for gastrointestinal morbidity.",
+ "PMID": "38851194",
+ "Title": "The Lancet. Respiratory medicine",
+ "ArticleTitle": "Protecting respiratory health of athletes: an Olympic challenge.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Infant",
- "South Africa",
- "Female",
- "Male",
- "Eggs",
- "Gastrointestinal Diseases",
- "Infant Nutritional Physiological Phenomena",
- "Respiratory Tract Diseases",
- "Incidence",
- "Morbidity"
- ]
+ "Athletes",
+ "Sports",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "9"
+ }
},
{
- "PMID": "39466470",
- "Title": "Current allergy and asthma reports",
- "ArticleTitle": "Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases.",
- "Abstract": "BMP2 signaling pathway includes the canonical and non-canonical signaling pathway. The canonical signaling pathway is the BMP2-SMAD pathway, and the non-canonical signaling pathway includes mitogen-activated protein kinase (MAPK) pathway and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway. The BMP2 is related to pulmonary hypertension (PH), lung cancer, pulmonary fibrosis (PF), asthma, and chronic obstructive pulmonary disease (COPD). BMP2 inhibits the proliferation of pulmonary artery smooth muscle cells (PASMCs), promotes the apoptosis of PASMCs to reduce pulmonary vascular remodeling in PH, which is closely related to the canonical and non-canonical pathway. In addition, BMP2 stimulates the proliferation and migration of cells to promote the occurrence, colonization, and metastasis of lung cancer through the canonical and the non-canonical pathway. Meanwhile, BMP2 exert anti-fibrotic function in PF through canonical signaling pathway. Moreover, BMP2 inhibits airway inflammation to maintain airway homeostasis in asthma. However, the signaling pathways involved in asthma are poorly understood. BMP2 inhibits the expression of ciliary protein and promotes squamous metaplasia of airway epithelial cells to accelerate the development of COPD. In conclusion, BMP2 may be a therapeutic target for several respiratory diseases.",
+ "PMID": "38819980",
+ "Title": "JAMA",
+ "ArticleTitle": "Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications.",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease"
+ "Chronic respiratory disease",
+ "Diabetes type 2"
],
"MeshTerms": [
+ "Female",
"Humans",
- "Bone Morphogenetic Protein 2",
- "Signal Transduction",
- "Animals",
+ "Male",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon-Like Peptide-1 Receptor Agonists",
+ "Hypoglycemic Agents",
+ "Postoperative Complications",
"Respiratory Tract Diseases",
- "Lung Neoplasms",
- "Hypertension, Pulmonary"
- ]
+ "Risk",
+ "Preoperative Period"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "31"
+ }
},
{
- "PMID": "39465586",
- "Title": "COPD",
- "ArticleTitle": "Comorbidity Patterns in Chronic Obstructive Pulmonary Disease and Their Associations with Service Utilization.",
- "Abstract": "Common combinations of comorbidities among inpatients with COPD were identified from an extensive collection of discharge medical records. Furthermore, the associations between comorbidities, inpatient service usage, and readmission rates were determined.",
+ "PMID": "38819978",
+ "Title": "JAMA",
+ "ArticleTitle": "Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications.",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease"
+ "Chronic respiratory disease",
+ "Diabetes type 2"
],
"MeshTerms": [
+ "Female",
"Humans",
- "Pulmonary Disease, Chronic Obstructive",
"Male",
- "Female",
- "Aged",
- "Comorbidity",
- "Patient Readmission",
- "Length of Stay",
"Middle Aged",
- "Retrospective Studies",
- "Heart Failure",
- "Prospective Studies",
- "Hypertension",
- "Myocardial Ischemia",
- "Pulmonary Heart Disease",
- "Aged, 80 and over",
- "Prevalence",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon-Like Peptide-1 Receptor Agonists",
+ "Hypoglycemic Agents",
+ "Postoperative Complications",
+ "Risk",
+ "Preoperative Period",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "31"
+ }
},
{
- "PMID": "39462582",
- "Title": "Environmental health and preventive medicine",
- "ArticleTitle": "The effect modification of PM",
- "Abstract": "PM",
+ "PMID": "38816102",
+ "Title": "Clinics in chest medicine",
+ "ArticleTitle": "Imaging of Large Airway Disorders.",
+ "Abstract": "Large airway disorders encompass a large variety of diseases and pathology, with broad categories including anatomic variants, congenital abnormalities, acquired abnormalities, inflammatory/infiltrative causes, infection, and tumors. The most common diseases in each category are discussed with a focus on the salient imaging findings. Pitfalls to beware of are discussed through the article, and concludes with a general method to approaching large airways pathology that should provide the reader with a basic framework and understanding of this complex topic.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Ozone",
- "Japan",
- "Particulate Matter",
"Humans",
- "Air Pollutants",
- "Cities",
- "Aged",
- "Female",
- "Mortality",
- "Male",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Adult",
- "Air Pollution",
- "Hot Temperature",
- "Temperature",
+ "Tomography, X-Ray Computed",
"Respiratory Tract Diseases",
- "Environmental Exposure",
- "Young Adult",
- "Aged, 80 and over"
- ]
+ "Bronchial Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "31"
+ }
},
{
- "PMID": "39462039",
- "Title": "Scientific reports",
- "ArticleTitle": "Genetic evidence of bidirectional mendelian randomization study on the causality between gut microbiome and respiratory diseases contributes to gut-lung axis.",
- "Abstract": "Observational studies and clinical trials have suggested the relationship between the gut microbiome and respiratory diseases, but the causality between them remains unclear. Firstly, we selected eight respiratory diseases Genome-wide association study (GWAS) datasets mainly from the FinnGen collaboration as outcomes. The exposure was based on GWAS statistics about the gut microbiome, sourced from the MiBioGen consortium, including gut microbial taxa. The causal link between the gut microbiome and respiratory illnesses was then estimated using a Two-sample Mendelian randomization (MR) analysis, including the inverse-variance weighted (IVW), weighted median, MR-Egger, simple mode, and weighted mode. To ensure reliability, F-statistics and sensitivity tests were conducted. Furthermore, we performed a reverse MR analysis of the pre-Mendelian positive findings to possible reverse causality. For the 196 gut microbe taxa, the IVW analysis suggested 88 potential associations with eight clinically prevalent respiratory diseases. Among them, 30 causal associations were found in more than one MR method. Multiple statistical corrections have confirmed three causal associations: genus Holdemanella was a risk factor for chronic obstructive pulmonary disease (COPD) (P\u2009=\u20091.3\u2009\u00d7\u200910",
+ "PMID": "38763886",
+ "Title": "Zhonghua er ke za zhi = Chinese journal of pediatrics",
+ "ArticleTitle": "[Application of cardiopulmonary exercise test in children with respiratory system diseases].",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Mendelian Randomization Analysis",
- "Gastrointestinal Microbiome",
- "Genome-Wide Association Study",
- "Lung",
+ "Exercise Test",
+ "Child",
+ "Oxygen Consumption",
+ "Cystic Fibrosis",
"Respiratory Tract Diseases",
- "Risk Factors"
- ]
+ "Hypertension, Pulmonary",
+ "Exercise Tolerance",
+ "Bronchopulmonary Dysplasia",
+ "Dyspnea",
+ "Anaerobic Threshold",
+ "Lung Diseases, Interstitial",
+ "Respiratory Function Tests"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "20"
+ }
},
{
- "PMID": "39457304",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "Respiratory Symptoms and Paper Dust Exposure among Workers in the Paper Industry in Ethiopia: A Comparative Cross-Sectional Study.",
- "Abstract": "Chronic respiratory symptoms are a health concern in the paper industry. This study evaluates the association between personal inhalable paper dust exposure and chronic respiratory symptoms among workers in this industry. In total, 270 workers from the paper industry and 267 from a water bottling factory participated. Chronic respiratory symptoms were assessed using a standardized questionnaire, modified from the American Thoracic Society. A job exposure matrix, based on cross-sectional personal measurements of inhalable paper dust, was used to estimate the exposure-response relationship between cumulative dust exposure and chronic respiratory symptoms. There was a higher prevalence of chronic coughs (27.4% vs. 7.5%), breathlessness (25.6% vs. 11%), coughs with sputum (21.1% vs. 1.1%), and wheezing (25.6% vs. 5%) among paper workers compared to those in the water bottling industry. A Poisson regression analysis revealed that the prevalence ratios for chronic coughs (APR = 3.3 and 95% CI: 2.0-5.4), breathlessness (APR = 2.2 and 95% CI: 1.4-3.4), and wheezing (APR = 4.3 and 95% CI: 2.3-7.7) were significantly higher in paper workers than in water bottling workers. Among paper workers, a significant exposure-response relationship was observed between cumulative dust exposure and chronic coughs after adjusting for age, sex, history of respiratory illnesses, work in other dusty industries, and use of biofuels. As there were only four ever-smokers, smoking was not included in the regression analysis. The results show a significant association between dust exposure and coughing, highlighting the need for control measures to prevent the development of respiratory symptoms among workers.",
+ "PMID": "38760170",
+ "Title": "Thorax",
+ "ArticleTitle": "Availability, cost and affordability of essential medicines for chronic respiratory diseases in low-income and middle-income countries: a cross-sectional study.",
+ "Abstract": "Contemporary data on the availability, cost and affordability of essential medicines for chronic respiratory diseases (CRDs) across low-income and middle-income countries (LMICs) are missing, despite most people with CRDs living in LMICs. Cross-sectional data for seven CRD medicines in pharmacies, healthcare facilities and central medicine stores were collected from 60 LMICs in 2022-2023. Medicines for symptomatic relief were widely available and affordable, while preventative treatments varied widely in cost, were less available and largely unaffordable. There is an urgent need to address these issues if the Sustainable Development Goal 3 is to be achieved for people with asthma by 2030.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
"Cross-Sectional Studies",
- "Dust",
- "Adult",
- "Male",
- "Occupational Exposure",
- "Ethiopia",
- "Female",
- "Paper",
- "Middle Aged",
- "Cough",
- "Prevalence",
- "Young Adult",
+ "Developing Countries",
+ "Drugs, Essential",
+ "Chronic Disease",
+ "Health Services Accessibility",
+ "Drug Costs",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "38742192",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "A comprehensive meta-analysis on safety outcomes reveals the novel potentials of SGLT2is, especially preventing respiratory diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Diabetes Mellitus, Type 2",
+ "Respiration Disorders",
"Respiratory Tract Diseases",
- "Respiratory Sounds",
- "Surveys and Questionnaires",
- "Occupational Diseases",
- "Industry",
- "Dyspnea",
- "Air Pollutants, Occupational"
- ]
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "14"
+ }
},
{
- "PMID": "39453518",
- "Title": "International journal of biometeorology",
- "ArticleTitle": "The interactive effect of extreme weather events and PM",
- "Abstract": "With climate change posing increasing threats and aging populations, understanding the complex relationship between extreme temperatures, PM",
+ "PMID": "38726611",
+ "Title": "Nutricion hospitalaria",
+ "ArticleTitle": "[What is requested by the specialist in respiratory pathology].",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Particulate Matter",
- "Aged",
- "Female",
- "Male",
- "Cross-Over Studies",
- "Altitude",
- "Air Pollutants",
- "Respiratory Tract Diseases",
- "China",
- "Extreme Weather",
- "Aged, 80 and over",
- "Middle Aged",
- "Cities",
- "Air Pollution"
- ]
+ "Pulmonary Medicine",
+ "Specialization",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "10"
+ }
},
{
- "PMID": "39444957",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Impacts from air pollution on respiratory disease outcomes: a meta-analysis.",
- "Abstract": "Our study supports associations between air pollutants, including non-exhaust trace metals, and respiratory outcomes across different age groups. The findings underscore the need for stringent environmental health policies and further research, especially in regions with higher pollution levels. The future studies should consider long-term and short-term exposures separately and include diverse populations to improve the accuracy and generalizability of the results.",
+ "PMID": "38662376",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Exposure to Burn Pit Emissions and Respiratory Diseases?",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Adolescent",
- "Adult",
- "Child",
"Humans",
"Air Pollutants",
"Air Pollution",
"Environmental Exposure",
- "Particulate Matter",
+ "Open Waste Burning",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "25"
+ }
},
{
- "PMID": "39444118",
- "Title": "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi",
- "ArticleTitle": "[Association of solid fuel use for heating and smoking with respiratory diseases: a prospective cohort study].",
- "Abstract": {
- "b": "Conclusions:",
- "i": "CI"
- },
+ "PMID": "38650380",
+ "Title": "Respirology (Carlton, Vic.)",
+ "ArticleTitle": "Exhaled biomarkers for respiratory diseases.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Middle Aged",
- "Heating",
- "Prospective Studies",
- "Female",
- "Male",
- "Respiratory Tract Diseases",
- "Proportional Hazards Models",
- "China",
- "Smoking",
- "Risk Factors",
- "Adult",
- "Air Pollution, Indoor"
- ]
+ "Biomarkers",
+ "Breath Tests",
+ "Exhalation",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "23"
+ }
},
{
- "PMID": "39443904",
- "Title": "Environmental health : a global access science source",
- "ArticleTitle": "A co-created citizen science project on the short term effects of outdoor residential woodsmoke on the respiratory health of adults in the Netherlands.",
- "Abstract": "Adults experienced more SOB during rest, nasal symptoms and used more medication to treat respiratory symptoms on days with higher levels of outdoor woodsmoke concentrations.",
+ "PMID": "38648036",
+ "Title": "JAMA",
+ "ArticleTitle": "Preoperative GLP-1 Receptor Agonist Use and Risk of Postoperative Respiratory Complications.",
+ "Abstract": "",
"Predictions": [
- "Chronic respiratory disease"
+ "Chronic respiratory disease",
+ "Diabetes type 2"
],
"MeshTerms": [
- "Humans",
- "Netherlands",
"Female",
+ "Humans",
"Male",
- "Adult",
"Middle Aged",
- "Smoke",
- "Wood",
- "Air Pollutants",
- "Environmental Exposure",
- "Aged",
- "Particulate Matter",
+ "Diabetes Mellitus, Type 2",
+ "Hypoglycemic Agents",
+ "Postoperative Complications",
+ "Risk",
"Respiratory Tract Diseases",
- "Glucose"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists",
+ "Withholding Treatment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "22"
+ }
},
{
- "PMID": "39439241",
- "Title": "Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen",
- "ArticleTitle": "Breathing time: a longue-dur\u00e9e multidisciplinary study of respiratory illnesses and airborne diseases in Switzerland (16",
- "Abstract": "This research is the first of its kind to assess of the impact of respiratory illnesses and airborne diseases (acronymized as \"RIAD\" hereafter) on Swiss mortality in the long run, between the 16",
+ "PMID": "38622023",
+ "Title": "Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery",
+ "ArticleTitle": "[Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease: a case report].",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Switzerland",
"Humans",
- "History, 20th Century",
- "History, 21st Century",
- "History, 17th Century",
- "History, 16th Century",
- "Respiratory Tract Diseases",
- "Male",
- "Female",
- "History, 18th Century",
- "History, 19th Century",
- "Adult",
- "Middle Aged",
+ "Anti-Inflammatory Agents, Non-Steroidal",
"Respiration Disorders",
- "Aged",
- "Child",
- "Adolescent",
- "Air Pollution"
- ]
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "16"
+ }
},
{
- "PMID": "39436432",
- "Title": "International archives of occupational and environmental health",
- "ArticleTitle": "Air quality disparities and respiratory health risks in critically polluted and relatively non-polluted areas: a prospective child health study.",
- "Abstract": "This research underscores the pressing need to address air pollution in critically polluted areas and its profound effects on children's respiratory health. Public health interventions, such as reducing emissions from industries and creating green spaces, should be prioritized. Furthermore, early respiratory health screening in schools within polluted areas could aid in the timely diagnosis and management of respiratory issues in children.",
+ "PMID": "38599818",
+ "Title": "Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases",
+ "ArticleTitle": "[Primary antibody deficiencies and respiratory manifestations in adults].",
+ "Abstract": "Primary antibody deficiencies (PAD) are a group of congenital disorders caused by genetic defects that affect the development and function of the body's immune defence mechanisms. Patients with PAD may present with recurrent infections, lymphoproliferation, autoimmune diseases, autoinflammation, or malignancies. Respiratory system manifestations may include bronchiectasis, bronchial asthma, and interstitial lung disease, among others. A comprehensive understanding of PADs will help to distinguish these covert cases from more common respiratory diseases.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Adult",
"Humans",
- "Prospective Studies",
- "Child",
+ "Bronchiectasis",
"Respiratory Tract Diseases",
- "Male",
- "Female",
- "Air Pollutants",
- "Particulate Matter",
- "Air Pollution",
- "Child Health",
- "Environmental Exposure",
- "Air Pollution, Indoor",
- "Adolescent",
- "Environmental Monitoring"
- ]
+ "Autoimmune Diseases",
+ "Asthma",
+ "Primary Immunodeficiency Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "11"
+ }
},
{
- "PMID": "39435892",
- "Title": "Epidemiology (Cambridge, Mass.)",
- "ArticleTitle": "Long-term Associations Between Time-varying Exposure to Ambient PM 2.5 and Mortality: An Analysis of the UK Biobank.",
- "Abstract": "We found associations of long-term PM 2.5 exposure with all-cause, nonaccidental, respiratory, and lung cancer mortality, but not with cardiovascular mortality. This study benefits from finely reconstructed time-varying exposures and extensive control for confounding, further supporting a plausible causal link between long-term PM 2.5 and mortality.",
+ "PMID": "38546004",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "Pediatric pulmonology year in review 2023: Physiology.",
+ "Abstract": "Application of the principles of pulmonary physiology and lung development to the care and management of respiratory disease in children is a distinguishing feature of pediatric pulmonology. In 2023, this was evident in numerous publications in Pediatric Pulmonology and other journals. This review will highlight some of the papers in this area.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "United Kingdom",
- "Particulate Matter",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Proportional Hazards Models",
- "Environmental Exposure",
- "Cardiovascular Diseases",
- "Biological Specimen Banks",
- "Mortality",
- "Time Factors",
- "Air Pollution",
- "Air Pollutants",
- "Adult",
- "Cohort Studies",
- "Machine Learning",
- "Respiratory Tract Diseases",
- "UK Biobank"
- ]
+ "Pulmonary Medicine",
+ "Child",
+ "Pediatrics",
+ "Lung",
+ "Lung Diseases",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "28"
+ }
},
{
- "PMID": "39434079",
- "Title": "BMC public health",
- "ArticleTitle": "The construction and validity assessment of the respiratory air quality health index (AQHI) based on the analytic hierarchy process in Tianjin, China.",
- "Abstract": "This study indicated that compared with AQI, the constructed AQHI based on AHP may predict the health risk of air pollution more effectively. AHP may become a new method to construct AQHI which needs to be proved by taking into consideration by more studies.",
+ "PMID": "38484266",
+ "Title": "Pediatric allergy, immunology, and pulmonology",
+ "ArticleTitle": "Artificial Intelligence in Pediatric Respiratory Diseases: Current Status and Future Promises.",
+ "Abstract": "",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Child",
"Humans",
- "China",
- "Air Pollution",
- "Respiratory Tract Diseases",
- "Risk Assessment",
- "Air Pollutants",
- "Reproducibility of Results"
- ]
+ "Artificial Intelligence",
+ "Forecasting",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "14"
+ }
},
{
- "PMID": "39424664",
- "Title": "Scientific reports",
- "ArticleTitle": "Assessing the impact of meteorological factors and air pollution on respiratory disease mortality rates: a random forest model analysis (2017-2021).",
- "Abstract": "Air pollution poses a significant threat to the health of all living beings on our planet. It has been scientifically established as a crucial factor affecting mortality rates, respiratory illnesses, mental well-being, and overall health. This study aimed to investigate the impact of air pollution and meteorological factors on respiratory disease mortality rates in Mashhad in 2017-2021 using a Random Forest (RF) model. At first, the daily statistics of meteorological parameters (pressure, humidity, temperature, solar radiation) during 2017-2021 were collected. The information related to pollutants pollutants such as PM",
+ "PMID": "37987432",
+ "Title": "Ugeskrift for laeger",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "Hydrofluorocarbons, the propellants used in metered dose inhalers, are powerful greenhouse gases. However, this review investigates the use of metered dose inhalers which continue to be on the rise in Denmark despite evidence that most patients are treated equally well with dry powder inhalers. If the use of metered dose inhalers in Denmark were reduced to approximately the level seen in Sweden it would lead to a reduction in CO2e comparable with the emissions from the electricity used in 16,500 typical Danish households.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Air Pollution",
- "Particulate Matter",
- "Air Pollutants",
- "Meteorological Concepts",
+ "Asthma",
+ "Nebulizers and Vaporizers",
+ "Metered Dose Inhalers",
+ "Dry Powder Inhalers",
+ "Respiration Disorders",
"Respiratory Tract Diseases",
- "Iran",
- "Sulfur Dioxide",
- "Nitrogen Dioxide",
- "Random Forest"
- ]
+ "Administration, Inhalation"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39424373",
- "Title": "BMJ open quality",
- "ArticleTitle": "Implementation of a standardised questionnaire for documenting preoperative respiratory illness in paediatric patients.",
- "Abstract": "Paediatric patients often present with symptoms of respiratory illnesses in the weeks leading up to surgery. Current or recent illness can increase the risk of experiencing perioperative respiratory complications. Ideally, children with recent illnesses should be identified before coming to the hospital to determine the safest course of action. We recognised that our system lacked a standardised process for documenting preoperative respiratory illness during the preoperative phone call. The global aim of this quality improvement initiative was to decrease paediatric perioperative respiratory adverse events. The SMART Aim (Specific, Measurable, Achievable, Relevant and Time-bound) was to increase the percentage of patients with standardised documentation of preoperative respiratory illness from 0% to 90% by 1 March 2023. Implementation of a standardised preoperative illness questionnaire increased standardised illness documentation from 0% to 95%. Nurses quickly adopted this intervention and easily integrated it into their routine workflow. Clinical leaders elected to implement the intervention electronically across all three operating room (OR) locations (main OR, satellite location and procedure centre). Future implementation of additional standardised preoperative processes will be needed to improve the global aim of decreasing perioperative respiratory complications.",
+ "PMID": "37743291",
+ "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
+ "ArticleTitle": "[Research advances on allergen component-resolved diagnosis in respiratory allergic diseases].",
+ "Abstract": "Allergen component-resolved diagnosis (CRD) is an emerging molecular diagnostic technology, which can further clarify the protein profile of allergen components in allergic patients, achieve accurate detection of allergens, and have great significance and value for the precise prevention and treatment of allergic diseases. In this article, the CRD technology and its research progress in respiratory allergic diseases are introduced, and the importance of CRD in the evaluation, prevention and treatment of respiratory allergic diseases are discussed.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Surveys and Questionnaires",
- "Child",
- "Quality Improvement",
- "Documentation",
- "Preoperative Care",
- "Pediatrics",
- "Respiration Disorders",
- "Respiratory Tract Diseases",
- "Preoperative Period"
- ]
+ "Allergens",
+ "Hypersensitivity",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "9",
+ "Day": "25"
+ }
},
{
- "PMID": "39423508",
- "Title": "Ecotoxicology and environmental safety",
- "ArticleTitle": "Non-dietary exposure to phthalates in primary school children: Risk and correlation with anthropometric indices, cardiovascular and respiratory diseases.",
- "Abstract": "Phthalates are endocrine disruptors of increasing concern for human health; however, previous studies have only assessed the association between internal exposure and human health. We aimed to assess the non-carcinogenic and carcinogenic risks of non-dietary exposure to phthalates in indoor environments among primary school children and their correlations with health indicators. A study involving 54 children was conducted in Jinan, Shandong Province, China. Questionnaires and health examinations were conducted, dust in hard-to-clean corners of students' classrooms and homes was collected, and airborne phthalates in the middle of classrooms and family living rooms were sampled. The gas-phase phthalate concentrations, individual exposure, and non-carcinogenic and carcinogenic risks were calculated. Associations were estimated using linear mixed models. The findings revealed that phthalates posed a non-carcinogenic risk to 7.4\u202f% of the children and a moderate carcinogenic risk to 27.8\u202f% of the children, with higher non-carcinogenic and carcinogenic risks to girls than to boys. Five phthalates were negatively correlated with body mass index, dimethyl phthalate and diethyl phthalate (DEP) were significantly correlated with waist circumference, and di-iso-butyl phthalate (DiBP) was negatively correlated with hip circumference. DiBP, di-n-butyl phthalate, and DEP, were significantly correlated with cardiovascular disease, DEP and di (2-n-butoxyethyl) phthalate were correlated with decreased lung function, and di-n-octyl phthalate influenced airway inflammation. The findings indicated that phthalate exposure may negatively impact children's health, thereby warranting further comprehensive research on the health effects of these chemicals.",
+ "PMID": "37196630",
+ "Title": "Cell reports. Medicine",
+ "ArticleTitle": "Genetic insights into lung function inform better management of respiratory diseases.",
+ "Abstract": "Shrine et\u00a0al. conducted the largest multi-ancestry genome-wide meta-analysis of lung function and identified 1,020 signals associated with lung function. These provide novel insights into the genetic underpins of lung function and may inform better clinical management of respiratory disorders.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Phthalic Acids",
- "Male",
- "Female",
- "Child",
- "China",
- "Cardiovascular Diseases",
- "Air Pollution, Indoor",
- "Environmental Exposure",
+ "Genetic Predisposition to Disease",
+ "Genome-Wide Association Study",
"Respiratory Tract Diseases",
- "Anthropometry",
- "Dust",
- "Schools",
- "Endocrine Disruptors",
- "Risk Assessment",
- "Body Mass Index"
- ]
+ "Lung"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "5",
+ "Day": "18"
+ }
},
{
- "PMID": "39421822",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Daily diurnal temperature range associated with emergency ambulance calls: a nine-year time-series study.",
- "Abstract": "DTR might increase the risk of daily all-cause, cardiovascular-related, and respiratory-related EACs in Guangzhou, China. The associations were particularly strong among older adults, males, and during the warm season. Implementing public health policies is essential to mitigate the adverse health effects of DTR.",
+ "PMID": "36660842",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Pneumology: what's new in 2022].",
+ "Abstract": "This selection of pneumological novelties of the year 2022 is not limited to pharmacological acquisitions but also includes progress in diagnostic strategies and the global management of respiratory diseases. We have chosen three pneumological issues. As cannabis is the most consumed illegal substance in Switzerland, it is important to know its impact on pulmonary physiology. An update of the international guidelines on pulmonary fibrosis as well as the European guidelines on pulmonary hypertension provides practical answers to the many clinical problems encountered in the management of these diseases. The key messages from these two consensus documents are reported here.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Ambulances",
- "China",
- "Middle Aged",
- "Cardiovascular Diseases",
- "Temperature",
- "Aged",
- "Adult",
- "Emergency Medical Services",
+ "Pulmonary Medicine",
+ "Hypertension, Pulmonary",
"Respiratory Tract Diseases",
- "Seasons"
- ]
+ "Switzerland",
+ "Pulmonary Fibrosis"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "1",
+ "Day": "21"
+ }
},
{
- "PMID": "39419650",
- "Title": "Allergology international : official journal of the Japanese Society of Allergology",
- "ArticleTitle": "Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody.",
- "Abstract": "Characteristic symptoms of NSAID-exacerbated respiratory disease (N-ERD) include asthma, chronic eosinophilic rhinosinusitis with nasal polyposis, cysteinyl LT (CysLT) overproduction and NSAIDs hypersensitivity. Some N-ERD patients present with episodic treatment-resistant extra-respiratory symptoms (CysLT-associated coronary artery vasospasm, gastroenteritis, or skin rash). Even when using standard treatments for respiratory and extra-respiratory symptoms, including systemic corticosteroids and aspirin desensitization, it is difficult to control the clinical symptoms and severe type 2 inflammation involved with mast cells, eosinophils, ILC2s, and platelet activation. Few treatment options are applicable in a clinical setting. Therefore, identifying effective treatments is essential for managing N-ERD patients who suffer from these conditions. Our previous observational study demonstrated 12-month omalizumab treatment of N-ERD was clinically effective against respiratory symptoms. Despite the remaining eosinophilia, omalizumab significantly reduced urinary LTE",
+ "PMID": "36384699",
+ "Title": "The Journal of veterinary medical science",
+ "ArticleTitle": "A retrospective analysis for criteria of surgical intervention in Japanese Black calves with respiratory signs caused by perinatal rib fracture.",
+ "Abstract": "Medical records of 16 Japanese Black calves with respiratory signs associated with perinatal rib fracture were analyzed, retrospectively, to speculate criteria of surgical intervention for the disease. For this analysis, the severity of respiratory condition was classified into three grades: Grade 1, with no wheezing, Grade 2, with wheezing after excitement but not at rest and Grade 3, with wheezing at rest. Grade 1 (n=3) received only conservative management. Seven of Grade 2 (n=8) and all of Grade 3 (n=5) had surgical management. Clinical outcome was good in all of Grade 1, and the surgical success rate was 83% in other groups. Our result suggests that surgical intervention should be considered for cases with more the severity of Grade 2.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Omalizumab",
- "Anti-Inflammatory Agents, Non-Steroidal",
- "Antibodies, Anti-Idiotypic",
- "Asthma, Aspirin-Induced",
- "Anti-Allergic Agents",
- "Drug Hypersensitivity",
+ "Pregnancy",
+ "Female",
+ "Cattle",
+ "Animals",
+ "Rib Fractures",
+ "Retrospective Studies",
"Respiratory Tract Diseases",
- "Animals"
- ]
+ "Cattle Diseases"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39419227",
- "Title": "The Science of the total environment",
- "ArticleTitle": "Neighborhood plant community, airborne microbiota transferred indoors and prevalence of respiratory diseases are interrelated: A cross-sectional study.",
- "Abstract": "Airborne microbiota transferred indoors (AMTI) is linked to human respiratory health. Yet, the factors influencing these microorganisms and their connections to the prevalence of respiratory diseases (RDs) remain unclear. In this study, we examined plant communities and AMTI using VenTube, next-generation sequencing and quantitative polymerase chain reaction (qPCR) in 72 Shanghai neighborhoods in warm and cold seasons, respectively. To determine the prevalence of RDs, we collected 1026 questionnaires, enlisting 30\u00a0\u00b1\u00a05 volunteers aged 40-80, residing in the area for more than a decade, with an equal gender balance. Our results demonstrated that the AMTI communities were less diverse in the cold season than in the warm season, which is in agreement with the changes of garden plant diversity between seasons. Along the reduction of AMTI diversity, greater relative abundances of RDs-associated microbes (e.g., Pseudomonas and Streptococcus) was transferred indoors during the cold season. The questionnaire survey showed that the most prevalent symptom was shortness of breath (25.6\u00a0%), followed by rhinitis (20.8\u00a0%) and wheeze (14.4\u00a0%), with generally no prevalence difference between urban and peri-urban neighborhoods. Notably, despite the sparse garden plant community in the cold season, the abundance of Oleaceae trees showed an inverse relationship with the RDs-associated microbes as well as the prevalences of RDs based on the structural equation model results. This finding was largely supported by the negative effect of Oleaceae trees on the population of Streptococcus anginosus (qPCR) which was a dominant species transferred indoors in the cold season, given that S. anginosus is highly associated with rhinitis and rhinoconjunctivitis. Taken together, our findings suggest a strong association between the Oleaceae trees, the AMTI and the prevalence of RDs, which can shed some lights in the ecological development towards respiratory safe environment in cities.",
+ "PMID": "35970539",
+ "Title": "Thorax",
+ "ArticleTitle": "Tobacco industry ownership of pharmaceutical companies: an international survey of people with respiratory disease.",
+ "Abstract": "The 2021 purchase of the respiratory pharmaceutical company Vectura by Phillip Morris International has been criticised by the public health and medical community, as a conflict of interest, with little input to date, from the patient community or the public. To address this gap, the COPD Foundation, along with global partners, surveyed 1196 people with chronic respiratory disease. 70% were bothered by a tobacco company making an inhaler to treat lung conditions and 48% reported that they would want to switch inhalers if they knew that a tobacco company made or sold their inhaler devices. Patients care about who makes the therapies used to treat their diseases.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Microbiota",
- "Air Microbiology",
- "Middle Aged",
- "Cross-Sectional Studies",
- "China",
- "Prevalence",
- "Adult",
- "Female",
- "Aged",
- "Air Pollution, Indoor",
+ "Tobacco Industry",
+ "Ownership",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Nebulizers and Vaporizers",
+ "Respiration Disorders",
"Respiratory Tract Diseases",
- "Male",
- "Plants",
- "Aged, 80 and over"
- ]
+ "Pharmaceutical Preparations",
+ "Administration, Inhalation"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "8",
+ "Day": "16"
+ }
},
{
- "PMID": "39410863",
- "Title": "Current opinion in pulmonary medicine",
- "ArticleTitle": "Household air pollution and respiratory health in Africa: persistent risk and unchanged health burdens.",
- "Abstract": "Respiratory infections, particularly in children, and other chronic respiratory diseases, are strongly attributable to household air pollution. Elimination of such exposures through interventions such as cleaner fuels and preferably, electricity, is critical to improving respiratory health on the continent.",
+ "PMID": "35880527",
+ "Title": "Emergency medicine Australasia : EMA",
+ "ArticleTitle": "Respiratory presentations and admissions at Bathurst Base Hospital emergency department: Exploring the impacts of the recent bushfire crisis.",
+ "Abstract": "To examine respiratory-related ED admissions and presentations at Bathurst Base Hospital during the 2019-2020 New South Wales bushfire crisis.A retrospective clinical audit was undertaken. Publicly available data on air quality were also examined.Poorer air quality (measured by PM10 levels) was correlated with increased presentations to the ED (R\u00a0=\u20090.228, P\u00a0=\u20090.012). ED patients with respiratory diagnoses were more likely to be admitted for inpatient care in 2019-2020 (n\u00a0=\u2009234, 49.3%) compared with 2018-2019 (n\u00a0=\u2009165, 39.6%).The impact of bushfire smoke needs to be considered in the allocation of resources in this area in future, but further research is warranted to understand the full extent of impact at the local level.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Emergency Service, Hospital",
+ "Fires",
+ "Hospitals",
"Humans",
- "Africa",
- "Air Pollution, Indoor",
- "Environmental Exposure",
- "Respiratory Tract Infections",
"Respiratory Tract Diseases",
- "Female",
- "Risk Factors",
- "Family Characteristics",
- "Child",
- "Male"
- ]
+ "Retrospective Studies",
+ "Smoke"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "27"
+ }
},
{
- "PMID": "39408565",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "Update on the Role of \u03b22AR and TRPV1 in Respiratory Diseases.",
- "Abstract": "Respiratory diseases (RDs) constitute a common public health problem both in industrialized and developing countries. The comprehension of the pathophysiological mechanisms underlying these conditions and the development of new therapeutic strategies are critical for improving the quality of life of affected patients. \u03b22-adrenergic receptor (\u03b22AR) and transient receptor potential vanilloid 1 (TRPV1) are both involved in physiological responses in the airways. \u03b22AR is implicated in bronchodilation, mucociliary clearance, and anti-inflammatory effects, while TRPV1 is involved in the mediation of pain and cough reflexes. In RDs, such as respiratory infections, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, the concentration and expression of these receptors can be altered, leading to significant consequences. In this review, we provided an update on the literature about the role of \u03b22AR and TRPV1 in these conditions. We reported how the diminished or defective expression of \u03b22AR during viral infections or prolonged therapy with \u03b22-agonists can increase the severity of these pathologies and impact the prognosis. Conversely, the role of TRPV1 was pivotal in neuroinflammation, and its modulation could lead to innovative treatment strategies in specific patients. We indicate future perspectives and potential personalized treatments in RDs through a comprehensive analysis of the roles of these receptors in the physiological and pathological mechanisms of these pathologies.",
+ "PMID": "35724916",
+ "Title": "Drug discovery today",
+ "ArticleTitle": "Recent advances in lung-on-a-chip models.",
+ "Abstract": "With the global burden of respiratory diseases, rapid identification of the best therapeutic measures to combat these diseases is essential. Animal models and 2D cell culture models do not replicate the findings observed in vivo. To gain deeper insight into lung pathology and physiology, 3D and advanced lung-on-a-chip models have been developed recently. Lung-on-a-chip models more accurately simulate the lung's microenvironment and functions in vivo, resulting in more-accurate assessments of drug safety and effectiveness. This review discusses the transition from 2D to 3D models and the recent advances in lung-on-a-chip platforms, their implementation and the numerous challenges faced. Finally, a general overview of this platform and its potential applications in respiratory disease research and drug discovery is highlighted.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "TRPV Cation Channels",
- "Receptors, Adrenergic, beta-2",
"Animals",
+ "Cell Culture Techniques",
+ "Drug Discovery",
+ "Lab-On-A-Chip Devices",
+ "Lung",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "6",
+ "Day": "21"
+ }
},
{
- "PMID": "39406209",
- "Title": "The American journal of tropical medicine and hygiene",
- "ArticleTitle": "Case Report: Effects of Environmental Smoke Exposure on Respiratory Conditions-A Report of an Aboriginal Man Fire Hunting for Mud Turtles in the Top End, Northern Territory of Australia.",
- "Abstract": "Environmental smoke has been shown to have significant associations with both causation and exacerbation of respiratory conditions. Aboriginal Australians in the Northern Territory (NT) of Australia are disproportionately affected by respiratory illness in comparison with non-Aboriginal Australians. Traditionally, Aboriginal communities have utilized fire for multiple purposes, such as land management practices, cultural ceremonies, hunting, and cooking. In this report, we describe an Aboriginal man who presented with acute exacerbation of airway disease after environmental smoke exposure while being in the close vicinity of \"fire hunting\" for \"mud turtles\" from a Top End remote Aboriginal community in the NT of Australia. This report highlights the potential impact of nontobacco environmental smoke exposure contributing to the causation and exacerbation of chronic respiratory conditions among Aboriginal Australians. Hence, further research is warranted to address mitigating strategies in this population.",
+ "PMID": "35699380",
+ "Title": "DNA and cell biology",
+ "ArticleTitle": "Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review.",
+ "Abstract": "MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression through recognition of cognate sequences and interference of transcriptional, translational, or epigenetic processes. Hundreds of miRNA genes have been found in diverse viruses, and many of these are phylogenetically conserved. Respiratory viruses are the most frequent causative agents of disease in humans, with a significant impact on morbidity and mortality worldwide. Recently, the role of miRNAs in respiratory viral gene regulation, as well as host gene regulation during disease progression, has become a field of interest. This review highlighted the importance of various miRNAs and their potential role in fighting with respiratory viruses as therapeutic molecules with a focus on COVID-19.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Biomarkers",
+ "COVID-19",
+ "Gene Expression Regulation, Viral",
"Humans",
- "Male",
- "Northern Territory",
- "Animals",
- "Smoke",
- "Turtles",
- "Environmental Exposure",
- "Adult",
- "Respiratory Tract Diseases"
- ]
+ "MicroRNAs",
+ "Respiratory Tract Diseases",
+ "Viruses"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "6",
+ "Day": "15"
+ }
},
{
- "PMID": "39395132",
- "Title": "Aging clinical and experimental research",
- "ArticleTitle": "Exploring the relationship between sarcopenia and 11 respiratory diseases: a comprehensive mendelian randomization analysis.",
- "Abstract": "This data-driven MR analysis revealed SP was bidirectional causally associated with lung diseases, providing genetic evidence for further mechanistic and clinical studies to understand the crosstalk between SP and lung diseases.",
+ "PMID": "35691630",
+ "Title": "The Veterinary clinics of North America. Food animal practice",
+ "ArticleTitle": "How Forces of a Complex Adaptive System Affect Ability to Control Bovine Respiratory Disease in Feeder Cattle.",
+ "Abstract": "This chapter provides an introductory look into the practical application of the principals of systems thinking as a methodology to gain deeper understanding of the nature of bovine respiratory disease (BRD) in current North American beef production models. The \"limits to success\" archetype is used to explore the dynamic relationship between technological BRD mitigation improvements and the resultant adaptive changes made by the system. The chapter concludes, by using the tragedy of the common archetype, with an investigation into how the common shared resource of antimicrobials can be damaged and depleted over time.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Mendelian Randomization Analysis",
- "Sarcopenia",
- "Genome-Wide Association Study",
- "Body Mass Index",
- "Respiratory Tract Diseases",
- "Male",
- "Pulmonary Disease, Chronic Obstructive",
- "Female",
- "Smoking",
- "Pneumoconiosis"
- ]
+ "Animals",
+ "Bovine Respiratory Disease Complex",
+ "Cattle",
+ "Respiratory System",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "6",
+ "Day": "13"
+ }
},
{
- "PMID": "39394579",
- "Title": "BMC public health",
- "ArticleTitle": "Association between use of heated tobacco products and long-term respiratory effects considering smoking history: internet-based cross-sectional study in Japan.",
- "Abstract": "These results suggest that smoking history before HTP using affects the occurrence of outcomes, and underscore the importance of considering smoking history when assessing the health effect of HTP use. Since the duration of HTP use is considerably shorter than that of cigarette use at present, further research, such as follow-up surveys assessing the long-term respiratory effects of HTP use, will be necessary.",
+ "PMID": "35691626",
+ "Title": "The Veterinary clinics of North America. Food animal practice",
+ "ArticleTitle": "High-Risk Cattle Management and Stocker Calf Health: Modulation of the Bovine Respiratory Microbiome from a Systems Perspective.",
+ "Abstract": "Bovine respiratory disease (BRD) affects animals in all segments of the North American beef industry. The segmented nature of the beef industry results in the marketing of cattle that are considered to be at high risk of developing BRD. The microbiota is the complex microbial ecosystem that exists in and on the body of all animals. The respiratory tract has its unique microbiota that is shaped by many factors. Stress reduction, appropriate nutritional management, strategic use of vaccines, and antimicrobial administration targeted to the highest risk individuals have the potential to stabilize an inherently unstable microbial population and enhance calf health.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Japan",
- "Cross-Sectional Studies",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Tobacco Products",
- "Surveys and Questionnaires",
- "Internet",
- "Smoking",
- "Hot Temperature",
- "Aged",
- "Young Adult",
+ "Animals",
+ "Anti-Bacterial Agents",
+ "Cattle",
+ "Cattle Diseases",
+ "Mannheimia haemolytica",
+ "Microbiota",
+ "Respiratory System",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "6",
+ "Day": "13"
+ }
},
{
- "PMID": "39391315",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "Liquid-liquid phase separation: a new perspective on respiratory diseases.",
- "Abstract": "Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.",
+ "PMID": "35219488",
+ "Title": "The Veterinary clinics of North America. Food animal practice",
+ "ArticleTitle": "Bovine Respiratory Disease Considerations in Young Dairy Calves.",
+ "Abstract": "Raising young dairy calves presents many challenges for producers and veterinarians including losses attributable to BRD. This article will discuss several key concepts for practitioners to consider when applying evidence-based medicine for the control and treatment of BRD in young dairy calves. The authors review BRD complex, provide considerations for diagnostic approaches, and discuss research associated with the control and treatment of BRD.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
"Animals",
- "Respiratory Tract Diseases",
- "Liquid-Liquid Extraction",
- "Signal Transduction",
- "Phase Separation"
- ]
+ "Bovine Respiratory Disease Complex",
+ "Cattle",
+ "Dairying",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "2",
+ "Day": "28"
+ }
},
{
- "PMID": "39389134",
- "Title": "The Science of the total environment",
- "ArticleTitle": "Risk assessment of PM",
- "Abstract": "Air pollution mainly comes from fossil energy consumption (FEC), and it brings great threat to public health. The respiratory system of the elderly is highly susceptible to the effects of air pollution due to the decline in body functions. PM",
+ "PMID": "34964566",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "Pediatric pulmonology 2020 year in review: Rare and diffuse lung disease.",
+ "Abstract": "Pediatric Pulmonology publishes original research, review articles, and case reports on topics related to a wide range of children's respiratory disorders. Here we review some of the most notable manuscripts published in 2020 in this journal on (1) children's interstitial lung disease (chILD), (2) congenital airway and lung anomalies, and (3) primary ciliary dyskinesia and other non-cystic fibrosis bronchiectasis. The articles reviewed are discussed in context with published works from other journals.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Particulate Matter",
- "Aged",
+ "Bronchiectasis",
+ "Child",
"Humans",
- "Air Pollutants",
- "Risk Assessment",
- "China",
- "Air Pollution",
- "Environmental Exposure",
- "Fossil Fuels",
- "Aged, 80 and over",
+ "Lung Diseases, Interstitial",
+ "Pulmonary Medicine",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
- "PMID": "39384295",
- "Title": "BMJ (Clinical research ed.)",
- "ArticleTitle": "Rainfall events and daily mortality across 645 global locations: two stage time series analysis.",
- "Abstract": "Daily rainfall intensity is associated with varying health effects, with extreme events linked to an increasing relative risk for all cause, cardiovascular, and respiratory mortality. The observed associations varied with local climate and urban infrastructure.",
+ "PMID": "34876198",
+ "Title": "Italian journal of pediatrics",
+ "ArticleTitle": "Developments in pediatrics in 2020: choices in allergy, autoinflammatory disorders, critical care, endocrinology, genetics, infectious diseases, microbiota, neonatology, neurology, nutrition, ortopedics, respiratory tract illnesses and rheumatology.",
+ "Abstract": "In this article, we describe the advances in the field of pediatrics that have been published in the Italian Journal of Pediatrics in 2020. We report progresses in understanding allergy, autoinflammatory disorders, critical care, endocrinology, genetics, infectious diseases, microbiota, neonatology, neurology, nutrition, orthopedics, respiratory tract illnesses, rheumatology in childhood.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
+ "COVID-19",
+ "Child Nutrition Sciences",
+ "Critical Care",
+ "Endocrinology",
+ "Gastrointestinal Microbiome",
"Humans",
- "Rain",
- "Cardiovascular Diseases",
+ "Hypersensitivity",
+ "Infectious Disease Medicine",
+ "Neonatology",
+ "Neurology",
+ "Orthopedics",
+ "Pediatrics",
+ "Rare Diseases",
"Respiratory Tract Diseases",
- "Global Health",
- "Cause of Death",
- "Mortality",
- "Time Factors"
- ]
+ "Rheumatology"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39384238",
- "Title": "BMJ open",
- "ArticleTitle": "Objectively measured daily steps and health outcomes: an umbrella review of the systematic review and meta-analysis of observational studies.",
- "Abstract": "CRD42022347055.",
+ "PMID": "34861722",
+ "Title": "Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere",
+ "ArticleTitle": "[Pulmonary function testing in the cat - an overview].",
+ "Abstract": "This article provides an overview of currently available pulmonary function tests in cats, divided into invasive and non-invasive methods. Invasive techniques comprise arterial blood gas analysis and measurement of pulmonary mechanics. Non-invasive techniques include pulse oximetry and capnography, as well as methods not yet integrated into everyday practice such as tidal breathing airflow-volume loops, whole-body barometric plethysmography and thorax compression. In this article, the background, execution, interpretation, and limitations of each test are discussed. Proper performance and assessment of pulmonary function measurements may aid in understanding the pathophysiology of feline respiratory disease and in increasing objectivity when assessing the existing disease and treatment efficacy.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
- "MeshTerms": [
- "Humans",
- "Cardiovascular Diseases",
- "Observational Studies as Topic",
+ "MeshTerms": [
+ "Animals",
+ "Blood Gas Analysis",
+ "Cat Diseases",
+ "Cats",
+ "Respiratory Function Tests",
"Respiratory Tract Diseases",
- "Systematic Reviews as Topic",
- "Walking"
- ]
+ "Tidal Volume"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "12",
+ "Day": "4"
+ }
},
{
- "PMID": "39374569",
- "Title": "Biosensors & bioelectronics",
- "ArticleTitle": "Recent advances in biosensors detecting biomarkers from exhaled breath and saliva for respiratory disease diagnosis.",
- "Abstract": "The global demand for rapid and non-invasive diagnostic methods for respiratory diseases has significantly intensified due to the wide spread of respiratory infectious diseases. Recent advancements in respiratory disease diagnosis through the analysis of exhaled breath and saliva has attracted great attention all over the world. Among various analytical methods, biosensors can offer non-invasive, efficient, and cost-effective diagnostic capabilities, emerging as promising tools in this area. This review intends to provide a comprehensive overview of various biosensors for the detection of respiratory disease related biomarkers in exhaled breath and saliva. Firstly, the characteristics of exhaled breath and saliva, including their generation, composition, and relevant biomarkers are introduced. Subsequently, the design and application of various biosensors for detecting these biomarkers are presented, along with the innovative materials employed as sensitive components. Different types of biosensors are reviewed, including electrochemical, optical, piezoelectric, semiconductor, and other novel biosensors. At last, the challenges, limitations, and future trends of these biosensors are discussed. It is anticipated that biosensors will play a significant role in respiratory disease diagnosis in the future.",
+ "PMID": "34836558",
+ "Title": "Radiologic clinics of North America",
+ "ArticleTitle": "Pediatric Neck Masses: Imaging Guidelines and Recommendations.",
+ "Abstract": "Neck masses commonly present in children and several potential diagnostic and management pathways exist, though with a paucity of evidence-based recommendations. The purpose of this article is to evaluate the current literature and utilization of various diagnostic imaging modalities , with a review of imaging features and management pearls for pediatric neck masses. A comprehensive understanding and practical imaging workflow will guide optimal patient workup and management.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Adolescent",
+ "Child",
+ "Child, Preschool",
+ "Diagnosis, Differential",
+ "Diagnostic Imaging",
+ "Female",
+ "Head and Neck Neoplasms",
"Humans",
- "Biosensing Techniques",
- "Biomarkers",
- "Saliva",
- "Breath Tests",
+ "Infant",
+ "Infant, Newborn",
+ "Lymphatic Diseases",
+ "Male",
+ "Mouth Diseases",
+ "Neck",
+ "Practice Guidelines as Topic",
"Respiratory Tract Diseases",
- "Exhalation",
- "Electrochemical Techniques",
- "Equipment Design"
- ]
+ "Thyroid Diseases"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "11",
+ "Day": "28"
+ }
},
{
- "PMID": "39370174",
- "Title": "The Indian journal of tuberculosis",
- "ArticleTitle": "Psychological comorbidities: Impact on respiratory health.",
- "Abstract": "Respiratory diseases are commonly associated with mental health issues, which add to morbidity and mortality. However, this association has never received sufficient attention. There is an urgent need to sensitize the health care workers for early identification of psychological comorbidities, and their basic management. Mental health should be an integral part of the teaching curriculum. Simple, quick and easy to use screening questionnaires should be used on a routine basis for identifying stigma, psychological distress and poor health related quality of life. Psychiatrist should be a vital part of the multidisciplinary teams. Extensive collaborative research needs to be carried out in this field to devise clear-cut recommendations for day-to-day practise.",
+ "PMID": "34600632",
+ "Title": "Emergency medicine clinics of North America",
+ "ArticleTitle": "Abdominal Pain in the Emergency Department: Missed Diagnoses.",
+ "Abstract": "Abdominal pain is the most common chief complaint in the Emergency Department. Abdominal pain is caused by a variety of gastrointestinal and nongastrointestinal disorders. Some frequently missed conditions include biliary pathology, appendicitis, diverticulitis, and urogenital pathology. The Emergency Medicine clinician must consider all aspects of the patient's presentation including history, physical examination, laboratory testing, and imaging. If no diagnosis is identified, close reassessment of pain, vital signs, and physical examination are necessary to ensure safe discharge. Strict verbal and written return precautions should be provided to the patient.",
"Predictions": [
- "Chronic respiratory disease",
- "Mental Health"
+ "Cancer",
+ "Chronic respiratory disease"
],
"MeshTerms": [
+ "Abdominal Pain",
+ "Aortic Aneurysm, Abdominal",
+ "Appendicitis",
+ "Cholecystitis",
+ "Diabetic Ketoacidosis",
+ "Emergency Service, Hospital",
+ "Female",
"Humans",
- "Comorbidity",
- "Mental Disorders",
+ "Male",
+ "Mesenteric Ischemia",
+ "Missed Diagnosis",
+ "Neoplasms",
+ "Nephrolithiasis",
+ "Ovarian Torsion",
+ "Patient Discharge",
"Respiratory Tract Diseases",
- "Quality of Life",
- "Mental Health"
- ]
+ "Sexually Transmitted Diseases",
+ "Spermatic Cord Torsion",
+ "Urinary Tract Infections"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39370173",
- "Title": "The Indian journal of tuberculosis",
- "ArticleTitle": "Psychological disorders in tuberculosis and respiratory diseases.",
- "Abstract": "",
+ "PMID": "34379366",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "2020 year in review: Neonatal pulmonology.",
+ "Abstract": "Pediatric Pulmonology publishes original research, reviews, and case reports related to a wide range of children's respiratory disorders. This review summarizes the past year's publications in the topic area of neonatal pulmonology, in the context of selected literature from other journals relevant to the discipline.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Child",
"Humans",
- "Mental Disorders",
- "Tuberculosis, Pulmonary",
- "Tuberculosis",
+ "Infant, Newborn",
+ "Pulmonary Medicine",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "8",
+ "Day": "12"
+ }
},
{
- "PMID": "39366894",
- "Title": "Revue des maladies respiratoires",
- "ArticleTitle": "[The impact of maternal smoking during pregnancy on respiratory disease in children].",
- "Abstract": "Among the causes of abnormal fetal lung development, active and environmental maternal smoking represents a major potential target in preventive medicine. Prevalence of smoking among women, particularly during pregnancy, varies across the different regions of the world. We reviewed the literature on the repercussions of maternal smoking on the lungs of the fetus and the neonate. One of the main consequences is prematurity, leading to pulmonary bronchodysplasia followed by respiratory infections, which particularly affect young children. In the medium- and long-term, smoking in utero leads to asthma and allergies, and is suspected to be associated with impaired respiratory function in children and teenagers. We also report on the potential effects of e-cigarettes, which represent an emerging threat to children's respiratory health.",
+ "PMID": "33892894",
+ "Title": "The veterinary clinics of North America. Exotic animal practice",
+ "ArticleTitle": "Respiratory Diseases in Guinea Pigs, Chinchillas and Degus.",
+ "Abstract": "The diagnosis and treatment of respiratory disease in pet guinea pigs, chinchillas, and degus still face profoundly serious challenges owing to their relatively small size, conspicuous clinical signs, difficulty for sampling, and insufficient scientific evidence to correlate signs and particular pathologies. This article is intended to summarize the available information on the relevant anatomy, physiology, and respiratory pathology in these species.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Pregnancy",
- "Female",
- "Prenatal Exposure Delayed Effects",
- "Smoking",
- "Child",
- "Infant, Newborn",
+ "Animals",
+ "Chinchilla",
+ "Guinea Pigs",
"Respiratory Tract Diseases",
- "Adolescent",
- "Maternal Exposure"
- ]
+ "Rodent Diseases",
+ "Rodentia"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "4",
+ "Day": "25"
+ }
},
{
- "PMID": "39364938",
- "Title": "The Veterinary record",
- "ArticleTitle": "Managing respiratory cases during supply issues.",
- "Abstract": "",
+ "PMID": "33892889",
+ "Title": "The veterinary clinics of North America. Exotic animal practice",
+ "ArticleTitle": "Diagnostic Imaging of the Respiratory Tract of the Reptile Patient.",
+ "Abstract": "Detailed information is given about technique and image interpretation of radiography and computed tomography of the respiratory tract in reptiles. MRI and sonography are mentioned when supporting differential diagnoses. Various diseases and imaging pitfalls are described with multiple figures and graphics. One focus is on lung compression in chelonians, which may be misinterpreted as pneumonia in dyspneic patients without the help of imaging tools.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Animals",
"Humans",
- "United Kingdom",
- "Veterinary Medicine",
+ "Reptiles",
+ "Respiratory System",
"Respiratory Tract Diseases"
- ]
- },
- {
- "PMID": "39362458",
- "Title": "Environmental research",
- "ArticleTitle": "Health effects of greenspace morphology: Large, irregular-shaped, well-connected, and close-clustered greenspaces may reduce mortality risks, especially for neighborhoods with higher aging levels.",
- "Abstract": "The healthcare burden has intensified with urbanization and aging populations in many global cities. While the health effects of urban greenspaces have been well documented, little is known about the associations between greenspace morphological features and health, especially in a high-density city with significant aging populations. Drawing on land use data with 10-m resolution, we assessed seven greenspace morphological metrics in terms of size (the percentage of greenspace, the largest pixel index, the average greenspace area), fragmentation (the patch density), shape (the average weighted shape index), connectedness (the cohesion index), and proximity (the aggregation index). We further conducted an ecological study to examine their associations with all-cause and three cause-specific (cardiovascular disease, respiratory disease, and cancer) mortality. Results from the negative binomial regression models revealed protective effects of five greenspace morphology metrics, including the percentage of greenspace, the largest pixel index, the average weighted shape index, the cohesion index, and the aggregation index, on mortality. The shape index showed the greatest effects, with every 1 Standard Deviation (SD) increase in the shape index linked to a reduction of 22.1% (95% CI: 22.0%-31.0%) in all-cause mortality, 22.1% (12.2%-30.8%) in mortality from cardiovascular diseases, 25.0% (14.0%-34.6%) in mortality from respiratory diseases, and 22.0% (12.3%-30.6%) in mortality from cancers. Moreover, stratified analyses revealed that the health effects of the cohesion index and the aggregation index were significantly more pronounced in neighborhoods with higher aging levels. Our findings highlight the significance of greenspace morphology features, beyond greenspace quantity, in improving residents' health, particularly for societies with high aging populations.",
- "Predictions": [
- "Cancer",
- "Chronic respiratory disease",
- "Cardiovascular diseases"
],
- "MeshTerms": [
- "Humans",
- "Residence Characteristics",
- "Aged",
- "Mortality",
- "Cities",
- "Middle Aged",
- "Aging",
- "Cardiovascular Diseases",
- "Male",
- "Female",
- "Neoplasms",
- "Respiratory Tract Diseases",
- "Adult",
- "Aged, 80 and over"
- ]
+ "Date": {
+ "Year": "2021",
+ "Month": "4",
+ "Day": "25"
+ }
},
{
- "PMID": "39362179",
- "Title": "Respiratory investigation",
- "ArticleTitle": "Feasibility of a problem-solving exercise program based on short physical performance battery for older patients with chronic respiratory diseases: A multicenter, pilot clinical trial.",
- "Abstract": "University Hospital Medical Information Network Center (UMIN-CTR) UMIN: approval number: UMIN000048761.",
+ "PMID": "33559960",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "Pediatric pulmonology 2019 year in review: rare and diffuse lung disease.",
+ "Abstract": "Pediatric Pulmonology publishes original research, review articles, and case reports on topics related to a wide range of children's respiratory disorders. Here we review manuscripts published in 2019 in this journal and others on (1) anatomic lung, airway, and vascular malformations, (2) children's interstitial lung disease, and (3) primary ciliary dyskinesia and non-cystic fibrosis bronchiectasis.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Bronchiectasis",
+ "Child",
+ "Ciliary Motility Disorders",
"Humans",
- "Feasibility Studies",
- "Pilot Projects",
- "Aged",
- "Male",
- "Chronic Disease",
- "Female",
- "Exercise Therapy",
- "Prospective Studies",
- "Problem Solving",
- "Physical Functional Performance",
- "Aged, 80 and over",
+ "Lung Diseases, Interstitial",
+ "Pulmonary Medicine",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "2",
+ "Day": "10"
+ }
},
{
- "PMID": "39353528",
- "Title": "Environmental research",
- "ArticleTitle": "Diurnal temperature range and cardiopulmonary health in Taiwan: Evaluating impacts, thresholds, and vulnerable groups.",
- "Abstract": "The health impacts of the diurnal temperature range (DTR), which may be affected by climate change, have received little attention. The objectives of this study were (1) to evaluate the association of DTR and cardiopulmonary outcomes, (2) to select the proper thresholds for a DTR warning system, and (3) to identify vulnerable groups. The weather and health records in Taiwan from 2000 to 2019, with a maximum DTR of 12.8\u00a0\u00b0C, were analyzed using generalized additive models. The health outcomes included cardiovascular (CVD) and respiratory disease (RD) categories and several sub-categories, such as ischemic heart disease, stroke, pneumonia, asthma, and chronic obstructive pulmonary disease. The results showed that the associations of DTR and cardiopulmonary outcomes were as significant as, and sometimes even stronger than, those of the daily maximum temperature and daily minimum apparent temperature in the warm and cold seasons, respectively. The significant association began at DTR of 6\u00a0\u00b0C, lower than previously reported. The identified DTR warning thresholds were 8.5 and 11\u00a0\u00b0C for the warm and cold seasons, respectively. DTR is statistically significantly associated with a 5-36% and a 9-20% increase in cardiopulmonary emergency and hospitalized cases in the warm season with a 1\u00a0\u00b0C increase above 8.5\u00a0\u00b0C, respectively. In the cold season, DTR is significantly associated with 7-41%, 4-30%, and 36-100% increases in cardiopulmonary emergency, hospitalized, and mortality with a 1\u00a0\u00b0C increase above 11\u00a0\u00b0C, respectively. People with hypertension, hyperglycemia, and hyperlipidemia had even higher risks. Vulnerable age and sex groups were identified if they had a lower DTR-health threshold than the general population, which can be integrated into a warning system. In conclusion, DTR may be increased on a local or city scale under climate change; a DTR warning system and vulnerable group identification may be warranted in most countries for health risk reduction.",
+ "PMID": "33555722",
+ "Title": "Holistic nursing practice",
+ "ArticleTitle": "Use of Complementary and Alternative Medicine in Pediatric Respiratory Diseases.",
+ "Abstract": "In this study, our purpose was to determine prevalence of complementary and alternative medicine (CAM) in pediatric respiratory diseases and methods of CAM use accordingly. Each of the CAM treatment has a special risk/benefit combination and it is absolutely crucial for health care professionals to question those methods.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Taiwan",
+ "Adolescent",
+ "Child",
+ "Child, Preschool",
+ "Complementary Therapies",
+ "Cross-Sectional Studies",
+ "Female",
"Humans",
- "Cardiovascular Diseases",
- "Climate Change",
- "Temperature",
- "Middle Aged",
- "Aged",
- "Adult",
- "Respiratory Tract Diseases",
+ "Infant",
"Male",
- "Female",
- "Seasons",
- "Vulnerable Populations",
- "Young Adult",
- "Adolescent"
- ]
+ "Pediatrics",
+ "Prevalence",
+ "Respiratory Tract Diseases",
+ "Surveys and Questionnaires"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "2",
+ "Day": "9"
+ }
},
{
- "PMID": "39354585",
- "Title": "Radiation oncology (London, England)",
- "ArticleTitle": "Respiratory adverse effects in patients treated with immune checkpoint inhibitors in combination with radiotherapy: a systematic review and meta-analysis.",
- "Abstract": "Our meta-analysis demonstrated that ICI combined with radiotherapy for solid tumors can produce respiratory adverse effects. ICIs combination treatment, a tumor located in the chest, is more likely to cause adverse reactions, and SBRT treatment and synchronous treatment will bring less incidence of adverse reactions. This study provide insights for clinicians to balance the risks of radiotherapy in the course of treating oncology patients.",
+ "PMID": "33256810",
+ "Title": "Italian journal of pediatrics",
+ "ArticleTitle": "Best practices, challenges and innovations in pediatrics in 2019.",
+ "Abstract": "This paper runs through key progresses in epidemiology, pathomechanisms and therapy of various diseases in children that were issued in the Italian Journal of Pediatrics at the end of last year. Novel research and documents that explore areas such as allergy, critical care, endocrinology, gastroenterology, infectious diseases, neonatology, neurology, nutrition, and respiratory tract illnesses in children have been reported. These observations will help to control childhood illnesses.",
"Predictions": [
- "Cancer",
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Ambulances",
+ "Enterovirus Infections",
+ "Growth Disorders",
+ "Hand Disinfection",
"Humans",
- "Immune Checkpoint Inhibitors",
- "Neoplasms",
- "Chemoradiotherapy",
- "Respiratory Tract Diseases"
- ]
+ "Hypersensitivity",
+ "Infant, Newborn",
+ "Infant, Newborn, Diseases",
+ "Jaundice, Obstructive",
+ "Malnutrition",
+ "Neonatology",
+ "Noninvasive Ventilation",
+ "Object Attachment",
+ "Osteomyelitis",
+ "Pain",
+ "Pediatrics",
+ "Respiratory Tract Diseases",
+ "Spinal Cord Compression",
+ "Tooth Injuries",
+ "Turner Syndrome",
+ "Vaccination",
+ "Virtual Reality"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
- "PMID": "39352090",
- "Title": "Central European journal of public health",
- "ArticleTitle": "Occupational respiratory disease in Eastern Slovakia between 1990-2021: a shift from agriculture to industrial manufacturing.",
- "Abstract": "This study found a decrease in the number of OA cases, as well as changes in economic sectors and causal agents associated with OA and OHP, specifically, in the agricultural sector, with MWFs from the industrial manufacturing sector now being the most common aetiological agent.",
+ "PMID": "33048388",
+ "Title": "Clinical anatomy (New York, N.Y.)",
+ "ArticleTitle": "The effects of obesity on the human body part II: Nervous, respiratory, and lymphatic systems.",
+ "Abstract": "This second installment of The Effects of Obesity on the Human Body considers the nervous, respiratory, and lymphatic systems. Those with obesity face countless psychological hurdles in addition to the respiratory burden and widespread inflammation that can suppress the immune system, resulting in the accumulation of excess fluid in body tissues.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
"Humans",
- "Slovakia",
- "Occupational Diseases",
- "Adult",
- "Male",
- "Female",
- "Prevalence",
- "Middle Aged",
- "Agriculture",
- "Occupational Exposure",
- "Manufacturing Industry",
- "Asthma, Occupational",
+ "Inflammation",
+ "Lymphatic Diseases",
+ "Nervous System Diseases",
+ "Obesity",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "10",
+ "Day": "14"
+ }
},
{
- "PMID": "39348213",
- "Title": "Journal of the Air & Waste Management Association (1995)",
- "ArticleTitle": "Combined health effects of air pollutant mixtures on respiratory mortality using BKMR in Hangzhou, China.",
- "Abstract": "Previous research on respiratory system mortality primarily focused on understanding their combined effects and have neglected the fact that air pollution mixtures are interrelated. This study used Bayesian kernel machine regression (BKMR) to analyze the relationship between air pollutant mixtures and respiratory mortality in Hangzhou, China from 2014 to 2018. The results showed a significant association between pollutant mixtures and respiratory system mortality primarily driven by PM",
+ "PMID": "32720775",
+ "Title": "Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace",
+ "ArticleTitle": "Pulmonary Rehabilitation.",
+ "Abstract": "Commenting on this book is a great privilege and an opportunity to share some emerging aspects regarding the development of pulmonary rehabilitation. Indeed, appreciating the therapeutic value of this modality is possible because of continuous research and tireless commitment of all professionals involved in the care of patients with respiratory diseases and pulmonary-related impairments....",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "China",
- "Air Pollutants",
+ "COVID-19",
"Humans",
- "Bayes Theorem",
- "Particulate Matter",
- "Air Pollution",
+ "Interdisciplinary Communication",
+ "Lung Transplantation",
+ "Practice Patterns, Physicians'",
+ "Rehabilitation",
+ "Respiratory Therapy",
"Respiratory Tract Diseases",
- "Sulfur Dioxide",
- "Environmental Exposure"
- ]
+ "SARS-CoV-2"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "7",
+ "Day": "29"
+ }
},
{
- "PMID": "39338131",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "Thermal Comfort Conditions and Mortality in Brazil.",
- "Abstract": "Conventional temperature-based approaches often overlook the intricate nature of thermal stress experienced by individuals. To address this limitation, climatologists have developed thermal indices-composite measures designed to reflect the complex interaction of meteorological factors influencing human perception of temperature. Our study focuses on Brazil, estimating the association between thermal comfort conditions and mortality related to respiratory and circulatory diseases. We examined four distinct thermal indices: the discomfort index (DI), net effective temperature (NET), humidex (H), and heat index (HI). Analyzing a comprehensive dataset of 2,872,084 deaths from 2003 to 2017, we found significant variation in relative risk (RR) based on health outcomes, exposure lag, percentile of exposure, sex/age groups, and specific thermal indices. For example, under high exposure conditions (99th percentile), we observed that the shorter lags (3, 5, 7, and 10) had the most robust effects on all-cause mortality. For example, under lag 3, the pooled national results for the overall population (all ages and sexes) indicate an increased risk of all-cause mortality, with an RR of 1.17 (95% CI: 1.13; 1.122) for DI, 1.15 (95% CI: 1.12; 1.17) for H, 1.15 (95% CI: 1.09; 1.21) for HI, and 1.18 (95% CI: 1.13; 1.22) for NET. At low exposure levels (1st percentile), all four distinct thermal indices were linked to an increase in all-cause mortality across most sex and age subgroups. Specifically, for lag 20, we observed an estimated RR of 1.19 (95% CI: 1.14; 1.23) for DI, 1.12 (95% CI: 1.08; 1.16) for H, 1.17 (95% CI: 1.12; 1.22) for HI, and 1.18 (95% CI: 1.14; 1.23) for NET. These findings have important implications for policymakers, guiding the development of measures to minimize climate change's impact on public health in Brazil.",
+ "PMID": "32588213",
+ "Title": "World journal of pediatrics : WJP",
+ "ArticleTitle": "Best practice for infection prevention in pediatric respiratory clinics during the COVID-19 epidemic.",
+ "Abstract": "During the COVID-19 epidemic, it is important for ensuring infection prevention and control in the pediatric respiratory clinics. Herein, we introduced the practice of infection prevention and control in pediatric respiratory clinics in China. Triage measures for patients who visit respiratory clinics, quality control for pediatric respiratory clinics and other preventive measures for related examinations and treatment have been introduced in this review article.",
"Predictions": [
- "Chronic respiratory disease",
- "Cardiovascular diseases"
+ "Chronic respiratory disease"
],
"MeshTerms": [
- "Brazil",
- "Humans",
- "Male",
- "Female",
- "Mortality",
- "Middle Aged",
- "Adult",
"Adolescent",
- "Aged",
+ "Ambulatory Care",
+ "Ambulatory Care Facilities",
+ "COVID-19",
"Child",
- "Young Adult",
- "Respiratory Tract Diseases",
- "Infant",
"Child, Preschool",
- "Cardiovascular Diseases",
- "Temperature",
- "Hot Temperature",
- "Aged, 80 and over",
- "Infant, Newborn"
- ]
+ "China",
+ "Communicable Disease Control",
+ "Coronavirus Infections",
+ "Female",
+ "Humans",
+ "Infection Control",
+ "Male",
+ "Pandemics",
+ "Pneumonia, Viral",
+ "Practice Guidelines as Topic",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "6",
+ "Day": "27"
+ }
},
{
- "PMID": "39334540",
- "Title": "The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease",
- "ArticleTitle": "Health status of Italian children living close to cultivations sprayed with pesticides.",
- "Abstract": "<sec><title>BACKGROUND</title>Pesticides are used to control pests, but they are toxic and may severely harm children's health. We assessed health outcomes in Italian children living close to cultivations sprayed with pesticides.</sec><sec><title>METHODS</title>In 2011-2012, 2,367 schoolchildren (6-14 years) living in eight Italian cities participated in the Indoor-School observational study. Parents filled in a standardised questionnaire on children's health and related risk factors. Children were classified as exposed to pesticides if living close to cultivations sprayed with pesticides. The association between the last three months of respiratory, allergic or systemic symptoms and pesticide exposure was assessed by multinomial logistic regression models, accounting for host/environmental risk factors.</sec><sec><title>RESULTS</title>Overall, 14% of children were exposed to pesticides, with significant differences among geographical areas: 21.2% in Northern Italy, 11.6% in Central Italy, and 9.7% in Southern Italy. Pesticide exposure was significantly associated with having: 1) 'often': eye symptoms (OR 3.81, 95% CI 2.06-7.05), skin symptoms (OR 2.60, 95% CI 1.34-5.03), lower airway symptoms (OR 2.38, 95% CI 1.41-4.01), systemic symptoms (OR 1.56, 95% CI 0.96-2.53, borderline); 2) 'daily': upper airways symptoms (OR 2.25, 95% CI 1.25-4.07) and systemic symptoms (OR 2.76, 95% CI 1.43-5.34).</sec><sec><title>CONCLUSIONS</title>Self-reported pesticide exposure was associated with respiratory, allergic or systemic symptoms in children. Public authorities should be aware of and intervene to mitigate this health risk.</sec>.",
+ "PMID": "32564785",
+ "Title": "Advances in clinical chemistry",
+ "ArticleTitle": "Aquaporins in health and disease.",
+ "Abstract": "Aquaporins (AQPs) are transmembrane channel proteins that mainly facilitate the water translocation through the plasma cell membrane. For several years these proteins have been extensively examined for their biologic role in health and their potential implication in different diseases. Technological improvements associated with the methods employed to evaluate the functions of the AQPs have provided us with significant new knowledge. In this chapter, we will examine the role of AQPs in health and disease based on the latest currently available evidence.",
"Predictions": [
+ "Cancer",
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Animals",
+ "Aquaporins",
"Humans",
- "Italy",
- "Child",
- "Pesticides",
- "Female",
- "Male",
- "Adolescent",
- "Environmental Exposure",
- "Surveys and Questionnaires",
- "Risk Factors",
- "Health Status",
- "Logistic Models",
- "Agriculture",
+ "Kidney Diseases",
+ "Neoplasms",
+ "Neurodegenerative Diseases",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "6",
+ "Day": "23"
+ }
},
{
- "PMID": "39332351",
- "Title": "International journal of hygiene and environmental health",
- "ArticleTitle": "Systematic review of impacts of occupational exposure to wildfire smoke on respiratory function, symptoms, measures and diseases.",
- "Abstract": "This review found a convincing body of evidence that occupational exposure to wildfires or prescribed burns has both acute and possibly longer-term respiratory effects among WFFs and some other emergency personnel. Given that these events are increasing, more needs to be done to identify those most at risk and mitigate these risks.",
+ "PMID": "32145836",
+ "Title": "The Veterinary clinics of North America. Equine practice",
+ "ArticleTitle": "Airway Diagnostics: Bronchoalveolar Lavage, Tracheal Wash, and Pleural Fluid.",
+ "Abstract": "Indications for bronchoalveolar lavage, tracheal wash, and thoracocentesis for the diagnosis of respiratory diseases are discussed. Each technique is described in detail and illustrated by videos. Sample handling, preparation and evaluation are reviewed. The advantages and limitations of bronchoalveolar lavage and tracheal wash procedures as well as a critical comparison between the 2 techniques for equine asthma diagnosis are presented. Finally, validated cut-off values for equine asthma diagnosis are reviewed.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
- "Humans",
- "Wildfires",
- "Smoke",
- "Occupational Exposure",
- "Firefighters",
+ "Animals",
+ "Asthma",
+ "Bronchoalveolar Lavage",
+ "Bronchoalveolar Lavage Fluid",
+ "Horse Diseases",
+ "Horses",
+ "Pleural Effusion",
"Respiratory Tract Diseases",
- "Respiratory Function Tests"
- ]
+ "Respiratory Tract Infections"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "3",
+ "Day": "9"
+ }
},
{
- "PMID": "39331188",
- "Title": "Neurosurgical review",
- "ArticleTitle": "Epidemiology and risk factors for adult gliomas died by respiratory diseases during the COVID-19 pandemic: a population-based study.",
- "Abstract": "RDs have become a crucial cause of death for gliomas. Those with advanced age and lower median household income have a higher risk of dying from respiratory diseases. Surgical treatment has been found to be safe for glioma patients and has been shown to reduce the risk of glioma patients dying from respiratory diseases. The study provides valuable insights for the perioperative management of gliomas patients in the post-pandemic era.",
+ "PMID": "31987717",
+ "Title": "Paediatric respiratory reviews",
+ "ArticleTitle": "Transition to adult care for young people with cerebral palsy.",
+ "Abstract": "Cerebral palsy (CP) is associated with a high burden of comorbid respiratory disease subsequent to multiple risk factors associated with increasing levels of disability. Correspondingly, respiratory disease is the leading cause of death in CP, including amongst young people who are transitioning or who have just transitioned between paediatric and adult healthcare services. Therefore, consideration of both preventive and therapeutic respiratory management is integral to transition in patients with CP, as summarised in this review.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Advance Care Planning",
+ "Cerebral Palsy",
+ "Epilepsy",
+ "Gastroesophageal Reflux",
"Humans",
- "COVID-19",
- "Glioma",
- "Male",
- "Middle Aged",
- "Female",
- "Risk Factors",
- "Adult",
- "Aged",
- "Brain Neoplasms",
- "SEER Program",
- "Young Adult",
- "Pandemics",
+ "Kyphosis",
+ "Noninvasive Ventilation",
+ "Pneumonia, Aspiration",
+ "Pulmonary Medicine",
"Respiratory Tract Diseases",
- "SARS-CoV-2"
- ]
+ "Scoliosis",
+ "Sleep Apnea, Obstructive",
+ "Transition to Adult Care",
+ "Transitional Care"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "1",
+ "Day": "29"
+ }
},
{
- "PMID": "39323116",
+ "PMID": "31402599",
"Title": "Pediatric pulmonology",
- "ArticleTitle": "The epidemiology of critical respiratory diseases in ex-premature infants in Vietnam: A prospective single-center study.",
- "Abstract": "EPIs with critical respiratory illnesses constituted a significant population in the PICU, required more PICU support, and had worse clinical outcomes compared to term infants.",
+ "ArticleTitle": "Pediatric Pulmonology Year in Review 2018: Rare lung disease, neuromuscular disease, and diagnostic testing.",
+ "Abstract": "Pediatric Pulmonology publishes original research, case reports, and review articles on topics related to a wide range of children's respiratory disorders. In this article, we highlight the past year's publications in the topic areas of rare lung diseases, respiratory complications of neuromuscular disorders, and diagnostic testing, as well as selected literature in these areas from other journals.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Bibliometrics",
+ "Child",
+ "Endoscopy",
"Humans",
- "Vietnam",
- "Male",
- "Female",
- "Prospective Studies",
"Infant",
- "Infant, Newborn",
- "Intensive Care Units, Pediatric",
- "Infant, Premature",
- "Critical Illness",
- "Respiration, Artificial",
- "Length of Stay",
- "Child, Preschool",
- "Respiratory Tract Diseases",
- "Infant, Premature, Diseases"
- ]
+ "Lung Diseases",
+ "Neuromuscular Diseases",
+ "Periodicals as Topic",
+ "Pulmonary Medicine",
+ "Rare Diseases",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "8",
+ "Day": "14"
+ }
},
{
- "PMID": "39316790",
- "Title": "JMIR public health and surveillance",
- "ArticleTitle": "The Effect of Long-Term Particulate Matter Exposure on Respiratory Mortality: Cohort Study in China.",
- "Abstract": "This cohort study provides causal clues of the respiratory impact of long-term ambient PM exposure, indicating that PM reduction efforts may continuously benefit the population's respiratory health.",
+ "PMID": "30952605",
+ "Title": "The American journal of emergency medicine",
+ "ArticleTitle": "Is my baby normal? A review of seemingly worrisome but normal newborn signs, symptoms and behaviors.",
+ "Abstract": "Infant patients are a unique challenge to emergency department (ED) physicians as the spectrum of normal infant signs, symptoms and behaviors are often difficult to differentiate from abnormal and potentially life-threatening conditions. In this article, we address some common chief complaints of neonates and young infants presenting to the ED, and contrast reassuring neonatal and young infant signs and symptoms against those that need further workup and intervention.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Emergency Service, Hospital",
+ "Eye Diseases",
+ "Gastrointestinal Diseases",
"Humans",
- "Particulate Matter",
- "China",
- "Male",
- "Female",
- "Middle Aged",
- "Cohort Studies",
- "Environmental Exposure",
- "Adult",
+ "Infant",
+ "Infant Behavior",
+ "Infant, Newborn",
+ "Infant, Newborn, Diseases",
"Respiratory Tract Diseases",
- "Aged",
- "Air Pollutants",
- "Air Pollution"
- ]
+ "Skin Diseases"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "4",
+ "Day": "7"
+ }
},
{
- "PMID": "39316681",
- "Title": "American journal of physiology. Lung cellular and molecular physiology",
- "ArticleTitle": "Mechanisms of mechanical stimulation in the development of respiratory system diseases.",
- "Abstract": "During respiration, mechanical stress can initiate biological responses that impact the respiratory system. Mechanical stress plays a crucial role in the development of the respiratory system. However, pathological mechanical stress can impact the onset and progression of respiratory diseases by influencing the extracellular matrix and cell transduction processes. In this article, we explore the mechanisms by which mechanical forces communicate with and influence cells. We outline the basic knowledge of respiratory mechanics, elucidating the important role of mechanical stimulation in influencing respiratory system development and differentiation from a microscopic perspective. We also explore the potential mechanisms of mechanical transduction in the pathogenesis and development of respiratory diseases such as asthma, lung injury, pulmonary fibrosis, and lung cancer. Finally, we look forward to new research directions in cellular mechanotransduction, aiming to provide fresh insights for future therapeutic research on respiratory diseases.",
+ "PMID": "30874818",
+ "Title": "Pediatric annals",
+ "ArticleTitle": "Persistent Wheeze in Infants: A Guide for General Pediatricians.",
+ "Abstract": "Infants with persistent wheeze is a common diagnostic challenge for the general pediatrician because of the broad differential diagnoses. The initial diagnostic approach should include a comprehensive history, physical examination, and chest radiography. Additional testing may be warranted. Involvement of a pediatric pulmonary subspecialist may also be indicated. [Pediatr Ann. 2019;48(3):e110-e114.].",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Child",
+ "Diagnosis, Differential",
"Humans",
- "Animals",
- "Respiratory Tract Diseases",
- "Mechanotransduction, Cellular",
- "Stress, Mechanical",
- "Extracellular Matrix",
- "Respiratory Mechanics"
- ]
+ "Infant",
+ "Pediatricians",
+ "Respiratory Sounds",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "3",
+ "Day": "16"
+ }
},
{
- "PMID": "39314792",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Causal effects of air pollutants on lung function and chronic respiratory diseases: a Mendelian randomization study.",
- "Abstract": "Our study ascertained the causal correlations of air pollutants with lung function and COPD, emphasizing the importance of reducing air pollution. Interleukin-17A mediates the reduction of FEV",
+ "PMID": "30809976",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "2018 year in review: Part 2 of 4: Neonatal lung disease.",
+ "Abstract": "Pediatric Pulmonology publishes original research, reviews and case reports related to a wide range of children's respiratory disorders. This review (Part 2 of a 4-part series) summarizes the past year's publications in the topic area of neonatal lung diseases, in the context of selected literature from other journals relevant to the discipline.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Biomarkers",
"Humans",
- "Mendelian Randomization Analysis",
- "Air Pollutants",
- "Particulate Matter",
- "Respiratory Function Tests",
- "Air Pollution",
- "Nitrogen Dioxide",
- "Environmental Exposure",
- "Chronic Disease",
- "Male",
- "Forced Expiratory Volume",
+ "Infant, Newborn",
+ "Infant, Premature",
+ "Infant, Premature, Diseases",
+ "Pulmonary Medicine",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "2",
+ "Day": "28"
+ }
},
{
- "PMID": "39304964",
- "Title": "Italian journal of pediatrics",
- "ArticleTitle": "Clinical application of flexible fiberoptic bronchoscopy in neonatal respiratory diseases.",
- "Abstract": "Flexible bronchoscopy could play an important role in diagnosing and identifying respiratory disorders in neonates and be safely used with few serious complications.",
+ "PMID": "30701948",
+ "Title": "Terapevticheskii arkhiv",
+ "ArticleTitle": "On respiratory manifestations of gastroesophageal reflux disease.",
+ "Abstract": "One of the manifestations of gastroesophageal reflux disease (GERD) is extraesophageal symptoms, in particular, from the upper and lower respiratory tract. Gastroesophageal reflux is capable of both causing respiratory symptoms independently and aggravating the course of already existing diseases of the respiratory system. The article presents available in the literature current information on the pathogenesis of GERD respiratory symptoms, their clinical course, considerations of diagnosis and treatment.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Diagnosis, Differential",
+ "Gastroesophageal Reflux",
+ "Glucocorticoids",
"Humans",
- "Bronchoscopy",
- "Infant, Newborn",
- "Retrospective Studies",
- "Male",
- "Female",
- "Fiber Optic Technology",
+ "Proton Pump Inhibitors",
"Respiratory Tract Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "2",
+ "Day": "1"
+ }
},
{
- "PMID": "39293035",
- "Title": "Pediatric allergy, immunology, and pulmonology",
- "ArticleTitle": "Pharmaceutical Therapies for Pediatric Respiratory Disease: Setbacks and Progress in 2024.",
- "Abstract": "",
+ "PMID": "30364219",
+ "Title": "F1000Research",
+ "ArticleTitle": "Recent advances in bronchoscopy.",
+ "Abstract": "Bronchoscopy is a very common tool for diagnosis and therapeutic purposes in dealing with diseases of the lungs and the airways. Thankfully, a multitude of new technologies have made it more accessible for the use of physicians. This article is a review of the indication of bronchoscopy as it is being used today for a variety of chest pathologies.",
"Predictions": [
"Chronic respiratory disease"
],
"MeshTerms": [
+ "Bronchoscopy",
"Humans",
- "Child",
- "Respiratory Tract Diseases",
- "Pediatrics"
- ]
+ "Lung Diseases",
+ "Pulmonary Medicine",
+ "Respiratory Tract Diseases"
+ ],
+ "Date": {
+ "Year": "2018",
+ "Month": "10",
+ "Day": "27"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/create_test_data.py b/testModel/dataset/create_test_data.py
index 8d9df36c7..718cd8611 100644
--- a/testModel/dataset/create_test_data.py
+++ b/testModel/dataset/create_test_data.py
@@ -2,37 +2,88 @@ import sys
import os
import json
import time
+from datetime import datetime
+from dateutil.relativedelta import relativedelta
# Ajouter le répertoire parent au chemin de recherche
-sys.path.append(os.path.abspath(os.path.join(os.path.dirname(__file__), "../")))
+sys.path.append(os.path.abspath(os.path.join(os.path.dirname(__file__), "../../")))
-from folders.dataSources.PubMed.pubmedApi import getPubmedData
+from dataSources.PubMed.pubmedApi import getPubmedData
+from dataSources.PubMed.util import get_mesh_noexp_term, url_encode
from variables.pubmed import NCDS, NCDS_MESH_TERM
+from variables.articles import LENGTH_CATEGORIES, LENGTH_CATEGORIES_TRESHOLDS
+from testModel.utils import get_article_data, get_dataset_filename
+
+DATASET_DIR = os.path.abspath(os.path.join(os.path.dirname(__file__), "./"))
date_min = "2024/01/01"
date_max = "2024/12/31"
-for id_term, mesh_term in enumerate(MESH_TERMS):
- data_list = getPubmedData(mesh_term, date_min, date_max, nb_items=10000)
+ncds_mesh_noexp = get_mesh_noexp_term(NCDS_MESH_TERM)
+
+stored_articles = []
+
+for id_ncd, ncd in enumerate(NCDS):
+
+ stored_length = {}
+ for length_category in LENGTH_CATEGORIES:
+ stored_length[length_category] = 0
+
+ search_term = url_encode(ncds_mesh_noexp[id_ncd])
data_store = []
- i = 0
-
- for data in data_list:
- for id_mesh, mesh in enumerate(MESH):
- if mesh in data["MeshTerms"]:
- data["Predictions"].append(LABELS[id_mesh])
-
- if len(data["Predictions"]) > 0:
- data_store.append(data)
- i+=1
-
- if len(data_store) >= 100:
- break
-
- filename = LABELS[id_term].replace(" ", "_").replace(",", "").lower()
-
- with open(f"./dataset/{filename}.json", "w") as json_file:
+
+ end_date = datetime(2024, 12, 31)
+
+ while (len(data_store) < 100):
+
+ start_date = end_date - relativedelta(years=1)
+
+ data_list = getPubmedData(search_term, start_date.strftime("%Y/%m/%d"), end_date.strftime("%Y/%m/%d"))
+
+ for data in data_list:
+ if data["PMID"] in stored_articles:
+ continue
+
+ article_mesh_terms = [mesh_term.lower() for mesh_term in data["MeshTerms"]]
+
+ for key, mesh_term in NCDS_MESH_TERM.items():
+ if mesh_term.lower() in article_mesh_terms:
+ data["Predictions"].append(key)
+
+ if len(data["Predictions"]) > 0:
+ title, abstract = get_article_data(data)
+
+ store = False
+ breaked = False
+ for id_treshold, treshold in enumerate(LENGTH_CATEGORIES_TRESHOLDS):
+ if len(title+abstract) < treshold:
+ if stored_length[LENGTH_CATEGORIES[id_treshold]] < 25:
+ store = True
+ stored_length[LENGTH_CATEGORIES[id_treshold]] += 1
+
+ breaked = True
+ break
+
+ if not store and not breaked:
+ if stored_length[LENGTH_CATEGORIES[-1]] < 25:
+ store = True
+ stored_length[LENGTH_CATEGORIES[-1]] += 1
+
+ if store:
+ data_store.append(data)
+ stored_articles.append(data["PMID"])
+
+ if len(data_store) == 100:
+ break
+
+ end_date = start_date
+
+ print(stored_length)
+
+ filename = get_dataset_filename(ncd)
+
+ with open(f"{DATASET_DIR}/{filename}.json", "w") as json_file:
json.dump(data_store, json_file, indent=4)
- time.sleep(1)
\ No newline at end of file
+ time.sleep(0.1)
\ No newline at end of file
diff --git a/testModel/dataset/diabetes.json b/testModel/dataset/diabetes.json
index b65ca4eaa..4ff9e8e81 100644
--- a/testModel/dataset/diabetes.json
+++ b/testModel/dataset/diabetes.json
@@ -3,7 +3,7 @@
"PMID": "39738300",
"Title": "Scientific reports",
"ArticleTitle": "Robust self management classification via sparse representation based discriminative model for mild cognitive impairment associated with diabetes mellitus.",
- "Abstract": "Diabetes Mellitus combined with Mild Cognitive Impairment (DM-MCI) is a high incidence disease among the elderly. Patients with DM-MCI have considerably higher risk of dementia, whose daily self-care and life management (i.e. self-management) have a significant impact on the development of their condition. Thus, the inclusion and discrimination of subsequent interventions according to their self-management is an urgent issue. A Sparse-representation-based Discriminative Classification model (SDC) is proposed in this paper to correctly classify MCI-DM patients based on their self-management ability. Specifically, an L",
+ "Abstract": "Diabetes Mellitus combined with Mild Cognitive Impairment (DM-MCI) is a high incidence disease among the elderly. Patients with DM-MCI have considerably higher risk of dementia, whose daily self-care and life management (i.e. self-management) have a significant impact on the development of their condition. Thus, the inclusion and discrimination of subsequent interventions according to their self-management is an urgent issue. A Sparse-representation-based Discriminative Classification model (SDC) is proposed in this paper to correctly classify MCI-DM patients based on their self-management ability. Specifically, an L-minimization sparse representation model, an efficient machine learning model, is used to obtain the sparse histogram that encodes the identity of the test sample. Then, the coefficient of determination [Formula: see text] is adopted to determine the category based on the sparse histogram of the test sample. Extensive experiments on the self-management data of DM-MCI are conducted to verify the effectiveness of SDC. The experimental results show that the accuracy [Formula: see text], precision [Formula: see text], recall [Formula: see text], and F1-score [Formula: see text] are 94.3%, 95.0%, 94.3%, and 94.5%, respectively, demonstrating the excellent performance of SDC. The model used in this study has high accuracy and can be used for subgroup discrimination. The use of the sparse representation model in this study has supportive implications for the inclusion of research subjects in clinical intervention strategies.",
"Predictions": [
"Diabetes"
],
@@ -16,7 +16,12 @@
"Male",
"Female",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737509",
@@ -41,7 +46,12 @@
"Cohort Studies",
"Age of Onset",
"Diabetes Mellitus, Type 2"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736942",
@@ -69,13 +79,18 @@
"Obesity",
"Infant",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736689",
"Title": "Lipids in health and disease",
"ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
- "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
+ "Abstract": "With metabolic disorders on the rise globally, the cardiometabolic index (CMI) has emerged as a crucial predictor of mortality risks linked to cancer, cardiovascular disease, and diabetes. This novel index, which combines lipid metabolism and body composition, is the focus of this study, aimed at exploring its association with all-cause and specific mortality in an all-age adult population.A longitudinal cohort study including 5,728 participants aged over 18 from nine cycles between 2001 and 2018 was enrolled and assessed. CMI served as the exposure variable, while outcomes included all-cause mortality and mortality due to cardiovascular disease, cancer, and diabetes. The Cox frailty model and average marginal effects were employed to evaluate the contribution of CMI to all-cause and specific mortality collectively. Restricted cubic spline analyses and stratified analyses were conducted to investigate potential nonlinear effects and interactions.The decreased participants exhibited considerably higher CMI than the alive's. A positive association was found between CMI and all-cause mortality (HR=1.05, 95% CI=1.01-1.10). Notably, CMI was linked to an increased risk of cancer mortality (HR=1.02) and a reduced risk of cardiovascular disease mortality (HR=0.85). Furthermore, the average marginal effect of CMI on diabetes mortality was the largest (AME=0.499). The RCS curves revealed that participants had the lowest risk of all-cause mortality at a CMI of 0.618. Sensitivity analyses further supported these findings.This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
"Predictions": [
"Diabetes",
"Cancer",
@@ -96,7 +111,12 @@
"Risk Factors",
"Cardiometabolic Risk Factors",
"Cohort Studies"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39735640",
@@ -118,7 +138,12 @@
"Insulin Resistance",
"Nephrocalcinosis",
"Tooth Abnormalities"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735551",
@@ -136,13 +161,18 @@
"Diabetes Mellitus",
"GPI-Linked Proteins",
"Drug Development"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735480",
"Title": "Turkish journal of medical sciences",
"ArticleTitle": "Burden of comorbidities in heart failure patients in T\u00fcrkiye.",
- "Abstract": "The most common comorbidities in cases of HF in T\u00fcrkiye are HT, ASCVD, dyslipidemia, DM, COPD, anemia, and AF, respectively, and more than 90% of patients have \u22652 comorbidities. While ASCVD and dyslipidemia were more common in male patients, anemia, DM, and anxiety disorders were more common in female patients. The number of comorbid conditions increased with advanced age.",
+ "Abstract": "Heart failure (HF) is associated with a wide range of comorbidities that negatively impact clinical outcomes and cause high economic burden. We aimed to evaluate the frequency and burden of comorbidities in HF patients in T\u00fcrkiye and their relationships with patients' demographic characteristics.Based on ICD-10 codes in the national electronic database of the Turkish Ministry of Health covering the entire population of T\u00fcrkiye (n = 85,279,553) from 1 January 2016 to 31 December 2022, data on the prevalence of comorbidities in HF patients were obtained. The frequency and burden of comorbidities were analyzed separately by age groups, sex, and socioeconomic status (SES).Between 2016 and 2022, there were 2,722,151 patients (51.7% female) of all ages who were diagnosed with HF. In T\u00fcrkiye, the most common comorbidities of HF patients were hypertension (HT) (97.6%), atherosclerotic cardiovascular disease (ASCVD) (84.9%), dyslipidemia (59.5%), anxiety disorder (48.1%), diabetes mellitus (DM) (45.2%), chronic obstructive pulmonary disease (COPD) (43.6%), anemia (40.6%), and atrial fibrillation (AF) (37.1%). Female patients had higher rates of anemia, DM, HT, and anxiety disorders, while male patients had higher rates of ASCVD, COPD, and dyslipidemia. The most common comorbidity in patients under 20 years of age was congenital heart disease (52.3%). More than 90% of HF patients had \u22652 comorbidities. HF patients with \u22655 comorbidities increased from 18.1% in the group aged 20-49 years to 38.3% in the group aged 50-79 years. Comorbidities were similar across SES groups.The most common comorbidities in cases of HF in T\u00fcrkiye are HT, ASCVD, dyslipidemia, DM, COPD, anemia, and AF, respectively, and more than 90% of patients have \u22652 comorbidities. While ASCVD and dyslipidemia were more common in male patients, anemia, DM, and anxiety disorders were more common in female patients. The number of comorbid conditions increased with advanced age.",
"Predictions": [
"Diabetes"
],
@@ -165,7 +195,12 @@
"Pulmonary Disease, Chronic Obstructive",
"Anemia",
"Dyslipidemias"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39734205",
@@ -187,7 +222,12 @@
"Hypoglycemic Agents",
"Drug Carriers",
"Drug Delivery Systems"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39733376",
@@ -212,7 +252,12 @@
"Aged",
"Clinical Laboratory Techniques",
"Diabetes Mellitus, Type 2"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732905",
@@ -236,7 +281,12 @@
"Prognosis",
"Risk Factors",
"Predictive Value of Tests"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732874",
@@ -258,7 +308,12 @@
"Acid-Base Equilibrium",
"ROC Curve",
"Prognosis"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732729",
@@ -280,13 +335,18 @@
"Inflammation Mediators",
"Obesity",
"Signal Transduction"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732433",
"Title": "Microvascular research",
"ArticleTitle": "Prevalence of microvascular complications and associated factors among diabetes mellitus patients in Ethiopia: Systematic review and meta-analysis.",
- "Abstract": "The review protocol was developed and was registered with PROSPERO registration number (CRD42023486459).",
+ "Abstract": "Diabetes mellitus (DM) is a metabolic abnormality affecting 537 million people worldwide. Poor glycemic control, longer duration, and poor medication adherence increased the risk of DM complications. Comprehensive evidence on the pooled prevalence of microvascular complications in DM patients in Ethiopia is not available. Furthermore, individual study findings for the prevalence of microvascular complications in DM patients, and associated factors were not consistent.This systemic review and meta-analysis aimed to assess the pooled prevalence of microvascular complications in DM patients, and its associated risk factors in Ethiopia.Systematic search on Scopus, PubMed, Science Direct electronic database, Google Scholar search engine, and library registration was used to identify relevant studies following reviews and meta-analysis guidelines. Microsoft Excel spreadsheets were used to extract data, and Extracted data was analyzed using STATA software version 17.0. A Sensitivity analysis was conducted to assess the role of each study in the final result and the presence of publication bias was assessed by Egger's test. Heterogeneity across studies was checked by Cochran's Q statistic and I2 statistics and significant heterogeneity was assessed using subgroup analysis.The pooled prevalence of microvascular complications in DM patients was 32.89\u00a0% (95\u00a0% CI: 28.17-37.60). In addition, the pooled prevalence of retinopathy, neuropathy, and nephropathy in DM patients was 17.16\u00a0% (95\u00a0% CI: 12-22\u00a0%), 10.49\u00a0% (95\u00a0% CI: 8-13\u00a0%) and 11.52\u00a0% (95\u00a0% CI: 9-15\u00a0%) respectively. Age >60\u00a0years old (AOR\u00a0=\u00a01.08 (95%CI\u00a0=\u00a01.02-1.15), longer duration of DM (AOR\u00a0=\u00a01.57 (95\u00a0% CI\u00a0=\u00a01.31-1.84), poor glycemic control (AOR\u00a0=\u00a02.21 (95\u00a0% CI\u00a0=\u00a01.52-2.91), poor adherence to diabetic medications (AOR\u00a0=\u00a03.61 (95\u00a0% CI\u00a0=\u00a01.83-5.38) and presence of hypertension (AOR\u00a0=\u00a02.26 (95\u00a0% CI\u00a0=\u00a01.73-2.80) ware associated risk factors for microvascular complications in DM patients.Around one-third of DM patients had one or more microvascular complications. Patients with advanced age, longer duration of DM, poor glycemic control, poor medication adherence, and comorbidity like hypertension should be targeted to tackle the occurrence and severity of microvascular complications in DM patients.The review protocol was developed and was registered with PROSPERO registration number (CRD42023486459).",
"Predictions": [
"Diabetes"
],
@@ -308,7 +368,12 @@
"Diabetes Mellitus",
"Young Adult",
"Adolescent"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39730723",
@@ -335,7 +400,12 @@
"United States",
"Incidence",
"Logistic Models"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39730510",
@@ -360,7 +430,44 @@
"Risk Factors",
"Adipose Tissue",
"United States"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "39729794",
+ "Title": "American journal of otolaryngology",
+ "ArticleTitle": "Sudden sensorineural hearing loss in diabetes mellitus patients receiving intra-tympanic steroid injections.",
+ "Abstract": "Sudden sensorineural hearing loss is an acute hearing disorder typically managed using steroids. However, prognostic factors of diabetes mellitus (DM) patients undergoing intra-tympanic steroid injections (ITSIs) are unclear. We explored the prognostic factors for ITSI in DM patients with unilateral SSNHL.This retrospective study enrolled 89 DM patients with unilateral SSNHL from July 2016 to June 2022. All patients received ITSIs, and their clinical and audiological data were analyzed.The patients' mean age was 49.31\u00a0\u00b1\u00a016.26\u00a0years. After ITSI, the mean hearing level gain was 14.91\u00a0\u00b1\u00a020.28\u00a0dB, the mean speech reception threshold (SRT) gain was 15.78\u00a0\u00b1\u00a032.16\u00a0dB, and the mean speech discrimination score (SDS) gain was 16.94\u00a0\u00b1\u00a035.06\u00a0%. Based on Siegel's criteria, 8 patients (8.98\u00a0%) had complete recovery, 14 (15.73\u00a0%) had partial recovery, 16 (17.98\u00a0%) had slight recovery, and 51 (57.31\u00a0%) had no improvement. Older age (odds ratio [OR]\u00a0=\u00a00.970, 95\u00a0% confidence interval [CI]: 0.941-0.999, p\u00a0=\u00a00.043) and profound hearing loss on pure-tone audiometry (PTA; OR\u00a0=\u00a00.058, 95\u00a0% CI: 0.007-0.462, p\u00a0<\u00a00.001) were adverse prognostic factors in univariate analyses. Older age (OR\u00a0=\u00a00.963, 95\u00a0% CI: 0.932-0.994, p\u00a0=\u00a00.023) and profound hearing loss (OR\u00a0=\u00a00.048, 95\u00a0% CI: 0.005-0.395, p\u00a0=\u00a00.004) were independent negative prognostic factors in a multivariate analysis.ITSI is effective and avoids side effects of high-dose steroids in patients with SSNHL and DM. Among 89 DM SSNHL patients who underwent ITSI, older age and profound hearing loss were negative prognostic factors. Prompt and active management is necessary for DM patients with these risk factors.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Hearing Loss, Sensorineural",
+ "Retrospective Studies",
+ "Hearing Loss, Sudden",
+ "Adult",
+ "Injection, Intratympanic",
+ "Prognosis",
+ "Aged",
+ "Age Factors",
+ "Treatment Outcome",
+ "Steroids",
+ "Diabetes Mellitus",
+ "Audiometry, Pure-Tone"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39729755",
@@ -380,13 +487,18 @@
"Spectrum Analysis, Raman",
"Spectroscopy, Near-Infrared",
"Equipment Design"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39725874",
"Title": "BMC cardiovascular disorders",
"ArticleTitle": "U-shaped association of uric acid to HDL cholesterol ratio (UHR) with ALL-cause and cardiovascular mortality in diabetic patients: NHANES 1999-2018.",
- "Abstract": "This study found a U-shaped relationship between UHR and both ALL-cause and cardiovascular mortality in diabetic population. This suggests that clinicians should control UHR around 9-10 to improve the long-term prognosis of diabetic patients.",
+ "Abstract": "To investigate the relationship between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and ALL-cause and cardiovascular mortality among diabetic patients.This study utilized health data from diabetic patients included in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The Kaplan-Meier curves was employed to preliminarily explore the association between UHR, its components, and all-cause and cardiovascular mortality in diabetic patients, as well as to analyze UHR levels and mortality across different genders. Subsequently, the Cox proportional hazards model was used to further investigate the relationship between UHR, its components, and mortality in diabetic patients. Restricted cubic spline (RCS) curves were applied to examine the nonlinear relationship between UHR, its components, and mortality, with a particular focus on the association between UHR and mortality across different genders.This longitudinal cohort study included a total of 6,370 participants, comprising 3,268 males and 3,102 females. Kaplan-Meier analysis revealed a positive correlation between UHR, UA, and mortality in diabetic patients, while the association between HDL and mortality was negligible. The Cox proportional hazards model demonstrated a positive association between UHR and mortality in the diabetic population, while the statistical effects of UA and HDL on mortality were less pronounced compared to UHR. When analyzed by gender, no significant linear relationship was observed between UHR and mortality in either males or females. Subsequently, RCS analysis indicated a U-shaped nonlinear relationship between UHR and mortality in the overall diabetic population and among female patients, with a similar trend observed in males. Furthermore, stratified RCS analysis confirmed the persistence of the U-shaped relationship between UHR and prognosis across most subgroups.This study found a U-shaped relationship between UHR and both ALL-cause and cardiovascular mortality in diabetic population. This suggests that clinicians should control UHR around 9-10 to improve the long-term prognosis of diabetic patients.",
"Predictions": [
"Diabetes",
"Cardiovascular diseases"
@@ -412,13 +524,18 @@
"Aged",
"Sex Factors",
"Risk Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39725454",
"Title": "BMJ paediatrics open",
"ArticleTitle": "\"Effect of post-kidney transplant diabetes mellitus on long-term outcomes in a cohort of pediatric kidney transplant recipients from 2005 to 2022.\" Survival analysis.",
- "Abstract": "Seventy-six paediatric kidney transplant recipients were included. The incidence of PTDM and iCHO was 6.6% and 9.2%, respectively. Patients with PTDM/iCHO had a significantly higher cumulative graft loss incidence than those without (34.4% vs 13.9% at 36 months, p<0.008). Multivariable analysis revealed a threefold increased risk of graft loss in patients with PTDM/iCHO (HR",
+ "Abstract": "Post-transplantation diabetes mellitus and carbohydrate intolerance (PTDM/iCHO) are complications following solid organ transplantation, which significantly increases the risk of graft loss and mortality. However, data concerning long-term outcomes in paediatric kidney transplant recipients with PTDM/iCHO are scarce. This study aimed to evaluate the risk of graft loss in paediatric kidney transplant recipients with PTDM or iCHO compared with non-PTDM/iCHO.The study cohort included patients aged <18\u2009who underwent a kidney transplant in a transplant centre from 2005 to 2022. The primary outcome was graft survival loss; secondary outcomes were acute rejection, renal function and mortality. Cumulative incidence of graft loss and acute rejection was estimated, considering death a competing risk. Fine and Gray's proportional subdistribution hazard model was used to analyse the effect of PTDM/iCHO status on the event.Seventy-six paediatric kidney transplant recipients were included. The incidence of PTDM and iCHO was 6.6% and 9.2%, respectively. Patients with PTDM/iCHO had a significantly higher cumulative graft loss incidence than those without (34.4% vs 13.9% at 36 months, p<0.008). Multivariable analysis revealed a threefold increased risk of graft loss in patients with PTDM/iCHO (HR 3.33, 95%\u2009CI 1.19 to 9.30, p=0.022). PTDM/iCHO was associated with a higher incidence of acute rejection (33.3% vs 14.5% at 1 year, p=0.025). Patients with PTDM/iCHO also exhibited significantly worse eGFR at all time points compared with patients without PTDM/iCHO (p=0.036) CONCLUSION: Patients with PTDM and iCHO had a higher risk of graft loss and lower renal function in paediatric kidney transplant recipients. This justifies close monitoring of metabolic complications in these patients.",
"Predictions": [
"Diabetes"
],
@@ -439,7 +556,43 @@
"Child, Preschool",
"Transplant Recipients",
"Risk Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39724381",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Oxidative balance is associated with diabetic kidney disease and mortality in adults with diabetes mellitus: Insights from NHANES database and Mendelian randomization.",
+ "Abstract": "To explore and validate the association between the oxidative balance and prevalence of diabetic kidney disease (DKD) and mortality in patients with diabetes.A large and representative sample from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 was analyzed to study the potential association between Oxidative Balance Score (OBS) and prognosis of DKD in adult diabetic patients. Weighted multivariate logistic regression analysis was conducted to examine the relationship between OBS and DKD risk. Subgroup analysis, sensitivity analysis, and mediation effect analysis were conducted to explore the effect of the covariates and assess the robustness of the findings. Mendelian randomization (MR) was employed to evaluate the correlated relationship between mitochondrial reactive oxygen species (ROS) levels and DKD at the genetic level.The highest OBS quartile showed the most significant negative correlation with DKD compared to the lowest OBS quartile (OR\u2009=\u20090.62, 95% CI 0.41-0.92, P\u2009=\u20090.017). Higher OBS was associated with a reduced risk of DKD (OR\u2009=\u20090.96; 95% CI\u2009=\u20090.93, 0.98; P\u2009<\u20090.001) and mortality (P\u2009=\u20090.021 by log-rank) in diabetic patients. This association remained robust even after excluding individual OBS components. Subgroup analysis revealed the interaction of metabolic syndrome on OBS was significant. Mediation analyses revealed that OBS's effect on DKD was independent of blood uric acid and cholesterol. Restricted cubic spline (RCS) analysis indicated a typical L-shaped relationship between OBS and DKD risk. The physical activity was identified as the core variable predicting DKD risk by two machine learning algorithms. MR showed a potential correlated relationship between ROS and microalbuminuria in DKD.The high level of oxidative balance score was negatively correlated with the risk of DKD and mortality in diabetic patients.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Female",
+ "Male",
+ "Nutrition Surveys",
+ "Diabetic Nephropathies",
+ "Middle Aged",
+ "Oxidative Stress",
+ "Adult",
+ "Prognosis",
+ "Reactive Oxygen Species",
+ "Aged",
+ "Risk Factors",
+ "Follow-Up Studies",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
"PMID": "39723173",
@@ -459,13 +612,18 @@
"Glycine",
"Nanoparticles",
"Isoquinolines"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
"PMID": "39721299",
"Title": "Radiography (London, England : 1995)",
"ArticleTitle": "Point shear wave elastography application in assessment pancreas tissue stiffness: A pilot study.",
- "Abstract": "Point shear wave elastography (pSWE) could be a useful, non-invasive tool for early detection of pancreatic changes in diabetic patients, identifying those at risk for complications. Integrating pSWE into routine diabetes check may enhance early interventions and improve outcomes.",
+ "Abstract": "Recent advancements in medical imaging, such as point shear wave elastography (pSWE), offer non-invasive methods to assess tissue stiffness and structural changes. This study explores the use of pSWE to evaluate pancreatic stiffness and dimensions in three different pancreas parts.This study was conducted at diagnostic radiology department, King Abdulaziz University Hospital, Jeddah, between June 2022 and November,2022. Thirty-one diabetic patients and thirty-one healthy controls were included. Ultrasound pSWE examination was performed using a ultrasound system (Philips Elite Epic 7) to measure stiffness across different pancreatic parts. Pancreatic stiffness was quantified in meters per second (m/s), and the dimensions of each pancreatic part were recorded. Different parameters, including age, sex, height, weight, body mass index (BMI), and comorbidities, were collected and analyzed.Diabetic patients exhibited significantly higher shear wave velocities (SWVs) compared to healthy controls, indicating increased pancreatic stiffness. The mean shear wave velocity was 1.7\u00a0m/s in diabetic versus 0.6\u00a0m/s in controls (p\u00a0<\u00a00.001). Additionally, the pancreatic head dimensions were significantly large in diabetic patients (2.1\u00a0cm vs. 1.8\u00a0cm; p\u00a0=\u00a00.003), while the body and tail part showed no significant differences. A positive correlation was found between SWVs and BMI.The findings underscore the potential of pSWE as a non-invasive diagnostic tool for early detection and monitoring of diabetes-related pancreatic alterations. Assessing pancreatic stiffness and dimensions through pSWE can help in identify patients at risk for pancreatic complications and optimize management strategies.Point shear wave elastography (pSWE) could be a useful, non-invasive tool for early detection of pancreatic changes in diabetic patients, identifying those at risk for complications. Integrating pSWE into routine diabetes check may enhance early interventions and improve outcomes.",
"Predictions": [
"Diabetes"
],
@@ -481,7 +639,12 @@
"Case-Control Studies",
"Aged",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
"PMID": "39720256",
@@ -498,13 +661,18 @@
"Animals",
"Diabetes Complications",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39720248",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Associations between non-insulin-based insulin resistance indices and diabetic nephropathy in patients with diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.",
- "Abstract": "Non-insulin-based insulin resistance indices are significantly associated with the risk of DN. The TyG index is a superior tool for assessing the risk of DN. These indices can assist in identifying patients at risk of DN, thereby enabling the implementation of more effective preventive and therapeutic strategies.",
+ "Abstract": "This study investigated the associations between non-insulin-based insulin resistance indices (METS-IR, TyG, TG/HDL, and TyG-BMI) and the risk of diabetic nephropathy (DN) in US adults with diabetes mellitus (DM).This study was based on the 1999-2018 National Health and Nutrition Examination Survey (NHANES) database and included 6,891 patients with DM for cross-sectional analysis. Multivariate adjusted models and restricted cubic spline (RCS) models were employed to assess the association between the insulin resistance index and the risk of DN. Subgroup analyses were conducted to explore the impact of different population characteristics.The results indicated that higher quartiles of METS-IR, TyG, TG/HDL, and TyG-BMI were associated with a significantly increased risk of DN. After adjusting for multiple covariates, including gender, age, and race, the associations between these indices and the risk of DN remained significant, with corresponding odds ratios (ORs) of 1.51 (95% confidence interval [CI]: 1.29-1.76), 2.06 (95% CI: 1.77-2.40), 1.61 (95% CI: 1.38-1.88), and 1.57 (95% CI: 1.35-1.84), with all P-values less than 0.001. RCS analysis indicated a nonlinear relationship between these indices and the risk of DN. The TyG index exhibited a highly consistent association with the risk of DN in all models.Non-insulin-based insulin resistance indices are significantly associated with the risk of DN. The TyG index is a superior tool for assessing the risk of DN. These indices can assist in identifying patients at risk of DN, thereby enabling the implementation of more effective preventive and therapeutic strategies.",
"Predictions": [
"Diabetes",
"Diabetes type 2"
@@ -525,13 +693,18 @@
"Diabetes Mellitus",
"Diabetes Mellitus, Type 2",
"Body Mass Index"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39719762",
"Title": "The Science of the total environment",
- "ArticleTitle": "Effects of PM",
- "Abstract": "Long-term exposure to higher levels of PM",
+ "ArticleTitle": "Effects of PM components on hypertension and diabetes: Assessing the mitigating influence of green spaces.",
+ "Abstract": "Particulate matter with diameters \u22642.5\u00a0\u03bcm (PM) is a significant air pollutant associated with hypertension and diabetes. However, the specific contributions of its components and their joint exposure with green spaces remain poorly understood, especially in developing regions.This study aims to investigate the individual and joint impacts of PM and its components on the middle-aged and older adults, identify primary risk factors, and assess disease risks associated with simultaneous exposure to green spaces.We conducted a prospective cohort study in Tianjin from 2014 to 2021, involving individuals aged \u226545\u00a0years. Satellite-based machine learning models quantified PM components, including black carbon (BC), organic matter (OM), sulfate (SO), nitrate (NO), ammonium (NH), and chloride (Cl). Residential greenness was assessed using the Normalized Difference Vegetation Index (NDVI). A time-varying Cox proportional hazards model analyzed associations between PM components and the incidence of hypertension and diabetes. The quantile g-computation model evaluated joint exposure effects and relative contributions of the components. Pollutants and NDVI were dichotomized using median values and combined to create a joint exposure model, aimed at exploring the potential effects of NDVI. Stratified analyses were performed to identify vulnerable subpopulations.Over 241,528.73 person-years of follow-up, there were 15,747 (38.34\u00a0%) new cases of hypertension and 8945 (13.59\u00a0%) new cases of diabetes. Each standard deviation (SD) increase in OM was associated with increased incidence of hypertension (hazard ratio: 1.609; 95\u00a0% confidence interval: 1.583, 1.636) and diabetes (1.484; 1.453, 1.515). Joint exposure to components is linked to higher incidence of hypertension and diabetes, with OM identified as the primary contributor. The joint exposure model indicated elevated population risk in areas with low NDVI and high PM concentrations, particularly affecting males and individuals younger than 60\u00a0years.Long-term exposure to higher levels of PM components is significantly associated with increased hypertension and diabetes, with OM potentially being the primary contributor. Joint exposure to green space may mitigate these risks. These findings highlight how PM sources impact health, informing more effective governance measures.",
"Predictions": [
"Diabetes"
],
@@ -549,13 +722,18 @@
"China",
"Aged",
"Female"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39719335",
"Title": "Wei sheng yan jiu = Journal of hygiene research",
"ArticleTitle": "[Distribution and epidemic trends of chronic multimorbidity among adult residents in 10 provinces (autonomous regions)of China in 2009-2023].",
- "Abstract": "The chronic disease status of the population is mostly combined. There are differences in the multimorbidity patterns of different age groups and genders due to their physiological differences.",
+ "Abstract": "To describe the prevalence and epidemic trends of several chronic multimorbidy among adult residents in 10 provinces(autonomous regions)of China over the past 14 years, and to analyze their multimorbidity patterns.According to the fasting blood physiological and biochemical tests, physical measurements and questionnaires of 17 000 adult residents aged 18 years and above who were surveyed in 4 rounds of follow-up surveys in 2009, 2015, 2018 and 2023, the relevant indicators and disease history information of obesity, hypertension, diabetes mellitus, dyslipidemia, hyperuricemia, and various chronic diseases were obtained. Descriptive analysis was carried out to identify and compare several common combinations of multimorbidity in the population with 2 or more chronic disease conditions and the changing trends of 4 rounds of surveys.35 712 observations from 17 000 adults revealed that the prevalence of multimorbidity in each round rose from 28.3% in 2009 to 38.9% in 2023, an increase of 10.6 percent. The prevalence of multimorbidity in different gender, age groups, and urban/rural populations showed an upward trend, while the prevalence of multimorbidity in urban and rural populations gradually tended to be the same over time. After grouping various patterns of multimorbidity, it was found that the prevalence of multimorbidity increased over the past 14 years. The main multimorbidity pattern in adults was hypertension combined with dyslipidemia and(or) other chronic disease conditions. The elderly multimorbidity pattern was mainly hypertension combined with dyslipidemia, while young and middle-aged people mainly had dyslipidemia combined with obesity or hyperuricemia.The chronic disease status of the population is mostly combined. There are differences in the multimorbidity patterns of different age groups and genders due to their physiological differences.",
"Predictions": [
"Diabetes"
],
@@ -580,1770 +758,1642 @@
"Rural Population",
"Young Adult",
"Urban Population"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
- "PMID": "39719334",
- "Title": "Wei sheng yan jiu = Journal of hygiene research",
- "ArticleTitle": "[Status and epidemic trends of major chronic metabolic diseases among adult residents in 10 provinces (autonomous regions) of China in 2009-2023].",
- "Abstract": "From 2009 to 2023, the prevalence of major chronic metabolic diseases among adults has shown a significant increasing trend, with differences in age, gender, urban-rural areas, and regions.",
+ "PMID": "39716100",
+ "Title": "BMC nephrology",
+ "ArticleTitle": "Influence of gut flora on diabetes management after kidney transplantation.",
+ "Abstract": "Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "China",
- "Female",
- "Male",
- "Adult",
- "Middle Aged",
- "Prevalence",
- "Hyperuricemia",
- "Chronic Disease",
- "Hypertension",
- "Metabolic Diseases",
- "Dyslipidemias",
- "Aged",
"Diabetes Mellitus",
- "Young Adult",
- "Rural Population",
- "Adolescent",
- "Urban Population",
- "Nutrition Surveys"
- ]
+ "Gastrointestinal Microbiome",
+ "Kidney Transplantation",
+ "Postoperative Complications"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "24"
+ }
},
{
- "PMID": "39719258",
- "Title": "International journal of pharmaceutics",
- "ArticleTitle": "Mechanistic insights of diabetic wound: Healing process, associated pathways and microRNA-based delivery systems.",
- "Abstract": "Wounds that represent one of the most critical complications can occur in individuals suffering from diabetes mellitus, and results in the need for hospitalisation and, in severe cases, require amputation. This condition is primarily characterized by infections, persistent inflammation, and delayed healing processes, which exacerbate the overall health of the patients. As per the standard mechanism, signalling pathways such as PI3K/AKT, HIF-1, TGF-\u03b2, Notch, Wnt/\u03b2-Cat, NF-\u03baB, JAK/STAT, TLR, and Nrf2 play major roles in inflammatory, proliferative and remodelling phases of wound healing. However, dysregulation of the above pathways has been seen during the healing of diabetic wounds. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of various genes and signalling pathways which are associated with the process of wound healing. In the past few years, there has been a great deal of interest in the potential of miRNAs as biological agents in the management of a number of disorders. These miRNAs have been shown to modulate expression of genes involved in the healing process of wounds. There have been previous reviews pertaining to clinical trials examining miRNAs in several disorders, but only a few clinical studies have examined involvement of miRNAs in healing of wounds. Considering the therapeutic promise, there are several obstacles concerning their instabilities and inefficient delivery into the target cells. Therefore, this review is an attempt to discuss precise roles of signalling pathways and miRNAs in different phases of wound healing, and their aberrant regulation in diabetic wounds, particularly. It has also compiled a range of delivery mechanisms as well as an overview of the latest findings pertaining to miRNAs and associated delivery systems for improved healing of diabetic wounds.",
+ "PMID": "39715497",
+ "Title": "AIDS (London, England)",
+ "ArticleTitle": "Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes.",
+ "Abstract": "People with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 antireceptor-binding domain (anti-RBD) immunoglobulin G (IgG) geometrical concentrations and neutralizing antibody capacity (nAB) in PWH with and without diabetes mellitus. Anti-RBD IgG and nAB in COVID-19-vaccinated PWH were not associated with diabetes mellitus-status or HbA1c 24\u200amonths after the initial COVID-19 vaccination.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "MicroRNAs",
"Humans",
- "Wound Healing",
- "Animals",
- "Signal Transduction",
- "Diabetes Complications",
+ "Male",
+ "COVID-19 Vaccines",
+ "Antibodies, Neutralizing",
+ "COVID-19",
+ "Female",
+ "HIV Infections",
+ "Middle Aged",
+ "Antibodies, Viral",
+ "Immunoglobulin G",
+ "SARS-CoV-2",
+ "Immunity, Humoral",
+ "Adult",
"Diabetes Mellitus",
- "Drug Delivery Systems"
- ]
+ "Vaccination",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39718458",
- "Title": "ACS applied bio materials",
- "ArticleTitle": "Glucose-Responsive Insulin Delivery via Surface-Functionalized Titanium Dioxide Nanoparticles: A Promising Theragnostic against Diabetes Mellitus.",
- "Abstract": "Glucose-dependent insulin delivery systems have been recognized as a promising approach for controlling blood sugar levels in individuals with diabetes mellitus (DM). Recently, titanium dioxide nanoparticles have garnered huge attention in scientific research for their small size and effective drug delivery capabilities. In this study, we developed alizarin (AL)-capped phenylboronic acid (PBA)-functionalized titanium dioxide nanoparticles (TiO",
+ "PMID": "39709946",
+ "Title": "Cardiorenal medicine",
+ "ArticleTitle": "The Role of Wnt3a/\u03b2-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications.",
+ "Abstract": "Diabetes mellitus is a prevalent chronic disease that is becoming increasingly common worldwide and can lead to a number of dangerous complications. The Wnt signaling pathway is important for the onset and progression of diabetes. Wnt3a is a typical Wnt ligand that can increase the stability of \u03b2-catenin, control TCF7L2 expression, promote \u03b2-cell proliferation, and reduce apoptosis.The involvement of the Wnt3a/\u03b2-catenin/TCF7L2 signaling pathway in the development of diabetes and associated problems related to the kidneys is reviewed in this article.We believe that a thorough comprehension of the molecular connections between diabetes and signaling pathways will eventually lead to improved diabetes management.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Titanium",
- "Insulin",
- "Animals",
- "Hypoglycemic Agents",
- "Particle Size",
- "Glucose",
- "Materials Testing",
- "Nanoparticles",
- "Surface Properties",
- "Biocompatible Materials",
- "Diabetes Mellitus",
- "Drug Delivery Systems",
- "Mice",
- "Diabetes Mellitus, Experimental",
"Humans",
- "Boronic Acids"
- ]
+ "Transcription Factor 7-Like 2 Protein",
+ "beta Catenin",
+ "Wnt3A Protein",
+ "Wnt Signaling Pathway",
+ "Diabetic Nephropathies",
+ "Animals",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
},
{
- "PMID": "39717102",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Higher remnant cholesterol increases the risk of coronary heart disease and diabetes in postmenopausal women.",
- "Abstract": "Our study reveals a significant positive correlation between RC levels and the prevalence of CHD, diabetes, and CHD combined with diabetes among postmenopausal women. Understanding these associations could potentially inform targeted prevention and management strategies tailored to this vulnerable population.",
+ "PMID": "39676179",
+ "Title": "The Journal of the Association of Physicians of India",
+ "ArticleTitle": "Empowering Physicians for Holistic Wellness in Diabetes Management through Mind-Body Medicine: Implications of the Psycho-Neuro-Immuno-Endocrine/Enteric Concept in Diabetes.",
+ "Abstract": "The psycho-neuro-immuno-endocrine/enteric (PNIE) axis is a fundamental concept in neuroscience, integral to the neuroendocrine system (NES). It encompasses the interactions between behavior, neurology, endocrinology, gut biology, and the immune system. These interactions regulate crucial metabolic processes like glucose, lipid, and protein metabolism, blood pressure, and various homeostatic functions, including blood pressure regulation, thermogenesis and pulmonary hypoxia detection.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Female",
- "Postmenopause",
- "Middle Aged",
- "Coronary Disease",
- "Cholesterol",
- "Aged",
+ "Holistic Health",
+ "Mind-Body Therapies",
"Diabetes Mellitus",
- "Nutrition Surveys",
- "Risk Factors",
- "Prevalence",
- "United States",
- "Cross-Sectional Studies"
- ]
+ "Neurosecretory Systems"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
},
{
- "PMID": "39717099",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Exploring the role of NLRP3 infalmmasome in diabetes: a literature review and bibliometric analysis.",
- "Abstract": "This paper has identified the hot spots and trends concerning the role of NLRP3 infalmmasome in diabetes, thereby providing a valuable reference for future research. Furthermore, it is anticipated that pyroptosis and diabetes-related diseases will become frontier research topics that may garner significant attention in the coming years.",
+ "PMID": "39667764",
+ "Title": "Zhonghua yi xue za zhi",
+ "ArticleTitle": "[The value of local antibiotics for foot infection in persons with diabetes].",
+ "Abstract": "Diabetes-related foot infections(DFI), including diabetes-related foot osteomyelitis, are generally treated with systemic antibiotics. However, systemic antibiotics are often overused and administered for excessively long periods, making patients more susceptible to multidrug-resistant bacteria. Local antibiotics may be beneficial to DFI patients. This article reviews the advantages and disadvantages, types and clinical evidence of local antibiotics in the treatment of DFI, and points out the research gaps and future research direction in this field. This article aims to provide a reference for clinicians in formulating anti-infectious treatment plans for DFI.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Bibliometrics",
"Humans",
- "NLR Family, Pyrin Domain-Containing 3 Protein",
- "Inflammasomes",
+ "Anti-Bacterial Agents",
+ "Diabetic Foot",
+ "Osteomyelitis",
"Diabetes Mellitus",
- "Animals"
- ]
+ "Anti-Infective Agents, Local"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
},
{
- "PMID": "39716287",
- "Title": "Trials",
- "ArticleTitle": "The effect of Sarcomeal\u00ae oral supplementation plus vitamin D3 on muscle parameters and metabolic factors in diabetic sarcopenia patients: study protocol of a randomized controlled clinical trial.",
- "Abstract": "Iranian Registry of Clinical Trials (ID: IRCT20230831059311N1).",
+ "PMID": "39664376",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Case report: A diabetic patient with cryptococcal meningoencephalitis complicated by post-infectious inflammatory response syndrome.",
+ "Abstract": "We report on a previously non-HIV-diagnosed, 47-year-old male diagnosed with diabetes mellitus (DM) and cryptococcal meningoencephalitis, who was referred to our institution for antifungal treatment. During the course of treatment, due to the development of refractory intracranial hypertension, Ommaya reservoirs were employed for cranial pressure reduction. The patient gradually recovered during subsequent antifungal therapy; however, symptoms worsened in the third month of treatment, leading to consideration of post-infectious inflammatory response syndrome (PIIRS) on examination. Once diagnosed, the symptoms improved significantly after approximately 130 days of treatment with additional corticosteroids.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Aged",
- "Female",
"Humans",
"Male",
"Middle Aged",
- "Administration, Oral",
- "Blood Glucose",
- "Cholecalciferol",
- "Creatine",
+ "Meningoencephalitis",
+ "Meningitis, Cryptococcal",
+ "Antifungal Agents",
+ "Diabetes Complications",
"Diabetes Mellitus",
- "Dietary Supplements",
- "Iran",
- "Muscle Strength",
- "Muscle, Skeletal",
- "Oxidative Stress",
- "Randomized Controlled Trials as Topic",
- "Sarcopenia",
- "Treatment Outcome",
- "Valerates",
- "Whey Proteins"
- ]
+ "Cryptococcosis",
+ "Cryptococcus neoformans"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
},
{
- "PMID": "39716100",
- "Title": "BMC nephrology",
- "ArticleTitle": "Influence of gut flora on diabetes management after kidney transplantation.",
- "Abstract": "Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.",
+ "PMID": "39652876",
+ "Title": "Annals of internal medicine",
+ "ArticleTitle": "Management of Hyperglycemia in Hospitalized Patients.",
+ "Abstract": "People with diabetes account for 25% of hospitalizations, or 8 million admissions annually. Poor glycemic control in the hospital is associated with increased morbidity, mortality, length of stay, and readmissions. Key considerations of inpatient diabetes management include initiation of appropriate insulin or medication regimens and frequent dose adjustments based on patient-specific factors. Inpatient diabetes management teams and new technologies are increasingly prevalent and can assist in achieving glycemic targets in the hospital. At discharge, standardized checklists should be used to ensure successful transitions of care.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
+ "Hyperglycemia",
+ "Hypoglycemic Agents",
+ "Hospitalization",
+ "Insulin",
"Diabetes Mellitus",
- "Gastrointestinal Microbiome",
- "Kidney Transplantation",
- "Postoperative Complications"
- ]
+ "Blood Glucose",
+ "Glycemic Control"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39715819",
- "Title": "Scientific reports",
- "ArticleTitle": "The effect of an educational program on the knowledge and practices of diabetic patients regarding sharps waste disposal at home.",
- "Abstract": "The disposal of sharp waste generated at home by diabetic patients poses a major public health problem. This study evaluated an educational program designed to improve patients' knowledge and practices around sharps disposal. A non-equivalent quasi-experimental study was performed at a main diabetic center in Egypt on 100 participants divided into intervention and non-intervention groups. The effect of the interventional program was tested by the evaluation of the improvement in participants' knowledge and practice after two and four months of the program. Initially, there were no differences in knowledge or practice scores between the groups. After the implementation of the program, there was a noticeable difference in subjects' knowledge levels and scores between the two groups, with the intervention group significantly outperforming the non-intervention group (p\u2009<\u20090.001). There was a significant improvement in overall practice scores in the intervention group across post-intervention visits, and they registered a score of 14/16, which matches a good practice level, while in the non-intervention group, the score remained unchanged at 4.4/16, which corresponds to a poor practice level (p\u2009<\u20090.001). These findings suggest that educational programs can effectively increase diabetic patients' knowledge and improve their sharps waste disposal practices.Clinical trial registration number: PACTR202310841894237. Date: 05 October 2023, \"retrospectively registered\".",
+ "PMID": "39652680",
+ "Title": "Computers, informatics, nursing : CIN",
+ "ArticleTitle": "Implementation of Diabetic Remote Patient Monitor for Underserved Population.",
+ "Abstract": "A nurse-led interprofessional clinic adopted the use of remote patient monitoring (RPM) for glucose monitoring to better serve their patient population of uninsured patients with uncontrolled diabetes. The adoption of the RPM system required an infrastructure design to connect multiple data points and adapt to the needs of the clinic's unique patient population for a seamless provider and patient experience. Implementation requirements were addressed in three phases: protocol adaptation, enrollment workflow, and clinic management of RPM patients.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Adult",
- "Female",
"Humans",
- "Male",
- "Middle Aged",
"Diabetes Mellitus",
- "Egypt",
- "Health Knowledge, Attitudes, Practice",
- "Patient Education as Topic"
- ]
+ "Blood Glucose Self-Monitoring",
+ "Vulnerable Populations",
+ "Telemedicine",
+ "Medically Underserved Area",
+ "Medically Uninsured"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39715497",
- "Title": "AIDS (London, England)",
- "ArticleTitle": "Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes.",
- "Abstract": "People with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 antireceptor-binding domain (anti-RBD) immunoglobulin G (IgG) geometrical concentrations and neutralizing antibody capacity (nAB) in PWH with and without diabetes mellitus. Anti-RBD IgG and nAB in COVID-19-vaccinated PWH were not associated with diabetes mellitus-status or HbA1c 24\u200amonths after the initial COVID-19 vaccination.",
+ "PMID": "39651985",
+ "Title": "Diabetes care",
+ "ArticleTitle": "15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "COVID-19 Vaccines",
- "Antibodies, Neutralizing",
- "COVID-19",
+ "Pregnancy",
"Female",
- "HIV Infections",
- "Middle Aged",
- "Antibodies, Viral",
- "Immunoglobulin G",
- "SARS-CoV-2",
- "Immunity, Humoral",
- "Adult",
+ "Standard of Care",
+ "Pregnancy in Diabetics",
"Diabetes Mellitus",
- "Vaccination",
- "Aged"
- ]
+ "Diabetes, Gestational",
+ "Practice Guidelines as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39714194",
- "Title": "European journal of neurology",
- "ArticleTitle": "Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus.",
- "Abstract": "Our study revealed that in patients with AIS and diabetes under 55, higher admission hbA1c was associated with an increased risk of the 1-year primary outcome, while in patients aged over 85, lower HbA1c value (\u22646.0%) may be associated with an increased risk of vascular events. The results of our study suggest the age-stratified, heterogeneous associations between admission HbA1c and 1-year vascular outcomes in patients with AIS and diabetes.",
+ "PMID": "39651981",
+ "Title": "Diabetes care",
+ "ArticleTitle": "6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Aged",
- "Male",
- "Female",
- "Middle Aged",
- "Ischemic Stroke",
- "Aged, 80 and over",
- "Glycated Hemoglobin",
+ "Hypoglycemia",
"Diabetes Mellitus",
- "Age Factors",
+ "Standard of Care",
+ "Glycemic Control",
"Blood Glucose",
- "Prospective Studies"
- ]
+ "Practice Guidelines as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39714134",
- "Title": "Journal of materials chemistry. B",
- "ArticleTitle": "A step towards non-invasive diagnosis of diabetes mellitus using ",
- "Abstract": "The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF-MXene (Ni",
+ "PMID": "39651980",
+ "Title": "Diabetes care",
+ "ArticleTitle": "14. Children and Adolescents: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus",
- "Saliva",
- "Metal-Organic Frameworks",
- "Transistors, Electronic",
- "Glucose",
- "Electrodes",
- "Biosensing Techniques",
- "Electrochemical Techniques",
- "Nickel",
- "Particle Size"
- ]
+ "Child",
+ "Adolescent",
+ "Standard of Care",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39710070",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Health disparities in diabetes treatment: The challenge of G6PD deficiency.",
- "Abstract": "This research highlights serious gaps in the management of G6PD-deficient patients with diabetes, who suffer from insufficient medication management and higher rates of complications. These findings underscore the need to account for G6PD deficiency in diabetes treatment to ensure equitable and effective healthcare for this vulnerable population.",
+ "PMID": "39651979",
+ "Title": "Diabetes care",
+ "ArticleTitle": "17. Diabetes Advocacy: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
- "Diabetes",
- "Diabetes type 2"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Glucosephosphate Dehydrogenase Deficiency",
- "Female",
- "Male",
- "Middle Aged",
- "Glycated Hemoglobin",
- "Hypoglycemic Agents",
- "Adult",
- "Aged",
- "Blood Glucose",
- "Cohort Studies",
- "Healthcare Disparities",
- "Diabetes Complications",
"Diabetes Mellitus",
- "Diabetes Mellitus, Type 2"
- ]
+ "Standard of Care",
+ "Practice Guidelines as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39709946",
- "Title": "Cardiorenal medicine",
- "ArticleTitle": "The Role of Wnt3a/\u03b2-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications.",
- "Abstract": "We believe that a thorough comprehension of the molecular connections between diabetes and signaling pathways will eventually lead to improved diabetes management.",
+ "PMID": "39651978",
+ "Title": "Diabetes care",
+ "ArticleTitle": "7. Diabetes Technology: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Transcription Factor 7-Like 2 Protein",
- "beta Catenin",
- "Wnt3A Protein",
- "Wnt Signaling Pathway",
- "Diabetic Nephropathies",
- "Animals",
- "Diabetes Mellitus"
- ]
+ "Diabetes Mellitus",
+ "Standard of Care"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39709804",
- "Title": "Vaccine",
- "ArticleTitle": "Seasonal influenza vaccination coverage and the social determinants of influenza vaccination among people over 50 with diabetes in Europe: Analyzing population-based SHARE data for the 2019-2020 and 2021-2022 influenza seasons.",
- "Abstract": "Despite the increase, the average European influenza vaccination level remains below the EU target of 75\u00a0%. This study fills an important data gap for the ECDC by providing information on influenza vaccination coverage rates among people over 50 with diabetes. The findings highlight the crucial role of a robust social and healthcare system in promoting vaccination. To improve vaccination rates, the ECDC-funded VENICE network should enhance vaccination knowledge, address socioeconomic disparities by strengthening local programs and funding, and collaborate with various stakeholders to develop regional strategies.",
+ "PMID": "39651977",
+ "Title": "Diabetes care",
+ "ArticleTitle": "13. Older Adults: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Vaccination Coverage",
- "Cross-Sectional Studies",
- "Influenza, Human",
- "Male",
- "Influenza Vaccines",
- "Female",
- "Europe",
- "Middle Aged",
- "Aged",
+ "Standard of Care",
"Diabetes Mellitus",
- "Seasons",
- "Vaccination",
- "Social Determinants of Health",
+ "Aged",
"Aged, 80 and over"
- ]
- },
- {
- "PMID": "39709395",
- "Title": "BMC medical informatics and decision making",
- "ArticleTitle": "A software tool for applying Bayes' theorem in medical diagnostics.",
- "Abstract": "The software tool\u00a0enhances the estimation and facilitates the comparison of Bayesian diagnostic measures, which are critical for medical practice. It provides a framework for their uncertainty quantification and assists in understanding and applying Bayes' theorem in medical diagnostics.",
- "Predictions": [
- "Diabetes"
],
- "MeshTerms": [
- "Bayes Theorem",
- "Humans",
- "Software",
- "Diabetes Mellitus"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39709343",
- "Title": "BMC primary care",
- "ArticleTitle": "The profound impact of COVID-19 on the control and care of diabetic patients: a comprehensive retrospective cohort study.",
- "Abstract": "The COVID-19 pandemic disrupted healthcare systems globally, and the consequences on health and mortality were not only due to the direct impact of the virus, but also to the modifications in priorities. These interruptions in inconsistent care, had consequences for non-communicable diseases (NCDs) like diabetes. Future strategic plans should be prepared and implemented to manage NCD cases in case of pandemics.",
+ "PMID": "39651972",
+ "Title": "Diabetes care",
+ "ArticleTitle": "16. Diabetes Care in the Hospital: Standards of Care in Diabetes-2025.",
+ "Abstract": "The American Diabetes Association (ADA) \"Standards of Care in Diabetes\" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Middle Aged",
- "Retrospective Studies",
- "Male",
- "Adult",
- "Female",
- "Aged",
- "Glycated Hemoglobin",
"Diabetes Mellitus",
- "Aged, 80 and over",
- "Oman",
- "Body Mass Index",
- "Blood Pressure",
- "Young Adult",
- "SARS-CoV-2",
- "Hypertension",
- "Pandemics"
- ]
+ "Standard of Care",
+ "Hospitals",
+ "Practice Guidelines as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39707324",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Association of triglyceride-glucose index and diabesity: evidence from a national longitudinal study.",
- "Abstract": "This national longitudinal study in China provides evidence that a higher TyG index is associated with an increased risk of developing diabesity.",
+ "PMID": "39645620",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Drug repositioning and its aspects in clinical diabetology].",
+ "Abstract": "",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Triglycerides",
- "Longitudinal Studies",
- "Male",
- "Middle Aged",
- "Female",
- "Blood Glucose",
- "China",
- "Aged",
- "Obesity",
- "Risk Factors",
- "Insulin Resistance",
+ "Hypoglycemic Agents",
+ "Drug Repositioning",
"Diabetes Mellitus",
- "Proportional Hazards Models"
- ]
+ "Diabetes Mellitus, Type 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "8"
+ }
},
{
- "PMID": "39707271",
- "Title": "BMC endocrine disorders",
- "ArticleTitle": "Erectile dysfunction and associated factors among patients with diabetes in Public hospitals of Harari region, Eastern Ethiopia: modified poisson regression model.",
- "Abstract": "More than three-fourths of the participants had erectile dysfunction. Significant factors associated with erectile dysfunction included age 35 years and above, depression, current hat use, and low and medium social support level. The management of erectile dysfunction should be integrated into routine medical care in diabetic follow-up clinics, with special attention for those participants aged 35 years and above, who have depression, currently use Khat, and have low-level social support.",
+ "PMID": "39631417",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[Endocrinology, diabetology and metabolism in the 150 years of the DMW - A long and sustainable relationship].",
+ "Abstract": "The DMW is celebrating its 150th anniversary - and this period is precisely when endocrinology and diabetology evolved from the first experiments to molecular biology, genetic, and bioinformatics research. The DMW has always accompanied this process with numerous important publications, some of which are highlighted in this article.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Humans",
- "Male",
- "Erectile Dysfunction",
- "Ethiopia",
- "Cross-Sectional Studies",
- "Adult",
- "Middle Aged",
- "Hospitals, Public",
- "Prevalence",
- "Risk Factors",
+ "History, 20th Century",
+ "Endocrinology",
+ "History, 19th Century",
+ "History, 21st Century",
"Diabetes Mellitus",
- "Poisson Distribution",
- "Young Adult",
- "Diabetes Complications",
- "Surveys and Questionnaires"
- ]
+ "Humans",
+ "Germany",
+ "Periodicals as Topic",
+ "Societies, Medical"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "5"
+ }
},
{
- "PMID": "39707185",
- "Title": "Molecular medicine (Cambridge, Mass.)",
- "ArticleTitle": "Elucidating the role of gut microbiota metabolites in diabetes by employing network pharmacology.",
- "Abstract": "Gut microbiota metabolites primarily exert their therapeutic effects on diabetes through the IL6, AKT1, and PPARG targets. The mechanisms of gut microbiota metabolites regulating DM might involve signaling pathways such as IL-17 pathways, HIF-1 pathways and VEGF pathways.",
+ "PMID": "39581640",
+ "Title": "The Orthopedic clinics of North America",
+ "ArticleTitle": "Comorbidities in Total Hip and Knee Arthroplasty Patients: When Is It Okay to Say No?",
+ "Abstract": "Preoperative optimization of modifiable risk factors for total hip and knee arthroplasty remains a foundational cornerstone in reducing postoperative complications and enhancing patient outcomes. With an increasing prevalence of high-risk comorbidities among total joint arthroplasty patients with morbid obesity (body mass index \u226540\u00a0kg/m2), uncontrolled diabetes (hemoglobin A1c\u00a0\u2265\u00a07.5%), and active smoking and tobacco use, many joint arthroplasty surgeons face complex ethical decisions when surgical intervention poses a higher risk for potential harm. Creating definitive numerical cutoffs may lead to access-to-care issues with a difficult balance between helping and harming patients.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Gastrointestinal Microbiome",
"Humans",
- "Diabetes Mellitus",
- "Protein Interaction Maps",
- "Network Pharmacology",
- "Proto-Oncogene Proteins c-akt",
- "Metabolome",
- "PPAR gamma",
- "Signal Transduction",
- "Metabolomics",
- "Computational Biology"
- ]
+ "Arthroplasty, Replacement, Hip",
+ "Arthroplasty, Replacement, Knee",
+ "Comorbidity",
+ "Postoperative Complications",
+ "Risk Factors",
+ "Obesity, Morbid",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "25"
+ }
},
{
- "PMID": "39706370",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study.",
- "Abstract": "The ADA criteria can identify individuals with elevated haemoglobinA1c (HbA1c) levels when the 1-hour plasma glucose (1-h PG) stay within the normal range, while the IDF criteria can identify subjects with impaired insulin sensitivity and secretion when fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and HbA1c values are in the normal range.",
+ "PMID": "39556456",
+ "Title": "Diabetes",
+ "ArticleTitle": "Diabetes Associated With Maternally Inherited Diabetes and Deafness (MIDD): From Pathogenic Variant to Phenotype.",
+ "Abstract": "Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder characterized primarily by hearing impairment and diabetes. m.3243A>G, the most common phenotypic variant, causes a complex rewiring of the cell with discontinuous remodeling of both mitochondrial and nuclear genome expressions. We propose that MIDD depends on a combination of insulin resistance and impaired \u03b2-cell function that occurs in the presence of high skeletal muscle heteroplasmy (approximately \u226560%) and more moderate cell heteroplasmy (\u223c25%-72%) for m.3243A>G. Understanding the complex mechanisms of MIDD is necessary to develop disease-specific management guidelines that are presently lacking.",
"Predictions": [
"Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Middle Aged",
- "Glucose Tolerance Test",
- "Adult",
- "Blood Glucose",
- "Hyperglycemia",
- "Glycated Hemoglobin",
- "Insulin Resistance",
- "China",
+ "Deafness",
+ "Mitochondrial Diseases",
+ "Phenotype",
+ "DNA, Mitochondrial",
"Diabetes Mellitus",
+ "Insulin Resistance",
"Diabetes Mellitus, Type 2",
- "Aged",
- "Insulin",
- "Prevalence"
- ]
- },
- {
- "PMID": "39705195",
- "Title": "The American journal of managed care",
- "ArticleTitle": "Diabetes, cardiorenal, and metabolic multispecialty practice recommendations and early intensive management of cardio-renal-metabolic disease.",
- "Abstract": "In recent years, evidence has continued to mount showing a strong relationship between diabetes, cardiovascular disease, and chronic kidney disease. This, in turn, has driven a shift to a more integrated and holistic approach in the treatment of patients with cardio-renal-metabolic (CRM) disease. The 2022 Diabetes, Cardiorenal, and Metabolic (DCRM) multispecialty practice recommendations were the first multispecialty consensus on the comprehensive management of patients with diabetes, cardiorenal, and/or metabolic diseases, providing evidence-based recommendations that are simple to implement. The recommendations provide guidance on assessments and treatments, including both lifestyle therapy and pharmacotherapy, for patients across the DCRM spectrum, and are an invaluable tool for clinicians who need to develop treatment plans for complex patients with cardio-renal-metabolic disease. This article reviews the key elements of the DCRM recommendations and summarizes the updates included in the DCRM 2.0.",
- "Predictions": [
- "Diabetes"
+ "Maternal Inheritance",
+ "Muscle, Skeletal"
],
- "MeshTerms": [
- "Humans",
- "Cardio-Renal Syndrome",
- "Diabetes Mellitus",
- "Metabolic Diseases",
- "Practice Guidelines as Topic",
- "Renal Insufficiency, Chronic"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39703865",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Association of serum uric acid to high-density lipoprotein cholesterol ratio with all-cause and cardiovascular mortality in patients with diabetes or prediabetes: a prospective cohort study.",
- "Abstract": "Higher UHR was correlated with increased all-cause and cardiovascular mortality in patients with diabetes or prediabetes.",
+ "PMID": "39556160",
+ "Title": "Reviews in endocrine & metabolic disorders",
+ "ArticleTitle": "Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources.",
+ "Abstract": "Individuals in the United States with lower economic resources face a disproportionate burden of obesity and co-morbid conditions. This review summarizes the efficacy of MR programs for the treatment of obesity and diabetes and alerts clinicians to potential barriers and facilitators to the uptake of such programs so they may tailor their prescriptive approach. Implementation of effective behavioral and lifestyle interventions for obesity and diabetes in low-income settings is fraught with barriers and under-studied. The dearth of data on the use of MR programs in populations with low economic resources highlights a key area for future investigation.",
"Predictions": [
"Diabetes",
- "Cardiovascular diseases"
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Prediabetic State",
- "Uric Acid",
- "Male",
- "Female",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Cholesterol, HDL",
- "Prospective Studies",
- "Adult",
- "Biomarkers",
+ "Obesity",
+ "United States",
"Diabetes Mellitus",
- "Prognosis",
- "Aged",
- "Nutrition Surveys",
- "Cohort Studies",
- "Follow-Up Studies",
- "Cause of Death",
- "Risk Factors"
- ]
+ "Poverty",
+ "Diabetes Mellitus, Type 2",
+ "Patient Compliance"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39703057",
- "Title": "Journal of helminthology",
- "ArticleTitle": "Association of ",
- "Abstract": "Previous studies have shown that helminth infection protects against the development of diabetes mellitus (DM), possibly related to the hygiene hypothesis. However, studies involving ",
+ "PMID": "39548606",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Muraqabah: Meaningful Adjuvant Therapy for Metabolic Health.",
+ "Abstract": "Muraqabah is an Islamic form of mindful meditation, prayerful meditation or religious meditation. This is a means of connecting to God, while being mindful of his presence. It also implies seclusion. Muraqabah may be used as means of improving physical and mental health in persons with metabolic diseases such as diabetes and hypertension. In this editorial. We share the need to study and research this potential therapy, we share pragmatic ideas as to how muraqabah can be introduced in clinical practice.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Strongyloides stercoralis",
- "Strongyloidiasis",
- "Animals",
"Humans",
+ "Meditation",
+ "Islam",
+ "Hypertension",
+ "Mindfulness",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "16"
+ }
},
{
- "PMID": "39702258",
- "Title": "BMC research notes",
- "ArticleTitle": "Comparison of nasopharyngeal bacteriological profile between patients with diabetes and healthy individuals in Accra, Ghana.",
- "Abstract": "The nasopharyngeal bacterial flora of PLWD in Accra seems to have comparable diversities with those of non-diabetics. Nonetheless, the PLWD had a higher carriage rate of Acinetobacter baumannii but seem to have some protection against carriage of Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa.",
+ "PMID": "39541587",
+ "Title": "Preventing chronic disease",
+ "ArticleTitle": "Telemedicine Use Among Adults With and Without Diagnosed Prediabetes or Diabetes, National Health Interview Survey, United States, 2021 and 2022.",
+ "Abstract": "We analyzed 2021 and 2022 National Health Interview Survey data to describe the prevalence of past 12-month telemedicine use among US adults with no prediabetes or diabetes diagnosis, diagnosed prediabetes, and diagnosed diabetes. In 2021 and 2022, telemedicine use prevalence was 34.1% and 28.2% among adults without diagnosed diabetes or prediabetes, 47.6% and 37.6% among adults with prediabetes, and 52.8% and 39.4% among adults with diabetes, respectively. Differences in telemedicine use were identified by region, urbanicity, insurance status, and education among adults with prediabetes or diabetes. Findings suggest that telemedicine use can be improved among select populations with prediabetes or diabetes.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Nasopharynx",
- "Male",
- "Female",
- "Case-Control Studies",
+ "Prediabetic State",
+ "Telemedicine",
+ "United States",
"Adult",
+ "Female",
+ "Male",
"Middle Aged",
- "Ghana",
"Diabetes Mellitus",
+ "Health Surveys",
"Aged",
- "Bacteria",
"Young Adult",
- "Respiratory Tract Infections"
- ]
+ "Adolescent",
+ "Prevalence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "14"
+ }
},
{
- "PMID": "39702047",
- "Title": "BMC public health",
- "ArticleTitle": "Exploring mHealth app utilization for diabetes self-management: survey insights from a northern district in Malaysia.",
- "Abstract": "The findings highlight the underutilization of mHealth apps for diabetes management despite their perceived usefulness. Challenges faced by users and non-users underscore the need for more awareness, thus encourage widespread acceptance and usage of mHealth apps in diabetes care.",
+ "PMID": "39516019",
+ "Title": "Casopis lekaru ceskych",
+ "ArticleTitle": "Glycation in diabetes: is it the same in all patients?",
+ "Abstract": "Glycation plays a crucial role in the development of chronic vascular complications in diabetes. The total individual glycation is a result of interaction between proglycation and deglycation mechanisms and can be expressed by hemoglobin glycation index (HGI). There is increasing evidence that patients with higher glycation (and higher HGI) suffer from more frequent diabetic complications. In practice, it would therefore be advantageous to identify and treat such patients to stricter glycemic goals.",
"Predictions": [
- "Diabetes",
- "Diabetes type 2"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Female",
- "Malaysia",
- "Male",
- "Mobile Applications",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Adult",
- "Telemedicine",
- "Self-Management",
- "Surveys and Questionnaires",
+ "Glycated Hemoglobin",
+ "Diabetic Angiopathies",
"Diabetes Mellitus",
- "Aged",
- "Diabetes Mellitus, Type 2",
- "Young Adult"
- ]
+ "Glycation End Products, Advanced"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39700129",
- "Title": "PloS one",
- "ArticleTitle": "Sociodemographic factors, clinical characteristics, outcomes and short-term follow-up in COVID-19 patients with new onset hyperglycemia and pre-existing diabetes on admission in a tertiary-care hospital in Bangladesh.",
- "Abstract": "In conclusion, our investigation illuminates the clinical trajectory of new-onset hyperglycemia in the context of COVID-19 and reinforces the necessity for diligent monitoring and management post-discharge. Therefore, close monitoring and follow-up of COVID-19 patients is recommended for the early detection and management of hyperglycemia and the prevention of diabetes development in the long run.",
+ "PMID": "39515917",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Ecology and therapeutic education for patients with diabetes].",
+ "Abstract": "Healthcare accounts for 8% of French carbon emissions. Diabetes is a disease involving the use of a large number of treatments and medical devices, and its prevalence is constantly increasing. Thanks to therapeutic patient education, nurses can help limit and manage waste. Communication tools using social marketing can contribute to behavioral change.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Male",
- "Female",
- "Bangladesh",
- "Hyperglycemia",
- "Middle Aged",
- "Tertiary Care Centers",
+ "Patient Education as Topic",
"Diabetes Mellitus",
- "Prospective Studies",
- "Adult",
- "Follow-Up Studies",
- "Aged",
- "SARS-CoV-2",
- "Hospitalization",
- "Patient Discharge",
- "Risk Factors",
- "Socioeconomic Factors",
- "Hospital Mortality"
- ]
+ "France"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39699704",
- "Title": "Current atherosclerosis reports",
- "ArticleTitle": "Statin Use and Hyperglycemia: Do Statins Cause Diabetes?",
- "Abstract": "Since initial reporting of statin-induced hyperglycemia and NODM, the totality of available data corroborates an association between incident diabetes and statin use. A consensus that high-intensity statin and individuals with obesity or glycemic parameters approximating diabetes thresholds constitute the majority of risk exists. Alterations in insulin signaling, glucose transport and gastrointestinal microbiota are leading hypotheses underlying the mechanisms of statin-induced hyperglycemia. The probability of NODM based on an individual's risk factors and statin specific properties can be anticipated. This risk needs to be contextualized with the risk of ASCVD. In order to effectively adjudicate the risk of NODM, improvement in formulating and ultimately conveying a comprehensive ASCVD risk assessment to patients is necessary.",
+ "PMID": "39515916",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Corticosteroid therapy: a multidisciplinary approach to patient care?].",
+ "Abstract": "As corticosteroids can cause diabetes, it is important to assess the benefit-risk balance for patients before introducing them, and to monitor the development of hyperglycemia in people treated with this therapeutic class. As soon as cortico-induced diabetes is discovered, multidisciplinary, cross-disciplinary management improves follow-up conditions.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
- "Hyperglycemia",
+ "Patient Care Team",
+ "Adrenal Cortex Hormones",
"Diabetes Mellitus",
- "Risk Factors",
- "Atherosclerosis",
- "Blood Glucose"
- ]
+ "Glucocorticoids"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39699431",
- "Title": "Revista gaucha de enfermagem",
- "ArticleTitle": "Educational technologies to promote the quality of life of people with diabetes: quasi-experimental study.",
- "Abstract": "the use of educational technologies in educational interventions demonstrated an improvement in the quality of life of people living with diabetes.",
+ "PMID": "39515915",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Diabetes and mental health: towards integrated care].",
+ "Abstract": "The reduced life expectancy and higher mortality of people suffering from mental disorders compared to the general population represent a major public health challenge. Numerous individual and collective factors contribute to this inequality, particularly in the case of chronic pathologies such as diabetes. Integrated, coordinated care would help reduce health disparities and guarantee equitable access to care for this vulnerable population.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Quality of Life",
"Humans",
- "Male",
- "Female",
- "Middle Aged",
+ "Delivery of Health Care, Integrated",
+ "Mental Disorders",
"Diabetes Mellitus",
- "Patient Education as Topic",
- "Educational Technology",
- "Adult",
- "Aged",
- "Surveys and Questionnaires",
- "Controlled Before-After Studies"
- ]
+ "Health Services Accessibility"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39698032",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Non-linear dose-response relationship between the visceral adiposity index and diabetes in adults with normoglycemia: a cohort study.",
- "Abstract": "Our cohort study validated the positive and non-linear relationship between the VAI and diabetes in normoglycemic adults in Japan. The relevance was more marked in women than in men. For those with a VAI below 4.67, a further reduction in the VAI could potentially lead to a significant decrease in diabetes risk.",
+ "PMID": "39515913",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[\"We welcome people in very precarious situations to the Pass\"].",
+ "Abstract": "An interview with a nurse provides a better understanding of the specific features of a permanent healthcare access service, the people encountered and the skills to be developed for the job. In the context of diabetes, the testimony of Marjorie El Darwiche Sychareunh, who graduated in 2010 and has been working in permanent healthcare access service since September 2023, makes it easier to identify the resources available to support these patients, who are often in a very precarious situation.",
"Predictions": [
- "Diabetes",
- "Diabetes type 2"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Intra-Abdominal Fat",
- "Japan",
- "Cohort Studies",
- "Obesity, Abdominal",
- "Adiposity",
- "Diabetes Mellitus",
- "Risk Factors",
- "Blood Glucose",
- "Longitudinal Studies",
- "Diabetes Mellitus, Type 2"
- ]
+ "Health Services Accessibility",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39696515",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "Gender differences in the association between the uric acid to high-density lipoprotein cholesterol ratio and diabetes risk: a mediation analysis of c-reactive protein, triglycerides, and insulin resistance.",
- "Abstract": "This study demonstrates that the association between UHR and diabetes risk exhibits gender differences, with higher diabetes risk observed in women, while men show stronger mediation effects in insulin resistance, lipid metabolism, and inflammatory response.",
+ "PMID": "39515912",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Developing cultural competence for better support].",
+ "Abstract": "Culture, in its broadest sense, can have an impact on diabetes management. Taking into account cultural particularities in the care of patients seems essential to offering them care that is equitable and meaningful to them. Developing nurses' cultural competence through reflection, training and experience could be a lever enabling them to achieve this objective of quality and relevance of care.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Uric Acid",
- "C-Reactive Protein",
- "Male",
- "Female",
- "Insulin Resistance",
- "Triglycerides",
- "Cholesterol, HDL",
- "Adult",
- "Middle Aged",
- "Risk Factors",
- "Sex Factors",
- "Diabetes Mellitus",
- "Mediation Analysis",
- "Biomarkers",
- "Sex Characteristics"
- ]
+ "Cultural Competency",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39696157",
- "Title": "BMC endocrine disorders",
- "ArticleTitle": "Identify unmet needs in diabetes care in Shandong, China: a secondary analysis of a cross-sectional study using cascade of care framework.",
- "Abstract": "A significant unmet need exists for diabetes adults from screening to management, particularly the comprehensive management of glycemia, BP and LDL-c levels among those with multimorbidity. Tailored strategies and appropriate allocation of healthcare resource is needed to addressing gaps in care continuum and reduce long-term disease burden.",
+ "PMID": "39515911",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Telecare: experience feedback for monitoring people with diabetes].",
+ "Abstract": "Telecare is a telehealth practice open to medical auxiliaries and pharmacists. In semi-structured interviews, nurses shared their experiences. The results show that new skills are being mobilized to meet the needs of diabetic patients. However, there are still obstacles to be overcome, such as a lack of digital skills and organizational and technical difficulties, which need to be taken into account if we are to continue deploying this practice.",
"Predictions": [
- "Diabetes",
- "Diabetes type 2"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Cross-Sectional Studies",
- "China",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
- "Aged",
- "Health Services Needs and Demand",
"Diabetes Mellitus",
- "Young Adult",
- "Blood Glucose",
- "Diabetes Mellitus, Type 2",
- "Mass Screening",
- "Adolescent"
- ]
+ "Telemedicine"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39696101",
- "Title": "BMC endocrine disorders",
- "ArticleTitle": "Assessment of sex disparities in prevalence of diagnosed and undiagnosed diabetes mellitus: results from the Bangladesh demographic and health survey data.",
- "Abstract": "This study reveals that diabetes prevalence in Bangladesh is influenced by various risk factors, with distinct impacts on men and women. Women living in Dhaka who are unemployed are at a significantly higher risk of both diagnosed and undiagnosed diabetes compared to men. To effectively combat the rising diabetes rate, we must implement targeted interventions that address these sex-specific disparities. These interventions should focus on age, wealth, regional variations, and especially on unemployed women in Dhaka, considering their heightened risk.",
+ "PMID": "39515910",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The evolution of diabetes healthcare providers].",
+ "Abstract": "Healthcare providers provide technical support for insulin pump therapy. In practice, they often provide much more than just logistical support. The complexity of day-to-day diabetes management, and the innovative systems that have emerged in recent years, make the provider a key partner. The changing needs of both patients and pump-initiating centers call for a transformation of their role.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Bangladesh",
- "Adult",
- "Prevalence",
- "Diabetes Mellitus",
- "Middle Aged",
- "Health Surveys",
- "Young Adult",
- "Risk Factors",
- "Sex Factors",
- "Undiagnosed Diseases",
- "Adolescent",
- "Aged"
- ]
+ "Insulin Infusion Systems",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39695649",
- "Title": "BMC medical informatics and decision making",
- "ArticleTitle": "An explainable analysis of diabetes mellitus using statistical and artificial intelligence techniques.",
- "Abstract": "An integrated analysis of DM using a variety of methodologies is critical for timely detection of the disease and informed clinical decision-making.",
+ "PMID": "39515909",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Therapeutic autonomy for residents living with diabetes in institutions].",
+ "Abstract": "The autonomy of elderly people living with diabetes must be encouraged, even when they are institutionalized. A comprehensive assessment is the first step towards maintaining this therapeutic autonomy. Tools and procedures are available to promote personalized diabetes care plans.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Artificial Intelligence",
+ "Personal Autonomy",
+ "Aged",
"Diabetes Mellitus",
- "Neural Networks, Computer",
- "Middle Aged",
- "Female",
- "Male",
- "Models, Statistical",
- "Support Vector Machine",
- "Adult",
- "Aged"
- ]
+ "Nursing Homes"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39695632",
- "Title": "BMC health services research",
- "ArticleTitle": "Barriers and facilitators in the acquisition of diabetes knowledge among tertiary-care nurses in central and southern Malawi: an exploratory-descriptive qualitative study.",
- "Abstract": "The study brings to light various challenges and opportunities in the acquisition of diabetes knowledge among tertiary-care nurses in Malawi. Given our study results, we believe that cost-effective measures can be utilised to address the barriers to the acquisition of diabetes knowledge among nurses. This is a crucial step towards ensuring that nurses are knowledgeable and competent in the provision of care for patients with diabetes in low-resource countries.",
+ "PMID": "39515907",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Occupational health nurse: from primary prevention to job retention].",
+ "Abstract": "The role of the occupational health nurse in promoting health and preventing occupational exclusion, particularly for diabetic workers, is often overlooked. And yet, the occupational health nurse plays a key role in assessing the impact of the disease on professional activity, identifying risks and proposing appropriate preventive measures. Keeping people with diabetes in work is essential to encourage better compliance with treatment.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Malawi",
- "Qualitative Research",
- "Female",
+ "Occupational Health Nursing",
+ "Primary Prevention",
"Diabetes Mellitus",
- "Focus Groups",
- "Health Knowledge, Attitudes, Practice",
- "Adult",
- "Male",
- "Nursing Staff, Hospital",
- "Tertiary Care Centers",
- "Clinical Competence",
- "Middle Aged"
- ]
+ "Nurse's Role",
+ "Job Security"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39695379",
- "Title": "BMC medical research methodology",
- "ArticleTitle": "Robustness assessment of regressions using cluster analysis typologies: a bootstrap procedure with application in state sequence analysis.",
- "Abstract": "Investigating the relationship between trajectory patterns and covariates is of interest in many situations. However, it is a challenging task with potential pitfalls. Our Robustness Assessment of Regression using Cluster Analysis Typologies (RARCAT) may assist in ensuring the robustness of such association studies. The method is applicable wherever clustering is combined with regression analysis, so its relevance goes beyond State Sequence Analysis.",
+ "PMID": "39515906",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Evolving skills for people with diabetes].",
+ "Abstract": "Drawing on nursing knowledge, professionals develop certains skills with people with diabetes. Some, such as the educational posture, seem to have been mastered by diabetes caregivers. But changes in the healthcare system, the advent of new technologies and climate change are prompting nurses to reinvent their daily practice.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Cluster Analysis",
- "Regression Analysis",
- "Models, Statistical",
- "Algorithms",
"Diabetes Mellitus",
- "Data Interpretation, Statistical"
- ]
+ "Patient Education as Topic",
+ "Clinical Competence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39693799",
- "Title": "Psychiatry research",
- "ArticleTitle": "Association between triglyceride-glucose (TyG) index and the incidence of depression in US adults with diabetes or pre-diabetes.",
- "Abstract": "There is a linear positive association between the TyG index and the incidence of depression in populations with diabetes or pre-diabetes.",
+ "PMID": "39510537",
+ "Title": "Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association",
+ "ArticleTitle": "Ocular Motor Mononeuropathies in Diabetes Mellitus: A Brief Review.",
+ "Abstract": "Ocular motor mononeuropathies affect cranial nerves III, IV and VI and are more frequent in diabetes mellitus, with oculomotor nerve involvement being predominant. This narrative brief review discusses the clinical manifestations, diagnosis and management of ocular motor mononeuropathies in subjects with diabetes. Clinical manifestations often include ptosis, diplopia, and periorbital pain. Pupillary sparing is a characteristic of third nerve palsy. Differential diagnosis may be challenging due to overlapping symptoms with nerve palsies of other aetiologies. Treatment includes optimised glycaemic control and management of vascular risk factors. Neuroprotective agents, mainly alpha-lipoic acid and botulinum toxin A have been occasionally used, as well. Spontaneous recovery is seen in many cases.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Prediabetic State",
- "Incidence",
- "Middle Aged",
- "Depression",
- "Triglycerides",
- "United States",
- "Adult",
- "Blood Glucose",
- "Nutrition Surveys",
- "Diabetes Mellitus",
- "Aged",
- "Insulin Resistance"
- ]
+ "Oculomotor Nerve Diseases",
+ "Diabetic Neuropathies",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39693267",
- "Title": "Diabetes care",
- "ArticleTitle": "Glycemic Management and Individualized Diabetes Care in Dialysis-Dependent Kidney Failure.",
- "Abstract": "Of the nearly 600,000 people in the U.S. who receive dialysis for chronic kidney failure, >60% have diabetes. People receiving dialysis who have diabetes have worse overall and cardiovascular survival rates than those without diabetes. Diabetes care in the dialysis setting is complicated by kidney failure-related factors that render extrapolation of glycated hemoglobin (HbA1c) targets to the dialysis population unreliable and may change the risk-benefit profiles of glucose-lowering and disease-modifying therapies. No prospective studies have established the optimal glycemic targets in the dialysis population, and few randomized clinical trials of glucose-lowering medications included individuals receiving dialysis. Observational data suggest that both lower and higher HbA1c are associated with mortality in the dialysis population. Existing data suggest the potential for safety and effectiveness of some glucose-lowering medications in the dialysis population, but firm conclusions are hindered by limitations in study design and sample size. While population-specific knowledge gaps about optimal glycemic targets and diabetes medication safety and effectiveness preclude the extension of all general population diabetes guidelines to the dialysis-dependent diabetes population, these uncertainties should not detract from the importance of providing person-centered diabetes care to people receiving dialysis. Diabetes care for individuals with and without dialysis-dependent kidney failure should be holistic, based on individual preferences and prognoses, and tailored to integrate established treatment approaches with proven benefits for glycemic control and cardiovascular risk reduction. Additional research is needed to inform how recent pharmacologic and technological advances can be applied to support such individualized care for people receiving maintenance dialysis.",
+ "PMID": "39508279",
+ "Title": "Journal of diabetes science and technology",
+ "ArticleTitle": "Advanced Glycation End Products (AGEs) Webinar Meeting Report.",
+ "Abstract": "The advanced glycation end products (AGEs) Webinar was co-hosted by Diabetes Technology Society and Kitalys Institute on August 8, 2024, with the goal of reviewing progress made in the measurement and use of AGEs in clinical practice. Meeting topics included (1) AGEs as predictors of diabetic nephropathy (DKD), (2) hemoglobin glycation index (HGI) and the glycation gap (GG), (3) formation and structure of AGEs, (4) AGEs as a risk factor of cardiovascular disease (CVD), and (5) approaches to limit or prevent AGE formation.",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Renal Dialysis",
- "Kidney Failure, Chronic",
+ "Glycation End Products, Advanced",
+ "Cardiovascular Diseases",
+ "Diabetic Nephropathies",
"Glycated Hemoglobin",
- "Diabetes Mellitus",
- "Blood Glucose",
- "Precision Medicine",
- "Hypoglycemic Agents",
- "Glycemic Control"
- ]
+ "Biomarkers",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39692388",
- "Title": "The Israel Medical Association journal : IMAJ",
- "ArticleTitle": "Ethnic Disparities in Chronic Diseases: Comparison Between Arabs and Jews in Israel.",
- "Abstract": "Significant differences were found in the prevalence of chronic diseases among Arab and Jewish patients in Israel. Culturally relevant interventions are crucial for disease prevention, early diagnosis, and management of chronic diseases among different ethnic groups.",
+ "PMID": "39508278",
+ "Title": "Journal of diabetes science and technology",
+ "ArticleTitle": "Importance of Cybersecurity/The Relevance of Cybersecurity to Diabetes Devices: An Update from Diabetes Technology Society.",
+ "Abstract": "As medical devices become more integrated with wireless technologies, the risks of cyberattacks and data breaches increase, making stringent cybersecurity measures essential. The implementation of rigorous cybersecurity standards is essential for enhancing the cybersecurity of devices. This article examines the evolving cyber threats faced by the medical technology industry, the role of IEEE 2621 in providing comprehensive security benchmarks for medical devices, and the need for continuous risk assessments and adherence to regulatory standards to mitigate future cyber risks. Adherence to cybersecurity standards establishes ensures the effective protection of sensitive data and critical infrastructure.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Adolescent",
- "Adult",
- "Aged",
- "Female",
+ "Computer Security",
"Humans",
- "Male",
- "Middle Aged",
- "Young Adult",
- "Arabs",
- "Chronic Disease",
"Diabetes Mellitus",
- "Health Status Disparities",
- "Israel",
- "Jews",
- "Obesity",
- "Prevalence",
- "Retrospective Studies"
- ]
+ "Equipment and Supplies",
+ "Biomedical Technology",
+ "Wireless Technology"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39686708",
- "Title": "Biometrical journal. Biometrische Zeitschrift",
- "ArticleTitle": "Assessing Balance of Baseline Time-Dependent Covariates via the Fr\u00e9chet Distance.",
- "Abstract": "Assessment of covariate balance is a key step when performing comparisons between groups particularly in real-world data. We generally evaluate it on baseline covariates, but rarely on longitudinal ones prior to a management decision. We could use pointwise standardized mean differences, standardized differences of slopes, or weights from the model for such purpose. Pointwise differences could be cumbersome for densely sampled longitudinal markers and/or measured at different points. Slopes are suitable for linear or transformable models but not for more complex curves. Weights do not identify the specific covariate(s) responsible for imbalances. This work presents the Fr\u00e9chet distance as a viable alternative to assess balance of time-dependent covariates. A set of linear and nonlinear curves for which their standardized difference or differences in functional parameters were within 10% sought to identify the Fr\u00e9chet distance equivalent to this threshold. This threshold is dependent on the level of noise present and thus within group heterogeneity and error variance are needed for its interpretation. Applied to a set of real curves representing the monthly trajectory of hemoglobin A1c from diabetic patients showed that the curves in the two groups were not balanced at the 10% mark. A Beta distribution represents the Fr\u00e9chet distance distribution reasonably well in most scenarios. This assessment of covariate balance provides the following advantages: It can handle curves of different lengths, shapes, and arbitrary time points. Future work includes examining the utility of this measure under within-series missingness, within-group heterogeneity, its comparison with other approaches, and asymptotics.",
+ "PMID": "39480931",
+ "Title": "Science (New York, N.Y.)",
+ "ArticleTitle": "Britain's postwar sugar craze confirms harms of sweet diets.",
+ "Abstract": "End of sugar rationing boosted diabetes, hypertension rates.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Glycated Hemoglobin",
- "Time Factors",
- "Biometry",
- "Models, Statistical",
- "Diabetes Mellitus"
- ]
+ "Diabetes Mellitus",
+ "Dietary Sugars",
+ "Hypertension",
+ "United Kingdom",
+ "Food Insecurity",
+ "Male",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "3"
+ }
},
{
- "PMID": "39686687",
- "Title": "Alimentary pharmacology & therapeutics",
- "ArticleTitle": "Risk-Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome.",
- "Abstract": "People with diabetes or metabolic syndrome reach risk levels comparable to the average risk population three to four years earlier. Our results offer empirical guidance for defining risk-adapted starting ages of CRC screening for these high-risk groups.",
+ "PMID": "39437357",
+ "Title": "North Carolina medical journal",
+ "ArticleTitle": "\"It Takes a Village\"- A Conversation with the Interprofessional Diabetes Clinic at the ECU Health Family Medicine Center.",
+ "Abstract": "Interprofessional collaboration and shared understanding positively impact both patients and providers. Current recommendations from the CDC and experts agree that collaboration between diverse professions is necessary to improve patient outcomes and empower patients to selfmanage their chronic conditions.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Colorectal Neoplasms",
- "Metabolic Syndrome",
- "Middle Aged",
- "Early Detection of Cancer",
- "Male",
- "Europe",
- "Female",
- "Adult",
"Diabetes Mellitus",
- "North America",
- "Age Factors",
- "Risk Factors",
- "Mass Screening",
- "Risk Assessment"
- ]
+ "Interprofessional Relations",
+ "North Carolina",
+ "Patient Care Team",
+ "Cooperative Behavior",
+ "Family Practice"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "22"
+ }
},
{
- "PMID": "39684919",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "The Emerging Role of p21 in Diabetes and Related Metabolic Disorders.",
- "Abstract": "In the context of cell cycle inhibition, anti-proliferation, and the dysregulation observed in certain cancer pathologies, the protein p21 assumes a pivotal role. p21 links DNA damage responses to cellular processes such as apoptosis, senescence, and cell cycle arrest, primarily functioning as a regulator of the cell cycle. However, accumulating empirical evidence suggests that p21 is both directly and indirectly linked to a number of different metabolic processes. Intriguingly, recent investigations indicate that p21 significantly contributes to the pathogenesis of diabetes. In this review, we present a comprehensive evaluation of the scientific literature regarding the involvement of p21 in metabolic processes, diabetes etiology, pancreatic function, glucose homeostasis, and insulin resistance. Furthermore, we provide an encapsulated overview of therapies that target p21 to alleviate metabolic disorders. A deeper understanding of the complex interrelationship between p21 and diabetes holds promise for informing current and future therapeutic strategies to address this rapidly escalating health crisis.",
+ "PMID": "39427318",
+ "Title": "Cell reports",
+ "ArticleTitle": "A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes.",
+ "Abstract": "In a patient with permanent neonatal syndromic diabetes clinically similar to cases with ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of ONECUT1. Through genetic, genomic, and functional studies, we identified a crucial regulatory region acting as an enhancer of ONECUT1 specifically during pancreatic development. This enhancer region contains a low-frequency variant showing a strong association with type 2 diabetes and other glycemic traits, thus extending the contribution of this region to common forms of diabetes. Clinical relevance is provided by experimentally tailored therapy options for patients carrying ONECUT1 coding or regulatory mutations.",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Cyclin-Dependent Kinase Inhibitor p21",
+ "Pancreas",
"Diabetes Mellitus",
"Animals",
- "Metabolic Diseases",
- "Insulin Resistance",
- "DNA Damage"
- ]
+ "Diabetes Mellitus, Type 2",
+ "Enhancer Elements, Genetic",
+ "Mice",
+ "Male",
+ "Mutation",
+ "Regulatory Sequences, Nucleic Acid",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39684905",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues.",
- "Abstract": "Like humans, cats have a strong relationship between decreasing insulin sensitivity and the development of diabetes with obesity. However, the underlying molecular mechanisms of impaired insulin secretion and signaling in cats remain largely unknown. A total of 54 client-owned nondiabetic lean (",
+ "PMID": "39414473",
+ "Title": "The veterinary clinics of North America. Exotic animal practice",
+ "ArticleTitle": "Glucose Homeostasis and Derangement in Birds.",
+ "Abstract": "Birds (class Aves) have 1.5 to 2 times higher blood glucose concentrations than mammals of comparable sizes. The reasons for this have been studied and are believed to be multifactorial. There is low expression of insulin receptors, decreased sensitivity of the pancreatic \u03b2-cells to glucose, an absent or dysfunctional glucose transporter type 4 pathway, and increased blood glucagon concentrations. Glucagon and somatostatin appear to play a greater role than insulin in glucose homeostasis in birds. Severe hyperglycemia in birds can be attributed to diabetes mellitus, necessitating therapy to prevent short-term and long-term deleterious effects.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Animals",
- "Cats",
- "Insulin",
- "Signal Transduction",
- "Muscle, Skeletal",
- "Biomarkers",
- "Liver",
- "Cat Diseases",
- "Male",
- "Pancreas",
+ "Birds",
+ "Homeostasis",
+ "Bird Diseases",
+ "Blood Glucose",
"Diabetes Mellitus",
- "Receptor, Insulin",
- "Female",
- "Insulin Resistance",
- "Insulin Receptor Substrate Proteins",
- "Glucagon-Like Peptide 1",
- "Incretins"
- ]
+ "Glucose",
+ "Insulin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "17"
+ }
},
{
- "PMID": "39684868",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases.",
- "Abstract": "Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people's lives and health. To date, therapeutics with high therapeutic efficacy and low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatment. Here, we first introduce the diversity of nanomaterials and the effects of their different physicochemical properties on pancreatic function. Following this, we analyze the potential of nanomaterials to enhance pancreatic targeting by overcoming the challenges of traditional delivery methods through surface modifications, structural adjustments, and optimized drug loading. Then, we introduce the application of structurally optimized nanomaterials to pancreatic-related diseases. For instance, on pancreatic cancer (as drug delivery platforms, for the promotion of radiation therapy, and as multifunctional tools), pancreatitis (as drug delivery systems, anti-inflammatory and anti-fibrotic agents), and diabetes (as insulin delivery carriers, for protecting pancreatic \u03b2 cells, and for improving insulin resistance). Through analysis of the progress of current research, we summarize how nanomaterials can enhance treatment efficacy while minimizing side effects. Finally, we look forward to the prospects of nanomaterials in pancreatic disease treatment.",
+ "PMID": "39401393",
+ "Title": "Diabetes",
+ "ArticleTitle": "Brain Defense of Glycemia in Health and Diabetes.",
+ "Abstract": "The brain coordinates the homeostatic defense of multiple metabolic variables, including blood glucose levels, in the context of ever-changing external and internal environments. The biologically defended level of glycemia (BDLG) is the net result of brain modulation of insulin-dependent mechanisms in cooperation with the islet, and insulin-independent mechanisms through direct innervation and neuroendocrine control of glucose effector tissues. In this article, we highlight evidence from animal and human studies to develop a framework for the brain's core homeostatic functions-sensory/afferent, integration/processing, and motor/efferent-that contribute to the normal BDLG in health and its elevation in diabetes.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Nanostructures",
- "Pancreatic Diseases",
+ "Brain",
+ "Blood Glucose",
+ "Homeostasis",
"Animals",
- "Drug Delivery Systems",
- "Pancreatic Neoplasms",
"Diabetes Mellitus",
- "Drug Carriers",
- "Pancreas"
- ]
+ "Insulin",
+ "Hyperglycemia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "14"
+ }
},
{
- "PMID": "39684468",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "Multifaceted Role of Apolipoprotein C3 in Cardiovascular Disease Risk and Metabolic Disorder in Diabetes.",
- "Abstract": "Apolipoprotein C3 (APOC3) plays a critical role in regulating triglyceride levels and serves as a key predictor of cardiovascular disease (CVD) risk, particularly in patients with diabetes. While APOC3 is known to inhibit lipoprotein lipase, recent findings reveal its broader influence across lipoprotein metabolism, where it modulates the structure and function of various lipoproteins. Therefore, this review examines the complex metabolic cycle of APOC3, emphasizing the impact of APOC3-containing lipoproteins on human metabolism, particularly in patients with diabetes. Notably, APOC3 affects triglyceride-rich lipoproteins and causes structural changes in high-, very low-, intermediate-, and low-density lipoproteins, thereby increasing CVD risk. Evidence suggests that elevated APOC3 levels-above the proposed safe range of 10-15 mg/dL-correlate with clinically significant CVD outcomes. Recognizing APOC3 as a promising biomarker for CVD, this review underscores the urgent need for high-throughput, clinically feasible methods to further investigate its role in lipoprotein physiology in both animal models and human studies. Additionally, we analyze the relationship between APOC3-related genes and lipoproteins, reinforcing the value of large-population studies to understand the impact of APOC3 on metabolic diseases. Ultimately, this review supports the development of therapeutic strategies targeting APOC3 reduction as a preventive approach for diabetes-related CVD.",
+ "PMID": "39392157",
+ "Title": "Journal of biochemical and molecular toxicology",
+ "ArticleTitle": "Response to \"the Letter to the Editor by Yoshida et al., Monosodium glutamate added to food does not induce damage to the pancreas nor aggravate diabetes due to enhancement of oxidative stress\" for editorial evaluation.",
+ "Abstract": "",
"Predictions": [
- "Diabetes",
- "Cardiovascular diseases"
+ "Diabetes"
],
"MeshTerms": [
+ "Oxidative Stress",
+ "Sodium Glutamate",
+ "Pancreas",
"Humans",
- "Apolipoprotein C-III",
- "Cardiovascular Diseases",
"Animals",
- "Diabetes Mellitus",
- "Metabolic Diseases",
- "Lipoproteins",
- "Triglycerides",
- "Biomarkers"
- ]
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39684379",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "Increased Leptin Levels in Plasma and Serum in Patients with Metabolic Disorders: A Systematic Review and Meta-Analysis.",
- "Abstract": "A large number of studies have reported the relationships between leptin levels and diabetes or obesity. However, the results are still controversial, and no consensus has been reached. Therefore, the purpose of the study was to collect data from various databases to perform a meta-analysis and address the inconsistencies in these studies. A systematic literature search was conducted on PubMed, Web of Science, and EBSCO for relevant available articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association by a meta-analysis. Fifteen reports with 1,388 cases and 3,536 controls were chosen for the meta-analysis. First, an increase in leptin levels in serum (SMD 0.69; 95% CI 0.36-1.02 ng/mL) and plasma (SMD 0.46; 95% CI 0.18-0.74 ng/mL) was observed in individuals with diabetes compared to controls. This increased level was also observed by gender and population. Second, statistical analysis showed that leptin levels in serum were significantly increased in individuals with obesity (SMD 1.03; 95% CI 0.72-1.34 ng/mL). This meta-analysis analyzed leptin in individuals with diabetes or obesity and emphasized the importance of monitoring serum/plasma leptin levels in patients with these diseases. However, more comprehensive studies are necessary in order to draw firm conclusions.",
+ "PMID": "39390186",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Leptin",
"Humans",
- "Obesity",
- "Metabolic Diseases",
- "Diabetes Mellitus",
- "Female",
- "Male",
- "Biomarkers"
- ]
+ "Influenza Vaccines",
+ "Influenza, Human",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39684343",
- "Title": "International journal of molecular sciences",
- "ArticleTitle": "Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis.",
- "Abstract": "Major depressive disorder (MDD) and diabetes mellitus (DM) remain among the most prevalent diseases and the most significant challenges faced by medicine in the 21st century. The frequent co-occurrence and bidirectional relationship between the two conditions necessitates the identification of treatment strategies that benefit both. The purpose of this study was to systematically review and meta-analyze data on the efficacy and safety of agomelatine (AGO) in the treatment of patients with depression with comorbid diabetes to explore its potential mechanism of action in both diseases and its impact on diabetic parameters. Following PRISMA guidelines, a total of 11 studies were identified, both preclinical and clinical trials. Agomelatine has shown great potential as a treatment option for patients with diabetes and comorbid depression and anxiety. In addition to improving depressive and anxiety symptoms, it is also beneficial in glycemic control. A meta-analysis demonstrated a statistically significant reduction in glycated hemoglobin (HbA1C) and fasting blood glucose (FBG) levels following AGO administration over a period of 8-16 weeks. The administration of agomelatine was found to result in a significantly greater reduction in HbA1C than that observed with the selective serotonin reuptake inhibitor (SSRI) medications (namely fluoxetine, sertraline, and paroxetine) during 12-16 weeks of therapy. Furthermore, AGO has been found to be at least as effective as SSRIs in reducing depressive symptoms and more effective than SSRIs in reducing anxiety symptoms. The safety of such treatment is similar to SSRIs; no severe adverse events were reported, and the incidence of some side effects, such as insomnia and sexual dysfunction, are even less often reported. Particularly promising is also its potential action in improving some diabetic complications reported in preclinical trials. This might be through mechanisms involving the reduction in oxidative stress, anti-inflammatory effects, and potentially noradrenergic or NMDA receptor modulation. Further clinical studies on larger sample sizes, as well as elucidating its mechanisms of action, especially in the context of diabetic complications, are needed. Research should also focus on identifying the patient subpopulations most likely to benefit from agomelatine treatment.",
+ "PMID": "39377722",
+ "Title": "Anesthesiology",
+ "ArticleTitle": "Gastric Volume and Diabetes: Reply.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Acetamides",
"Diabetes Mellitus",
- "Depression",
- "Antidepressive Agents",
- "Depressive Disorder, Major",
- "Blood Glucose",
- "Glycated Hemoglobin",
- "Treatment Outcome",
- "Naphthalenes"
- ]
+ "Stomach"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
},
{
- "PMID": "39683638",
- "Title": "Nutrients",
- "ArticleTitle": "High Meat Intake and Ferritin Levels in Relation to Cardiovascular Risk Among Individuals with Diabetes in Mongolia.",
- "Abstract": "In this diabetic Mongolian population, high meat intake was associated with elevated ferritin levels, which may have reflected dietary iron intake rather than systemic inflammation or increased CVD risk.",
+ "PMID": "39377717",
+ "Title": "Anesthesiology",
+ "ArticleTitle": "Gastric Volume and Diabetes: Comment.",
+ "Abstract": "",
"Predictions": [
- "Diabetes",
- "Cardiovascular diseases"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Ferritins",
- "Male",
- "Middle Aged",
- "Female",
- "Mongolia",
- "Cross-Sectional Studies",
- "Cardiovascular Diseases",
- "Meat",
- "Diet",
- "Heart Disease Risk Factors",
- "Adult",
- "Biomarkers",
- "Aged",
+ "Stomach",
"Diabetes Mellitus",
- "Risk Factors"
- ]
+ "Organ Size"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
},
{
- "PMID": "39683480",
- "Title": "Nutrients",
- "ArticleTitle": "Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults.",
- "Abstract": "Findings of the present study indicate that the dietary intake of PUFAs was cross-sectionally, inversely, and significantly associated with blood glucose levels and the prevalence of diabetes in a large sample of Italian community-dwelling older adults.",
+ "PMID": "39373346",
+ "Title": "Journal of diabetes",
+ "ArticleTitle": "Increased prevalence of diabetes mellitus and its metabolic risk factors from 2002 to 2017 in Shanghai, China.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Aged",
- "Male",
- "Female",
- "Cross-Sectional Studies",
- "Blood Glucose",
- "Independent Living",
- "Italy",
- "Fatty Acids, Unsaturated",
+ "China",
+ "Prevalence",
+ "Risk Factors",
"Diabetes Mellitus",
- "Aged, 80 and over",
- "Diet",
- "Blood Pressure",
- "Cardiometabolic Risk Factors",
- "Fatty Acids, Omega-3",
- "Body Mass Index"
- ]
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Metabolic Syndrome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39683416",
- "Title": "Nutrients",
- "ArticleTitle": "Trends and Motivations in Dietary Supplement Use Among People with Diabetes: A Population-Based Analysis Using National Health and Nutrition Examination Survey Data from the 2009-2020 Period.",
- "Abstract": "Dietary supplement use is prevalent among people with diabetes, and most diabetic supplement use is self-directed, which reflects a growing trend toward complementary therapies. Healthcare providers are encouraged to inquire about patients' use of supplements and offer appropriate guidance as an integral component of comprehensive diabetes management.",
+ "PMID": "39368890",
+ "Title": "Oral and maxillofacial surgery clinics of North America",
+ "ArticleTitle": "The Effect of Patient-associated Factors on Long-Term Survival of Dental Implants.",
+ "Abstract": "Dental implant therapy has developed over the past half century to have documented successful outcomes in most patients who receive treatment. The long-term survival of dental implants depends upon a variety of factors including patient, surgeon, restorative dentist, and materials-related factors. The impact of patient-associated factors may impact significantly on the success of dental implants including diabetes mellitus, medications, smoking, parafunctional habits, oral hygiene, head and neck radiation, and the use of bisphosphonates, antiangiogenic, and antiresorptive medications.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Dietary Supplements",
- "Female",
- "Nutrition Surveys",
- "Male",
- "Middle Aged",
- "Adult",
- "United States",
+ "Dental Implantation, Endosseous",
+ "Dental Implants",
+ "Dental Restoration Failure",
"Diabetes Mellitus",
- "Motivation",
- "Aged",
- "Young Adult"
- ]
+ "Oral Hygiene",
+ "Risk Factors",
+ "Smoking"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39681993",
- "Title": "Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association",
- "ArticleTitle": "Hepatic parenchymal hypoattenuation in dogs with diabetes mellitus on computed tomography consistent with hepatic steatosis.",
- "Abstract": "Hypoattenuation of the liver, consistent with hepatic steatosis or lipidosis, has been reported in veterinary patients. In people, measuring CT hepatic attenuation is diagnostic for hepatic steatosis, and hypoattenuation of the liver is defined as absolute if less than 40\u00a0HU or relative if the liver is 10\u00a0HU less than the spleen. The purpose of this study is to describe hepatic parenchymal attenuation in dogs with diabetes mellitus with or without diabetic ketosis (DK) or diabetic ketoacidosis (DKA), using the above categorization for absolute and relative hypoattenuation, as with humans. We hypothesized dogs with DK or DKA were more likely to have hypoattenuating livers. Twenty-seven diabetic dogs were included; fifteen were categorized in Group 1 as without DK or DKA, six in Group 2 as DK, and six in Group 3 as DKA. In Group 3, four of six dogs had absolute and relative hypoattenuating livers. Three of these were visually hypoattenuating to the vasculature, with one having negative attenuation and a histopathologic diagnosis of severe hepatic lipidosis. In Group 2, four of six dogs had relative hypoattenuating livers. In Group 1, only one of 15 dogs had a relatively hypoattenuating liver. Groups 2 and 3 had significantly lower absolute liver attenuation than Group 1. Presumed hepatic steatosis was present on CT and was more common with DK or DKA. These findings may help provide hepatic sampling recommendations and alter patient prognosis. Further research is needed to establish absolute and relative liver attenuation in dogs with correlation to histopathology and patient outcome.",
+ "PMID": "39368822",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Diabetes, loved ones: Constraints, support, shared experiences].",
+ "Abstract": "Diabetes is a pathology that has major consequences not only for those who suffer from it, but also for those around them. Relatives can play different roles in this respect, depending on the type of relationship they have with the person with diabetes. The onset of the disease is likely to modify pre-established roles within social groups such as the family sphere, with the possibility of strengthening ties, but also of damaging them.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Animals",
- "Dogs",
- "Dog Diseases",
- "Fatty Liver",
- "Tomography, X-Ray Computed",
- "Male",
- "Liver",
- "Female",
- "Diabetic Ketoacidosis",
+ "Humans",
+ "Social Support",
"Diabetes Mellitus",
- "Retrospective Studies"
- ]
+ "Family",
+ "Caregivers"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39681831",
- "Title": "Cardiovascular & hematological disorders drug targets",
- "ArticleTitle": "A Comprehensive Review of Fear of Eating Behaviour in Individuals with Diabetes: Exploring Therapeutic Interventions for Diabulimia.",
- "Abstract": "A multidisciplinary strategy combining healthcare specialists specializing in diabetes management, mental health, and nutrition is required for effective therapy of fear of eating behaviour in diabetes. Cognitive-behavioral therapy and mindfulness-based therapies, as well as psychological support, have shown potential in reducing the fear of eating habits. This analysis gives significant information for healthcare providers to help patients with diabetes who are afraid of eating and urges additional research on the topic.",
+ "PMID": "39368819",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Physical activity and diabetes: Where, when, how and with whom?].",
+ "Abstract": "Today, physical activity is one of the most effective preventive and health-promoting factors for people with diabetes. Understanding the issues involved and how to implement it will help you to support patients in maintaining this practice.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Fear",
- "Feeding Behavior",
+ "Exercise",
"Diabetes Mellitus",
- "Cognitive Behavioral Therapy",
- "Feeding and Eating Disorders"
- ]
+ "Health Promotion"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39681614",
- "Title": "Scientific reports",
- "ArticleTitle": "Nerve ultrasound helps to distinguish CIDP patients with diabetes from patients with diabetic polyneuropathy.",
- "Abstract": "Diabetic polyneuropathy (DPN) shares overlapping clinical and electrodiagnostic features with chronic inflammatory demyelinating polyneuropathy (CIDP), which complicates the differential diagnosis of CIDP in diabetic patients. 32 patients with diabetes mellitus and CIDP, 68 patients with CIDP without diabetes, 83 patients with DPN, and 28 diabetic patients without polyneuropathy were examined using clinical scores (Overall Neuropathy Limitation Scale (ONLS), Neuropathy Symptom Score, Neuropathy Deficit Score), nerve conduction studies, and nerve ultrasound (Ultrasound Pattern Sum Score (UPSS)). The ONLS was significantly higher in the CIDP patients with diabetes than in DPN (median [interquartile range]: 4.0 [3.0] vs. 0 [1.0], p\u2009<\u20090.001) as well as the UPSS (4.0 [6.0] vs. 0 [2.9], p\u2009<\u20090.001). Multiple binary logistic regression revealed UPSS and ONLS as statistically significant predictors to differentiate between CIDP with diabetes and DPN. Receiver operating characteristic curve analysis showed the ONLS with an area under the curve (AUC) of 0.918 (95% CI: 0.868-0.0.967, p\u2009<\u20090.001). The UPSS total score had an AUC of 0.826 (95% CI: 0.743-0.909, p\u2009<\u20090.001). An UPSS\u2009\u2265\u20092.5 had a sensitivity of 77.4% and a specificity of 68.7% to detect CIDP. An ONLS\u2009\u2265\u20091.5 had a sensitivity of 87.1% and a specificity of 81.9% to detect CIDP. ROC curve analysis of a composite score of ONLS and UPSS revealed an AUC of 0.959 (95% CI: 0.928-0.991, p\u2009<\u20090.001). CIDP is an important differential diagnosis in people with diabetes mellitus. This study reports that the UPSS is well suited to differentiate between DPN and CIDP.",
+ "PMID": "39368818",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Diet and diabetes: constantly evolving recommendations].",
+ "Abstract": "Diabetes management has evolved into a person-centered practice, where specific needs play a central role. Different types of diabetes have different dietary characteristics, depending on the patient's profile. With better access to information, patients are keen to adopt new diets. The needs expressed by each individual must be accommodated, in order to respect their autonomy and improve their quality of life.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Polyradiculoneuropathy, Chronic Inflammatory Demyelinating",
- "Male",
- "Diabetic Neuropathies",
- "Female",
- "Middle Aged",
- "Ultrasonography",
- "Diagnosis, Differential",
- "Aged",
- "Neural Conduction",
- "ROC Curve",
- "Diabetes Mellitus"
- ]
+ "Diabetes Mellitus",
+ "Diet, Diabetic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39681186",
- "Title": "Preventive medicine",
- "ArticleTitle": "Trends in modifiable risk factors for dementia among midlife adults in the United States: The National Health and nutrition examination survey 1999-2018.",
- "Abstract": "The prevalence of diabetes and obesity increased in this large, nationally representative U.S. study population, while the prevalence of smoking decreased. More effective public health interventions are needed to mitigate the impact of these risk factors and ultimately reduce the burden of dementia in aging populations.",
+ "PMID": "39368814",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The lived experience of illness: key concepts in diabetes].",
+ "Abstract": "Understanding the lived experience of the disease enables caregivers to offer people living with diabetes personalized support tailored to their needs. The discipline of nursing also enables them to draw on reference authors to guide their thinking and professional practice. Through the concepts of transition, integration of self-care, diabetes distress and empowerment, we explore certain aspects of living with diabetes.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Middle Aged",
- "Male",
- "Female",
- "Risk Factors",
- "Nutrition Surveys",
- "United States",
- "Dementia",
- "Adult",
- "Prevalence",
- "Diabetes Mellitus",
- "Obesity",
- "Smoking",
- "Hypertension",
- "Alcohol Drinking"
- ]
+ "Self Care",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39680279",
- "Title": "Lifetime data analysis",
- "ArticleTitle": "Proportional rates model for recurrent event data with intermittent gaps and a terminal event.",
- "Abstract": "Recurrent events are common in medical practice or epidemiologic studies when each subject experiences a particular event repeatedly over time. In some long-term observations of recurrent events, a terminal event such as death may exist in recurrent event data. Meanwhile, some inspected subjects will withdraw from a study for some time for various reasons and then resume, which may happen more than once. The period between the subject leaving and returning to the study is called an intermittent gap. One naive method typically ignores gaps and treats the events as usual recurrent events, which could result in misleading estimation results. In this article, we consider a semiparametric proportional rates model for recurrent event data with intermittent gaps and a terminal event. An estimation procedure is developed for the model parameters, and the asymptotic properties of the resulting estimators are established. Simulation studies demonstrate that the proposed estimators perform satisfactorily compared to the naive method that ignores gaps. A diabetes study further shows the utility of the proposed method.",
+ "PMID": "39359412",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Editorial: Interdisciplinary research in diabetology.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Recurrence",
- "Computer Simulation",
- "Models, Statistical",
- "Proportional Hazards Models",
- "Diabetes Mellitus"
- ]
+ "Interdisciplinary Research",
+ "Diabetes Mellitus",
+ "Endocrinology"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39680083",
- "Title": "International orthopaedics",
- "ArticleTitle": "Hydrodilatation: a comparison between diabetics and non-diabetics with adhesive capsulitis.",
- "Abstract": "Hydrodilatation is an effective treatment option in the short and medium term in both diabetics and non-diabetics with adhesive capsulitis, with good relief of pain and improvement in shoulder range of motion. Diabetic patients have significantly less improvement in range of motion and pain compared to non-diabetics at six months post hydrodilatation.",
+ "PMID": "39357523",
+ "Title": "Cell metabolism",
+ "ArticleTitle": "HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.",
+ "Abstract": "HumanIslets.com supports diabetes research by offering easy access to islet phenotyping data, analysis tools, and data download. It includes molecular omics, islet and cellular function assays, tissue processing metadata, and phenotypes from 547 donors. As it expands, the resource aims to improve human islet data quality, usability, and accessibility.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Bursitis",
- "Male",
- "Female",
- "Retrospective Studies",
- "Middle Aged",
- "Aged",
- "Dilatation",
- "Range of Motion, Articular",
- "Shoulder Joint",
- "Treatment Outcome",
- "Pain Measurement",
- "Adult",
+ "Islets of Langerhans",
"Diabetes Mellitus",
- "Diabetes Complications"
- ]
+ "Phenotype",
+ "Databases, Factual"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39678201",
- "Title": "Annals of global health",
- "ArticleTitle": "Association between Food Insecurity, Socioeconomic Status of the Household Head, and Hypertension and Diabetes in Maputo City.",
- "Abstract": {
- "i": "Conclusions:"
- },
+ "PMID": "39353663",
+ "Title": "Cleveland Clinic journal of medicine",
+ "ArticleTitle": "Continuous glucose monitoring: High-tech devices still need some low-tech backup.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Hypertension",
- "Food Insecurity",
- "Male",
- "Cross-Sectional Studies",
- "Female",
- "Middle Aged",
- "Diabetes Mellitus",
- "Adult",
- "Social Class",
- "Family Characteristics",
- "Aged",
- "Risk Factors"
- ]
+ "Blood Glucose",
+ "Blood Glucose Self-Monitoring",
+ "Continuous Glucose Monitoring",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39676179",
- "Title": "The Journal of the Association of Physicians of India",
- "ArticleTitle": "Empowering Physicians for Holistic Wellness in Diabetes Management through Mind-Body Medicine: Implications of the Psycho-Neuro-Immuno-Endocrine/Enteric Concept in Diabetes.",
- "Abstract": "The psycho-neuro-immuno-endocrine/enteric (PNIE) axis is a fundamental concept in neuroscience, integral to the neuroendocrine system (NES). It encompasses the interactions between behavior, neurology, endocrinology, gut biology, and the immune system. These interactions regulate crucial metabolic processes like glucose, lipid, and protein metabolism, blood pressure, and various homeostatic functions, including blood pressure regulation, thermogenesis and pulmonary hypoxia detection.",
+ "PMID": "39347969",
+ "Title": "Journal of managed care & specialty pharmacy",
+ "ArticleTitle": "Innovation is the driver behind quality improvements in diabetes care delivery.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Holistic Health",
- "Mind-Body Therapies",
+ "Quality Improvement",
"Diabetes Mellitus",
- "Neurosecretory Systems"
- ]
+ "Delivery of Health Care"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "30"
+ }
},
{
- "PMID": "39675484",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes.",
- "Abstract": "Our research indicates that among US adults with diabetes or prediabetes, BRI exhibits a U-shaped relationship with all-cause and cardiovascular mortality, with threshold values of 5.54 and 5.21, respectively.",
+ "PMID": "39315869",
+ "Title": "NEJM evidence",
+ "ArticleTitle": "Getting Diabetes Technologies into the Hands of Those Who Need Them Most.",
+ "Abstract": "",
"Predictions": [
- "Diabetes",
- "Cardiovascular diseases"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Prediabetic State",
- "Male",
- "Female",
- "Cardiovascular Diseases",
- "Middle Aged",
- "Diabetes Mellitus",
- "Nutrition Surveys",
- "Adult",
- "Aged",
- "Body Mass Index",
- "Cause of Death",
- "Risk Factors"
- ]
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39674445",
- "Title": "Chemico-biological interactions",
- "ArticleTitle": "Host-microbiota interplay in arsenic metabolism: Implications on host glucose homeostasis.",
- "Abstract": "Arsenic (As), a naturally occurring element with unique properties, has been recognized as the largest mass poisoning in the world by the World Health Organization (WHO). Approximately 200 million people worldwide are exposed to toxic levels of arsenic due to natural and anthropogenic activities. This widespread exposure necessitates a deeper understanding of microbe-arsenic interactions and their potential influence on host exposure and health risks. It is a major causative factor for metabolic diseases, including diabetes. Arsenic exposure has been linked to dysfunction in various cell types and tissues, notably affecting pancreatic islet cells. Numerous mechanisms have been identified to be responsible for arsenic exposure under both in vitro and in vivo conditions. These mechanisms contribute to the regulation of processes underlying diabetes etiology, such as glucose-stimulated insulin secretion from pancreatic beta cells. Unlike other toxic elements, arsenic undergoes metabolism by living organisms, including microbes, plants, and animals. Other toxic elements like Lead (Pb) and mercury (Hg) are generally not metabolized in the same way as Arsenic in microbes, plants and animals. In this review, we strive to initiate a dialogue by reviewing known aspects of microbe-arsenic interactions and placing it in the context of the potential for influencing host exposure and health risks. This review provides an up-to-date insight into arsenic metabolism by the human body and its associated microbiota, as well as the deciphered molecular pathways linking the different species of arsenic in the etiology of diabetes. Additionally, the future perspectives of mitigation and detoxification of arsenic in translational medicine and limitations in current scenarios are discussed. The comprehensive review presented here underscores the importance of exploring the complex interplay between arsenic metabolism, host-microbiota interactions, and their implications on glucose homeostasis and metabolic diseases. It emphasizes the need for continued research to develop effective strategies for mitigating arsenic-related health risks and fostering better translational medicine approaches.",
+ "PMID": "39303090",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Comment on Stone et al. Atypical Diabetes: What Have We Learned and What Does the Future Hold? Diabetes Care 2024;47:770-781.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Arsenic",
- "Homeostasis",
- "Animals",
- "Glucose",
- "Diabetes Mellitus",
- "Microbiota",
- "Gastrointestinal Microbiome"
- ]
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "20"
+ }
},
{
- "PMID": "39673957",
- "Title": "Biosensors & bioelectronics",
- "ArticleTitle": "Highly sensitive and real-time detection of acetone biomarker for diabetes using a ZnO-coated optical fiber sensor.",
- "Abstract": "This work presents a ZnO-coated no-core optical fiber sensor (OFS) designed for the highly sensitive detection of acetone vapor. Acetone is a key biomarker for diabetes, which is linked to blood glucose levels and can be detected non-invasively through breath analysis. The OFS utilizes a no-core fiber (NCF) as the sensing region, coated with a thin layer of ZnO nanoparticles to enhance evanescent field interaction with the VOCs at the fiber interface. The NCF segment, optimized to 3.4\u00a0cm, maximizes coupling efficiency through multi-mode interference (MMI). The OFS was tested with six different VOCs including acetone, methanol, ethanol, isopropanol, toluene and xylene at concentrations ranging from 1 to 10\u00a0ppm, as they are commonly exhaled VOCs associated with diabetes. The fabricated OFS demonstrated high sensitivity to acetone (0.116\u00a0nm/ppm) and excellent selectivity compared to other VOCs. It exhibited a lower detection limit of 3.26\u00a0ppm, rapid response (26\u00a0s), and recovery times (32\u00a0s) for acetone, with minimal drift (0.2%) over 30 days. Operated at room temperature, this ZnO-coated no-core OFS offers a cost-effective and simple fabrication approach, showing promising potential for non-invasive acetone monitoring in diabetes.",
+ "PMID": "39303086",
+ "Title": "Diabetes",
+ "ArticleTitle": "The Sensory Neuron-Mast Cell Axis Regulation of Skin Microcirculation in Diabetes: Implication for Diabetes-Related Cutaneous Complications.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Acetone",
- "Zinc Oxide",
- "Biosensing Techniques",
"Humans",
- "Optical Fibers",
+ "Microcirculation",
+ "Skin",
+ "Sensory Receptor Cells",
"Diabetes Mellitus",
- "Biomarkers",
- "Limit of Detection",
- "Breath Tests",
- "Equipment Design",
- "Volatile Organic Compounds",
- "Fiber Optic Technology"
- ]
+ "Animals",
+ "Diabetes Complications"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "20"
+ }
},
{
- "PMID": "39673919",
- "Title": "Cancer epidemiology",
- "ArticleTitle": "Co-occurrence of cancer and diabetes in a high-income country: Age-period-cohort projections 2020-2044.",
- "Abstract": "Our findings reinforce the fact that diabetes prevention activities are also cancer prevention activities, and must therefore be prioritised and resourced in tandem. The projected volume of diabetes and cancer co-occurrence also has important policy implications in terms of workforce development, as well as service delivery.",
+ "PMID": "39293394",
+ "Title": "Cell reports. Medicine",
+ "ArticleTitle": "Decoding the diabetic bone paradox: How AGEs sabotage skeletal integrity.",
+ "Abstract": "Diabetes patients often suffer from fractures despite normal or high bone mineral density, a phenomenon known as the diabetic bone paradox. Gao et\u00a0al. identify AGEs as disrupting bone quality and compromising skeletal integrity in diabetic bone disease.",
"Predictions": [
- "Diabetes",
- "Cancer"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Neoplasms",
- "Female",
- "Male",
- "Middle Aged",
- "Incidence",
- "Adult",
- "Aged",
- "Diabetes Mellitus",
- "New Zealand",
- "Young Adult",
- "Registries",
- "Cohort Studies",
- "Adolescent",
- "Aged, 80 and over",
- "Child"
- ]
+ "Bone and Bones",
+ "Glycation End Products, Advanced",
+ "Bone Density",
+ "Animals",
+ "Fractures, Bone",
+ "Diabetes Complications",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "19"
+ }
},
{
- "PMID": "39673498",
- "Title": "Family practice",
- "ArticleTitle": "The relationship between self-care preparedness and quality of life in a 3-year-follow-up: a study in primary health care.",
- "Abstract": "Those patients who managed to increase their SCPI over the study period experienced an improvement in HRQoL.",
+ "PMID": "39292838",
+ "Title": "American journal of therapeutics",
+ "ArticleTitle": "Efficacy and Safety of Basal Insulin Fc versus Degludec Insulin: A Meta-Analysis of Randomized Controlled Trials.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Quality of Life",
- "Male",
- "Female",
- "Self Care",
- "Primary Health Care",
- "Middle Aged",
- "Aged",
- "Follow-Up Studies",
- "Longitudinal Studies",
- "Hypertension",
- "Coronary Artery Disease",
- "Diabetes Mellitus",
- "Adult",
- "Surveys and Questionnaires"
- ]
+ "Blood Glucose",
+ "Glycated Hemoglobin",
+ "Hypoglycemic Agents",
+ "Insulin, Long-Acting",
+ "Randomized Controlled Trials as Topic",
+ "Treatment Outcome",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "18"
+ }
},
{
- "PMID": "39672014",
- "Title": "Computers in biology and medicine",
- "ArticleTitle": "Exploring diabetes through the lens of AI and computer vision: Methods and future prospects.",
- "Abstract": "Early diagnosis and timely initiation of treatment plans for diabetes are crucial for ensuring individuals' well-being. Emerging technologies like artificial intelligence (AI) and computer vision are highly regarded for their ability to enhance the accessibility of large datasets for dynamic training and deliver efficient real-time intelligent technologies and predictable models. The application of AI and computer vision techniques to enhance the analysis of clinical data is referred to as eHealth solutions that employ advanced approaches to aid medical applications. This study examines several advancements and applications of machine learning, deep learning, and machine vision in global perception, with a focus on sustainability. This article discusses the significance of utilizing artificial intelligence and computer vision to detect diabetes, as it has the potential to significantly mitigate harm to human life. This paper provides several comments addressing challenges and recommendations for the use of this technology in the field of diabetes. This study explores the potential of employing Industry 4.0 technologies, including machine learning, deep learning, and computer vision robotics, as effective tools for effectively dealing with diabetes related aspects.",
+ "PMID": "39291509",
+ "Title": "The Journal of the Association of Physicians of India",
+ "ArticleTitle": "Digitalization of Diabetes Care: Clinical Relevance and Application.",
+ "Abstract": "Over the years, technological innovations have reshaped our approach toward treating chronic conditions such as diabetes. As you are aware, diabetes is a metabolic disorder requiring lifestyle changes and a lifetime of treatment and continued care. Recently, digital technology has been found to support chronic diabetes care. This editorial embarks on the evolution of digital interventions in diabetes care, tracing its trajectory from simple mobile phone messaging to the conceptualization of mobile applications.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus",
- "Artificial Intelligence",
- "Machine Learning",
- "Deep Learning",
- "Telemedicine"
- ]
+ "Mobile Applications",
+ "Telemedicine",
+ "Clinical Relevance"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "18"
+ }
},
{
- "PMID": "39671511",
- "Title": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
- "ArticleTitle": "Associations of nonoccupational sedentary behaviors with cardiometabolic outcomes: coronary artery risk development in young adults (CARDIA).",
- "Abstract": "When comparing total-SB and the 6 context-specific SBs, TV-SB was most robustly associated with HTN. The findings were less clear for DM. Behavior change strategies that target TV-SB reduction may be effective at reducing HTN risk in middle-aged adults.",
+ "PMID": "39284082",
+ "Title": "WMJ : official publication of the State Medical Society of Wisconsin",
+ "ArticleTitle": "Promoting the Effectiveness of Low-Carbohydrate/ Time-Restricted Diets in the Management of Diabetes.",
+ "Abstract": "",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Sedentary Behavior",
- "Male",
- "Female",
- "Cross-Sectional Studies",
- "Hypertension",
- "Middle Aged",
- "Adult",
+ "Diet, Carbohydrate-Restricted",
+ "Diabetes Mellitus, Type 2",
"Diabetes Mellitus",
- "Exercise",
- "Coronary Artery Disease",
- "Prospective Studies",
- "Young Adult",
- "Cardiometabolic Risk Factors",
- "Prevalence"
- ]
+ "Wisconsin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "17"
+ }
},
{
- "PMID": "39671417",
- "Title": "Puerto Rico health sciences journal",
- "ArticleTitle": "Are Patients who are Diagnosed with Hypertension or Diabetes more likely to Receive the COVID-19 Booster? Data from PR-CEAL's Community Survey Tool.",
- "Abstract": "Insights from this study can inform future vaccination campaigns through improved awareness and prevention strategies by targeting vulnerable populations in Puerto Rico.",
+ "PMID": "39279001",
+ "Title": "Obesity surgery",
+ "ArticleTitle": "Immunometabolism in Endocrine Disorders Leads to a High Frequency of Diabetes Mellitus Caused by Heteroplasmic mtDNA Mutations.",
+ "Abstract": "",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Hypertension",
- "Female",
- "Male",
- "COVID-19",
- "Adult",
+ "DNA, Mitochondrial",
+ "Mutation",
"Diabetes Mellitus",
- "Middle Aged",
- "Puerto Rico",
- "COVID-19 Vaccines",
- "Aged",
- "Surveys and Questionnaires",
- "Young Adult"
- ]
+ "Endocrine System Diseases",
+ "Mitochondrial Diseases",
+ "Heteroplasmy",
+ "Diabetes Mellitus, Type 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "16"
+ }
},
{
- "PMID": "39670874",
- "Title": "Hepatology communications",
- "ArticleTitle": "Pain in chronic liver disease compared to other chronic conditions: Results from a contemporary nationally representative cohort study.",
- "Abstract": "Liver disease independently increases the likelihood of experiencing widespread and debilitating pain. Clinicians should consider liver disease a painful condition, ensuring that they are frequently assessing and appropriately treating pain in all liver disease patients.",
+ "PMID": "39276032",
+ "Title": "Endocrinology",
+ "ArticleTitle": "Ex-CyT-ing Applications of Single-cell CyTOF to Human Pancreatic Islets in Diabetes Research.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Adult",
- "Liver Diseases",
- "Aged",
- "Analgesics, Opioid",
- "United States",
- "Liver Cirrhosis",
- "Chronic Disease",
- "Cohort Studies",
- "Liver Neoplasms",
+ "Islets of Langerhans",
+ "Single-Cell Analysis",
"Diabetes Mellitus",
- "Logistic Models",
- "Arthritis",
- "Health Surveys",
- "Chronic Pain",
- "Hepatitis, Viral, Human",
- "Renal Insufficiency, Chronic",
- "Severity of Illness Index"
- ]
+ "Insulin-Secreting Cells"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "14"
+ }
},
{
- "PMID": "39670442",
- "Title": "Expert opinion on therapeutic targets",
- "ArticleTitle": "Lipocalin-2 as a therapeutic target for diabetes neurological complications.",
- "Abstract": "To fully grasp the impact of LCN2 on neurological health, it is essential to understand its multifaceted role in metabolic regulation. Because effective LCN2-targeting drugs must penetrate the blood - brain barrier, various strategies are being developed to meet this requirement. Such therapeutics could treat various neurological complications, including diabetic encephalopathy, retinopathy, and peripheral neuropathy. While animal models offer insights into pathophysiology and potential treatments, their limitations must be acknowledged. Therefore, future research should bridge the gaps between animal findings, human studies, and clinical applications. Moreover, comprehensive personalized approaches, including LCN2-targeting drugs, lifestyle changes, and regularly monitoring individual patients, may be required to manage diabetic complications.",
+ "PMID": "39273474",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Novel Molecules in Diabetes Mellitus, Dyslipidemia and Cardiovascular Disease 2.0.",
+ "Abstract": "Diabetes mellitus, dyslipidemia and cardiovascular disorders represent very prevalent chronic diseases in developed countries contributing to a high morbidity and loss of quality of life [...].",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Animals",
- "Lipocalin-2",
- "Diabetic Neuropathies",
- "Oxidative Stress",
- "Molecular Targeted Therapy",
- "Quality of Life",
- "Cognitive Dysfunction",
- "Drug Development",
- "Blood-Brain Barrier",
+ "Dyslipidemias",
+ "Cardiovascular Diseases",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "14"
+ }
},
{
- "PMID": "39670363",
- "Title": "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing",
- "ArticleTitle": "LLM-CGM: A Benchmark for Large Language Model-Enabled Querying of Continuous Glucose Monitoring Data for Conversational Diabetes Management.",
- "Abstract": "Over the past decade, wearable technology has dramatically changed how patients manage chronic diseases. The widespread availability of on-body sensors, such as heart rate monitors and continuous glucose monitoring (CGM) sensors, has allowed patients to have real-time data about their health. Most of these data are readily available on patients' smartphone applications, where patients can view their current and retrospective data. For patients with diabetes, CGM has transformed how their disease is managed. Many sensor devices interface with smartphones to display charts, metrics, and alerts. However, these metrics and plots may be challenging for some patients to interpret. In this work, we explore how large language models (LLMs) can be used to answer questions about CGM data. We produce an open-source benchmark of time-series question-answering tasks for CGM data in diabetes management. We evaluate different LLM frameworks to provide a performance benchmark. Lastly, we highlight the need for more research on how to optimize LLM frameworks to best handle questions about wearable data. Our benchmark is publicly available for future use and development. While this benchmark is specifically designed for diabetes care, our model implementation and several of the statistical tasks can be extended to other wearable device domains.",
+ "PMID": "39265998",
+ "Title": "Journal of insurance medicine (New York, N.Y.)",
+ "ArticleTitle": "The Long-term Complications of Covid-19 Infection.",
+ "Abstract": "As the Covid-19 pandemic continues into its 4th year, reports of long-term morbidity and mortality are now attracting attention. Recent studies suggest that Covid-19 survivors are at increased risk of common illnesses, such as myocardial infarction, diabetes mellitus and autoimmune disorders. Mortality may also be increased. This article will review the evidence that supports some of these observations and provide an opinion about their validity and their relevance to insured cohorts.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Blood Glucose Self-Monitoring",
- "Computational Biology",
+ "Autoimmune Diseases",
+ "COVID-19",
"Diabetes Mellitus",
- "Benchmarking",
- "Blood Glucose",
- "Wearable Electronic Devices",
- "Smartphone",
- "Mobile Applications",
- "Language",
- "Continuous Glucose Monitoring"
- ]
+ "Myocardial Infarction",
+ "Pandemics",
+ "SARS-CoV-2",
+ "Survivors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "13"
+ }
},
{
- "PMID": "39667764",
- "Title": "Zhonghua yi xue za zhi",
- "ArticleTitle": "[The value of local antibiotics for foot infection in persons with diabetes].",
- "Abstract": "Diabetes-related foot infections(DFI), including diabetes-related foot osteomyelitis, are generally treated with systemic antibiotics. However, systemic antibiotics are often overused and administered for excessively long periods, making patients more susceptible to multidrug-resistant bacteria. Local antibiotics may be beneficial to DFI patients. This article reviews the advantages and disadvantages, types and clinical evidence of local antibiotics in the treatment of DFI, and points out the research gaps and future research direction in this field. This article aims to provide a reference for clinicians in formulating anti-infectious treatment plans for DFI.",
+ "PMID": "39250449",
+ "Title": "British journal of nursing (Mark Allen Publishing)",
+ "ArticleTitle": "The fundamentals of diabetes care.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Anti-Bacterial Agents",
- "Diabetic Foot",
- "Osteomyelitis",
"Diabetes Mellitus",
- "Anti-Infective Agents, Local"
- ]
+ "United Kingdom"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "9"
+ }
},
{
- "PMID": "39666834",
- "Title": "Annals of the New York Academy of Sciences",
- "ArticleTitle": "Diabetes and cardiovascular disease in older adults.",
- "Abstract": "An aging population combined with a rapidly increasing prevalence of diabetes foreshadows a global epidemic of cardiovascular and kidney disease that threatens to halt improvements in life and health-span and will have particularly severe consequences in older adults. The management of diabetes has been transformed with the recent development of newer anti-hyperglycemic agents that have demonstrated superior efficacy. However, the utility of these drugs extends beyond glycemic control to benefits for managing obesity, cardiovascular disease (CVD), chronic kidney disease, and heart failure. Numerous cardiovascular and kidney outcomes trials of these drugs have played an instrumental role in shaping current guidelines for the management of diabetes and CVD. Older adults with diabetes are diverse in terms of their comorbidities, diabetic complications, and cognitive and functional status. Therefore, there is an unmet need for personalized management of diabetes and CVD in this population. In this review, we provide an overview of the epidemiological burden and management of diabetes and CVD in older adults. We then focus on randomized cardiovascular and kidney outcome trials with anti-hyperglycemic agents to propose an evidence-based approach to the management of diabetes in older adults with high risk of cardiovascular and kidney disease.",
+ "PMID": "39242135",
+ "Title": "American heart journal",
+ "ArticleTitle": "Response to Tomoyuki Kawada: Blood and urine metal levels in patients with diabetes and cardiovascular disease.",
+ "Abstract": "",
"Predictions": [
"Diabetes",
- "Cardiovascular diseases",
- "Diabetes type 2"
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
"Cardiovascular Diseases",
- "Aged",
- "Hypoglycemic Agents",
- "Diabetes Mellitus, Type 2",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "7"
+ }
},
{
- "PMID": "39666732",
- "Title": "PloS one",
- "ArticleTitle": "SHINE study: Developing an intervention for safe hospital insulin use for older or frail adults with diabetes undergoing surgical hospital admission: Study protocol.",
- "Abstract": "This article outlines the methodology for the planned study which will employ a novel methodology to tackle the problem of hospital insulin safety. Its findings will contribute to a better understanding of the multiple interacting components implicated in hospital insulin use (patient, staff, context) and support further work around system-based strategies to enhance insulin safety resilience in hospital.",
+ "PMID": "39242134",
+ "Title": "American heart journal",
+ "ArticleTitle": "Blood and urine metal levels in patients with diabetes and cardiovascular disease.",
+ "Abstract": "",
"Predictions": [
- "Diabetes"
+ "Diabetes",
+ "Cardiovascular diseases"
],
"MeshTerms": [
"Humans",
- "Insulin",
- "Aged",
- "Diabetes Mellitus",
- "Hospitalization",
- "Frail Elderly",
- "Hypoglycemic Agents",
- "Female",
+ "Cardiovascular Diseases",
"Male",
- "Hospitals"
- ]
+ "Female",
+ "Diabetes Mellitus",
+ "Middle Aged",
+ "Aged",
+ "Cadmium"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "7"
+ }
},
{
- "PMID": "39666445",
- "Title": "ACS biomaterials science & engineering",
- "ArticleTitle": "Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration.",
- "Abstract": "The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede bone regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system in the diabetic microenvironment will result in a high rate of impaired, delayed, or even nonhealing events of bone tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems to treat diabetic bone defects via the combination of microenvironmental regulation and enhanced osteogenic capacity. Following the natural bone healing processes, coupling of angiogenesis and osteogenesis by advanced bioresponsive drug delivery systems has proved to be of significant approach for promoting bone repair in DM. In this Review, we have systematically summarized the mechanisms and therapeutic strategies of DM-induced impaired bone healing, outlined the bioresponsive design for drug delivery systems, and highlighted the vascularization strategies for promoting bone regeneration. Accordingly, we then overview the recent advances in developing bioresponsive drug delivery systems to facilitate diabetic vascularized bone regeneration by remodeling the microenvironment and modulating multiple regenerative cues. Furthermore, we discuss the development of adaptable drug delivery systems with unique features for guiding DM-associated bone regeneration in the future.",
+ "PMID": "39240676",
+ "Title": "Journal of cardiopulmonary rehabilitation and prevention",
+ "ArticleTitle": "Cardiac Rehabilitation: Importance of Blood Glucose Control Among Patients with Diabetes Post Acute Myocardial Infarction.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
- "Bone Regeneration",
"Humans",
- "Drug Delivery Systems",
- "Animals",
- "Diabetes Mellitus",
- "Neovascularization, Physiologic",
- "Osteogenesis",
- "Biocompatible Materials"
- ]
+ "Myocardial Infarction",
+ "Cardiac Rehabilitation",
+ "Blood Glucose",
+ "Glycemic Control",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "6"
+ }
},
{
- "PMID": "39666416",
- "Title": "Medicina",
- "ArticleTitle": "[Advances in continuous glucose monitoring: evidence of a new generation technology].",
- "Abstract": "Continuous glucose monitoring (CGM) provides comprehensive and dynamic information to guide the management of diabetes mellitus (DM). This paper summarizes the evidence and implications of the use of the new CGM system, FreeStyle Libre 2 (FSL2). A global review of the literature on the use of FSL2 in people with DM was performed. All types of studies were included. The evidence is presented qualitatively together with expert clinical opinion. FSL2 is an integrated CGM system with real-time glucose readings (no scanning required) and customizable alarms. In studies of subjects aged 2 years and older with DM1 or DM2, the overall mean absolute relative difference for FSL2 was 8.2%, with a high degree of clinical accuracy. Compared to blood monitoring in DM1, studies show higher time within range, lower time below range and lower time above range at 4, 8 and 12 weeks of FSL2 use. These results were confirmed in observational studies in DM, where the majority of FSL2 users reported greater satisfaction with treatment and a significant improvement in quality of life. In concluded, Including the FSL2 system in the management of people with DM would also reduce the risks associated with DM complications, improving the prognosis of this population and allowing for the appropriate use of healthcare resources.",
+ "PMID": "39225673",
+ "Title": "Journal of psychosocial nursing and mental health services",
+ "ArticleTitle": "Psychiatric Disorders and Diabetes: Review of Guidelines for Collaborative Care.",
+ "Abstract": "Psychiatric disorders and diabetes are highly associated in psychiatric and primary care settings. The purpose of the current article is to examine the risk factors for diabetes among individuals being treated for psychiatric disorders in mental health care settings. Guidelines for promotion of healthy lifestyles, screening for risk factors, early identification and treatment of prediabetes, and collaborative care to manage the disease are discussed. [(9), 7-10.].",
"Predictions": [
- "Diabetes",
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes"
],
"MeshTerms": [
"Humans",
- "Blood Glucose Self-Monitoring",
- "Blood Glucose",
"Diabetes Mellitus",
- "Quality of Life",
- "Diabetes Mellitus, Type 2",
- "Diabetes Mellitus, Type 1",
- "Continuous Glucose Monitoring"
- ]
+ "Health Promotion",
+ "Mental Disorders",
+ "Practice Guidelines as Topic",
+ "Prediabetic State",
+ "Primary Health Care",
+ "Psychiatric Nursing",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "3"
+ }
},
{
- "PMID": "39666397",
- "Title": "Medicina",
- "ArticleTitle": "Risk factors associated with invasive pulmonary aspergillosis in severe COVID-19 patients: a casecontrol study.",
- "Abstract": "A history of diabetes, smoking, coronary artery disease, and a Charlson score equal to or greater than 5 may increase the risk of developing CAPA.",
+ "PMID": "39212678",
+ "Title": "Diabetologia",
+ "ArticleTitle": "The future is here: an overview of technology in diabetes.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Male",
- "Middle Aged",
- "Female",
- "Risk Factors",
- "COVID-19",
- "Invasive Pulmonary Aspergillosis",
- "Retrospective Studies",
- "Case-Control Studies",
- "Aged",
- "Severity of Illness Index",
- "SARS-CoV-2",
- "Smoking",
"Diabetes Mellitus"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39665943",
- "Title": "Nefrologia",
- "ArticleTitle": "Study of the association of markers of central and peripheral arterial stiffness with renal function in patients with arterial hypertension, diabetes mellitus and chronic kidney disease.",
- "Abstract": "Aortic stiffness increases in the presence of vascular risk factors such as hypertension, DM and CKD. This increase is greater when DM and CKD coexist. Increased aortic stiffness is inversely associated with GFR and directly with uALB, and is predictive of decreased GFR and abnormal uALB. The VP",
+ "PMID": "39210025",
+ "Title": "Diabetologia",
+ "ArticleTitle": "Global experiences and personal narratives on diabetes technology and access.",
+ "Abstract": "",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Vascular Stiffness",
- "Male",
- "Renal Insufficiency, Chronic",
- "Female",
- "Middle Aged",
- "Hypertension",
- "Glomerular Filtration Rate",
- "Aged",
- "Biomarkers",
- "Albuminuria",
- "Kidney",
- "Cross-Sectional Studies",
- "Diabetes Mellitus"
- ]
+ "Diabetes Mellitus",
+ "Health Services Accessibility"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39665157",
- "Title": "Clinical science (London, England : 1979)",
- "ArticleTitle": "Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients.",
- "Abstract": "Transglutaminase 2 (TG2) is an enzyme with multiple conformations. In its open conformation, TG2 exhibits transamidase activity linked to fibrosis, arterial remodeling, and endothelial dysfunction, a process enhanced by high glucose in endothelial cells. However, the closed conformation of TG2 contributes to transmembrane signaling and nitric oxide (NO)-dependent vasorelaxation. LDN 27219, a reversible allosteric inhibitor, stabilizes TG2 in its closed conformation. We examined whether pharmacological modulation of TG2 into its closed conformation induces vasorelaxation and enhances endothelium-dependent and independent relaxation in resistance arteries from age-matched diabetic (n = 14) and non-diabetic patients (n = 14) (age 71 (Standard Error of the Mean: \u00b1 2)). Subcutaneous arteries (diameter 133-1013 \u00b5m) were isolated from abdominal fat biopsies. TG2 mRNA expression and transamidase activity were assessed via RT-qPCR and 5-biotin(amido)pentylamine (5-BP) incorporation, while vascular reactivity was measured using wire myography. TG2 mRNA was highly expressed without significant differences between the groups and LDN 27219 induced concentration-dependent vasorelaxation in arteries from both groups. Sex-specific analysis revealed that potentiation of acetylcholine-induced vasorelaxation by LDN 27219 was driven by increased TG2 expression in non-diabetic females, whereas no effect was observed in arteries from non-diabetic males. Among diabetic patients, LDN 27219 increased maximal acetylcholine-induced vasorelaxation in males only. LDN 27219 did not affect endothelium-independent relaxation to sodium nitroprusside in either group. In conclusion, TG2 is expressed in human resistance arteries, and LDN 27219 induced vasorelaxation, selectively enhancing ACh relaxation in non-diabetic females, likely owing to increased TG2 expression. This finding underscores the importance of sex differences in TG2 modulation of vasorelaxation.",
+ "PMID": "39160734",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Glucofriendly couscous usage in diabetes.",
+ "Abstract": "Couscous, a staple food of Northern Africa and the Middle East, is consumed across the world. Being carbohydrate - rich, it is often forbidden to persons with diabetes. Its social and cultural connotations, however, do not allow absolute avoidance of this dish in real life. This brief article explores various ways of preparing, serving and eating couscous, in a glucofriendly manner. The authors summarize available literature, and suggest culinary tips to reduce glycaemic index and glycaemic load of this foodstuff.",
"Predictions": [
"Diabetes"
],
"MeshTerms": [
"Humans",
- "Protein Glutamine gamma Glutamyltransferase 2",
- "Transglutaminases",
- "Male",
- "Female",
- "Aged",
- "Vasodilation",
- "Endothelium, Vascular",
- "GTP-Binding Proteins",
- "Arteries",
- "Vascular Resistance",
- "Sex Factors",
+ "Blood Glucose",
"Diabetes Mellitus",
- "Vasodilator Agents",
- "Enzyme Inhibitors",
- "Middle Aged"
- ]
+ "Dietary Carbohydrates",
+ "Glycemic Index",
+ "Glycemic Load"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "20"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/diabetes_type_1.json b/testModel/dataset/diabetes_type_1.json
index 73c9a17ab..93e3c483a 100644
--- a/testModel/dataset/diabetes_type_1.json
+++ b/testModel/dataset/diabetes_type_1.json
@@ -3,7 +3,7 @@
"PMID": "39737893",
"Title": "Nutrition & diabetes",
"ArticleTitle": "The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.",
- "Abstract": "There is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.",
+ "Abstract": "Diabetes mellitus (DM) and arthritis are prevalent conditions worldwide. The intricate relationship between these two conditions, especially in the context of various subtypes of arthritis, remains a topic of interest.To investigate the relationship between diabetes and arthritis, with a focus on Rheumatoid Arthritis (RA), using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis.Data from six consecutive NHANES cycles from 2007 to 2018 were analyzed, involving 30,062 participants after applying exclusion criteria. The association between diabetes and arthritis was assessed using logistic regression. MR was employed to determine the causal relationship between the two conditions using Genome-Wide Association Study (GWAS) data.The prevalence of arthritis in diabetic patients was almost twice that of non-diabetic patients. Logistic regression showed a significant gross association between arthritis and diabetes with an OR of 2.90 (95% CI: 2.66-3.16). After adjusting for age, gender, race, and other factors, the association yielded an OR of 1.14 (95% CI: 1.00-1.29, p\u2009<\u20090.05). MR analyses indicated a significant association between Type 1 Diabetes and RA (OR\u2009=\u20091.407, p\u2009=\u20090.002), but no significant correlation was observed for Type 2 Diabetes.There is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
@@ -26,7 +26,12 @@
"Genetic Predisposition to Disease",
"Logistic Models",
"Polymorphism, Single Nucleotide"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737643",
@@ -45,13 +50,18 @@
"Diabetes Mellitus, Experimental",
"Diabetes Mellitus, Type 1",
"Male"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736868",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents.",
- "Abstract": "www.ClinicalTrials.gov, identifier NCT03103867.",
+ "Abstract": "To compare impact of pump treatment and continuous glucose monitoring (CGM) with predictive low glucose suspend (SmartGuard) or user initiated CGM (iscCGM) on sleep and hypoglycemia fear in children with type 1 Diabetes and parents.Secondary analysis of data from 5 weeks pump treatment with iscCGM (A) or SmartGuard (B) open label, single center, randomized cross-over study was performed. At baseline and end of treatment arms, sleep and fear of hypoglycemia were evaluated using ActiGraph and questionnaires.31 children (6-14 years, male: 50%) and 30 parents (28-55 years) participated. Total sleep minutes did not differ significantly for children (B vs. A: -9.27; 95% CI [-24.88; 6.34]; p 0.26) or parents (B vs. A: 5.49; 95% CI [-8.79; 19.77]; p 0.46). Neither daytime sleepiness nor hypoglycemia fear in children or parents differed significantly between the systems. Neither group met recommended sleep criteria.Lack of sleep and fear of hypoglycemia remain a major burden for children with diabetes and their parents. Whilst no significant differences between the systems were found, future technology should consider psychosocial impacts of diabetes and related technologies on children and parents' lived experience to ensure parity of esteem between physical and mental health outcomes.www.ClinicalTrials.gov, identifier NCT03103867.",
"Predictions": [
"Diabetes type 1"
],
@@ -74,13 +84,18 @@
"Insulin",
"Blood Glucose",
"Hypoglycemic Agents"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736865",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus - an exploratory study.",
- "Abstract": "Both T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.",
+ "Abstract": "Diabetes mellitus (DM) is a chronic metabolic disorder that increases fragility fracture risk. Conventional DXA-based areal bone mineral density (aBMD) assessments often underestimate this risk. Cortical Backscatter (CortBS) ultrasound, a radiation-free technique, non-invasively analyzes cortical bone's viscoelastic and microstructural properties. This study aimed to evaluate CortBS's discriminative performance in DM patients compared to DXA and characterize changes in cortical bone microstructure in Type 1 and Type 2 DM (T1DM, T2DM) patients.This study included 89 DM patients (T1DM = 39, T2DM = 48) and 76 age- and sex-matched controls. DXA measured aBMD, while CortBS measurements were taken at the anteromedial tibia using a medical ultrasound scanner with custom software. Multivariate analysis of variance assessed the impact of DM type on CortBS and DXA measurement results. Partial least squares discriminant analyses with cross-validation were used to compare the discrimination performance for vertebral, non-vertebral, and any fragility fractures, adjusting for gender, age, and anthropometric parameters (weight, height, BMI).Fractures occurred in 8/23 T1DM, 17/18 T2DM, and 16/55 controls. DXA parameters were reduced in fracture patients, with significant diabetes impact. T2DM was associated with altered CortBS parameters, reduced scatterer density, and larger pores. CortBS outperformed DXA in discriminating fracture risk (0.61 \u2264 AUC(DXA) \u2264 0.63, 0.68 \u2264 AUC(CortBS) \u2264 0.69).Both T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
@@ -100,13 +115,18 @@
"Diabetes Mellitus, Type 1",
"Cortical Bone",
"Elasticity"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39735417",
"Title": "Journal of diabetes research",
"ArticleTitle": "Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation.",
- "Abstract": "Type 1 diabetes (T1D) is an autoimmune chronic disorder that damages beta cells in the pancreatic islets of Langerhans and results in hyperglycemia due to the loss of insulin. Exogenous insulin therapy can save lives but does not stop disease progression. Thus, an effective therapy may require beta cell restoration and suppression of the autoimmune response. However, currently, there are no treatment options available that can reverse T1D. Within the National Clinical Trial (NCT) database, a majority of over 3000 trials to treat T1D are devoted to insulin therapy. This review focuses on noninsulin pharmacological therapies, specifically immunomodulators. Many investigational new drugs fall under this category, such as the recently FDA-approved CD3 monoclonal antibody teplizumab to delay the onset of T1D. In total, we identified 39 different immunomodulatory investigational drugs. FDA-approved teplizumab for Stage 2 T1D is discussed along with other immunomodulators that have been tested in Phase 3 clinical trials or higher, including otelixizumab (another anti-CD3 monoclonal antibody), daclizumab (an anti-CD25 monoclonal antibody), ladarixin (CXCR1/2 inhibitor), and antithymocyte globulin (ATG). Immunomodulators also play roles in islet transplantation and cellular therapies like FDA-approved Lantidra. Several immunomodulators involved in Phase 3 clinical studies of islet transplantation are also discussed, including alemtuzumab, basiliximab, etanercept, and reparixin, some already FDA-approved for other uses. These include alemtuzumab, basiliximab, etanercept, and reparixin, some of which have been FDA-approved for other uses. This review provides background, mechanism of action, results of completed trials, and adverse effects as well as details regarding ongoing clinical trials for each of these immunomodulators. ",
+ "Abstract": "Type 1 diabetes (T1D) is an autoimmune chronic disorder that damages beta cells in the pancreatic islets of Langerhans and results in hyperglycemia due to the loss of insulin. Exogenous insulin therapy can save lives but does not stop disease progression. Thus, an effective therapy may require beta cell restoration and suppression of the autoimmune response. However, currently, there are no treatment options available that can reverse T1D. Within the National Clinical Trial (NCT) database, a majority of over 3000 trials to treat T1D are devoted to insulin therapy. This review focuses on noninsulin pharmacological therapies, specifically immunomodulators. Many investigational new drugs fall under this category, such as the recently FDA-approved CD3 monoclonal antibody teplizumab to delay the onset of T1D. In total, we identified 39 different immunomodulatory investigational drugs. FDA-approved teplizumab for Stage 2 T1D is discussed along with other immunomodulators that have been tested in Phase 3 clinical trials or higher, including otelixizumab (another anti-CD3 monoclonal antibody), daclizumab (an anti-CD25 monoclonal antibody), ladarixin (CXCR1/2 inhibitor), and antithymocyte globulin (ATG). Immunomodulators also play roles in islet transplantation and cellular therapies like FDA-approved Lantidra. Several immunomodulators involved in Phase 3 clinical studies of islet transplantation are also discussed, including alemtuzumab, basiliximab, etanercept, and reparixin, some already FDA-approved for other uses. These include alemtuzumab, basiliximab, etanercept, and reparixin, some of which have been FDA-approved for other uses. This review provides background, mechanism of action, results of completed trials, and adverse effects as well as details regarding ongoing clinical trials for each of these immunomodulators. ClinicalTrials.gov identifier: NCT03875729, NCT01030861, NCT00129259, NCT00385697, NCT01280682; NCT03929601, NCT04598893, NCT05757713, NCT00678886, NCT01123083, NCT00064714, NCT00468117, NCT04628481, NCT01106157, NCT02215200, NCT00331162, NCT00679042, NCT01220856, NCT01817959.",
"Predictions": [
"Diabetes type 1"
],
@@ -118,13 +138,18 @@
"Immunologic Factors",
"Animals",
"Antibodies, Monoclonal, Humanized"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39733989",
"Title": "Diabetes research and clinical practice",
"ArticleTitle": "Duration of physical activity required to Ameliorate hyperglycemia without causing hypoglycemia in type 1 diabetes: A T1DEXI adults and pediatric cohort analyses.",
- "Abstract": "Time-limited activity is an effective means of restoring TIR when hyperglycemia exists in adolescents and adults with T1D.",
+ "Abstract": "To estimate physical activity (activity) duration required to lower glucose from above target range (>180\u00a0mg/dL) to within target range (TIR: 70-180\u00a0mg/dL) in individuals with type 1 diabetes (T1D).Continuous glucose monitoring and activity data were collected from 404 adults (28-day observation) and 149 adolescents (10-day observation) with T1D. Activities (N\u00a0=\u00a01902) with a starting glucose between 181-300 mg/dL, duration 10-60\u00a0min, and no reported meals during activity were included in the analysis. Kaplan-Meier curves were used to estimate activity duration required to drop starting glucose levels from above to within TIR.An overall starting glucose value of 181-199, 200-224, 225-249, and 250-300\u00a0mg/dL required an estimated activity duration of 15, 31, 59, and\u00a0\u2265\u00a060\u00a0min, respectively, to have a 50\u00a0% chance of reducing glucose to be within target range, with a 0-11\u00a0% incidence of hypoglycemia in the hour after activity. Activity duration requirements increased irrespective of starting glucose levels when glucose was trending upwards before activity and with zero bolus insulin on board at the start of activity. Adult and adolescent results were similar.Time-limited activity is an effective means of restoring TIR when hyperglycemia exists in adolescents and adults with T1D.",
"Predictions": [
"Diabetes type 1"
],
@@ -147,7 +172,35 @@
"Time Factors",
"Insulin",
"Blood Glucose Self-Monitoring"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39733497",
+ "Title": "Nurse education today",
+ "ArticleTitle": "School nurses' competency in supporting students with type 1 diabetes: A mixed methods systematic review.",
+ "Abstract": "Aim To evaluate school nurse and family-reported perceptions of school nurse competencies in supporting students with Type 1 diabetes.Mixed methods systematic review of the Joanna Briggs Institute methodology.Five academic databases (PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Embase, and Research Information Sharing Service) were used as data sources.Qualitative, quantitative, and mixed-method studies published between 2014 and 2023 were included. Two authors independently assessed the eligibility and quality of the included studies. The quality of the included studies was evaluated using a mixed methods assessment tool.Thirteen qualitative studies, 11 quantitative studies, seven non-randomized studies, and four mixed studies met the inclusion criteria. Consequently, five competencies and 11 sub-competencies were derived under two themes. The two themes were \"demand for training in school diabetes care\" and \"demand for more active cooperation.\" In particular, the literature confirmed challenges in school nurses' utilization of diabetes devices despite moderate to high confidence in basic diabetes care tasks.This systematic review offered useful information from the perspective of stakeholders (school nurses, parents, and students) regarding school nurses' competencies in caring for students with T1D. This can help us understand the various tasks and requirements faced by school nurses, and future capacity development interventions for school nurses that consider these are needed.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "School Nursing",
+ "Clinical Competence",
+ "Students",
+ "Qualitative Research",
+ "Child"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39733115",
@@ -167,7 +220,12 @@
"Glucose",
"Blood Glucose",
"Models, Biological"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732907",
@@ -186,37 +244,81 @@
"Forecasting",
"Algorithms",
"Reinforcement, Psychology"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39732545",
- "Title": "Endocrinologia, diabetes y nutricion",
- "ArticleTitle": "Nurse-led therapeutic patient education program on glycemic control and emotional wellbeing in adolescents with type 1 diabetes mellitus during hospital transition.",
- "Abstract": "The structured therapeutic education program for adolescents with T1DM transitioning from pediatric to adult care maintains glycemic control and emotional wellbeing.",
+ "PMID": "39731973",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "The relationship between residual insulin secretion and subclinical cardiovascular risk indices in young adults with type 1 diabetes.",
+ "Abstract": "Patients with type 1 diabetes (DM1), even in the setting of adequate glycaemic control, have an excess risk for developing cardiovascular disease. Residual insulin secretion (RIS), measured by detectable C-peptide levels in patients with DM1, might protect against diabetes-related complications. This study aimed to examine the relationship between residual insulin secretion and prognostic markers of cardiovascular complications in patients with DM1.A total of 137 patients with DM1 were included in this analysis. They were of young age (<45 years), with an established diagnosis of over two years before the study entry and without a history of cardiovascular complications. All patients underwent complete clinical and laboratory evaluation. A c-peptide measurement of \u22650.05 ng/ml was used to identify the presence of RIS. Pulse wave velocity (PWV), cardiac autonomic function assessed both at rest, by total power of heart rate variability and dynamically, by the expiration to inspiration (e/i) index, albumin to creatinine ratio (ACR), and high sensitivity CRP (hs-CRP) were used as predictive biomarkers of cardiovascular complications.Female participants represented 63.5% of the population [mean age: 29.7 (\u00b18.1) years, mean HbA1c: 7.6% (\u00b11.4), median diabetes duration:15 (10-21) years, median age at diabetes diagnosis: 13 (8-17) years]]. The median value of fasting c-peptide was 0.04 (0.03-0.05) ng/ml, and RIS was detected in 32 patients (23.4%). Patients with RIS had a shorter diabetes duration, an older age at diagnosis and a lower BMI, while no significant association was found between residual c-peptide and age or HbA1c. RIS was significantly associated with lower PWV values [8.1 m/s\u00b2 (7-8.7) vs 9.2 m/s\u00b2 (7.8-10.1), p <0,001], higher total power values [1124 Hz (600-3277) vs 577 Hz (207-2091), p <0,001], and higher E/I measurements [1.4 (1.2-1.5) vs. 1.3 (1.2-1.4), p=0.01]. No significant association was noted between RIS and either ACR or hs-CRP. In multivariable linear regression analysis, the association between RIS and lower PWV values remained significant (p= 0.007) regardless of age, sex, diabetes duration or age of diagnosis, blood pressure and BMI. Similarly, residual insulin secretion retained a significant independent association with total power (p= 0.032) and E/I (p=0.045).In young patients with DM1, free of macrovascular complications, residual insulin secretion is independently associated with more favorable prognostic markers of subclinical atherosclerosis and cardiac autonomic function.",
"Predictions": [
- "Mental Health",
+ "Cardiovascular diseases",
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Adolescent",
+ "Female",
+ "Male",
+ "Adult",
+ "Cardiovascular Diseases",
+ "Young Adult",
+ "Insulin Secretion",
+ "C-Peptide",
+ "Heart Disease Risk Factors",
+ "Pulse Wave Analysis",
+ "Insulin",
+ "Diabetic Angiopathies",
+ "Biomarkers",
+ "Prognosis",
+ "Adolescent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "39731516",
+ "Title": "Journal of pediatric psychology",
+ "ArticleTitle": "Psychosocial correlates of alcohol and substance use in college youth with type 1 diabetes.",
+ "Abstract": "Adolescents and young adults with chronic diseases face unique challenges during the college years and may consume alcohol and other substances to cope with stressors. This study aimed to assess the patterns of substance use and to determine psychosocial correlates of these behaviors among college youth with type 1 diabetes (T1D).College youth with T1D were recruited via social media and direct outreach into a web-based study. Participants answered validated questions about substance use, and they completed validated screeners of depressive and anxiety symptoms (PHQ-2 and GAD-2), illness acceptance (ICQ), interpersonal support (ISEL), and grit (Grit scale). Descriptive statistics, bivariate analyses, and multivariable regression evaluated substance use behaviors as a function of psychosocial factors while adjusting for age and sex.Alcohol (84.06%) and marijuana (41.30%) were the most common substances reported. In bivariate analyses, depressive symptoms were positively associated (p\u2009=\u2009.01) and illness acceptance was inversely associated (p\u2009=\u2009.02) with marijuana use. Higher grit scores were inversely associated with marijuana use (p\u2009<\u2009.001) and prescription drug misuse (p\u2009=\u2009.04). The significant associations between marijuana use and depressive symptoms (adjusted odds ratio [AOR] 1.31, 95% confidence interval [CI] 1.04-1.66), illness acceptance (AOR 0.96, 95% CI 0.91-0.99), and grit (AOR 0.32, 95% CI 0.17-0.60) persisted after adjustment for age and sex.Substance use is prevalent among college youth with T1D. While psychosocial factors such as depressive symptoms may confer an increased risk, illness acceptance and grit may be protective-especially against marijuana use. Providers should address both positive and negative psychosocial factors to mitigate substance use in this population.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
"Male",
+ "Diabetes Mellitus, Type 1",
"Female",
- "Patient Education as Topic",
- "Glycemic Control",
- "Transition to Adult Care",
- "Self Care",
- "Emotions",
- "Mental Health",
- "Feeding and Eating Disorders"
- ]
+ "Adolescent",
+ "Young Adult",
+ "Students",
+ "Universities",
+ "Depression",
+ "Substance-Related Disorders",
+ "Anxiety",
+ "Alcohol Drinking",
+ "Adult",
+ "Marijuana Use"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39731141",
"Title": "BMC endocrine disorders",
"ArticleTitle": "Prevalence and associated factors of psychiatric problems in children aged 6-18 years with type-1 diabetes mellitus in Gondar, Ethiopia: a cross-sectional study.",
- "Abstract": "The prevalence of psychiatric problems in diabetic children was significantly high and children living with single parent, paternal educational status, glycemic control, family history of diabetes, and family size were found to have significant association with the occurrence of psychiatric problems in diabetic children.",
+ "Abstract": "Diabetes mellitus is one of the most common chronic illnesses in children with multiple psychosocial, economic and developmental effects. Psychiatric disorders such as depression, anxiety, psychological distress, and eating disorders are more common in diabetic patients than the non-diabetic once. The main objective of our study was to assess Prevalence and associated factors of psychiatric problems in children aged 6-18 years with type 1 diabetes mellitus in Gondar, Ethiopia.An institution-based cross-sectional study was conducted among 206 children aged 6-18 years with type-1 diabetes mellitus having regular follow-ups at the University of Gondar comprehensive and Specialized Hospital (UoGCSH) over three three-month period. Data was collected by trained physicians using interviewer-administered structured questionnaires. Convenient sampling technique was applied and Participants were selected sequentially until the sample size was achieved. Both bivariate and multivariate logistic regression analyses were used for Model fitness and the strength of association was determined using an OR, p-value of <\u20090.05 and 95% CI.The prevalence of psychiatric problems was 11.7% and those children living with only either of the parent (AOR\u2009=\u20098.39, 95%: 1.5-46), living with other relatives (AOR\u2009=\u200911.3, 95% CI: 1.97-64.7), more than 5 family size (AOR\u2009=\u20090.3, 95%CI: 0.1-1.2), fathers attended formal education (AOR\u2009=\u20090.3, 95%: 0.04-1.73), a patient having good glycemic control (AOR\u2009=\u20090.2, 95%: 0.04-0.67) and those with a family history of diabetes mellitus(AOR\u2009=\u20095.2, 95% CI: 1.2-22.1) were significantly associated with a psychiatric problem in diabetic aged 6-18 years with p-value\u2009<\u20090.05.The prevalence of psychiatric problems in diabetic children was significantly high and children living with single parent, paternal educational status, glycemic control, family history of diabetes, and family size were found to have significant association with the occurrence of psychiatric problems in diabetic children.",
"Predictions": [
"Diabetes type 1"
],
@@ -233,13 +335,18 @@
"Mental Disorders",
"Risk Factors",
"Follow-Up Studies"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39730838",
"Title": "Scientific reports",
"ArticleTitle": "Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches.",
- "Abstract": "A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a more direct approach and is now increasingly used in clinical and research studies. We investigated the concordance between WGS-based and array-based T1DGRS across genetic ancestries in 149,265 UK Biobank participants using WGS, TOPMed-imputed, and 1000 Genomes-imputed array genotypes. In the overall cohort, WGS-based T1DGRS demonstrated strong correlation with TOPMed-imputed array-based score (r\u2009=\u20090.996, average WGS-based score 0.0028 standard deviations (SD) lower, p\u2009<\u200910",
+ "Abstract": "A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a more direct approach and is now increasingly used in clinical and research studies. We investigated the concordance between WGS-based and array-based T1DGRS across genetic ancestries in 149,265 UK Biobank participants using WGS, TOPMed-imputed, and 1000 Genomes-imputed array genotypes. In the overall cohort, WGS-based T1DGRS demonstrated strong correlation with TOPMed-imputed array-based score (r\u2009=\u20090.996, average WGS-based score 0.0028 standard deviations (SD) lower, p\u2009<\u200910), while showing lower correlation with 1000 Genomes-imputed array-based scores (r\u2009=\u20090.981, 0.043 SD lower in WGS, p\u2009<\u200910). Ancestry-stratified analyses between WGS-based and TOPMed-imputed array-based score showed the highest correlation with European ancestry (r\u2009=\u20090.996, 0.044 SD lower in WGS, p\u2009<\u200910) followed by African ancestry (r\u2009=\u20090.989, 0.0193 SD lower in WGS, p\u2009<\u200910) and South Asian ancestry (r\u2009=\u20090.986, 0.0129 SD lower in WGS, p\u2009<\u200910\u2009). These differences were more pronounced when comparing WGS based score with 1000 Genomes-imputed array-based scores (r\u2009=\u20090.982, 0.975, 0.957 for European, South Asian, African respectively). Population-level analysis using WGS-based T1DGRS revealed significant ancestry-based stratification, with European ancestry individuals showing the highest scores, followed by South Asian (average 0.28 SD lower than Europeans, p\u2009<\u200910) and African ancestry individuals (average 0.89 SD lower than Europeans, p\u2009<\u200910). Notably, when applying the European ancestry-derived 90 centile risk threshold, only 0.71% (95% CI 0.41-1.13) of African ancestry individuals and 6.4% (95% CI 5.6-7.2) of South Asian individuals were identified as high-risk, substantially below the expected 10%. In conclusion, while WGS is viable for generating T1DGRS, with TOPMed-imputed genotypes offering a cost-effective alternative, the persistence of ancestry-based variations in T1DGRS distribution even using whole genome sequencing emphasises the need for ancestry-specific or pan-ancestry standards in clinical practice.",
"Predictions": [
"Diabetes type 1"
],
@@ -258,13 +365,18 @@
"Polymorphism, Single Nucleotide",
"Whole Genome Sequencing",
"Racial Groups"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39728423",
"Title": "Medical sciences (Basel, Switzerland)",
"ArticleTitle": "An Unusual Case of Nephrotic Range Proteinuria in a Short-Standing Type 1 Diabetic Patient with Newly Diagnosed Systemic Lupus Erythematosus: A Case Report and Literature Review.",
- "Abstract": "Lupus podocytopathy is an infrequent anatomopathological entity, so this case is presented as the first reported in Peru, and a literature review is made.",
+ "Abstract": "Lupus podocytopathy (LP) is a non-immune complex-mediated glomerular lesion in systemic lupus erythematosus (SLE), characterized by the diffuse effacement of podocyte processes without immune complex deposition or with only mesangial immune complex deposition. LP is a rare cause of nephrotic syndrome in SLE patients with implications for prognosis and treatment.We present the case of a 28-year-old woman with a medical history of type 1 diabetes mellitus (T1DM) who presented with lower limb edema, dyspnea, hypercholesterolemia, with nephrotic range proteinuria, without acute kidney injury, and laboratory findings compatible with auto-immune hemolytic anemia. They had negative infectious serology, positive antinuclear antibody (ANA), and an eye fundus examination showing diabetic retinopathy. A biopsy was performed to define the etiology of the renal involvement, which was compatible with LP. Following immuno-suppressive and antiproteinuric therapy, the patient evolved with the complete remission of the nephrotic syndrome.Lupus podocytopathy is an infrequent anatomopathological entity, so this case is presented as the first reported in Peru, and a literature review is made.",
"Predictions": [
"Diabetes type 1"
],
@@ -277,13 +389,42 @@
"Proteinuria",
"Nephrotic Syndrome",
"Podocytes"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39728025",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Smoking and diabetic nephropathy: An updated systematic review and meta-analysis.",
+ "Abstract": "Several studies have reported the potential association between smoking and diabetic nephropathy. However, the studies of non-significant association results were against the association between smoking and diabetic nephropathy. Therefore, the relationship between smoking and diabetic nephropathy was still debated and controversial.Prospective cohort studies were included in the current meta-analysis. The tobacco smoking (current smokers or former smokers) and non-smoking groups in the enrolled studies were compared for the hazard ratio (HR) of diabetic nephropathy. Fifteen studies with 221,821 subjects were included in this meta-analysis. Subgroup analysis of the type 1 diabetes and type 2 diabetes groups was also performed individually to investigate the effects of different types of diabetes on the relationship between smoking and diabetic nephropathy.Current smoking was significantly associated with a greater log HR of diabetic nephropathy [1.44 (1.22-1.70), Z\u2009=\u20094.39]. In addition, former smoking was significantly associated with diabetic nephropathy [log HR\u2009=\u20091.04 (1.03-1.05), Z\u2009=\u20098.02]. The individual subgroup analysis of type 1 diabetes and type 2 diabetes subjects showed that smoking might be both significantly associated with greater log HRs of diabetic nephropathy.Current and former smoking might be the risk factors for diabetic nephropathy in the current meta-analytic results. The phenomenon of such significant associations were discovered in type 1 and 2 diabetes.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Nephropathies",
+ "Smoking",
+ "Risk Factors",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Prospective Studies"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39727851",
"Title": "Biosensors",
"ArticleTitle": "Sensing Biomechanical Alterations in Red Blood Cells of Type 1 Diabetes Patients: Potential Markers for Microvascular Complications.",
- "Abstract": "In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability, allowing them to undergo considerable deformation when passing through the microcirculation. However, this deformability is compromised in Type 1 diabetes mellitus (T1DM) and related pathological conditions. This study aims to investigate the biomechanical properties of RBCs in T1DM patients, focusing on identifying significant mechanical alterations associated with microvascular complications (MCs). We conducted a case-control study involving 38 T1DM subjects recruited from the Diabetes Care Unit at Fondazione Policlinico Gemelli Hospital, comprising 22 without MCs (control group) and 16 with MCs (pathological group). Atomic Force Microscopy was employed to assess RBC biomechanical properties in a liquid environment. We observed significant RBC stiffening in individuals with MCs, particularly during large indentations that mimic microcirculatory deformations. Univariate analysis unveiled significant differences in RBC stiffness (median difference 0.0006 N/m, ",
+ "Abstract": "In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability, allowing them to undergo considerable deformation when passing through the microcirculation. However, this deformability is compromised in Type 1 diabetes mellitus (T1DM) and related pathological conditions. This study aims to investigate the biomechanical properties of RBCs in T1DM patients, focusing on identifying significant mechanical alterations associated with microvascular complications (MCs). We conducted a case-control study involving 38 T1DM subjects recruited from the Diabetes Care Unit at Fondazione Policlinico Gemelli Hospital, comprising 22 without MCs (control group) and 16 with MCs (pathological group). Atomic Force Microscopy was employed to assess RBC biomechanical properties in a liquid environment. We observed significant RBC stiffening in individuals with MCs, particularly during large indentations that mimic microcirculatory deformations. Univariate analysis unveiled significant differences in RBC stiffness (median difference 0.0006 N/m, = 0.012) and RBC counts (median difference -0.39 \u00d7 10/L, = 0.009) between the MC and control groups. Bivariate logistic regression further demonstrated that combining these parameters could effectively discriminate between MC and non-MC conditions, achieving an AUC of 0.82 (95% CI: 0.67-0.97). These findings reveal the potential of RBC biomechanical properties as diagnostic and monitoring tools in diabetes research. Exploring RBC mechanical alterations may lead to the development of novel biomarkers, which, in combination with clinical markers, could facilitate the early diagnosis of diabetes-related complications.",
"Predictions": [
"Diabetes type 1"
],
@@ -299,13 +440,18 @@
"Biomarkers",
"Middle Aged",
"Microscopy, Atomic Force"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39727210",
"Title": "Journal of the American Heart Association",
"ArticleTitle": "Inflammatory Markers and Measures of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.",
- "Abstract": "URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02936843, NCT02017171.",
+ "Abstract": "Cardiovascular autonomic neuropathy (CAN) and inflammation predict more severe outcomes in type 1 diabetes (T1D). However, the link between CAN and inflammation in T1D remains unclear. We examined associations between CAN measures and inflammatory biomarkers in individuals with T1D.In a cross-sectional study, we measured cardiovascular autonomic reflex tests and heart rate variability (established CAN measures) and a panel of 39 inflammatory biomarkers, including soluble urokinase plasminogen activator receptor (suPAR), in T1D participants of the TINSAL-T1DN (Targeting Inflammation with Salsalate in Individuals with T1D Neuropathy) trial (n=57, discovery), and the PERL (Preventing Early Renal Loss in Diabetes) trial (n=468, validation). Amongst 39 inflammatory biomarkers measured in TINSAL-T1DN, suPAR levels had the strongest negative correlations with CAN measures: expiration/inspiration (=-0.48), Valsalva (=-0.28), 30:15 (=-0.37), SD of the normal RR interval (=-0.37), and root mean square of differences of successive RR intervals (=-0.31) (all <0.05). Findings were validated in PERL. In unadjusted analyses, median suPAR levels significantly differed between the lowest and highest SD of the normal RR interval tertiles (3.79 versus 3.12\u2009ng/mL, <0.001) and root mean square of differences of successive RR intervals (3.76 versus 3.17\u2009ng/mL, <0.001). After adjusting for covariates (age, sex, hemoglobin A1c, and estimated glomerular filtration rate), median suPAR values remained significantly elevated in the lowest tertiles of SD of the normal RR interval (=0.004) and root mean square of differences of successive RR intervals (=0.006).Amongst several inflammatory biomarkers, suPAR, an immune-mediated glycoprotein, has a singular association with CAN measures. The potential of targeting suPAR as a disease-modifying approach for CAN in T1D warrants further exploration.URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02936843, NCT02017171.",
"Predictions": [
"Cardiovascular diseases",
"Diabetes type 1"
@@ -328,13 +474,18 @@
"Inflammation",
"Inflammation Mediators",
"Receptors, Urokinase Plasminogen Activator"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39726058",
"Title": "Journal of medical case reports",
"ArticleTitle": "Immune checkpoint inhibitor-associated diabetic ketoacidosis and insulin-dependent diabetes: a case report.",
- "Abstract": "This case report underscores the risk of diabetic ketoacidosis linked to nivolumab, even in patients without predisposing factors, emphasizing the need for increased vigilance among both oncologists and physicians. It highlights the importance of monitoring for new-onset diabetes and diabetic ketoacidosis, whether immunotherapy is active or discontinued, and ensuring comprehensive care including hospitalization, insulin management, and diabetes education if diabetic ketoacidosis is diagnosed.",
+ "Abstract": "Immunotherapy, including the use of immune checkpoint inhibitors such as nivolumab, is increasingly common in cancer treatment and can lead to various immune-related adverse effects, including rare cases of diabetic ketoacidosis. This case report highlights an unique instance of nivolumab-induced diabetic ketoacidosis in a patient without prior history of diabetes, emphasizing the importance of careful monitoring even in those without traditional risk factors.We report a case of a 70-year-old Caucasian male with metastatic esophageal adenocarcinoma who developed diabetic ketoacidosis 3\u00a0weeks after stopping nivolumab therapy. The patient had no previous history of diabetes, nor had he used sodium-glucose transport protein 2 inhibitors or corticosteroids. Diagnostic tests confirmed diabetic ketoacidosis, and while he was initially treated following the institutional protocol, he continued to require insulin therapy indefinitely.This case report underscores the risk of diabetic ketoacidosis linked to nivolumab, even in patients without predisposing factors, emphasizing the need for increased vigilance among both oncologists and physicians. It highlights the importance of monitoring for new-onset diabetes and diabetic ketoacidosis, whether immunotherapy is active or discontinued, and ensuring comprehensive care including hospitalization, insulin management, and diabetes education if diabetic ketoacidosis is diagnosed.",
"Predictions": [
"Diabetes type 1"
],
@@ -350,7 +501,12 @@
"Adenocarcinoma",
"Hypoglycemic Agents",
"Antineoplastic Agents, Immunological"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39725378",
@@ -372,7 +528,45 @@
"Schistosoma mansoni",
"Islets of Langerhans",
"Acute Disease"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39725095",
+ "Title": "International journal of biological macromolecules",
+ "ArticleTitle": "Propionate-functionalized chitosan hydrogel nanoparticles for effective oral delivery of insulin.",
+ "Abstract": "Oral delivery of macromolecular drugs is often hampered by the harsh gastrointestinal environment, which makes the drugs have poor bioavailability. Insulin, the most used drug for diabetes, also faces the same challenge for oral administration. Hence, we decorated microbial metabolite propionate on chitosan (CS) to fabricate insulin-loaded propionate-modified CS hydrogel nanoparticles (IN-CS/PA HNPs). The prepared IN-CS/PA HNPs exhibited high encapsulation efficiency (> 95\u00a0%) and loading capacity (\u223c10\u00a0%) for insulin. The system provided better protection for insulin in gastrointestinal environment compared to unmodified IN-CS HNPs. Moreover, the active functional group of propionate can be recognized and transported by mono-carboxylate transporter protein 1 (MCT1) targeting. Thus, in both Caco-2 cells and the ligated intestinal loops of rats, IN-CS/PA HNPs significantly improved permeability and uptake of insulin on intestinal epithelium, which was attributed to MCT1-mediated endocytosis. In type 1 diabetic (T1D) rats, oral delivery of IN-CS/PA HNPs with 60\u00a0IU/kg insulin led to more stable and long-lasting hypoglycemic effect than a 5IU/kg dose of subcutaneously injected insulin. It also generated 2.29-fold and 11.88-fold higher relative oral bioavailability compared with empty IN-CS HNPs and free insulin, respectively. This study demonstrated that propanoic acid-functionalized chitosan hydrogel nanoparticles could improve the oral absorption of insulin by overcoming multiple barriers in gastrointestinal tract, providing a promising active targeting strategy for the oral delivery of macromolecules drugs.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Chitosan",
+ "Animals",
+ "Nanoparticles",
+ "Administration, Oral",
+ "Insulin",
+ "Humans",
+ "Caco-2 Cells",
+ "Rats",
+ "Propionates",
+ "Hydrogels",
+ "Drug Carriers",
+ "Diabetes Mellitus, Experimental",
+ "Male",
+ "Hypoglycemic Agents",
+ "Biological Availability",
+ "Drug Delivery Systems",
+ "Diabetes Mellitus, Type 1"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39724143",
@@ -394,16 +588,18 @@
"T-Lymphocytes",
"Male",
"Female"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
},
{
"PMID": "39720308",
"Title": "Journal of diabetes research",
"ArticleTitle": "Young-Onset Diabetes in Sri Lanka: Experience From the Developing World.",
- "Abstract": {
- "b": "Conclusion:",
- "i": "p"
- },
+ "Abstract": "Young-onset diabetes (YOD) is characterised by unique diagnostic and management challenges more pronounced in resource-limited settings like Sri Lanka. We aimed to ascertain the prevalence, patterns and characteristics of YOD in Sri Lanka and describe the state of care. Retrospective review of baseline data of all patients enrolled in the prospective multicentre Database for Young-Onset Diabetes, Sri Lanka (DYOD-SL), was performed, from April 2021 to April 2023. A total of 2531 patient data were included from 28 centres island-wide. Females were 57.6%. The median age was 20 years (interquartile range (IQR) 17, 23), and the age at diagnosis was 15 years (IQR 12, 18). Type 1 diabetes (T1D) was the commonest (57.6%), followed by Type 2 diabetes (T2D) at 34.3%. Younger age at disease onset ( < 0.001), lower BMI ( < 0.001), and diabetic ketoacidosis (DKA) at presentation ( < 0.001) favoured T1D. In the total cohort, the median HbA1c was 9.8% (IQR 7.8, 12.1) with younger patients having poorer control ( = 0.001). Prevalence of nephropathy was 8.1%, retinopathy was 6.6%, neuropathy was 4.1%, moderate-high-risk diabetic foot disease was 1.9%, and macrovascular complications were 0.5%. Hypertension and dyslipidaemia occurred in 2.7% and 14%, respectively. Among patients > 18\u2009years, overweight and obese were 22.2% and 10.4%. Corresponding prevalence in the 5-18-year age group was 20% and 14.7%. Among the insulin users (76%) in the total cohort, the majority (64.7%) were on premixed-based insulin regimens delivered by syringes. Self-monitoring of blood glucose (BG) was reported in 71.3% of the total population. None were on continuous/flash glucose monitoring or insulin pumps. T1D was the commonest subtype of YOD in this hospital-based population. However, T2D was notably higher and is of significant concern. Overall, suboptimal glycaemic control and high rate of complications were noted along with substandard insulin regimens and BG monitoring.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
@@ -425,13 +621,18 @@
"Adult",
"Glycated Hemoglobin",
"Diabetic Ketoacidosis"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39720253",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Sclerostin as a new target of diabetes-induced osteoporosis.",
- "Abstract": "Sclerostin, a protein synthesized by bone cells, is a product of the ",
+ "Abstract": "Sclerostin, a protein synthesized by bone cells, is a product of the gene. Sclerostin is a potent soluble inhibitor of the WNT signaling pathway, and is known to inhibit bone formation by inhibiting osteocyte differentiation and function. Currently, sclerostin has been the subject of numerous animal experiments and clinical investigations. By conducting a literature review, we have gained insights into the most recent advancements in research. Patients with both type 1 diabetes and type 2 diabetes have high levels of serum sclerostin. Patients with type 1 diabetes and type 2 diabetes are both more likely to suffer from osteoporosis, and serum sclerostin levels are elevated in osteoporosis. Many studies have confirmed that sclerostin has been implicated in the pathogenesis of osteoporosis, so we speculate that sclerostin plays an important role in osteoporosis through the glucose metabolism pathway, which may promote the osteoporosis of morbidity in type 1 diabetes and type 2 diabetes. Based on this, we propose whether serum sclerostin can predict type 1 diabetes and type 2 diabetes-induced osteoporosis, and whether it can be a new target for the prevention and treatment of type 1 diabetes and type 2 diabetes-induced osteoporosis, providing new ideas for clinicians and researchers.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
@@ -446,7 +647,12 @@
"Genetic Markers",
"Wnt Signaling Pathway",
"Bone Morphogenetic Proteins"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39719890",
@@ -469,13 +675,18 @@
"Diabetes Mellitus, Type 1",
"Male",
"Drug Delivery Systems"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "25"
+ }
},
{
"PMID": "39718005",
"Title": "Endocrinology, diabetes & metabolism",
"ArticleTitle": "Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes.",
- "Abstract": "Clinical and socio-economic factors significantly influence OGC in type 1 diabetes. The application of statistical models offers a reliable means of predicting the likelihood of achieving OGC following isCGM system implementation.",
+ "Abstract": "To investigate the impact of clinical and socio-economic factors on glycaemic control and construct statistical models to predict optimal glycaemic control (OGC) after implementing intermittently scanned continuous glucose monitoring (isCGM) systems.This retrospective study included 1072 type 1 diabetes patients (49.0% female) from three centres using isCGM systems. Clinical data and net income from the census tract were collected for each individual. OGC was defined as time in range >\u200970%, with time below 70\u2009mg/dL <\u20094%. The sample was randomly split in two equal parts. Logistic regression models to predict OGC were developed in one of the samples, and the best model was selected using the Akaike information criterion and adjusted for Pearson's and Hosmer-Lemeshow's statistics. Model reliability was assessed via external validation in the second sample and internal validation using bootstrap resampling.Out of 2314 models explored, the most effective predictor model included annual net income per person, sex, age, diabetes duration, pre-isCGM HbA1c, insulin dose/kg, and the interaction between sex and HbA1c. When applied to the validation cohort, this model demonstrated 72.6% specificity, 67.3% sensitivity, and an area under the curve (AUC) of 0.736. The AUC through bootstrap resampling was 0.756. Overall, the model's validity in the external cohort was 80.4%.Clinical and socio-economic factors significantly influence OGC in type 1 diabetes. The application of statistical models offers a reliable means of predicting the likelihood of achieving OGC following isCGM system implementation.",
"Predictions": [
"Diabetes type 1"
],
@@ -496,1896 +707,1901 @@
"Adolescent",
"Young Adult",
"Time Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "24"
+ }
},
{
- "PMID": "39716288",
- "Title": "The international journal of behavioral nutrition and physical activity",
- "ArticleTitle": "The efficacy of using continuous glucose monitoring as a behaviour change tool in populations with and without diabetes: a systematic review and meta-analysis of randomised controlled trials.",
- "Abstract": "CRD42024514135.",
+ "PMID": "39642862",
+ "Title": "Cell stem cell",
+ "ArticleTitle": "Stem cell islet replacement in type 1 diabetes: From \"shelf\" to \"self\".",
+ "Abstract": "Recently in Cell, Wang and colleagues report the functional cure of a patient with type 1 diabetes after transplantation of autologous, induced pluripotent stem cell (iPSC)-derived islets in the rectus abdominis muscle.",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
- "Humans",
- "Randomized Controlled Trials as Topic",
- "Blood Glucose Self-Monitoring",
- "Diabetes Mellitus, Type 2",
- "Blood Glucose",
- "Exercise",
- "Health Behavior",
"Diabetes Mellitus, Type 1",
- "Female",
- "Adult",
- "Glycated Hemoglobin",
- "Pregnancy",
- "Continuous Glucose Monitoring"
- ]
+ "Humans",
+ "Islets of Langerhans Transplantation",
+ "Induced Pluripotent Stem Cells",
+ "Islets of Langerhans",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "7"
+ }
},
{
- "PMID": "39715178",
- "Title": "The American journal of occupational therapy : official publication of the American Occupational Therapy Association",
- "ArticleTitle": "Telehealth Occupation-Based Coaching for Rural Parents of Children With Type 1 Diabetes: A Randomized Controlled Trial.",
- "Abstract": "OBC may be more efficacious in helping families to improve health management routines after a child's diagnosis with T1D than usual endocrinology care alone. Most child health outcomes were in target range at the start of the study; therefore, it was not expected to see significant improvements. Plain-Language Summary: Occupational therapy is an untapped resource in the provision of care for children with Type 1 diabetes (T1D). Occupational therapy practitioners can also provide families with evidence-based support to address the self-management skills of children with this chronic condition. This clinical trial examined the preliminary efficacy of a new 12-wk telehealth occupational therapy intervention for rural families with a child living with T1D to improve caregiver diabetes management skills, family participation, and child health. Families who received occupational therapy services were more likely to improve their family participation in meaningful activities and diabetes self-efficacy; however, there were no differences in the child's health outcomes or the family's quality of life.",
+ "PMID": "39603888",
+ "Title": "Trends in immunology",
+ "ArticleTitle": "How do autoimmune CD4 T cells handle exhaustion?",
+ "Abstract": "Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4 T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L CD4 T cells seems to sustain the local autoimmune response.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Animals",
+ "CD4-Positive T-Lymphocytes",
"Humans",
"Diabetes Mellitus, Type 1",
- "Female",
- "Male",
- "Telemedicine",
- "Child",
- "Quality of Life",
- "Rural Population",
- "Child, Preschool",
- "Parents",
- "Mentoring",
- "Occupational Therapy",
- "Double-Blind Method",
- "Pilot Projects",
- "Glycated Hemoglobin",
- "Self Efficacy",
- "Adult",
- "Parenting"
- ]
+ "Mice",
+ "Autoimmunity",
+ "Hepatocyte Nuclear Factor 1-alpha",
+ "Islets of Langerhans"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "28"
+ }
},
{
- "PMID": "39714936",
- "Title": "NEJM evidence",
- "ArticleTitle": "Automated Insulin Delivery in Older Adults with Type 1 Diabetes.",
- "Abstract": "In older adults with type 1 diabetes, automated insulin delivery decreased hypoglycemia compared with sensor-augmented pump delivery. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; ClinicalTrials.gov number: NCT04016662.).",
+ "PMID": "39601386",
+ "Title": "Internal medicine journal",
+ "ArticleTitle": "Results of an Australian trial of an automated insulin delivery (AID) system and other studies support likely benefit of AID use for many Australian adults with type 1 diabetes.",
+ "Abstract": "Less than 20% of Australians with type 1 diabetes (T1D) meet recommended glucose targets. Technology use is associated with better glycaemia, with the most advanced being automated insulin delivery (AID) systems, which are now recommended as gold-standard T1D care. Our Australian AID trial shows a wide spectrum of adults with T1D can achieve recommended targets. Other studies, including lived experience data, are supportive. Insulin pumps are not subsidised for most Australian adults with T1D. We advocate change.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Humans",
"Diabetes Mellitus, Type 1",
- "Female",
- "Aged",
- "Male",
+ "Humans",
"Insulin Infusion Systems",
+ "Australia",
"Insulin",
- "Cross-Over Studies",
- "Aged, 80 and over",
+ "Adult",
"Hypoglycemic Agents",
"Blood Glucose",
- "Hypoglycemia",
- "Glycated Hemoglobin",
- "Blood Glucose Self-Monitoring"
- ]
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Glycated Hemoglobin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "27"
+ }
},
{
- "PMID": "39710861",
- "Title": "Journal of pediatric endocrinology & metabolism : JPEM",
- "ArticleTitle": "Patterns and determinants of serum amylase, lipase concentrations in Indian adolescents and youth with type 1 diabetes.",
- "Abstract": "We have characterized amylase and lipase concentrations across puberty; poor glycemic control tended to be associated with lower amylase and higher lipase, though these findings did not reach statistical significance. Amylase and lipase concentrations should be monitored in Indian adolescents with T1D, particularly in those with poor metabolic control, puberty, uncontrolled hypothyroidism, or reduced calcium intake, while further longitudinal and larger studies are needed to generalize these findings.",
+ "PMID": "39577496",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Evaluation of spatiotemporal associations between COVID-19 pandemic waves and the incidence of pediatric type 1 diabetes in Germany considering time lags: A register-based ecological study.",
+ "Abstract": "To analyze the ecological relationship between COVID-19 incidence in the total population and type 1 diabetes (T1D) incidence in children and adolescents, spatiotemporal models were applied considering time lags from 0 to 12\u00a0months. The results do not indicate a positive correlation between COVID-19 incidence and T1D incidence.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Adolescent",
- "Female",
"Diabetes Mellitus, Type 1",
- "Male",
- "Cross-Sectional Studies",
+ "COVID-19",
"Child",
- "Lipase",
- "India",
- "Amylases",
- "Biomarkers",
- "Young Adult",
- "Follow-Up Studies",
- "Glycated Hemoglobin",
- "Prognosis",
- "Adult",
- "Exocrine Pancreatic Insufficiency"
- ]
+ "Incidence",
+ "Adolescent",
+ "Germany",
+ "Child, Preschool",
+ "Registries",
+ "Spatio-Temporal Analysis",
+ "Male",
+ "Female",
+ "SARS-CoV-2",
+ "Infant",
+ "Pandemics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "23"
+ }
},
{
- "PMID": "39709470",
- "Title": "Cardiovascular diabetology",
- "ArticleTitle": "Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.",
- "Abstract": "Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated with widespread vascular disease affecting both the kidney and the heart from an early stage. However, the risk of diabetic nephropathy in people with type 1 diabetes is strongly genetically determined, as documented in familial transmission studies. The search for the underlying genes has been extensive, using specific hypotheses, sibling linkage studies and genome-wide association studies (GWAS). The role of the angiotensinI-converting enzyme/kininase II (ACE) gene and genetic variability in ACE levels as a susceptibility and prognostic factor for diabetic nephropathy has been well documented in people with type 1 diabetes. The ACE gene insertion/deletion polymorphism, which is associated with plasma and tissue ACE levels, has been the most studied genomic variant in diabetic nephropathy. Recently, this polymorphism has also been associated with longevity in people with type 1 diabetes. The ACE I/D polymorphism has also been associated with vascular, extra-renal complications including myocardial infarction and lower-limb amputation in this population. Other genes and loci have been identified in linkage studies and GWAS, such as the COL4A3 gene or a region on chromosome 3q with the adiponectin gene. Replication was not always attempted and was rarely achieved, even for GWAS. Overall, effect sizes remain modest and no major gene has been identified, despite the strength of the genetic effect in transmission studies. We searched bibliographic databases for studies reporting genomic variants associated with diabetic nephropathy and meta-analyses of such studies. We selected important relevant studies for further discussion in this narrative review. This brief review attempts to summarise the current knowledge on the genetics of diabetic nephropathy and associated cardiovascular disease in people with type 1 diabetes, and discusses some conceptual and methodological issues relevant to the interpretation of past studies and the design of future ones.",
+ "PMID": "39575893",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Toward a cure for diabetes: iPSC and ESC-derived islet cell transplantation trials.",
+ "Abstract": "Advancements in regenerative medicine, particularly through the use of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), are garnering substantial attention as potential solutions to the limited availability of donors, leading to prolonged waiting periods for people with type 1 diabetes who require transplantation of pancreatic islets from deceased donors. The promising outcomes from recent clinical trials suggest that transplantation of iPSC- or ESC-derived islet cells could pave the way for more effective and broadly accessible treatment options. This progress holds potential not only for individuals with type 1 diabetes but may also extend to type 2 diabetes treatment in the future.",
"Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Genetic Predisposition to Disease",
- "Diabetic Nephropathies",
+ "Induced Pluripotent Stem Cells",
+ "Islets of Langerhans Transplantation",
+ "Clinical Trials as Topic",
"Diabetes Mellitus, Type 1",
- "Peptidyl-Dipeptidase A",
- "Cardiovascular Diseases",
- "Phenotype",
- "Genome-Wide Association Study",
- "Risk Factors",
- "Polymorphism, Genetic"
- ]
+ "Embryonic Stem Cells",
+ "Diabetes Mellitus, Type 2",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "22"
+ }
},
{
- "PMID": "39708266",
- "Title": "Genes & genomics",
- "ArticleTitle": "Baihu Jia Renshen Decoction may improve skeletal muscle and adipose tissue functions of type I diabetic rats by affecting pancreatic \u03b2-cell function.",
- "Abstract": "BJRD may influence pancreatic \u03b2-cell function, thereby enhancing the function of the skeletal muscle and adipose tissues in a T1DM rat model.",
+ "PMID": "39567321",
+ "Title": "Endocrinologia, diabetes y nutricion",
+ "ArticleTitle": "Automated insulin delivery systems in the treatment of diabetes: Benefits, challenges, and practical considerations in pediatric patients.",
+ "Abstract": "At present, the majority of patients with type 1 diabetes mellitus do not achieve the recommended glycemic control goals to reduce the risk of acute and chronic complications. Hybrid closed-loop systems or automated insulin infusion systems emerged as an opportunity to improve metabolic control, quality of life and reduce the psychosocial impact of type 1 diabetes. This article analyzes the evidence regarding their effectiveness and safety, the challenges they pose and best practices to optimize results when implemented in clinical practice.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Animals",
- "Rats",
- "Muscle, Skeletal",
- "Drugs, Chinese Herbal",
- "Insulin-Secreting Cells",
- "Male",
- "Adipose Tissue",
+ "Humans",
+ "Insulin Infusion Systems",
"Diabetes Mellitus, Type 1",
- "Diabetes Mellitus, Experimental",
- "Rats, Sprague-Dawley"
- ]
+ "Child",
+ "Insulin",
+ "Hypoglycemic Agents",
+ "Adolescent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39707866",
- "Title": "Endocrinology, diabetes & metabolism",
- "ArticleTitle": "Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study.",
- "Abstract": "This first exploratory study in people with T1D supports the potential utility of MPR as a screening tool for subclinical neurocognitive alterations in this population.",
+ "PMID": "39564761",
+ "Title": "Journal of diabetes science and technology",
+ "ArticleTitle": "Diabetes Technology Use in Special Populations: A Narrative Review of Psychosocial Factors.",
+ "Abstract": "As diabetes technologies continue to advance, their use is expanding beyond type 1 diabetes to include populations with type 2 diabetes, older adults, pregnant individuals, those with psychiatric conditions, and hospitalized patients. This review examines the psychosocial outcomes of these technologies across these diverse groups, with a focus on treatment satisfaction, quality of life, and self-management behaviors. Despite demonstrated benefits in glycemic outcomes, the adoption and sustained use of these technologies face unique challenges in each population. By highlighting existing research and identifying gaps, this review seeks to emphasize the need for targeted studies and tailored support strategies to understand and optimize psychosocial outcomes and well-being.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Pilot Projects",
- "Diabetes Mellitus, Type 1",
"Female",
- "Male",
- "Middle Aged",
- "Cognitive Dysfunction",
+ "Diabetes Mellitus, Type 2",
+ "Quality of Life",
+ "Pregnancy",
+ "Self-Management",
+ "Insulin Infusion Systems",
+ "Patient Satisfaction",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose Self-Monitoring",
"Adult",
- "Early Diagnosis",
"Aged",
- "Retina",
- "Visual Field Tests",
- "Diabetic Retinopathy",
- "Fixation, Ocular",
- "Neuropsychological Tests"
- ]
+ "Mental Disorders",
+ "Pregnancy in Diabetics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39707182",
- "Title": "Molecular medicine (Cambridge, Mass.)",
- "ArticleTitle": "Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables.",
- "Abstract": "These findings underscore significant metabolic disturbances in severe DKA and their associations with critical clinical indicators. Future investigations should explore if metabolic alterations in severe DKA can identify patients at increased risk of complications and/or guide future therapeutic interventions.",
+ "PMID": "39563039",
+ "Title": "Zhonghua er ke za zhi = Chinese journal of pediatrics",
+ "ArticleTitle": "[Guideline for the management of diabetic ketoacidosis in children (2024)].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Humans",
"Diabetic Ketoacidosis",
- "Male",
- "Female",
+ "Humans",
"Child",
- "Metabolomics",
- "Adolescent",
- "Metabolome",
- "Case-Control Studies",
"Diabetes Mellitus, Type 1",
- "Biomarkers",
- "Metabolic Networks and Pathways",
- "Machine Learning"
- ]
+ "China",
+ "Insulin",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39706675",
- "Title": "BMJ open diabetes research & care",
- "ArticleTitle": "Retrospective derivation of a causal pathway for diabetic ketoacidosis in adult patients with type 2 diabetes mellitus.",
- "Abstract": "in Detroit, MI, prior ketosis and private or Medicare health insurance were significantly associated with new or recurrent DKA in T2KPDM. Medication non-adherence had a mediating role.",
+ "PMID": "39556808",
+ "Title": "Diabetes",
+ "ArticleTitle": "Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes.",
+ "Abstract": "Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Diabetic Ketoacidosis",
- "Male",
- "Retrospective Studies",
- "Female",
- "Diabetes Mellitus, Type 2",
- "Middle Aged",
- "Adult",
- "Aged",
"Diabetes Mellitus, Type 1",
- "Blood Glucose",
- "Hypoglycemic Agents",
- "Risk Factors",
- "Assessment of Medication Adherence"
- ]
+ "C-Peptide",
+ "Genome-Wide Association Study",
+ "Genetic Predisposition to Disease",
+ "Age of Onset",
+ "Child",
+ "Alleles",
+ "HLA Antigens",
+ "Haplotypes",
+ "Female",
+ "Adolescent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39706641",
- "Title": "Journal of pharmacological sciences",
- "ArticleTitle": "Okanin alleviates symptoms of nociceptive-like responses in diabetic peripheral neuropathy in type 1 diabetic Wistar rats by regulating the AGEs/NF-\u03baB/Nrf-2 pathway.",
- "Abstract": "Elevated reactive species and AGEs contribute to deregulation of transcription factors e.g., NF-\u03baB and Nrf2 in diabetic peripheral neuropathy (DPN). Okanin, a bioactive chalcone, is active against redox imbalance, immune response, and pro-inflammatory events. The current investigation assessed effects of okanin in streptozotocin-induced DPN in rats. Wistar rats were divided into 6 groups (n\u00a0=\u00a06): Control, DPN, Okanin 2.5, Okanin 5, Okanin 10, and Gpn (Gabapentin). After 6 weeks of streptozotocin (55\u00a0mg/kg) injection, okanin (2.5, 5, 10\u00a0mg/kg), and gabapentin (50\u00a0mg/kg), were administered for 4 weeks. The streptozotocin-induced reduction in body weight, and increased feed/water intake, insulin, glucose, and HbA1c levels were mitigated by okanin or gabapentin. In DPN rats, Okanin or gabapentin ameliorated insulin resistance and \u03b2-cell function, inflammatory indices, and oxidative stress in the sciatic nerve of rodents thereby culminating in a decrease in hyperalgesia and allodynia. Okanin and streptozotocin-treated rats had significantly declined levels of AGEs, the receptor for AGEs, and NF-\u03baB, and an upsurge in Nrf2 expression. In streptozotocin-induced DPN model, okanin ameliorates nociceptive-like responses by regulating the AGEs/NF-\u03baB/Nrf2 pathway, suggesting that okanin has therapeutic value against DPN which needs further studies involving human subjects.",
+ "PMID": "39552173",
+ "Title": "Nursing children and young people",
+ "ArticleTitle": "Exploring homeostasis in children, the body's dynamic balancing act.",
+ "Abstract": "Homeostasis can be described as the dynamic process within an organism designed to maintain a relatively constant internal environment that is conducive to the optimal functioning of cells, enzymes and organs. To regulate physiological variables, homeostasis relies on mechanisms called negative and positive feedback loops. However, certain factors can disrupt homeostatic processes, leading to dysregulation and disease. This article provides an overview of homeostasis, including negative and positive feedback loops and dysregulation. The authors use a fictional case study - an adolescent girl with type 1 diabetes who develops diabetic ketoacidosis - to illustrate the adverse effects of homeostatic dysregulation and demonstrate the relevance of understanding homeostasis in children's nursing.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Animals",
- "Rats, Wistar",
- "Diabetic Neuropathies",
- "NF-kappa B",
- "Male",
- "Diabetes Mellitus, Experimental",
- "NF-E2-Related Factor 2",
+ "Humans",
+ "Homeostasis",
+ "Adolescent",
+ "Female",
"Diabetes Mellitus, Type 1",
- "Streptozocin",
- "Gabapentin",
- "Glycation End Products, Advanced",
- "Signal Transduction",
- "Rats",
- "Oxidative Stress",
- "Disease Models, Animal"
- ]
+ "Diabetic Ketoacidosis",
+ "Child"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "18"
+ }
},
{
- "PMID": "39706517",
- "Title": "Neuroscience",
- "ArticleTitle": "Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain.",
- "Abstract": "This study explored surface brain morphometry in type 1 diabetes including focus on painful diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with diabetes (18 without DPN, 19 with painless DPN, 19 with painful DPN) and 20 healthy controls. Cortical thickness, sulcus depth, and gyrification were analysed globally and regionally in each group and in the combined diabetes group. Associations with clinical characteristics and pain were assessed. Globally, cortical thickness was reduced in the combined diabetes group and in painful DPN compared to healthy controls. No differences in sulcus depth and gyrification were found. Several regions, including the middle frontal gyrus showed reduced cortical thickness in the combined diabetes- and painful DPN group. The postcentral gyrus exhibited reduced cortical thickness in painful DPN compared to healthy controls, and reduced sulcus depth compared to painless DPN correlating with higher pain intensity. Cortical thinning manifested across the brain cortex in diabetes, especially for painful DPN. Altered postcentral gyrus morphometry may be associated with neuropathic pain. Assessing cortical morphometry may be critical for comprehending central neuropathy and the manifestation of painful DPN in diabetes.",
+ "PMID": "39533790",
+ "Title": "Lakartidningen",
+ "ArticleTitle": "[Glycogenic hepatopathy/hepatic glycogenosis: an underappreciated but benign and reversible diabetic complication].",
+ "Abstract": "Almost 100 years ago, the French physician Pierre Mauriac described a syndrome named after him, resulting from poorly controlled type 1 diabetes, with growth retardation, delayed puberty, Cushingoid features and hepatomegaly. With modern diabetes care, this is very rare but does occur; however, despite the condition having important clinical implications and being easily treatable, this diabetes complication remains relatively unknown. We present here an authentic patient case in the form of a young man with glycemically poorly controlled type 1 diabetes who developed hepatomegaly, hyperlactatemia and histopathological changes in the liver consistent with glycogenosis, a state readily reversed by normalization of glycemia.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 1",
"Male",
- "Female",
- "Magnetic Resonance Imaging",
+ "Diabetes Mellitus, Type 1",
+ "Glycogen Storage Disease",
+ "Hepatomegaly",
+ "Liver",
+ "Liver Diseases",
"Adult",
- "Neuralgia",
- "Diabetic Neuropathies",
- "Middle Aged",
- "Brain",
- "Cerebral Cortex"
- ]
+ "Hyperlactatemia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39704278",
- "Title": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
- "ArticleTitle": "Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors.",
- "Abstract": "Numerous studies have reported altered cytokine levels in type 1 diabetes (T1D) patients, yet findings remain inconsistent. In this pilot study, we tested the hypothesis that circulating immune markers exhibit sex-based differences in T1D, both prior to and after disease onset. We analyzed 47-48 cytokine, chemokine, and growth factor levels in two cohorts. To assess post-disease differences, we analyzed serum samples from 25 controls and 25 T1D patients. To examine pre-disease progression, we utilized samples from 21 control children and 16 T1D progressors, collected at age 5\u2009years before disease onset. Across all T1D patients and controls, only macrophage colony-stimulating factor and interleukin (IL)-6 showed significant differences. However, we identified notable alterations when comparing sex-age-matched controls and T1D samples. Female T1D patients exhibited lower levels of inflammatory cytokines (tumor necrosis factor-\u03b1, IL-6, IL-1a), Th2 cytokines (IL-4, IL-13), and chemokines (macrophage inflammatory protein (MIP)-1\u03b1, regulated upon activation, normal T cell expressed and secreted, MIP-3) compared to female controls, differences that were not observed in males. Notably, IL-22 was lower in female T1D patients compared to female controls, whereas it was higher in male T1D patients compared to male controls. Male T1D patients showed elevated levels of growth factors (epidermal growth factor, platelet-derived growth factor-AB/BB) compared to male controls. In T1D progressors, growth-regulated alpha was lower compared to controls in both sexes. Multiple regression analysis further revealed associations between cytokine levels and factors such as age, BMI, and breastfeeding duration. Overall, our findings serve as a proof of concept, highlighting the importance of sex-specific differences in T1D pathogenesis. However, follow-up studies with larger sample sizes are needed to validate and generalize these results.",
+ "PMID": "39531505",
+ "Title": "Diabetes",
+ "ArticleTitle": "Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes.",
+ "Abstract": "There is variability in early-onset autoimmune diabetes presentation in individuals with monogenic autoimmunity; the mechanism(s) underlying this is unclear. We examined whether type 1 diabetes (T1D) polygenic risk contributes to clinical phenotype in monogenic autoimmune diabetes. Individuals with monogenic autoimmune diabetes had higher T1D genetic risk scores compared with control cohorts, driven largely by increased presence of T1D-risk DR3-DQ2 haplotype. Established T1D polygenic risk alleles, particularly class II HLA genes, contribute to clinical presentation in monogenic autoimmunity.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Diabetes Mellitus, Type 1",
"Humans",
+ "Genetic Predisposition to Disease",
+ "Phenotype",
"Female",
"Male",
- "Cytokines",
- "Diabetes Mellitus, Type 1",
+ "HLA-DQ Antigens",
+ "Haplotypes",
"Child",
- "Chemokines",
+ "Alleles",
"Adolescent",
- "Sex Factors",
- "Disease Progression",
- "Child, Preschool",
- "Intercellular Signaling Peptides and Proteins",
- "Pilot Projects",
- "Biomarkers",
- "Sex Characteristics",
- "Case-Control Studies"
- ]
- },
- {
- "PMID": "39704171",
- "Title": "JCI insight",
- "ArticleTitle": "The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes.",
- "Abstract": "Deficits in IL-2 signaling can precipitate autoimmunity by altering the function and survival of FoxP3+ regulatory T cells (Tregs) while high concentrations of IL-2 fuel inflammatory responses. Recently, we showed that the non-beta IL-2 SYNTHORIN molecule SAR444336 (SAR'336) can bypass the induction of autoimmune and inflammatory responses by increasing its reliance on IL-2 receptor \u03b1 chain subunit (CD25) to provide a bona fide IL-2 signal selectively to Tregs, making it an attractive approach for the control of autoimmunity. In this report, we further demonstrate that SAR'336 can support non-beta IL-2 signaling in murine Tregs and limit NK and CD8+ T cells' proliferation and function. Using a murine model of spontaneous type 1 diabetes, we showed that the administration of SAR'336 slows the development of disease in mice by decreasing the degree of insulitis through the expansion of antigen-specific Tregs over Th1 cells in pancreatic islets. Specifically, SAR'336 promoted the differentiation of IL-33-responsive (ST2+), IL-10-producing GATA3+ Tregs over other Treg subsets in the pancreas, demonstrating the ability of this molecule to further orchestrate Treg adaptation. These results offer insight into the capacity of SAR'336 to generate highly specialized, tissue-localized Tregs that promote restoration of homeostasis during ongoing autoimmune disease.",
- "Predictions": [
- "Diabetes type 1"
+ "HLA-DR3 Antigen"
],
- "MeshTerms": [
- "Animals",
- "T-Lymphocytes, Regulatory",
- "Diabetes Mellitus, Type 1",
- "Mice",
- "Interleukin-2",
- "Disease Models, Animal",
- "Interleukin-2 Receptor alpha Subunit",
- "Interleukin-1 Receptor-Like 1 Protein",
- "Interleukin-33",
- "Mice, Inbred NOD",
- "Female",
- "Signal Transduction",
- "CD8-Positive T-Lymphocytes",
- "Islets of Langerhans",
- "Th1 Cells",
- "Interleukin-10",
- "Autoimmunity",
- "Recombinant Proteins"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39704022",
- "Title": "Annals of medicine",
- "ArticleTitle": "Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints.",
- "Abstract": "Insulin dependency arises from autoimmunity that targets the \u03b2 cells of the pancreas, resulting in Type 1 diabetes (T1D). Despite the fact that T1D patients require insulin for survival, insulin does not provide a cure for this disease or prevent its complications. Despite extensive genetic, molecular, and cellular research on T1D over the years, the translation of this understanding into effective clinical therapies continues to pose a significant obstacle. It is therefore difficult to develop effective clinical treatment strategies without a thorough understanding of disease pathophysiology. Pancreatic tissue bioengineering models of human T1D offer a valuable approach to examining and controlling islet function while tackling various facets of the condition. And in recent years, due to advances in high-throughput omics analysis, the genotypic and molecular profiles of T1D have become finer tuned. The present article will examine recent progress in these areas, along with their utilization and constraints in the realm of T1D.",
+ "PMID": "39516020",
+ "Title": "Casopis lekaru ceskych",
+ "ArticleTitle": "Automated insulin delivery systems - settings in specific situations.",
+ "Abstract": "Automated insulin delivery systems (AID) represent a major advance in the treatment of type 1 diabetes. These systems automate insulin delivery by integrating continuous glucose monitoring, control algorithms and insulin pump actions. Despite their advances, there is a need to adjust the settings in specific situations, either by using special features or even by manually adjusting the dose. The article provides an overview of the possibilities of adjustments in the insulin dosing for intercurrent disease, alcohol consumption and increased physical activity for four certified automatic insulin delivery systems available in the Czech Republic.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 1",
- "Bioengineering",
- "Animals",
- "Genomics",
- "Insulin-Secreting Cells",
- "Proteomics",
+ "Insulin Infusion Systems",
"Insulin",
- "Islets of Langerhans"
- ]
- },
- {
- "PMID": "39703896",
- "Title": "Journal of nutritional science",
- "ArticleTitle": "The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.",
- "Abstract": "Polymorphisms in the vitamin D receptor (VDR) gene (BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236)) and low vitamin D concentrations have previously been associated with type 1 diabetes (T1D). Vitamin D is thought to mediate the switch from a pro-inflammatory Th1 response to an anti-inflammatory Th2 response which is protective against the development of T1D. These associations are inconsistent across studies and population groups. These associations have not been investigated in the South African black population. Thus, this observational, case-control study aims to address this knowledge gap. South African black participants with T1D (cases; n = 182) and healthy controls (n = 151) were genotyped for the four VDR polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Vitamin D levels were measured using high performance liquid chromatography (HPLC). Vitamin D levels were not significantly different between cases and controls (62.8 \u00b1 20.7 vs. 59.5 \u00b1 17.0 nmol/l, respectively; P = 0.122). Higher vitamin D levels were associated with the TaqI TT (P = 0.045) and FokI TT/TC (P = 0.014) genotypes in multivariate analyses. Furthermore, the TaqI TT genotype was associated with T1D status in multivariate analysis (P = 0.040). The FokI CC genotype increases the transcription of ",
- "Predictions": [
- "Diabetes type 1"
- ],
- "MeshTerms": [
- "Humans",
- "Receptors, Calcitriol",
- "South Africa",
"Diabetes Mellitus, Type 1",
- "Male",
- "Female",
- "Black People",
- "Adult",
- "Case-Control Studies",
- "Vitamin D",
- "Genotype",
- "Young Adult",
- "Polymorphism, Restriction Fragment Length",
- "Polymorphism, Single Nucleotide",
- "Genetic Predisposition to Disease",
- "Middle Aged",
- "Adolescent"
- ]
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39703609",
- "Title": "The Yale journal of biology and medicine",
- "ArticleTitle": "Pathological Sequelae of SARS-CoV-2: A Review for Clinicians.",
- "Abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic, driven by the novel coronavirus and its variants, has caused over 518 million infections and 6.25 million deaths globally, leading to a significant health crisis. Beyond its primary respiratory impact, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been implicated in various extra-pulmonary complications. Research studies reveal that the virus affects multiple organs, including the kidneys, liver, pancreas, and central nervous system (CNS), largely due to the widespread expression of Angiotensin Converting Enzyme-2 (ACE-2) receptors. Clinical evidence shows that the virus can induce diabetes by disrupting pancreatic and liver functions as well as cause acute kidney injury. Additionally, neurological complications, including cognitive impairments and neuroinflammation, have been observed in a significant number of COVID-19 patients. This review discusses the mechanisms linking SARS-CoV-2 to acute kidney injury, Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM), emphasizing its effects on pancreatic beta cells, insulin resistance, and the regulation of gluconeogenesis. We also explore how SARS-CoV-2 induces neurological complications, detailing the intricate pathways of neuro-invasion and the potential to trigger conditions such as Alzheimer's disease (AD). By elucidating the metabolic and neurological manifestations of COVID-19 and the underlying pathogenic mechanisms, this review underscores the imperative for continued research and the development of effective therapeutic interventions to mitigate the long-term and short-term impacts of SARS-CoV-2 infection.",
+ "PMID": "39514949",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Real-life evaluation of consensus recommendations for transition to subcutaneous insulin in hyperosmolar hyperglycemic crises.",
+ "Abstract": "A recent consensus report on hyperglycemic crises included recommendations for calculating the subcutaneous insulin dose when transitioning from intravenous insulin. In 95 patients admitted for hyperosmolar hyperglycemic crisis, there were no significant differences in post-transition glycemic control between patients who met the consensus recommendations and those who did not.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "SARS-CoV-2",
- "Acute Kidney Injury",
- "Diabetes Mellitus, Type 2",
- "Diabetes Mellitus, Type 1"
- ]
+ "Insulin",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Injections, Subcutaneous",
+ "Consensus",
+ "Hypoglycemic Agents",
+ "Practice Guidelines as Topic",
+ "Hyperglycemic Hyperosmolar Nonketotic Coma",
+ "Aged",
+ "Hyperglycemia",
+ "Adult",
+ "Retrospective Studies",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39702941",
- "Title": "Clinical and translational medicine",
- "ArticleTitle": "LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.",
- "Abstract": "LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induced immuno-resistant phenotype to pro-inflammatory macrophages. Mature dendritic cells acquire a tolerogenic phenotype via LRH-1/NR5A2-stimulated mitochondria turnover. LRH-1/NR5A2 agonistic activation expands a CD4",
+ "PMID": "39509638",
+ "Title": "Problemy endokrinologii",
+ "ArticleTitle": "[The use of TruCare III insulin pump in patients with type 1 diabetes mellitus].",
+ "Abstract": "The development of devices for continuous subcutaneous insulin infusion (CSII or insulin pumps) dramatically improved medical care for patients with diabetes mellitus. Insulin pump production widens annually resulting in number of new models entering the market, that differs in price but are similar in technical features. The entering of such new models to the Russian market can cause practical issues both in patient and in health care provider, so their estimation is of great importance. Insulin pump TruCare III (Apex Medical Co., Ltd, China) was registered in Russian Federation in September 15, 2023. The clinical experience of the TruCare III use in patients with type 1 diabetes mellitus is presented with the focus on glycemic parameters and custom features.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Diabetes Mellitus, Type 1",
- "Dendritic Cells",
"Humans",
- "Macrophages",
- "Immune Tolerance",
- "Receptors, Cytoplasmic and Nuclear",
- "Mitochondria",
+ "Insulin Infusion Systems",
+ "Insulin",
"Male",
"Female",
- "Phenotype"
- ]
+ "Adult",
+ "Blood Glucose",
+ "Hypoglycemic Agents",
+ "Middle Aged",
+ "Russia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39701114",
- "Title": "The lancet. Diabetes & endocrinology",
- "ArticleTitle": "Hybrid closed-loop insulin therapy and risk of severe hypoglycaemia and diabetic ketoacidosis in young people (aged 2-20 years) with type 1 diabetes: a population-based study.",
- "Abstract": "German Center for Diabetes Research, German Diabetes Society, and Robert Koch Institute.",
+ "PMID": "39423463",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes.",
+ "Abstract": "In a cohort of 2303 children with type 1 diabetes (T1D), we found that non-English speaking status (HR 2.82, 95% CI 1.54-5.18) and public insurance (HR 1.48, 95% CI 1.07-2.05) were associated with an increased risk of incident albuminuria, after adjusting for T1D-related variables (age, hemoglobin A1c, diabetic ketoacidosis episodes with acute kidney injury).",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Diabetic Ketoacidosis",
- "Adolescent",
+ "Albuminuria",
"Female",
"Male",
"Child",
- "Hypoglycemia",
- "Young Adult",
- "Insulin",
- "Hypoglycemic Agents",
- "Insulin Infusion Systems",
+ "Social Determinants of Health",
+ "Diabetic Nephropathies",
+ "Adolescent",
+ "Risk Factors",
+ "Cohort Studies",
"Child, Preschool",
- "Blood Glucose",
- "Prospective Studies",
- "Cohort Studies"
- ]
+ "Incidence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "18"
+ }
},
{
- "PMID": "39699995",
- "Title": "Diabetes care",
- "ArticleTitle": "Limitations in Achieving Glycemic Targets From CGM Data and Persistence of Severe Hypoglycemia in Adults With Type 1 Diabetes Regardless of Insulin Delivery Method.",
- "Abstract": "Despite use of diabetes technologies, many individuals are unable to achieve glycemic targets and experience severe hypoglycemia, highlighting the need for novel treatments.",
+ "PMID": "39368824",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The future of diabetes treatment].",
+ "Abstract": "Numerous therapeutic advances in the management of diabetes have been made in recent years, leading to the 2023 update of the Soci\u00e9t\u00e9 francophone du diab\u00e8te's position paper. These new treatments, for both autoimmune type 1 and type 2 diabetes, will continue to develop, offering patients personalized care.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Forecasting",
+ "Diabetes Mellitus, Type 2",
"Diabetes Mellitus, Type 1",
- "Hypoglycemia",
- "Adult",
- "Female",
- "Male",
- "Insulin",
- "Middle Aged",
- "Blood Glucose",
- "Blood Glucose Self-Monitoring",
- "Insulin Infusion Systems",
- "Hypoglycemic Agents",
- "Retrospective Studies",
- "Glycemic Control"
- ]
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39697323",
- "Title": "Frontiers in immunology",
- "ArticleTitle": "A novel microRNA promotes coxsackievirus B4 infection of pancreatic \u03b2 cells.",
- "Abstract": "The epidemiological association of coxsackievirus B infection with type 1 diabetes suggests that therapeutic strategies that reduce viral load could delay or prevent disease onset. Moreover, recent studies suggest that treatment with antiviral agents against coxsackievirus B may help preserve insulin levels in type 1 diabetic patients. In the current study, we performed small RNA-sequencing to show that infection of immortalized trophoblast cells with coxsackievirus caused differential regulation of several miRNAs. One of these, hsa-miR-AMC1, was similarly upregulated in human pancreatic \u03b2 cells infected with coxsackievirus B4. Moreover, treatment of \u03b2 cells with non-cytotoxic concentrations of an antagomir that targets hsa-miR-AMC1 led to decreased CVB4 infection, suggesting a positive feedback loop wherein this microRNA further promotes viral infection. Interestingly, some predicted target genes of hsa-miR-AMC1 are shared with hsa-miR-184, a microRNA that is known to suppress genes that regulate insulin production in pancreatic \u03b2 cells. Consistently, treatment of coxsackievirus B4-infected \u03b2 cells with the hsa-miR-AMC1 antagomir was associated with a trend toward increased insulin production. Taken together, our findings implicate novel hsa-miR-AMC1 as a potential early biomarker of coxsackievirus B4-induced type 1 diabetes and suggest that inhibiting hsa-miR-AMC1 may provide therapeutic benefit to type 1 diabetes patients. Our findings also support the use of trophoblast cells as a model for identifying microRNAs that might be useful diagnostic markers or therapeutic targets for coxsackievirus B-induced type 1 diabetes.",
+ "PMID": "39368821",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The contribution of social networks using the example of type 1 diabetes].",
+ "Abstract": "Type 1 diabetes has an impact not only on physical health, but also on social life, family life and psychological balance. Social networks play a decisive role, alongside associations, in helping patients to adopt the \"other pace of life\" implied by the disease. Beyond health, the skills needed to enable patients to achieve personal fulfillment are beyond the scope of healthcare professionals. Peer communities are an invaluable contribution to building this life with diabetes.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "MicroRNAs",
- "Insulin-Secreting Cells",
- "Enterovirus B, Human",
- "Coxsackievirus Infections",
"Diabetes Mellitus, Type 1",
- "Cell Line",
- "Insulin",
- "Trophoblasts"
- ]
+ "Social Support",
+ "Social Networking"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39696373",
- "Title": "BMC medical informatics and decision making",
- "ArticleTitle": "A prior-knowledge-guided dynamic attention mechanism to predict nocturnal hypoglycemic events in type 1 diabetes.",
- "Abstract": "Nocturnal hypoglycemia is a critical problem faced by diabetic patients. Failure to intervene in time can be dangerous for patients. The existing early warning methods struggle to extract crucial information comprehensively from complex multi-source heterogeneous data. In this paper, a deep learning framework with an innovative dynamic attention mechanism is proposed to predict nocturnal hypoglycemic events for type 1 diabetes patients. Features related to nocturnal hypoglycemia are extracted from multi-scale and multi-dimensional data, which enables comprehensive information extraction from diverse sources. Then, we propose a prior-knowledge-guided attention mechanism to enhance the network's learning capability and interpretability. The method was evaluated on a public available clinical dataset, which successfully warned 94.91% of nocturnal hypoglycemic events with an F1-score of 96.35%. By integrating our proposed framework into the nocturnal hypoglycemia early warning model, issues related to feature redundancy and incompleteness were mitigated. Comparative analysis demonstrates that our method outperforms existing approaches, offering superior accuracy and practicality in real-world scenarios.",
+ "PMID": "39368816",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The transition to the adult diabetes service: step-by-step support].",
+ "Abstract": "The transition of young type 1 diabetic patients from pediatrics to adult diabetes services is a delicate stage, with the risk of a break in the care pathway. These adolescents are apprehensive about leaving the pediatric sector, and often experience the change as an abandonment. It is therefore vital to prepare them and support them during and after the transfer, in order to improve their experience.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Transition to Adult Care",
"Diabetes Mellitus, Type 1",
- "Hypoglycemia",
- "Deep Learning"
- ]
+ "Adolescent",
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39696094",
- "Title": "BMC pediatrics",
- "ArticleTitle": "Sirolimus alleviated intractable diarrhea of IPEX syndrome: a case report and literature review.",
- "Abstract": "We reviewed the literature on the use of sirolimus for the treatment of IPEX syndrome over the past two decades.",
+ "PMID": "39368490",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "A proposal for breakfast to improve the postprandial glucose response in children with type 1 diabetes - Preliminary results from a camp-based study.",
+ "Abstract": "This study aimed to evaluate post - prandial glucose response (PPGR) after a traditional Italian breakfast and an alternative meal in children with type 1 diabetes (T1D). Preliminary findings showed that by replacing a small portion ofcarbohydrates with fats helpsimprovingPPGR after breakfast in children with T1D.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Diabetes Mellitus, Type 1",
+ "Postprandial Period",
+ "Child",
+ "Blood Glucose",
"Male",
- "Sirolimus",
- "Genetic Diseases, X-Linked",
- "Diarrhea",
- "Immunosuppressive Agents",
- "Forkhead Transcription Factors",
- "Immune System Diseases",
- "Infant",
- "Mutation",
- "Diabetes Mellitus, Type 1"
- ]
+ "Breakfast",
+ "Female",
+ "Adolescent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39692076",
- "Title": "Muscle & nerve",
- "ArticleTitle": "Validation of the Histamine- and Heat-Induced Axon-Reflex Flare Response in a Nonselected Population of People With Type 1 Diabetes.",
- "Abstract": "The histamine-induced ARF response is a valid marker for small fiber neuropathy even in nonselected populations with diabetes with good agreement with established markers and can thus be used for evaluation of C-fiber function. The lack of correlation with the heat-induced ARF may be due to insufficient heating.",
+ "PMID": "39365619",
+ "Title": "Folia medica",
+ "ArticleTitle": "Assessment of body composition of adult Bulgarian patients with type 1 diabetes mellitus by bioelectrical impedance analysis.",
+ "Abstract": "The aim of this study was to investigate how type 1 diabetes mellitus affects adult Bulgarians' body composition.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Male",
- "Histamine",
+ "Body Composition",
+ "Bulgaria",
"Female",
"Adult",
- "Hot Temperature",
+ "Male",
+ "Electric Impedance",
"Middle Aged",
- "Diabetic Neuropathies",
- "Axons",
- "Neural Conduction",
- "Reflex",
- "Sural Nerve",
- "Young Adult",
- "ROC Curve",
- "Neurologic Examination"
- ]
+ "Young Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39691822",
- "Title": "Journal of diabetes research",
- "ArticleTitle": "Characteristics of Children, Youth, and Young Adults With Diabetes: A Cross-Sectional Study in New Zealand Aotearoa.",
- "Abstract": {
- "b": "Conclusions",
- "i": "p"
- },
+ "PMID": "39363571",
+ "Title": "Lakartidningen",
+ "ArticleTitle": "[The diabetic hand - a forgotten complication].",
+ "Abstract": "The term \u00bbthe diabetic hand\u00ab traditionally denotes complications affecting the hand in individuals with diabetes mellitus, such as restricted finger movement, numbness, and pain. Trigger finger, Dupuytren's disease, carpal tunnel syndrome, ulnar nerve entrapment, and osteoarthritis of the first carpometacarpal joint are all conditions that are more prevalent among individuals with both type 1 and type 2 diabetes. This overview aims to shed light on a somewhat neglected area in diabetes complications, i.e. the diabetic hand, to increase the knowledge among physicians and surgeons as well as nurses, physiotherapists, and occupational therapists treating patients with diabetes.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
- "New Zealand",
- "Cross-Sectional Studies",
- "Adolescent",
- "Child",
- "Diabetes Mellitus, Type 1",
- "Young Adult",
+ "Carpal Tunnel Syndrome",
+ "Dupuytren Contracture",
+ "Diabetes Complications",
+ "Hand",
+ "Trigger Finger Disorder",
+ "Osteoarthritis",
+ "Diabetic Neuropathies",
"Diabetes Mellitus, Type 2",
- "Hypoglycemic Agents",
- "Prevalence",
- "Child, Preschool",
- "Adult",
- "Glycated Hemoglobin",
- "Primary Health Care"
- ]
+ "Diabetes Mellitus, Type 1"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39689816",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Men with type 1 diabetes had a more than 7-fold odds of elevated depressive symptoms compared to men without diabetes.",
- "Abstract": "Our results demonstrate that there is an urgent need to screen adults with T1D for depressive symptoms as part of routine medical care and to test interventions to minimize their impact on physical health outcomes.",
+ "PMID": "39327517",
+ "Title": "Nature",
+ "ArticleTitle": "Stem cells reverse woman's diabetes - a world first.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Adult",
+ "Animals",
+ "Female",
"Humans",
- "Male",
+ "Mice",
"Diabetes Mellitus, Type 1",
- "Female",
- "Middle Aged",
- "Depression",
- "Adult",
- "Glycated Hemoglobin",
- "Prevalence",
- "Sex Factors",
- "Surveys and Questionnaires",
- "Self-Management"
- ]
+ "Stem Cell Transplantation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "27"
+ }
},
{
- "PMID": "39689633",
- "Title": "Patient education and counseling",
- "ArticleTitle": "Understanding the parental journey: Exploring experiences, needs, and perceptions during hospitalization for children newly diagnosed with type 1 diabetes.",
- "Abstract": "The study sheds light on families' challenges during initial hospital-based diabetes education, offering insights for healthcare professionals to tailor support strategies and improve diabetes management.",
+ "PMID": "39322890",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Child",
"Humans",
"Diabetes Mellitus, Type 1",
- "Female",
- "Male",
- "Parents",
- "Qualitative Research",
- "Child",
- "Adolescent",
- "Child, Preschool",
- "Interviews as Topic",
- "Infant",
- "Hospitalization",
- "Adult",
- "Self Care",
- "Self-Management",
- "Perception",
- "Social Support"
- ]
+ "Diabetic Ketoacidosis",
+ "Germany",
+ "Socioeconomic Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "26"
+ }
},
{
- "PMID": "39688288",
- "Title": "Diabetes care",
- "ArticleTitle": "Project ECHO Diabetes Trial Improves Outcomes for Medically Underserved People.",
- "Abstract": "The ECHO model demonstrates promise for reducing health disparities in diabetes and contributes to our understanding of program benefits beyond the provider level.",
+ "PMID": "39322880",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Female",
- "Middle Aged",
- "Male",
- "Adult",
- "Diabetes Mellitus, Type 2",
- "Glycated Hemoglobin",
+ "Insulin Infusion Systems",
+ "Air Travel",
"Diabetes Mellitus, Type 1",
- "Medically Underserved Area",
- "California",
- "Florida"
- ]
- },
- {
- "PMID": "39686350",
- "Title": "Sensors (Basel, Switzerland)",
- "ArticleTitle": "Performance of a Non-Invasive System for Monitoring Blood Glucose Levels Based on Near-Infrared Spectroscopy Technology (",
- "Abstract": [
- "Overall, 105 subjects (mean age 53.8 \u00b1 13.8 years, 50.5% female) participated, resulting in 1914 paired glucose measurements between 49 and 331 mg/dL. Total mean absolute relative difference (MARD) was 20.3%, MARD for values >100 mg/dL was 18.3%, and mean absolute deviation (MAD) for values <100 mg/dL was 24.9%. A total of 97.3% of measurements fell within A+B Parkes zones, and 58.8%, 76.9%, and 88.1% within +-20%, +-30%, or +-40% error, respectively. On completion, 62 participants (59%) fulfilled the one-week prospective sub-study. In this subgroup, the total MARD was reduced between day 1 and day 8 from 22.8 to 18.3% (",
- {
- "i": "Glucube"
- }
- ],
- "Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Insulin",
+ "Hypoglycemic Agents"
],
- "MeshTerms": [
- "Humans",
- "Blood Glucose Self-Monitoring",
- "Female",
- "Spectroscopy, Near-Infrared",
- "Blood Glucose",
- "Male",
- "Middle Aged",
- "Prospective Studies",
- "Diabetes Mellitus, Type 2",
- "Adult",
- "Aged",
- "Diabetes Mellitus, Type 1"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "26"
+ }
},
{
- "PMID": "39686207",
- "Title": "Sensors (Basel, Switzerland)",
- "ArticleTitle": "Hybrid CNN-GRU Model for Real-Time Blood Glucose Forecasting: Enhancing IoT-Based Diabetes Management with AI.",
- "Abstract": "For people with diabetes, controlling blood glucose level (BGL) is a significant issue since the disease affects how the body metabolizes food, which makes careful insulin regulation necessary. Patients have to manually check their blood sugar levels, which can be laborious and inaccurate. Many variables affect BGL changes, making accurate prediction challenging. To anticipate BGL many steps ahead, we propose a novel hybrid deep learning model framework based on Gated Recurrent Units (GRUs) and Convolutional Neural Networks (CNNs), which can be integrated into the Internet of Things (IoT)-enabled diabetes management systems, improving prediction accuracy and timeliness by allowing real-time data processing on edge devices. While the GRU layer records temporal relationships and sequence information, the CNN layer analyzes the incoming data to extract significant features. Using a publicly accessible type 1 diabetes dataset, the hybrid model's performance is compared to that of the standalone Long Short-Term Memory (LSTM), CNN, and GRU models. The findings show that the hybrid CNN-GRU model performs better than the single models, indicating its potential to significantly improve real-time BGL forecasting in IoT-based diabetes management systems.",
+ "PMID": "39306455",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "The promise of once-weekly insulins for type 1 diabetes: update on progress.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Neural Networks, Computer",
- "Blood Glucose",
- "Internet of Things",
- "Deep Learning",
"Diabetes Mellitus, Type 1",
- "Blood Glucose Self-Monitoring",
- "Forecasting"
- ]
+ "Hypoglycemic Agents",
+ "Insulin",
+ "Drug Administration Schedule"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "22"
+ }
},
{
- "PMID": "39683492",
- "Title": "Nutrients",
- "ArticleTitle": "Metabolic and Hormonal Responses to Isomaltulose Ingestion Before or During Sustained Submaximal Exercise in Adults with Type 1 Diabetes Using Automated Insulin Delivery Systems.",
- "Abstract": "The consumption of smaller servings of isomaltulose during, rather than as a single isocaloric serving before, submaximal sustained exercise provided (i) a better glycemic protective effect, (ii) a lesser push on pancreatic and gut-mediated glucoregulatory hormones, and (iii) a lower reliance on whole-body carbohydrate oxidation. Such information serves to remind us of the potential importance of nutrition for modulating the metabolic fate of an acute bout of exercise and may help inform best practice guidelines for exercise management in the T1D-sphere.",
+ "PMID": "39302761",
+ "Title": "IEEE pulse",
+ "ArticleTitle": "Designing a Closed-Loop Automated Insulin Delivery System: Simplifying Life for People, Including Children, Living With Type 1 Diabetes.",
+ "Abstract": "Living with type 1 diabetes is challenging, especially for children and their caregivers. This article describes how Insulet, the global leader in tubeless insulin technology, has continuously innovated Omnipod, a discreet, wearable, waterproof insulin delivery system that simplifies life for people with diabetes.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Humans",
- "Isomaltose",
- "Female",
"Diabetes Mellitus, Type 1",
- "Male",
- "Middle Aged",
- "Cross-Over Studies",
- "Adult",
- "Exercise",
- "Insulin",
- "Blood Glucose",
+ "Humans",
"Insulin Infusion Systems",
- "Glucagon",
- "Glucagon-Like Peptide 1"
- ]
+ "Insulin",
+ "Child",
+ "Hypoglycemic Agents",
+ "Equipment Design",
+ "Wearable Electronic Devices"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "20"
+ }
},
{
- "PMID": "39683465",
- "Title": "Nutrients",
- "ArticleTitle": "Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management.",
- "Abstract": "Latent autoimmune diabetes of adults (LADA) is the most prevalent form of autoimmune diabetes (AI-D) in adulthood; however, its accurate diagnosis and optimal treatment remain challenging. Vitamin D deficiency (VDD) is commonly observed in LADA patients, while increased vitamin D exposure through supplementation and dietary intake is associated with a reduced incidence of LADA. Although limited, case reports, case-control studies, and randomized clinical trials have examined the effects of vitamin D supplementation-alone or combined with dipeptidyl peptidase-4 inhibitors (DPP4-is)-on glucose regulation, residual \u03b2-cell function, and glutamic acid decarboxylase antibody (GADA65) levels. Findings, while preliminary, indicate that vitamin D supplementation may enhance glycemic control, preserve \u03b2-cell function, and reduce autoimmune activity. Given its accessibility, affordability, and relative safety, vitamin D supplementation presents an attractive adjunct treatment option for LADA patients. This narrative review discusses current evidence on the potential therapeutic benefits of vitamin D supplementation in patients with AI-D, including LADA, who are also vitamin D deficient. Beginning with an exploration of the epidemiological patterns, clinical presentation, and diagnostic framework essential for understanding and identifying LADA, this review then examines the proposed mechanisms through which vitamin D may influence autoimmune modulation of pancreatic \u03b2-cells, integrating recent data pertinent to LADA pathology. By distilling and consolidating existing research, we aim to provide a platform for advancing targeted investigations within this distinct patient population.",
+ "PMID": "39289035",
+ "Title": "BMJ case reports",
+ "ArticleTitle": "Acrofacial dysmorphism and lipodystrophy: unveiling mandibuloacral dysplasia in a case of young onset diabetes mellitus.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Female",
"Humans",
+ "Lipodystrophy",
+ "Mandible",
+ "Male",
"Diabetes Mellitus, Type 1",
- "Dietary Supplements",
- "Dipeptidyl-Peptidase IV Inhibitors",
- "Insulin-Secreting Cells",
- "Latent Autoimmune Diabetes in Adults",
- "Vitamin D",
- "Vitamin D Deficiency"
- ]
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "18"
+ }
},
{
- "PMID": "39682744",
- "Title": "Cells",
- "ArticleTitle": "Beta-Cell-Derived Extracellular Vesicles: Mediators of Intercellular Communication in the Islet Microenvironment in Type 1 Diabetes.",
- "Abstract": "Type 1 diabetes (T1D) is a chronic autoimmune disorder characterised by an autoimmune response specifically mounted against the insulin-producing beta cells. Within the islet, high cellular connectivity and extensive vascularisation facilitate intra-islet communication and direct crosstalk with the surrounding tissues and the immune system. During the development of T1D, cytokines and extracellular vesicles released by beta cells can contribute to the recruitment of immune cells, further amplifying autoimmunity and aggravating beta cell damage and dysfunction. In this review, we will evaluate the role of beta-cell-derived extracellular vesicles as mediators of the autoimmune response and discuss their potential for early diagnosis and new therapeutic strategies in T1D.",
+ "PMID": "39266233",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Diabetes: Once weekly insulin could be as effective as daily injections, studies indicate.",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
- "Diabetes Mellitus, Type 1",
- "Extracellular Vesicles",
"Humans",
- "Insulin-Secreting Cells",
- "Cell Communication",
- "Animals",
- "Islets of Langerhans",
- "Cellular Microenvironment"
- ]
+ "Hypoglycemic Agents",
+ "Insulin",
+ "Drug Administration Schedule",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "13"
+ }
},
{
- "PMID": "39682729",
- "Title": "Cells",
- "ArticleTitle": "Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa.",
- "Abstract": "Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs-PTPN22, PTPN2, PTPN6, PTPN11, PTP\u03c3, DUSP2, DUSP6 and PTPRK-at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.",
+ "PMID": "39264558",
+ "Title": "Bulletin of experimental biology and medicine",
+ "ArticleTitle": "Dysmetabolism of Peripheral Blood Monocytes in Type 1 Diabetes Mellitus.",
+ "Abstract": "The level of ROS (fluorescent probe 2',7'-dichlorodihydrofluorescein diacetate) and lipid content (fluorescent lipophilic dye Nile Red) in the peripheral blood monocyte fraction from patients with type 1 diabetes mellitus and healthy volunteers were assessed by flow cytofluorimetry. The number of CD36 monocytes was assessed using specific antibodies. In patients with type 1 diabetes mellitus, the levels of ROS and intracellular lipids in monocytes and the number of cells expressing CD36 fatty acid translocase were elevated. These results indicate metabolic changes in the peripheral blood cells of patients with carbohydrate metabolism disorders and can be considered as possible prognostic markers for the development of type 1 diabetes mellitus complications.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Intestinal Mucosa",
- "Inflammatory Bowel Diseases",
- "Celiac Disease",
- "Protein Tyrosine Phosphatases",
- "Animals",
- "Diabetes Mellitus, Type 1"
- ]
+ "Diabetes Mellitus, Type 1",
+ "Monocytes",
+ "Male",
+ "Adult",
+ "Female",
+ "Reactive Oxygen Species",
+ "CD36 Antigens",
+ "Case-Control Studies",
+ "Flow Cytometry",
+ "Young Adult",
+ "Lipid Metabolism"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "12"
+ }
},
{
- "PMID": "39682726",
- "Title": "Cells",
- "ArticleTitle": "Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.",
- "Abstract": "Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer's disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissociated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain potential biological insights into the relevance of HSV-1-induced inflammation in AD and T1D. We observed that differentially expressed genes (DEGs) in HSV-1-infected sc-islets were enriched for genes associated with several autoimmune diseases, most significantly, T1D, but also rheumatoid arthritis, psoriasis, Crohn's disease, and multiple sclerosis, whereas DEGs in HSV-1-infected dcOrgs were exclusively enriched for genes associated with AD. The ACV treatment of sc-islets was not as effective in rescuing transcript perturbations of autoimmune disease-associated genes. Finally, we identified gene ontology categories that were enriched for DEGs that were in common across, or unique to, viral treatment of dcOrgs and sc-islets, such as categories involved in the transferase complex, mitochondrial, and autophagy function. In addition, we compared transcriptomic signatures from HSV-1-infected sc-islets with sc-islets that were infected with the coxsackie B virus (CVB) that had been associated with T1D pathogenesis. Collectively, this study provides tissue-specific insights into the molecular effects of inflammation in AD and T1D.",
+ "PMID": "39264509",
+ "Title": "Journal of clinical immunology",
+ "ArticleTitle": "HSCT in a Patient with Cernunnos/XLF Deficiency and Omenn Syndrome.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Organoids",
- "Alzheimer Disease",
- "Herpesvirus 1, Human",
- "Brain",
- "Herpes Simplex",
- "Islets of Langerhans",
- "Autoimmune Diseases",
- "Stem Cells",
- "Transcriptome",
- "Diabetes Mellitus, Type 1"
- ]
+ "Hematopoietic Stem Cell Transplantation",
+ "Severe Combined Immunodeficiency",
+ "Male",
+ "Genetic Diseases, X-Linked",
+ "Infant",
+ "Diabetes Mellitus, Type 1",
+ "Diarrhea",
+ "Immune System Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "12"
+ }
},
{
- "PMID": "39680874",
- "Title": "JMIR research protocols",
- "ArticleTitle": "Examining Share plus-A Continuous Glucose Monitoring Plus Data-Sharing Intervention in Older Adults and Their Care Partners: Protocol for a Randomized Control Study.",
- "Abstract": "DERR1-10.2196/60004.",
+ "PMID": "39264010",
+ "Title": "Journal of diabetes",
+ "ArticleTitle": "Continuous glucose monitor metrics and hemoglobin A1c correlation in youth with diabetes: A retrospective analysis of real-world correlations.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Glycated Hemoglobin",
+ "Retrospective Studies",
"Blood Glucose Self-Monitoring",
- "Aged",
- "Diabetes Mellitus, Type 1",
- "Caregivers",
+ "Blood Glucose",
+ "Adolescent",
"Male",
- "Pilot Projects",
"Female",
- "Feasibility Studies",
- "Quality of Life",
- "Middle Aged",
- "Self-Management",
- "Continuous Glucose Monitoring"
- ]
+ "Child",
+ "Diabetes Mellitus, Type 1",
+ "Glycemic Control"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "12"
+ }
},
{
- "PMID": "39680256",
- "Title": "Current diabetes reports",
- "ArticleTitle": "Parental Psychosocial Variables and Glycemic Control in T1D Pediatric Age: A Systematic Review.",
- "Abstract": "Type 1 Diabetes (T1D) in young children can be very complex to manage for their parents since they are the main individuals responsible for T1D tasks. Also, parental psychological adjustment impacts children's glycemic outcomes. This systematic review was performed following the PRISMA guidelines. The search process was conducted in four databases from 2019 to 2024. From a total of 215 studies, 5 were included. We identified five studies that found direct associations between parental psychosocial variables and children's glycemic outcomes. These findings suggest a unidirectional perspective, evidencing the need to examine the longitudinal interplay between these variables. In sum, promoting parental psychological interventions may be fundamental for enhancing children's glycemic outcomes.",
+ "PMID": "39257582",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle.",
+ "Abstract": "The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Glycemic Control",
- "Child",
"Diabetes Mellitus, Type 1",
- "Parents",
- "Child, Preschool",
- "Hypoglycemia",
- "Stress, Psychological",
- "Infant",
- "Blood Glucose",
- "Parent-Child Relations",
- "Fear"
- ]
+ "HIV Infections",
+ "Anti-Retroviral Agents",
+ "HIV-1",
+ "Anti-HIV Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "11"
+ }
},
{
- "PMID": "39679900",
- "Title": "Endocrinology, diabetes & metabolism",
- "ArticleTitle": "Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes.",
- "Abstract": "This study highlights the importance of metabolic health represented by insulin resistance in the development of diabetic complications and cardiovascular events in T1D beyond their weight status.",
+ "PMID": "39250919",
+ "Title": "The lancet. Diabetes & endocrinology",
+ "ArticleTitle": "Islet transplantation in kidney transplant recipients with type 1 diabetes.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Male",
- "Female",
- "Adult",
- "Obesity",
- "Diabetes Complications",
- "Insulin Resistance",
- "Young Adult",
- "Cardiovascular Diseases",
- "Obesity, Metabolically Benign",
- "Body Mass Index",
- "Follow-Up Studies",
- "Adolescent",
- "Diabetic Neuropathies"
- ]
+ "Kidney Transplantation",
+ "Islets of Langerhans Transplantation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "10"
+ }
},
{
- "PMID": "39678192",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Serum exocrine pancreas enzymes are biomarkers of immunotherapy response in new-onset type 1 diabetes.",
- "Abstract": "Our findings provide preliminary evidence that the exocrine pancreatic enzymes lipase and trypsin may be useful biomarkers of response to immunotherapy in type 1 diabetes. Further studies with larger numbers of participants are warranted.",
+ "PMID": "39239945",
+ "Title": "Internal medicine journal",
+ "ArticleTitle": "Resolution of symptoms of binge eating disorder associated with semaglutide treatment for obesity and type 1 diabetes.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Glucagon-Like Peptides",
"Diabetes Mellitus, Type 1",
- "Male",
- "Biomarkers",
+ "Obesity",
+ "Binge-Eating Disorder",
"Female",
- "Lipase",
+ "Hypoglycemic Agents",
"Adult",
- "Amylases",
- "Immunotherapy",
- "Trypsin",
- "Young Adult",
- "Pancreas, Exocrine",
- "Adolescent",
- "Granulocyte Colony-Stimulating Factor",
"Treatment Outcome",
+ "Male",
"Middle Aged"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "6"
+ }
},
{
- "PMID": "39676645",
- "Title": "Cardiology in the young",
- "ArticleTitle": "Influence of pre-existing maternal diabetes mellitus on fetal myocardial performance index and systolic-to-diastolic duration ratio: a prospective cohort study.",
- "Abstract": "Pre-existing maternal diabetes mellitus had significant influence on fetal left ventricle myocardial performance index, but no effect on systolic-to-diastolic duration ratio. Systolic-to-diastolic duration ratio was not useful in predicting adverse perinatal outcomes.",
+ "PMID": "39208831",
+ "Title": "The lancet. Diabetes & endocrinology",
+ "ArticleTitle": "Transitioning to stage 3 type 1 diabetes: when to start insulin.",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Female",
- "Pregnancy",
- "Prospective Studies",
- "Adult",
- "Systole",
- "Diastole",
- "Ultrasonography, Prenatal",
- "Fetal Heart",
"Diabetes Mellitus, Type 1",
- "Echocardiography, Doppler",
- "Young Adult",
- "Ventricular Function, Left",
- "Myocardial Contraction",
- "Pregnancy in Diabetics",
- "Stroke Volume",
- "Diabetes Mellitus, Type 2",
- "Heart Ventricles"
- ]
+ "Insulin",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39676515",
- "Title": "Current diabetes reviews",
- "ArticleTitle": "The Teachers' Knowledge of Type 1 Diabetes in Schools: An Interventional Study.",
- "Abstract": "Our study showed a lack of information about type 1 diabetes among teachers. We also proved the effectiveness of targeted education in correcting misconceptions and encouraging awareness of type 1 diabetes.",
+ "PMID": "39208437",
+ "Title": "Obstetrics and gynecology",
+ "ArticleTitle": "Integrated Strategies to Support Diabetes Technology in Pregnancy.",
+ "Abstract": "Managing diabetes in pregnancy can be overwhelming, with numerous dramatic physiologic changes taking place that require constant diligence and attention. Advances in diabetes technology have improved glycemic outcomes, well-being, and quality of life for people with type 1 diabetes of all ages. However, regulatory approval and access to diabetes technology in pregnancy has lagged behind these advancements, leaving many pregnant individuals without tools that could dramatically improve diabetes care before, during, and after gestation. Here, we review the benefits of continuous glucose monitors and automated insulin-delivery systems in pregnancy and highlight specific scientific and structural supports to help implement diabetes technology safely, effectively, and equitably in pregnancy.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Pregnancy",
+ "Female",
+ "Pregnancy in Diabetics",
"Diabetes Mellitus, Type 1",
- "Health Knowledge, Attitudes, Practice",
+ "Insulin Infusion Systems",
+ "Blood Glucose Self-Monitoring",
+ "Insulin",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39207742",
+ "Title": "JAMA",
+ "ArticleTitle": "Highs and Lows.",
+ "Abstract": "",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes, Gestational",
"Female",
- "Male",
- "School Teachers",
- "Morocco",
- "Adult",
- "Surveys and Questionnaires",
- "Child",
- "Schools",
- "Health Education",
- "School Health Services"
- ]
+ "Pregnancy",
+ "Diabetes Mellitus, Type 1",
+ "Depression, Postpartum",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39675543",
- "Title": "Chemico-biological interactions",
- "ArticleTitle": "Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice.",
- "Abstract": "The relationship between arsenic exposure and the development of diabetes mellitus has garnered significant interest in recent years. However, current experimental studies have not definitively established the role of arsenic in the onset of diabetes mellitus. To investigate this relationship specifically concerning type 1 diabetes mellitus, Streptozocin (STZ) was utilized as an inducer to initiate the fundamental pathological changes associated with the disease. A high dose of STZ (50\u00a0mg/kg) served as the positive control, while a low dose of STZ (20\u00a0mg/kg) was administered in combination with arsenic at varying doses. The objective was to determine whether arsenic enhances the effects of STZ, thereby leading to an expedited onset and progression of type 1 diabetes mellitus. The preliminary investigation into the impact of arsenic exposure on experimental type 1 diabetic mice focused on the NLRP3/Caspase-1/GSDMD mediated pyroptosis pathway. The results showed that fasting blood glucose (FBG) was increased, glucose tolerance was impaired, insulin sensitivity was decreased, fasting serum insulin and the homeostatic model assessment-\u03b2 (HOMA-\u03b2) were significantly reduced, hair arsenic content was increased, reactive oxygen species(ROS), interleukin (IL)-1\u03b2 and IL-18 contents were increased, and the pathological morphology of pancreas was more serious in the combined group. Moreover, the expression levels of proteins associated with the NLRP3/Caspase-1/GSDMD-mediated pyroptosis pathway were elevated in the combined group. This study illustrates that exposure to arsenic, combined with low-dose STZ, not only leads to pancreatic injury in mice, impacting insulin secretion and causing elevated blood glucose levels, thereby hastening the progression of type 1 diabetes, but also induces pyroptosis in pancreatic tissues by influencing the NLRP3/Caspase-1/GSDMD signaling pathway, further facilitating the development of type 1 diabetes.",
+ "PMID": "39192756",
+ "Title": "Journal of cellular physiology",
+ "ArticleTitle": "Mechanisms of insulin resistance in type 1 diabetes mellitus: A case of glucolipotoxicity in skeletal muscle.",
+ "Abstract": "Insulin resistance (IR), a hallmark of type 2 diabetes mellitus, develops in a significant number of patients with type 1 diabetes mellitus (T1DM) despite the use of insulin therapy to control glycemia. However, little is currently understood regarding the underlying mechanisms of IR in T1DM, especially within the context of chronic insulin treatment. Recent evidence suggests an important influence of glucolipotoxicity in skeletal muscle on insulin sensitivity in T1DM. Thus, this review summarizes our current knowledge regarding impairments in skeletal muscle lipid, glucose, and oxidative metabolism in the development of IR in insulin-treated T1DM.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Animals",
- "Pyroptosis",
+ "Humans",
+ "Insulin Resistance",
+ "Muscle, Skeletal",
"Diabetes Mellitus, Type 1",
- "Mice",
- "Arsenic",
- "Caspase 1",
- "NLR Family, Pyrin Domain-Containing 3 Protein",
- "Diabetes Mellitus, Experimental",
- "Male",
+ "Glucose",
"Insulin",
- "Reactive Oxygen Species",
- "Blood Glucose",
- "Streptozocin",
- "Phosphate-Binding Proteins",
- "Disease Progression",
- "Interleukin-18",
- "Interleukin-1beta",
- "Pancreas",
- "Signal Transduction",
- "Mice, Inbred C57BL",
- "Insulin Resistance",
- "Gasdermins"
- ]
+ "Animals",
+ "Lipid Metabolism"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "28"
+ }
},
{
- "PMID": "39675483",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Factors influencing the acceptability of automated insulin delivery systems in youths with type 1 diabetes and their parents.",
- "Abstract": "Participants receiving SAP therapy demonstrated higher expectations and optimistic views about AIDs. This treatment modality can act as a trampoline to AIDs despite individuals' glucose control and diabetes history.",
+ "PMID": "39185993",
+ "Title": "Irish medical journal",
+ "ArticleTitle": "Physical Activity Promotion for Young People with Type 1 Diabetes.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Male",
- "Female",
- "Insulin Infusion Systems",
+ "Exercise",
+ "Health Promotion",
"Adolescent",
- "Parents",
+ "Child"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "39182981",
+ "Title": "Endocrinologia, diabetes y nutricion",
+ "ArticleTitle": "Revolutionizing the management of diabetes: The promise of connected insulin pens and caps.",
+ "Abstract": "",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
"Insulin",
- "Blood Glucose Self-Monitoring",
- "Child",
"Hypoglycemic Agents",
- "Patient Acceptance of Health Care",
- "Surveys and Questionnaires",
- "Blood Glucose",
- "Adult"
- ]
+ "Diabetes Mellitus",
+ "Insulin Infusion Systems",
+ "Diabetes Mellitus, Type 1",
+ "Equipment Design"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "26"
+ }
},
{
- "PMID": "39675356",
- "Title": "Arquivos de neuro-psiquiatria",
- "ArticleTitle": "Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics.",
- "Abstract": "\u2003In the present study, we found no association involving the ",
+ "PMID": "39176556",
+ "Title": "Studies in health technology and informatics",
+ "ArticleTitle": "Prediction of Poor Glycemic Control in Children with Type 1 Diabetes.",
+ "Abstract": "This study developed and validated a machine learning model for predicting glycemic control in children with type 1 diabetes at the time of diagnosis, revealing age at diagnosis as the most informative predictor.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Diabetes Mellitus, Type 1",
"Humans",
- "Methylenetetrahydrofolate Reductase (NADPH2)",
- "Female",
+ "Child",
+ "Machine Learning",
+ "Glycemic Control",
"Male",
"Adolescent",
- "Child",
- "Interleukin-4",
- "Polymorphism, Genetic",
- "Diabetic Neuropathies",
- "Diabetes Mellitus, Type 1",
- "Genotype",
- "Genetic Predisposition to Disease",
- "Neural Conduction"
- ]
+ "Female",
+ "Blood Glucose",
+ "Child, Preschool",
+ "Glycated Hemoglobin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39673446",
- "Title": "Health technology assessment (Winchester, England)",
- "ArticleTitle": "Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.",
- "Abstract": "This award was funded by the National Institute for Health and Care Research (NIHR) Evidence Synthesis programme (NIHR award ref: NIHR133547) and is published in full in ",
+ "PMID": "39163549",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Management of Prolonged Aerobic Exercise in People With Type 1 Diabetes on Automated Insulin Delivery Systems: A Randomized Controlled Study.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Cost-Benefit Analysis",
+ "Exercise",
"Insulin Infusion Systems",
- "Blood Glucose Self-Monitoring",
"Insulin",
- "Blood Glucose",
- "Hypoglycemic Agents",
- "Models, Economic",
- "Glycated Hemoglobin",
- "Quality-Adjusted Life Years",
- "Randomized Controlled Trials as Topic",
- "Algorithms"
- ]
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "20"
+ }
},
{
- "PMID": "39673230",
- "Title": "Internal medicine journal",
- "ArticleTitle": "Comparison of cardiovascular risk prediction in type 1 diabetes: an Australian viewpoint.",
- "Abstract": "Cardiovascular disease (CVD) is a significant burden in individuals with type 1 diabetes mellitus (T1DM). Yet the optimal method of CVD risk stratification remains uncertain. We found that the new Australian CVD risk calculator could overestimate risk category compared with the Steno Type 1 Risk Engine and underestimate risk category compared with the new Swedish/Scottish prediction tool, both of which were validated for T1DM. More research is needed to derive a CVD risk assessment pathway for individuals with T1DM in Australia.",
+ "PMID": "39151730",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Case series of using automated insulin delivery to improve glycaemic control in people with type 1 diabetes and end stage kidney disease on haemodialysis.",
+ "Abstract": "Automated insulin delivery (AID) in people with type 1 diabetes (pwT1D) and end-stage kidney disease (ESKD) on haemodialysis (HD) has not been reported previously. We describe practical considerations and our findings in four pwT1D on HD for ESKD where AID was safely implemented, with significant improvements in time in range.",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "Cardiovascular Diseases",
- "Australia",
- "Risk Assessment",
+ "Kidney Failure, Chronic",
+ "Renal Dialysis",
+ "Insulin",
"Male",
+ "Insulin Infusion Systems",
"Female",
- "Adult",
"Middle Aged",
- "Heart Disease Risk Factors",
- "Risk Factors"
- ]
+ "Glycemic Control",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Blood Glucose",
+ "Aged",
+ "Diabetic Nephropathies"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "17"
+ }
},
{
- "PMID": "39670552",
- "Title": "The American journal of nursing",
- "ArticleTitle": "Original Research: Exploring the Use of Passive vs. Active Insulin Safety Pen Needle Devices in a Pediatric Population: A Feasibility Study.",
- "Abstract": "As frontline workers in patient care, nurses can lead the innovation and development of new treatment approaches, protocols, and equipment. This nurse-led study explored the nurses' perceptions about the feasibility of a new active SPN device versus the passive SPN device in terms of safety, ease of use, ease of and confidence in dose administration, and ease of teaching device use to pediatric patients and their caregivers. The RNs' clear preference for the active over the passive SPN device suggests that the newer, active devices warrant more widespread use in hospital settings, with further research also recommended.",
+ "PMID": "39141969",
+ "Title": "Rehabilitacion",
+ "ArticleTitle": "[Double diabetes mellitus. Double challenge for the exercise prescription. Systematic review].",
+ "Abstract": "Double diabetes (DD) refers to patients with type 1 diabetes who have developed insulin resistance. The objective of this review is to update relevant information on the prescription of physical activity, pharmacological adjustments and consumption of carbohydrates in DD. A systematic search for scientific articles was carried out in the following databases: PubMed, Cochrane, EBSCO, WoS, ScienceDirect and Medline. The evidence analyzed shows that both physical activity (PA) and physical exercise (PE) are essential to achieve metabolic control in people with DD. Physiological considerations such as: insulin adjustments, insulin injection sites, time to perform PA and PE, absolute and relative contraindications are essential to avoid complications, especially hypoglycemia.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Feasibility Studies",
- "Insulin",
- "Child",
- "Female",
- "Male",
- "Needlestick Injuries",
- "Injections, Subcutaneous",
- "Needles",
- "Adolescent",
"Diabetes Mellitus, Type 1",
- "Child, Preschool",
+ "Insulin Resistance",
+ "Exercise Therapy",
"Hypoglycemic Agents",
- "Young Adult"
- ]
+ "Exercise",
+ "Insulin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "14"
+ }
},
{
- "PMID": "39667114",
- "Title": "Vaccine",
- "ArticleTitle": "Seroconversion following PPSV23 vaccination in children with type 1 diabetes mellitus.",
- "Abstract": "Response to pneumococcal vaccination has not previously been assessed in children with T1DM, and our study demonstrates robust humoral immune response to PPSV23 vaccination in these children. Larger studies with a diverse representation and longer follow up to assess how humoral seroconversion correlates with clinical response to PPSV23 in this vulnerable population are warranted.",
+ "PMID": "39140954",
+ "Title": "Journal of the American College of Cardiology",
+ "ArticleTitle": "Cardiorenal Outcomes in Middle-Aged and Older Adults With Type 1 and Type 2 Diabetes.",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Middle Aged",
"Male",
"Female",
- "Child",
- "Prospective Studies",
- "Pneumococcal Vaccines",
- "Seroconversion",
- "Pilot Projects",
- "Antibodies, Bacterial",
- "Child, Preschool",
- "Immunoglobulin G",
- "Adolescent",
- "Vaccination",
- "Pneumococcal Infections",
- "Glycated Hemoglobin",
- "Streptococcus pneumoniae"
- ]
+ "Aged",
+ "Diabetes Mellitus, Type 1",
+ "Cardio-Renal Syndrome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "14"
+ }
},
{
- "PMID": "39666416",
- "Title": "Medicina",
- "ArticleTitle": "[Advances in continuous glucose monitoring: evidence of a new generation technology].",
- "Abstract": "Continuous glucose monitoring (CGM) provides comprehensive and dynamic information to guide the management of diabetes mellitus (DM). This paper summarizes the evidence and implications of the use of the new CGM system, FreeStyle Libre 2 (FSL2). A global review of the literature on the use of FSL2 in people with DM was performed. All types of studies were included. The evidence is presented qualitatively together with expert clinical opinion. FSL2 is an integrated CGM system with real-time glucose readings (no scanning required) and customizable alarms. In studies of subjects aged 2 years and older with DM1 or DM2, the overall mean absolute relative difference for FSL2 was 8.2%, with a high degree of clinical accuracy. Compared to blood monitoring in DM1, studies show higher time within range, lower time below range and lower time above range at 4, 8 and 12 weeks of FSL2 use. These results were confirmed in observational studies in DM, where the majority of FSL2 users reported greater satisfaction with treatment and a significant improvement in quality of life. In concluded, Including the FSL2 system in the management of people with DM would also reduce the risks associated with DM complications, improving the prognosis of this population and allowing for the appropriate use of healthcare resources.",
+ "PMID": "39134460",
+ "Title": "Diabetes, obesity & metabolism",
+ "ArticleTitle": "Continuous glucose monitoring and all-cause mortality in insulin-using population with diabetes and cognitive impairment.",
+ "Abstract": "",
"Predictions": [
- "Diabetes",
"Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Female",
+ "Cognitive Dysfunction",
+ "Insulin",
+ "Male",
+ "Hypoglycemic Agents",
+ "Aged",
+ "Diabetes Mellitus, Type 2",
"Blood Glucose Self-Monitoring",
"Blood Glucose",
- "Diabetes Mellitus",
- "Quality of Life",
- "Diabetes Mellitus, Type 2",
+ "Middle Aged",
"Diabetes Mellitus, Type 1",
"Continuous Glucose Monitoring"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "13"
+ }
},
{
- "PMID": "39665438",
- "Title": "ACS applied materials & interfaces",
- "ArticleTitle": "Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted \u03b2 Cells.",
- "Abstract": "Treating type 1 diabetes (T1D) through \u03b2-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved \u03b2-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of \u03b2-cell encapsulation.",
+ "PMID": "39120509",
+ "Title": "The Journal of nursing education",
+ "ArticleTitle": "A Week With Type 1 Diabetes: A Concept-Based Active Learning Activity.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Animals",
- "Mice",
- "Insulin-Secreting Cells",
- "Diabetes Mellitus, Experimental",
- "Cell Survival",
- "Anti-Inflammatory Agents",
- "Polytetrafluoroethylene",
+ "Humans",
"Diabetes Mellitus, Type 1",
- "Male",
- "Macrophages",
- "Membranes, Artificial",
- "Mice, Inbred C57BL",
- "Cell Encapsulation",
- "Islets of Langerhans Transplantation"
- ]
+ "Problem-Based Learning",
+ "Patient Education as Topic",
+ "Nursing Education Research"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "9"
+ }
},
{
- "PMID": "39664107",
- "Title": "Journal of diabetes research",
- "ArticleTitle": "Diabetic Neuropathy Is Related to Rhinencephalon Degeneration in Adults With Type 1 Diabetes.",
- "Abstract": {
- "b": "Conclusions:",
- "i": "p",
- "sup": "3"
- },
+ "PMID": "39109471",
+ "Title": "Diabetes, obesity & metabolism",
+ "ArticleTitle": "Adapting study designs of Mendelian randomization for disease complications: Insights from type 1 diabetes complications research.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Male",
+ "Mendelian Randomization Analysis",
"Diabetes Mellitus, Type 1",
- "Adult",
- "Middle Aged",
- "Diabetic Neuropathies",
- "Female",
- "Magnetic Resonance Imaging",
- "Olfactory Bulb",
- "Aged",
- "Young Adult",
- "Adolescent",
- "Case-Control Studies",
- "Smell"
- ]
+ "Research Design",
+ "Diabetes Complications"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "7"
+ }
},
{
- "PMID": "39663236",
- "Title": "European journal of pediatrics",
- "ArticleTitle": "Translation, adaptation, and psychometric evaluation of the Quality of Life in a Child's Chronic Disease Questionnaire for the Swedish context.",
- "Abstract": "\u2022\u00a0The Swedish version of the Quality of Life in a Child's Chronic Disease Questionnaire has two subscales\u00a0compared to the original's five. \u2022\u00a0The instrument may potentially be useful for clinical screening of families who have the greatest need for\u00a0supportive interventions.",
+ "PMID": "39104127",
+ "Title": "Journal of diabetes science and technology",
+ "ArticleTitle": "Ramadan Fasting, One Less Barrier Raised by Automated Insulin Delivery.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Quality of Life",
- "Psychometrics",
- "Sweden",
- "Child",
- "Male",
- "Female",
- "Surveys and Questionnaires",
- "Chronic Disease",
- "Adolescent",
- "Reproducibility of Results",
+ "Fasting",
+ "Insulin",
+ "Insulin Infusion Systems",
+ "Islam",
+ "Hypoglycemic Agents",
"Diabetes Mellitus, Type 1",
- "Translations",
- "Asthma",
- "Parents",
- "Factor Analysis, Statistical",
- "Child, Preschool"
- ]
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "6"
+ }
+ },
+ {
+ "PMID": "39084842",
+ "Title": "The Medical clinics of North America",
+ "ArticleTitle": "Newer Outpatient Diabetes Therapies and Technologies.",
+ "Abstract": "New diabetes drugs such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and glucose-dependent insulinotropic peptide/GLP-1 RAs have emerged to show hemoglobin A1c (HbA1c) reduction, weight loss, and cardiovascular benefits. Similarly, sodium-glucose cotransporter 2 inhibitors' benefits span from HbA1c decrease to cardiovascular and renoprotective effects. Diabetes technology has expanded to include type 2 diabetes mellitus, with literature supporting its use in T2DM on any insulin regimen. Connected insulin pens and insulin delivery devices have opened new solutions to insulin users and automated insulin delivery systems have become the standard of care therapy for type 1 diabetes mellitus.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Insulin",
+ "Glycated Hemoglobin",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Insulin Infusion Systems",
+ "Ambulatory Care",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "1"
+ }
},
{
- "PMID": "39661959",
- "Title": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
- "ArticleTitle": "Stability and change of illness identity in Belgian youth with type 1 diabetes: a latent transition analysis.",
- "Abstract": "The present study informed both theory and clinical practice on how illness identity is experienced by youth with T1D from a person-centered perspective. In addition, the results provided insight into which aspects are meaningfully related to illness identity integration, supporting tailored interventions for youth with T1D.",
+ "PMID": "39084810",
+ "Title": "Endocrinology and metabolism clinics of North America",
+ "ArticleTitle": "Updates in the Management of Type 1 Diabetes in Pregnancy.",
+ "Abstract": "The care of pregnant individuals with type 1 diabetes mellitus has experienced significant advancements in recent years. Preconception counseling has re-emerged as a core dimension of management. Continuous glucose monitoring plays an increasingly useful and beneficial role in gestational glycemic monitoring, a practice informed by improved maternofetal outcomes. While studies have not shown that continuous subcutaneous insulin infusion is superior to multiple daily injections of insulin for glycemic control, recent work has signaled that hybrid closed-loop systems with pregnancy-specific targets could meaningfully improve glycemic control and potentially ameliorate maternofetal outcomes while reducing self-care burden.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Pregnancy",
"Diabetes Mellitus, Type 1",
"Female",
- "Adolescent",
- "Male",
- "Belgium",
- "Longitudinal Studies",
- "Young Adult",
- "Adult",
- "Self Concept"
- ]
+ "Pregnancy in Diabetics",
+ "Insulin Infusion Systems",
+ "Blood Glucose Self-Monitoring",
+ "Insulin",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "1"
+ }
},
{
- "PMID": "39658973",
- "Title": "JPMA. The Journal of the Pakistan Medical Association",
- "ArticleTitle": "Comparison of ketoacidosis in type 1 and 2 diabetic patients with and without concurrent COVID-19 and determining the factors affecting their treatment and survival: a retrospective cohort study.",
- "Abstract": "Patients of diabetic ketoacidosis with coronavirus disease-2019 had poor survival outcomes compared to diabetic ketoacidosis patients without coronavirus disease-2019.",
+ "PMID": "39083683",
+ "Title": "Diabetes care",
+ "ArticleTitle": "History of the Diabetes Control and Complications Trial and Its Follow-up Epidemiology of Diabetes Interventions and Complications Study: Studies That Changed the Treatment of Type 1 Diabetes.",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Diabetic Ketoacidosis",
- "COVID-19",
- "Male",
- "Female",
- "Middle Aged",
- "Retrospective Studies",
- "Pakistan",
+ "Diabetes Complications",
"Diabetes Mellitus, Type 1",
- "Diabetes Mellitus, Type 2",
- "Adult",
- "SARS-CoV-2",
- "Survival Rate",
- "Incidence"
- ]
+ "Follow-Up Studies",
+ "History, 20th Century"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "31"
+ }
},
{
- "PMID": "39658119",
- "Title": "Saudi medical journal",
- "ArticleTitle": "Comparison of pediatric diabetic ketoacidosis in newly diagnosed versus known patients with type 1 diabetes mellitus: A single-center study.",
- "Abstract": "The DKA incidence was higher in newly diagnosed patients, particularly in the middle-childhood age group. Economic factors may contribute to disease manifestations, and newly diagnosed patients had longer DKA symptom durations. The higher DKA incidence and severity in newly diagnosed patients, particularly in certain age groups, underscores the importance of increased disease awareness and early diagnosis.",
+ "PMID": "39078899",
+ "Title": "British journal of hospital medicine (London, England : 2005)",
+ "ArticleTitle": "Not all ketosis is type 1 - remember Flatbush.",
+ "Abstract": "A 35-year-old otherwise healthy gentleman from Togo, was referred as a 'walk-in' to our clinic with polyuria and polydipsia, and a glycated haemoglobin (Hba1c) of 119 mmol/mol (13.1%). The patient also noted 5kg weight loss over a short span of time. He had a significant family history of Type 2 Diabetes Mellitus (T2DM). Initial blood tests revealed a blood glucose of 22.84 mmol/L, with positive ketones (1.2 mmol/L). Urinalysis showed glycosuria (1000 mg/dL) but was negative for nitrites and white cells. Renal, liver and thyroid function tests were all within normal limits. He had mild metabolic acidosis.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Male",
+ "Adult",
+ "Diabetes Mellitus, Type 2",
"Diabetic Ketoacidosis",
"Diabetes Mellitus, Type 1",
- "Child",
- "Male",
- "Female",
- "Retrospective Studies",
- "Adolescent",
- "Saudi Arabia",
- "Child, Preschool",
- "Incidence",
- "Polyuria",
- "Abdominal Pain",
- "Polydipsia",
- "Vomiting",
- "Age Factors",
- "Severity of Illness Index"
- ]
+ "Diagnosis, Differential",
+ "Glycated Hemoglobin",
+ "Ketosis",
+ "Blood Glucose",
+ "Polyuria"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "30"
+ }
},
{
- "PMID": "39658013",
- "Title": "JMIR formative research",
- "ArticleTitle": "Improving Self-Efficacy, Quality of Life, and Glycemic Control in Adolescents With Type 1 Diabetes: Randomized Controlled Trial for the Evaluation of the Family-Centered Empowerment Model.",
- "Abstract": "ClinicalTrials.gov NCT06694467; https://clinicaltrials.gov/study/NCT06694467.",
+ "PMID": "39072586",
+ "Title": "Medical anthropology",
+ "ArticleTitle": "Controlling the Diabetic Body? Managing Chronic Illness with Wearable Technology.",
+ "Abstract": "I explore the experience of managing type 1 diabetes with wearable technology. Type 1 diabetes is a chronic illness which requires continuous maintenance to keep the blood glucose levels within range. Using autoethnography, I investigate both the practices of translating information from technology and from senses, and also from health authorities, into practices. I conclude that the management of type 1 diabetes is informed by an urge to control the body, but this situation can be understood otherwise from a logic of care.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Wearable Electronic Devices",
+ "Anthropology, Medical",
"Diabetes Mellitus, Type 1",
- "Adolescent",
+ "Chronic Disease",
"Female",
"Male",
- "Self Efficacy",
- "Quality of Life",
- "Jordan",
- "Glycemic Control",
- "Empowerment",
- "Glycated Hemoglobin",
- "Child"
- ]
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "29"
+ }
},
{
- "PMID": "39653802",
- "Title": "Diabetologia",
- "ArticleTitle": "The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD).",
- "Abstract": "Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provide additional health benefits but can cause glucose fluctuations, which challenges current AID systems. While an increasing number of clinical trials and reviews are being published on different AID systems and PA, it seems prudent at this time to collate this information and develop a position statement on the topic. This joint European Association for the Study of Diabetes (EASD)/International Society for Pediatric and Adolescent Diabetes (ISPAD) position statement reviews current evidence on AID systems and provides detailed clinical practice points for managing PA in children, adolescents and adults with type 1 diabetes using AID technology. It discusses each commercially\u00a0available AID system individually and provides guidance on their use in PA. Additionally, it addresses different glucose responses to PA and provides stratified therapy options to maintain glucose levels within the target ranges for these age groups.",
+ "PMID": "39053692",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Managing blood glucose levels with a hybrid closed-loop system in a patient with type 1 diabetes mellitus on enteral nutrition: A case report.",
+ "Abstract": "The achievement of glycemic management is challenging in patients with diabetes on enteral nutrition, limited literature exists on hybrid closed-loop systems' efficacy in such a situation. We described the case of a patient with type 1 diabetes treated by advanced hybrid closed loop on enteral nutrition with satisfactory glycemic management.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Blood Glucose",
"Diabetes Mellitus, Type 1",
- "Exercise",
- "Insulin Infusion Systems",
- "Insulin",
- "Adolescent",
- "Child",
+ "Enteral Nutrition",
+ "Glycemic Control",
"Hypoglycemic Agents",
- "Europe",
- "Blood Glucose",
- "Adult"
- ]
+ "Insulin",
+ "Insulin Infusion Systems"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "26"
+ }
},
{
- "PMID": "39652325",
- "Title": "JAMA pediatrics",
- "ArticleTitle": "New-Onset Type 1 and Type 2 Diabetes Among Korean Youths During the COVID-19 Pandemic.",
- "Abstract": "These findings suggest that the incidence and severity of T1D and T2D among South Korean youths increased during the COVID-19 pandemic. The cohort analysis does not support SARS-CoV-2 infection itself as being directly associated with incident diabetes.",
+ "PMID": "38986438",
+ "Title": "Immunity",
+ "ArticleTitle": "Scavengers in islets fuel diabetic autoimmunity.",
+ "Abstract": "Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target \u03b2 cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et\u00a0al. examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8 T\u00a0cells.",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
- "Humans",
- "COVID-19",
- "Diabetes Mellitus, Type 2",
+ "Autoimmunity",
"Diabetes Mellitus, Type 1",
- "Male",
- "Republic of Korea",
- "Adolescent",
- "Female",
- "Child",
- "Incidence",
- "Child, Preschool",
- "Young Adult",
- "Cohort Studies",
- "Pandemics",
- "SARS-CoV-2"
- ]
+ "Islets of Langerhans",
+ "Humans",
+ "Animals",
+ "Macrophages",
+ "CD8-Positive T-Lymphocytes",
+ "Insulin-Secreting Cells",
+ "Lipoproteins, LDL"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "11"
+ }
},
{
- "PMID": "39652177",
- "Title": "Dermatologie (Heidelberg, Germany)",
- "ArticleTitle": "[Atopic dermatitis and diabetes mellitus-is there a\u00a0link?].",
- "Abstract": "Clinicians should be aware of this potential correlation in both adult and pediatric patients and consider the importance of an interdisciplinary approach for the management of atopic dermatitis. Further research is needed to determine possible associations between atopic dermatitis and diabetes mellitus in specific populations.",
+ "PMID": "38972092",
+ "Title": "Artificial intelligence in medicine",
+ "ArticleTitle": "End-to-end offline reinforcement learning for glycemia control.",
+ "Abstract": "The development of closed-loop systems for glycemia control in type I diabetes relies heavily on simulated patients. Improving the performances and adaptability of these close-loops raises the risk of over-fitting the simulator. This may have dire consequences, especially in unusual cases which were not faithfully - if at all - captured by the simulator. To address this, we propose to use model-free offline RL agents, trained on real patient data, to perform the glycemia control. To further improve the performances, we propose an end-to-end personalization pipeline, which leverages offline-policy evaluation methods to remove altogether the need of a simulator, while still enabling an estimation of clinically relevant metrics for diabetes.",
"Predictions": [
- "Diabetes",
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Dermatitis, Atopic",
- "Comorbidity",
- "Risk Factors",
- "Diabetes Mellitus, Type 2",
+ "Glycemic Control",
+ "Blood Glucose",
"Diabetes Mellitus, Type 1",
- "Diabetes Mellitus",
- "Child",
- "Adult"
- ]
+ "Hypoglycemic Agents",
+ "Machine Learning",
+ "Insulin Infusion Systems",
+ "Insulin",
+ "Computer Simulation",
+ "Reinforcement, Psychology",
+ "Blood Glucose Self-Monitoring"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "8"
+ }
},
{
- "PMID": "39649224",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis.",
- "Abstract": "Our findings collectively underscore the detrimental impact of AS on the development of diabetes, highlighting the critical influence of autoimmune disorders in diabetes onset. This provides profound insights into the pathogenesis of diabetes from an immunological standpoint.",
+ "PMID": "38955658",
+ "Title": "Primary care diabetes",
+ "ArticleTitle": "Clinical practice recommendations for management of Diabetes Mellitus in Arab region: An expert consensus statement from Arab Diabetes Forum (ADF).",
+ "Abstract": "Prevalence of diabetes in Arab region has significantly increased, resulting in a significant economic burden on healthcare systems. This surge can be attributed to obesity, rapid urbanization, changing dietary habits, and sedentary lifestyles. The Arab Diabetes Forum (ADF) has established localized recommendations to tackle the region's rising diabetes prevalence. The recommendations, which incorporate worldwide best practices, seek to enhance the quality of treatment for people with diabetes by raising knowledge and adherence among healthcare providers. The guidelines include comprehensive recommendations for screening, diagnosing, and treating type 1 and type 2 diabetes in children and adults for better overall health results.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
+ "Adult",
+ "Child",
"Humans",
- "Blood Glucose",
+ "Consensus",
"Diabetes Mellitus, Type 1",
"Diabetes Mellitus, Type 2",
- "Genetic Predisposition to Disease",
- "Genome-Wide Association Study",
- "Glycated Hemoglobin",
- "Mendelian Randomization Analysis",
- "Polymorphism, Single Nucleotide",
- "Spondylitis, Ankylosing"
- ]
+ "Hypoglycemic Agents",
+ "Middle East",
+ "Predictive Value of Tests",
+ "Prevalence",
+ "Risk Factors",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "3"
+ }
},
{
- "PMID": "39648458",
- "Title": "Proteomics",
- "ArticleTitle": "Reduction of Chemokine CXCL9 Expression by Omega-3 Fatty Acids via ADP-Ribosylhydrolase ARH3 in MIN6 Insulin-Producing Cells.",
- "Abstract": "Type 1 diabetes (T1D) results from the autoimmune destruction of the insulin-producing \u03b2 cells of the pancreas. Omega-3 fatty acids protect \u03b2 cells and reduce the incidence of T1D, but the mechanism is poorly understood. We have shown that omega-3 fatty acids reduce pro-inflammatory cytokine-mediated \u03b2-cell apoptosis by upregulating the expression of the ADP-ribosylhydrolase ARH3. Here, we further investigate the \u03b2-cell protection mechanism of ARH3 by performing siRNA analysis of its gene Adprhl2 in MIN6 insulin-producing cells, subsequent treatment with a cocktail of the pro-inflammatory cytokines IL-1\u03b2\u00a0+\u00a0IFN-\u03b3\u00a0+\u00a0TNF-\u03b1, followed by proteomics analysis. ARH3 regulated proteins from several pathways related to the nucleus (splicing, RNA surveillance, and nucleocytoplasmic transport), mitochondria (metabolic pathways), and endoplasmic reticulum (protein folding). ARH3 also regulated the levels of proteins related to antigen processing and presentation, and the chemokine-signaling pathway. We further studied the role of ARH3 in regulating the chemokine CXCL9. We found that ARH3 reduces the cytokine-induced expression of CXCL9, which is dependent on omega-3 fatty acids. In conclusion, we demonstrate that omega-3 fatty acids regulate CXCL9 expression via ARH3, which may have a role in protecting \u03b2 cells from immune attack thereby preventing T1D development. Significance of the Study: Omega-3 fatty acids have a variety of health benefits. In type 1 diabetes, omega-3 fatty acids reduce the islet autoimmune response and the disease development. Here, we studied the pathways regulated by the adenosine diphosphate (ADP)-ribosylhydrolase ARH3, a protein whose expression is regulated by omega-3 fatty acids. We showed that ARH3 reduces the expression of chemokines in response to omega-3 fatty acids. This represents an anti-inflammatory mechanism of omega-3 fatty acids that might be involved with protection against type 1 diabetes development.",
+ "PMID": "38949871",
+ "Title": "Pediatric annals",
+ "ArticleTitle": "Loss to Follow-Up: Patients with Type 1 Diabetes During the SARS-CoV-2 Pandemic.",
+ "Abstract": "The SARS-CoV-2 (severe acute respiratory syndrome related coronavirus 2) pandemic revealed many flaws in our health care system. This review aims to explore the significance of loss to follow-up on patients with type 1 diabetes during the pandemic, the morbidity and mortality associated, and strategies to prevent loss to follow-up or to re-engage patients in longitudinal care. .",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Fatty Acids, Omega-3",
- "Chemokine CXCL9",
- "Insulin-Secreting Cells",
- "Animals",
- "Mice",
+ "Humans",
"Diabetes Mellitus, Type 1",
- "Cell Line",
- "Signal Transduction"
- ]
+ "COVID-19",
+ "Child",
+ "Lost to Follow-Up",
+ "SARS-CoV-2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "1"
+ }
},
{
- "PMID": "39645243",
- "Title": "Expert opinion on investigational drugs",
- "ArticleTitle": "Drugs stimulating insulin secretion in early clinical development for the treatment of type 1 diabetes: what's new?",
- "Abstract": "Drugs which enhance insulin secretion in individuals may offer clinical benefits to individuals with type 1 diabetes. However, the lack of beta-cell capacity introduces a challenge without regeneration of insulin-producing cells. Stem cell therapies combined with regulation of islet autoimmunity may offer the best prospect of increased insulin secretion in individuals with T1D.",
+ "PMID": "38923174",
+ "Title": "Journal of diabetes",
+ "ArticleTitle": "Are sodium-glucose cotransporter-2 inhibitors safe adjunctive drugs during insulin therapy in young children with type 1 diabetes? The first case of type 1 diabetes with SLC5A2 mutation.",
+ "Abstract": "Highlights A persistent glycosuria alongside hypoglycemia in pediatric type 1 diabetes mellitus needs further evaluation. Morning hypoglycemia is a limiting side effect of sodium glucose transporter 2 (SGLT2) inhibitors in children younger than 5\u2009years old. SLC5A2 mutation functioning as a SGLT2 inhibitor can result in acceptable range of glycated hemoglobin in younger children and lower required doses of insulin.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Sodium-Glucose Transporter 2 Inhibitors",
"Diabetes Mellitus, Type 1",
- "Hypoglycemic Agents",
- "Insulin-Secreting Cells",
- "Animals",
- "Drug Development",
- "Insulin Secretion",
+ "Sodium-Glucose Transporter 2",
"Insulin",
- "Disease Progression",
- "Glycemic Control"
- ]
+ "Mutation",
+ "Child, Preschool",
+ "Hypoglycemic Agents",
+ "Male",
+ "Blood Glucose",
+ "Female",
+ "Hypoglycemia",
+ "Glycated Hemoglobin",
+ "Drug Therapy, Combination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "26"
+ }
},
{
- "PMID": "39644976",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20\u00a0years of \"Diabete Sommerso\u00ae\" experience.",
- "Abstract": "Data from 1179 dives indicate that, with adherence to the safety protocol, scuba diving is safe and poses no risk of severe hypoglycemia for people with type 1 diabetes.",
+ "PMID": "38909002",
+ "Title": "Journal of science and medicine in sport",
+ "ArticleTitle": "Yoga as an alternative to cycling in type 1 diabetes: A preliminary study of acute effects on glucose levels.",
+ "Abstract": "We evaluated the acute effects of yoga compared to cycling on glucose change and variability, and the occurrence of hypoglycemia in adults with type 1 diabetes. Fifteen participants performed 50\u202fmin of cycling or yoga. Glucose values were collected before and after exercise. Coefficient of variation (CV) and hypoglycemic episodes were evaluated from the start up to 12\u202fh after exercise. Cycling and yoga significantly reduced glucose values during exercise, and CV was lower after yoga. One hypoglycemic episode occurred with yoga and seven with cycling. Yoga is a safe exercise that acutely reduces glucose values, but with lower risk of hypoglycemia compared to cycling.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Yoga",
"Diabetes Mellitus, Type 1",
- "Diving",
- "Adult",
- "Hypoglycemia",
+ "Blood Glucose",
"Male",
+ "Adult",
+ "Bicycling",
"Female",
- "Blood Glucose",
+ "Hypoglycemia",
"Young Adult",
- "Blood Glucose Self-Monitoring",
- "Glycated Hemoglobin",
- "Adolescent",
- "Middle Aged"
- ]
+ "Exercise"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "23"
+ }
},
{
- "PMID": "39642862",
- "Title": "Cell stem cell",
- "ArticleTitle": "Stem cell islet replacement in type 1 diabetes: From \"shelf\" to \"self\".",
- "Abstract": "Recently in Cell, Wang and colleagues",
+ "PMID": "38906333",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Participation and psychosocial supports in the school setting for children with type 1 diabetes: A discrete choice experiment of carer priority.",
+ "Abstract": "School-based diabetes care is an important consideration for clinicians and families alike. This Discrete-Choice Experiment describes parental preference for enhanced psychosocial and activity-focused supports over academic supports for children with Type 1 diabetes in Australian primary and secondary schools.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Diabetes Mellitus, Type 1",
"Humans",
- "Islets of Langerhans Transplantation",
- "Induced Pluripotent Stem Cells",
- "Islets of Langerhans",
- "Animals"
- ]
- },
- {
- "PMID": "39639901",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Health economic evaluation of structured education programs for patients with diabetes: a systematic review.",
- "Abstract": "This study confirms the cost-effectiveness of structured education programs for diabetes and highlights their importance for patients with type 2 diabetes who have HbA1c levels exceeding 7% and are receiving non-insulin therapy. Additionally, the potential advantages of incorporating telecommunication technologies into structured diabetes education were emphasized. These findings offer valuable insights and guidance for decision-making in diabetes management and clinical practice, contributing to the optimization of medical resource allocation and the improvement of health status and quality of life for patients.",
- "Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes Mellitus, Type 1",
+ "Child",
+ "Male",
+ "Female",
+ "Adolescent",
+ "Schools",
+ "Parents",
+ "Australia",
+ "Caregivers",
+ "School Health Services",
+ "Social Support",
+ "Choice Behavior"
],
- "MeshTerms": [
- "Humans",
- "Cost-Benefit Analysis",
- "Diabetes Mellitus, Type 2",
- "Patient Education as Topic",
- "Diabetes Mellitus, Type 1"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "22"
+ }
},
{
- "PMID": "39636437",
- "Title": "Diabetologia",
- "ArticleTitle": "Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.",
- "Abstract": "CD226 blockade reduces T cell cytotoxicity and improves Treg function, representing a targeted and rational approach for restoring immune regulation in type 1 diabetes.",
+ "PMID": "38886067",
+ "Title": "Cold Spring Harbor perspectives in medicine",
+ "ArticleTitle": "Advancing Animal Models of Human Type 1 Diabetes.",
+ "Abstract": "Multiple rodent models have been developed to study the basis of type 1 diabetes (T1D). However, nonobese diabetic (NOD) mice and derivative strains still provide the gold standard for dissecting the basis of the autoimmune responses underlying T1D. Here, we review the developmental origins of NOD mice, and how they and derivative strains have been used over the past several decades to dissect the genetic and immunopathogenic basis of T1D. Also discussed are ways in which the immunopathogenic basis of T1D in NOD mice and humans are similar or differ. Additionally reviewed are efforts to \"humanize\" NOD mice and derivative strains to provide improved models to study autoimmune responses contributing to T1D in human patients.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
+ "Diabetes Mellitus, Type 1",
"Animals",
- "T-Lymphocytes, Regulatory",
- "Mice, Inbred NOD",
+ "Humans",
"Mice",
- "Female",
- "Diabetes Mellitus, Type 1",
- "Antigens, Differentiation, T-Lymphocyte",
- "Antibodies, Monoclonal"
- ]
+ "Disease Models, Animal",
+ "Mice, Inbred NOD",
+ "Autoimmunity"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "18"
+ }
},
{
- "PMID": "39632776",
- "Title": "Diabetes, obesity & metabolism",
- "ArticleTitle": "The clinical importance of measuring glycaemic variability: Utilising new metrics to optimise glycaemic control.",
- "Abstract": "With the widespread use of continuous glucose monitoring (CGM), glycaemic variability (GV) is a glucose metric that has been gaining increasing attention. However, unlike other glucose metrics that are easily defined and have clear targets, GV has a large number of different measures given the complexity involved in assessment. While variabilities in HbA1c, fasting and postprandial glucose have been incorporated under the GV banner, short-term variability in glucose, within day and between days, is more in keeping with the correct definition of GV. This review is focused on short-term GV, as assessed by CGM data, although studies calculating GV from capillary glucose testing are also mentioned as appropriate. The different measures of GV are addressed, and their potential role in microvascular and macrovascular complications, as well as patient-related outcomes, discussed. It should be noted that the independent role of GV in vascular pathology is not always clear, given the inconsistent findings in different populations and the close association between GV and hypoglycaemia, itself an established risk factor for adverse outcomes. Therefore, this review attempts, where possible, to disentangle the contribution of GV to diabetes complications from other glycaemic parameters, particularly hypoglycaemia. Evidence to date strongly suggests an independent role for GV in vascular pathology but future large-scale outcome studies are required to fully understand the exact contribution of this metric to vascular complications. This can be followed by setting appropriate GV measures and targets in different diabetes subgroups, in order to optimise glycaemic management and limit the risk of complications.",
+ "PMID": "38812340",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Diabetic gastroparesis and type 1 diabetes].",
+ "Abstract": "Gastroparesis is a rare and late microvascular complication, but a significant one of diabetes. Defined by a slowing of gastric emptying, this condition manifests with nonspecific gastrointestinal symptoms, including nausea, vomiting, abdominal pain, postprandial fullness, and early satiety. Faced with such a clinical presentation, it is often challenging to diagnose gastroparesis. In this article, we discuss the diagnostic procedures, as well as therapeutic approaches and management of the disease.",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Blood Glucose",
- "Glycemic Control",
- "Blood Glucose Self-Monitoring",
- "Hypoglycemia",
- "Glycated Hemoglobin",
- "Diabetes Mellitus, Type 2",
- "Diabetic Angiopathies",
+ "Gastroparesis",
"Diabetes Mellitus, Type 1",
- "Hypoglycemic Agents",
- "Postprandial Period",
- "Clinical Relevance"
- ]
+ "Gastric Emptying"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "30"
+ }
},
{
- "PMID": "39632164",
- "Title": "Archives de pediatrie : organe officiel de la Societe francaise de pediatrie",
- "ArticleTitle": "Caregiver satisfaction with the use of continuous glucose monitoring and flash glucose monitoring in very young children with type 1 diabetes.",
- "Abstract": "The vast majority of parents in this group of young children with T1D were satisfied with continuous or flash glucose monitoring. Satisfaction was strongly associated with confidence in the reliability of the device. Reported adverse effects such as skin reaction and difficulties attaching the device highlight the importance of data on real-life use.",
+ "PMID": "38780343",
+ "Title": "The American journal of nursing",
+ "ArticleTitle": "Continuous Glucose Monitoring Is Associated with Lower Risk of Diabetic Retinopathy.",
+ "Abstract": "According to this study: In adults with type 1 diabetes, continuous glucose monitoring (CGM) was associated with lower odds of developing diabetic retinopathy and proliferative diabetic retinopathy.No associations were found between CGM use, insulin pump use, or the use of both CGM and an insulin pump with progression of diabetic retinopathy.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
+ "Diabetic Retinopathy",
"Diabetes Mellitus, Type 1",
- "Blood Glucose Self-Monitoring",
- "Female",
"Male",
- "Child, Preschool",
- "Surveys and Questionnaires",
- "Infant",
- "Parents",
- "Insulin Infusion Systems",
- "Patient Satisfaction",
+ "Female",
+ "Blood Glucose Self-Monitoring",
+ "Adult",
+ "Middle Aged",
"Blood Glucose",
- "Child",
- "Caregivers",
+ "Insulin Infusion Systems",
+ "Risk Factors",
"Continuous Glucose Monitoring"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "23"
+ }
},
{
- "PMID": "39629047",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Efficacy and safety of once-weekly insulin versus once-daily insulin in patients with type 1 and type 2 diabetes mellitus: an updated meta-analysis of randomized controlled trials.",
- "Abstract": "https://www.crd.york.ac.uk/PROSPERO, Identifier CRD42024496812.",
+ "PMID": "38757999",
+ "Title": "Nursing",
+ "ArticleTitle": "Sibling adjustment to diabetes and educational needs: A literature review.",
+ "Abstract": "As cases of type 1 diabetes mellitus (T1DM) increase, so do their impact on sibling relationships. This literature review of four databases from 2010 to 2024 discusses findings from five studies and the themes that emerged: education needs and family functioning. Improvements in family-centered care and education are needed for siblings of children with T1DM.",
"Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
+ "Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Blood Glucose",
"Diabetes Mellitus, Type 1",
- "Diabetes Mellitus, Type 2",
- "Drug Administration Schedule",
- "Glycated Hemoglobin",
- "Hypoglycemia",
- "Hypoglycemic Agents",
- "Insulin",
- "Insulin, Long-Acting",
- "Randomized Controlled Trials as Topic",
- "Treatment Outcome"
- ]
+ "Siblings",
+ "Adaptation, Psychological",
+ "Child",
+ "Sibling Relations",
+ "Patient Education as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "17"
+ }
},
{
- "PMID": "39627081",
- "Title": "Archives de pediatrie : organe officiel de la Societe francaise de pediatrie",
- "ArticleTitle": "Impact of early administration of long-acting insulin on ketosis rebound in diabetic ketoacidosis.",
- "Abstract": "Our study is the first pediatric study suggesting that earlier injection of long-acting insulin after resolution of DKA in children reduces the risk of ketosis rebound.",
+ "PMID": "38703638",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes.",
+ "Abstract": "In a cohort of 1817 children with type 1 diabetes (T1D), short-term hyperglycemia was associated with transient albuminuria (11\u00a0% during new-onset T1D without diabetic ketoacidosis (DKA), 12\u00a0% during/after DKA, 6\u00a0% during routine screening). Our findings have implications regarding future risk of diabetic kidney disease and further investigation is needed.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Diabetic Ketoacidosis",
- "Retrospective Studies",
- "Child",
- "Female",
+ "Diabetes Mellitus, Type 1",
+ "Albuminuria",
+ "Hyperglycemia",
"Male",
+ "Female",
+ "Child",
+ "Diabetic Nephropathies",
"Adolescent",
- "Child, Preschool",
- "Infant",
- "Hypoglycemic Agents",
- "Diabetes Mellitus, Type 1",
- "Insulin, Long-Acting",
- "Insulin",
- "Infant, Newborn",
- "Infusions, Intravenous"
- ]
+ "Diabetic Ketoacidosis",
+ "Cohort Studies",
+ "Severity of Illness Index",
+ "Child, Preschool"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "5"
+ }
},
{
- "PMID": "39626097",
- "Title": "Diabetes care",
- "ArticleTitle": "Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes.",
- "Abstract": "In total, we identified heterogeneity in T1D genetic risk dependent on high-risk HLA-DR3/DR4 haplotype, which uncovers disease mechanisms and enables more accurate prediction of T1D across the HLA background.",
+ "PMID": "38696976",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes.",
+ "Abstract": "Managing complications in Type 1 diabetes (T1D) remains challenging. HLA genes, particularly DR and DQ, are linked to T1D susceptibility. We studied 48 Japanese T1D inpatients and revealed associations between DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 haplotypes and complications, offering a new perspective for future research.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 1",
- "HLA-DR3 Antigen",
- "Haplotypes",
- "HLA-DR4 Antigen",
- "Genetic Predisposition to Disease",
"Male",
"Female",
- "Genome-Wide Association Study",
- "Adult"
- ]
+ "Adult",
+ "Diabetic Angiopathies",
+ "Genetic Predisposition to Disease",
+ "Japan",
+ "HLA-DRB1 Chains",
+ "HLA-DQ beta-Chains",
+ "Middle Aged",
+ "Young Adult",
+ "Haplotypes",
+ "Asian People",
+ "Adolescent",
+ "Diabetic Neuropathies",
+ "East Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "3"
+ }
},
{
- "PMID": "39625868",
- "Title": "JMIR mHealth and uHealth",
- "ArticleTitle": "The Role of Smartwatch Technology in the Provision of Care for Type 1 or 2 Diabetes Mellitus or Gestational Diabetes: Systematic Review.",
- "Abstract": "This systematic review has highlighted the lack of robust randomized clinical trials that explore the efficacy of smartwatch technology in the management of patients with type 1, type 2, and gestational diabetes. Further research is required to establish the role of integrated smartwatch technology in important outcomes such as glycemic control, exercise participation, drug adherence, and diet monitoring in people with all forms of diabetes mellitus.",
+ "PMID": "38643555",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Body Mass Index's influence on arterial hypertension in Type 1 diabetes - A brief report from IMI-SOPHIA study.",
+ "Abstract": "Information on BMI and risk of developing hypertension in type 1 diabetes (T1D) is scarce, and it comes mostly from cross-sectional analyses. This study underscores a risk of developing hypertension in T1D individuals with high BMI, and this risk appears to be higher than in those with type 2 diabetes.",
"Predictions": [
"Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Pregnancy",
- "Female",
- "Diabetes, Gestational",
- "Diabetes Mellitus, Type 2",
"Diabetes Mellitus, Type 1",
- "Blood Glucose Self-Monitoring",
- "Wearable Electronic Devices"
- ]
- },
- {
- "PMID": "39625848",
- "Title": "Molecular pharmaceutics",
- "ArticleTitle": "Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights.",
- "Abstract": "Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid modalities, including insulin, which could prove to be beneficial for patients with type 1 diabetes mellitus. This work aimed to design and manufacture a hollow MN with an improved insertion and delivery profile suitable for insulin administration. ",
- "Predictions": [
- "Diabetes type 1"
+ "Hypertension",
+ "Body Mass Index",
+ "Male",
+ "Female",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Diabetic Angiopathies",
+ "Obesity",
+ "Risk Factors",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2"
],
- "MeshTerms": [
- "Insulin",
- "Administration, Cutaneous",
- "Needles",
- "Drug Delivery Systems",
- "Animals",
- "Skin",
- "Swine",
- "Skin Absorption",
- "Microinjections",
- "Diabetes Mellitus, Type 1",
- "Hypoglycemic Agents",
- "Humans"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "22"
+ }
},
{
- "PMID": "39625039",
- "Title": "Annals of the New York Academy of Sciences",
- "ArticleTitle": "Efficacy and safety of the glucagon receptor antagonist volagidemab in type-1 diabetes: A systematic review and meta-analysis.",
- "Abstract": "The glucagon receptor antagonist (GRA) volagidemab is the first-in-class fully human monoclonal antibody that inhibits glucagon receptor. GRA can improve glycemia by reducing endogenous glucose production and reduce risks of diabetic ketoacidosis by suppressing ketogenesis. This systematic review and meta-analysis analyzed the efficacy and safety of volagidemab in type-1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) involving T1D patients receiving volagidemab. The primary outcome was to evaluate changes in total daily dose (TDD) of insulin. The secondary outcomes were to evaluate changes in measures of glycemia, hypoglycemia, and adverse events. Data from 3 RCTs (98 patients) were analyzed. Volagidemab (70\u00a0mg/week) was associated with a significant reduction in TDD of insulin requirement (mean difference [MD]: -8.45 units/day (95% confidence interval [CI]: [-12.09, -4.81]); I",
+ "PMID": "38593490",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Changes in glucometric parameters in people living with diabetes users of the free-style libre 2 system before and after the update possibility to real-time glucose readings in real world practice.",
+ "Abstract": "In Spain, from October 10th, 2023, the FreeStyle Libre 2 system offers the possibility to automatically changed from isCGM to rtCGM with a system update. Our study aimed to evaluate the glucometric before and after that date. We didn't find significant changes in TIR, however time of use increased and TBR decreased.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes",
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 1",
- "Receptors, Glucagon",
- "Hypoglycemic Agents",
+ "Blood Glucose Self-Monitoring",
"Blood Glucose",
- "Insulin",
- "Randomized Controlled Trials as Topic",
- "Hypoglycemia",
- "Treatment Outcome",
- "Antibodies, Monoclonal, Humanized"
- ]
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Spain",
+ "Aged",
+ "Adult",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 1"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "10"
+ }
},
{
- "PMID": "39622650",
- "Title": "JMIR dermatology",
- "ArticleTitle": "Cutaneous Adverse Effects From Diabetes Devices in Pediatric Patients With Type 1 Diabetes Mellitus: Systematic Review.",
- "Abstract": "The dermatologic complications of CGM and CSII pose a potential risk to long-term glycemic control in T1D, especially in young patients where skin lesions can lead to discontinuation. Increased manufacturer transparency is critical and further studies are needed to expand upon the current preventative measures such as device site rotation and steroid creams, which lack consistent effectiveness.",
+ "PMID": "38581085",
+ "Title": "European journal of immunology",
+ "ArticleTitle": "The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.",
+ "Abstract": "We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.",
"Predictions": [
"Diabetes type 1"
],
"MeshTerms": [
- "Humans",
+ "Animals",
+ "Mice",
+ "Cytokines",
"Diabetes Mellitus, Type 1",
- "Child",
- "Blood Glucose Self-Monitoring",
- "Insulin Infusion Systems",
- "Adolescent",
- "Insulin",
- "Skin Diseases",
- "Hypoglycemic Agents",
- "Child, Preschool",
- "Lipodystrophy",
- "Dermatitis, Contact"
- ]
+ "Glycolysis",
+ "Histones",
+ "Inflammation",
+ "Macrophages",
+ "Mice, Inbred BALB C",
+ "Mice, Inbred NOD",
+ "Phenotype",
+ "Helminth Proteins"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "6"
+ }
},
{
- "PMID": "39622257",
- "Title": "The lancet. Diabetes & endocrinology",
- "ArticleTitle": "Treatment regimens and glycaemic outcomes in more than 100\u2009000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from paediatric diabetes registries.",
- "Abstract": "For the Norwegian, German, Czech, Danish and Swedish translations of the abstract see Supplementary Materials section.",
+ "PMID": "38557767",
+ "Title": "Abdominal radiology (New York)",
+ "ArticleTitle": "Cross-sectional imaging of the pancreas in diabetes.",
+ "Abstract": "Diabetes mellitus presents a global health challenge characterized by dysregulated glucose metabolism and insulin resistance. Pancreas dysfunction contributes to the development and progression of diabetes. Cross-sectional imaging modalities have provided new insight into the structural and functional alterations of the pancreas in individuals with diabetes. This review summarizes MRI and CT studies that characterize pancreas alterations in both type 1 and type 2 diabetes and discusses future applications of these techniques.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Magnetic Resonance Imaging",
+ "Tomography, X-Ray Computed",
+ "Pancreas",
+ "Diabetes Mellitus, Type 2",
"Diabetes Mellitus, Type 1",
- "Registries",
- "Child",
- "Female",
- "Male",
- "Longitudinal Studies",
- "Adolescent",
- "Child, Preschool",
- "Glycated Hemoglobin",
- "Hypoglycemic Agents",
- "Blood Glucose",
- "Hypoglycemia",
- "Treatment Outcome",
- "Infant",
- "Glycemic Control"
- ]
- },
- {
- "PMID": "39622163",
- "Title": "Biofabrication",
- "ArticleTitle": "Engineering pore-enriched and pre-vascularized volumetric constructs for enhanced blood glucose regulation in type 1 diabetes therapy.",
- "Abstract": "Managing type 1 diabetes mellitus (T1DM) presents significant challenges because of the complexity of replicating the microenvironment of pancreatic islets and ensuring the long-term viability and function of transplanted insulin-producing cells (IPCs). This study developed a functional approach that utilizes 3D bioprinting technology to create pore-enriched and pre-vascularized tissue constructs incorporating a pancreatic tissue-derived decellularized extracellular matrix and human-induced pluripotent stem cells (hiPSCs) aimed at enhancing blood glucose regulation in T1DM. We designed a volumetric 3D pancreatic tissue construct that supported the engraftment, survival, and insulin-producing functionality of hiPSC-derived IPCs. The construct's porosity was optimized to enhance IPC delivery efficiency. Additionally, human umbilical vein endothelial cells co-cultured with IPCs in a patterned structure facilitated pre-vascularization, improving construct integration with host tissues and accelerating revascularization post-transplantation. Our results demonstrate high cell viability and sustained insulin production in diabetic rodent models, indicating the constructs' effectiveness in regulating blood glucose levels over an extended period. The findings of this study not only underscore the potential of 3D bioprinting for creating functional tissue constructs for T1DM treatment but also offer efficient cell delivery techniques applicable to other areas of regenerative medicine.",
- "Predictions": [
- "Diabetes type 1"
+ "Pancreatic Diseases"
],
- "MeshTerms": [
- "Diabetes Mellitus, Type 1",
- "Humans",
- "Animals",
- "Blood Glucose",
- "Tissue Engineering",
- "Porosity",
- "Human Umbilical Vein Endothelial Cells",
- "Tissue Scaffolds",
- "Induced Pluripotent Stem Cells",
- "Insulin",
- "Diabetes Mellitus, Experimental",
- "Printing, Three-Dimensional",
- "Bioprinting",
- "Male",
- "Cell Survival",
- "Insulin-Secreting Cells",
- "Extracellular Matrix"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "1"
+ }
},
{
- "PMID": "39621933",
- "Title": "Diabetes care",
- "ArticleTitle": "Continuous Glucose Monitor Accuracy for Diabetes Management in Hospitalized Children.",
- "Abstract": "CGMs demonstrated acceptable accuracy in hospitalized children with diabetes. CGM data should be integrated into hospital electronic records to optimize management.",
+ "PMID": "38448275",
+ "Title": "British journal of anaesthesia",
+ "ArticleTitle": "Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction.",
+ "Abstract": "The now-routine clinical deployment of continuous glucose monitoring has demonstrated benefit in real-world settings. We make the case that continuous glucose monitoring can help re-examine, at scale, the role that (stress) hyperglycaemia plays in fuelling organ dysfunction after tissue trauma. Provided robust perioperative data do emerge, well-established continuous glucose monitoring technology could soon help transform the perioperative landscape.",
"Predictions": [
- "Diabetes",
"Diabetes type 1"
],
"MeshTerms": [
"Humans",
- "Child",
- "Adolescent",
- "Child, Preschool",
- "Retrospective Studies",
- "Female",
"Blood Glucose",
- "Male",
"Blood Glucose Self-Monitoring",
- "Diabetes Mellitus",
- "Hospitalization",
+ "Continuous Glucose Monitoring",
+ "Multiple Organ Failure",
+ "Hyperglycemia",
"Diabetes Mellitus, Type 1"
- ]
- },
- {
- "PMID": "39621313",
- "Title": "The Journal of clinical investigation",
- "ArticleTitle": "Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice.",
- "Abstract": "Type 1 diabetes (T1D) develops spontaneously despite functional antigen presentation machinery in the thymus and a perceptible central tolerance process. We found that intrathymic enrichment with IL-4 fine tunes signaling through the IL-4/IL-13 heteroreceptor (HR) in early thymic progenitors (ETPs), augments negative selection of self-reactive T cells, sustains a diverse T cell repertoire devoid of clones expressing disease-associated T cell receptor (TCR) genes, and protects the nonobese diabetic (NOD) mouse from T1D. Indeed, optimal IL-4 activates STAT transcription factors to program ETP fate decision toward CD11c+CD8\u03b1+ dendritic cells (DCs) agile in negative T cell selection and clonal deletion of diabetogenic T cells. However, due to diminished invariant natural killer T (iNKT) 2 cell frequency in the NOD thymus, IL-4 is as suboptimal level, metering STAT activation to program ETP fate decision toward the T cell lineage leading to diminished negative selection, a clonally restricted TCR repertoire, and manifestation of spontaneous T1D. These insights uncover yet another interplay by which IL-4 affects T1D.",
- "Predictions": [
- "Diabetes type 1"
],
- "MeshTerms": [
- "Animals",
- "Mice, Inbred NOD",
- "Interleukin-4",
- "Mice",
- "Thymus Gland",
- "Diabetes Mellitus, Type 1",
- "Receptors, Antigen, T-Cell",
- "Dendritic Cells",
- "Natural Killer T-Cells"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "7"
+ }
},
{
- "PMID": "39620918",
- "Title": "Diabetes technology & therapeutics",
- "ArticleTitle": "Automated Insulin Delivery Effects During Driving Among Older Adults with Type 1 Diabetes in a Randomized Trial.",
- "Abstract": "Dysglycemia among drivers with type 1 diabetes (T1D) is associated with impaired driving performance, and glucose levels \"above 5 to drive\" are often recommended for insulin-treated drivers. Evidence for diabetes treatments that support euglycemia while driving is minimal, particularly for older drivers. In this randomized, crossover trial involving adults aged \u226560 years with T1D, we used continuous glucose monitoring (CGM) during driving to compare the first-generation closed-loop automated insulin delivery (AID) versus a sensor-augmented pump therapy. There were 1894 trips undertaken by 8 drivers (median age 68 years [IQR: 64-70]). During AID versus sensor-augmented pump, time in range >5.0-10.0 mmol/L was greater (100% [0-100] vs. 81% [0-100]; ",
+ "PMID": "38403174",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Effect of low dose Semaglutide in people with Type 1 Diabetes and excess weight.",
+ "Abstract": "Obesity is a prevalent problem in people living with T1D (PwT1D), and it has been linked to cardiovascular disease in this population. The use of low dose weekly Semaglutide (0,5 mg) was evaluated in a cohort of PwT1D and excess weight.",
"Predictions": [
- "Diabetes type 1"
+ "Diabetes type 1",
+ "Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 1",
- "Aged",
- "Automobile Driving",
- "Insulin Infusion Systems",
- "Male",
- "Female",
- "Insulin",
- "Cross-Over Studies",
"Hypoglycemic Agents",
- "Middle Aged",
- "Blood Glucose",
- "Blood Glucose Self-Monitoring"
- ]
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Glucagon-Like Peptides",
+ "Weight Gain",
+ "Glucagon-Like Peptide-1 Receptor"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "2",
+ "Day": "26"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/diabetes_type_2.json b/testModel/dataset/diabetes_type_2.json
index d12573feb..2a9c63ad7 100644
--- a/testModel/dataset/diabetes_type_2.json
+++ b/testModel/dataset/diabetes_type_2.json
@@ -25,61 +25,12 @@
"Comorbidity",
"Obesity",
"Snoring"
- ]
- },
- {
- "PMID": "39737893",
- "Title": "Nutrition & diabetes",
- "ArticleTitle": "The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.",
- "Abstract": "There is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.",
- "Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Mendelian Randomization Analysis",
- "Male",
- "Female",
- "Nutrition Surveys",
- "Middle Aged",
- "Genome-Wide Association Study",
- "Arthritis, Rheumatoid",
- "Adult",
- "Arthritis",
- "Prevalence",
- "Diabetes Mellitus, Type 2",
- "Diabetes Mellitus, Type 1",
- "Aged",
- "Genetic Predisposition to Disease",
- "Logistic Models",
- "Polymorphism, Single Nucleotide"
- ]
- },
- {
- "PMID": "39737509",
- "Title": "The Indian journal of medical research",
- "ArticleTitle": "ICMR-MDRF Diabetes Biosamples: Cohort profile.",
- "Abstract": "Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR). The ICMR-INDIAB study is the largest epidemiological study on diabetes in India, encompassing a nationally representative sample of individuals aged 20 yr and older from urban and rural areas in every State across the country. The ICMR-YDR is the first national-level, multicentric clinic-based registry focusing on youth-onset diabetes in India, aiming to understand the disease patterns and variations in youth-onset diabetes across different country regions. Results Key operations at the MDRF biobank include collecting and processing samples, where serum and whole blood samples are aliquoted and transferred through a cold chain to the central laboratory, and then stored in Siruseri (29 km from the capital city of Chennai, Tamil Nadu). Samples are barcoded, linked to subject information, and stored in freezers or liquid nitrogen (LN2) vessels, with inventory tracked via software for easy retrieval. A register records access to the biobank, ensuring sample integrity and compliance with regulatory requirements. The biobank adheres to the ICMR's National Ethical Guidelines for Biomedical and Health Research involving human participants. Interpretation & conclusions The biobank enables the analysis of biomarkers in stored samples, aiding in scientifically sound decisions, treating patients, and potentially curing diabetes.",
- "Predictions": [
- "Diabetes",
- "Diabetes type 2"
],
- "MeshTerms": [
- "Humans",
- "India",
- "Biological Specimen Banks",
- "Adult",
- "Female",
- "Male",
- "Diabetes Mellitus",
- "Registries",
- "Biomedical Research",
- "Young Adult",
- "Cohort Studies",
- "Age of Onset",
- "Diabetes Mellitus, Type 2"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736941",
@@ -103,13 +54,18 @@
"Dietary Supplements",
"Random Allocation",
"Streptozocin"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736870",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Construction and validation of a nomogram model for predicting diabetic peripheral neuropathy.",
- "Abstract": "The DPN nomogram prediction model, containing 7 significant variables, has exhibited excellent performance. Its generalization to clinical practice could potentially help in the early detection and prompt intervention for high-risk DPN patients.",
+ "Abstract": "Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes that can potentially escalate into ulceration, amputation and other severe consequences. The aim of this study was to construct and validate a predictive nomogram model for assessing the risk of DPN development among diabetic patients, thereby facilitating the early identification of high-risk DPN individuals and mitigating the incidence of severe outcomes.1185 patients were included in this study from June 2020 to June 2023. All patients underwent peripheral nerve function assessments, of which 801 were diagnosed with DPN. Patients were randomly divided into a training set (n =711) and a validation set (n = 474) with a ratio of 6:4. The least absolute shrinkage and selection operator (LASSO) logistic regression analysis was performed to identify independent risk factors and develop a simple nomogram. Subsequently, the discrimination and clinical value of the nomogram was extensively validated using receiver operating characteristic (ROC) curves, calibration curves and clinical decision curve analyses (DCA).Following LASSO regression analysis, a nomogram model for predicting the risk of DPN was eventually established based on 7 factors: age (OR = 1.02, 95%CI: 1.01 - 1.03), hip circumference (HC, OR = 0.94, 95%CI: 0.92 - 0.97), fasting plasma glucose (FPG, OR = 1.06, 95%CI: 1.01 - 1.11), fasting C-peptide (FCP, OR = 0.66, 95%CI: 0.56 - 0.77), 2 hour postprandial C-peptide (PCP, OR = 0.78, 95%CI: 0.72 - 0.84), albumin (ALB, OR = 0.90, 95%CI: 0.87 - 0.94) and blood urea nitrogen (BUN, OR = 1.08, 95%CI: 1.01 - 1.17). The areas under the curves (AUC) of the nomogram were 0.703 (95% CI 0.664-0.743) and 0.704 (95% CI 0.652-0.756) in the training and validation sets, respectively. The Hosmer-Lemeshow test and calibration curves revealed high consistency between the predicted and actual results of the nomogram. DCA demonstrated that the nomogram was valuable in clinical practice.The DPN nomogram prediction model, containing 7 significant variables, has exhibited excellent performance. Its generalization to clinical practice could potentially help in the early detection and prompt intervention for high-risk DPN patients.",
"Predictions": [
"Diabetes type 2"
],
@@ -126,33 +82,12 @@
"Diabetes Mellitus, Type 2",
"Prognosis",
"Adult"
- ]
- },
- {
- "PMID": "39736865",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus - an exploratory study.",
- "Abstract": "Both T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.",
- "Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
],
- "MeshTerms": [
- "Humans",
- "Male",
- "Female",
- "Ultrasonography",
- "Aged",
- "Middle Aged",
- "Bone Density",
- "Diabetes Mellitus, Type 2",
- "Tibia",
- "Absorptiometry, Photon",
- "Case-Control Studies",
- "Diabetes Mellitus, Type 1",
- "Cortical Bone",
- "Elasticity"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736861",
@@ -169,41 +104,18 @@
"Hyperparathyroidism, Primary",
"Adrenal Glands",
"Diabetes Mellitus, Type 2"
- ]
- },
- {
- "PMID": "39736858",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018.",
- "Abstract": "Adherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.",
- "Predictions": [
- "Cardiovascular diseases",
- "Diabetes type 2"
],
- "MeshTerms": [
- "Humans",
- "Diabetes Mellitus, Type 2",
- "Cardiovascular Diseases",
- "Male",
- "Female",
- "Middle Aged",
- "Nutrition Surveys",
- "Adult",
- "Oxidative Stress",
- "United States",
- "Aged",
- "Life Style",
- "Diet",
- "Risk Factors",
- "Follow-Up Studies",
- "Prevalence"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736551",
"Title": "BMC primary care",
"ArticleTitle": "The moderating role of e-health literacy and patient-physician communication in the relationship between online diabetes information-seeking behavior and self-care practices among individuals with type 2 diabetes.",
- "Abstract": "Findings support the role of patient eHL and patient-physician communication in amplifying the positive impact of online DISB on patients' behavioral outcomes in diabetes.",
+ "Abstract": "This study examined the moderating role of e-health literacy (eHL) and patient-physician communication in the relationship between online diabetes information-seeking behavior (online DISB) and self-care practices.A total of 1143 individuals with type 2 diabetes mellitus completed a cross-sectional survey assessing sociodemographic characteristics, data relating to diabetes clinical history, online DISB, eHL (eHealth Literacy Scale), aspects of patient-physician communication (IPC survey), patient self-care (Self-Care Inventory-Revised), and medication adherence (measure of adherence to prescribed diabetes medications). The data were analyzed using both bivariate (correlation)\u00a0and multivariate (multiple linear regression) analyses using maximum likelihood estimation procedures in Mplus.Our results showed online DISB significantly predicted diabetes self-care (p\u2009<\u20090.001) and medication adherence behaviors (p\u2009=\u20090.005). Lower Hurried Communication (p\u2009<\u20090.001, p\u2009=\u20090.03), higher Elicited Concerns (p\u2009=\u20090.005, p\u2009=\u20090.03), higher Explained Results (p\u2009=\u20090.03, p\u2009=\u20090.008), and higher eHL (p\u2009=\u20090.02, p\u2009=\u20090.02) were significantly associated with better self-care and medication adherence. Explained Results and eHL moderated the relationship between online DISB and both self-care and medication adherence.Findings support the role of patient eHL and patient-physician communication in amplifying the positive impact of online DISB on patients' behavioral outcomes in diabetes.",
"Predictions": [
"Diabetes type 2"
],
@@ -224,13 +136,18 @@
"Adult",
"Internet",
"Assessment of Medication Adherence"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736518",
"Title": "BMC cardiovascular disorders",
"ArticleTitle": "Effect of sodium glucose cotransporter-2 inhibitors (SGLT-2is) on the clinical outcomes of patients with diabetic atrial fibrillation.",
- "Abstract": "In our study, SGLT-2i treatment was associated with a significant reduction in all-cause mortality and major bleeding in diabetic AF patients. Our study provides evidence of the clinical benefit of SGLT-2i in AF patients.",
+ "Abstract": "Diabetes mellitus (DM) and atrial Fibrillation (AF) are among the most common health issues. They are responsible for the highest rates of morbidity and mortality. The importance of sodium glucose cotransporter-2 inhibitors (SGLT-2is) in treating DM has increased significantly in recent years. In our article, we aimed to evaluate the effect of SGLT-2i on the clinical outcomes of AF patients with DM.Our study is a retrospective, observational study. The patients with AF and DM were divided into two groups: those using SGLT-2i or not using SGLT-2i, and 3-year follow-up results were examined. The endpoints of the study were defined as all-cause death, the development of myocardial infarction (MI), major bleeding requiring hospitalization, and an ischemic cerebrovascular event (CVE). Differences between groups according to SGLT-2i use were analyzed.The study included 485 patients, 205 (42.3%) of whom were male and had an average age of 70.7\u2009\u00b1\u20099.7 years. A total of 138 of 485 patients (28.5%) received SGLT-2i. All-cause mortality was lower in the group receiving SGLT-2i (p\u2009<\u20090.001). Similarly, a significant reduction in major bleeding events was observed among those who received SGLT-2i treatment (p\u2009=\u20090.009). The incidence of CVEs was lower among SGLT-2i recipients, but the difference was not statistically significant (p\u2009=\u20090.066). SGLT2i usage did not mitigate the risk of MI development (p\u2009=\u20090.317).In our study, SGLT-2i treatment was associated with a significant reduction in all-cause mortality and major bleeding in diabetic AF patients. Our study provides evidence of the clinical benefit of SGLT-2i in AF patients.",
"Predictions": [
"Diabetes type 2"
],
@@ -252,13 +169,18 @@
"Aged, 80 and over",
"Cause of Death",
"Myocardial Infarction"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736351",
"Title": "Life sciences",
"ArticleTitle": "AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.",
- "Abstract": "In conclusion, we have developed a novel strategy for producing long-acting FGF21 using the AAV vector, and AAV2-ABD-FGF21 shows promise as a therapeutic approach for type 2 diabetes mellitus and other glycolipid metabolic disorders.",
+ "Abstract": "Fibroblast Growth Factor 21 (FGF21) is a naturally occurring peptide hormone involved in the regulation of glycolipid metabolism, and it shows promise as a potential treatment for type 2 diabetes mellitus (T2DM). However, the short half-life and poor pharmacokinetics of native FGF21 limit its efficacy in reducing hyperglycemia in vivo. Therefore, maintaining stable and sustained blood concentrations of FGF21 is crucial for its role as an effective regulator of glycolipid metabolism in vivo. In this study, we developed an AAV2-mediated gene delivery system incorporating an Albumin-binding domain (ABD) fused to FGF21, and we evaluated its effects in a type 2 diabetic mouse model.The plasmids pAAV-FGF21-Luciferase, pHelper, and the capsid plasmid were transfected into HEK293T cells to generate recombinant AAV (rAAV) virus. A type 2 diabetes mellitus (T2DM) mouse model was established for evaluation. The rAAV was administered via tail vein injection into the mice. The effects of rAAV injection on various parameters were assessed using commercial kits. Histological changes in the liver and adipose tissue of T2DM mice were examined using hematoxylin and eosin (H&E) staining.The data showed that the inclusion of ABD significantly prolonged the half-life of FGF21 in the serum of mice. Additionally, AAV2-mediated delivery of ABD-FGF21 to the liver resulted in sustained gene expression and a significant increase in circulating FGF21 levels in mice. Treatment with AAV2-ABD-FGF21 led to several benefits, including reduced fasting glucose, improved insulin sensitivity, decreased triglyceride and total cholesterol levels, and improved body weight in T2DM mice. Furthermore, serum analysis and histological examination showed no significant liver damage at the study endpoint after seven weeks.In conclusion, we have developed a novel strategy for producing long-acting FGF21 using the AAV vector, and AAV2-ABD-FGF21 shows promise as a therapeutic approach for type 2 diabetes mellitus and other glycolipid metabolic disorders.",
"Predictions": [
"Diabetes type 2"
],
@@ -279,13 +201,18 @@
"Genetic Vectors",
"Liver",
"Hypoglycemic Agents"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736334",
"Title": "Diabetes research and clinical practice",
"ArticleTitle": "Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets.",
- "Abstract": "Adhered to a balanced diet is associated with a lower risk of diabetes compared to plant-based diet, which might be attributed to signature proteins such as AGR2, DBI, IL17RA and SERPINH1.",
+ "Abstract": "Plant-based diets benefit human health, while the deficient in some nutrients limits its application. We aimed to examine whether balanced diets could be better in reducing diabetes risk than plant-based diets.In cross-sectional analysis of Environment-Inflammation-Metabolic-Diseases Study (EIMDS), we used a questionnaire to investigate the habit of balanced and plant-based diets. In the prospective analysis of UK Biobank, we used the plant-based diet index of health (hPDI) and unhealth (uPDI) to evaluate the plant-based diets, and defined the balanced diet as a daily intake of 5 categories and at least 12 types of food. After analyzing proteomic data in UK Biobank, we explored the causal relationship between signature proteins of balanced diets and incident diabetes based on summary-data-based Mendelian randomization (SMR).Compared to participants who had plant-based diets, those who had balanced diets showed a lower risk of diabetes in EIMDS (Odd Ratio 0.65, 95%CI 0.44-0.95). In UK Biobank, after excluding participants with unhealthy plant-based diets, participants with balanced diets still showed a lower diabetes risk than participants with plant-based diets (Hazard Ratio 0.86, 95%CI 0.77-0.95). Proteomic analysis identified 107 downregulated and 2 upregulated proteins that were associated with higher and lower risk of diabetes, respectively. In SMR analyses, the downregulated signature proteins of balanced diets (AGR2, DBI, IL17RA and SERPINH1) were causally associated with diabetes incidence.Adhered to a balanced diet is associated with a lower risk of diabetes compared to plant-based diet, which might be attributed to signature proteins such as AGR2, DBI, IL17RA and SERPINH1.",
"Predictions": [
"Diabetes type 2"
],
@@ -305,13 +232,49 @@
"Proteomics",
"Diet, Healthy",
"Diet, Plant-Based"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39736252",
+ "Title": "Computers in biology and medicine",
+ "ArticleTitle": "Proteomic analysis of the effects of Girdin on Jiaogulan-treated type 2 diabetes patients.",
+ "Abstract": "Jiaogulan (Gynostemma pentaphyllum) is a traditional herb with potential antidiabetic properties. This study investigated the underlying mechanisms of these properties by analysing plasma protein profiles in type 2 diabetes patients. A total of 42 participants were divided into three groups, each comprising 14 individuals: healthy controls (N), untreated type 2 diabetes patients (DM), and Jiaogulan-treated type 2 diabetes patients (DMJ). Proteomic analysis, integrated with bioinformatics and molecular docking, was conducted. This analysis identified 24 unique proteins in the healthy control group, 16 in the untreated diabetic group, and 19 in the Jiaogulan-treated group. Notably, the Jiaogulan-treated group exhibited statistically significant upregulation of proteins involved in insulin signalling, including CCDC88A (Girdin), with a p value of <0.05. This protein is a critical regulator of insulin sensitivity that interacts with the Akt and PI3K pathways. Furthermore, molecular docking analysis identified gypenoside, a bioactive compound from Jiaogulan, as a potential inhibitor of protein phosphatase 2A (PP2A), an important regulator of insulin signalling. PP2A inhibition preserves the phosphorylation of critical signalling molecules, such as Akt, facilitating glucose uptake and metabolism. These findings suggest that Jiaogulan may increase insulin sensitivity by modulating key proteins in the insulin signalling pathway, such as Girdin, and inhibiting PP2A activity. This inhibition might help maintain the phosphorylation of critical signalling molecules such as Akt, thereby promoting glucose uptake and metabolism. Ultimately, this research suggests that Jiaogulan has significant potential therapeutic benefits for individuals with type 2 diabetes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Proteomics",
+ "Gynostemma",
+ "Molecular Docking Simulation",
+ "Microfilament Proteins",
+ "Vesicular Transport Proteins",
+ "Plant Extracts",
+ "Hypoglycemic Agents",
+ "Proteome",
+ "Signal Transduction",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39736162",
"Title": "West African journal of medicine",
"ArticleTitle": "The Impact of Diabetes Self-Management Education (DSME) on the Quality of Life of patients living with type-2 Diabetes Mellitus in Nigeria.",
- "Abstract": "The findings highlight that DSME significantly enhances the QoL, self-management competence, and glycemic control among T2DM patients in Nigeria. These results underscore the importance of structured educational interventions in diabetes care, particularly in resource-limited settings.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) significantly affects the quality of life (QoL), necessitating comprehensive management strategies. In resource-limited settings such as Nigeria, managing diabetes can be challenging due to limited access to medications, which impacts patients' QoL. Diabetes Self-Management Education (DSME) empowers patients through knowledge and skills, potentially improving their QoL. This study aimed to assess the impact of DSME on the QoL of T2DM patients in Nigeria.A quasi-experimental (pre-test and post-test) design was employed at the Olabisi Onabanjo University Teaching Hospital in Nigeria. Adult patients with uncomplicated T2DM who regularly attended the diabetic clinic were systematically sampled. Data was collected using a structured questionnaire covering demographics, QoL, self-monitoring knowledge, and self-management competence. A DSME program, including modules on nutrition, exercise, and foot care, was implemented. Pre- and post-intervention measurements were taken, and the data was analyzed.The study revealed significant improvements in all QoL domains after the DSME intervention, including physical functioning, role-physical, bodily pain, general health, social functioning, role-emotional, and mental health (p<0.001 for most domains). Postintervention, self-management competence scores showed a significant increase (mean difference: -9.655, p<0.001), and fasting blood glucose levels decreased significantly following DSME (mean difference: 14.897 mg/dL, p<0.001). Multivariate regression analysis demonstrated that DSME significantly enhanced post-intervention QoL scores (coefficient: 3.5054, p=0.001). Higher baseline QoL and education levels were positively associated with better outcomes.The findings highlight that DSME significantly enhances the QoL, self-management competence, and glycemic control among T2DM patients in Nigeria. These results underscore the importance of structured educational interventions in diabetes care, particularly in resource-limited settings.",
"Predictions": [
"Diabetes type 2"
],
@@ -330,13 +293,18 @@
"Health Knowledge, Attitudes, Practice",
"Aged",
"Self Care"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735994",
"Title": "Frontiers in bioscience (Landmark edition)",
"ArticleTitle": "The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples.",
- "Abstract": "The study demonstrates a decrease in ",
+ "Abstract": "Epidermal growth factor receptor 4 (ERBB4) and neuregulin 4 (NRG4) have been shown to reduce steatosis and prevent the development of non-alcoholic steatohepatitis in mouse models, but little to nothing is known about their role in non-alcoholic fatty liver disease (NAFLD) in humans. This study is the first to investigate the expression of and mRNAs and their role in lipid metabolism in the livers of individuals with obesity, type 2 diabetes and biopsy-proven NAFLD.Liver biospecimens were obtained intraoperatively from 80 individuals. Quantitative reverse transcription polymerase chain reaction was used to measure the expression levels of mRNAs and , as well as key lipogenesis genes in the liver tissue of the donors. Histological analysis was conducted on liver biopsies from 36 subjects, and the levels of the examined transcripts were compared with the stage of NAFLD.In individuals with elevated body mass index (BMI), and levels decreased, while levels increased. A strong negative correlation was observed between and levels. No deregulation of the analyzed transcripts was detected in NAFLD.The study demonstrates a decrease in and mRNA expression in the livers of subjects with high BMI but not in those with NAFLD. The correlation of the studied transcripts with major lipogenesis genes was assessed, and on this basis a putative scheme for NRG4-mediated suppression of hepatic lipogenesis was hypothesised, offering new research vectors in this field.",
"Predictions": [
"Diabetes type 2"
],
@@ -355,7 +323,12 @@
"Diabetes Mellitus, Type 2",
"RNA, Messenger",
"Aged"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735781",
@@ -378,13 +351,18 @@
"Risk Factors",
"Bone Density",
"Postmenopause"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735651",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Association between changes in thyroid hormones and incident type 2 diabetes using joint models of longitudinal and time-to-event data: more than a decade follow up in the Tehran thyroid study.",
- "Abstract": "The findings of this study suggest that dynamic changes in serum thyroid hormones are associated with the development of T2DM. Rising TSH and decreasing FT4 over time are associated with a lower risk of diabetes. These findings suggest a complex interplay between thyroid function and the risk of T2DM, emphasizing the importance of monitoring thyroid hormone levels as a part of T2DM prevention strategies.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) poses a significant public health challenge, contributing to considerable morbidity and mortality worldwide, which necessitates urgent preventive measures. Thyroid disorders, prevalent in many individuals, are intricately linked to metabolic health, yet studies on their relationship with T2DM yield inconsistent results-some suggesting an increased risk with abnormal thyroid hormone levels, while others indicate potential protective effects. This study investigated the association between changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels and the incidence of type 2 diabetes mellitus.Data from 1938 individuals aged \u226520 in the Tehran Thyroid Study cohort were used, spanning four examination cycles from 1999 to 2012, with three-year intervals. TSH and FT4 levels were log-transformed and modeled as time-varying exposures to study their association with incident T2DM.During a median follow-up of 9.43 years, 135 new T2DM cases were identified. The multivariable-adjusted joint model (JM) revealed that each unit increase in log-transformed TSH level was associated with a 25% decrease in T2DM incidence [HRs (95% CI): 0.75 (0.64-0.90)]. Conversely, each unit increase in FT4 level showed a marginally significant higher risk [1.06 (0.99-1.13); p-value=0.06].The findings of this study suggest that dynamic changes in serum thyroid hormones are associated with the development of T2DM. Rising TSH and decreasing FT4 over time are associated with a lower risk of diabetes. These findings suggest a complex interplay between thyroid function and the risk of T2DM, emphasizing the importance of monitoring thyroid hormone levels as a part of T2DM prevention strategies.",
"Predictions": [
"Diabetes type 2"
],
@@ -406,7 +384,12 @@
"Thyroid Function Tests",
"Thyroid Gland",
"Thyroid Diseases"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735647",
@@ -422,7 +405,12 @@
"Diabetes Mellitus, Type 2",
"Gastrointestinal Microbiome",
"Animals"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735646",
@@ -441,13 +429,18 @@
"Algorithms",
"Hypoglycemic Agents",
"Diabetes Mellitus, Type 2"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735639",
"Title": "Frontiers in endocrinology",
"ArticleTitle": "Association of circulating adiponectin and leptin levels with the risk of diabetic peripheral neuropathy.",
- "Abstract": "Circulating adiponectin and leptin levels correlate with DPN risk in diabetic patients, suggesting their potential as biomarkers for high-risk DPN identification and guiding targeted prevention and management.",
+ "Abstract": "Adipokines have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and related complications due to their roles in metabolic regulation and inflammation. However, the relationship between these adipokines and diabetic peripheral neuropathy (DPN) remains unclear.A case-control study was performed with 198 patients with DPN and 205 T2DM patients without DPN from the Endocrinology Department at the Second Affiliated Hospital of Hainan Medical University. Circulating adiponectin and leptin levels were quantified via enzyme-linked immunosorbent assays. Logistic regression models, adjusting for age, sex, BMI, smoking status, and diabetes duration, were applied to evaluate the associations between adiponectin and leptin levels and DPN risk.DPN patients exhibited lower adiponectin (P=0.001) and higher leptin (P=0.007) levels than diabetic controls. Confounders-adjusted analyses revealed that higher adiponectin levels correlated with reduced DPN risk (OR, tertile 3 vs. tertile 1: 0.52; 95% CI: 0.30-0.90), whereas elevated leptin levels were linked to increased DPN risk (OR, tertile 3 vs. tertile 1: 1.91; 95% CI: 1.10-3.32). Stratified analyses confirmed consistent findings across subgroups without statistically significant interactions.Circulating adiponectin and leptin levels correlate with DPN risk in diabetic patients, suggesting their potential as biomarkers for high-risk DPN identification and guiding targeted prevention and management.",
"Predictions": [
"Diabetes type 2"
],
@@ -465,15 +458,18 @@
"Biomarkers",
"Risk Factors",
"Adult"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735416",
"Title": "Journal of diabetes research",
"ArticleTitle": "Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers and Predictive Risk Factors for Lower Limb Amputation: A Population-Based Retrospective Study.",
- "Abstract": {
- "b": "Conclusion:"
- },
+ "Abstract": "Limited data are available about the epidemiological characteristics and the risk factors for amputation, particularly in developing countries from Asia, especially in China. We aim to investigate the age features of patients with Type 2 diabetic foot ulcers (DFUs) and analyze the critical influencing factors predicting lower extremity amputation and major amputation. Data were retrieved from the electric medical record system to identify patients aged >\u200918 years with Type 2 DFU from January 1, 2017, to December 31, 2023. A logistic regression model was adopted to analyze the risk factors for amputation and major amputation. Nine hundred eighteen patients with Type 2 DFU were eligible for our study, 68.2% of whom were male. In patients with Type 2 diabetes in the hospitals we studied, the prevalence of Type 2 DFU was 1.07%. A majority of patients with DFU were in the 70-79 age group in the winter season, and deaths also peaked in this age group. A total of 38.8% of patients aged 50-59 years underwent amputation. Vascular CTA, complications, history of amputation, and infection sites were the important contributing factors in patients with DFU lower extremity amputation. History of amputation and hemoglobin were the main influencing factors of patients with major amputation resulting from DFU. Most patients with DFU were in the age group of 50-59 years, but the majority of deaths occurred in the 70-79-year age group. Several factors influence the amputation, and those findings provide new insights into the relationship between the severity of narrowed blood vessels and the likelihood of amputation.",
"Predictions": [
"Diabetes type 2"
],
@@ -494,15 +490,18 @@
"Adult",
"Prevalence",
"Aged, 80 and over"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735415",
"Title": "Journal of diabetes research",
"ArticleTitle": "Metabolomic Profiling Reveals Biomarkers in Coronary Heart Disease Comorbidity.",
- "Abstract": {
- "b": "Conclusion:"
- },
+ "Abstract": "Coronary heart disease (CHD), hypertension (HTN), depression (Dep), and Type 2 diabetes mellitus (T2DM) are often comorbid, resulting in an exacerbated patient condition and worsened prognosis. A lack of systematic metabolomic studies on comorbidities of CHD remains. Therefore, comprehensive metabolomic-based evaluation of comorbidities of CHD is necessary. In the current study, 169 healthy subjects, 149 CHD subjects, 107 CHD\u2009+\u2009HTN subjects, 126 CHD\u2009+\u2009Dep subjects, and 58 CHD\u2009+\u2009T2DM subjects were recruited. Gas chromatography-mass spectrometry was used for metabolite determination, and multivariate statistical analysis was conducted to identify metabolites that are differentially expressed with the comorbidities of CHD. There were 9, 16, 14, and 10 metabolites identified in the healthy and CHD group, the CHD and CHD\u2009+\u2009HTN group, the CHD and CHD\u2009+\u2009Dep group, and the CHD and CHD\u2009+\u2009T2DM group, respectively. Six metabolic pathways were affected, involving starch and sucrose metabolism; fructose and mannose metabolism; citrate cycle; alanine, aspartate, and glutamate metabolism; fatty acid biosynthesis; and glycolysis. Our study has systematically elucidated the metabolic changes underlying the comorbidities of CHD, thereby providing insight into the mechanisms associated with these alterations.",
"Predictions": [
"Diabetes type 2"
],
@@ -523,15 +522,18 @@
"Metabolome",
"Adult",
"Case-Control Studies"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735414",
"Title": "Journal of diabetes research",
"ArticleTitle": "Olfactory Dysfunction as a Biomarker for Early Diagnosis of Cognitive Impairment in Patients With Type 2 Diabetes: A Systematic Review.",
- "Abstract": {
- "b": "Conclusions:"
- },
+ "Abstract": "Olfactory dysfunction and cognitive impairment (CI) have been associated with Type 2 diabetes (T2DM), but the mechanisms underlying this association are broadly unknown. This systematic review tends to investigate the relationship between the onset of olfactory dysfunction and CI in patients with T2DM and to explore the potential role of olfactory dysfunction as an early diagnosis biomarker of CI. We conducted a systematic review consulting PubMed and Scopus. The articles considered eligible included patients with T2DM and cognitive and olfactory test. The search identified a total of 145 articles, of which 13 were finally selected. The majority of these studies discovered a correlation between olfactory dysfunction and CI in individuals with T2DM. Additionally, other biomarkers such as functional magnetic resonance imaging demonstrated changes in brain regions associated with the sense of smell in T2DM patients. Olfactory dysfunction could be a biomarker for early diagnosis of CI in T2DM. However, these alterations are highly heterogeneous and more studies that include neuroimaging need to be conducted.",
"Predictions": [
"Diabetes type 2"
],
@@ -545,13 +547,18 @@
"Smell",
"Magnetic Resonance Imaging",
"Brain"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39734182",
"Title": "Journal of orthopaedic surgery and research",
"ArticleTitle": "A novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction.",
- "Abstract": "TPD surgery technique is a simple procedure that significantly increases the efficacy and reduces the complications of moderate diabetic foot ulcer patients, which could accelerate the formation of collateral circulation.",
+ "Abstract": "Researchers have proposed a novel surgical treatment for moderate diabetic foot ulcer: tibial periosteal distraction (TPD) which could improve affected limb microcirculation. We aimed to describe the method and therapeutic effects of this technique.We provided a technical guide to perform TPD surgery for the treatment of moderate diabetic foot ulcer of who had been treated in our department. The demographic information had been collected at the time of their admission. The patients were followed up at 3, 6, and 12 months after the operation with the ulcer area, skin temperature of the medial malleolus, transcutaneous oxygen pressure of the medial malleolus, ankle brachial index, dorsalis pedis artery pulsation, 12 item short form survey quality of life scale score, and visual analogue scale.A total of 35 patients with type 2 diabetes were included in this study, including 19 males and 16 females, with an average age of 62.49\u2009\u00b1\u200910.34 years and a maximum age of 87 years. The ulcers of all patients were cured, and the average healing time of ulcers was 8.09\u2009\u00b1\u20092.28 weeks, with no associated complications. The microcirculation indexes of the affected foot were significantly improved (p\u2009<\u20090.05). Three cases showed new vessels regeneration in the affected limbs according to their computed tomography angiography (CTA) results.TPD surgery technique is a simple procedure that significantly increases the efficacy and reduces the complications of moderate diabetic foot ulcer patients, which could accelerate the formation of collateral circulation.",
"Predictions": [
"Diabetes type 2"
],
@@ -571,32 +578,74 @@
"Wound Healing",
"Diabetes Mellitus, Type 2",
"Severity of Illness Index"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
- "PMID": "39733376",
- "Title": "Orvosi hetilap",
- "ArticleTitle": "[Analysis of laboratory tests in adults with diabetes in Hungary].",
- "Abstract": "",
+ "PMID": "39733807",
+ "Title": "Journal of the American Pharmacists Association : JAPhA",
+ "ArticleTitle": "Increasing SGLT-2 inhibitor prescribing through an integrated case-finding algorithm-guided interdisciplinary intervention.",
+ "Abstract": "Use of sodium-glucose cotransporter 2 inhibitors (SGLT-2 inhibitors) falls short of their cardiorenal protective benefits. Patient and provider-level barriers hinder the adoption of these life-saving medications. Innovative practices to provide primary care providers (PCPs) with added clinical-decision support via a dedicated remote interdisciplinary diabetes rounds (IDRs) team could promote SGLT-2 inhibitor selection.To evaluate the impact of the IDR's proactive provider outreach on the prescribing rate of SGLT-2 inhibitors and assess the application of an SGLT-2 inhibitor case-finding algorithm to allow targeted intervention in a population-health-based setting.This is a quality improvement prospective cohort observational study from October 2021 to May 2022. Patients who met the prespecified criteria for SGLT-2 eligibility were reviewed via IDR with recommendations sent to the PCP via the electronic health\u00a0record. The primary analysis employed a multivariate logistic regression to assess the difference in SGLT-2 inhibitor prescription rates between reviewed and not reviewed patients, adjusting for variables affecting SGLT-2 inhibitor prescribing. The secondary analysis measured the algorithm's accuracy in identifying patients with compelling indications.The IDR team reviewed a total of 206 patients (mean age, 63 years; 53.9% women; 42.7% Black; mean A1c 8.3%) with a successful PCP appointment. Patients reviewed by the IDR\u00a0team had an increased prescribing rate within 90 days of the visit (adjusted odds ratio 5.1, 95% CI 3.06-8.47). The algorithm identified 1084 SGLT-2 inhibitor-eligible patients with a sensitivity of 90.4% (95% CI, 86.4%, 94.4%) and specificity of 85.1% (95% CI, 79.9%, 90.4%).IDR team's review of eligible patients with recommendations to PCPs was associated with significantly increased SGLT-2 inhibitor prescription rates. Development of an algorithm with high sensitivity and specificity for targeted intervention may provide a pathway for channeling therapy and decreasing clinical inertia in population health management efforts.",
"Predictions": [
- "Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Hungary",
- "Male",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Algorithms",
"Female",
- "Retrospective Studies",
+ "Male",
"Middle Aged",
- "Adult",
- "Diabetes Mellitus",
- "Blood Glucose",
- "Glycated Hemoglobin",
+ "Prospective Studies",
"Aged",
- "Clinical Laboratory Techniques",
- "Diabetes Mellitus, Type 2"
- ]
+ "Diabetes Mellitus, Type 2",
+ "Practice Patterns, Physicians'",
+ "Quality Improvement",
+ "Primary Health Care",
+ "Cohort Studies",
+ "Electronic Health Records",
+ "Patient Care Team",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "39733524",
+ "Title": "Talanta",
+ "ArticleTitle": "Construction of a mitochondrial-targeting near-infrared fluorescent probe for detection of viscosity changes in type 2 diabetes mellitus and nonalcoholic steatohepatitis.",
+ "Abstract": "The intracellular viscosity plays a pivotal role as a physicochemical factor and an important indicator of organelles performance. Abnormal changes in subcellular viscosity are often associated with cellular malfunction and various diseases. Nonalcoholic steatohepatitis (NASH) is the most common liver disease related with type 2 diabetes mellitus (T2DM), and both are linked to aberrant mitochondrial viscosity. In this study, we styled and screened a novel near-infrared probe termed MT-E, carrying the double bonds as the viscosity response groups, that was employed to image the viscosity changes in HepG2 cells, zebrafish and animal models. MT-E has a superior mitochondrial targeting ability, as well as a large Stokes shift (167\u00a0nm). Additionally, utilizing the excellent performance of MT-E, we first monitored the increased viscosity trends in both T2DM mice and NASH mice, suggesting that there is a strong correlation between T2DM and NASH. More groundbreakingly, we have successfully revealed, from fluorescence imaging, the extraordinary potential of Aloin in treating T2DM mice that can effectively reduce viscosity. This is a sign that MT-E may have a steering role in mitochondrial viscosity-associated disorders.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Non-alcoholic Fatty Liver Disease",
+ "Animals",
+ "Diabetes Mellitus, Type 2",
+ "Fluorescent Dyes",
+ "Viscosity",
+ "Humans",
+ "Hep G2 Cells",
+ "Mice",
+ "Mitochondria",
+ "Zebrafish",
+ "Optical Imaging",
+ "Male",
+ "Mice, Inbred C57BL",
+ "Diabetes Mellitus, Experimental"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39733138",
@@ -621,27 +670,12 @@
"Gene Expression Profiling",
"Biomarkers",
"Cell Adhesion Molecules"
- ]
- },
- {
- "PMID": "39733115",
- "Title": "Scientific reports",
- "ArticleTitle": "Dynamic modeling of the Insulin-Glucose-Glucocorticoid impulsive control system.",
- "Abstract": "This paper introduces a class of insulin-glucose-glucocorticoid impulsive systems in the treatment of patients with diabetes to consider the effect of glucocorticoids. The existence and uniqueness of the positive periodic solution of the impulsive model at double fixed time is confirmed for type 1 diabetes mellitus (T1DM) using the [Formula: see text] function. Further, the global asymptotic stability of the positive periodic solution is achieved following Floquet multiplier theory and comparison principle. Additionally, the permanence of the system is confirmed in type 2 diabetes mellitus (T2DM) via the comparison theorem. Numerical analysis verifies the results of theoretical calculations and indicates that combining therapeutic strategies under hormonal interactions with the dose of exogenous insulin and glucocorticoid medicines within organisms provides more reasonable clinical strategies.",
- "Predictions": [
- "Diabetes type 1",
- "Diabetes type 2"
],
- "MeshTerms": [
- "Humans",
- "Insulin",
- "Glucocorticoids",
- "Diabetes Mellitus, Type 2",
- "Diabetes Mellitus, Type 1",
- "Glucose",
- "Blood Glucose",
- "Models, Biological"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39733102",
@@ -663,649 +697,653 @@
"Aged",
"ROC Curve",
"Non-alcoholic Fatty Liver Disease"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39732300",
- "Title": "Journal of ethnopharmacology",
- "ArticleTitle": "Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.",
- "Abstract": "Our findings demonstrated that GQD ameliorated liver injury in T2DM by inhibiting ferroptosis through the modulation of Nrf2.",
+ "PMID": "39732516",
+ "Title": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
+ "ArticleTitle": "Brain phosphoproteomic analysis identifies diabetes-related substrates in Alzheimer's disease pathology in older adults.",
+ "Abstract": "Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD-related phosphoprotein in the human brain remains underexplored.We performed tandem mass tag-based phosphoproteome profiling in post mortem human brain prefrontal cortex samples from 191 deceased older adults with and without diabetes and pathologic AD.Among 7874 quantified phosphosites, microtubule-associated protein tau (MAPT) phosphorylated at T529 and T534 (isoform 8 T212 and T217) were more abundant in AD and showed differential associations with diabetes. Network analysis of co-abundance patterns uncovered synergistic interactions between AD and diabetes, with one module exhibiting higher MAPT phosphorylation (15 MAPT phosphosites) and another displaying lower MAP1B phosphorylation (22 MAP1B phosphosites).This study offers phosphoproteomics insights into AD in diabetes, shedding light on mechanisms that can inform the development of therapeutics for dementia.The risk of Alzheimer's disease (AD) dementia is increased among older adults living with diabetes. The patterns of AD-related phosphoprotein in the human brain in older adults are differential among older adults living with diabetes. Microtubule-associated protein tau phosphorylated at T529 and T534 (isoform 8 T212 and T217) showed differential associations with diabetes. Phosphosite co-abundance networks of synergistic interactions between AD and diabetes were identified.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Ferroptosis",
- "NF-E2-Related Factor 2",
- "Diabetes Mellitus, Type 2",
+ "Humans",
+ "Alzheimer Disease",
"Male",
- "Drugs, Chinese Herbal",
- "Mice",
- "Diabetes Mellitus, Experimental",
- "Mice, Inbred C57BL",
- "Oxidative Stress",
- "Liver",
- "Diet, High-Fat",
- "Lipid Peroxidation",
- "Berberine",
- "Cell Line",
- "Glucosides",
- "Flavanones",
- "Streptozocin",
- "Isoflavones",
- "Flavonoids"
- ]
+ "Female",
+ "tau Proteins",
+ "Aged",
+ "Diabetes Mellitus, Type 2",
+ "Proteomics",
+ "Phosphoproteins",
+ "Aged, 80 and over",
+ "Phosphorylation",
+ "Brain",
+ "Prefrontal Cortex"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
- "PMID": "39731787",
- "Title": "European journal of medicinal chemistry",
- "ArticleTitle": "Corosolic acid and its derivatives targeting MCCC1 against insulin resistance and their hypoglycemic effect on type 2 diabetic mice.",
- "Abstract": "Corosolic acid (CA), a natural triterpenoid, exhibits various biological activities and is often called as plant-derived insulin due to its significant hypoglycemic effects, making it especially beneficial for individuals with diabetes or high blood glucose levels. However, CA has notable in vitro toxicity, low water solubility, and poor pharmacokinetic properties. To address these limitations, a series of CA derivatives were synthesized, resulting in the identification of derivative H26, which demonstrates a significantly enhanced hypoglycemic effect, reduced toxicity, and improved pharmacokinetic characteristics compared to CA. To identify the target protein of CA and investigate its therapeutic potential, a chemical probe derived from natural products, called CA-biotin, was designed and synthesized. By employing an avidin-biotin affinity binding system, we distinguished the differential protein bands between CA-biotin and biotin. This quantitative proteomic analysis revealed, for the first time, that the biotin-containing enzyme methylcrotonoyl-CoA carboxylase 1 (MCCC1) directly binds to CA. The interaction between H26 and MCCC1 was examined in vitro. The research on the mechanisms by which CA and H26 address Type 2 diabetes mellitus (T2DM) focused on the insulin resistance signaling pathway, specifically targeting MCCC1. The results indicated that H26 shows significant promise as a potential hypoglycemic agent, while MCCC1 may serve as a valuable target for addressing insulin resistance. This presents a promising opportunity for developing new medications aimed at improving the health of patients with type 2 diabetes mellitus (T2DM) or hyperglycemia.",
+ "PMID": "39697157",
+ "Title": "Praxis",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Insulin Resistance",
- "Animals",
- "Hypoglycemic Agents",
+ "Humans",
+ "Metformin",
+ "Glycated Hemoglobin",
+ "Sodium-Glucose Transporter 2 Inhibitors",
"Diabetes Mellitus, Type 2",
- "Mice",
- "Triterpenes",
+ "Hypoglycemic Agents",
"Male",
- "Diabetes Mellitus, Experimental",
- "Molecular Structure",
- "Structure-Activity Relationship",
- "Humans",
- "Dose-Response Relationship, Drug",
- "Mice, Inbred C57BL"
- ]
+ "Female",
+ "Body Weight",
+ "Middle Aged",
+ "Weight Loss"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39731761",
- "Title": "Terapevticheskii arkhiv",
- "ArticleTitle": "[Coagulase-negative staphylococci as a significant fact of generalization of infection in persons with a burdened comorbid background].",
- "Abstract": "Since the era of the widespread introduction of antibiotics into the human sphere of activity, the problem of antimicrobial resistance has become an urgent and very important topic around the world. Recently, coagulasonegative staphylococci (CoNS), which are representatives of opportunistic microorganisms of the microbiome of the skin and mucous membranes of healthy people, have made a certain contribution to its progression. For a long time, they did not pose a threat to patients, but in recent decades among microorganisms they have been seeded in more than two-thirds of patients with postoperative mediastinitis, catheter-associated infections, as well as from wounds of the neck vessels and the inguinal region separated by pacemaker beds. This paper discloses, using clinical examples, the significance of CoNS in the formation of systemic inflammatory response syndrome in patients with a burdened comorbid background (type II diabetes mellitus, grade 3 arterial hypertension). During the examination of patients, it was shown that skin defects are foci of persistent bacteremia of representatives of the CoNS group, which can cause the development of a systemic inflammatory infectious response with the formation of resistant strains of the opportunistic flora of the microbiome of the skin and mucous membranes. It has been shown that to determine the tactics of antibacterial therapy, a bacteriological study of all detected foci of infection in patients, screening of pathogens and their sensitivity to antibiotics, and especially in persons at risk, is necessary. This will increase the effectiveness of antibacterial therapy and reduce the possibility of forming resistant strains of pathogens.",
+ "PMID": "39693446",
+ "Title": "Science advances",
+ "ArticleTitle": "Meeting metformin again for the first time.",
+ "Abstract": "New evidence convincingly shows that metformin, a drug that reduces circulating glucose, acts by inhibiting mitochondrial complex I.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Animals",
"Humans",
- "Anti-Bacterial Agents",
- "Coagulase",
- "Comorbidity",
"Diabetes Mellitus, Type 2",
- "Staphylococcal Infections",
- "Staphylococcus",
- "Systemic Inflammatory Response Syndrome"
- ]
+ "Electron Transport Complex I",
+ "Hypoglycemic Agents",
+ "Metformin",
+ "Mitochondria"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39730990",
- "Title": "BMC primary care",
- "ArticleTitle": "The impact of the covid-19 pandemic on perceived diabetes care and regulation, with a focus on ethnic minorities: a mixed-methods study.",
- "Abstract": "In the context of proactive care, remote healthcare and self-regulation have a crucial role for people with T2DM. It is important to identify barriers and facilitators for maintaining good glycaemic control among vulnerable groups, such as ethnic minority groups.",
+ "PMID": "39667342",
+ "Title": "Cell host & microbe",
+ "ArticleTitle": "Guilds as guides for health vs. disease.",
+ "Abstract": "In a recent Cell paper, Wu et\u00a0al. identified microbiome guilds based on bacterial co-occurrence among type 2 diabetes patients. Two competing guilds, associated with high-fiber vs. control diets, correlated with healthy biomarkers. The potential of this approach was further verified across 15 diseases in 26 studies.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Adult",
- "Aged",
- "Female",
"Humans",
- "Male",
- "Middle Aged",
- "COVID-19",
"Diabetes Mellitus, Type 2",
- "Ethnic and Racial Minorities",
- "Primary Health Care",
- "Prospective Studies",
- "Telemedicine"
- ]
+ "Gastrointestinal Microbiome",
+ "Bacteria",
+ "Microbiota",
+ "Dietary Fiber",
+ "Diet",
+ "Biomarkers"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
},
{
- "PMID": "39730877",
- "Title": "Scientific reports",
- "ArticleTitle": "Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease.",
- "Abstract": "This study evaluated the ability of the triglyceride (TG) to high-density lipoprotein cholesterol (TG/HDL-C) ratio to identify individuals at risk of type 2 diabetes mellitus (T2DM) in the non-alcoholic fatty liver disease (NAFLD) population. We retrospectively studied 4,769 patients with NAFLD from the Affiliated Hospital of Hangzhou Normal University (2020-2023). Binary logistic regression models were used to evaluate the association between the TG/HDL-C ratio and lipid parameters with T2DM. TG/HDL-C ratio was positively associated with T2DM in patients with NAFLD, with an odds ratio (OR) of 2.72 (95% confidence interval, 2.23-3.31, p\u2009<\u20090.001) for T2DM in the highest TG/HDL-C ratio quartile compared with the lowest one after adjusting for known confounders. The OR for the TG/HDL-C ratio had a stronger predictive value than those of TG, total cholesterol, HDL-C, and low-density lipoprotein cholesterol, indicating that the TG/HDL-C ratio could be a better discriminator of T2DM. The TG/HDL-C ratio better identifies potential risks of T2DM in individuals with NAFLD than individual lipid parameters. Therefore, clinicians should pay attention to individuals with high TG and low HDL-C levels during T2DM risk assessment in NAFLD cohorts.",
+ "PMID": "39656379",
+ "Title": "Journal of cellular and molecular medicine",
+ "ArticleTitle": "Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic \u03b2 cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia-induced oxidative stress and endoplasmic reticulum (ER) stress enhances inflammatory disorders, leading to further pancreatic \u03b2 cell dysfunction. These changes trigger autophagy activation, which recycles cytoplasmic components and injured organelles. Autophagy regulates pancreatic \u03b2 cell functions by different mechanisms. Though the exact role of autophagy in T2DM is not completely elucidated, that could be beneficial or detrimental. Therefore, this review aims to discuss the exact role of autophagy in the pathogenesis of T2DM.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Humans",
"Diabetes Mellitus, Type 2",
- "Non-alcoholic Fatty Liver Disease",
- "Triglycerides",
- "Middle Aged",
- "Male",
- "Female",
- "Cholesterol, HDL",
- "Retrospective Studies",
- "Adult",
- "Risk Factors",
- "Aged"
- ]
+ "Autophagy",
+ "Humans",
+ "Animals",
+ "Insulin-Secreting Cells",
+ "Insulin Resistance",
+ "Endoplasmic Reticulum Stress",
+ "Oxidative Stress",
+ "Hyperglycemia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
},
{
- "PMID": "39730670",
- "Title": "Scientific reports",
- "ArticleTitle": "Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients.",
- "Abstract": "The correlation between thyroid hormone (TH) sensitivity and microvascular complications of type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to explore the association between TH sensitivity and the risk of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DNP) in euthyroid T2DM patients. This study included a total of 946 hospitalized T2DM patients and calculated their sensitivity to the TH index, and each patient completed screenings for DKD, DR, and DNP. Multivariate logistic regression, generalized additive modeling, and subgroup analysis were used to assess the association between TH index sensitivity and the risks of DKD, DR, and DNP. After adjusting for confounding factors, a significant linear correlation was observed between the sensitivity of the thyroid feedback quartile index 3 (TFQI3) and DKD risk. However, the sensitivities of thyroid-stimulating hormone index (TSHI), thyrotropin thyroxine resistance index (TT4RI) and partial thyroid feedback quartile index (PTFQI) exhibited nonlinear correlations with the risk of developing DKD. The effect sizes to the left of the inflection point for TSHI, TT4RI and PTFQI were (odd ratio [OR]\u2009=\u20090.53, 95% confidence interval [CI]: 0.288-0.977), (OR\u2009=\u20090.863, 95%Cl: 0.751-0.992) and (OR\u2009=\u20090.007, 95%Cl: 0-0.724), respectively. However, there was no significant correlation between TH index sensitivity and DR/DNP risk. This study provides valuable insights into the relationship between TH sensitivity and the risks of DKD, DR, and DNP, with substantial clinical implications for individual prediction among T2DM patients.",
+ "PMID": "39656373",
+ "Title": "Obesity surgery",
+ "ArticleTitle": "The Impact of Metabolic and Bariatric Surgery on Diabetic Kidney Disease in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis.",
+ "Abstract": "We aimed to determine the effect of metabolic and bariatric surgery (MBS) on the improvement of diabetic nephropathy (DN) in patients with obesity and type 2 diabetes (T2DM). A systematic search was performed in the PubMed, Embase, Scopus, and Web of Science databases. Meta-analysis of 31 studies with 2594 patients showed that urine albumin-to-creatinine ratio (UACR) was significantly reduced with a mean difference of\u2009-\u200928.19 mg/g (95% CI\u2009-\u200941.17,\u2009-\u200915.21, P-value\u2009<\u20090.001). In addition, subgroup analysis of studies showed a significant decrease after Roux-en-Y gastric bypass (RYGB) but not after sleeve gastrectomy (SG). These results suggest that MBS may lead to better kidney function and improvement in DN.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Male",
+ "Diabetic Nephropathies",
+ "Bariatric Surgery",
+ "Obesity, Morbid",
+ "Treatment Outcome",
+ "Gastric Bypass",
"Female",
+ "Male",
"Middle Aged",
- "Thyroid Hormones",
- "Aged",
- "Diabetic Nephropathies",
- "Diabetic Retinopathy",
- "Diabetic Neuropathies",
- "Thyrotropin",
- "Thyroid Gland",
- "Risk Factors",
- "Thyroxine"
- ]
+ "Gastrectomy",
+ "Adult",
+ "Albuminuria",
+ "Creatinine"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
},
{
- "PMID": "39730430",
- "Title": "Scientific reports",
- "ArticleTitle": "Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.",
- "Abstract": "Type 2 diabetes mellitus (T2DM) is associated with cellular abnormalities, tissue and organ dysfunctions, and periodontitis. This investigation examined the relationship between the oral microbiome and salivary biomarkers in T2DM patients with or without periodontitis. This cohort (35-80\u00a0years) included systemically healthy non-periodontitis (NP; n\u2009=\u200931), T2DM without periodontitis (DWoP; n\u2009=\u200932) and T2DM with periodontitis (DWP; n\u2009=\u200929). The oral microbiome [Operational Taxonomic Units (OTUs)] (16\u00a0s rRNA sequencing) and targeted host salivary biomarkers (immunoassays) were assessed. We identified 47 OTUs that were significantly different in abundance between NP samples and any disease subset or between disease subgroups. The most unique microbiome patterns were observed in the DWP group. Differences in genera/species abundance were also observed when T2DM patients were stratified by extent of periodontal inflammation and disease (i.e., generalized versus localized gingivitis/periodontitis). Salivary biomarkers showed significant elevations in MMP-8, MMP-9, resistin, IL-1\u03b2, IL-6, IFN\u03b1, and BAFF (THFSR13b) comparing generalized to localized periodontitis. Salivary analytes showed significant positive correlations with specific microbiome members, predominantly in DWP patients. Odds ratio analyses reinforced that a panel of biologic markers (IL-6, MMP-8) and bacteria (e.g., Bacteroidetes, Fusobacteria, Spirochaetes) discriminated the severity and extent of periodontal disease in this diabetic population.",
+ "PMID": "39647240",
+ "Title": "Clinical nutrition (Edinburgh, Scotland)",
+ "ArticleTitle": "Beyond fat: Does semaglutide affect lean mass?",
+ "Abstract": "This opinion paper aims to discuss the influence of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on lean mass beyond its impact on weight loss. Although significant weight loss is achieved with semaglutide, the impact of this drug on lean mass remains controversial. Several investigations have demonstrated that semaglutide-induced weight loss is linked to decreases in lean mass as well as fat mass; on the other hand, the ratio of lean mass to total body mass rises. Nevertheless, larger clinical trials have reported converse findings and significant reductions in lean mass following treatment with semaglutide. This disparity in research findings emphasizes the necessity for additional studies on this subject because semaglutide use is rising quickly.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Glucagon-Like Peptides",
"Humans",
+ "Weight Loss",
+ "Hypoglycemic Agents",
+ "Body Composition",
+ "Adipose Tissue",
"Diabetes Mellitus, Type 2",
- "Middle Aged",
- "Periodontitis",
- "Male",
- "Female",
- "Aged",
- "Saliva",
- "Biomarkers",
- "Gingivitis",
- "Adult",
- "Microbiota",
- "Aged, 80 and over",
- "RNA, Ribosomal, 16S"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39730335",
- "Title": "Scientific reports",
- "ArticleTitle": "Discontinuation rates, clinical effects and provocation factors of SGLT-2 inhibitor in the real world.",
- "Abstract": "Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are the only medications that improve clinical outcomes regardless of baseline left ventricular ejection fraction. Despite the recognized effectiveness of SGLT-2 inhibitors, there remains a paucity of research on the discontinuation of these medications. The objective of this study is to analyze the rate of discontinuation of SGLT-2 inhibitors, to evaluate the impact of discontinuation on the clinical outcome, and to identify the factors associated with discontinuation. From 2015 to 2021, 775 heart failure patients prescribed an SGLT-2 inhibitor were retrospectively collated at Samsung Medical Center, Seoul, Republic of Korea. The SGLT-2 inhibitor discontinuation rate and the effect of SGLT-2 inhibitor discontinuation on clinical outcome were analyzed using the Kaplan-Meier survival curve. Factors related to discontinuation were analyzed through Cox regression and competing risk survival analysis. The discontinuation rate of SGLT-2 inhibitors was 7.5% at 1\u00a0year and 20% at 5\u00a0years. General weakness, over-diuresis and volume depletion, renal dysfunction progression, and urinary tract infections are the major reasons for discontinuing SGLT-2 inhibitors in general medical practice. The group that stopped using SGLT-2 inhibitors had a higher rate of heart failure hospitalization than the control group (adjusted HR 2.600, 95% CI [1.233-5.481], P\u2009=\u20090.012). In multivariable Cox regression analysis, the factors associated with total SGLT-2 inhibitor discontinuation were women (HR 2.478, 95% CI [1.553-3.953], P\u2009<\u20090.001) and lower estimated glomerular filtration rate (eGFR) (HR 0.884 per 10\u00a0ml/min/1.73\u00a0m",
+ "PMID": "39639620",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[SGLT2 inhibitors : promises, but for whom ?].",
+ "Abstract": "In type 2 diabetes, the launch of gliflozins (or SGLT2i), like each new therapeutic class, is generating a great deal of hope and is being heavily marketed. The pivotal studies show a beneficial effect on the risk of hospitalization for heart failure and, to a lesser extent, on the decline in renal function. The impact on physiological factors (weight, glycated hemoglobin, blood pressure) is modest, and the side-effect profile is relatively heavy, particularly in the elderly (frequent urogenital infections, ketoacidosis, etc.). The aim of this article is first and foremost to take a critical look at the interpretation of clinical studies and to identify populations where a favorable benefit/risk balance cannot be guaranteed.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Sodium-Glucose Transporter 2 Inhibitors",
- "Female",
- "Male",
- "Heart Failure",
- "Middle Aged",
- "Aged",
- "Retrospective Studies",
"Diabetes Mellitus, Type 2",
- "Republic of Korea"
- ]
- },
+ "Hypoglycemic Agents",
+ "Heart Failure"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "6"
+ }
+ },
{
- "PMID": "39730078",
- "Title": "Contemporary clinical trials",
- "ArticleTitle": "The sleep for health study: A randomized clinical trial of the impact of insomnia treatment on glycemia in people with prediabetes.",
- "Abstract": "This trial is testing whether a program to improve sleep will positively impact glycemia among those with prediabetes. Registration with clinicaltrials.gov on October 3, 2023: NCT06067139.",
+ "PMID": "39622719",
+ "Title": "Zhonghua nei ke za zhi",
+ "ArticleTitle": "[Glucokinase activators: the first step in regulating intracellular glucose metabolism].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Sleep Initiation and Maintenance Disorders",
- "Prediabetic State",
- "Glycated Hemoglobin",
- "Cognitive Behavioral Therapy",
- "Blood Glucose",
- "Male",
- "Female",
- "Insulin Resistance",
- "Middle Aged",
+ "Glucokinase",
"Diabetes Mellitus, Type 2",
- "Blood Glucose Self-Monitoring",
- "Adult",
- "Patient Education as Topic",
- "Aged",
- "Sleep"
- ]
+ "Glucose",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39729922",
- "Title": "International immunopharmacology",
- "ArticleTitle": "Eldecalcitol alleviates diabetic periodontitis by regulating macrophage efferocytosis and polarization via SOCE machinery.",
- "Abstract": "Diabetes exacerbates the occurrence and severity of periodontitis, the pathogenesis of diabetic periodontitis (DPD) is influenced by the delayed resolution of inflammation. Eldecalcitol (ED-71) has shown promise in preventing bone loss in DPD. We herein aimed to investigate the role of ED-71 in the inflammatory regression phase of DPD and elucidate the underlying mechanisms. Type-2 diabetes was induced by streptozotocin injection in Wistar rats, and to explore the in vivo effect of ED-71 on macrophage efferocytosis, periodontitis was induced by ligation combined with lipopolysaccharide. Alveolar bone destruction was assessed using micro-computed tomography, hematoxylin-eosin, immunohistochemistry, and tartrate-resistant acid phosphatase staining. Immunofluorescence staining and flow cytometry detected neutrophils, apoptotic cells, and macrophage polarization in periodontal tissue. Additionally, flow cytometry, real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay were used to examine macrophage efferocytosis and changes in store-operated calcium entry (SOCE). We found that rats with diabetes exhibited more severe alveolar bone destruction and increased neutrophil aggregates in periodontal tissue. Following the ED-71 administration, alveolar bone loss significantly decreased, and the immune microenvironment of periodontal tissue tended to suppress inflammation. Macrophages stimulated with high glucose experienced disruption of SOCE machinery, leading to the inhibition of efferocytosis in vitro. ED-71 demonstrated the ability to restore macrophage efferocytosis by correcting SOCE, and preventing sustained inflammatory damage to periodontal tissue. In conclusion, diabetes impairs macrophage efferocytosis and M2 polarization in periodontitis rats, resulting in the delayed resolution of inflammation. ED-71 could attenuate alveolar bone loss by mitigating macrophage via SOCE machinery in DPD.",
+ "PMID": "39622714",
+ "Title": "Zhonghua nei ke za zhi",
+ "ArticleTitle": "[Progress of type 2 diabetes in the past decade].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Periodontitis",
- "Male",
- "Rats, Wistar",
- "Macrophages",
- "Diabetes Mellitus, Experimental",
- "Rats",
- "Alveolar Bone Loss",
- "Vitamin D",
- "Phagocytosis",
"Diabetes Mellitus, Type 2",
- "Calcium",
- "Efferocytosis"
- ]
+ "Humans",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39729784",
- "Title": "Cancer epidemiology",
- "ArticleTitle": "The impact of type 2 diabetes on melanoma stage (TNM) at the time of diagnosis and its association with sex: A Danish nationwide study.",
- "Abstract": "Individuals with T2D were more likely to be diagnosed with advanced stages of local, regional, and distant melanoma. This highlights the need for greater melanoma awareness and further research into treatment responses in individuals with T2D.",
+ "PMID": "39622320",
+ "Title": "No shinkei geka. Neurological surgery",
+ "ArticleTitle": "[Pharmacological Treatment for Type 2 Diabetes].",
+ "Abstract": "Diabetes management primarily aims to achieve a life expectancy and quality of life similar to that of people without diabetes. The key to achieving this goal is the effective prevention and management of both the microvascular and macrovascular complications associated with diabetes. Although glycated hemoglobin levels of less than 7% are recommended to minimize complications, individual targets should be set considering variables such as age, duration of diabetes, risk of hypoglycemia, organ function, support system, general health status, and social background. Treatment decisions should be individualized according to each patient's diabetes status and guided by the latest evidence on diabetes pharmacotherapy.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Melanoma",
- "Male",
- "Female",
"Diabetes Mellitus, Type 2",
- "Denmark",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Aged",
- "Neoplasm Staging",
- "Adult",
- "Sex Factors",
- "Skin Neoplasms",
- "Registries",
- "Lymphatic Metastasis",
- "Aged, 80 and over"
- ]
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39729310",
- "Title": "Genetic testing and molecular biomarkers",
- "ArticleTitle": "Evaluation of Soluble Tumor Necrosis Factor-Like Weak Inducer of Apoptosis, Omentin, and Tumor Necrosis Factor-\u03b1 in Subjects with Periodontitis and Type 2 Diabetes Mellitus.",
- "Abstract": {
- "b": [
- {
- "i": "Purpose:"
- },
- {
- "i": "Materials and Methods:"
- },
- {
- "i": "Results:"
- },
- {
- "i": "Conclusion:"
- }
- ]
- },
+ "PMID": "39622055",
+ "Title": "Annals of internal medicine",
+ "ArticleTitle": "After COVID-19 diagnosis, risk for incident type 2 diabetes was elevated for up to 2 y.",
+ "Abstract": "Taylor K, Eastwood S, Walker V, et al. Lancet Diabetes Endocrinol. 2024;12:558-568. 39054034.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Lectins",
+ "COVID-19",
+ "Incidence",
+ "SARS-CoV-2",
+ "Retrospective Studies",
"Male",
- "Female",
- "GPI-Linked Proteins",
+ "England",
"Middle Aged",
- "Periodontitis",
- "Cytokines",
- "Tumor Necrosis Factor-alpha",
+ "Female",
+ "Risk Factors",
"Adult",
- "Biomarkers",
- "Cytokine TWEAK",
- "Glycated Hemoglobin"
- ]
+ "COVID-19 Vaccines",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
- "PMID": "39729235",
- "Title": "Journal of molecular histology",
- "ArticleTitle": "Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities.",
- "Abstract": "It is crucial to investigate new anti-diabetic agents and therapeutic approaches targeting molecules in potential signaling pathways for the treatment of Type 2 diabetes mellitus (T2DM). The objective of the study was to investigate the total phenolic content, antioxidant capacity, \u03b1-glucosidase, and \u03b1-amylase inhibitory activities of Bolanthus turcicus (B. turcicus), as well as their cytotoxic, anti-adipogenic, anti-diabetic, apoptotic, and anti-migration potential on adipocytes. B. turcicus samples were extracted with methanol (MeOH), ethyl acetate (EA) and aqueous (Aq) solvents. The MeOH extract had the highest phenolic content (81.14\u00a0mg GAE/g), followed by EA (74.93\u00a0mg GAE/g) and Aq (51.09\u00a0mg GAE/g). All extracts exhibited dose-dependent increases in \u03b1-glycosidase and \u03b1-amylase inhibitory activity. B. turcicus extracts showed cytotoxic effect on adipocytes with IC",
+ "PMID": "39595541",
+ "Title": "Biomolecules",
+ "ArticleTitle": "Emerging Roles of ncRNAs in Type 2 Diabetes Mellitus: From Mechanisms to Drug Discovery.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM), a high-incidence chronic metabolic disorder, has emerged as a global health issue, where most patients need lifelong medication. Gaining insights into molecular mechanisms involved in T2DM development is expected to provide novel strategies for clinical prevention and treatment. Growing evidence validates that non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) function as crucial regulators in multiple biological processes of T2DM, inspiring various potential targets and drug candidates. In this review, we summarize the current understanding of ncRNA roles in T2DM and discuss the potential use of ncRNAs as targets and active molecules for drug discovery.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Antioxidants",
- "Plant Extracts",
+ "Diabetes Mellitus, Type 2",
+ "Humans",
+ "Drug Discovery",
+ "RNA, Untranslated",
+ "RNA, Circular",
+ "MicroRNAs",
"Animals",
- "Hypoglycemic Agents",
- "Adipogenesis",
- "Mice",
- "Adipocytes",
- "Apoptosis",
- "Asteraceae",
- "3T3-L1 Cells",
- "alpha-Amylases",
- "Cell Movement",
- "Phenols",
- "Diabetes Mellitus, Type 2"
- ]
+ "RNA, Long Noncoding"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "27"
+ }
},
{
- "PMID": "39728692",
- "Title": "Investigative ophthalmology & visual science",
- "ArticleTitle": "Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy.",
- "Abstract": "Retinal DHA is reduced in diabetic humans and mice, which is associated with a thinning of retina and functional defects in diabetic mice. Enriching retinal DHA through diet may be beneficial in the prevention and treatment of diabetic retinopathy.",
+ "PMID": "39585292",
+ "Title": "Journal of Ayub Medical College, Abbottabad : JAMC",
+ "ArticleTitle": "SCLEREDEMA DIABETICORUM; A RARE DISEASE.",
+ "Abstract": "Scleredema Diabeticorum (SD) is a rare condition characterized by diffuse, symmetrical induration along with non-pitted swelling mostly on the upper back as a result of mucin being deposited in the dermis. It can also involve posterior neck, shoulders, and scalp. We report a case of 48 years old female patient from Pakistan, with uncontrolled diabetes mellites type 2 for the last 15 years, presenting with thickened skin at the back of the neck resulting in difficulty in neck and shoulder movements. This led to decreased functional class from I to II causing her to develop insomnia and depression. Scleredema diabeticorum is a difficult disease to manage as it runs a long and debilitating course with little propensity of remission with available treatments.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Docosahexaenoic Acids",
- "Animals",
- "Diabetic Retinopathy",
- "Mice",
"Humans",
- "Electroretinography",
- "Retina",
- "Tomography, Optical Coherence",
- "Male",
- "Middle Aged",
- "Mice, Inbred C57BL",
"Female",
- "Diabetes Mellitus, Experimental",
- "Gas Chromatography-Mass Spectrometry",
- "Real-Time Polymerase Chain Reaction",
+ "Middle Aged",
+ "Scleredema Adultorum",
"Diabetes Mellitus, Type 2",
- "Aged",
- "Adult"
- ]
+ "Rare Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "25"
+ }
},
{
- "PMID": "39726656",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Associations of adolescent obesity with hypertension, diabetes mellitus and polycystic ovaries in Arabs and Jews in Israel-a nationwide study.",
- "Abstract": "The finding of a strong association of obesity severity with major cardiometabolic consequences in adolescence, as well as the unique ethnic features of these associations, can help focus national health initiatives on vulnerable adolescent groups.",
+ "PMID": "39571131",
+ "Title": "American journal of public health",
+ "ArticleTitle": "Evaluation of a Chronic Care Management Model for Improving Efficiency and Fiscal Sustainability.",
+ "Abstract": "Chronic care management is effective. Barriers to program durability include dependence on the provider-nurse duo to carry out labor-intensive services and the lack of a fiscally sustainable model. Between January and October 2022, an expanded chronic care management team-consisting of a provider, nurse, community health worker, and pharmacist-conducted a four-month intervention in an ambulatory setting. This intervention, using a convenience sample of 134 Medicare patients with uncontrolled type 2 diabetes or hypertension, demonstrated statistically significant improvements in controlling type 2 diabetes (\u2009<\u2009.01) and blood pressure (\u2009<\u2009.001). Direct provider workload decreased, and the Medicare reimbursement rate was 85.5%. (. 2025;115(2):133-137. https://doi.org/10.2105/AJPH.2024.307886).",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Israel",
- "Female",
- "Adolescent",
- "Arabs",
- "Cross-Sectional Studies",
- "Jews",
- "Polycystic Ovary Syndrome",
- "Hypertension",
- "Young Adult",
+ "United States",
+ "Medicare",
"Diabetes Mellitus, Type 2",
- "Pediatric Obesity",
- "Prevalence",
+ "Hypertension",
+ "Chronic Disease",
+ "Aged",
"Male",
- "Comorbidity"
- ]
+ "Female",
+ "Program Evaluation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "21"
+ }
},
{
- "PMID": "39725431",
- "Title": "BMJ open",
- "ArticleTitle": "Pre-diabetes virtual health management community (VHMC) intervention and group interaction management model in China: a randomised clinical trial protocol.",
- "Abstract": "ChiCTR2400081268. Study start: 1 July 2024, completion: 1 December 2026.",
+ "PMID": "39561499",
+ "Title": "European journal of medicinal chemistry",
+ "ArticleTitle": "Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives.",
+ "Abstract": "Development of allosteric inhibitors may be a viable strategy to discover hypoglycemic drugs targeting PTP1B. Allosteric inhibitors occupying the BB site that is a hydrophobic pocket restrict the WPD loop in an open conformation, preventing the physiological dephosphorylation reaction. Toward the BB site, sixty bromocatechol-chalcone derivatives were designed and synthesized as allosteric inhibitors of PTP1B against diabetes mellitus. The most potent compound LXQ-87 (C8) inhibited PTP1B noncompetitively with an IC value of 1.061\u00a0\u00b1\u00a00.202\u00a0\u03bcM. Oral administration of LXQ-87 reduces the fasting blood glucose level and improves glucose tolerance and dyslipidemia in BKS db/db mice suffering from T2DM. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake by directly binding to intracellular PTP1B.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Protein Tyrosine Phosphatase, Non-Receptor Type 1",
+ "Animals",
+ "Mice",
+ "Allosteric Regulation",
"Humans",
- "Prediabetic State",
- "China",
- "Diabetes Mellitus, Type 2",
- "Randomized Controlled Trials as Topic",
- "Prospective Studies",
- "Single-Blind Method",
- "Telemedicine",
- "Multicenter Studies as Topic",
- "Cost-Benefit Analysis",
+ "Structure-Activity Relationship",
+ "Catechols",
+ "Molecular Structure",
+ "Enzyme Inhibitors",
+ "Hypoglycemic Agents",
+ "Dose-Response Relationship, Drug",
+ "Chalcones",
+ "Chalcone",
"Male",
- "Group Dynamics"
- ]
+ "Diabetes Mellitus, Type 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "20"
+ }
},
{
- "PMID": "39725366",
- "Title": "Journal of ethnopharmacology",
- "ArticleTitle": "Study on the mechanism on Yi-guan-jian decoction alleviating cognitive dysfunction in type 2 diabetes mellitus.",
- "Abstract": "YGJ can alleviate glucose homeostasis, insulin sensitivity, lipid metabolism, neuroinflammation, cognitive function, as well as remodel intestinal flora and BA composition in CDT2DM rats, which is a potential complementary and alternative therapy for the prevention and treatment of CDT2DM. These effects may be associated that YGJ regulates the structure of intestinal flora and BA metabolism, and inhibits intestinal BA receptors FXR, PXR, TGR5, and VDR.",
+ "PMID": "39561332",
+ "Title": "Diabetes",
+ "ArticleTitle": "Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes.",
+ "Abstract": "It is unclear why some individuals with type 2 diabetes are unresponsive to treatment with glucagon-like peptide 1 receptor (GLP-1R) agonists, but hypothalamic-pituitary-adrenal (HPA) axis activation could play a role. We used [68Ga]Ga-NODAGA-exendin-4 positron emission tomography/computed tomography to compare pituitary GLP-1R expression between responders and nonresponders to treatment with GLP-1R agonists. Pituitary GLP-1R expression and HPA axis activation did not differ between responders and nonresponders to GLP-1R agonist treatment. In addition, pituitary radiolabeled exendin uptake was markedly higher in men than in women. Further study is required to explain treatment differences and understand sex differences in pituitary radiolabeled exendin uptake.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
+ "Humans",
"Diabetes Mellitus, Type 2",
- "Drugs, Chinese Herbal",
+ "Glucagon-Like Peptide-1 Receptor",
"Male",
- "Cognitive Dysfunction",
- "Rats",
- "Gastrointestinal Microbiome",
- "Diabetes Mellitus, Experimental",
- "Rats, Sprague-Dawley",
- "Bile Acids and Salts",
+ "Hypothalamo-Hypophyseal System",
+ "Female",
+ "Pituitary-Adrenal System",
+ "Exenatide",
+ "Middle Aged",
+ "Positron Emission Tomography Computed Tomography",
"Hypoglycemic Agents",
- "Insulin Resistance",
- "Hippocampus",
- "Maze Learning"
- ]
+ "Aged",
+ "Pituitary Gland"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "19"
+ }
},
{
- "PMID": "39724976",
- "Title": "Preventive medicine",
- "ArticleTitle": "Adherence to recommended blood-based screening tests for cancer and chronic diseases: A systematic literature review.",
- "Abstract": "Real-world adherence to recommended blood-based screening is suboptimal. Future research is needed to determine whether these findings are generalizable to blood-based CRC screening and to assess how such a strategy could impact clinical, economic, and health equity outcomes.",
+ "PMID": "39548626",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Physio-Friendly Remission-Facilitating Pharmacotherapy (PRP) in Type 2 Diabetes.",
+ "Abstract": "This brief communication describes the concept of physiofriendly pharmacotherapy for type 2 diabetes mellitus. Physio-friendly therapy is defined as that which restores metabolic, including glycaemic and weight homoeostasis, to near normal levels. Drugs such as glucagon like peptide 1 receptor agonists (GLP1RA), sodium glucose cotransporter- 2 inhibitors (SGLT2i), and alfa glucosidase inhibitors, along with metformin, work in a physio-friendly manner and may facilitate remission. Thus, they can also be termed as remission-facilitating drugs.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Early Detection of Cancer",
- "Colorectal Neoplasms",
- "Mass Screening",
- "Prostate-Specific Antigen",
- "Chronic Disease",
- "Male",
- "Guideline Adherence",
- "Prostatic Neoplasms",
"Diabetes Mellitus, Type 2",
- "HIV Infections",
- "Dyslipidemias"
- ]
+ "Hypoglycemic Agents",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Metformin",
+ "Remission Induction",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "16"
+ }
},
{
- "PMID": "39723533",
- "Title": "Annals of medicine",
- "ArticleTitle": "Exploring the effect and mechanism of action of Jinlida granules (JLD) in\u00a0the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.",
- "Abstract": "The findings suggested that JLD has the potential to improve TDACI through multiple components, multiple targets and multiple pathways. JLD may be a promising treatment for diabetic cognitive impairment.",
+ "PMID": "39506571",
+ "Title": "Clinical laboratory",
+ "ArticleTitle": "Pedigree Analysis of Maturity-Onset Diabetes of the Young: ABCC8 Mutations?",
+ "Abstract": "Maturity-Onset Diabetes of the Young (MODY) is an autosomal dominant disease, caused by muta-tions in the ABCC8 gene, chromosome 11.A case suspected of MODY due to an ABCC8 mutation was examined using whole-genome exon high-throughput sequencing. Selected variant sites were validated via Sanger sequencing.A heterozygous mutation c.2060C>T (p.T687M) in exon 15 of the ABCC8 gene (Chr11-174494701) was identified in both the proband and the father. This mutation was initially linked to MODY based on clinical fea\u00actures.For patients with high suspicion of MODY, genetic test should conducted to improve their quality of life.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Cognitive Dysfunction",
- "Mice",
- "Network Pharmacology",
- "Molecular Docking Simulation",
+ "Humans",
+ "Sulfonylurea Receptors",
"Diabetes Mellitus, Type 2",
- "Drugs, Chinese Herbal",
"Male",
- "Diabetes Mellitus, Experimental",
- "Protein Interaction Maps",
- "Hippocampus",
- "Signal Transduction",
- "Disease Models, Animal",
- "Morris Water Maze Test"
- ]
+ "Pedigree",
+ "Mutation",
+ "Adult",
+ "Genetic Predisposition to Disease",
+ "Female",
+ "DNA Mutational Analysis",
+ "Heterozygote",
+ "Exons"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "9"
+ }
},
{
- "PMID": "39722814",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Elevated circulating homocysteine concentrations delayed nerve conduction velocity and increase the risk of diabetic kidney disease in patients with type 2 diabetes.",
- "Abstract": "The clinical assessment of homocysteine in diabetic patients holds significant importance in the prevention of microvascular complications. Lowering HCY levels may offer a promising therapeutic approach for managing microvascular disease in diabetes.",
+ "PMID": "39478377",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Prescription of GLP-1 receptor agonists and iSGLT2 in geriatrics, is there a risk?].",
+ "Abstract": "The use of GLP-1 receptor agonists and iSGLT2 is becoming increasingly common, in line with new guidelines issued by the learned societies of cardiology, nephrology and diabetology. However, the enthusiasm aroused by these new drugs needs to be tempered and their use in the very elderly and/or frail needs to be carefully considered by the lack of scientific studies in this population category, , and their prescription requires a comprehensive geriatric assessment before initiating this type of treatment.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 2",
- "Homocysteine",
- "Male",
- "Female",
- "Middle Aged",
- "Neural Conduction",
- "Diabetic Nephropathies",
- "Diabetic Neuropathies",
"Aged",
- "Risk Factors",
- "China"
- ]
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Geriatric Assessment",
+ "Practice Guidelines as Topic",
+ "Geriatrics",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "31"
+ }
},
{
- "PMID": "39722811",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Unveiling risk factors for post-COVID-19 syndrome development in people with type 2 diabetes.",
- "Abstract": "Patients who were newly diagnosed with T2D, had HbA1c above 9.2%, had previous cardiovascular or cerebrovascular events, and had severe COVID-19 associated with mechanical lung ventilation were at high risk for PCS.",
+ "PMID": "39474830",
+ "Title": "Nederlands tijdschrift voor geneeskunde",
+ "ArticleTitle": "[Acute blindness in a patient with metformin-associated lactic acidosis].",
+ "Abstract": "Lactic acidosis is a rare metabolic complication that can occur in patients with diabetes mellitus type 2 who use metformin. We discuss a 79-year old woman with metformin-associated lactic acidosis (MALA) and acute kidney injury based on gastroenteritis. Patient reported acute blindness which in literature is described as a rare presentation of a metabolic acidosis (regardless of its underlying cause). Immediate treatment with hemodialysis led to improvement of the acidosis and complete recovery of the vision. It is important that patients who use metformin are instructed to consult their health care provider and/or discontinue metformin in case of intercurrent diseases.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetes Mellitus, Type 2",
- "COVID-19",
- "Female",
- "Male",
- "Middle Aged",
- "Risk Factors",
- "Post-Acute COVID-19 Syndrome",
+ "Metformin",
+ "Acidosis, Lactic",
"Aged",
- "Adult",
- "Ukraine",
- "SARS-CoV-2"
- ]
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Blindness",
+ "Hypoglycemic Agents",
+ "Renal Dialysis",
+ "Acute Kidney Injury",
+ "Acute Disease",
+ "Gastroenteritis",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "30"
+ }
},
{
- "PMID": "39721796",
- "Title": "Obesity (Silver Spring, Md.)",
- "ArticleTitle": "Racial disparities in gestational weight gain and adverse pregnancy outcomes among Black and White pregnant people with obesity.",
- "Abstract": "Black individuals\u00a0with obesity started pregnancy with higher weight and more preexisting conditions but had lower GWG compared to White individuals. Exacerbated disparities in preexisting conditions demonstrate higher health risks for Black individuals during pregnancy.",
+ "PMID": "39474653",
+ "Title": "AIDS (London, England)",
+ "ArticleTitle": "Hepatic steatosis-insulin resistance and type 2 diabetes in people with HIV at diagnosis: effect of initial antiretroviral therapy.",
+ "Abstract": "We evaluated the impact of hepatic steatosis-insulin resistance (HS-IR) and liver fibrosis (LF) on type 2 diabetes mellitus (DM2) using triglyceride-glucose (TyG) and Fibrosis-4 (FIB-4). The incidence of DM2 was 12.9 [95% confidence interval (CI), 16.9-9.7] and 9.8 (95% CI, 6.9-13.6) per 1000 person-years in HS-IR and LF. The prevalence of HS-IR was significantly lower at 12 and 24\u200amonths with TDF + (3TC or FTC) + RPV [hazard ratio (HR) 0.5 [95% CI, 0.3-0.8], P\u200a<\u200a0.01 at 12\u200amonths; 0.6 [0.4-0.9], P\u200a=\u200a0.01 at 24\u200amonths].",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Diabetes Mellitus, Type 2",
+ "Insulin Resistance",
+ "Male",
+ "HIV Infections",
"Female",
- "Pregnancy",
- "Gestational Weight Gain",
- "White People",
+ "Middle Aged",
"Adult",
- "Retrospective Studies",
- "Pregnancy Outcome",
- "Obesity",
- "COVID-19",
- "Pregnancy Complications",
- "Black or African American",
- "Health Status Disparities",
- "Louisiana",
- "Diabetes, Gestational",
- "Diabetes Mellitus, Type 2"
- ]
+ "Fatty Liver",
+ "Incidence",
+ "Anti-Retroviral Agents",
+ "Prevalence",
+ "Liver Cirrhosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "30"
+ }
},
{
- "PMID": "39720906",
- "Title": "European journal of endocrinology",
- "ArticleTitle": "Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model.",
- "Abstract": "Baseline HbA1c and 2-h OGTT glucose predict incident type 2 diabetes at 2 years in high-risk men, with risk modified independently by testosterone treatment. Men with HbA1c \u2265 5.6% (38\u2005mmol/mol) benefit most from testosterone treatment, beyond a lifestyle program.",
+ "PMID": "39471997",
+ "Title": "International journal of STD & AIDS",
+ "ArticleTitle": "Genital-oral transmission of .",
+ "Abstract": "is a vaginal commensal. Cases of vaginitis, vulvovaginitis and recurrent vulvovaginitis caused by this yeast are very rare. In the oral cavity, causes stomatitis in immunocompromised patients. We describe a case of stomatitis and angular cheilitis caused by in a female patient with type 2 diabetes. The infection was most likely transmitted following genital-oral intercourse with the patient's girlfriend, who was affected by vulvovaginitis.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Female",
+ "Candida",
+ "Candidiasis, Vulvovaginal",
"Diabetes Mellitus, Type 2",
- "Male",
- "Testosterone",
+ "Stomatitis",
+ "Antifungal Agents",
"Middle Aged",
- "Aged",
- "Australia",
- "Risk Factors",
- "Glucose Tolerance Test",
- "Glycated Hemoglobin",
- "Prognosis",
- "Blood Glucose",
- "Glucose Intolerance",
- "Life Style",
- "Risk Assessment"
- ]
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "30"
+ }
},
{
- "PMID": "39720308",
- "Title": "Journal of diabetes research",
- "ArticleTitle": "Young-Onset Diabetes in Sri Lanka: Experience From the Developing World.",
- "Abstract": {
- "b": "Conclusion:",
- "i": "p"
- },
+ "PMID": "39463020",
+ "Title": "Journal of diabetes",
+ "ArticleTitle": "Stratum corneum hydration levels are negatively correlated with HbA1c levels in the elderly Chinese.",
+ "Abstract": "Highlights Stratum corneum hydration levels are negatively correlated with HbA1c levels and positively correlated with skin surface pH. Individuals with type 2 diabetes display lower levels of stratum corneum hydration. Because low stratum corneum hydration levels can increase circulating levels of proinflammatory cytokines, which are linked to the pathogenesis of type 2 diabetes, improvement in stratum corneum hydration can be an alternative approach in the management of type 2 diabetes.",
"Predictions": [
- "Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
- "Humans",
- "Sri Lanka",
+ "Aged",
+ "Aged, 80 and over",
"Female",
+ "Humans",
"Male",
- "Diabetes Mellitus, Type 1",
- "Adolescent",
- "Young Adult",
+ "Middle Aged",
+ "China",
"Diabetes Mellitus, Type 2",
- "Age of Onset",
- "Retrospective Studies",
- "Prevalence",
- "Developing Countries",
- "Child",
- "Adult",
+ "East Asian People",
+ "Epidermis",
"Glycated Hemoglobin",
- "Diabetic Ketoacidosis"
- ]
+ "Hydrogen-Ion Concentration",
+ "Skin"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "28"
+ }
},
{
- "PMID": "39720253",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Sclerostin as a new target of diabetes-induced osteoporosis.",
- "Abstract": "Sclerostin, a protein synthesized by bone cells, is a product of the ",
+ "PMID": "39460581",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Incretin hormones: Revolutionizing the treatment landscape for kidney and liver diseases in type 2 diabetes and obesity.",
+ "Abstract": "Several ongoing trials are evaluating incretin-based therapies, including GLP-1 receptor agonists, for their effects on CKD and MASLD. These studies will offer insights into their potential for metabolic diseases in people with type 2 diabetes and obesity.",
"Predictions": [
- "Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Osteoporosis",
- "Adaptor Proteins, Signal Transducing",
- "Diabetes Mellitus, Type 1",
"Diabetes Mellitus, Type 2",
- "Animals",
- "Genetic Markers",
- "Wnt Signaling Pathway",
- "Bone Morphogenetic Proteins"
- ]
+ "Incretins",
+ "Obesity",
+ "Liver Diseases",
+ "Glucagon-Like Peptide-1 Receptor",
+ "Kidney Diseases",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "26"
+ }
},
{
- "PMID": "39720249",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Traditional versus intensive blood glucose control: long-term target range duration and cardiovascular disease risk and all-cause mortality - a real-world cohort study.",
- "Abstract": "In patients with type 2 diabetes, achieving near-normal blood glucose levels appears to significantly reduce the risk of diabetes-related cardiovascular outcomes.",
+ "PMID": "39455184",
+ "Title": "Sleep medicine clinics",
+ "ArticleTitle": "Sleep Deficiency and Cardiometabolic Disease.",
+ "Abstract": "Epidemiologic studies have demonstrated that short sleep duration is associated with an increased risk of cardio-metabolic health outcomes including cardiovascular disease mortality, coronary heart disease, type 2 diabetes mellitus, hypertension, and metabolic syndrome. Experimental sleep restriction studies have sought to explain these findings. This review describes the main evidence of these associations and possible mechanisms explaining them. Whether sleep extension reverses these now widely acknowledged adverse health effects and the feasibility of implementing such strategies on a public health level is discussed.",
"Predictions": [
"Cardiovascular diseases",
"Diabetes type 2"
@@ -1313,1150 +1351,1243 @@
"MeshTerms": [
"Humans",
"Cardiovascular Diseases",
- "Male",
- "Female",
+ "Metabolic Syndrome",
+ "Sleep Deprivation",
"Diabetes Mellitus, Type 2",
- "Middle Aged",
- "Blood Glucose",
- "Glycemic Control",
- "Cohort Studies",
- "Aged",
- "Follow-Up Studies",
- "Risk Factors",
- "Hypoglycemic Agents",
- "Adult",
- "Cause of Death",
- "China"
- ]
+ "Sleep"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "26"
+ }
},
{
- "PMID": "39720248",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Associations between non-insulin-based insulin resistance indices and diabetic nephropathy in patients with diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.",
- "Abstract": "Non-insulin-based insulin resistance indices are significantly associated with the risk of DN. The TyG index is a superior tool for assessing the risk of DN. These indices can assist in identifying patients at risk of DN, thereby enabling the implementation of more effective preventive and therapeutic strategies.",
+ "PMID": "39443044",
+ "Title": "Advances in anesthesia",
+ "ArticleTitle": "Perioperative Considerations for Patients on GLP1 Agonists.",
+ "Abstract": "GlP-1 receptor agonists are a class of medications that are becoming increasingly popular. Large trials have shown that their use provides reliable weight loss in obese patients and improved glycemic control in diabetic patients. Its use also has broader implications for overall metabolic health and has been shown to improve cardiovascular outcomes in high-risk populations. Glucagon-like peptide 1 receptors cause multiple effects in the body through stimulation of receptors expressed in a broad range of tissues including the pancreas, liver, gastrointestinal tract, kidneys, heart, endothelium, muscle, and brain. For the anesthesia professionals the effects of these medications on gastric emptying is important.",
"Predictions": [
- "Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Insulin Resistance",
- "Male",
- "Cross-Sectional Studies",
- "Female",
- "Diabetic Nephropathies",
- "Middle Aged",
- "Nutrition Surveys",
- "United States",
- "Adult",
- "Aged",
- "Risk Factors",
- "Diabetes Mellitus",
+ "Perioperative Care",
+ "Hypoglycemic Agents",
+ "Obesity",
+ "Glucagon-Like Peptide 1",
+ "Gastric Emptying",
"Diabetes Mellitus, Type 2",
- "Body Mass Index"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "24"
+ }
},
{
- "PMID": "39720247",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis.",
- "Abstract": "Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient insulin secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, the prevalence of T2DM has shown a sharp rise due to profound changes in socio-economic structure, the persistent influence of environmental factors, and the complex role of genetic background. It is worth noting that most T2DM patients show significant IR, which further exacerbates the difficulty of disease progression and prevention. In the process of extensively exploring the pathogenesis of T2DM, the dynamic equilibrium of gut microbes and its diverse metabolic activities have increasingly emphasized its central role in the pathophysiological process of T2DM. Bile acids (BAs) metabolism, as a crucial link between gut microbes and the development of T2DM, not only precisely regulates lipid absorption and metabolism but also profoundly influences glucose homeostasis and energy balance through intricate signaling pathways, thus playing a pivotal role in IR progression in T2DM. This review aims to delve into the specific mechanism through which BAs contribute to the development of IR in T2DM, especially emphasizing how gut microbes mediate the metabolic transformation of BAs based on current traditional Chinese medicine research. Ultimately, it seeks to offer new insights into the prevention and treatment of T2DM. Diet, genetics, and the environment intricately sculpt the gut microbiota and BAs metabolism, influencing T2DM-IR. The research has illuminated the significant impact of single herbal medicine, TCM formulae, and external therapeutic methods such as electroacupuncture on the BAs pool through perturbations in gut microbiota structure. This interaction affects glucose and lipid metabolism as well as insulin sensitivity. Additionally, multiple pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR signaling pathways have been identified through which the BAs pool significantly alter blood glucose levels and improve IR. These findings offer novel approaches for enhancing IR and managing metabolic disorders among patients with T2DM.",
+ "PMID": "39422617",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Heart rate variability indices for predicting cardiorenal outcomes: A lesson from the PERL and ACCORD cohorts.",
+ "Abstract": "This commentary highlights the role of heart rate variability (HRV) indices in predicting diabetic kidney disease (DKD) progression, based on findings from the PERL and ACCORD trials. HRV-derived measures from routine ECGs are shown to be strong predictors of rapid kidney function decline in both type 1 and type 2 diabetes, suggesting their potential utility in identifying individuals at high risk for DKD and guiding early preventive interventions.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Heart Rate",
+ "Diabetic Nephropathies",
"Diabetes Mellitus, Type 2",
- "Gastrointestinal Microbiome",
- "Insulin Resistance",
- "Bile Acids and Salts",
- "Medicine, Chinese Traditional",
- "Precision Medicine",
- "Animals"
- ]
+ "Prognosis",
+ "Disease Progression",
+ "Electrocardiography",
+ "Cohort Studies"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "18"
+ }
},
{
- "PMID": "39720175",
- "Title": "Journal of medicine and life",
- "ArticleTitle": "The impact of patient support and health education on diabetes management and glycemic control.",
- "Abstract": "Diabetes mellitus is a chronic and complex medical condition that can lead to significant morbidity and mortality. Maintaining an adequate blood glucose level is important for patients with diabetes, and to improve glycemic control, patients need proper support and health education, which are essential components of comprehensive diabetes care. We used a rigorous approach based on the PRISMA and Cochrane Handbook principles, specifically focusing on randomized controlled trials (RCTs) published in English from 2005 onwards. The statistical analysis was conducted using the RevMan software. Pooled risk ratios were calculated for dichotomous data, whereas mean differences were calculated for continuous data. Heterogeneity and publication bias were also evaluated. From an initial pool of 544 records, 368 studies were examined after eliminating duplicates. Ultimately, 24 studies were deemed suitable based on the inclusion criteria. These studies involved 2437 participants in the intervention group and 2305 people in the control group. The quality assessment indicated that 41.7% of the studies were categorized as low risk, 16.7% as high risk, and 41.7% had certain concerns regarding bias. The analyses revealed noteworthy decreases in HbA1c levels in the intervention group at several time points, particularly showing improvements after 3 months. Egger's regression indicated the presence of possible publication bias. The results emphasize the crucial impact of health education and mentorship interventions on enhancing glycemic control in individuals with type 2 diabetes. Interventions focused on empowering patients proved to be especially effective in enhancing diabetes management outcomes.",
+ "PMID": "39412809",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Characterizing GLP-1 Receptor Agonist Use in Preadolescent and Adolescent Populations.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Glycemic Control",
+ "Adolescent",
+ "Child",
+ "Male",
+ "Female",
+ "Hypoglycemic Agents",
"Diabetes Mellitus, Type 2",
- "Health Education",
- "Glycated Hemoglobin",
- "Blood Glucose",
- "Patient Education as Topic"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39720174",
- "Title": "Journal of medicine and life",
- "ArticleTitle": "Impact of type 2 diabetes mellitus on the prevalence of apical periodontitis in endodontically treated and untreated teeth.",
- "Abstract": "Apical periodontitis (AP) is a common dental condition that can be influenced by diabetes mellitus. This study aimed to investigate the impact of type 2 diabetes mellitus (T2DM) on the prevalence and severity of AP, considering the adequacy of endodontic treatments. A total of 180 patients selected based on specific dental criteria from a private clinic in Oradea, Romania, were included in this study. Clinical data were collected through medical records and panoramic radiographs. Statistical analyses were conducted using SPSS software, employing the Fisher test, Mann-Whitney test, and binary logistic regression to determine correlations between T2DM and AP in both endodontically treated and non-treated teeth. Additionally, we examined the relationship between diabetes and AP in teeth that received adequate root canal treatment (RCT), as well as the correlation of AP with the adequacy of endodontic treatment. Non-treated teeth were significantly more likely to have AP in patients with T2DM than in non-diabetic patients (OR = 5.3, ",
+ "PMID": "39407403",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Extended duration linagliptin nanoparticles: a novel, safe and effective future of diabetes treatment?",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Periapical Periodontitis",
+ "Linagliptin",
+ "Nanoparticles",
+ "Hypoglycemic Agents",
"Diabetes Mellitus, Type 2",
- "Prevalence",
- "Male",
- "Female",
- "Middle Aged",
- "Root Canal Therapy",
- "Adult",
- "Romania",
- "Tooth, Nonvital",
- "Aged"
- ]
- },
- {
- "PMID": "39719839",
- "Title": "Shanghai kou qiang yi xue = Shanghai journal of stomatology",
- "ArticleTitle": "[Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis].",
- "Abstract": "TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis, and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.",
- "Predictions": [
- "Diabetes type 2"
+ "Delayed-Action Preparations",
+ "Dipeptidyl-Peptidase IV Inhibitors"
],
- "MeshTerms": [
- "Humans",
- "TNF-Related Apoptosis-Inducing Ligand",
- "Diabetes Mellitus, Type 2",
- "Periodontitis",
- "Genetic Predisposition to Disease",
- "Polymorphism, Single Nucleotide",
- "Gene Frequency",
- "Genotype",
- "Blood Glucose",
- "Polymorphism, Genetic",
- "Glycated Hemoglobin"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39719724",
- "Title": "Clinical nutrition (Edinburgh, Scotland)",
- "ArticleTitle": "Effects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial.",
- "Abstract": "This study was registered on the website of www.chictr.org.cn, number ChiCTR2100052187.",
+ "PMID": "39406587",
+ "Title": "Advances in biological regulation",
+ "ArticleTitle": "Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology.",
+ "Abstract": "PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals, PITPNC1 is expressed as two splice variants whilst in zebrafish is expressed from two separate genes. The two splice variants have different expression profiles with the long splice variant having a prominent role in the brain. Several physiological functions have been identified including neuronal and metabolic functions. PITPNC1 also plays a significant role in cancer and has been identified as a risk factor in type 2 diabetes. Here, we review our current understanding of PITPNC1 in cell physiology and pathology.",
"Predictions": [
+ "Cancer",
"Diabetes type 2"
],
"MeshTerms": [
+ "Animals",
"Humans",
+ "Neoplasms",
+ "Phosphatidylinositols",
+ "Zebrafish",
"Diabetes Mellitus, Type 2",
- "Synbiotics",
- "Double-Blind Method",
- "Male",
- "Middle Aged",
- "Female",
- "Probiotics",
- "Blood Glucose",
- "Gastrointestinal Microbiome",
- "Glycated Hemoglobin",
- "Bifidobacterium animalis",
- "Insulin Resistance",
- "Treatment Outcome",
- "Insulin"
- ]
+ "Brain"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39719658",
- "Title": "European journal of medical research",
- "ArticleTitle": "The association between sodium-glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: a propensity-matched study.",
- "Abstract": "New use of SGLT2i during CA or PCI was not associated with an AKIN-defined CA-AKI, and it did not translate into new-onset dialysis or death during hospital stay. Chronic usage of SGLT2i did not affect creatinine. Further randomized clinical trials are warranted to confirm this finding.",
+ "PMID": "39390170",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Acute Kidney Injury",
+ "Myocardial Infarction",
+ "Prognosis",
"Sodium-Glucose Transporter 2 Inhibitors",
- "Male",
- "Female",
- "Middle Aged",
- "Diabetes Mellitus, Type 2",
- "Contrast Media",
- "Aged",
- "Coronary Angiography",
- "Propensity Score",
- "Percutaneous Coronary Intervention",
- "Creatinine",
- "China",
- "Incidence",
- "Retrospective Studies"
- ]
+ "Diabetes Mellitus, Type 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39719583",
- "Title": "BMC endocrine disorders",
- "ArticleTitle": "Evaluation and comparison of efficacy and safety of tirzepatide, liraglutide and SGLT2i in patients with type 2 diabetes mellitus: a network meta-analysis.",
- "Abstract": "Out of the seven medications examined in this study, tirzepatide demonstrates the most effective antidiabetic and weight-reducing effects. Furthermore, the dosage of Liraglutide at 1.2 mg and above demonstrates a more pronounced hypoglycemic effect in comparison to SGLT2 inhibitors. SGLT2 inhibitors exhibit a distinct hypotensive effect and are suitable for diabetic individuals experiencing hypertension.",
+ "PMID": "39390166",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Liraglutide",
- "Sodium-Glucose Transporter 2 Inhibitors",
- "Network Meta-Analysis",
- "Hypoglycemic Agents",
- "Randomized Controlled Trials as Topic",
- "Treatment Outcome",
- "Glucosides",
- "Glycated Hemoglobin",
- "Blood Glucose",
- "Glucagon-Like Peptide-2 Receptor",
- "Gastric Inhibitory Polypeptide",
- "Tirzepatide"
- ]
+ "Germany",
+ "Patient Education as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "11"
+ }
},
{
- "PMID": "39719404",
- "Title": "Journal of the American Heart Association",
- "ArticleTitle": "Atherothrombotic Outcomes After Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes: A Territory-Wide Retrospective Cohort Study.",
- "Abstract": "SGLT2 inhibitors in patients with diabetes were independently associated with reduction in atherothrombotic major adverse cardiovascular events, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, and incident dialysis, compared with DPP-4 inhibitors.",
+ "PMID": "39371922",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Glucagon-like peptide-1 receptor agonists in neoplastic diseases.",
+ "Abstract": "Glucagon-like peptide-1 receptor agonist (GLP-1RA), a novel hypoglycemic agent for the treatment of type 2 diabetes, has well-known effects such as lowering blood sugar, ameliorating inflammation, reducing weight, and lowering blood lipids. It has also been shown that it can influence the proliferation and survival of cells and has a certain effect on the prognosis of some neoplastic diseases. In this study, the potential effects of GLP-1RAs on the occurrence and development of tumors were reviewed to provide new ideas for the prevention and treatment of tumors in patients.",
"Predictions": [
+ "Cancer",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Dipeptidyl-Peptidase IV Inhibitors",
- "Male",
+ "Neoplasms",
+ "Hypoglycemic Agents",
+ "Animals",
"Diabetes Mellitus, Type 2",
- "Female",
- "Middle Aged",
- "Sodium-Glucose Transporter 2 Inhibitors",
- "Retrospective Studies",
- "Aged",
- "Hong Kong",
- "Treatment Outcome",
- "Risk Factors",
- "Risk Assessment",
- "Myocardial Infarction",
- "Thrombosis",
- "Time Factors",
- "Stroke"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "7"
+ }
},
{
- "PMID": "39719391",
- "Title": "BMJ open diabetes research & care",
- "ArticleTitle": "Differential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes: potential for more personalized interventions.",
- "Abstract": "Carbohydrate intake, sleep and physical activity at specific points in time have both fixed as well as individualized effects on glucose concentrations 2 hours later in individuals with type 2 diabetes. Interindividual differences in glycemic response to lifestyle components call for personalized advice in the management of type 2 diabetes.",
+ "PMID": "39368815",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[The experience of being diagnosed with type 2 diabetes in primary care].",
+ "Abstract": "The announcement of diabetes can be an ordeal for the person learning about it, and a difficult time for the doctor notifying them. By setting up a multi-professional team, we can offer personalized nursing support. This meets patients' expectations. These include reassurance, sufficient time to obtain answers to their questions, the ability to plan ahead, and the understanding that they have a say in their own health.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Male",
- "Female",
- "Middle Aged",
- "Blood Glucose",
- "Life Style",
- "Exercise",
- "Aged",
- "Sleep",
- "Hypoglycemic Agents",
- "Follow-Up Studies",
- "Precision Medicine",
- "Adult",
- "Biomarkers",
- "Prognosis"
- ]
+ "Primary Health Care"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39719314",
- "Title": "BMJ open diabetes research & care",
- "ArticleTitle": "Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia.",
- "Abstract": "Insulin sensitivity, secretion, and clearance differ significantly in normoglycemic African American versus European American offspring of parents with type 2 diabetes and are associated with the risk of incident dysglycemia.",
+ "PMID": "39366641",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Role of epicardial adipose tissue in cardiac remodeling.",
+ "Abstract": "Epicardial adipose tissue, or epicardial fat, is a type of visceral fat located between the heart and the pericardium. Due to its anatomical proximity to the heart, EAT plays a significant role in both cardiac physiology and pathologies, including cardiac remodeling and cardiovascular diseases (CVD). However, our understanding of how EAT pathology is influenced by risk factors such as obesity and type 2 diabetes mellitus and how altered EAT can drive cardiac remodeling and CVD, remains limited. Herein, we aimed to summarize and discuss the latest findings on EAT and its role in cardiac remodeling, highlighting the outcomes of clinical and observational studies, provide mechanistic insights, and finally introduce emerging therapeutic agents and nutritional guidelines aimed at preventing these conditions.",
"Predictions": [
+ "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
- "Adult",
- "Female",
"Humans",
- "Male",
- "Middle Aged",
- "Biomarkers",
- "Black or African American",
- "Blood Glucose",
+ "Pericardium",
+ "Adipose Tissue",
+ "Ventricular Remodeling",
"Diabetes Mellitus, Type 2",
- "Follow-Up Studies",
- "Glucose Clamp Technique",
- "Glucose Tolerance Test",
- "Incidence",
- "Insulin",
- "Insulin Resistance",
- "Insulin Secretion",
- "Parents",
- "Prediabetic State",
- "Prognosis",
- "Prospective Studies",
- "White"
- ]
+ "Cardiovascular Diseases",
+ "Obesity",
+ "Intra-Abdominal Fat",
+ "Epicardial Adipose Tissue"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39719282",
- "Title": "BMJ open",
- "ArticleTitle": "Theory-based behaviour modification of Asian adults with type-2 diabetes mellitus after participating in a novel telemonitoring system: a qualitative research study.",
- "Abstract": "NCT04306770.",
+ "PMID": "39365623",
+ "Title": "Folia medica",
+ "ArticleTitle": "Expression of ten-eleven translocation 2 and glutathione-S-transferase pi in colorectal cancer patients with and without type 2 diabetes mellitus.",
+ "Abstract": "To highlight possible correlations of type 2 diabetes mellitus (T2DM) with microscopic / macroscopic characteristics of colorectal cancer tissues, along with the expression of Ten-Eleven Translocation 2 (TET2) and glutathione-S-transferase pi (GST-pi) proteins.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
+ "Colorectal Neoplasms",
"Male",
+ "Glutathione S-Transferase pi",
"Female",
"Middle Aged",
- "Qualitative Research",
- "Singapore",
- "Telemedicine",
- "Adult",
- "Self Efficacy",
"Aged",
- "Health Behavior",
- "Asian People",
- "Blood Glucose",
- "Blood Glucose Self-Monitoring",
- "Blood Pressure"
- ]
+ "Dioxygenases",
+ "DNA-Binding Proteins",
+ "Proto-Oncogene Proteins",
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39719183",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD.",
- "Abstract": "NAFLD-non-MASLD patients with 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L are still at high risk of poor clinical outcomes. These findings support including 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L as a component of the metabolic dysfunction definition.",
+ "PMID": "39362732",
+ "Title": "The American journal of clinical nutrition",
+ "ArticleTitle": "Polymorphism of vitamin D receptor and risk of infections in type 2 diabetes.",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Middle Aged",
- "Non-alcoholic Fatty Liver Disease",
- "Blood Glucose",
- "Retrospective Studies",
- "Glucose Tolerance Test",
- "Adult",
- "Aged",
- "Cardiovascular Diseases",
+ "Diabetes Mellitus, Type 2",
+ "Receptors, Calcitriol",
"Risk Factors",
- "Diabetes Mellitus, Type 2"
- ]
+ "Polymorphism, Genetic",
+ "Polymorphism, Single Nucleotide",
+ "Genetic Predisposition to Disease"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39719182",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study.",
- "Abstract": "YKL-40 is a prognostic biomarker for most CVEs, and even more so for all-cause mortality, primarily driven by cancer-related causes.",
+ "PMID": "39358050",
+ "Title": "Trends in biochemical sciences",
+ "ArticleTitle": "Bridging brain insulin resistance to Alzheimer's pathogenesis.",
+ "Abstract": "Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3\u03b2 (GSK3\u03b2) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
+ "Alzheimer Disease",
+ "Insulin Resistance",
"Humans",
+ "Brain",
"Diabetes Mellitus, Type 2",
- "Chitinase-3-Like Protein 1",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Denmark",
- "Cardiovascular Diseases",
- "Biomarkers",
- "Cohort Studies",
- "C-Reactive Protein"
- ]
+ "Oxidoreductases Acting on CH-CH Group Donors",
+ "Glycogen Synthase Kinase 3 beta",
+ "Animals",
+ "Mitochondria",
+ "Phosphorylation",
+ "Glycogen Synthase Kinase 3"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39719170",
- "Title": "Metabolism: clinical and experimental",
- "ArticleTitle": "Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis.",
- "Abstract": "Potent GLP-1 RAs, such as tirzepatide and semaglutide, demonstrate greater overall weight loss but are associated with a significant reduction in lean mass.",
+ "PMID": "39356417",
+ "Title": "Journal of nephrology",
+ "ArticleTitle": "Management of acute kidney disease in type 2 diabetes: the potential role of GLP-1 RAs and SGLT2-Is.",
+ "Abstract": "Acute kidney disease (AKD) is defined as subacute damage and/or loss of kidney function occurring 7 to 90\u00a0days after acute kidney injury (AKI), and bearing a high risk of progression to chronic kidney disease. Current management of AKD is non-specific and includes prevention of repeated AKI, early and regular follow-up by a nephrologist, resumption and dose adjustment of statins and renin-angiotensin system inhibitors, optimization of blood pressure control, nutrition management, and nephrotoxin avoidance. Recently, SGLT2i and GLP1- RAs have emerged as potential therapeutic tools preventing the transition from acute to chronic kidney disease due to their efficacy in preserving renal function.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Glucagon-Like Peptide-1 Receptor",
- "Body Composition",
- "Network Meta-Analysis as Topic",
- "Obesity",
- "Hypoglycemic Agents",
- "Randomized Controlled Trials as Topic",
- "Receptors, Gastrointestinal Hormone",
+ "Sodium-Glucose Transporter 2 Inhibitors",
"Diabetes Mellitus, Type 2",
+ "Acute Kidney Injury",
+ "Renin-Angiotensin System",
+ "Diabetic Nephropathies",
+ "Glucagon-Like Peptide 1",
+ "Disease Progression",
+ "Incretins",
"Glucagon-Like Peptide-1 Receptor Agonists"
- ]
- },
- {
- "PMID": "39719165",
- "Title": "Life sciences",
- "ArticleTitle": "Semaglutide alleviates the pancreatic \u03b2 cell function via the METTL14 signaling and modulating gut microbiota in type 2 diabetes mellitus mice.",
- "Abstract": "Semaglutide positively influences by regulating m6A modifications to alleviate pancreatic beta cell dysfunction and modulate the gut microbiome.",
- "Predictions": [
- "Diabetes type 2"
],
- "MeshTerms": [
- "Animals",
- "Insulin-Secreting Cells",
- "Male",
- "Glucagon-Like Peptides",
- "Mice",
- "Gastrointestinal Microbiome",
- "Mice, Inbred C57BL",
- "Diabetes Mellitus, Type 2",
- "Signal Transduction",
- "Diabetes Mellitus, Experimental",
- "Methyltransferases",
- "Diet, High-Fat",
- "Hypoglycemic Agents"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "2"
+ }
},
{
- "PMID": "39718468",
- "Title": "Endocrinology, diabetes & metabolism",
- "ArticleTitle": "Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial.",
- "Abstract": "Reduction in liver fat content effectively improves pancreatic islet function secretion, particularly postprandial c-peptide secretion, especially in the first hour after a meal. This improvement leads to a decrease in glycated haemoglobin levels and promotes better compliance with blood glucose control.",
+ "PMID": "39350058",
+ "Title": "BMC infectious diseases",
+ "ArticleTitle": "A case of human diarrhea caused by Gallibacterium anatis: a case report.",
+ "Abstract": "Gallibacterium anatis (G. anatis) is an opportunistic pathogen previously associated with deaths in poultry and is also a pathogen that rarely causes human diseases. G. anatis has only been reported twice as the causative agent of a human disease (both in France). Here, we report a 62-year-old male patient with hypertension and type 2 diabetes who suffered from acute watery diarrhea caused by this bacterium which was identified by MALDI-TOF MS and 16\u00a0S rRNA sequencing. Despite human diarrhea caused by G.anatis is rare, with the continuous emergence of multidrug-resistant isolates of G. anatis in recent years, this case report will inform clinicians that G. anatis especially drug-resistant G. anatis may be a possible infectious source of human diarrhea in immune-suppressed populations.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Male",
- "Female",
+ "Diarrhea",
"Middle Aged",
+ "Pasteurellaceae Infections",
+ "RNA, Ribosomal, 16S",
+ "Pasteurellaceae",
"Diabetes Mellitus, Type 2",
- "Glucagon-Like Peptides",
- "Immunoglobulin Fc Fragments",
- "Liver",
- "Recombinant Fusion Proteins",
- "Hypoglycemic Agents",
- "Adult",
- "Non-alcoholic Fatty Liver Disease",
- "Aged",
- "Glycated Hemoglobin",
- "Blood Glucose",
- "Cohort Studies",
- "Treatment Outcome"
- ]
+ "Anti-Bacterial Agents",
+ "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization",
+ "Hypertension"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "1"
+ }
},
{
- "PMID": "39718016",
- "Title": "Adipocyte",
- "ArticleTitle": "Correlation analysis of key genes and immune infiltration in visceral adipose tissue and subcutaneous adipose tissue of patients with type 2 diabetes in women.",
- "Abstract": "Immune cell infiltration into adipose tissue (AT) is a key factor in type 2 diabetes (T2DM). However, research on the impact of fat distribution on immune cells and immune responses in women is still lacking. This study used enrichment, protein-protein interaction network, immune cell infiltration, and correlation analysis to compare the similarities and differences between the transcriptome data of visceral AT (VAT) and subcutprotein-proteinaneous AT (SAT) obtained from the omprehensive database of gene expression in women with non-T2DM and T2DM. DEGs with the same biological function in two types of ATs often exhibited different expression trends. SharedVAT-specific and SAT-specific hub genes were mainly associated with transcription factors, monocyte-macrophage markers, and chemokines, respectively. Immune cells affected by both AT types included monocytes, granulocytes, T and B lymphocytes, and NK cells. VAT affected more immune cells, mainly myeloid cells. Shared hub genes in VAT correlated positively with M1 macrophages, suggesting pro-inflammatory effects, while those in SAT correlated negatively with M1 macrophages and lymphocytes, suggesting anti-inflammatory effects. This study provides a theoretical basis for further understanding the correlation between AT and T2DM in women.",
+ "PMID": "39344197",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "Maturity-onset diabetes of the young: A\u00a0proposal for updated nomenclature.",
+ "Abstract": "Given the contemporary understanding of diabetes genetics, the term \"maturity-onset diabetes of the young (MODY)\" warrants renaming. I propose adopting the term \"monogenic diabetes\" in conjunction with the specific gene name.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Female",
- "Intra-Abdominal Fat",
- "Subcutaneous Fat",
- "Transcriptome",
- "Gene Expression Profiling",
- "Macrophages",
- "Protein Interaction Maps"
- ]
+ "Terminology as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "30"
+ }
},
{
- "PMID": "39717954",
- "Title": "Molecular medicine reports",
- "ArticleTitle": "Insights into renal damage in hyperuricemia: Focus on renal protection (Review).",
- "Abstract": "The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction\u2011associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage. A number of randomized controlled clinical trials have investigated the effectiveness of UA\u2011lowering therapies in preventing kidney disease progression. The present review provided fundamental insights into the pathogenesis, principles and therapeutic approaches for managing hyperuricemia in patients with aforementioned diseases and assesses the effect of uric acid\u2011lowering therapy on diabetic nephropathy, systemic lupus erythematosus, CKD, CVD and obesity progression.",
+ "PMID": "39342567",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Type 2 diabetes and Alzheimer's disease - are there common microbial roots?].",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Hyperuricemia",
- "Uric Acid",
- "Renal Insufficiency, Chronic",
- "Kidney",
- "Animals",
- "Obesity",
+ "Alzheimer Disease",
"Diabetes Mellitus, Type 2",
- "Cardiovascular Diseases",
- "Gout"
- ]
+ "Insulin Resistance",
+ "Gastrointestinal Microbiome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "29"
+ }
},
{
- "PMID": "39717105",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Risk factor screening and prediction modeling of gastrointestinal adverse reactions caused by GLP-1RAs.",
- "Abstract": "The established nomogram model has an excellent predictive effect on GISEs induced by GLP-1RAs in patients with T2DM.",
+ "PMID": "39342034",
+ "Title": "Innere Medizin (Heidelberg, Germany)",
+ "ArticleTitle": "[Striking manifestation and unexpected therapeutic course of diabetes mellitus in a\u00a022-year-old male patient].",
+ "Abstract": "The case of a\u00a022-year-old male patient who presented with acute on chronic hyperglycemia in known MODY (\"maturity onset diabetes of the young\") 12 (ABCC8 gene) after 11\u00a0months of treatment cessation is reported. To emphasize the importance of the awareness of this therapeutically important entity of diabetes, the essential facts of this inherited disease are summarized.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Female",
"Male",
- "Middle Aged",
+ "Young Adult",
"Diabetes Mellitus, Type 2",
- "Risk Factors",
- "Gastrointestinal Diseases",
- "Nomograms",
- "Aged",
"Hypoglycemic Agents",
- "Adult",
- "Prognosis",
- "Glucagon-Like Peptide-1 Receptor Agonists"
- ]
+ "Sulfonylurea Receptors",
+ "Hyperglycemia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "29"
+ }
},
{
- "PMID": "39716666",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Association of Novel Clinical and Behavioural Markers with HbA1c Improvement: A Latent Class Analysis of 912 Patients with Type 2 Diabetes Mellitus.",
- "Abstract": "Individuals with higher baseline HbA1c, education, motivation, and activity levels experienced the most significant HbA1c reductions in response to lifestyle interventions. A tailored approach to these modifiable characteristics may help patients achieve substantial 12-month HbA1c reductions.",
+ "PMID": "39340438",
+ "Title": "Diabetes, obesity & metabolism",
+ "ArticleTitle": "Sodium-glucose\u2009co-transporter-2 inhibitors: A paradigm shift in treatment for type 2 diabetes.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Glycated Hemoglobin",
- "Male",
- "Female",
- "Middle Aged",
- "Latent Class Analysis",
- "Prospective Studies",
- "Aged",
- "Exercise",
- "Adult",
- "Motivation",
- "Singapore",
- "Educational Status",
- "Life Style",
- "Biomarkers"
- ]
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Hypoglycemic Agents",
+ "Sodium-Glucose Transporter 2",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "28"
+ }
},
{
- "PMID": "39716481",
- "Title": "Clinical science (London, England : 1979)",
- "ArticleTitle": "Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge.",
- "Abstract": "Chronic inflammatory diseases, e.g., obesity, cardiovascular disease and type-2 diabetes, progressively suppress the anti-inflammatory heat shock response (HSR) by impairing the synthesis of key components, perpetuating inflammation. Monitoring HSR progression offers predictive value for countering chronic inflammation. This study quantified HSR in high-fat diet (HFD) and normal chow (NC) mice by measuring 70 kDa heat shock protein (HSP70) expression after heat treatment of whole blood samples. To align with human translational relevance, animals were housed within their thermoneutral zone (TNZ). Whole blood was heat-challenged weekly at 42 \u00b0C for 1-2 hours over 22 weeks, and \u0394HSP70 was calculated as the difference between HSP70 expressions at 42 \u00b0C and 37 \u00b0C. Results correlated with fasting glycaemia, oral glucose tolerance test, intraperitoneal insulin tolerance test and 2-hour post-glucose load glycaemia. \u0394HSP70 levels >0.2250 indicated normal fasting glycaemia, while levels <0.2125 signalled insulin resistance and type-2 diabetes onset. A logistic model (five-parameter logistic) showed progressive HSR decline, with HFD mice exhibiting earlier \u0394HSP70 reduction (t1/2 = 3.14 weeks) compared with NC mice (t1/2 = 8.24 weeks), highlighting compromised anti-inflammatory capacity in both groups of mice maintained at TNZ. Remarkably, even NC mice surpassed insulin resistance thresholds by week 22, relevant as control diets confronted interventions. Observed HSR decline mirrors tissue-level suppression in obese and type-2 diabetic individuals, underscoring HSR failure as a hallmark of obesity-driven inflammation. This study introduces a practical whole-blood assay to evaluate HSR suppression, allowing assessment of glycaemic status during obesity onset before any clinical manifestation.",
+ "PMID": "39325062",
+ "Title": "Diabetes & vascular disease research",
+ "ArticleTitle": "MicroRNA-451a downregulation in liraglutide-treated individuals with diabetes: A potential cardiovascular protective mechanism.",
+ "Abstract": "",
"Predictions": [
+ "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Insulin Resistance",
- "Heat-Shock Response",
+ "Female",
+ "Humans",
"Male",
- "Diet, High-Fat",
- "Mice, Inbred C57BL",
- "HSP70 Heat-Shock Proteins",
- "Disease Progression",
+ "Middle Aged",
"Blood Glucose",
- "Mice",
- "Hot Temperature",
- "Early Diagnosis",
+ "Cardiovascular Diseases",
"Diabetes Mellitus, Type 2",
- "Obesity",
- "Inflammation"
- ]
+ "Down-Regulation",
+ "Hypoglycemic Agents",
+ "Incretins",
+ "Liraglutide",
+ "MicroRNAs",
+ "Treatment Outcome"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "26"
+ }
},
{
- "PMID": "39716335",
- "Title": "Journal of neuroinflammation",
- "ArticleTitle": "Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes.",
- "Abstract": "Treg modulation in T2D offers a promising therapeutic approach to prevent early stages of DR. This strategy focuses on reducing neuroinflammation and mitigating the associated neuronal, glial, and vascular degenerative changes characteristic of DR.",
+ "PMID": "39322888",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Mice",
- "T-Lymphocytes, Regulatory",
+ "Humans",
"Diabetes Mellitus, Type 2",
- "Retinal Degeneration",
- "Mice, Inbred C57BL",
- "Male",
- "Diabetic Retinopathy",
- "Retina"
- ]
+ "Hypoglycemic Agents",
+ "Thyroid Neoplasms",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "26"
+ }
},
{
- "PMID": "39716328",
- "Title": "Alzheimer's research & therapy",
- "ArticleTitle": "Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials.",
- "Abstract": "Compared with non-users, SGLT-2i, GLP-1RA, TZD and metformin were associated with the reduced risk of dementia in patients with T2D. SGLT-2i, and GLP-1RA may serve as the optimal choice to improve the cognitive prognosis in patients with T2D.",
+ "PMID": "39322879",
+ "Title": "MMW Fortschritte der Medizin",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "",
"Predictions": [
+ "Cancer",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Dementia",
"Diabetes Mellitus, Type 2",
- "Hypoglycemic Agents",
- "Network Meta-Analysis",
- "Observational Studies as Topic",
- "Randomized Controlled Trials as Topic",
- "Sodium-Glucose Transporter 2 Inhibitors"
- ]
+ "Neoplasms",
+ "Risk Factors",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "26"
+ }
},
{
- "PMID": "39716288",
- "Title": "The international journal of behavioral nutrition and physical activity",
- "ArticleTitle": "The efficacy of using continuous glucose monitoring as a behaviour change tool in populations with and without diabetes: a systematic review and meta-analysis of randomised controlled trials.",
- "Abstract": "CRD42024514135.",
+ "PMID": "39320894",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Semaglutide and Opioid Overdose Risk in Patients With Type 2 Diabetes and Opioid Use Disorder.",
+ "Abstract": "",
"Predictions": [
- "Diabetes type 1",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Randomized Controlled Trials as Topic",
- "Blood Glucose Self-Monitoring",
"Diabetes Mellitus, Type 2",
- "Blood Glucose",
- "Exercise",
- "Health Behavior",
- "Diabetes Mellitus, Type 1",
"Female",
- "Adult",
- "Glycated Hemoglobin",
- "Pregnancy",
- "Continuous Glucose Monitoring"
- ]
+ "Male",
+ "Middle Aged",
+ "Glucagon-Like Peptides",
+ "Opiate Overdose",
+ "Opioid-Related Disorders",
+ "Hypoglycemic Agents",
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "25"
+ }
},
{
- "PMID": "39716258",
- "Title": "Lipids in health and disease",
- "ArticleTitle": "The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.",
- "Abstract": "Overall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.",
+ "PMID": "39320205",
+ "Title": "Studies in health technology and informatics",
+ "ArticleTitle": "A Temporospatial Analysis of Activity Patterns for Fall Risk Assessment in Older Adults with Comorbid Type 2 Diabetes.",
+ "Abstract": "This study explores how daily activities, including duration and location within the home, affect fall risk in older adults with type 2 diabetes. Body-worn cameras on 26 participants provided data on activity (e.g. exercise), time and location (kitchen, living room). Demographics and health factors were considered to understand their influence. By visualising activity patterns, this study aimed to identify behaviours linked to falls to inform personalised fall prevention strategies and digital technologies for independent living.",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Biomarkers",
- "Blood Glucose",
- "Cardiovascular Diseases",
- "Cross-Sectional Studies",
+ "Accidental Falls",
"Diabetes Mellitus, Type 2",
- "Insulin Resistance",
- "Metabolic Syndrome",
- "Triglycerides"
- ]
+ "Aged",
+ "Risk Assessment",
+ "Male",
+ "Female",
+ "Activities of Daily Living",
+ "Spatio-Temporal Analysis",
+ "Comorbidity",
+ "Independent Living",
+ "Aged, 80 and over",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "25"
+ }
},
{
- "PMID": "39716230",
- "Title": "Journal of medical case reports",
- "ArticleTitle": "Applying auricular magnetic therapy to decrease blood glucose levels and promote the healing of gangrene in diabetes patients: a case report.",
- "Abstract": "Auricular static magnetic therapy has demonstrated efficacy as a beneficial treatment for diabetes. This therapeutic approach has been shown to reduce blood glucose levels, increase blood circulation, and promote gangrene healing. Its noninvasive nature, rapid onset of action, and cost-effectiveness are notable attributes. The novel contribution of this case report resides in its potential application as a complementary therapy for diabetes utilized in conjunction with conventional Western medical practices.",
+ "PMID": "39316579",
+ "Title": "Pharmaceutical patent analyst",
+ "ArticleTitle": "Liraglutide innovations: a comprehensive review of patents (2014-2024).",
+ "Abstract": "Type-2 diabetes mellitus (T2DM) is a complicated long-term disorder associated with metabolism that is identified by insulin resistance, imbalance in glucose regulation and reduced secretion of insulin. GLP-1(Glucagon-like peptide-1) is an incretin mimetic that has excellent effects on the regulation of blood glucose levels and also the management of disorders associated with vital organs. GLP-1 agonist is an effective class of drug for the treatment of type-2 diabetes mellitus and associated complications. Liraglutide is one of the potent drugs of this class having similar effects as biological GLP-1. This review includes clinical trials and patents related to the pharmaceutical formulation, synthesis and biological action of liraglutide.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Liraglutide",
+ "Patents as Topic",
"Humans",
- "Male",
- "Middle Aged",
- "Gangrene",
"Diabetes Mellitus, Type 2",
- "Blood Glucose",
- "Acupuncture, Ear",
- "Wound Healing",
- "Treatment Outcome",
- "Amputation, Surgical",
- "Acupuncture Points",
- "Magnetic Field Therapy"
- ]
+ "Hypoglycemic Agents",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39716081",
- "Title": "Molecular medicine (Cambridge, Mass.)",
- "ArticleTitle": "Uncovering the molecular networks of ferroptosis in the pathogenesis of type 2 diabetes and its complications: a multi-omics investigation.",
- "Abstract": "This study identified FRGs in relation to T2D and its complications, which may enhance the understanding of the pathogenic mechanisms of their development. Meanwhile, it offers cross-validation for imaging genomics and further indicates the direction for non-invasive diagnosis.",
+ "PMID": "39315871",
+ "Title": "NEJM evidence",
+ "ArticleTitle": "Can SGLT2 Inhibitors ERASe Arrhythmias?",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Sodium-Glucose Transporter 2 Inhibitors",
"Humans",
+ "Arrhythmias, Cardiac",
"Diabetes Mellitus, Type 2",
- "Ferroptosis",
- "Gene Regulatory Networks",
- "Genetic Predisposition to Disease",
- "Genomics",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
+ },
+ {
+ "PMID": "39313235",
+ "Title": "Diabetes & metabolism journal",
+ "ArticleTitle": "Two-Year Therapeutic Efficacy and Safety of Initial Triple Combination of Metformin, Sitagliptin, and Empagliflozin in Drug-Na\u00efve Type 2 Diabetes Mellitus Patients (Diabetes Metab J 2024;48:253-64).",
+ "Abstract": "",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Glucosides",
+ "Metformin",
+ "Benzhydryl Compounds",
+ "Sitagliptin Phosphate",
+ "Hypoglycemic Agents",
+ "Drug Therapy, Combination",
+ "Treatment Outcome",
"Male",
- "Diabetes Complications",
"Female",
- "Gene Expression Profiling",
- "Polymorphism, Single Nucleotide",
- "Computational Biology",
- "Genetic Association Studies",
- "Multiomics"
- ]
+ "Middle Aged",
+ "Blood Glucose",
+ "Glycated Hemoglobin",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39716056",
- "Title": "BMC genomics",
- "ArticleTitle": "Evaluation of Bayesian Linear Regression derived gene set test methods.",
- "Abstract": "Comparing our method with other approaches, such as the gold standard MAGMA (Multi-marker Analysis of Genomic Annotation) approach, our BLR gene set test showed superior performance. Combining performance of our method in simulated and real phenotypes, this suggests that our BLR-based approach could more accurately identify genes and biological pathways underlying complex diseases.",
+ "PMID": "39313234",
+ "Title": "Diabetes & metabolism journal",
+ "ArticleTitle": "Construction of Risk Prediction Model of Type 2 Diabetic Kidney Disease Based on Deep Learning (Diabetes Metab J 2024;48:771-9).",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Bayes Theorem",
- "Diabetes Mellitus, Type 2",
"Humans",
- "Linear Models",
- "Linkage Disequilibrium",
- "Quantitative Trait Loci",
- "Phenotype",
- "Computer Simulation",
- "Models, Genetic",
- "Genome-Wide Association Study"
- ]
+ "Deep Learning",
+ "Diabetes Mellitus, Type 2",
+ "Diabetic Nephropathies",
+ "Risk Assessment",
+ "Risk Factors",
+ "Male",
+ "Female",
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39715944",
- "Title": "Obesity surgery",
- "ArticleTitle": "Diabetes Remission After\u00a0Bariatric\u00a0Surgery: A 10-Year Follow-Up Study.",
- "Abstract": "MBS can induce a significant improvement and sustainable remission of T2DM. Early intervention, while patients still have a good glycemic control with a lower number of anti-diabetic drugs, is crucial to achieve long-lasting benefits and a potential \"surgical cure\" for T2DM.",
+ "PMID": "39313233",
+ "Title": "Diabetes & metabolism journal",
+ "ArticleTitle": "Two-Year Therapeutic Efficacy and Safety of Initial Triple Combination of Metformin, Sitagliptin, and Empagliflozin in Drug-Na\u00efve Type 2 Diabetes Mellitus Patients (Diabetes Metab J 2024;48:253-64).",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Adult",
- "Female",
"Humans",
+ "Diabetes Mellitus, Type 2",
+ "Glucosides",
+ "Metformin",
+ "Benzhydryl Compounds",
+ "Sitagliptin Phosphate",
+ "Hypoglycemic Agents",
+ "Drug Therapy, Combination",
+ "Treatment Outcome",
"Male",
+ "Female",
"Middle Aged",
- "Bariatric Surgery",
"Blood Glucose",
- "Diabetes Mellitus, Type 2",
- "Follow-Up Studies",
"Glycated Hemoglobin",
- "Glycemic Control",
- "Hypoglycemic Agents",
- "Obesity, Morbid",
- "Recurrence",
- "Remission Induction",
- "Retrospective Studies",
- "Treatment Outcome",
- "Weight Loss"
- ]
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Aged"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39715341",
- "Title": "Endocrinology",
- "ArticleTitle": "GLP-1 and Its Analogs: Does Sex Matter?",
- "Abstract": "While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeutics, glucagon-like peptide 1 (GLP-1) analogs (eg, semaglutide), shows promise at curbing both diseases. This review addresses the topic of sex differences in the endogenous and therapeutic actions of GLP-1 and its analogs. Work on sex differences in human studies and animal research is reviewed. Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted. Moreover, recent clinical evidence of sex differences in the therapeutic effects of GLP-1 analogs in obesity, diabetes, and cardiovascular disease are discussed. Lastly, we review evidence for the role of GLP-1 analogs in mood and reproductive function, with particular attention to sex differences. Overall, while we did not find evidence for many qualitative sex differences in the therapeutic effect of clinically approved GLP-1 analogs, a growing body of literature highlights quantitative sex differences in the response to GLP-1 and its analogs as well as an interaction of these therapeutics with estrogens. What also clearly emerges is the paucity of data in female animal models or women in very basic aspects of the science of GLP-1-gaps that should be urgently mended, given the growing popularity of these medications, especially in women.",
+ "PMID": "39313232",
+ "Title": "Diabetes & metabolism journal",
+ "ArticleTitle": "Construction of Risk Prediction Model of Type 2 Diabetic Kidney Disease Based on Deep Learning (Diabetes Metab J 2024;48:771-9).",
+ "Abstract": "",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Glucagon-Like Peptide 1",
- "Animals",
- "Female",
+ "Deep Learning",
+ "Diabetes Mellitus, Type 2",
+ "Diabetic Nephropathies",
+ "Risk Assessment",
+ "Risk Factors",
"Male",
- "Sex Characteristics",
- "Obesity",
- "Glucagon-Like Peptides",
- "Hypoglycemic Agents",
- "Sex Factors",
- "Cardiovascular Diseases",
- "Diabetes Mellitus, Type 2"
- ]
+ "Female",
+ "Prognosis"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39715135",
- "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
- "ArticleTitle": "ABCC8 polymorphisms rs757110 and rs1801261 association with sulfonylurea therapy of Iraqi type 2 diabetics.",
- "Abstract": "Conclusions: The rs757110 related to less insulin excretion in T2DM of Iraqi Middle Euphrates population who received glimepiride and glibenclamide for diabetes treatment.",
+ "PMID": "39313231",
+ "Title": "Diabetes & metabolism journal",
+ "ArticleTitle": "Ideal Combination of Oral Hypoglycemic Agents for Patients with Type 2 Diabetes Mellitus.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Male",
- "Female",
- "Sulfonylurea Compounds",
- "Iraq",
- "Sulfonylurea Receptors",
- "Case-Control Studies",
- "Polymorphism, Single Nucleotide",
- "Middle Aged",
"Hypoglycemic Agents",
- "Adult"
- ]
+ "Drug Therapy, Combination",
+ "Administration, Oral",
+ "Blood Glucose"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "24"
+ }
},
{
- "PMID": "39713052",
- "Title": "Frontiers in endocrinology",
- "ArticleTitle": "Research progress on the relationship between free fatty acid profile and type 2 diabetes complicated by coronary heart disease.",
- "Abstract": "Patients with type 2 diabetes mellitus (T2DM) have a 2 to 3 times higher risk of cardiovascular disease compared to non-diabetic individuals, and cardiovascular disease has consistently been a leading cause of death among diabetic patients. Therefore, preventing cardiovascular disease in diabetic patients remains a significant challenge. In addition to classic indicators such as cholesterol and lipoproteins, previous studies have demonstrated that plasma level of free fatty acid (FFA) is closely related to the occurrence of atherosclerosis, particularly in T2DM patients. In recent years, with further research and advancements in testing technologies, the FFA profile has garnered widespread attention. The FFA profile includes many different types of FFAs, and changes in the plasma FFA profile and concentrations in T2DM patients may lead to the development of insulin resistance, causing damage to vascular endothelial cells and promoting the occurrence and progression of atherosclerosis. Furthermore, some FFAs have shown potential in predicting cardiovascular complications in T2DM and are associated with the severity of these complications. Here, we aim to review the changes in the FFA profile in T2DM and discuss the relationship between the FFA profile and the occurrence of vascular complications in T2DM.",
+ "PMID": "39311884",
+ "Title": "Journal of public health management and practice : JPHMP",
+ "ArticleTitle": "What Is the Role of Public Health in the Era of GLP-1 Receptor Agonists.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Public Health",
"Diabetes Mellitus, Type 2",
- "Fatty Acids, Nonesterified",
- "Coronary Disease",
- "Insulin Resistance"
- ]
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "23"
+ }
},
{
- "PMID": "39710901",
- "Title": "International ophthalmology clinics",
- "ArticleTitle": "Glucagon-like Peptide-1 Receptor Agonists in the Management of Diabetic Retinopathy.",
- "Abstract": "Glucagon-like peptide-1 (GLP-1) receptor agonists are a family of drugs, most well known by the third-generation once-weekly subcutaneous semaglutide, that act on the incretin pathway of metabolic, hormonal signaling to modulate pancreatic insulin release, gastric emptying, energy intake, and subjective feelings of satiety. This class of drugs' efficacy and safety in the treatment of type 2 diabetes and obesity have been demonstrated across multiple large randomized controlled trials. These data have propelled GLP-1 receptor agonists to ubiquity in diabetic management and weight loss therapy, leading them to be frequently encountered in ophthalmic practice. The effect of GLP-1 receptor agonists like semaglutide on diabetic retinopathy (DR) is at this point unclear; some studies indicate a worsening of DR with the initiation of GLP-1 agonists, especially semaglutide. Overall, the macrovascular reduction of cardiovascular and stroke risks from GLP-1 receptor agonists should be prioritized over the potential microvascular progression of DR, as long as the patient is regularly followed by ophthalmology.",
+ "PMID": "39301951",
+ "Title": "Pain management",
+ "ArticleTitle": "Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with Type 2 diabetes.",
+ "Abstract": "This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain. Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months. Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r\u00a0=\u00a00.73, \u00a0<\u00a00.001) was found between glycemic control and pain reduction. Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Diabetic Retinopathy",
+ "Immunoglobulin Fc Fragments",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Male",
+ "Recombinant Fusion Proteins",
+ "Aged",
"Glucagon-Like Peptides",
+ "Glycemic Control",
+ "Osteoarthritis, Knee",
"Hypoglycemic Agents",
- "Diabetes Mellitus, Type 2",
- "Glucagon-Like Peptide-1 Receptor Agonists"
- ]
+ "Middle Aged",
+ "Glycated Hemoglobin",
+ "Arthralgia",
+ "Treatment Outcome",
+ "Blood Glucose",
+ "Aged, 80 and over"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "21"
+ }
},
{
- "PMID": "39710882",
- "Title": "Obesity (Silver Spring, Md.)",
- "ArticleTitle": "GLP1Ra-based therapies and DXA-acquired musculoskeletal health outcomes: a focused meta-analysis of placebo-controlled trials.",
- "Abstract": "Approximately 30% of body weight lost with GLP1Ra-based therapy is LM. More data are needed assessing BMD outcomes.",
+ "PMID": "39300714",
+ "Title": "Current vascular pharmacology",
+ "ArticleTitle": "Antihypertensive Effects of SGLT2-Inhibitors: Considerations for Clinical Practice.",
+ "Abstract": "",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Bone Density",
- "Glucagon-Like Peptide-1 Receptor",
- "Absorptiometry, Photon",
- "Randomized Controlled Trials as Topic",
- "Body Composition",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Antihypertensive Agents",
+ "Hypertension",
+ "Blood Pressure",
+ "Treatment Outcome",
"Diabetes Mellitus, Type 2",
- "Bayes Theorem",
- "Female",
- "Hypoglycemic Agents",
- "Male",
- "Middle Aged"
- ]
+ "Risk Factors",
+ "Animals",
+ "Sodium-Glucose Transporter 2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "21"
+ }
},
{
- "PMID": "39710722",
- "Title": "European journal of medical research",
- "ArticleTitle": "Differential seasonal performance of C3-epi-D3 level and proportion on multiple metabolic disorders in patients with type 2 diabetes mellitus.",
- "Abstract": "Our study releases a seasonally differential impact of C3-epi-D3 levels and proportions on metabolic disorders of T2DM patients, considering to be potentially related to their pathogenesis of different metabolic disorders. The independent association between %C3-epi-D3 and CKD suggests a potential pathological relevance involving C3-epi-D3 itself.",
+ "PMID": "39302589",
+ "Title": "Current cardiology reports",
+ "ArticleTitle": "Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention.",
+ "Abstract": "The present review aims to summarize current evidence, explore underlying mechanisms, and help guide clinicians regarding statin therapy and diabetes risk in primary prevention.The observational and genetic epidemiology, as well as evidence from randomized controlled trials and meta-analyses, illustrate a modest, dose-dependent increase in risk of diabetes from statin therapy. Risk of new onset diabetes from statins appears to be greatest in those near the diagnostic threshold for diabetes or with diabetes risk factors prior to statin initiation. The risk of incident diabetes is vastly offset by the cardiovascular protection offered from statin therapy and should not deter guideline recommended statin initiation in primary prevention.",
"Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Primary Prevention",
+ "Incidence",
+ "Cardiovascular Diseases",
"Diabetes Mellitus, Type 2",
- "Female",
- "Male",
- "Middle Aged",
- "Seasons",
- "Aged",
- "Metabolic Diseases",
- "Calcifediol",
- "Prospective Studies",
- "Adult",
- "Renal Insufficiency, Chronic",
- "Biomarkers"
- ]
+ "Risk Factors",
+ "Diabetes Mellitus",
+ "Randomized Controlled Trials as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "20"
+ }
},
{
- "PMID": "39710638",
- "Title": "BMC ophthalmology",
- "ArticleTitle": "Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study.",
- "Abstract": "The risk of young and middle-aged patients with increased as a result of certain patient characteristics and complications, especially lower dietary compliance and physical activity level.",
+ "PMID": "39176664",
+ "Title": "Studies in health technology and informatics",
+ "ArticleTitle": "Identifying Patterns in Long Term CGM and Insulin Data - An Explorative Study.",
+ "Abstract": "The increased utilization of continuous glucose monitors (CGM) and smart insulin pens (SIP) among people with type 2 diabetes generates significant health data. This study explored possible patterns in long term CGM and SIP data.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
+ "Blood Glucose Self-Monitoring",
"Humans",
- "Diabetic Retinopathy",
- "Risk Factors",
- "Male",
- "Female",
- "Retrospective Studies",
- "Middle Aged",
- "Adult",
- "Young Adult",
"Diabetes Mellitus, Type 2",
- "China"
- ]
+ "Insulin",
+ "Insulin Infusion Systems",
+ "Blood Glucose",
+ "Hypoglycemic Agents"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39710070",
- "Title": "Diabetes research and clinical practice",
- "ArticleTitle": "Health disparities in diabetes treatment: The challenge of G6PD deficiency.",
- "Abstract": "This research highlights serious gaps in the management of G6PD-deficient patients with diabetes, who suffer from insufficient medication management and higher rates of complications. These findings underscore the need to account for G6PD deficiency in diabetes treatment to ensure equitable and effective healthcare for this vulnerable population.",
+ "PMID": "39176547",
+ "Title": "Studies in health technology and informatics",
+ "ArticleTitle": "Development of a Basal Insulin Titration System to Support Healthcare Providers in Treatment of People with Type 2 Diabetes: Preliminary Results.",
+ "Abstract": "The study aims to develop a system for insulin titration in type 2 diabetes to assist primary healthcare providers. Usability testing with end-users is ongoing.",
"Predictions": [
- "Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
+ "Diabetes Mellitus, Type 2",
"Humans",
- "Glucosephosphate Dehydrogenase Deficiency",
- "Female",
- "Male",
- "Middle Aged",
- "Glycated Hemoglobin",
+ "Insulin",
"Hypoglycemic Agents",
- "Adult",
- "Aged",
- "Blood Glucose",
- "Cohort Studies",
- "Healthcare Disparities",
- "Diabetes Complications",
- "Diabetes Mellitus",
- "Diabetes Mellitus, Type 2"
- ]
+ "Drug Therapy, Computer-Assisted"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "23"
+ }
},
{
- "PMID": "39710013",
- "Title": "Annals of epidemiology",
- "ArticleTitle": "Gut microbiome and obesity in late adolescence: A case-control study in \"Children of 1997\" birth cohort.",
- "Abstract": "Adolescents with obesity had a distinct gut microbiota profile compared to the controls, possibly linked to metabolic pertubation and related diseases.",
+ "PMID": "39127032",
+ "Title": "Med (New York, N.Y.)",
+ "ArticleTitle": "Therapy for HFpEF: A step forward brings new hope for people with obesity and diabetes.",
+ "Abstract": "The STEP-HFpEF DM trial showed that semaglutide improved body weight, systemic inflammation, and heart failure symptoms in people with obesity-related heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes. By addressing both metabolic and cardiovascular risk, semaglutide is a promising therapeutic option for HFpEF in addition to SGLT2i.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Gastrointestinal Microbiome",
- "Case-Control Studies",
- "Female",
- "Male",
- "Adolescent",
- "Pediatric Obesity",
- "Feces",
+ "Obesity",
"Diabetes Mellitus, Type 2",
- "Birth Cohort",
- "Bacteroides"
- ]
+ "Heart Failure",
+ "Stroke Volume",
+ "Glucagon-Like Peptides",
+ "Sodium-Glucose Transporter 2 Inhibitors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "11"
+ }
},
{
- "PMID": "39710002",
- "Title": "Metabolism: clinical and experimental",
- "ArticleTitle": "Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.",
- "Abstract": "Our findings highlight the common genetic underpinnings between type 2 diabetes and muscle loss and frailty and inform drug targets with pleiotropic effects on both of these aging-related challenges.",
+ "PMID": "39127031",
+ "Title": "Med (New York, N.Y.)",
+ "ArticleTitle": "Glucagon-like peptide receptor-1 receptor agonists: The emerging fourth pillar in type 2 diabetes and chronic kidney disease?",
+ "Abstract": "Previously, no randomized controlled trials investigated the renoprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) as the primary endpoint in patients with diabetes and chronic kidney disease. In the FLOW trial, Perkovic et\u00a0al. showed that once-weekly semaglutide reduced kidney failure, kidney-related death, and cardiovascular death by 24% as compared with placebo in patients with type 2 diabetes at high risk of renal progression..",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
- "Genome-Wide Association Study",
- "Frailty",
- "Genetic Pleiotropy",
- "Muscle, Skeletal",
- "Comorbidity",
- "Polymorphism, Single Nucleotide",
- "Female",
- "Male",
- "Phenotype",
- "Aged",
- "Genetic Predisposition to Disease"
- ]
+ "Renal Insufficiency, Chronic",
+ "Glucagon-Like Peptides",
+ "Hypoglycemic Agents",
+ "Diabetic Nephropathies",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "11"
+ }
},
{
- "PMID": "39709941",
- "Title": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
- "ArticleTitle": "Positive impact of DPP-4 or SGLT2 inhibitors on mild cognitive impairment in type 2 diabetes patients on metformin therapy: A metabolomic mechanistic insight.",
- "Abstract": "Mild cognitive impairment is increasingly recognized as a complication of type 2 diabetes (T2D). Although currently no disease-modifying treatments for cognitive disorders exist, interest surged in potential neuroprotective effects of newer anti-diabetic drugs. This study investigates the impact of newer anti-diabetic drug classes, dipeptidyl peptidase-4 (DPP-4i) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) - on cognitive decline in T2D patients on metformin therapy. A prospective observational cohort study was conducted, with a follow-up duration of 6 months. The study compared the cognitive performance of T2D patients on metformin monotherapy to those on a combination of metformin with DPP-4i or SGLT2i, using the Montreal Cognitive Assessment Battery. A group of healthy volunteers served as a reference. At baseline, patients receiving combination therapy had a cognitive performance comparable to that of healthy volunteers, while those on metformin monotherapy scored lower. These differences persisted for patients who completed the follow-up, though there was no change within group. Baseline differences were independent of glycemic control, blood lipids, renal function, and serum inflammatory markers. Comprehensive metabolomics and lipidomics revealed that T2D patients on metformin monotherapy exhibited enriched purine, glutathione and sphingolipid metabolism, with alterations in xanthine, L-pyroglutamic acid, and several sphingomyelins. These changes suggest increased oxidative stress in T2D, mitigated in the combination therapy group, as evidenced by total serum antioxidant capacity. As such, we conclude that the combination of DPP-4i or SGLT2i with metformin positively impacts cognitive function in T2D patients by modulating metabolic pathways rather than improving glycemic control, peripheral diabetic complications, or systemic inflammation.",
+ "PMID": "39111552",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "The incidence of acute pancreatitis with GLP-1 receptor agonist therapy in individuals with a known history of pancreatitis.",
+ "Abstract": "Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been reported to increase the risk of acute pancreatitis (AP). This real-world study did not observe a higher frequency of AP with GLP-1RA exposure in adults with T2D and a prior history of AP regardless of etiology.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Aged",
- "Female",
"Humans",
+ "Pancreatitis",
"Male",
+ "Female",
"Middle Aged",
- "Cognition",
- "Cognitive Dysfunction",
+ "Incidence",
"Diabetes Mellitus, Type 2",
- "Dipeptidyl-Peptidase IV Inhibitors",
- "Drug Therapy, Combination",
+ "Aged",
"Hypoglycemic Agents",
- "Metabolomics",
- "Metformin",
- "Prospective Studies",
- "Sodium-Glucose Transporter 2 Inhibitors"
- ]
+ "Acute Disease",
+ "Adult",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "8"
+ }
},
{
- "PMID": "39709924",
- "Title": "Food chemistry",
- "ArticleTitle": "Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice.",
- "Abstract": "Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, known for its anti-inflammatory and antioxidant properties. However, no studies have investigated on the ability of SFE to prevent or treat DN. This study established a high-fat diet combined with a streptozotocin-induced type II diabetes mellitus mouse model. We administered SFE treatment to examine its protective effects on renal and intestinal homeostasis in DN mice. After 4\u00a0weeks of treatment, SFE (50\u00a0mg/kg b.w.) not only reduced blood glucose concentration (20.3\u00a0%, P\u00a0<\u00a00.001), kidney to body weight ratio (26.2\u00a0%, P\u00a0<\u00a00.01), and levels of serum total cholesterol (40.6\u00a0%, P\u00a0<\u00a00.001), triglycerides (38.2\u00a0%, P\u00a0<\u00a00.01), creatinine (36.7\u00a0%, P\u00a0<\u00a00.01), and urea nitrogen (45.0\u00a0%, P\u00a0<\u00a00.001) in DN mice compared to control mice but also increased the kidney superoxide dismutase (72.7\u00a0%, P\u00a0<\u00a00.001), catalase (51.1\u00a0%, P\u00a0<\u00a00.001), and glutathione peroxidase activities (31.6\u00a0%, P\u00a0<\u00a00.01), as well as glutathione levels (39.2\u00a0%, P\u00a0<\u00a00.01) in comparison to DN mice. Furthermore, SFE decreased levels of reactive oxygen species (55.4\u00a0%, P\u00a0<\u00a00.01), 4-hydroxyalkenals (36.9\u00a0%, P\u00a0<\u00a00.001), malondialdehyde (42.6\u00a0%, P\u00a0<\u00a00.001), and 8-hydroxy-deoxyguanosine (26.3\u00a0%, P\u00a0<\u00a00.001), accompanied by a meliorating kidney morphological abnormalities. Notably, a reduction in renal inflammatory factors was also observed in SFE-treated DN mice compared to untreated DN mice, particularly in the C-X-C motif chemokine ligand 8 factors (54.8\u00a0%, P\u00a0<\u00a00.001). Western blotting results indicated that SFE significantly down-regulated the protein expression of TLR4 and MyD88 (1.9, 1.7-fold, P\u00a0<\u00a00.001). Additionally, SFE improved gut microbiota (GM) dysbiosis and intestinal homeostasis, as evidenced by increased expression of antimicrobial peptides and tight junction proteins in colon tissue. SFE appeared to enhance the proliferation of probiotics, such as Bacteroidota, Lachnospiraceae_NK4A136_group and norank_f__Muribaculaceae, while also decreasing harmful bacteria to a greater extent compared to STZ treatment. These findings suggest that SFE modulates GM and improves intestinal homeostasis, providing a theoretical basis for its use in the treatment of DN.",
+ "PMID": "39084811",
+ "Title": "Endocrinology and metabolism clinics of North America",
+ "ArticleTitle": "Diagnosis and Treatment of Hyperglycemia in Pregnancy: Type 2 Diabetes Mellitus and Gestational Diabetes.",
+ "Abstract": "Hyperglycemia in pregnancy due to pre-existing Type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) is rising globally with increasing rates of risk factors for metabolic disease. This review summarizes current evidence and recommendations from national and international guidelines for diagnosis and management of T2DM and GDM to optimize maternal and neonatal outcomes.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
- "Animals",
- "Mice",
- "Diet, High-Fat",
- "Male",
- "Kidney",
- "Diabetic Nephropathies",
- "Gastrointestinal Microbiome",
- "Dysbiosis",
- "Isothiocyanates",
"Humans",
- "Mice, Inbred C57BL",
- "Protective Agents",
- "Blood Glucose",
- "Streptozocin",
- "Sulfoxides",
+ "Pregnancy",
+ "Diabetes, Gestational",
"Diabetes Mellitus, Type 2",
- "Raphanus",
- "Oxidative Stress",
- "Bacteria",
- "Superoxide Dismutase"
- ]
+ "Female",
+ "Hyperglycemia",
+ "Hypoglycemic Agents",
+ "Pregnancy in Diabetics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "1"
+ }
},
{
- "PMID": "39709670",
- "Title": "European journal of cancer (Oxford, England : 1990)",
- "ArticleTitle": "Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors.",
- "Abstract": "GLP1a use in cancer patients with T2DM receiving ICIs was associated with reduced MACE and all-cause mortality without an increased risk in serious adverse events.",
+ "PMID": "39069090",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Determining the 1-hour post-load glucose which identifies diabetes in Africans: Insight from the Africans in America study.",
+ "Abstract": "Diagnosing diabetes by shortening the OGTT to 1-h and substituting 1-h post-load glucose (PG)\u00a0\u2265\u00a0209\u00a0mg/dL for 2-h PG\u2265200\u00a0mg/dL has been proposed. One-hour PG\u2265209\u00a0mg/dL is from a meta-analysis without any African-descent populations. Our data suggest 1-h PG\u2265183\u00a0mg/dL maybe more optimal for Africans. As with waist circumference guidelines, population-specific thresholds may be appropriate.",
"Predictions": [
- "Cancer",
- "Cardiovascular diseases",
+ "Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Male",
+ "Blood Glucose",
+ "Glucose Tolerance Test",
"Female",
- "Immune Checkpoint Inhibitors",
- "Retrospective Studies",
- "Neoplasms",
- "Aged",
+ "Male",
+ "Black People",
"Middle Aged",
- "Cardiovascular Diseases",
- "Glucagon-Like Peptide 1",
- "Diabetes Mellitus, Type 2"
- ]
+ "Diabetes Mellitus",
+ "Adult",
+ "Diabetes Mellitus, Type 2",
+ "United States",
+ "African People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "29"
+ }
},
{
- "PMID": "39709519",
- "Title": "Medical science monitor : international medical journal of experimental and clinical research",
- "ArticleTitle": "MicroRNAs as Biomarkers for Metabolic Disorders in Polycystic Ovary Syndrome (PCOS): A Review.",
- "Abstract": "Polycystic ovary syndrome (PCOS) is associated with several mild metabolic disorders, including insulin resistance (IR), obesity, and dyslipidemia, as well as with some more severe ones, including type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. Clinically, mild metabolic complications of PCOS such as IR or lipid metabolism disorders are the predictors of these more severe ones. So far, there is no reliable single marker that enables defining metabolic risk in patients with PCOS. Therefore, novel independent markers of metabolic disturbances are needed. Most reports have focused on microRNA (miRNA, miR) assessment in blood serum or granulosa cells, suggesting the high potential clinical utility of such management. The greatest number of studies focused on the association between miRNAs and IR, obesity, or lipid disorders, and some miRNAs were characteristics of all these processes concomitantly. The altered expression of miR-222, miR-223, miR-320, and miR-122 has been most commonly mentioned as the regulator of these metabolic distortions and seems to result from common regulation pathways of metabolic disturbances. In turn, the current literature lacked the miRNA which could be identified as a reliable marker of type 2 diabetes mellitus or NAFLD accompanying PCOS. Therefore, the main objective of future studies should be determining miRNA markers of these most serious metabolic complications. This article aims to review the role of microRNAs as biomarkers for metabolic disorders in PCOS.",
+ "PMID": "39028078",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "The KgA1c Paradox: Widening the spectrum.",
+ "Abstract": "The term KgA1c paradox is used to describe the unwanted rise in weight that occurs when HbA1c is controlled using conventional therapy. We highlight facets of pathophysiology, prevention, pharmacology, person centred care, and epidemiology, which correspond to the concept of KgA1c paradox. We suggest a novel index, KgA1c product [(BMI) x (HbA1c)], which can be used to evaluate efficacy of drugs, and assess metabolic control in persons with diabetes.",
"Predictions": [
+ "Diabetes",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "Polycystic Ovary Syndrome",
- "Female",
- "MicroRNAs",
- "Biomarkers",
- "Metabolic Diseases",
- "Insulin Resistance",
- "Non-alcoholic Fatty Liver Disease",
+ "Glycated Hemoglobin",
+ "Hypoglycemic Agents",
+ "Body Mass Index",
"Diabetes Mellitus, Type 2",
- "Obesity"
- ]
+ "Weight Gain",
+ "Diabetes Mellitus"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "19"
+ }
},
{
- "PMID": "39709437",
- "Title": "Cardiovascular diabetology",
- "ArticleTitle": "Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation.",
- "Abstract": "A high level potassium intake estimated from urine potassium excretion was independently associated with a low risk of MACE in patients with type 2 diabetes. Increasing potassium intake may be a potential effective strategy for cardiovascular risk reduction beyond controlling traditional risk factors.",
+ "PMID": "38988282",
+ "Title": "Journal of diabetes investigation",
+ "ArticleTitle": "A consensus statement from the Japan Diabetes Society: A proposed algorithm for pharmacotherapy in people with type\u20092 diabetes - 2nd edition (English version).",
+ "Abstract": "This algorithm was issued for the appropriate use of drugs for the treatment of type\u20092 diabetes mellitus in Japan. The revisions include safety considerations, fatty liver disease as a comorbidity to be taken into account and the position of tirzepatide.",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
"Diabetes Mellitus, Type 2",
+ "Algorithms",
+ "Japan",
+ "Hypoglycemic Agents",
+ "Consensus",
+ "Societies, Medical"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "38971377",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Sex differences in the plasma glucagon responses to a high carbohydrate meal and a glucose drink in type 2 diabetes.",
+ "Abstract": "Elevated fasting glucagon concentrations and/or attenuated postprandial glucagon suppression are characteristics of type 2 diabetes (T2D) and contribute to hyperglycaemia. This study shows that hyperglucagonaemia is more prominent in males than females after a nutrient load in T2D, adding insights into sex differences in relation to the pathophysiology of T2D.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon",
"Female",
"Male",
- "Prospective Studies",
"Middle Aged",
- "Risk Assessment",
+ "Glucose",
+ "Dietary Carbohydrates",
+ "Postprandial Period",
+ "Blood Glucose",
+ "Sex Characteristics",
"Aged",
- "Time Factors",
- "Potassium, Dietary",
- "Cardiovascular Diseases",
- "Reproducibility of Results",
- "Prognosis",
- "Biomarkers",
- "Risk Factors",
- "Protective Factors",
- "Albuminuria",
- "Urinalysis",
- "Recommended Dietary Allowances"
- ]
+ "Sex Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "7"
+ }
},
{
- "PMID": "39709342",
- "Title": "BMC geriatrics",
- "ArticleTitle": "A correlation study between blood glucose fluctuation and chronic pain in the older people with type 2 diabetes mellitus.",
- "Abstract": "ChiCTR1800019107.",
+ "PMID": "38950981",
+ "Title": "Cleveland Clinic journal of medicine",
+ "ArticleTitle": "SGLT-2 inhibitors in heart failure and chronic kidney disease: A review for internists.",
+ "Abstract": "Despite current therapies, heart failure and chronic kidney disease continue to be major causes of morbidity and mortality. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have recently become standard-of-care therapy for these conditions. This review summarizes important randomized controlled trials of SGLT-2 inhibitors and guidelines for using these agents in patients with heart failure and chronic kidney disease in both clinic and hospital settings.",
"Predictions": [
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Heart Failure",
+ "Renal Insufficiency, Chronic",
"Diabetes Mellitus, Type 2",
- "Male",
- "Female",
- "Aged",
- "Blood Glucose",
- "Chronic Pain",
- "Middle Aged",
- "Pain Measurement",
- "Aged, 80 and over"
- ]
+ "Randomized Controlled Trials as Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "2"
+ }
},
{
- "PMID": "39708996",
- "Title": "Preventive medicine",
- "ArticleTitle": "Association between physical activity-related metabolic signature and cardiometabolic diseases and multimorbidity: A cohort study from UK biobank.",
- "Abstract": "Physical activity-related metabolic signature is linked to reduced risks of CMDs and CMM. We once again emphasize the importance of physical activity for CMDs prevention from a metabolic perspective, especially for individuals at high genetic risk.",
+ "PMID": "38926031",
+ "Title": "Trends in molecular medicine",
+ "ArticleTitle": "3-O-acylated bile acids: disrupters or harmonizers of metabolism?",
+ "Abstract": "Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).",
"Predictions": [
- "Cardiovascular diseases",
"Diabetes type 2"
],
"MeshTerms": [
"Humans",
- "United Kingdom",
- "Female",
+ "Bile Acids and Salts",
+ "Animals",
+ "Gastrointestinal Microbiome",
+ "Acylation",
+ "Diabetes Mellitus, Type 2",
+ "Bacteroides"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "38922299",
+ "Title": "Emerging microbes & infections",
+ "ArticleTitle": "Early neurosyphilis with serofast state.",
+ "Abstract": "We report a rare case of confirmed early neurosyphilis with serofast state in HIV-negative patient, with uncontrolled type 2 diabetes mellitus. Syphilitic meningitis was diagnosed initially on serology and cerebrospinal fluid (CSF) analysis. The patient had persistently raised non-treponemal titres on serum with negative CSF venereal disease research laboratory result, following treatment during 3 years of follow-up.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neurosyphilis",
"Male",
- "Exercise",
+ "Treponema pallidum",
+ "Diabetes Mellitus, Type 2",
+ "Anti-Bacterial Agents",
"Middle Aged",
- "Prospective Studies",
- "Multimorbidity",
+ "Antibodies, Bacterial"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "38897878",
+ "Title": "Trends in endocrinology and metabolism: TEM",
+ "ArticleTitle": "Food perception induces fast fragmentation of hepatic mitochondria.",
+ "Abstract": "Henschke et al. have recently shown that sensory food perception in mice integrated at the hypothalamus would be sufficient to suppress hepatic glucose production in a rapid mechanism involving a newly described AKT-dependent kinase pathway that engages mitochondrial fission dynamics. Exploiting this pathway could guide strategies to treat type 2 diabetes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Mitochondrial Dynamics",
+ "Mice",
+ "Mitochondria, Liver",
"Diabetes Mellitus, Type 2",
+ "Food",
+ "Liver"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "20"
+ }
+ },
+ {
+ "PMID": "38889536",
+ "Title": "Journal of diabetes and its complications",
+ "ArticleTitle": "Achievement of normoglycemia with tirzepatide in type 2 diabetes mellitus: A step closer to drug-induced diabetes remission?",
+ "Abstract": "We sought to determine whether treatment with tirzepatide in type 2 diabetes mellitus (T2DM) patients can increase the odds for achieving normoglycemia, compatible with glycated hemoglobin levels lower than 5.7\u00a0%. We demonstrated that treatment with tirzepatide versus control increased the odds for achievement of normoglycemia by >16 times.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 2",
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Hypoglycemic Agents",
+ "Glycated Hemoglobin",
"Aged",
- "Cardiovascular Diseases",
- "Biological Specimen Banks",
- "Coronary Disease",
- "Genetic Predisposition to Disease",
- "Stroke",
- "Adult",
- "UK Biobank"
- ]
+ "Remission Induction",
+ "Blood Glucose",
+ "Treatment Outcome",
+ "Glycemic Control",
+ "Glucagon-Like Peptide-2 Receptor",
+ "Gastric Inhibitory Polypeptide",
+ "Tirzepatide"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "19"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/mental_health.json b/testModel/dataset/mental_health.json
index 6607c9800..7c1755650 100644
--- a/testModel/dataset/mental_health.json
+++ b/testModel/dataset/mental_health.json
@@ -3,7 +3,7 @@
"PMID": "39738254",
"Title": "Scientific reports",
"ArticleTitle": "Cross sectional associations of physical activity and sleep with mental health among Chinese university students.",
- "Abstract": "The intensity of PA among university students is predominantly light, and the reported rate of insufficient sleep is relatively high. Moderate to high-intensity PA and sufficient high-quality sleep may alleviate MH issues among college students, with an interaction effect observed among PA, sleep, and depression symptoms. Future studies should further explore targeted interventions combining PA and sleep behaviors to enhance the MH of university students.",
+ "Abstract": "This study aimed to examine the levels of physical activity (PA), sleep, and mental health (MH), specifically depression, anxiety, and stress, among Chinese university students. It also aimed to analyze the influencing factors of MH, providing a theoretical foundation for developing intervention programs to improve college students' mental health.A stratified, clustered, and phased sampling method was employed. In September 2022, a survey was conducted among 36,756 university students from 104 higher education institutions across 31 provinces, autonomous regions, and municipalities in China. The participants' PA behaviors, sleep patterns, depressive symptoms (use the CES-D), anxiety symptoms (use the GAD-7), smoking and drinking behaviors, and demographic information were assessed through an online questionnaire using Questionnaire Star software.A total of 30,475 valid questionnaires were completed. The proportion of university students engaging in light-intensity PA was 77.6%. The prevalence of insufficient sleep was 39.5%, whereas the prevalence of poor sleep quality was 16.7%. The prevalence of depressive symptoms was 10%, and the prevalence of anxiety symptoms was 23.3%. Binary logistic regression analysis revealed that engaging in moderate to high-intensity PA and having sufficient and high-quality sleep were associated with a lower likelihood of depressive symptoms (OR\u2009=\u20090.207-0.800, P\u2009<\u20090.01), whereas appropriate sleep duration and higher sleep quality were associated with a lower likelihood of anxiety symptoms (OR\u2009=\u20090.134-0.827, P\u2009<\u20090.001).The intensity of PA among university students is predominantly light, and the reported rate of insufficient sleep is relatively high. Moderate to high-intensity PA and sufficient high-quality sleep may alleviate MH issues among college students, with an interaction effect observed among PA, sleep, and depression symptoms. Future studies should further explore targeted interventions combining PA and sleep behaviors to enhance the MH of university students.",
"Predictions": [
"Mental Health"
],
@@ -26,13 +26,18 @@
"Adolescent",
"Sleep Quality",
"Prevalence"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39737457",
"Title": "Frontiers in public health",
"ArticleTitle": "Impact of COVID-19 vaccination on adolescent and youth students' mental health and bullying behaviors after the lifting of COVID-19 restrictions in China.",
- "Abstract": "This study suggests that COVID-19 vaccination will not only protect students' physical health, but also improve mental health. It is crucial to explore the mechanism between vaccination and mental health problems and bullying behaviors in further studies.",
+ "Abstract": "Vaccination plays an important role in fighting against COVID-19. However, it is unclear about the association among vaccination, mental health, and bullying behaviors in China.This online survey was conducted to investigate the association among vaccination status, mental health problems and bullying behaviors in students from December 14, 2022 to February 28, 2023 in Sichuan, China. All participants (\u202f=\u202f82,873) were adolescents recruited via their teachers and professors. Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), PTSD Checklist for DSM-5 (PCL-5), Sleep Severity Index Scale (ISI) and Cyberbullying behaviors were tested.The rates of depression, anxiety and PTSD in participants without vaccination were significantly higher than that in those with vaccination. Moreover, participants with more doses of vaccines had significantly lower rates of depression, anxiety, PTSD, school and cyber bullying (\u202f<\u202f0.001). The rates of homosexual orientation, drinking, smoking were higher in participants with three or more doses of vaccines than those with less doses of vaccines (\u202f<\u202f0.001).This study suggests that COVID-19 vaccination will not only protect students' physical health, but also improve mental health. It is crucial to explore the mechanism between vaccination and mental health problems and bullying behaviors in further studies.",
"Predictions": [
"Mental Health"
],
@@ -53,13 +58,18 @@
"Anxiety",
"SARS-CoV-2",
"Stress Disorders, Post-Traumatic"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
},
{
"PMID": "39735766",
"Title": "Frontiers in public health",
"ArticleTitle": "Unemployment and mental health: a global study of unemployment's influence on diverse mental disorders.",
- "Abstract": "These findings underscore the critical interplay between socio-economic factors and mental health, highlighting the need for proactive strategies to address the dual burden of unemployment and mental health disorders. Targeted interventions, such as employment support programs and accessible mental health services, are essential to improve global mental health outcomes. These initiatives can also alleviate the economic burden of unemployment by boosting workforce participation and productivity. Long-term economic gains may offset the increased healthcare expenditures associated with mental health support.",
+ "Abstract": "Globally, one in five individuals faces unemployment, which substantially increases their risk of developing mental disorders. Understanding the relationship between unemployment and specific mental health outcomes is crucial for formulating effective policy interventions.This study examines the relationship between unemployment and mental disorders across 201 countries from 1970 to 2020. Using a fixed-effects model, we analyze the impact of unemployment on various mental health outcomes, including anxiety, depression, bipolar disorder, drug use, and eating disorders, with a focus on demographic variations.The analysis reveals a significant positive association between unemployment and mental disorders, particularly anxiety, depression, and bipolar disorder. Moreover, distinct patterns emerge, linking unemployment to higher rates of drug use and eating disorders in specific demographics.These findings underscore the critical interplay between socio-economic factors and mental health, highlighting the need for proactive strategies to address the dual burden of unemployment and mental health disorders. Targeted interventions, such as employment support programs and accessible mental health services, are essential to improve global mental health outcomes. These initiatives can also alleviate the economic burden of unemployment by boosting workforce participation and productivity. Long-term economic gains may offset the increased healthcare expenditures associated with mental health support.",
"Predictions": [
"Mental Health"
],
@@ -75,7 +85,12 @@
"Mental Health",
"Young Adult",
"Socioeconomic Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735765",
@@ -99,13 +114,18 @@
"Middle East",
"Mental Health",
"Public Opinion"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735755",
"Title": "Frontiers in public health",
"ArticleTitle": "A study of the impact of internet use on the mental health of rural older adults-empirical analysis based on China General Social Survey 2021 data.",
- "Abstract": "Internet use, social participation, and friend-gathering type participation all have an effect on the mental health of rural older adults. The research results reveal the impact of Internet use on the mental health of rural older adults and its mechanism, which is helpful to provide useful enlightenment for improving the mental health of rural older adults in the Internet era.",
+ "Abstract": "In the context of the era of both digitalization and aging, Internet use plays an important role in supporting the rural older adults to actively integrate into the digital society and improve their mental health.To explore the impact of Internet use on the mental health of rural older adults and the mediating role of their social participation.Based on the latest data from the China General Social Survey (CGSS) 2021, the study utilized linear regression analysis to explore the impact of Internet use on the mental health of rural older adults and the mediating role of their social participation.The two important results of the analysis are: (1) internet use is significantly and positively related to the mental health of rural older adults, and (2) internet use can have an indirect effect on the mental health of rural older adults through two pathways: (a) the complete mediating effect of social participation;(b) partial mediating role of friend-gathering type participation.Internet use, social participation, and friend-gathering type participation all have an effect on the mental health of rural older adults. The research results reveal the impact of Internet use on the mental health of rural older adults and its mechanism, which is helpful to provide useful enlightenment for improving the mental health of rural older adults in the Internet era.",
"Predictions": [
"Mental Health"
],
@@ -123,13 +143,18 @@
"Middle Aged",
"Aged, 80 and over",
"Internet"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735753",
"Title": "Frontiers in public health",
"ArticleTitle": "Chronic impacts of natural infrastructure on the physical and psychological health of university students during and after COVID-19: a case study of Chengdu, China.",
- "Abstract": "The study emphasizes the importance of incorporating natural elements into urban planning to enhance outdoor activity and well-being, especially in post-pandemic settings. Recommendations are provided for future urban design to address the therapeutic needs of specific populations.",
+ "Abstract": "The COVID-19 pandemic has underscored the health benefits of green spaces, yet research on how specific elements of natural infrastructure affect well-being during the pandemic has been limited.This study, conducted at Sichuan Agricultural University with 300 students in 2022, investigated how urban natural infrastructure impacts physical and psychological well-being during the pandemic. Different aspects of natural infrastructure, such as thermal comfort, air quality (negative ion concentration), and noise and light levels, varied in their positive effects on students' health.The findings revealed that 65.6% of university students felt reduced stress when engaging with outdoor spaces, and 72.8% of them renewed recognized the therapeutic value of nature.The study emphasizes the importance of incorporating natural elements into urban planning to enhance outdoor activity and well-being, especially in post-pandemic settings. Recommendations are provided for future urban design to address the therapeutic needs of specific populations.",
"Predictions": [
"Mental Health"
],
@@ -146,13 +171,18 @@
"Adult",
"SARS-CoV-2",
"City Planning"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735752",
"Title": "Frontiers in public health",
"ArticleTitle": "Effects of a flexibly delivered group-based acceptance and commitment therapy on reducing stress and enhancing psychological wellbeing in parents of school-age children during the COVID-19 pandemic: a quasi-experimental study.",
- "Abstract": "The findings highlight the potential of group-based Acceptance and Commitment Therapy to alleviate stress and improve psychological well-being in parents of school-age children, regardless of the delivery method, especially during crises such as the COVID-19 pandemic. However, due to limitations in the study design, caution is warranted when interpreting the overall effects of group-based ACT on parent outcomes and the moderating role of delivery methods. Further research is needed to validate these findings and explore the nuances of delivery methods in similar real-world situations.",
+ "Abstract": "COVID-19 has increased parental stress and significantly impacted the psychological well-being of individuals, especially parents of school-age children. Acceptance and Commitment Therapy posits that individuals can accept their unchangeable inner experiences (thoughts and feelings) while acting in ways aligned with their personal values, demonstrating effectiveness in reducing stress and improving psychological well-being, especially among parents of children with chronic illness. This study aimed to test the effectiveness of a group-based ACT, delivered flexibly, in improving stress and psychological well-being in parents with school-age children, regardless of their children's chronic conditions, within a real-world context.This quasi-experimental study recruited parents with school-age children, through convenience sampling from the Christian Family Service Centre in Hong Kong. The group-based Acceptance and Commitment Therapy intervention consisted of five weekly sessions delivered via face-to-face meetings and online videoconferencing, consistent with participants' preferences and COVID-19 related restrictions in Hong Kong. Paired t-tests and Generalized Estimating Equations following the intention-to-treat principle were used to examine the overall effects and the moderating effects of delivery methods.The study included 250 parents, with an average age of 40.90 years, mostly women. The average age of their youngest child was 7.68 years. In line with COVID-19-related restrictions and participants' preferences, 109 parents participated in online sessions, while 141 attended face-to-face sessions. Results showed significant small-to-medium improvements in various outcome variables after the intervention, including parental stress (Cohen's \u202f=\u202f0.26), general stress (\u202f=\u202f0.18), depressive symptoms (\u202f=\u202f0.18), mental health literacy (\u202f=\u202f0.43), subjective wellbeing (\u202f=\u202f0.25), and psychological flexibility (\u202f=\u202f0.28). Notably, the online videoconferencing format was found to be as effective as the face-to-face format, with similar session attendance rates.The findings highlight the potential of group-based Acceptance and Commitment Therapy to alleviate stress and improve psychological well-being in parents of school-age children, regardless of the delivery method, especially during crises such as the COVID-19 pandemic. However, due to limitations in the study design, caution is warranted when interpreting the overall effects of group-based ACT on parent outcomes and the moderating role of delivery methods. Further research is needed to validate these findings and explore the nuances of delivery methods in similar real-world situations.",
"Predictions": [
"Mental Health"
],
@@ -172,13 +202,18 @@
"Psychotherapy, Group",
"Pandemics",
"Mental Health"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735743",
"Title": "Frontiers in public health",
"ArticleTitle": "The impact of university freshmen's mental health on academic performance: an empirical study based on M University in Fujian Province, China.",
- "Abstract": "University officials should strengthen mental health surveillance and intervention during the first few years of student enrollment to mitigate the harmful impact of mental health issues on academic performance. The moderate to strong effect sizes for variables like somatization, depression, and anxiety indicate that early interventions could be crucial in reducing their negative impact on both short-and long-term academic outcomes. Furthermore, the study discovered disparities in mental health and academic performance across students of different genders and enrollment years, emphasizing that educational personnel should design more tailored mental health support methods that consider these differences.",
+ "Abstract": "To investigate the impact of freshmen's mental health on their short-and long-term academic performance, as well as to provide empirical evidence for improving university students' mental health intervention tactics and higher education quality.A multiple regression model was used to analyze student data from 3\u202fyears of enrollment at M University in Fujian Province.Different mental health problems have a significant impact on academic performance, which varies by gender, enrollment year, and subject. Somatization, anxiety, and depression have a significant negative impact on both comprehensive and single-subject scores, while anxiety, social aggression, and other variables can increase academic performance in certain settings. Some effects are notably moderated by gender and enrollment year.University officials should strengthen mental health surveillance and intervention during the first few years of student enrollment to mitigate the harmful impact of mental health issues on academic performance. The moderate to strong effect sizes for variables like somatization, depression, and anxiety indicate that early interventions could be crucial in reducing their negative impact on both short-and long-term academic outcomes. Furthermore, the study discovered disparities in mental health and academic performance across students of different genders and enrollment years, emphasizing that educational personnel should design more tailored mental health support methods that consider these differences.",
"Predictions": [
"Mental Health"
],
@@ -196,13 +231,18 @@
"Anxiety",
"Adolescent",
"Adult"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39735742",
"Title": "Frontiers in public health",
"ArticleTitle": "Effects of volcanic eruptions on the mental health of exposed populations: a systematic review.",
- "Abstract": "The negative influence of experiencing volcanic activity on mental health was confirmed. Clearly, there is a need for more research to improve the mental health of the populations highly exposed to volcanic eruptions. Recommendations for future research are also included.",
+ "Abstract": "Millions of people living in volcanic environments are at risk of experiencing volcanic eruptions, a natural disaster. This systematic review aimed to collect empirical evidence of the effects of volcanic eruptions on the mental health of the exposed populations.Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted systematic searches on Scopus, PubMed, PsycINFO, Medline, and Web of Science (WoS) databases.A total of 17,044 articles were screened. Of these, 24 articles met the inclusion criteria and data were extracted. Twenty-one articles investigated psychological disorders, two articles studied emotions and their relationships with certain environmental factors, and one article explored cognitive functions in the exposed populations. These studies showed that highly exposed populations were more vulnerable to develop long-lasting psychological disorders than less exposed populations.The negative influence of experiencing volcanic activity on mental health was confirmed. Clearly, there is a need for more research to improve the mental health of the populations highly exposed to volcanic eruptions. Recommendations for future research are also included.",
"Predictions": [
"Mental Health"
],
@@ -212,7 +252,12 @@
"Mental Health",
"Mental Disorders",
"Environmental Exposure"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39734104",
@@ -236,7 +281,12 @@
"Surveys and Questionnaires",
"Students",
"Peer Group"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39734100",
@@ -256,13 +306,18 @@
"Pandemics",
"Peer Group",
"Socioeconomic Factors"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "30"
+ }
},
{
"PMID": "39732736",
"Title": "BMC psychology",
"ArticleTitle": "Factorial validation and invariance of the Academic Procrastination Scale in Colombian students.",
- "Abstract": "The Modified Academic Procrastination Scale (EPA-C) demonstrates adequate psychometric properties and is gender-invariant for assessing academic procrastination among Colombian university students. Moreover, it has an impact on the mental health and life satisfaction of these students.",
+ "Abstract": "Academic procrastination is an increasingly pertinent issue among university students, impacting their academic performance, interpersonal relationships, and emotional well-being. However, brief assessment tools for timely intervention are scarce, especially in the Colombian context. Therefore, this study aims to evaluate the psychometric properties of the academic procrastination scale and analyze its relationship with mental health and life satisfaction.A total of 805 Colombian university students were selected through convenience sampling. Their ages ranged from 17 to 35 years, with an average age of 20.4 years (SD\u2009=\u20093.0).\u00a0 RESULTS: The findings reveal a modified two-factor structure of the scale, with adequate fit indices (\u03c72\u2009=\u200965.65, df\u2009=\u200913, p\u2009<\u2009.001; CFI\u2009=\u2009.96, TLI\u2009=\u2009.93, RMSEA\u2009=\u2009.07 (90% CI .06 -\u2009.09), SRMR\u2009=\u2009.03) and loadings above .50. Furthermore, both factors of the scale exhibited high reliability, with Cronbach's alpha and McDonald's omega coefficients greater than .80. The scale was also found to be gender invariant. Lastly, academic procrastination correlates positively with mental health and negatively with life satisfaction, while mental health relates negatively to life satisfaction.The Modified Academic Procrastination Scale (EPA-C) demonstrates adequate psychometric properties and is gender-invariant for assessing academic procrastination among Colombian university students. Moreover, it has an impact on the mental health and life satisfaction of these students.",
"Predictions": [
"Mental Health"
],
@@ -283,13 +338,18 @@
"Mental Health",
"Surveys and Questionnaires",
"Factor Analysis, Statistical"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39732545",
"Title": "Endocrinologia, diabetes y nutricion",
"ArticleTitle": "Nurse-led therapeutic patient education program on glycemic control and emotional wellbeing in adolescents with type 1 diabetes mellitus during hospital transition.",
- "Abstract": "The structured therapeutic education program for adolescents with T1DM transitioning from pediatric to adult care maintains glycemic control and emotional wellbeing.",
+ "Abstract": "The transition of adolescents from pediatric to adult hospitals is a planned and guided process that involves changes in the focus, style, and location of care. During this period, complications are common in those with type 1 diabetes mellitus (T1DM). The objective of this study was to understand the influence of a nurse-led structured therapeutic education program on maintaining glycemic control and emotional wellbeing in these adolescents.Monocentric quasi-experimental clinical trial of a single group. SPSS and R-Commander were used for statistical analysis, including Student's t-test, Wilcoxon test, Cohen's d, Rosenthal's r, and multivariate linear regression analysis.A total of 15 adolescents with a 5-to-17-year history of the disease participated in the study. They had a BMI of 18-26.3kg/m and were on basal-bolus therapy. No significant differences were found in glycemic control and emotional wellbeing between baseline values and at 3 months. A significant difference in self-care was observed at 12 months. Family function and eating disorders were positively associated at baseline, 3 months, and 12 months.The structured therapeutic education program for adolescents with T1DM transitioning from pediatric to adult care maintains glycemic control and emotional wellbeing.",
"Predictions": [
"Mental Health",
"Diabetes type 1"
@@ -307,7 +367,43 @@
"Emotions",
"Mental Health",
"Feeding and Eating Disorders"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "39731866",
+ "Title": "Social science & medicine (1982)",
+ "ArticleTitle": "Economic hardships during COVID-19 and maternal mental health: Combining samples with low incomes across three cities.",
+ "Abstract": "The COVID-19 pandemic increased maternal depression and anxiety, imperiling both mothers' own wellbeing and that of their children. To date, however, little is known about the extent to which these increases are attributable to economic hardships commonly experienced during the pandemic: income loss, job loss, and loss of health insurance. Few studies have examined the individual impacts of these hardships, and none have lasted beyond the first year of the pandemic. This study harmonizes data from six evaluations of pediatric-based parenting programs for women with young children and low incomes across three U.S. cities (N\u00a0=\u00a01,254). Low-income mothers are of special interest because their families have been disproportionately affected by economic shocks due to COVID-19, and mothers of young children have been more distressed than other mothers by COVID-19. The studies' combined window of observation lasted from the onset of the pandemic to over three years later. Results indicate that income loss, job loss, and health insurance loss were all significantly associated with depression and anxiety. When each hardship was assessed net of the others, lost income was associated with more than a two-fold increase in the odds of anxiety, and a lost job and lost health insurance were associated with 50% and 90% greater odds of depression, respectively. Associations between hardships and maternal mental health did not diminish over time during the window of observation. These associations are likely to have been even greater in the absence of generous social policies enacted during the pandemic.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Female",
+ "Adult",
+ "Mothers",
+ "Poverty",
+ "United States",
+ "Mental Health",
+ "Depression",
+ "Anxiety",
+ "Pandemics",
+ "Maternal Health",
+ "Cities",
+ "SARS-CoV-2",
+ "Unemployment"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
},
{
"PMID": "39731523",
@@ -325,13 +421,18 @@
"Social Theory",
"Mental Health",
"Health Status Disparities"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39731316",
"Title": "Nordic journal of psychiatry",
"ArticleTitle": "Gender-stratified national mental health norms of BSI-53, BSI-18, SCL-10, ADHD-9, and ADHD-6 for Denmark.",
- "Abstract": "This study provides gender-stratified Danish mental health norms for multiple symptom scales. The considerable gender differences in the SCL-10 underscore the importance of gender-specific norms. The 2020 SCL-10 norms are biased by COVID-19 distress. Until new normative data is available, the gender-specific norms provided here are recommended.",
+ "Abstract": "Reliable gender-sensitive normative data is needed to facilitate mental health research and clinical utility of commonly used symptoms scales. This study establishes Danish gender-stratified norms for the 53-item and 18-item Brief Symptom Inventory (BSI-53, BSI-18), proposed attention deficit hyperactivity disorder (ADHD) symptomatology scales from the BSI-53, and the 10-item Symptom Checklist (SCL-10). This study also examines gender-differences in symptom reporting of the ADHD and SCL-10 scales, and assesses potential bias in recent SCL-10 norms.Norms for the BSI-53, BSI-18, two ADHD scales and SCL-10 were established using archived Hopkins Symptom Checklist 90-R (SCL-90R) normative data collected in spring 2000 (\u2009=\u20091079, age 18-80, 53% female). SCL-10 norms from 2000 were compared with proposed norms collected in spring 2020 (\u2009=\u20092819, age 18-80, 55% female) during the first COVID-19 lockdown in Denmark, and with first-episode depression patients from 2020 to 2023 (\u2009=\u2009221, age 18-65, 73% female).The scales showed high internal consistencies (McDonald's \u2009>\u20090.81), except for 4-5 item scales (\u2009>\u20090.73). Women scored higher on both ADHD scales (Cohen's \u2009=\u20090.15 and 0.19, \u2009\u2264\u20090.019). Women scored higher on the SCL-10 in the 2000 population sample (\u2009=\u20090.22, \u2009<\u20090.0001) and in patients (\u2009=\u20090.44, \u2009=\u20090.004). The average population SCL-10 score in 2000 was lower than 2020 (\u2009=\u20090.52, \u2009<\u20090.001).This study provides gender-stratified Danish mental health norms for multiple symptom scales. The considerable gender differences in the SCL-10 underscore the importance of gender-specific norms. The 2020 SCL-10 norms are biased by COVID-19 distress. Until new normative data is available, the gender-specific norms provided here are recommended.",
"Predictions": [
"Mental Health"
],
@@ -352,7 +453,38 @@
"Reference Values",
"Brief Psychiatric Rating Scale",
"Mental Health"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "39730780",
+ "Title": "Journal of urban health : bulletin of the New York Academy of Medicine",
+ "ArticleTitle": "Association Between Residential Exposure to Road Traffic Noise and Psychological Health in Preschool Children.",
+ "Abstract": "Environmental noise pollution is one of the biggest concerns and the most important challenges in urban areas. Evidence from epidemiological studies shows that acoustic pollution can impact human health, and the effects may be stronger in susceptible and sensitive individuals. The objective of the study was to determine the individual exposure to road transport noise for preschool children in the residential environment and to assess its impact on children's psychological health. This is the first representative large-scale noise impact study in Lithuania aimed at the psychological health of children. A total of 1457 parent-child pairs were involved in the study. Residential exposure to environmental noise caused by road transport in Kaunas agglomeration, Lithuania was determined by applying geographic information systems and strategic noise mapping. A standardized Strengths and Difficulties Questionnaire (SDQ) was used to assess psychological health problems in children. Multivariate logistic regression analysis was used to determine the association between residential exposure to environmental noise caused by road transport and children's psychological health. The results of the study showed that the risk of hyperactivity and total scale difficulties increased statistically significantly up to 77% and up to 48%, respectively, in the highest noise (L\u2009\u2265\u200950\u00a0dB) exposure. The obtained results provide new knowledge about the relationship between road traffic noise in the residential environment and the psychological health of preschool children.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Child, Preschool",
+ "Female",
+ "Noise, Transportation",
+ "Environmental Exposure",
+ "Lithuania",
+ "Mental Health",
+ "Surveys and Questionnaires",
+ "Geographic Information Systems"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39730730",
@@ -373,7 +505,12 @@
"Sleep",
"Cross-Sectional Studies",
"Surveys and Questionnaires"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39730531",
@@ -398,7 +535,12 @@
"Universities",
"Mental Health",
"Surveys and Questionnaires"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39730236",
@@ -423,13 +565,18 @@
"Sleep",
"Surveys and Questionnaires",
"Circadian Rhythm"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39729870",
"Title": "Environment international",
"ArticleTitle": "Life in green: Associations between greenspace availability and mental health over the lifecourse - A 40-year prospective birth cohort study.",
- "Abstract": "This study supports the protective effects of greenspace on adult depressive symptoms, highlighting the significance of employing a spatial lifecourse epidemiology framework to examine the long-term effects of environmental factors on health over the lifecourse.",
+ "Abstract": "The beneficial impacts of greenspace availability on mental health are well-documented. However, longitudinal evidence using a spatial lifecourse perspective is rare, leaving the dynamics of how greenspace influences mental health across the lifecourse unclear. This study first uses prospective birth cohort data to examine the associations between greenspace availability in childhood (0-16\u00a0years) and mental health in adolescence (16\u00a0years) and between greenspace availability and mental health across adulthood (18-40\u00a0years).Data were obtained from the Christchurch Health and Development Study, comprised 1,265 cohort members born in Christchurch, New Zealand, in 1977. Mental health outcomes including depressive symptoms, anxiety disorders and suicidal ideation were assessed in adolescence (16\u00a0years), and in adulthood (18-40\u00a0years). Greenspace availability from birth to age 40\u00a0years was measured as the proportion of vegetated areas within circular buffers (radius from 100m to 3000m) around members' geocoded residential addresses using a time-series impervious surfaces data from 1985 to 2015. Bayesian Relevant Lifecourse exposure models examined the associations between childhood greenspace availability and adolescent mental health and tested for critical/sensitive age periods. Generalised Estimating Equation logistic regression models assessed the associations between greenspace availability and mental health across adulthood. These analyses were adjusted for various important individual, family, and area-level covariates.No associations were found between childhood greenspace availability and any adolescent mental health conditions. However, in adulthood, a one standard deviation increase in greenspace availability within 1500m and 2000m buffers was associated with a 12% and 13% reduced risk of depressive symptoms, respectively, after adjusting for various covariates.This study supports the protective effects of greenspace on adult depressive symptoms, highlighting the significance of employing a spatial lifecourse epidemiology framework to examine the long-term effects of environmental factors on health over the lifecourse.",
"Predictions": [
"Mental Health"
],
@@ -450,13 +597,18 @@
"Parks, Recreational",
"Infant, Newborn",
"Depression"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
"PMID": "39729805",
"Title": "Drug and alcohol dependence",
"ArticleTitle": "Tobacco cessation, mental health, and substance use in a community pharmacist-linked cessation program for people experiencing homelessness.",
- "Abstract": "A community pharmacist-linked cessation program in homeless shelters was associated with reduced consumption and increased weekly quit attempts, highlighting its potential for scalability among people experiencing homelessness with high rates of co-occurring behavioral health conditions.",
+ "Abstract": "The prevalence of tobacco use among people experiencing homelessness is 70\u2009%. Mental health and substance use disorders are associated with tobacco use and pose challenges for tobacco cessation.Between 2019 and 2024, we recruited 206 adults experiencing homelessness from three homeless shelters in San Francisco, California. Participants were enrolled in a 12-week pharmacist-linked smoking cessation program that involved pharmacist counseling and furnishing of nicotine replacement therapy (NRT) and brief cessation coaching by trained shelter staff. We examined the association of provision of tobacco cessation interventions with two outcomes-weekly cigarette consumption and quit attempts-using mixed effects Poisson and logistic regression models respectively. We ran separate models with baseline mental health conditions and substance use disorders and adjusted for age, gender, race-ethnicity, time to first cigarette after waking, and baseline cigarette consumption in all models.Adjusting for baseline mental health conditions and other covariates, the use of pharmacist-furnished NRT was associated with lower weekly consumption (Incidence Rate Ratio [IRR]: 0.74, 95\u2009% Confidence Interval [CI]: 0.71-0.76) and increased weekly quit attempts (Adjusted Odds Ratio (AOR): 1.78, 95\u2009% CI: 1.23-2.58). After adjusting for baseline substances used and other covariates, use of pharmacist-furnished NRT was associated with lower weekly consumption (IRR: 0.74, 95\u2009% CI: 0.73-0.76) and increased weekly quit attempts (AOR: 1.99, 95\u2009% CI: 1.45-2.74).A community pharmacist-linked cessation program in homeless shelters was associated with reduced consumption and increased weekly quit attempts, highlighting its potential for scalability among people experiencing homelessness with high rates of co-occurring behavioral health conditions.",
"Predictions": [
"Mental Health"
],
@@ -484,157 +636,133 @@
"Time Factors",
"Diagnosis, Dual (Psychiatry)",
"Mental Disorders"
- ]
- },
- {
- "PMID": "39727705",
- "Title": "Current oncology (Toronto, Ont.)",
- "ArticleTitle": "Longitudinal Follow-Up of the Psychological Well-Being of Patients with Colorectal Cancer: Final Analysis of PICO-SM.",
- "Abstract": "PICO-SM was a prospective longitudinal study investigating the psychological impact of the COVID-19 pandemic on patients with colorectal cancer treated in a large UK tertiary cancer centre. Here, we present the impact of the third wave of the pandemic (December 2021 to February 2022), when the Omicron variant became prevalent in the UK, and the complete longitudinal comparison across the entire duration of this study. Patients were invited to complete a questionnaire, including screening psychometric tools. In total, n = 312 patients were included in the final analysis. Specifically, in this Omicron-predominant wave, n = 96 patients were studied in detail: the mean age was 64 years, 64% were male, 33% reported poor well-being, 27% anxiety, 11% depressive symptoms, and 3% trauma-related symptoms. The participants who had investigations cancelled (OR 9.22, 95% CI 1.09-77.85; ",
- "Predictions": [
- "Mental Health"
],
- "MeshTerms": [
- "Humans",
- "Male",
- "Colorectal Neoplasms",
- "Middle Aged",
- "COVID-19",
- "Female",
- "Longitudinal Studies",
- "Aged",
- "Anxiety",
- "Prospective Studies",
- "SARS-CoV-2",
- "Depression",
- "Follow-Up Studies",
- "Surveys and Questionnaires",
- "Mental Health",
- "United Kingdom",
- "Psychological Well-Being"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
- "PMID": "39727168",
- "Title": "European journal of pain (London, England)",
- "ArticleTitle": "Monitoring Chronic Non-Cancer Pain in Denmark Over Two Decades: Prevalence, Mental Health and Loneliness.",
- "Abstract": "This study demonstrated alarming trend on chronic non-cancer pain prevalence over time in Denmark. The high estimates of prevalence and related issues, such as mental health and severe loneliness deserve further investigation and prioritisation in the public health agenda.",
+ "PMID": "39729758",
+ "Title": "Currents in pharmacy teaching & learning",
+ "ArticleTitle": "Mental health indicators in pharmaceutical sciences students during the COVID-19 pandemic.",
+ "Abstract": "The COVID-19 pandemic changed the daily lives of university students and affected their mental health. The aim of this study was to assess the feelings and perceptions regarding the pandemic and teaching, and to identify the mental health symptoms perceived by pharmaceutical sciences students at a Brazilian public university.This is a cross-sectional study with data triangulation (mixed-methods approach), conducted online with semiannual data collection from May 2020 to May 2021. The Depression, Anxiety, and Stress Scale (DASS-21) and 4 open-ended questions (concerns and perceptions about education and feelings during the pandemic) were used. To identify key indicators of mental health symptoms a network analysis was conducted. The qualitative data were analyzed by similarity and collective subject discourses methods.There were 682 responses to the study (phase 1: n\u00a0=\u00a0153; phase 2: n\u00a0=\u00a0254; phase 3: n\u00a0=\u00a0275). Most of them were female (67.0-77.8\u00a0%) and reported symptoms of anxiety (89.5-93.3\u00a0%), distress (72.5-76.3\u00a0%), fear (58.8-71.6\u00a0%), and insomnia (66.5-72.4\u00a0%). The DASS-21 indicators: \"I found myself getting agitated,\" \"I felt downhearted and blue\" and \"I felt that life was meaningless\" had greater strength for maintaining the network. Among self-reported symptoms, tachycardia was the network central node. The students raised topics about mental health, teaching, uncertainties, and health protocols and three concerns were health, college, and COVID-19.There was a high prevalence of mental health symptoms among students. The disruption of the relationship system, instructional model, and future expectations may have influenced this prevalence.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Denmark",
- "Loneliness",
+ "COVID-19",
+ "Cross-Sectional Studies",
"Female",
- "Middle Aged",
"Male",
- "Chronic Pain",
- "Prevalence",
- "Adult",
- "Aged",
+ "Brazil",
"Mental Health",
- "COVID-19",
+ "Students, Pharmacy",
+ "Surveys and Questionnaires",
+ "Adult",
+ "Stress, Psychological",
+ "Anxiety",
+ "Pandemics",
+ "Depression",
+ "SARS-CoV-2",
"Young Adult",
- "Adolescent",
- "Aged, 80 and over",
- "Surveys and Questionnaires"
- ]
- },
- {
- "PMID": "39727091",
- "Title": "JMIR mental health",
- "ArticleTitle": "Implementing Findable, Accessible, Interoperable, Reusable (FAIR) Principles in Child and Adolescent Mental Health Research: Mixed Methods Approach.",
- "Abstract": "By systematically listing these barriers and providing recommendations, we intend to enhance the awareness of researchers and grant providers that making data FAIR demands specific expertise, available tooling, and proper investments.",
- "Predictions": [
- "Mental Health"
+ "Universities"
],
- "MeshTerms": [
- "Humans",
- "Adolescent",
- "Child",
- "Mental Health",
- "Biomedical Research",
- "Delphi Technique",
- "Mental Health Services"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
},
{
- "PMID": "39726658",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Increased physical activity frequency in primary school adolescents is related to reduced risk of self-reported adverse mental health symptoms.",
- "Abstract": "Given the dose-response relationship between poor mental health and lack of physical activity, it is necessary to actively promote primary school students to participate more actively in physical activities.",
+ "PMID": "39729215",
+ "Title": "International archives of occupational and environmental health",
+ "ArticleTitle": "Causal effects of promotion to managerial positions on mental health and satisfaction in Japanese male workers.",
+ "Abstract": "We estimated the static and dynamic effects of promotion to managerial positions on mental health and satisfaction using the recent estimation method; we addressed the gap in extant research by considering the heterogeneity in treatment timing to reconfirm evidence regarding the causal effects of promotion.We used a modified estimation method of two-way fixed effects recommended by (Callaway and Sant'Anna, J Econom 225:200-230, 2021). To check for robustness, we compared the analyses using propensity sample matching, an alternative treatment timing heterogeneity-robust analysis, and a normal two-way fixed effects event study. We used four years of complete panel data on a sample of 1454 Japanese males (5816 overall).The results indicated that becoming a manager worsened mental health with a two-year lag. We tested the effects of promotion to managerial positions on variables shown in previous studies to have negative effects on mental health (e.g., increased working hours) and positive effects (e.g., increased job role clarity) as outcomes to explore the mechanisms. Some of both variables indicate statistical significance. These results were robust.The promotion to managerial positions deteriorated mental health with a two-year lag. Promotion to managerial positions exhibited both positive and negative effects. The findings have potential implications for firms' human resources allocation.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
"Male",
- "Female",
- "Exercise",
- "Self Report",
- "Adolescent",
- "Students",
- "China",
- "Child",
- "Schools",
+ "Japan",
"Mental Health",
+ "Adult",
+ "Job Satisfaction",
+ "Middle Aged",
"Surveys and Questionnaires",
- "Health Surveys",
- "Sedentary Behavior",
- "Depression"
- ]
+ "East Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
- "PMID": "39726069",
- "Title": "The International journal of artificial organs",
- "ArticleTitle": "Comparing mental health and substance use disorders in patients receiving durable VADs versus transplants: A TriNetX database analysis.",
- "Abstract": "Ventricular assist device (VAD) and cardiac transplant patients experience significant strain on their physical and mental wellbeing postoperatively. Mental health and substance use disorders (MHDs and SUDs) have substantial effects on the quality of life and compliance of transplant and VAD patients. In this study, we compare and characterize MHDs and SUDs between VAD and cardiac allograft patients and transplant list patients with and without VADs. This study compares the incidence of MHDs and SUDs between VAD and cardiac transplant patients. Cohorts were defined using ICD-10 codes in TriNetX, a large public database. Patient characteristics were matched by using propensity score matching. Incidence was analyzed using the log-rank test. Statistical significance was set at ",
+ "PMID": "39727705",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Longitudinal Follow-Up of the Psychological Well-Being of Patients with Colorectal Cancer: Final Analysis of PICO-SM.",
+ "Abstract": "PICO-SM was a prospective longitudinal study investigating the psychological impact of the COVID-19 pandemic on patients with colorectal cancer treated in a large UK tertiary cancer centre. Here, we present the impact of the third wave of the pandemic (December 2021 to February 2022), when the Omicron variant became prevalent in the UK, and the complete longitudinal comparison across the entire duration of this study. Patients were invited to complete a questionnaire, including screening psychometric tools. In total, n = 312 patients were included in the final analysis. Specifically, in this Omicron-predominant wave, n = 96 patients were studied in detail: the mean age was 64 years, 64% were male, 33% reported poor well-being, 27% anxiety, 11% depressive symptoms, and 3% trauma-related symptoms. The participants who had investigations cancelled (OR 9.22, 95% CI 1.09-77.85; = 0.041) or felt that the pandemic would affect their mental health (OR 3.82, 95% CI 1.96-7.44; < 0.001) had an increased risk of anxiety according to a multivariate analysis. Similarly, independent predictors of poor well-being included concern that the pandemic would affect their cancer treatment (OR 4.59, 95% CI 1.03-20.56; = 0.046) or mental health (OR 3.90, 95% CI 1.38-11.03; = 0.010). The psychological distress experienced by patients, particularly anxiety, remained high during the third wave of the COVID-19 pandemic. These results align with our previously reported findings, emphasising the importance of continuing cancer treatment amidst an ongoing humanitarian emergency.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
"Male",
- "Female",
- "Substance-Related Disorders",
+ "Colorectal Neoplasms",
"Middle Aged",
- "Heart Transplantation",
- "Heart-Assist Devices",
- "Adult",
- "Databases, Factual",
- "Incidence",
- "Mental Health",
- "Quality of Life",
+ "COVID-19",
+ "Female",
+ "Longitudinal Studies",
"Aged",
- "Mental Disorders",
- "Waiting Lists",
- "Risk Factors"
- ]
+ "Anxiety",
+ "Prospective Studies",
+ "SARS-CoV-2",
+ "Depression",
+ "Follow-Up Studies",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "United Kingdom",
+ "Psychological Well-Being"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
- "PMID": "39725888",
- "Title": "BMC pregnancy and childbirth",
- "ArticleTitle": "Mental health risks in pregnancy and early parenthood among male and female parents following unintended pregnancy or fertility treatment: a cross-sectional observational study.",
- "Abstract": "N/A (non-interventional study).",
+ "PMID": "39727332",
+ "Title": "Journal of occupational health",
+ "ArticleTitle": "Techno-strain and techno-insecurity are associated with poor mental well-being in specific age and occupation groups.",
+ "Abstract": "Innovative technology at work can lead to stress and has been linked with adverse work and health consequences. This study aimed to examine the association of techno-insecurity and techno-strain with mental well-being in different age and occupational groups.We used a nationally representative survey of the working population and restricted our analyses to 2814 employees who reported being engaged with new technology. Techno-insecurity and techno-strain were evaluated by a single question each. Mental health status was assessed by a 5-item scale, and burnout status was assessed by the Copenhagen Burnout Inventory. We used logistic regression analysis to examine the association of techno-insecurity and techno-strain with mental well-being, adjusting for job control, psychological demands, job insecurity, and workplace violence. We further stratified study participants by age and occupational group and examined the association in each group.One-fifth of the study participants reported having techno-insecurity and techno-strain. Techno-insecurity was associated with a 1.8-fold increased risk of poor mental health and high burnout, whereas techno-strain was associated with a 2.2-fold increased risk of having poor mental health and high burnout. The associations between techno-insecurity or techno-strain and poor mental health were most profound among middle-aged workers. Among all occupational groups, the associations between techno-insecurity or techno-strain and burnout were most profound among manual workers.Techno-strain and techno-insecurity are emerging occupational mental health threats, particularly among middle-aged and manual workers. To promote mental health, resources provided by the organization are needed to help employees cope and work with technology.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Pregnancy",
"Adult",
- "Cross-Sectional Studies",
- "Pregnancy, Unplanned",
- "Parents",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Burnout, Professional",
+ "Occupational Stress",
"Mental Health",
- "Reproductive Techniques, Assisted",
+ "Occupations",
+ "Age Factors",
+ "Surveys and Questionnaires",
"Young Adult",
- "Stress, Psychological",
- "Surveys and Questionnaires"
- ]
+ "Technology",
+ "Inventions"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
"PMID": "39725758",
@@ -656,1673 +784,1751 @@
"Suicide",
"Female",
"Mental Disorders"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
},
{
- "PMID": "39724226",
- "Title": "PloS one",
- "ArticleTitle": "Psychosocial work stressors and mental health in Ph.D. students in Germany-Evidence from two cross-sectional samples.",
- "Abstract": "Both study samples showed high prevalence of mental health symptoms and effort-reward imbalance also in comparison to other research findings. An imbalance between effort and reward, boundary permeability and leader support show the most strongly associations with mental health symptoms and perceived stress. Future longitudinal studies could help to support our findings in terms of a causal stressor-strain association. Universities should focus on mental health of Ph.D. students and direct their support towards promoting student-supervisor relationships and clear guidelines for Ph.D. students' working hours.",
+ "PMID": "39709183",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Promoting Women's Mental Health Across the Life Course.",
+ "Abstract": "The guest editors for this series describe the importance of a life course perspective to women's mental health and introduce the articles in the issue.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
"Female",
- "Male",
- "Germany",
- "Cross-Sectional Studies",
"Mental Health",
- "Adult",
- "Surveys and Questionnaires",
- "Young Adult",
- "Stress, Psychological",
- "Students",
- "Occupational Stress",
- "Universities"
- ]
+ "Women's Health",
+ "Health Promotion"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39724125",
- "Title": "Psychiatria Danubina",
- "ArticleTitle": "MENTAL HEALTH OUTCOMES IN COVID-19 SURVIVORS: ROLE OF CLINICAL PREDICTORS.",
- "Abstract": "The COVID-19 pandemic had a major worldwide impact resulting in more than 7 million deaths due to COVID-19. Mental health issues, including anxiety, depression, and post-traumatic stress disorder (PTSD) have been observed in COVID-19 survivors worldwide. This study aimed to investigate the psychological impact of COVID-19 survivors three months after discharge from hospital and examine associated risk factors. 186 COVID-19 patients were assessed at baseline and three months after hospital discharge using questionnaires for depression, anxiety, insomnia, and post-traumatic stress symptoms (PTSD). Medical data, including comorbidities, complications, and psychiatric history, were collected, and analyzed. The study found a prevalence of PTSD, anxiety, and depression symptoms of 14%, 14% and 10.8% respectively three months after hospital discharge. Female gender was a risk factor for PTSD (OR 4.54), depression (OR 3.55) and anxiety (OR 3.06). Patients with psychiatric history were at higher risk of depression (OR 8.46) and anxiety (OR 4.00) but not of PTSD. No association was found with other clinical variables including inflammation markers. The prevalence of psychopathological outcomes in COVID-19 survivors in this study was increased compared to the general population and in line with previous research. Female gender and psychiatric history increased the risk of anxiety and depression. The absence of correlation between inflammation or other clinical variables and psychopathological outcome measures is discussed in comparison with prior research. More research is needed to understand these associations and the long-term effects of COVID-19 on mental health.",
+ "PMID": "39709182",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Racial Categorization in Women's Mental Health Research Fails to Meet the Needs of Multiracial, Biracial, and Mixed-Race Women in the United States.",
+ "Abstract": "The author challenges women's mental health researchers to critically examine the categories of race available for research participants, surveillance data, and medical records.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
"Female",
- "Male",
- "Stress Disorders, Post-Traumatic",
- "Survivors",
- "Middle Aged",
- "Adult",
- "Anxiety",
- "Risk Factors",
- "Depression",
- "Prevalence",
- "Aged",
- "Comorbidity",
- "Sex Factors",
- "Sleep Initiation and Maintenance Disorders",
- "Mental Health"
- ]
- },
- {
- "PMID": "39724115",
- "Title": "Psychiatria Danubina",
- "ArticleTitle": "GLOBAL MENTAL HEALTH ENLIGHTENMENT AND CULTURE OF EMPATHY: HOW TO NAVIGATE A WORLD IN EXISTENTIAL CRISIS AND WARS?",
- "Abstract": "A global culture of empathy appears crucial for the survival of humankind and life on our planet. There is no health without mental health and no mental health without a culture of empathy at all levels: individual, family, national, and global. Similarly, there is no global security without peace, and no peace without a culture of empathy. While peace is associated with mental health promotion, wars are associated with poor or ill mental health. Humanity needs a fresh goal for global peace and sustainability that promotes the culture of empathy to prevent millions of innocent victims from dying, becoming ill, or being maimed. Education focusing on empathy, peace, and mental health literacy forms the foundation for a better future for all and Earth's sustainability. If we, as Homo sapiens - beings capable of foresight, choice, and action - are to survive, there must be New Enlightenment: a positive vision of an empathetic form of globalization for all humankind.",
- "Predictions": [
+ "United States",
+ "Women's Health",
+ "Racial Groups",
"Mental Health"
],
- "MeshTerms": [
- "Humans",
- "Empathy",
- "Global Health",
- "Mental Health",
- "Existentialism",
- "Warfare"
- ]
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39724057",
- "Title": "PloS one",
- "ArticleTitle": "Depression in the COVID-19 endemic era: Analysis of online self-disclosures by young South Koreans.",
- "Abstract": "Although COVID-19 has been declared endemic in South Korea, there are economic and psychosocial after-effects. One of these is the prevalence of depression. Depressed adolescents and young adults struggle with insecurity, loneliness, and lack of confidence due to the life limitations imposed during the pandemic. Young South Koreans experienced deterioration in mental health because of the recurrence of mass infections. To address professionals' concerns about the lingering effects of COVID-19 on youth mental health, we text-mined young South Koreans' online posts about depression during the pandemic and the endemic phases-from February 2020 to May 2023. We used a total of 1,740 selected posts (raw data publicly available on https://github.com/kimalexis1129/PLOS_endemic_depression.git) to explore the situational triggers, additional factors, and by-products of depression that have persisted during the endemic era. We used Latent Dirichlet allocation and Dirichlet-multinomial regression topic modeling methods in conjunction with sentiment analysis and mean comparison. The results showed that the pandemic and endemic topic models shared similarities, but emerging topics showed extended adversities such as adolescents' vulnerability to eating disorders and young adults' tendency to self-isolate. Comparisons between the levels of positive and negative affect during the pandemic and endemic eras revealed no significant changes in mood. We discussed the results in comparison with SARS and MERS precedents and from general and cultural perspectives.",
+ "PMID": "39708612",
+ "Title": "Economics and human biology",
+ "ArticleTitle": "The long-run and intergenerational impact of early exposure to the Great Chinese Famine of 1959-61 on mental health.",
+ "Abstract": "We study the effects of early exposure to the Great Chinese Famine on the mental health and subjective well-being of survivors as well as their offspring using data from the 2010 and 2014 waves of the China Family Panel Studies. Our analysis focuses on K6 scores, severe mental illness, and life dissatisfaction. We find that early exposure to the famine has impaired the mental health outcomes of women, but not men (i.e., the first generation). For the second generation, negative effects only show up among the sons of male famine survivors. Some preliminary evidence suggests that the mechanism for such transmission may have to do with the cultural son preference.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Adolescent",
- "Adult",
- "Female",
"Humans",
+ "China",
"Male",
- "Young Adult",
- "COVID-19",
- "Depression",
- "East Asian People",
"Mental Health",
- "Pandemics",
- "Republic of Korea",
- "Social Media"
- ]
+ "Female",
+ "Famine",
+ "Adult",
+ "Middle Aged",
+ "Mental Disorders",
+ "Sex Factors",
+ "Personal Satisfaction",
+ "Survivors",
+ "History, 20th Century",
+ "Starvation",
+ "East Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "22"
+ }
},
{
- "PMID": "39722713",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Multidimensional screen exposure and its impact on psychological well-being in toddlers.",
- "Abstract": "The amount of time spent using computers, mobile phones and VR devices and the proportion of exposure to noneducational content and fast-paced content were significantly associated with psychological problems among 2- to 3-year-old children.",
+ "PMID": "39706574",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Strategies to Improve Women's Mental Health Across the Life Course.",
+ "Abstract": "The authors describe four important strategies to improve women's mental health during the perinatal period and across the life course.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
"Female",
- "Male",
- "Child, Preschool",
- "Cross-Sectional Studies",
- "China",
- "Screen Time",
- "Surveys and Questionnaires",
"Mental Health",
- "Parents",
- "Psychological Well-Being"
- ]
+ "Women's Health",
+ "Pregnancy",
+ "Perinatal Care",
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "21"
+ }
},
{
- "PMID": "39722022",
- "Title": "BMC public health",
- "ArticleTitle": "Combating the mental health challenge of loneliness among urban youth: could finding meaning in life and experiencing thriving enhance their well-being?",
- "Abstract": "The findings suggest that cultivating a sense of meaning in life is crucial for reducing loneliness and promoting well-being among urban youth. Educational institutions and mental health agencies should develop programs that help individuals find and pursue meaningful activities to foster thriving. Future research should explore these dynamics in various cultural contexts and utilize longitudinal designs to confirm causality.",
+ "PMID": "39699544",
+ "Title": "Revista da Sociedade Brasileira de Medicina Tropical",
+ "ArticleTitle": "Chikungunya chronic arthralgia: impact on general and mental health and absenteeism from work.",
+ "Abstract": "This study investigated the self-rated general health, mental health, and work absenteeism among patients with laboratory-confirmed chikungunya.Telephone interviews were conducted with 63 patients \u226522 months after infection.Patients who reported (N=42) or did not report (N=21) chronic arthralgia, defined by duration \u226590 days, had different frequencies for low scores for general health (68.3% vs. 30.0%, respectively; prevalence ratio, 95% confidence interval: 2.3, 1.1-4.6), symptoms of depression (31.7% vs. 15.0%; 2.1, 0.7-6.6), symptoms of anxiety (43.9% vs. 35.0%; 1.3, 0.6-2.5), and work absenteeism (76.5% and 40.0%; 1.9, 0.9-4.2).Chikungunya chronic arthralgia impacts long-term health and work.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Loneliness",
- "Adolescent",
+ "Absenteeism",
"Male",
"Female",
- "Cross-Sectional Studies",
- "Urban Population",
- "Young Adult",
+ "Chikungunya Fever",
+ "Arthralgia",
+ "Middle Aged",
"Adult",
+ "Chronic Disease",
"Mental Health",
- "Surveys and Questionnaires"
- ]
+ "Cross-Sectional Studies",
+ "Depression",
+ "Young Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
},
{
- "PMID": "39720811",
- "Title": "Frontiers in public health",
- "ArticleTitle": "The impact of positive activities on mental health: the mediating role of positive emotion.",
- "Abstract": "We concluded that the participation level of positive activities still needs to be improved and positive activities improve mental health through positive emotion, which implied that positive activities, as an easily implementable measure, should be greatly encouraged in mental health policies. And older adults, female, people without spouse, middle and upper-middle-income individuals need to be paid more attention.",
+ "PMID": "39691047",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Beyond Traditional Practices: Innovating Workplace Mental Health in the Community.",
+ "Abstract": "Workplace mental health is a critical concern. Forty per cent of healthcare workers experience burnout, half intend to leave the profession and only 60% express satisfaction with the quality of care they provide. These statistics highlight the urgency for innovative and holistic approaches to support well-being within healthcare organizations. This article focuses on an organization that prioritizes the mental health of its 8,000 distributed staff. Guided by the values of love, life care and work with purpose, the organization implemented strategies to strengthen its culture, develop leadership and create supportive environments. Emphasis was placed on interventions to mitigate stress and fatigue. Successes and lessons learned are shared, offering a blueprint for other organizations.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
+ "Workplace",
+ "Burnout, Professional",
"Mental Health",
- "China",
- "Middle Aged",
- "Adult",
- "Emotions",
- "Surveys and Questionnaires",
- "Aged",
- "Adolescent",
- "Young Adult"
- ]
+ "Organizational Culture",
+ "Leadership",
+ "Health Personnel",
+ "Job Satisfaction",
+ "Ontario"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39719817",
- "Title": "Journal of psychosomatic research",
- "ArticleTitle": "Boosting integration of physical and mental health: The impact of increasing psychiatrists in general hospitals without psychiatric Ward.",
- "Abstract": "Despite often being underestimated due to cost constraints, having multiple full-time psychiatrists in a general hospital without a psychiatric ward is essential for supporting the broader scope needed to integrate physical and mental health services.",
+ "PMID": "39691046",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Promoting Psychological Health and Safety in Canadian Healthcare Organizations.",
+ "Abstract": "This article analyzes findings from the Health Standards Organization's new Global Workforce Survey (GWS). The GWS enables healthcare organizations to measure, analyze and benchmark their workforce's perceptions of working conditions, safety culture and care quality against peers. The GWS measures key features of The National Standard of Canada for Psychological Health and Safety in the Workplace (CSA Group and Bureau de normalisation du Qu\u00e9bec 2013; MHCC 2013). The article highlights how psychological health and safety in Canadian healthcare organizations can enhance the well-being of workers, improve patient care and ultimately contribute to a more effective healthcare system.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Hospitals, General",
- "Psychiatry",
- "Mental Health Services",
- "Japan",
- "Psychiatric Department, Hospital",
- "Referral and Consultation",
- "Mental Disorders",
- "Surveys and Questionnaires",
+ "Canada",
"Mental Health",
- "Psychiatrists"
- ]
+ "Occupational Health",
+ "Workplace",
+ "Health Personnel",
+ "Organizational Culture",
+ "Surveys and Questionnaires",
+ "Patient Safety",
+ "Safety Management"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39719755",
- "Title": "Environment international",
- "ArticleTitle": "The impact of long-term exposure to NO",
- "Abstract": "Recent increases in nitrogen dioxide (NO",
+ "PMID": "39691045",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Introduction to Mental Health in Healthcare Workplaces.",
+ "Abstract": "In the quest by health leaders to create the conditions necessary for the delivery of safe, high-quality care, this issue of () is pleased to offer some promising approaches and resources for establishing healthy workplaces. We are all too aware that the workforce - as the backbone of the health system - is facing severe pressures. The demand for healthcare workers is outpacing supply, which necessitates innovative solutions to retain those already in the system.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Adolescent",
"Humans",
- "Ozone",
+ "Workplace",
+ "Health Personnel",
"Mental Health",
- "Nitrogen Dioxide",
- "Male",
- "Female",
- "Child",
- "China",
- "Air Pollutants",
- "Environmental Exposure",
- "Schools",
- "Cross-Sectional Studies",
- "Air Pollution",
- "Students"
- ]
+ "Occupational Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
},
{
- "PMID": "39719653",
- "Title": "BMC psychology",
- "ArticleTitle": "Would you be healthier if you had more social capital? Focusing on university students' social media use in Japan.",
- "Abstract": "This study has implications for improving the health of young adults in the \"mobile x social era.\" In particular, we provide suggestions to help young adults improve their mental health.",
+ "PMID": "39670944",
+ "Title": "Indian journal of public health",
+ "ArticleTitle": "Calamities, the Subsequent School Closure, and Their Impact on Adolescents' Mental Health.",
+ "Abstract": "This article aims to understand the implications of calamities and the resulting school closures on the mental health of adolescents. The impact of calamities, such as natural disasters or pandemics, on school closures and adolescents' mental health is complex. It is crucial to provide the necessary support, resources, and interventions to help adolescents navigate these challenging times and minimize the long-term impact on their mental well-being.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Social Capital",
- "Students",
- "Social Media",
- "Japan",
- "Universities",
- "Male",
- "Female",
- "Young Adult",
+ "Adolescent",
"Mental Health",
- "Adult",
- "Loneliness",
- "Health Status",
- "Personality",
- "Adolescent"
- ]
+ "Schools",
+ "India",
+ "Disasters",
+ "COVID-19",
+ "Adolescent Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
},
{
- "PMID": "39716066",
- "Title": "BMC cardiovascular disorders",
- "ArticleTitle": "Quality of life after myocardial infarction in the pakistani population - insights from a single-center cohort study.",
- "Abstract": "Although a significant proportion of patients in our cohort reported good HRQoL post-MI, several social factors were associated with lower HRQoL. These factors must be investigated further in discharge planning and post-discharge of patients with MI.",
+ "PMID": "39667951",
+ "Title": "BMJ paediatrics open",
+ "ArticleTitle": "Future time perspectives and concerns among adolescents in 2022.",
+ "Abstract": "Future time perspectives (FTP) and future-related concerns in adolescence remain underexplored. We aimed to identify factors associated with limited FTP and describe future-related concerns. Data were drawn from a population-based sample of adolescents aged 14-17 participating in the SEROCoV-KIDS cohort study, in Geneva, Switzerland (October 2022). Of 329 adolescents, 56/329 (17%) reported limited FTP; determinants included prior low mental well-being, limited social support, sexual minority identity, academic difficulties and excessive screen time. Adolescents' main future-oriented concerns encompassed failure, education and climate change. These results underscore the need to address future perspectives/concerns among young people and implement interventions that strengthen adolescent resilience.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Adolescent",
"Humans",
"Male",
"Female",
- "Quality of Life",
- "Pakistan",
- "Myocardial Infarction",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Aged",
- "Health Status",
- "Risk Factors",
+ "Switzerland",
+ "Social Support",
"Mental Health",
- "Time Factors"
- ]
+ "Screen Time",
+ "Adolescent Behavior",
+ "Forecasting",
+ "Cohort Studies",
+ "Sexual and Gender Minorities"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
},
{
- "PMID": "39715637",
- "Title": "BMJ mental health",
- "ArticleTitle": "Data sharing in circadian rhythm and mental health research: current status, challenges, recommendations and future directions.",
- "Abstract": "Data sharing is a cornerstone of modern scientific research, playing a critical role in fostering greater collaboration, enhancing reproducibility, transparency and efficiency of scientific discoveries, and integrating diverse data sources. In circadian rhythm research, data sharing is particularly important due to the complexity and heterogeneity of the data, which includes molecular profiles, physiological measurements, clinical data and sensor-based data. UK research funders, such as Medical Research Council, Wellcome Trust and UK Research and Innovation, have established data-sharing policies to promote open science and enhance research transparency. Despite these policies, a recent assessment within the UK Circadian Mental Health Network (CMHN), which incorporates an analysis of publications from several countries, revealed that data sharing remains limited. Significant challenges including data complexity, privacy and ethical considerations, technical issues and entrenched academic culture are major barriers to progress. This perspective article highlights the current state of data sharing in circadian and mental health research, identifies key obstacles and compares these practices with broader trends. We also provide insights from principal investigators within the CMHN on the reasons for limited data sharing. To address these challenges, researchers can foster a culture of openness by seeking training, planning ahead in ethics processes and data management plans and using data outputs in research assessment. We outline CMHN's future plans to deliver training on Findable, Accessible, Interoperable, Reusable principles, offer data curation services and provide ethical guidelines. By adopting these strategies, we aim to improve data-sharing practices, ultimately advancing our understanding of circadian rhythms and their implications for mental health.",
+ "PMID": "39666495",
+ "Title": "The American psychologist",
+ "ArticleTitle": "A global context for population mental health: Commentary on Dodge et al. (2024).",
+ "Abstract": "Dodge et al. (2024) outlined the gap between population mental health needs and the current capacity of the U.S. health care system to provide necessary services. We add international examples and a global perspective to their observations. Unlike some nations, the mental health needs in the United States occur in the context of privatized, for-profit health care. Nations that offer population-based mental health services may have achieved greater success through the use of nontraditional providers and by leveraging technology. We suggest that both proactive and preventive interventions are needed to build a mentally healthy ecosystem in the United States. (PsycInfo Database Record (c) 2025 APA, all rights reserved).",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Biomedical Research",
- "Circadian Rhythm",
- "Information Dissemination",
- "Mental Health"
- ]
+ "United States",
+ "Mental Health Services",
+ "Mental Health",
+ "Mental Disorders",
+ "Global Health",
+ "Health Services Needs and Demand"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
},
{
- "PMID": "39715235",
- "Title": "PloS one",
- "ArticleTitle": "A comparative study of Venezuelan immigrants' pre- and post-migration concerns for their children in the United States and Colombia.",
- "Abstract": "Research suggests that forced migration may lead to cultural stress and psychological distress. However, little is known about immigrant parents' pre- and post-migration concerns for their children's welfare. The present study examined the concerns of Venezuelan parents who migrated to the United States versus those who migrated to Colombia, and whether post-migration concerns were related to cultural stressors, mental health, and cultural identity. A sample of 609 Venezuelan immigrants completed surveys and responded to an open-ended prompt asking about pre- and post-migration concerns for children's welfare. Lack of safety was the most common pre-migration concern for Venezuelans in the U.S., whereas lack of food was the most common pre-migration concern for Venezuelans in Colombia. More years in the destination country since arrival were linked to heightened economic concerns and reduced worries about family separation. A positive link emerged between national identity and health-related concerns for children following migration. This knowledge can inform policies and programs to better support immigrant families as they navigate the challenges of forced migration.",
+ "PMID": "39653464",
+ "Title": "Soins; la revue de reference infirmiere",
+ "ArticleTitle": "[Mental health of primary care nurses during the Covid-19 pandemic: a longitudinal study].",
+ "Abstract": "In a weakened healthcare system, the mental health of healthcare workers has become a priority issue. The aim of this longitudinal study was to assess the mental health of primary care nurses during the Covid-19 pandemic, using a postal survey. Four validated self-report questionnaires were used. The nurses reported mainly burnout symptoms and around 20% reported a post-traumatic stress.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Humans",
- "Colombia",
- "Emigrants and Immigrants",
- "Venezuela",
- "Female",
- "Male",
- "United States",
- "Child",
- "Adult",
- "Child Welfare",
- "Parents",
- "Stress, Psychological",
- "Surveys and Questionnaires",
- "Adolescent",
- "Middle Aged",
+ "Longitudinal Studies",
"Mental Health",
- "Child, Preschool"
- ]
+ "Primary Care Nursing",
+ "Nurses",
+ "COVID-19",
+ "Pandemics",
+ "Surveys and Questionnaires",
+ "Self Report",
+ "Burnout, Professional",
+ "Stress Disorders, Post-Traumatic",
+ "Humans",
+ "France",
+ "Postal Service"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
},
{
- "PMID": "39715113",
- "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
- "ArticleTitle": "Impact of the Covid-19 pandemic and state of war on the availability and quality of mental health services.",
- "Abstract": "Conclusions: Preparing for pandemics and public health crises is critical to ensuring access to mental health care and requires a comprehensive approach.",
+ "PMID": "39652410",
+ "Title": "Annals of the New York Academy of Sciences",
+ "ArticleTitle": "New York State Climate Impacts Assessment Chapter 07: Human Health and Safety.",
+ "Abstract": "New Yorkers face a multitude of health and safety risks that are exacerbated by a changing climate. These risks include direct impacts from extreme weather events and other climate hazards, as well as indirect impacts occurring through a chain of interactions. Physical safety, physical health, and mental health are all part of the equation-as are the many nonclimate factors that interact with climate change to influence health outcomes. This chapter provides an updated assessment of all these topics at the intersection of climate change, public health and safety, and equity in the state of New York. Key findings are presented below.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Ukraine",
- "Mental Health Services",
- "Health Services Accessibility",
- "Pandemics",
- "Quality of Health Care",
- "SARS-CoV-2",
+ "Climate Change",
+ "New York",
+ "Public Health",
+ "Safety",
"Mental Health"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39714844",
- "Title": "JAMA network open",
- "ArticleTitle": "Patterns of Social Connection Among Older Adults in England.",
- "Abstract": "This cohort study highlights the importance of considering multidimensional measures of social connection and understanding the nuance of its heterogenous patterns. Understanding the typologies of social connection has substantial implications for exploring modifiable risk factors for social disconnection and for understanding the mechanisms linking social connection to health-related outcomes.",
+ "PMID": "39651691",
+ "Title": "Ugeskrift for laeger",
+ "ArticleTitle": "[Screen use and the mental health of children and young people].",
+ "Abstract": "Child mental health and well-being have decreased globally, and a causal correlation with screens including smartphones and social media apps has been suggested. In this review, we provide an overview of the literature concerning the use of new screen devices, with an emphasis on smartphones and social media apps, and mental health outcomes. Most epidemiological studies, cross-sectional and longitudinal, show a correlation between high use and poor mental health, some bidirectional, particularly among teenage girls. Experimental design studies find improved well-being after interventions with screen time reduction.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Humans",
+ "Adolescent",
+ "Child",
"Female",
- "Male",
- "Aged",
- "England",
- "Middle Aged",
- "Longitudinal Studies",
- "Personal Satisfaction",
- "Cohort Studies",
- "Depression",
+ "Humans",
+ "Melanoma",
"Mental Health",
- "Health Status",
- "Social Support",
- "Health Behavior",
- "Cluster Analysis"
- ]
+ "Skin Neoplasms",
+ "Smartphone",
+ "Social Media"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "9"
+ }
},
{
- "PMID": "39713741",
- "Title": "Alcohol research : current reviews",
- "ArticleTitle": "Structural Stigma, Racism, and Sexism Studies on Substance Use and Mental Health: A Review of Measures and Designs.",
- "Abstract": "The structural determinant measures used in the studies reviewed were diverse. They addressed, for example, community opinions, the gender of legislators, economic vulnerability, financial loan discrimination, college policies, law enforcement, historical trauma, and legislative protections for sexual and gender minorities and for reproductive rights. Most of the structural determinant measures were constructed by combining multiple indicators into indexes or by merging indexes into composite indexes, although some studies relied on single indicators alone. The substance use and mental health outcome measures most frequently examined were related to alcohol and depression, respectively. The studies were conducted in numerous nations and drew samples from an array of groups, including, for example, patients who experienced overdoses from substance use, sexual and gender minorities, racial and ethnic minority groups, women, youth, migrants, and patients subject to involuntary psychiatric hospitalization. Most of the studies used passive-observational (correlational) research designs and, as a result, did not assess whether their structural determinant variables were causally related to substance use and mental health. Nevertheless, the studies reviewed can be used by public health proponents to foster awareness that a wide range of structural determinants correlate with the substance use and mental health of many groups within and across nations.",
+ "PMID": "39626152",
+ "Title": "Health affairs (Project Hope)",
+ "ArticleTitle": "Children's Mental Health: Living With Parents Who Had Adverse Childhood Experiences.",
+ "Abstract": "In 2021, 42.8\u00a0percent of US children ages\u00a05-17 lived with an adult who had at least four adverse childhood experiences (ACEs). We found differences in exposure by race and ethnicity, income, and public versus private insurance status. Childhood exposure to adult ACEs was negatively correlated with child mental health, particularly among children in low-income and publicly insured families.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Substance-Related Disorders",
- "Social Stigma",
- "Sexism",
+ "Child",
+ "Adverse Childhood Experiences",
+ "Female",
+ "Male",
+ "Adolescent",
"Mental Health",
- "Racism",
- "Mental Disorders"
- ]
+ "Child, Preschool",
+ "United States",
+ "Parents",
+ "Adult",
+ "Child Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39712316",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Impact of living arrangements and internet use on the mental health of Chinese older adults.",
- "Abstract": "Therefore, this study puts forward the following suggestions: first, to develop family care for older adults and pay attention to the positive role of intergenerational support in the mental comfort of older adults; second, it is imperative for the government and social service departments to assist older adults in establishing correct concepts of Internet use, enhancing their digital literacy, and improving their digital skills.",
+ "PMID": "39625032",
+ "Title": "La Revue du praticien",
+ "ArticleTitle": "[Effects of yoga on mental health].",
+ "Abstract": "EFFECTS OF YOGA ON MENTAL HEALTH. The literature is piling up on the effects of yoga on health in the three most studied areas: on the brain, stress and anxio-depressive symptoms. Following the \"evidence-based practice\" approach, studies highlight the positive effects of yoga practice at these different levels in a variety of adult populations. It also involves identifying the modalities of yoga practice (type, duration and frequency of session, etc.) commonly used in these studies, and ultimately benefiting from scientific evidence of their effect on health that can be used for interventions in the f ield.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Yoga",
"Humans",
- "Aged",
- "Female",
- "Male",
- "China",
"Mental Health",
- "Internet Use",
- "Middle Aged",
- "Residence Characteristics",
- "Aged, 80 and over",
- "Independent Living",
- "Surveys and Questionnaires",
- "Internet",
- "East Asian People"
- ]
+ "Depression",
+ "Stress, Psychological",
+ "Anxiety",
+ "Brain"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "3"
+ }
},
{
- "PMID": "39712299",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Neighborhood social environment and mental health of older adults in China: the mediating role of subjective well-being and the moderating role of green space.",
- "Abstract": "This study enriches the empirical research on neighborhood social environment and mental health. First of all, older adults living in communities with good safety conditions and high social trust are less affected by negative emotions and tend to have good mental health. Second, deeper neighborhood ties, higher social trust, and safer community environments help older adults to be less disturbed by negative situations, have a positive effect on their SWB, and indirectly promote mental health. At the same time, green space can provide a place for older adults to socialize, enhance the positive impact of neighborhood ties on SWB, and further promote the mental health of older adults. Finally, this study suggests that the government and community managers pay attention to the construction of neighborhood social environment and green space, and provide support for \"healthy community\" and \"healthy aging\" planning.",
+ "PMID": "39617612",
+ "Title": "Applied nursing research : ANR",
+ "ArticleTitle": "Mental health misconceptions among at-risk populations: The case of hotel workers.",
+ "Abstract": "Most hotel workers represent disadvantaged populations in the United States. Socioecological stress-related factors increase the risk for poor mental health outcomes, yet accounts of worker perceptions of mental health are scarce.We conducted five focus groups among 23 hotel room cleaners and individual interviews with six hotel managers.Four themes emerged: Mental health is related to mental illness, mental health is associated with being crazy, mental health can be controlled, and mental health is taboo yet universal.These findings indicate mental health is poorly understood among this population. Education and tailored interventions are needed to address adverse mental health outcomes.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "China",
"Mental Health",
- "Aged",
- "Social Environment",
- "Female",
"Male",
+ "Female",
+ "Adult",
+ "Focus Groups",
"Middle Aged",
- "Residence Characteristics",
- "Surveys and Questionnaires",
- "Neighborhood Characteristics",
- "Aged, 80 and over"
- ]
+ "United States",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "2"
+ }
},
{
- "PMID": "39711409",
- "Title": "Aerospace medicine and human performance",
- "ArticleTitle": "A Proposed Framework to Regulate Mental Health in Airline Pilots.",
- "Abstract": "The current regulatory approach to U.S. airline pilot mental health may have unintended negative consequences including healthcare avoidance and screening imprecision. An alternative approach should aim to address these factors while maintaining safety. The authors summarize the following related to mental health in U.S. airline pilots: 1) current regulatory approach and limitations, 2) available regulatory tools within the Sparrow fundamentals, and 3) a proposed novel regulatory approach. The authors propose the simultaneous utilization of multiple models to minimize the negative consequences of healthcare avoidance and screening imprecision. The proposed framework aims to address current limitations. Hoffman WR, Suh A, Sprott T, Manderson K, Snyder Q, Sparrow M, Tvaryanas A. A proposed framework to regulate mental health in airline pilots. Aerosp Med Hum Perform. 2024; 95(12):940-943.",
+ "PMID": "39615544",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Longitudinal Analysis in Maternal Mental Health Research.",
+ "Abstract": "The author describes a lifespan-based approach to understanding maternal depression and the statistical considerations essential for evaluating interventions.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Pilots",
- "Aerospace Medicine",
+ "Female",
+ "Longitudinal Studies",
+ "Pregnancy",
"Mental Health",
- "United States"
- ]
+ "Depression, Postpartum",
+ "Research Design",
+ "Adult",
+ "Mothers"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "1"
+ }
},
{
- "PMID": "39711341",
- "Title": "Aerospace medicine and human performance",
- "ArticleTitle": "Aerospace Medical Association Proposed Research Priorities for Mental Health and Safety in Aviation.",
- "Abstract": "Research is needed to identify how to optimize and screen mental health across aviation SSP. This effort identified six key research priorities to achieve that aim. Hoffman WR, Tvaryanas A, Snyder Q, Spyropoulos BP, Garcia D, Schroeder D, Fahnenbruck G, Trottier K, Overbo S, Santilhano W, Brinks E, Ndoye A, Bongers H, O'Shaughnessy R, Miranda E; Aerospace Medical Association Mental Health Research Subgroup. Aerospace Medical Association proposed research priorities for mental health and safety in aviation. Aerosp Med Hum Perform. 2024; 95(11):845-850.",
+ "PMID": "39612685",
+ "Title": "Maturitas",
+ "ArticleTitle": "A review on essential oils: A potential tonic for mental wellbeing in the aging population?",
+ "Abstract": "Mental wellbeing is crucial to a good quality of life. With progression in life, mental health can deteriorate, leading to multiple disorders, such as depression, anxiety, stress, and insomnia. Essential oils, from various sources, have a long history of use in aromatherapy. Herein, we review the current literature related to the psychological effects of essential oils, emphasizing their impact on mood regulation, stress reduction, sleep disturbances, and cognitive function. Various mechanisms, such as alterations to the neurotransmitter system, endocrine changes, and anti-oxidant activity are reviewed. The non-invasive nature of essential oils suggests they have a promising role as adjuncts to conventional therapies for improving the mental health of the aging population.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Aerospace Medicine",
+ "Oils, Volatile",
"Mental Health",
- "Delphi Technique",
- "Aviation",
- "Research",
- "Societies, Medical",
- "Occupational Health"
- ]
+ "Aging",
+ "Aromatherapy",
+ "Cognition",
+ "Quality of Life",
+ "Stress, Psychological",
+ "Affect",
+ "Antioxidants"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "30"
+ }
},
{
- "PMID": "39711028",
- "Title": "Epidemiology and psychiatric sciences",
- "ArticleTitle": "Twelve-month follow-up of a controlled trial of a brief behavioural intervention to reduce psychological distress in young adolescent Syrian refugees.",
- "Abstract": "Although EASE led to significant reductions in internalising problems, caregiver distress, and harsh disciplinary parenting at 3-months, these improvements were not maintained at 12 months relative to EUC. Scalable psychological interventions for young adolescents need to consider their ongoing mental health needs. Prospectively registered: ACTRN12619000341123.",
+ "PMID": "39612617",
+ "Title": "Economics and human biology",
+ "ArticleTitle": "Migrant well-being in Australia: Does locus of control matter?",
+ "Abstract": "Using rich longitudinal data from Australia, we investigate the mental health impacts and behaviours of migration resettlement in Australia, focusing on age, gender and locus of control as possible modifiers. We find that age profiles in mental health differ significantly between migrant and native populations. Our analysis of second-generation migrants supports the 'healthy migrant paradox', suggesting favourable mental health outcomes. Additionally, we show that immigrants with an internal locus of control exhibit a lower likelihood of mental health issues, which suggests that an internal locus of control amplifies the beneficial effects in the case of mental health outcomes for immigrant populations.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Adolescent",
- "Refugees",
- "Syria",
- "Psychological Distress",
+ "Australia",
"Female",
- "Jordan",
"Male",
- "Follow-Up Studies",
- "Child",
- "Single-Blind Method",
- "Stress Disorders, Post-Traumatic",
- "Depression",
- "Stress, Psychological",
- "Behavior Therapy",
- "Mental Health"
- ]
+ "Adult",
+ "Mental Health",
+ "Middle Aged",
+ "Internal-External Control",
+ "Longitudinal Studies",
+ "Young Adult",
+ "Age Factors",
+ "Adolescent",
+ "Sex Factors",
+ "Transients and Migrants",
+ "Emigrants and Immigrants",
+ "Aged",
+ "Socioeconomic Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "30"
+ }
},
{
- "PMID": "39710807",
- "Title": "International journal of mental health nursing",
- "ArticleTitle": "The Relationship Between Resilience and Mental Health Status Among Nurses With Workplace Violence Experiences: A Cross-Sectional Study.",
- "Abstract": "Nurses encounter many stressors and challenges at work, which can negatively affect their mental and physical health. Modern theories of resilience suggest that resilience is a dynamic process of positive adaptation to adversity. This process involves personal growth through adversity, developing effective coping strategies and inculcating the ability to cope with stress. The resilience process involves individual characteristics, social support and environmental factors, including workplace culture. Strengthening nurses' resilience can help them cope with adversity, maintain their mental health and well-being and support their provision of care. The aim of this study was to examine the associations between workplace characteristics, resilience and mental health status among nurses with experiences of workplace violence. The study objectives were to analyse the relationships between workplace characteristics, resilience and mental health status among nurses with experiences of workplace violence and to investigate the effects of resilience on nurses' mental health outcomes. In this cross-sectional study, full-time nurses at a medical centre in Taiwan completed a questionnaire survey. Of 600 distributed questionnaires, 334 nurses were identified to have experienced workplace violence. The questionnaires included items on workplace violence, resilience, metal health status (burnout and mental distress), sleep quality, work characteristics (job control, psychological job demands and workplace justice) and demographic characteristics. Data were analysed through chi-square tests and multivariate logistic regression. Nurses with low resilience tended to be younger, work more rotating/night shifts and perceive lower levels of job control and workplace justice. They also reported higher risks of burnout and mental distress and lower sleep quality. Multivariate logistic regression revealed that psychological job demands, workplace justice and resilience significantly influenced nurses' mental health status. Nurses with high resilience exhibited a lower risk of mental distress and higher sleep quality. However, resilience was not associated with burnout. The findings revealed how workplace factors and resilience influence nurses' mental health. The findings help nurse managers and policymakers develop strategies to promote nurses' resilience and mental health and mitigate the adverse effects of negative workplace events.",
+ "PMID": "39586677",
+ "Title": "Journal of child psychology and psychiatry, and allied disciplines",
+ "ArticleTitle": "Editorial Perspective: A systems approach to addressing young people's mental health.",
+ "Abstract": "This editorial explores how adopting a social determinants and systemic perspective can enhance preventative measures to boost the mental health of young people. It argues that to effectively elevate the mental health of young people, it is essential to tackle both the overarching influences and their specific local impacts. We maintain that a strategy combining systems thinking with evidence tailored to the local environment and participatory design is essential.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Resilience, Psychological",
- "Cross-Sectional Studies",
- "Female",
- "Adult",
- "Male",
- "Workplace Violence",
- "Burnout, Professional",
+ "Adolescent",
"Mental Health",
- "Middle Aged",
- "Surveys and Questionnaires",
- "Nursing Staff, Hospital",
- "Taiwan"
- ]
+ "Social Determinants of Health",
+ "Mental Disorders",
+ "Child"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "26"
+ }
},
{
- "PMID": "39710755",
- "Title": "Journal of health, population, and nutrition",
- "ArticleTitle": "Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study.",
- "Abstract": "We examined the socio-economic impact, quality of life, and psychological distress among patients affected by DR TB in Romania. The results of this study suggest that social and psychological support will ensure a better standard of living during and following TB treatment.",
+ "PMID": "39578362",
+ "Title": "The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease",
+ "ArticleTitle": "A comprehensive person-centred TB care model, from malnutrition to mental health.",
+ "Abstract": "In recent years, research on TB multimorbidity has increasingly focused on integrated care delivery, particularly concerning common mental disorders (CMDs). Engagement with relevant stakeholders, including service users and providers, has highlighted the critical intersection of TB and CMD, which affects a substantial percentage of individuals. Studies have found that depression affects approximately 45% of TB patients, and anxiety affects around 40%. Moreover, there is a significant evidence and service gap in delivering CMD care, which emphasises the need for a comprehensive approach to address the dual burden of these health challenges.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Quality of Life",
- "Romania",
- "Male",
- "Female",
- "Prospective Studies",
- "Tuberculosis, Multidrug-Resistant",
- "Middle Aged",
- "Adult",
+ "Mental Disorders",
+ "Malnutrition",
+ "Patient-Centered Care",
+ "Tuberculosis",
"Mental Health",
- "Social Class",
- "Socioeconomic Factors",
- "Surveys and Questionnaires",
- "Aged",
- "Cohort Studies",
- "Longitudinal Studies",
- "Psychological Well-Being"
- ]
+ "Depression",
+ "Delivery of Health Care, Integrated",
+ "Anxiety",
+ "Multimorbidity"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "23"
+ }
},
{
- "PMID": "39710684",
- "Title": "BMC women's health",
- "ArticleTitle": "Associations between mental health conditions in pregnancy and maternal socioeconomic status: a population-based retrospective cohort study in Ontario, Canada.",
- "Abstract": "Despite a universal healthcare system, the variations in mental health prevalence and risk during pregnancy based on SES suggest health inequity in Ontario, Canada. Future studies are needed to examine the mechanisms of this health inequity to guide policy makers in reducing disparities in Ontario.",
+ "PMID": "39550645",
+ "Title": "Recenti progressi in medicina",
+ "ArticleTitle": "[Climate crisis and mental health.].",
+ "Abstract": "Climate change has negative effects on mental health as shown by the World health organization (Who). Heatwaves can exacerbate some mental conditions such as schizophrenia and psychosis, both in the elderly and children as well as in young adults, and increase mortality for neurological and psychiatric diseases. Subjects facing climate events such as heavy rains and flooding may suffer from a psychological problem in the short, medium and long-term. Studies from the international and Italian context show that air pollution exposure may affect common mental problems such as depression and anxiety. Taking into account the growing trend in climate extremes, there is the need to deepen the knowledge on this topic to support the implementation of prevention and mitigation interventions.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
- "Ontario",
- "Pregnancy",
- "Retrospective Studies",
+ "Climate Change",
+ "Mental Disorders",
+ "Mental Health",
+ "Air Pollution",
+ "Child",
+ "Aged",
+ "Young Adult",
"Adult",
- "Social Class",
- "Pregnancy Complications",
- "Anxiety",
"Depression",
- "Young Adult",
- "Residence Characteristics",
+ "Italy",
+ "Floods",
+ "World Health Organization"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "17"
+ }
+ },
+ {
+ "PMID": "39547725",
+ "Title": "Critical care clinics",
+ "ArticleTitle": "Post-Intensive Care Syndrome-Mental Health.",
+ "Abstract": "Intensive care unit (ICU) survivors experience longstanding psychological impairments that persist in the months to years following ICU discharge, regardless of severity of illness or extent of physical recovery. Risk factors for psychological problems following critical illness have been identified including early symptoms of acute stress. Assessment of psychological symptoms in ICU patients and survivors remains inconsistent and many do not receive appropriate psychological evaluation, diagnosis, or treatment. Screening patients for psychological impairments early and serially following hospitalization is crucial to addressing patients' needs and mitigating long-term distress, as is connecting patients to outpatient mental health follow-up for treatment.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Critical Illness",
+ "Survivors",
+ "Intensive Care Units",
+ "Critical Care",
"Mental Health",
- "Cohort Studies",
- "Educational Status",
- "Mental Disorders",
- "Income"
- ]
+ "Risk Factors",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "16"
+ }
},
{
- "PMID": "39710634",
- "Title": "BMC women's health",
- "ArticleTitle": "The pandemic within a pandemic: mental health and wellbeing of racially Minoritised women experiencing domestic abuse during the COVID-19 pandemic in the UK.",
- "Abstract": "Implications such as incorporating culturally competent mental health support, exploring the complex and multiple underpinnings of mental health in racially Minoritised victim-survivors of domestic abuse for future pandemic preparedness and support provision are discussed.",
+ "PMID": "39547010",
+ "Title": "Current opinion in psychology",
+ "ArticleTitle": "Meta-nudging and mental health: Using social influencers to change opinions and behaviors that positively impact mental health.",
+ "Abstract": "A central challenge in mental healthcare is effectively disseminating accurate, evidence-based information to encourage behaviors that improve well-being. Nudges, though widely used, often yield small, short-lived effects in changing behaviors. An alternative approach, meta-nudging, uses social influencers to indirectly change beliefs and behaviors by shifting norms within a social group. Meta-nudging may hold promise as a less paternalistic and longer lasting method for promoting positive mental health behaviors. Though, the use of social influencers raises ethical considerations and measurement challenges. Future research should explore AI-generated influencers to enhance personalization and efficacy in promoting mental health.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Female",
- "United Kingdom",
- "Adult",
- "Cross-Sectional Studies",
"Mental Health",
- "Domestic Violence",
- "Middle Aged",
- "Social Support",
- "Resilience, Psychological",
- "Pandemics",
- "Young Adult",
- "Surveys and Questionnaires"
- ]
+ "Health Behavior",
+ "Health Promotion"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "16"
+ }
},
{
- "PMID": "39710627",
- "Title": "International journal of mental health nursing",
- "ArticleTitle": "The Effects of Universal Educational Interventions in Improving Mental Health Literacy, Depression, and Anxiety Among Adolescents: A Systematic Review and Meta-Analysis.",
- "Abstract": "Adolescents are susceptible to developing depression and anxiety, and educational interventions could improve their mental well-being. This systematic review aimed to evaluate the effectiveness of universal educational prevention interventions in improving mental health literacy, depression, and anxiety among adolescents. Eight electronic databases were searched until June 2024: Cochrane Library, PubMed, EMBASE, CINAHL, PsycINFO, Scopus, Web of Science, ProQuest Dissertations, and Theses Global. Since the included studies assessed various aspects of mental health literacy, the results for mental health literacy were synthesized narratively. In contrast, a meta-analysis using a random-effects model was applied to the depression and anxiety outcomes. Heterogeneity was examined using I",
+ "PMID": "39545535",
+ "Title": "Revue medicale de Liege",
+ "ArticleTitle": "[Health is a serious matter : so let's play ! Part 2 : an overview of \u00abserious gaming\u00bb in mental health].",
+ "Abstract": "In a first article we highlighted the importance of serious gaming in physical medicine and in rehabilitation. In this second article on the same topic, we discuss the potential impact of serious gaming in the field of mental health. The technical aspects, advantages and disadvantages, limits and pitfalls are rapidly overviewed in different areas such as addiction, anxiety, autism, depression, schizophrenia, attention disorders, post-traumatic stress syndrome, obsessive compulsive disorders and memory disorders. It is noteworthy that the American Food and Drug Administration awarded its precious label for the very first time to a serious game used for attention-deficit hyperactivity disorder.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Health Literacy",
- "Adolescent",
- "Anxiety",
- "Depression",
+ "Video Games",
+ "Mental Disorders",
"Mental Health",
- "Health Education"
- ]
+ "Behavior, Addictive"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39710497",
- "Title": "Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society",
- "ArticleTitle": "Depression status and risk factors analysis based on the 'individual-social-health system' dimension: evidence from middle-aged and elderly people in China.",
- "Abstract": "The mental health of the middle-aged and elderly population is poor and affected by multidimensional factors. The Chinese government should continue to strengthen its efforts to prevent and treat depression in the middle-aged and elderly population, and establish individualised and comprehensive strategies and measures to enhance the operational effectiveness of the policy.",
+ "PMID": "39541696",
+ "Title": "Journal of health economics",
+ "ArticleTitle": "Universal Credit: Welfare reform and mental health.",
+ "Abstract": "The UK Universal Credit (UC) welfare reform simplified the benefits system whilst strongly incentivising a return to sustainable employment. Exploiting a staggered roll-out, we estimate the differential effect of unemployment under UC versus the former system on mental health. Groups with fewer insurance possibilities - single adults and lone parents - experience a mental health deterioration of 8.4-13.9% standard deviations which persists into the subsequent year. For couples, UC partially or fully mitigates mental health consequences of unemployment. Exploring mechanisms, for single adults and lone parents, reduced benefit income and strict job search requirements dominate any positive welfare effects of the reduced administrative burden of claiming benefits.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
+ "United Kingdom",
+ "Mental Health",
+ "Adult",
"Male",
- "China",
- "Aged",
- "Risk Factors",
+ "Social Welfare",
+ "Female",
+ "Unemployment",
"Middle Aged",
- "Depression",
- "Longitudinal Studies",
- "Health Status",
- "Mental Health",
- "Aged, 80 and over",
- "Rural Population",
- "Logistic Models"
- ]
+ "Single Parent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "15"
+ }
},
{
- "PMID": "39710338",
- "Title": "Contemporary clinical trials",
- "ArticleTitle": "Optimization of a digital health intervention to enhance well-being among adolescent and young adult cancer survivors: Design and methods of the EMPOWER full factorial trial.",
- "Abstract": "Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations and have not been routinely tested in AYA survivors. We are optimizing a web-based positive skills intervention for AYA cancer survivors called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) by: (1) determining which intervention components have the strongest effects on well-being and (2) identifying demographic and individual difference variables that mediate and moderate EMPOWER's efficacy. EMPOWER is a five-session online intervention that teaches behavioral and cognitive skills for increasing psychological well-being. Guided by the Multiphase Optimization Strategy (MOST), we assign two levels (yes, no) to each of five intervention components (positive events, capitalizing, & gratitude; mindfulness; positive reappraisal; personal strengths & goal-setting; acts of kindness), allowing us to evaluate the effects of individual and combined intervention components on positive affect in a full factorial design. Post-treatment AYA cancer survivors (N\u00a0=\u00a0352) are recruited from participating NCI-designated comprehensive cancer centers and randomized to one of 32 experimental conditions. Our primary outcome is positive affect; potential mediating and moderating variables include coping self-efficacy and emotional support, respectively. Upon trial completion, we will have an optimized, digital health intervention to enhance psychological well-being among AYA cancer survivors. EMPOWER will be scalable and primed for a large, multi-site trial among AYAs who would otherwise not have access to supportive care interventions to manage distress and enhance well-being.",
+ "PMID": "39539246",
+ "Title": "Journal of child psychology and psychiatry, and allied disciplines",
+ "ArticleTitle": "Editorial: Adolescent mental health in a rapidly changing world.",
+ "Abstract": "There is substantial evidence that adolescent mental health has deteriorated considerably since the early 2010s across many countries, and much more strongly among girls than boys. This is probably due to a combination of societal changes that strongly influenced the lives of adolescents. The societal changes include the rise of social media and of academic pressure, the COVID-19 pandemic and increasing worries about the future. Moreover, the decreasing trend in adolescent mental health might have resulted into more mental health awareness and a tendency to overinterpret negative psychological experiences as signs of mental health problems. Several suggestions for future research are provided to increase our understanding of the origins of the recent trends in adolescent mental health.",
"Predictions": [
- "Cancer",
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Cancer Survivors",
"Adolescent",
- "Young Adult",
- "Female",
- "Male",
- "Internet-Based Intervention",
- "Mindfulness",
- "Adult",
- "Emotional Regulation",
- "Quality of Life",
+ "COVID-19",
"Mental Health",
- "Depression",
- "Neoplasms",
- "Research Design",
- "Adaptation, Psychological",
- "Digital Health"
- ]
+ "Mental Disorders",
+ "Adolescent Health",
+ "Male",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "14"
+ }
},
{
- "PMID": "39709458",
- "Title": "Trials",
- "ArticleTitle": "Implementation of a parent training intervention (SPARCK) to prevent childhood mental health problems: study protocol for a pragmatic implementation trial in Norwegian municipalities.",
- "Abstract": "ClinicalTrials.gov NCT05800522.\u00a0Registered on 2023.03.23.",
+ "PMID": "39531993",
+ "Title": "Current opinion in psychology",
+ "ArticleTitle": "Effects of personality and gender on nudgeability for mental health-related behaviors.",
+ "Abstract": "Nudges are a cost-effective and scalable tool used to promote certain choices and have been applied across several domains, such as public health and policy and, more recently, mental health-related behaviors. The likelihood of individuals responding to a nudge (\"nudgeability\") is affected by individual traits such as personality and gender. This review synthesizes the effects of personality traits and gender on decision-making and nudgeability. We provide future directions, which consider these effects when evaluating mental health-related nudging. The specific type of nudge and the behavior being nudged may be more important to consider when designing nudges, rather than general trends in how certain personality traits or genders respond to nudges.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Adolescent",
- "Child",
"Humans",
- "Adaptation, Psychological",
- "Child Behavior",
- "Mental Disorders",
+ "Personality",
"Mental Health",
- "Multicenter Studies as Topic",
- "Norway",
- "Parents",
- "Pragmatic Clinical Trials as Topic"
- ]
+ "Health Behavior",
+ "Sex Factors",
+ "Decision Making",
+ "Choice Behavior",
+ "Male",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39709340",
- "Title": "BMC medical research methodology",
- "ArticleTitle": "The analysis and reporting of multiple outcomes in mental health trials: a methodological systematic review.",
- "Abstract": "Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 11th January 2023 (CRD42023382274).",
+ "PMID": "39523706",
+ "Title": "Nursing standard (Royal College of Nursing (Great Britain) : 1987)",
+ "ArticleTitle": "Communication strategies to support people experiencing mental health issues.",
+ "Abstract": "This article explores the use of effective communication for nurses when interacting with people experiencing mental health issues. Emphasis will be on the importance of nurses adopting person-centred communication styles that prioritise empathy, with the aim of developing a therapeutic rapport. The article underscores the role of the nurse in promoting positive mental health outcomes through the use of techniques such as active listening, empathy and validation. The author also details some of the barriers to effective communication and how nurses can address them.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Randomized Controlled Trials as Topic",
- "Mental Health",
- "Research Design",
- "Outcome Assessment, Health Care",
+ "Communication",
"Mental Disorders",
- "Treatment Outcome"
- ]
+ "Nurse-Patient Relations",
+ "Empathy",
+ "United Kingdom",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39709337",
- "Title": "BMC anesthesiology",
- "ArticleTitle": "Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.",
- "Abstract": "Chinese Clinical Trial Registry (ChiCTR2400084940, date of registration: 05/28/2024).",
+ "PMID": "39514486",
+ "Title": "Medical care",
+ "ArticleTitle": "Health and Well-Being: Distinct and Intertwined Concepts.",
+ "Abstract": "The concepts of health and well-being are deeply intertwined and interdependent. Situating both health and well-being within a unified framework is important to ensure their inclusion in the full spectrum of health research and to achieve the crucial task of building a body of basic, translational, and clinical studies to guide the implementation of whole-person health care. This commentary proposes such a framework where an individual's own assessment of their physical, emotional, and spiritual well-being complements objective measures of their physical and psychological function and where social, environmental, economic, educational, and vocational well-being are located within positive determinants of health.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Sufentanil",
- "Male",
- "Cough",
- "Female",
- "Ketamine",
- "Middle Aged",
- "Prospective Studies",
- "Adult",
- "Anesthesia, General",
- "Anesthetics, Intravenous",
+ "Health Status",
"Mental Health",
- "Double-Blind Method"
- ]
+ "Quality of Life",
+ "Spirituality",
+ "Social Determinants of Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
- {
- "PMID": "39709183",
- "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
- "ArticleTitle": "Promoting Women's Mental Health Across the Life Course.",
- "Abstract": "The guest editors for this series describe the importance of a life course perspective to women's mental health and introduce the articles in the issue.",
+ {
+ "PMID": "39511831",
+ "Title": "Journal of occupational and environmental medicine",
+ "ArticleTitle": "Incorporating Lifestyle Medicine Into Occupational Medicine Practice: ACOEM Guidance Statement.",
+ "Abstract": "Lifestyle medicine (LM) utilizes evidence-based therapeutic lifestyle changes to address lifestyle factors that impact health, performance, and injury risk and recovery. By integrating LM principles into clinical care, workplace policies, and programs, along with other evidence-based methods, occupational and environmental medicine clinicians and medical directors can enhance worker health and performance, manage chronic disease, and facilitate faster recovery from injury and illness. This guidance addresses approaches that can be used in the clinic and workplace to address tobacco, substance misuse, nutrition, physical activity, overweight/obesity, sleep, mental well-being, and social connectedness.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
+ "Occupational Medicine",
+ "Life Style",
+ "Occupational Health",
+ "Exercise",
"Mental Health",
- "Women's Health",
- "Health Promotion"
- ]
+ "Substance-Related Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "13"
+ }
},
{
- "PMID": "39709182",
- "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
- "ArticleTitle": "Racial Categorization in Women's Mental Health Research Fails to Meet the Needs of Multiracial, Biracial, and Mixed-Race Women in the United States.",
- "Abstract": "The author challenges women's mental health researchers to critically examine the categories of race available for research participants, surveillance data, and medical records.",
+ "PMID": "39503673",
+ "Title": "Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners",
+ "ArticleTitle": "Holistic Healing: A Multidisciplinary Approach to Addressing Psychosomatic and Mental Health Challenges in a Young Refugee.",
+ "Abstract": "Our hypothetical case study depicts the experience of a newly arrived refugee child, a 10-year-old refugee from war-torn Kyiv, Ukraine. She presented with symptoms of anxiety-related physical complaints following displacement and relocation to the United States. This case study illustrates the care provided by a pediatric nurse practitioner. A multidisciplinary approach was used to address her psychosomatic symptoms, mental health, malnutrition, immunization status, and social integration challenges.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
+ "Refugees",
"Female",
+ "Child",
+ "Holistic Health",
"United States",
- "Women's Health",
- "Racial Groups",
+ "Psychophysiologic Disorders",
+ "Patient Care Team",
+ "Pediatric Nurse Practitioners",
"Mental Health"
- ]
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "6"
+ }
},
{
- "PMID": "39708948",
- "Title": "Chemosphere",
- "ArticleTitle": "Association between chronic ambient heavy metal exposure and mental health in Korean adult patients with asthma and the general population.",
- "Abstract": "This study suggests that exposure to airborne metals significantly increases depressive symptoms and suicidal ideation, especially in individuals with asthma. Additional clinical research is needed to better understand these associations.",
+ "PMID": "39485187",
+ "Title": "The Veterinary record",
+ "ArticleTitle": "Improving vet student wellbeing: isolation and mental health support.",
+ "Abstract": "Isolation from friends on central campuses, exacerbated by poor transport links, and a lack of practical mental health support provided by universities are two areas having a negative impact on vet student wellbeing. Here Pip Sears discusses some of the issues and suggests improvements that could be made.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Asthma",
- "Metals, Heavy",
- "Male",
- "Adult",
- "Female",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Republic of Korea",
"Mental Health",
- "Suicidal Ideation",
- "Environmental Exposure",
- "Air Pollutants",
- "Young Adult",
- "Depression",
- "Aged"
- ]
+ "Social Isolation",
+ "United Kingdom",
+ "Veterinarians",
+ "Students",
+ "Students, Medical",
+ "Universities"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "11",
+ "Day": "1"
+ }
},
{
- "PMID": "39707472",
- "Title": "BMC psychology",
- "ArticleTitle": "Insights into general practitioners' self-care across 38 countries during the pandemic: a cross-sectional study.",
- "Abstract": "GPs have navigated the pandemic uniquely, and despite applying self-care practices they faced some level of impact, hence self-care interventions for healthcare professionals should be regarded as essential rather than optional. A long-term investment in strategies focused on improving GPs' self-care is necessary to increase resilience among GPs and ensure their optimal well-being levels are achieved.",
+ "PMID": "39470259",
+ "Title": "Revista colombiana de obstetricia y ginecologia",
+ "ArticleTitle": "[How to best address the challenges of mental health in medical education?].",
+ "Abstract": "Editorial.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "General Practitioners",
- "Self Care",
- "Cross-Sectional Studies",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Burnout, Professional",
- "Surveys and Questionnaires",
+ "Education, Medical",
"Mental Health",
- "Anxiety",
- "SARS-CoV-2",
- "Pandemics"
- ]
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "29"
+ }
},
{
- "PMID": "39706574",
- "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
- "ArticleTitle": "Strategies to Improve Women's Mental Health Across the Life Course.",
- "Abstract": "The authors describe four important strategies to improve women's mental health during the perinatal period and across the life course.",
+ "PMID": "39462288",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Health status of Hungarian ambulance workers in the COVID-19 era].",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
+ "COVID-19",
+ "Hungary",
+ "Male",
"Female",
+ "Cross-Sectional Studies",
+ "Pandemics",
+ "Health Status",
+ "Adult",
+ "Ambulances",
"Mental Health",
- "Women's Health",
- "Pregnancy",
- "Perinatal Care",
- "Adult"
- ]
+ "Middle Aged",
+ "Surveys and Questionnaires",
+ "SARS-CoV-2",
+ "Coronavirus Infections",
+ "Pneumonia, Viral",
+ "Musculoskeletal Diseases",
+ "Emergency Medical Technicians"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "27"
+ }
},
{
- "PMID": "39706486",
- "Title": "Preventive medicine",
- "ArticleTitle": "Binge drinking and subsequent health and well-being among middle-aged Spanish adults: An outcome-wide analysis.",
- "Abstract": "Our study provides novel insights into the complex and multifaceted relationship of binge drinking with health and well-being. Further research will enhance our understandings of binge drinking and inform culturally appropriate interventions that effectively mitigate its negative consequences.",
+ "PMID": "39448094",
+ "Title": "Primary care",
+ "ArticleTitle": "Positive Parenting Tips for Parents with Teens.",
+ "Abstract": "This article aims to provide an overview of areas impacting adolescent well-being, offering input and sensible parenting tips. The article is structured into 5 key components that are critical in adolescent life including social media use, nutrition and physical activity, discipline, mental health, and sexual health.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
- "Binge Drinking",
- "Male",
- "Middle Aged",
- "Spain",
- "Longitudinal Studies",
- "Health Behavior",
+ "Parenting",
+ "Adolescent",
+ "Parent-Child Relations",
"Mental Health",
- "Health Status",
- "Adult"
- ]
+ "Exercise",
+ "Social Media",
+ "Adolescent Behavior",
+ "Sexual Health",
+ "Parents",
+ "Adolescent Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "25"
+ }
},
{
- "PMID": "39706485",
- "Title": "Journal of affective disorders",
- "ArticleTitle": "Longitudinal analysis of lifetime stressors and depression: Exploring intersectionality and tailoring social support for better mental health in a community population cohort.",
- "Abstract": "By applying an intersectional lens, the present study provides a novel quantitative instrument for documenting the associations of stress and depression in various social identities. The findings of the study suggest more focused intervention programs and strategies for risk reduction should focus on identified characteristics and pay particular attention to the combined effect of lifetime stressors and discovered social identities.",
+ "PMID": "39433386",
+ "Title": "Pediatric clinics of North America",
+ "ArticleTitle": "Epidemiology of Mental Health Challenges in Children and Adolescents.",
+ "Abstract": "In this narrative review, we will discuss current understandings and evidence on child and adolescent mental health including epidemiologic research methods, prevalence rates of mental health difficulties before the coronavirus disease 2019 pandemic, changes in mental health challenges after the pandemic onset, and clinical implications.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Social Support",
- "Male",
- "Female",
- "Longitudinal Studies",
- "Adult",
- "Stress, Psychological",
- "Middle Aged",
- "Depressive Disorder, Major",
+ "Adolescent",
+ "Child",
+ "COVID-19",
+ "Mental Disorders",
"Mental Health",
- "Social Class",
- "Socioeconomic Factors",
- "Young Adult",
- "Aged",
- "Risk Factors",
- "Cohort Studies"
- ]
+ "Prevalence",
+ "SARS-CoV-2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "22"
+ }
},
{
- "PMID": "39706484",
- "Title": "Journal of affective disorders",
- "ArticleTitle": "Mental health during the 2022 Russo-Ukrainian War: A scoping review and unmet needs.",
- "Abstract": "Cohort studies across different phases of the RUW and populations are required to deliver effective clinical and public health interventions, especially to at-risk populations.",
+ "PMID": "39433384",
+ "Title": "Pediatric clinics of North America",
+ "ArticleTitle": "Innovative Approaches to Addressing Pediatric Mental Health: Digital Technologies in Pediatric Primary Care.",
+ "Abstract": "Digital technologies can be used at multiple levels to support the mental health care of children including (1) health system/health care provider level; (2) patient-provider interface; (3) patient-facing consumer applications; and (4) new technology, including artificial intelligence. At each of these levels, these novel technologies may lead to care improvements but also may have risks. This review provides an overview of each of innovations across the digital landscape.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Mental Disorders",
+ "Child",
+ "Primary Health Care",
+ "Digital Technology",
+ "Pediatrics",
+ "Telemedicine",
"Mental Health",
- "Ukraine",
- "Armed Conflicts",
- "Refugees"
- ]
+ "Mental Health Services",
+ "Artificial Intelligence",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "22"
+ }
},
{
- "PMID": "39705174",
- "Title": "AIDS education and prevention : official publication of the International Society for AIDS Education",
- "ArticleTitle": "Conceptualizations of Mental Health Among Young Black Gay, Bisexual, and Other Men (YB-GBMSM) Who Have Sex With Men Who Are Living With HIV.",
- "Abstract": "Young Black gay, bisexual, and other men who have sex with men who are living with HIV are at an increased risk of experiencing poor mental health due to their exposures to intersectional stigma and discrimination, but often do not seek traditional mental health care. We qualitatively explored conceptualizations of mental health through interviews with 40 participants and analyzed our data using a phenomenology-informed approach. Participants conceptualized mental health as having inward-facing (cultivation of a healthy relationship with oneself, maintaining a peaceful state of mind, lack of depressed mood) and outward-facing components (goal-oriented behavior, resilient coping mechanisms). Some participants espoused an internal locus of control over one's mental state, while others focused on structural or environmental factors as key drivers of mental health. Our findings suggest that provider trainings and service integration, consistent with a more holistic conception of mental health, could help providers support well-being among this population.",
+ "PMID": "39428279",
+ "Title": "European urology oncology",
+ "ArticleTitle": "Maintaining Mental Health: Mindfulness Techniques for Clinicians.",
+ "Abstract": "Urologists suffer from one of the highest rates of burnout, with negative effects for both physicians and patients. We share simple mindfulness-based strategies as invaluable tools for improving mental health, regulating physical and emotional responses to stressors, and strengthening resilience.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Adolescent",
- "Adult",
"Humans",
- "Male",
- "Young Adult",
- "Adaptation, Psychological",
- "Black or African American",
- "HIV Infections",
- "Interviews as Topic",
+ "Mindfulness",
+ "Burnout, Professional",
"Mental Health",
- "Qualitative Research",
- "Sexual and Gender Minorities",
- "Social Stigma"
- ]
+ "Physicians"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39704003",
- "Title": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
- "ArticleTitle": "Beyond the boundaries: Transitioning from categorical to dimensional paradigms in mental health diagnostics.",
- "Abstract": "Mental health diagnostics is undergoing a transformation, with a shift away from traditional categorical systems like the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and the International Classification of Diseases, 11th Revision (ICD-11), and toward innovative frameworks like the Hierarchical Taxonomy of Psychopathology (HiTOP) and the Research Domain Criteria (RDoC). These emerging models prioritize dimensional and biobehavioral approaches in order to overcome limitations such as oversimplification, comorbidity and heterogeneity. This editorial explores the challenges of implementing these paradigms, such as the need for empirical validation, interdisciplinary collaboration and clinician training. It highlights the importance of advanced tools, biomarkers and technological integration to improve precision in diagnosis and treatment. Future research directions include creating reliable dimensional assessment methods, conducting longitudinal studies and fostering interdisciplinary networks. By bridging traditional and emerging frameworks, the field can progress toward personalized, biologically informed mental health treatment. This transition necessitates collaboration among researchers, clinicians and policymakers to improve diagnostic accuracy and treatment outcomes for those affected by mental health disorders.",
+ "PMID": "39427291",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Medical students' perceived stress and mental well-being in light of body mass index and eating behavior].",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Mental Disorders",
+ "Students, Medical",
+ "Female",
+ "Body Mass Index",
+ "Male",
+ "Stress, Psychological",
+ "Feeding Behavior",
+ "Adult",
+ "Young Adult",
"Mental Health",
- "Diagnostic and Statistical Manual of Mental Disorders",
- "International Classification of Diseases"
- ]
+ "Hungary",
+ "Self Concept",
+ "Adaptation, Psychological",
+ "Feeding and Eating Disorders",
+ "Surveys and Questionnaires",
+ "Adolescent"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "21"
+ }
},
{
- "PMID": "39703482",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Interventions aiming to improve menstrual, sexual, reproductive, and mental health among out-of-school girls: a systematic review.",
- "Abstract": "This review suggests that programmes can improve OosG's SRMH knowledge, attitudes, and practices and can be delivered in low resource contexts. Effective interventions are needed to support OoSGs, including interventions focusing on SRMH support incorporating elements of cash-transfer, and comprehensive sexual education, and to aid local policy and programming.",
+ "PMID": "39407402",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Unveiling the silent struggle: navigating the labyrinth of mental health for parents of children with life-threatening illnesses in Pakistan.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
- "Adolescent",
+ "Pakistan",
+ "Parents",
+ "Child",
"Mental Health",
- "Reproductive Health",
- "Sexual Behavior",
- "Sexual Health",
- "Menstruation",
- "Health Knowledge, Attitudes, Practice"
- ]
+ "Mental Health Services"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
},
{
- "PMID": "39703180",
- "Title": "Primary health care research & development",
- "ArticleTitle": "Community pharmacist involvement in social prescribing for mental health: a qualitative study.",
- "Abstract": "An inductive iterative approach to thematic analysis produced four superordinate themes: (1) offering choice a non-pharmacological option, (2) supporting pharmacy communities - 'it is an extension of what we do', (3) stakeholder perspectives - pharmacists are very busy and their expertise unknown by some, and (4) potential for pharmacy in primary care.Stakeholders viewed CP as local to and accessible by their community. Pharmacists perceived referral to SP services as part of their current role. General practitioner participants considered pharmacy involvement could reduce their workload and expand the primary healthcare team. Importantly, general practitioners and CP viewed SP as a non-pharmacological alternative to prescribing unnecessary antidepressants and reduce associated adverse effects. All participants voiced concerns about pharmacy dispensing busyness as a potential barrier to involvement and pharmacists requesting mental health training updates.Key findings suggest CP offer a potential alternative to the general practitioner for people with mild to moderate depression and anxiety seeking access to support and health information. However, CP need appropriately commissioned and funded involvement in SP, including backfill for ongoing dispensing, medicines optimization, and mental health first aid training.",
+ "PMID": "39400435",
+ "Title": "Experimental dermatology",
+ "ArticleTitle": "Mental Health, Sleep and General Health Among Individuals With Dermatologic Conditions: A US Population-Based Study Using the National Health and Nutrition Examination Survey (NHANES).",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Qualitative Research",
- "Male",
+ "Nutrition Surveys",
+ "United States",
"Female",
- "Pharmacists",
+ "Male",
+ "Mental Health",
"Adult",
- "England",
"Middle Aged",
- "Focus Groups",
- "Mental Health",
- "Community Pharmacy Services",
- "Depression",
- "Interviews as Topic",
- "Professional Role",
- "Anxiety"
- ]
+ "Skin Diseases",
+ "Sleep",
+ "Aged",
+ "Health Status",
+ "Young Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "14"
+ }
},
{
- "PMID": "39702091",
- "Title": "BMC primary care",
- "ArticleTitle": "Addressing \"what matters most\" to reduce mental health stigma in primary healthcare settings: a qualitative study in Lebanon.",
- "Abstract": "This study identified key domains to understand the factors for WMM in reducing mental health stigma in Lebanon and explored factors that shape the values and priorities of both PWLE and primary healthcare providers.\u00a0The study suggests assessing the effectiveness of anti-stigma interventions that actively engage PWLE in their design and implementation, while exploring the broader applicability of the WMM framework across different cultural and healthcare settings.",
+ "PMID": "39399916",
+ "Title": "The British journal of psychiatry : the journal of mental science",
+ "ArticleTitle": "The problem with mental health awareness.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Lebanon",
- "Primary Health Care",
- "Social Stigma",
- "Qualitative Research",
"Mental Disorders",
- "Male",
- "Female",
- "Attitude of Health Personnel",
- "Health Personnel",
- "Adult",
- "Interviews as Topic",
- "Mental Health"
- ]
+ "Health Knowledge, Attitudes, Practice",
+ "Mental Health",
+ "Awareness"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "14"
+ }
},
{
- "PMID": "39701588",
- "Title": "JMIR research protocols",
- "ArticleTitle": "A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study.",
- "Abstract": "DERR1-10.2196/59372.",
+ "PMID": "39396340",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "Cultural safety and mental health: CBT for south Asian mothers.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Female",
"Humans",
- "Adolescent",
- "COVID-19",
+ "Cognitive Behavioral Therapy",
+ "Depression, Postpartum",
"Mental Health",
- "Female",
- "Male",
- "Mental Health Services",
- "United States",
- "Child",
- "Emotions",
- "Telemedicine",
- "Social Skills",
- "School Mental Health Services"
- ]
+ "Mothers",
+ "South Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "13"
+ }
},
{
- "PMID": "39700572",
- "Title": "Social science & medicine (1982)",
- "ArticleTitle": "Training humans to supplement a machine learning system: The role of guides in a digital mental health intervention.",
- "Abstract": "Machine learning (ML) is increasingly prevalent in mental health care, with contemporary initiatives leveraging these technologies, sometimes in combination with wearable devices, toward novel interventions. This paper investigates the development of one of these systems, using conversation analysis approach to better understand the work of \"guides,\" a form of labor that is involved in the trial's implementation, and how people are trained for this role. Guides are assigned participants with whom they meet one-on-one over the course of the behavioral modification intervention. Guides are described in advance as an easily replaceable component of the trial. While their work appears sophisticated and valuable in ethnographic observation, in training sessions it is described and enacted as a narrow communicative task of adequately resolving participant queries, even when these queries raise questions about environmental factors or the trial protocol. This paper demonstrates how this occurs in guidance training interactions, offering an empirical account of how new forms of human labor that are required by a machine learning driven intervention are constituted in the interactional practice of training-a process that contributes to both the minimization of the new human labor required for ML-based interventions and the conceptualization of digital mental health interventions as neutral, portable, and not contingent on environmental factors. As digital mental health initiatives move from small pilot studies into broader implementation, understanding of the interactional processes by which new human roles are established is key for specifying new kinds of human labor involved in digital health interventions and leveraging these new roles for adapting interventions according to the particular circumstances of diverse participants and patients.",
+ "PMID": "39396337",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "Unhealthy influencers? Social media and youth mental health.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Adolescent",
"Humans",
- "Machine Learning",
"Mental Health",
- "Adult",
- "Female"
- ]
+ "Social Media"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "13"
+ }
},
{
- "PMID": "39700155",
- "Title": "PloS one",
- "ArticleTitle": "Exploring the gender gap in young adult mental health during COVID-19: Evidence from the UK.",
- "Abstract": "Although across all ages and genders, mental health had returned to near pre-pandemic levels by September 2021, young people and especially women continue to have worse mental health compared to other age groups, which is consistent with pre-COVID age and gender inequalities. Loneliness is a key driver in gendered mental health inequalities during the pandemic in a young adult population.",
+ "PMID": "39382028",
+ "Title": "Journal of the International AIDS Society",
+ "ArticleTitle": "Opportunities for building lifelong resilience and improving mental health for adolescents living with HIV.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Female",
- "Male",
- "Mental Health",
- "United Kingdom",
+ "HIV Infections",
"Adolescent",
- "Young Adult",
- "Loneliness",
- "Adult",
- "Sex Factors",
- "Pandemics",
- "SARS-CoV-2",
- "Longitudinal Studies",
- "Aged",
- "Middle Aged"
- ]
+ "Resilience, Psychological",
+ "Mental Health",
+ "Male",
+ "Female"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "9"
+ }
},
{
- "PMID": "39699982",
- "Title": "Annali dell'Istituto superiore di sanita",
- "ArticleTitle": "Pandemic impact on training and mental health of medical residents: an Italian multicentre prospective study.",
- "Abstract": "Residents reported a relevant frequency of mental issues. Many work-related changes were associated with poor mental health.",
+ "PMID": "39379028",
+ "Title": "Singapore medical journal",
+ "ArticleTitle": "Stigma and mental health: overcoming barriers.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Italy",
- "Prospective Studies",
- "COVID-19",
- "Internship and Residency",
- "Male",
- "Female",
- "Adult",
- "Depression",
- "Anxiety",
+ "Social Stigma",
"Mental Health",
- "Stress Disorders, Post-Traumatic",
- "Pandemics"
- ]
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "9"
+ }
},
{
- "PMID": "39699544",
- "Title": "Revista da Sociedade Brasileira de Medicina Tropical",
- "ArticleTitle": "Chikungunya chronic arthralgia: impact on general and mental health and absenteeism from work.",
- "Abstract": "Chikungunya chronic arthralgia impacts long-term health and work.",
+ "PMID": "39379027",
+ "Title": "Singapore medical journal",
+ "ArticleTitle": "No health without mental health: united we stand.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Absenteeism",
- "Male",
- "Female",
- "Chikungunya Fever",
- "Arthralgia",
- "Middle Aged",
- "Adult",
- "Chronic Disease",
"Mental Health",
- "Cross-Sectional Studies",
- "Depression",
- "Young Adult"
- ]
+ "Mental Disorders",
+ "Singapore"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "9"
+ }
},
{
- "PMID": "39699441",
- "Title": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil",
- "ArticleTitle": "Exploring the complexities and challenges of healthcare access for transgender people in Minas Gerais state: a qualitative study a decade following the implementation of the transsexualization process in the Brazilian National Health System.",
- "Abstract": "Expansion of specialized services and the role of PHC for this population, in order to improve access and care for the transgender population via the Brazilian National Health System in Minas Gerais state.",
+ "PMID": "39375823",
+ "Title": "Musculoskeletal care",
+ "ArticleTitle": "Co-Producing a Package of Novel Online Resources to Support the Mental Health Needs of People With Persistent Pain: BeeFree.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Brazil",
- "Transgender Persons",
- "Health Services Accessibility",
- "Male",
- "Female",
- "Primary Health Care",
- "National Health Programs",
- "Interviews as Topic",
- "Health Personnel",
- "Health Services for Transgender Persons",
- "Qualitative Research",
- "Adult",
- "Health Policy",
- "Mental Health",
- "Transsexualism",
- "Young Adult",
- "Middle Aged"
- ]
+ "Internet",
+ "Chronic Pain",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
},
{
- "PMID": "39699366",
- "Title": "Revista brasileira de enfermagem",
- "ArticleTitle": "Recommendations for guidelines for promoting mental health in the workplace: an umbrella review.",
- "Abstract": "the interventions are based on prevention, promotion and early recognition, support and rehabilitation of mental health problems.",
+ "PMID": "39374959",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Neither seen nor heard: the evidence gap on the effect of covid-19 on mental health in children.",
+ "Abstract": "say better evidence on how children\u2019s mental health is affected by health shocks is essential to inform policy responses",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Workplace",
+ "COVID-19",
+ "Child",
"Mental Health",
- "Health Promotion",
- "Occupational Health",
- "Guidelines as Topic"
- ]
+ "SARS-CoV-2",
+ "Mental Disorders",
+ "Pandemics",
+ "Evidence Gaps"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
},
{
- "PMID": "39697298",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Recovery trajectories of mental health symptoms among Chinese adolescents following the end of COVID-19.",
- "Abstract": "This study is one of the first to reveal the post-pandemic mental health recovery trajectories of Chinese adolescents, highlighting the importance of considering both the number and severity of cumulative mental health problems. The findings offer valuable insights into suicide prevention and the development of targeted interventions to support youth mental health recovery.",
+ "PMID": "39366367",
+ "Title": "Acta medica portuguesa",
+ "ArticleTitle": "Bridging the Gap: Use of Mental Health Apps in the Adolescent Population.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
- "Adolescent",
- "Female",
"Humans",
- "Male",
- "China",
- "COVID-19",
- "East Asian People",
- "Mental Disorders",
- "Mental Health",
- "Risk Factors",
- "Students",
- "Suicidal Ideation",
- "Surveys and Questionnaires"
- ]
+ "Adolescent",
+ "Mobile Applications",
+ "Male",
+ "Mental Health",
+ "Female",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "6"
+ }
},
{
- "PMID": "39697006",
- "Title": "Health promotion international",
- "ArticleTitle": "The influence of access to care on the health literacy of families in Mexico.",
- "Abstract": "Health literacy (HL) is essential to understanding health information and achieving health goals. Unfortunately, limited information is available on how parent HL impact child health outcomes. This is critical to understand in areas of the world where access to healthcare services is limited or unavailable. Thus, the purpose of this study was to assess the moderating influence of access to care on the relationship between parent HL and child health outcomes in Mexico. Using a geographically stratified convenience sample survey design, we gathered a sample of 373 parent-child dyads throughout Mexico in August of 2021. Using the HLS-Q12, the Warwick-Edinburgh Mental Wellbeing Scale, healthcare access questions developed by Levy and Janke, a single-item self-report overall health measure, and questions about substance use frequency, we found that parent HL was positively associated with youth mental wellbeing and overall health. Limited healthcare access was associated with increased youth cigarette, marijuana and alcohol use. Our results indicate that efforts to increase parent HL may be effective in improving youth health behaviors and outcomes.",
+ "PMID": "39362256",
+ "Title": "The Lancet. Oncology",
+ "ArticleTitle": "Investigating hidden influences on treatment for gastrointestinal stromal tumours with AI: diet, chronic conditions, and mental health - Authors' reply.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Health Services Accessibility",
- "Health Literacy",
- "Mexico",
- "Female",
- "Male",
- "Adolescent",
- "Child",
- "Adult",
- "Surveys and Questionnaires",
- "Parents",
+ "Gastrointestinal Stromal Tumors",
"Mental Health",
- "Middle Aged",
- "Health Behavior"
- ]
+ "Chronic Disease",
+ "Diet",
+ "Gastrointestinal Neoplasms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39696336",
- "Title": "Health research policy and systems",
- "ArticleTitle": "Building a research agenda on preventing and addressing sexual assault and intimate partner violence against trans people: a two-stage priority-setting exercise.",
- "Abstract": "These questions form Canada's first research agenda on SA/IPV against trans people. Together, they reflect the insights of stakeholder groups who have been historically excluded from research priority-setting processes and will guide future and much-needed work on the topic. Actionable information on preventing and addressing SA/IPV against trans persons will help reduce negative outcomes associated with being victimized.",
+ "PMID": "39362255",
+ "Title": "The Lancet. Oncology",
+ "ArticleTitle": "Investigating hidden influences on treatment for gastrointestinal stromal tumours with AI: diet, chronic conditions, and mental health.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Intimate Partner Violence",
- "Female",
- "Sex Offenses",
- "Canada",
- "Male",
- "Transgender Persons",
- "Surveys and Questionnaires",
- "Crime Victims",
- "Research",
- "Stakeholder Participation",
- "Mental Health",
- "Health Priorities"
- ]
+ "Chronic Disease",
+ "Diet",
+ "Gastrointestinal Neoplasms",
+ "Gastrointestinal Stromal Tumors",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
},
{
- "PMID": "39696264",
- "Title": "BMC public health",
- "ArticleTitle": "Unlocking the door to mental wellness: exploring the impact of homeownership on mental health issues.",
- "Abstract": "This study provides robust evidence supporting the positive impact of homeownership on mental health. Promoting affordable homeownership opportunities has the potential to alleviate the mental health burden in the United States.",
+ "PMID": "39361010",
+ "Title": "The primary care companion for CNS disorders",
+ "ArticleTitle": "Age-Friendly Health Systems: The Medical and Mental Health Connection.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Female",
- "Male",
- "Adult",
- "Middle Aged",
- "Adolescent",
- "Young Adult",
- "Ownership",
- "Housing",
- "Behavioral Risk Factor Surveillance System",
- "Aged",
- "United States",
+ "Mental Health Services",
+ "Mental Disorders",
"Mental Health",
- "Prevalence",
- "Depressive Disorder"
- ]
+ "Aged",
+ "Primary Health Care"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39696245",
- "Title": "BMC public health",
- "ArticleTitle": "Assessment of displaced Sudanese school-age children's mental health at Ad-Damar, River Nile, Sudan, 2024: a descriptive cross-sectional study.",
- "Abstract": "The study highlights the urgent need for better mental health support for displaced children, given the high prevalence of mental health issues and inadequate support from schools and families. Future research should include longitudinal studies to evaluate long-term effects and intervention effectiveness. Key steps include improving access to mental health services, fostering supportive educational environments, and enhancing family support systems.",
+ "PMID": "39359031",
+ "Title": "Epidemiology and psychiatric sciences",
+ "ArticleTitle": "The pain and mental health comorbidity.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Sudan",
- "Cross-Sectional Studies",
- "Child",
- "Female",
- "Adolescent",
- "Male",
- "Refugees",
+ "Comorbidity",
+ "Mental Disorders",
+ "Pain",
"Mental Health",
- "Surveys and Questionnaires",
- "Stress Disorders, Post-Traumatic"
- ]
+ "Chronic Pain"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "3"
+ }
},
{
- "PMID": "39696093",
- "Title": "BMC public health",
- "ArticleTitle": "Characterising the activity, lifestyle behaviours and health outcomes of UK university students: an observational cohort study with a focus on gender and ethnicity.",
- "Abstract": "The findings of the current study provide an update on the landscape of UK university students' health and health-related behaviours. Overall, health-related outcomes and behaviours are poor in this population and these data suggest that gender and ethnicity play a role in determining students' health and health-related behaviours. Therefore, these factors should be considered when developing strategies to promote healthy living in the context of higher education.",
+ "PMID": "39354137",
+ "Title": "Nature",
+ "ArticleTitle": "The huge toll of PhDs on mental health: data reveal stark effects.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Male",
- "Female",
+ "Mental Disorders",
+ "Mental Health",
+ "Education, Graduate",
"Students",
- "Universities",
- "United Kingdom",
- "Young Adult",
- "Exercise",
- "Cohort Studies",
- "Life Style",
- "Ethnicity",
- "COVID-19",
- "Health Behavior",
- "Sex Factors",
- "Adult",
- "Adolescent",
- "Body Mass Index",
- "Diet",
- "Mental Health"
- ]
+ "Sweden",
+ "Mental Health Services"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "2"
+ }
},
{
- "PMID": "39695709",
- "Title": "Trials",
- "ArticleTitle": "Strategies to improve recruitment in mental health clinical trials: a scoping review (RE-MIND study).",
- "Abstract": "The key finding was that consideration should be given to a mixed methods approach to recruitment not only to enable wider and more diverse participation in mental health trials but also to realize greater efficiency.",
+ "PMID": "39351034",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Editorial: The role of evidence-based medicine and value-based medicine in clinical practice to enhance mental health.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Patient Selection",
- "Mental Disorders",
+ "Evidence-Based Medicine",
"Mental Health",
- "Randomized Controlled Trials as Topic"
- ]
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "1"
+ }
},
{
- "PMID": "39695633",
- "Title": "BMC medicine",
- "ArticleTitle": "Relationships between neurodivergence status and adverse childhood experiences, and impacts on health, wellbeing, and criminal justice outcomes: findings from a regional household survey study in England.",
- "Abstract": "The combination of being ND and experiencing ACEs could additively increase risks of experiencing poor wellbeing and criminal justice outcomes by a greater extent than expected. Preventing and responding to ACEs in ND populations should be a priority to reduce risks of poor health, wellbeing, and criminal justice outcomes in this population.",
+ "PMID": "39349062",
+ "Title": "BMJ global health",
+ "ArticleTitle": "Unbearable suffering: mental health consequences of the October 2023 Israeli military assault on the Gaza Strip.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
+ "Israel",
+ "Middle East",
+ "Military Personnel",
+ "Mental Health",
+ "Violence",
+ "Stress Disorders, Post-Traumatic",
"Male",
- "Adverse Childhood Experiences",
- "Female",
- "England",
- "Adult",
- "Middle Aged",
- "Adolescent",
- "Young Adult",
- "Criminal Law",
- "Health Status",
- "Surveys and Questionnaires",
- "Aged",
- "Mental Health"
- ]
+ "Warfare"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "1"
+ }
},
{
- "PMID": "39695572",
- "Title": "BMC public health",
- "ArticleTitle": "Effects of active video games on mental health among college students: a systematic review.",
- "Abstract": "https://www.crd.york.ac.uk/prospero , identifier: CRD42024510488.",
+ "PMID": "39332826",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Workplace mental health standard is needed to improve staff wellbeing, say professional groups.",
+ "Abstract": "",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Students",
- "Video Games",
- "Universities",
+ "Workplace",
"Mental Health",
- "Young Adult"
- ]
+ "Occupational Health",
+ "United Kingdom"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "28"
+ }
},
{
- "PMID": "39695547",
- "Title": "BMC public health",
- "ArticleTitle": "The mental health of Chinese military personnel: a cross-sectional epidemiological study.",
- "Abstract": "The prevalence of mental health problems among Chinese military personnel has remained at a relatively low level, but our data still suggest that a significant number of individuals in the Chinese military population are affected by mental health issues. It is crucial for military units, society, and the nation to continuously prioritize the mental well-being of soldiers and provide them with more mental health care services.",
+ "PMID": "39245179",
+ "Title": "Journal of the American Academy of Child and Adolescent Psychiatry",
+ "ArticleTitle": "Dr. Pumariega Replies.",
+ "Abstract": "I have read with great interest the Letter to the Editor by dosReis et\u00a0al. in response to my Editorial on the impact of policy on children's mental health. Though I wholeheartedly agree with the perspectives and recommendations made by the authors, I do have to offer cautionary caveats to their proposals.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Military Personnel",
- "Female",
- "Male",
- "Cross-Sectional Studies",
- "China",
- "Adult",
- "Stress Disorders, Post-Traumatic",
- "COVID-19",
- "Sleep Initiation and Maintenance Disorders",
- "Prevalence",
- "Young Adult",
- "Depression",
- "Anxiety",
- "Mental Health",
- "Middle Aged",
- "Surveys and Questionnaires",
- "Adolescent",
- "East Asian People"
- ]
+ "Child",
+ "Health Policy",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "9"
+ }
},
{
- "PMID": "39695533",
- "Title": "BMC public health",
- "ArticleTitle": "The importance of including a mental health dimension in a multimorbidity indicator: an analysis of Belgian health survey data.",
- "Abstract": "MIs that only take physical conditions into account underestimate their impact on individuals' lives. Including mental ill-health in an MI is key to linking it to health correlates.",
+ "PMID": "39209398",
+ "Title": "Revue de l'infirmiere",
+ "ArticleTitle": "[The educational mental health escape game].",
+ "Abstract": "The educational escape game integrates the codes of serious games into the development of nursing students' skills. Used within the framework of the psychopathological processes teaching unit, this method enables learners to appropriate their knowledge, thanks to the development of pedagogical objectives that blend with the mechanics of the game. The escape game is appreciated by students and encourages their commitment to the course.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Belgium",
- "Male",
- "Female",
- "Multimorbidity",
- "Middle Aged",
- "Adult",
- "Aged",
- "Health Surveys",
- "Mental Disorders",
- "Quality of Life",
- "Young Adult",
+ "Students, Nursing",
+ "Education, Nursing",
"Mental Health",
- "Adolescent",
- "Prevalence"
- ]
+ "Video Games"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39695518",
- "Title": "BMC public health",
- "ArticleTitle": "Relationships between resilience, perceived social support, and mental health in military personnel: a cross-lagged analysis.",
- "Abstract": "The negative and positive dimensions of military mental health can interact with each other. Moreover, enhancing resilience and perceived social support may be a novel perspective for improving the mental health of military personnel.",
+ "PMID": "39198009",
+ "Title": "Journal of public health (Oxford, England)",
+ "ArticleTitle": "Addressing gaps in research on the impact of the Taliban's ban on female education on mental health and quality of life in Afghanistan.",
+ "Abstract": "This article presents a series of constructive critiques and proposes a series of potential solutions to address the identified gaps. These include the utilization of experimental or longitudinal designs and the integration of qualitative data in order to gain a more profound understanding of subjective experiences.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Resilience, Psychological",
- "Military Personnel",
- "Male",
- "Social Support",
- "Adult",
- "Personal Satisfaction",
"Female",
- "Mental Health",
- "Depression",
- "Longitudinal Studies",
- "Young Adult",
- "Surveys and Questionnaires",
- "Cross-Sectional Studies"
- ]
+ "Afghanistan",
+ "Quality of Life",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "31"
+ }
},
{
- "PMID": "39695503",
- "Title": "BMC public health",
- "ArticleTitle": "The relationship between non-communicable disease risk and mental wellbeing in adolescence: a cross-sectional study utilising objective measures in Indonesia.",
- "Abstract": "Our analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.",
+ "PMID": "39155348",
+ "Title": "Child and adolescent mental health",
+ "ArticleTitle": "Editorial: Open science and methods review for Child and Adolescent Mental Health.",
+ "Abstract": "This editorial introduces the journal's new open data policy for original articles using quantitative data. It discusses key opportunities from data and code sharing. It further briefly sets out the new methods review that articles which use quantitative analysis will automatically undergo. With both changes we hope to strengthen our review process and contribute to a better evidence base in the field.",
"Predictions": [
- "Noncommunicable Diseases",
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Indonesia",
+ "Child",
"Adolescent",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Cross-Sectional Studies",
- "Risk Factors",
"Mental Health",
- "Quality of Life",
- "Prevalence"
- ]
+ "Periodicals as Topic",
+ "Editorial Policies",
+ "Information Dissemination"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "19"
+ }
},
{
- "PMID": "39695274",
- "Title": "Scientific reports",
- "ArticleTitle": "Media dependency, platform-swinging, and psychological depression among young college students in the polymedia environment.",
- "Abstract": "As a comprehensive and affordable environment, polymedia lays the groundwork for exploring platform-swinging and offers a theoretical framework for investigating its dynamics. Platform-swinging and its unique niche characteristics provide a novel lens to examine the interplay between media dependency and psychological well-being. Using a survey questionnaire, this study collected data from 1210 university students in the Yangtze River Delta, China's most economically developed region, to examine the relationship between media dependency, platform-swinging, and psychological depression. Our findings suggest that the affordances of platform-swinging influence media dependency, whereas the nature of media dependency shapes psychological depression. This study contributes to a deeper understanding of how young adults navigate various media platforms and sheds light on the complex interrelations between media use and mental health. Focusing on platform-swinging in the environment of polymedia explores the relationship between media dependency, platform-swinging, and psychological depression. Moreover, it also compensates for the one-sided understanding caused by simply examining media dependency and psychological depression. This study has practical value and theoretical significance for the psychological health of college students and the research and development of the media dependency theory.",
+ "PMID": "39106833",
+ "Title": "Current biology : CB",
+ "ArticleTitle": "Mental health: The REM sleep paradox in depression.",
+ "Abstract": "The relationship between mental disorders and sleep remains unclear. Two new studies show that the lateral habenula, a brain region associated with value-guided behavior, controls REM sleep and promotes emotional stability but also contributes to REM sleep disinhibition in depression.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Sleep, REM",
"Humans",
- "Students",
- "Female",
- "Male",
- "Young Adult",
"Depression",
- "Universities",
- "China",
- "Surveys and Questionnaires",
- "Mental Health",
- "Adolescent",
- "Adult"
- ]
+ "Animals",
+ "Habenula",
+ "Mental Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "7"
+ }
},
{
- "PMID": "39693620",
- "Title": "Journal of medical Internet research",
- "ArticleTitle": "When and Why Adults Abandon Lifestyle Behavior and Mental Health Mobile Apps: Scoping Review.",
- "Abstract": "This study highlights the complex nature of health app abandonment and the need for an improved understanding of user engagement over time, underscoring the importance of addressing various factors contributing to abandonment, from technical issues to evolving user needs. Our findings also emphasize the need for longitudinal studies and a consistent definition of app abandonment to better understand and mitigate this phenomenon, thereby enhancing the effectiveness of health apps in supporting public health initiatives.",
+ "PMID": "39069940",
+ "Title": "Journal of health care for the poor and underserved",
+ "ArticleTitle": "Amplifying Youth Voice to Promote Black Youth Mental Health Through Policy in Georgia.",
+ "Abstract": "There is an unmet need for mental health policies that are culturally competent, engaging, and equitable for Black youth. This paper describes a youth-adult partnership advisory council approach to identify, assess, and measure the effectiveness of innovative policy solutions to promote Black youth mental health in Georgia.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Mobile Applications",
- "Adult",
+ "Georgia",
+ "Adolescent",
+ "Black or African American",
"Mental Health",
- "Health Behavior",
- "Life Style",
- "Exercise",
- "Telemedicine"
- ]
+ "Health Policy",
+ "Health Promotion",
+ "Young Adult",
+ "Mental Health Services",
+ "Advisory Committees"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "29"
+ }
},
{
- "PMID": "39693599",
- "Title": "The Journal of nervous and mental disease",
- "ArticleTitle": "Well-Being and Mental Health: Where Do We Stand After COVID-19 Pandemic?",
- "Abstract": "Mental health encompasses the ability to cope with important stresses of life and to realize one's abilities in the community, and the COVID-19 pandemic represented a very stressful event for people with mental illnesses. Our aim was to assess mental well-being in people living with different mental disorders, comparing results obtained in 2016 with those observed after the COVID-19 pandemic. Ninety-six participants were assessed using the Mental Health Continuum Short Form and classified as \"flourishing,\" \"moderately mentally healthy,\" and \"languishing.\" Overall, a significant increase in the prevalence of \"flourishing\" and \"moderately mentally healthy\" subjects and a reduction of \"languishing\" subjects ( p = 0.003) were observed. However, a significant improvement in well-being ( p = 0.005) was observed only in the schizophrenia spectrum disorder group. Moreover, only subjects that never contracted SARS-CoV-2 showed a significant ( p = 0.019) increase in positive well-being states. Lockdowns may have led caregivers to spend more time with the participants, also increasing treatment adherence, resulting in an improvement of overall well-being in several participants.",
+ "PMID": "39041870",
+ "Title": "NEJM evidence",
+ "ArticleTitle": "Sleep Health.",
+ "Abstract": "AbstractSleep is what we spend (or should spend) one third of our lives doing. Unfortunately, many individuals fall short of their biological need for sleep many nights of the week. The reasons for this are varied and include professional or personal obligations and social determinants, including loud noises or safety concerns in one's neighborhood. This article reviews the architecture of sleep; evidence for sleep health, including impacts of sleep health on mental and emotional health as well as cognitive function and performance; and strategies for improving sleep health.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "COVID-19",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
+ "Sleep",
"Mental Health",
- "Mental Disorders",
- "Aged",
- "Schizophrenia",
- "SARS-CoV-2"
- ]
+ "Cognition",
+ "Sleep Wake Disorders",
+ "Sleep Quality"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "23"
+ }
},
{
- "PMID": "39691047",
- "Title": "Healthcare quarterly (Toronto, Ont.)",
- "ArticleTitle": "Beyond Traditional Practices: Innovating Workplace Mental Health in the Community.",
- "Abstract": "Workplace mental health is a critical concern. Forty per cent of healthcare workers experience burnout, half intend to leave the profession and only 60% express satisfaction with the quality of care they provide. These statistics highlight the urgency for innovative and holistic approaches to support well-being within healthcare organizations. This article focuses on an organization that prioritizes the mental health of its 8,000 distributed staff. Guided by the values of love, life care and work with purpose, the organization implemented strategies to strengthen its culture, develop leadership and create supportive environments. Emphasis was placed on interventions to mitigate stress and fatigue. Successes and lessons learned are shared, offering a blueprint for other organizations.",
+ "PMID": "38901906",
+ "Title": "Revue de l'infirmiere",
+ "ArticleTitle": "[Nutrition and mental health in athletes].",
+ "Abstract": "In the world of top-level sport, optimising athletic performance does not rely solely on physical training. Taking into account the intestine-brain axis offers new ways of optimising sports preparation, partly thanks to the role of the intestinal microbiota on performance and well-being.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Workplace",
- "Burnout, Professional",
+ "Athletes",
"Mental Health",
- "Organizational Culture",
- "Leadership",
- "Health Personnel",
- "Job Satisfaction",
- "Ontario"
- ]
+ "Gastrointestinal Microbiome",
+ "Sports",
+ "Nutritional Status",
+ "Athletic Performance",
+ "Sports Nutritional Physiological Phenomena"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "21"
+ }
},
{
- "PMID": "39691046",
- "Title": "Healthcare quarterly (Toronto, Ont.)",
- "ArticleTitle": "Promoting Psychological Health and Safety in Canadian Healthcare Organizations.",
- "Abstract": "This article analyzes findings from the Health Standards Organization's new Global Workforce Survey (GWS). The GWS enables healthcare organizations to measure, analyze and benchmark their workforce's perceptions of working conditions, safety culture and care quality against peers. The GWS measures key features of The National Standard of Canada for Psychological Health and Safety in the Workplace (CSA Group and Bureau de normalisation du Qu\u00e9bec 2013; MHCC 2013). The article highlights how psychological health and safety in Canadian healthcare organizations can enhance the well-being of workers, improve patient care and ultimately contribute to a more effective healthcare system.",
+ "PMID": "38823813",
+ "Title": "Child and adolescent psychiatric clinics of North America",
+ "ArticleTitle": "Mobilizing Meaning: Religion and Spirituality Among Future Generations.",
+ "Abstract": "Religion and spirituality have long been known to impact both physical and mental health. Considering religion and spirituality as possible additions to social determinants of health, this article examines the current state of religion and spirituality in the United States and also discusses the ways in which they can contribute to the mental health of children and adolescents. Further, this article also discusses new approaches within religion and spirituality to address the changing needs of future generations.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Canada",
+ "Spirituality",
+ "Child",
+ "Adolescent",
+ "United States",
"Mental Health",
- "Occupational Health",
- "Workplace",
- "Health Personnel",
- "Organizational Culture",
- "Surveys and Questionnaires",
- "Patient Safety",
- "Safety Management"
- ]
+ "Religion and Psychology",
+ "Religion"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "2"
+ }
},
{
- "PMID": "39691045",
- "Title": "Healthcare quarterly (Toronto, Ont.)",
- "ArticleTitle": "Introduction to Mental Health in Healthcare Workplaces.",
- "Abstract": "In the quest by health leaders to create the conditions necessary for the delivery of safe, high-quality care, this issue of ",
+ "PMID": "38796245",
+ "Title": "Revue de l'infirmiere",
+ "ArticleTitle": "[Initiation to patient partnership in mental health and psychiatry from initial training onwards].",
+ "Abstract": "Introducing patient partnership in mental health and psychiatry to initial training is an innovative way of promoting recovery, while at the same time highlighting the undeniable contribution of peer support within healthcare teams, in order to accompany the people concerned. This is why Croix-Rouge Comp\u00e9tence Auvergne-Rh\u00f4ne-Alpes is developing a specific training program for trainees.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Workplace",
- "Health Personnel",
+ "Psychiatry",
+ "Mental Disorders",
"Mental Health",
- "Occupational Health"
- ]
+ "Patient Participation",
+ "France",
+ "Psychiatric Nursing"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "26"
+ }
},
{
- "PMID": "39690437",
- "Title": "Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals",
- "ArticleTitle": "Associations Between Food Security, Housing and Health in South Australia.",
- "Abstract": "Food security is itself a determinant of health. Regular monitoring of the\u00a0prevalence of household food insecurity and addressing the structural factors influencing food affordability and availability are required. Further research on its links to health outcomes is warranted. SO WHAT?: Evidence-based action to address food insecurity will become more pressing as the crises of cost-of-living, housing, health system pressures and environmental disasters converge.",
+ "PMID": "38572981",
+ "Title": "International journal of mental health nursing",
+ "ArticleTitle": "The weather as a determinant of farmer's mental health: A dependent, interacting, cumulative and escalating model (DICE) of the effects of extreme weather events.",
+ "Abstract": "This perspective paper presents a conceptual, theoretical framework of the weather as a determinant of mental health for farmers. This model proposes that the effects of extreme weather events have interacting and cumulative effects for farmers, who are dependent on the land.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "South Australia",
- "Housing",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Food Security",
- "Health Status",
+ "Farmers",
"Mental Health",
- "Health Surveys",
- "Socioeconomic Factors",
- "Adolescent",
- "Food Insecurity",
- "Aged",
- "Chronic Disease",
- "Young Adult",
- "Food Supply"
- ]
+ "Extreme Weather",
+ "Weather",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "4"
+ }
},
{
- "PMID": "39690123",
- "Title": "Journal of child psychology and psychiatry, and allied disciplines",
- "ArticleTitle": "Editorial: From adolescence into young adulthood - the importance of a longitudinal perspective across development in child and adolescent mental health.",
- "Abstract": "The transition from adolescence into adulthood is a pivotal phase in a person's life, marking a period of significant social, psychological, and biological changes that can profoundly impact an individual's well-being and developmental trajectory. During this period, adolescents and young adults face increasing environmental demands from academic or occupational responsibilities and social interactions, including the pursuit of romantic partners. These changes are inherently related to stress, which is essential for adolescents and young adults to develop their personality and form an identity. Throughout adolescence into young adulthood, the brain undergoes maturational changes as part of the normal development, and it is possible that deviations from the expected developmental trajectories may contribute to the onset of psychiatric disorders in this age group. This editorial highlights recent work published in the Journal of Child Psychology and Psychiatry that examines important aspects of this developmental period.",
+ "PMID": "38572709",
+ "Title": "Assistenza infermieristica e ricerca : AIR",
+ "ArticleTitle": "[Mental health worldwide: commentary on the WHO 2022 Report].",
+ "Abstract": "We report in this issue a contribution by Benedetto Saraceno, published in Salute Internazionale (https://www.saluteinternazionale.info), commenting on the WHO 2022 report on mental health in the world. The comment highlights the progresses but also the presence, beyond declarations of principle, of large psychiatric institutions. There is still a long way to go to defend the rights of people with psychiatric problems.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
"Humans",
- "Adolescent",
- "Adolescent Development",
- "Young Adult",
- "Adult",
- "Child",
- "Mental Health"
- ]
+ "Mental Health",
+ "World Health Organization",
+ "Mental Disorders"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "4"
+ }
},
{
- "PMID": "39690113",
- "Title": "Salud colectiva",
- "ArticleTitle": "[Racism and mental health in indigenous youth living in the Metropolitan Area of Oaxaca, Mexico].",
- "Abstract": "Indigenous populations show high prevalence rates of mental disorders and limited access to mental health services. The aim of this study was to analyze the mental health care trajectories of indigenous youth living in the Metropolitan Area of Oaxaca, Mexico. Between May and August 2023, we conducted a qualitative study involving non-participant observation, in-depth interviews with seven indigenous youth, and semi-structured interviews with nine health professionals, healers, or leaders of mutual support groups. We identified processes, not exempt of tensions, in how these young people perceive themselves as both young and indigenous, in the development of their mental disorders, and in the ways they seek treatment. Their care involved the use of psychological and psychiatric services, mutual support groups, and, to a limited extent, traditional medicine. This study concludes that these dynamics are interwoven and amplified by interpersonal, institutional and epistemic racism, which must be dismantled to improve the mental health of indigenous youth.",
+ "PMID": "38557095",
+ "Title": "British journal of hospital medicine (London, England : 2005)",
+ "ArticleTitle": "A picture of health? The quality of physical healthcare provided to adult patients admitted to a mental health inpatient setting.",
+ "Abstract": "The National Confidential Enquiry into Patient Outcome and Death reviewed the quality of physical healthcare provided to adults admitted to a mental health inpatient setting, highlighting areas of practice that need improving and making recommendations for clinical and organisational changes that will improve patient care.",
"Predictions": [
"Mental Health"
],
"MeshTerms": [
+ "Adult",
"Humans",
- "Mexico",
- "Adolescent",
- "Male",
- "Female",
- "Racism",
- "Mental Disorders",
- "Qualitative Research",
+ "Inpatients",
"Mental Health",
- "Mental Health Services",
- "Young Adult",
- "Interviews as Topic",
- "Health Services Accessibility",
- "Urban Population",
- "Urban Health",
- "Indigenous Peoples",
- "Patient Acceptance of Health Care"
- ]
+ "Delivery of Health Care",
+ "Hospitalization"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "1"
+ }
}
]
\ No newline at end of file
diff --git a/testModel/dataset/non-communicable_diseases.json b/testModel/dataset/non-communicable_diseases.json
new file mode 100644
index 000000000..ddcdd3b97
--- /dev/null
+++ b/testModel/dataset/non-communicable_diseases.json
@@ -0,0 +1,2391 @@
+[
+ {
+ "PMID": "39737510",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "Prevalence of risk factors of non-communicable diseases among adults in urban slums of Burdwan municipality, West Bengal: A cross sectional study.",
+ "Abstract": "Background & objectives Non communicable diseases (NCD) have emerged as one of the leading causes of mortality and morbidity in India in the past few decades. This study was undertaken to determine the prevalence of NCD risk factors among adults residing in urban slums of West Bengal, India. Methods A community based cross-sectional study was conducted among adult population aged 15-69 yr in urban slums of Purba Burdwan district, West Bengal over a period of two months. A total of with 180 study participants selected by simple random sampling. Data were collected using a semi-structured schedule, adopted from the WHO STEPS questionnaire. Analysis was done using Chi-square test and logistic analysis. P<0.05 was considered to be significant. Results The prevalence of alcohol intake, smoking, inadequate vegetable and fruit intake, reduced physical activity and overweight and/or obesity was 27.8, 15.6 , 93.3 , 32.8 and 15.5 per cent, respectively among the study population. A significant association of smoking was found among males [Adjusted odds ratio (AOR) 2.54 Confidence interval (CI):1.76-6.99], those living in joint families (AOR 1.24 CI:1.17-1.34) and without any formal education (AOR 3.22 CI:1.50-13.87). The odds of alcohol consumption alcohol, were higher among those aged >44 yr (AOR 1.98 CI:1.34-7.22), males (AOR 2.65 CI:1.89-8.76), those who had no formal education (AOR 1.43 CI:1.23-2.77) and those who were employed (AOR 1.34 CI:1.02-4.09). Again respondents aged 45-69 yr (AOR 4.45 CI:1.79-10.99) and married (AOR 3.77 CI:1.76-7.44) were associated with overweight and or/obesity. Furthermore, age AOR 5.04 CI:1.34-17.98) and employment status (AOR 1.78 CI:1.67-3.09) were significantly associated with raised blood pressure in multivariate analysis. Interpretation & conclusions The high prevalence of risk factors of NCD in the study population is suggestive of a need for health promotion by creating awareness about the dangers of smoking and alcohol consumption as well as educating the people about the benefits of physical activity and eating a healthy diet.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adult",
+ "Middle Aged",
+ "India",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Aged",
+ "Poverty Areas",
+ "Adolescent",
+ "Prevalence",
+ "Smoking",
+ "Alcohol Drinking",
+ "Obesity",
+ "Cross-Sectional Studies",
+ "Young Adult",
+ "Urban Population"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39737504",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "Stem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.",
+ "Abstract": "Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy. Results Of the 9206 studies screened, 61 studies that were relevant to stem cell use for non-malignant diseases were included for analysis. Autologous stem cells (75%) were used predominantly compared to allogenic stem cells (18.33%), followed by mixed type (6.67%). Use of bone marrow-derived stem cells (51%) was dominant, followed by melanocytes (19%), adipose (7%), haematopoietic (12%), and (11%) other types of stem cells. The study revealed 37 randomized clinical trial studies conducted in the government research hospital compared to the non-government. Interpretation & conclusions Maintaining the gold standard for stem cell therapy requires randomized clinical trials with large sample sizes, control groups, failures, adverse effects, etc. It is important to have a monitoring and regulation system in stem cell clinical research activities with enough preclinical data and repeated exchanges between the bench and the bedside.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Stem Cell Transplantation",
+ "Cell- and Tissue-Based Therapy",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39736607",
+ "Title": "International journal for equity in health",
+ "ArticleTitle": "Social and economic impacts of non-communicable diseases by gender and its correlates: a literature review.",
+ "Abstract": "Tackling social impacts derived from gender disparities is a pathway to universal health coverage (UHC). Gender intersects with other factors behind social and health inequalities, exacerbates them and influences health systems' performance. However, there is scarcity of gender-based studies that assess the social and economic impacts of non-communicable diseases (NCDs). This study aims to identify economic and social impacts of NCDs by gender and its correlates.Following the guidelines proposed in the Cochrane Manual for Systematic Reviews of Interventions and the PRISMA Statement, we conducted a narrative and structured literature review to identify the economic (direct medical and non-medical, and indirect costs) and social (right to health, employment, poverty, social exclusion, and others) impacts of NCDs by gender, and its structural, sociodemographic, health conditions, political and health systems correlates, for the period 2002-2022, in English and Spanish. Reviewed studies were described according to country and research context, temporal evolution, gender, impacts of NCDs and correlates.Five thousand five hundred fifty-one publications by title and abstract were reviewed, and 185 articles were selected. There is limited evidence with gender perspective addressing the social and economic impacts of NCDs (around 10% of publications) that helps to better understand the difference in the burden of these conditions between men and women. We identified that the social burden primarily affects women in their quality of life, where gender inequities are observed in aspects such as: health care, employment status and living conditions. In addition, a greater responsibility falls on them as caregivers. On the other hand, the economic burden affects more to men, both in terms of direct medical costs and indirect costs. Among the factors that most influenced the identified impacts, we found gender, age, and socioeconomic level. We also identified that access to health insurance that offers financial protection against these conditions is essential to reduce these impacts.NCDs pose a significant social and economic burden due to their impact on the health of the population, healthcare systems, and the economies of households and nations, which will likely increase over time. This impact is closely related to gender, although it has been scarcely documented. Public policies aimed at enhancing access and achieving UHC are essential to guarantee effective financial protection in health, especially for the most vulnerable sectors of the population.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Sex Factors",
+ "Employment",
+ "Socioeconomic Factors",
+ "Poverty",
+ "Universal Health Insurance",
+ "Cost of Illness"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "31"
+ }
+ },
+ {
+ "PMID": "39732655",
+ "Title": "BMC public health",
+ "ArticleTitle": "Bias in machine learning applications to address non-communicable diseases at a population-level: a scoping review.",
+ "Abstract": "Machine learning (ML) is increasingly used in population and public health to support epidemiological studies, surveillance, and evaluation. Our objective was to conduct a scoping review to identify studies that use ML in population health, with a focus on its use in non-communicable diseases (NCDs). We also examine potential algorithmic biases in model design, training, and implementation, as well as efforts to mitigate these biases.We searched the peer-reviewed, indexed literature using Medline, Embase, Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews, CINAHL, Scopus, ACM Digital Library, Inspec, Web of Science's Science Citation Index, Social Sciences Citation Index, and the Emerging Sources Citation Index, up to March 2022.The search identified 27 310 studies and 65 were included. Study aims were separated into algorithm comparison (n\u2009=\u200913, 20%) or disease modelling for population-health-related outputs (n\u2009=\u200952, 80%). We extracted data on NCD type, data sources, technical approach, possible algorithmic bias, and jurisdiction. Type 2 diabetes was the most studied NCD. The most common use of ML was for risk modeling. Mitigating bias was not extensively addressed, with most methods focused on mitigating sex-related bias.This review examines current applications of ML in NCDs, highlighting potential biases and strategies for mitigation. Future research should focus on communicable diseases and the transferability of ML models in low and middle-income settings. Our findings can guide the development of guidelines for the equitable use of ML to improve population health outcomes.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Machine Learning",
+ "Bias",
+ "Population Health",
+ "Algorithms"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "39732436",
+ "Title": "The Journal of nutrition",
+ "ArticleTitle": "Consumption of Sodium and Its Ratio to Potassium in Relation to All-Cause, Cause-Specific, and Premature Noncommunicable Disease Mortality in Middle-Aged Japanese Adults: A Prospective Cohort Study.",
+ "Abstract": "Reducing premature noncommunicable disease (NCD) mortality is a global challenge. Sodium is thought to increase risk of NCDs via an effect of salt per se or high-salt foods on hypertension-induced cardiovascular disease (CVD) and gastrointestinal cancer. Further, relative risk of CVD is reportedly more closely associated with sodium-to-potassium ratio than that with sodium alone. However, few studies have investigated the effect of consumption of sodium or its ratio to consumption of potassium on risk of premature NCD death.We examined associations between intake of sodium and sodium-to-potassium ratio and risk of all-cause and cause-specific death, including premature NCD, in a Japanese prospective cohort study.During 1995-1998, a validated food frequency questionnaire was administered in 11 areas to 83,048 men and women aged 45-74 y. During 1,587,901 person-years of follow-up until the end of 2018, 17,727 all-cause deaths and 3555 premature NCD deaths were identified.Higher sodium intake was significantly associated with increased risk of all-cause and premature NCD mortality, but not all NCD mortality, among men: multivariate hazards ratios for the highest compared with lowest quintiles (HR) were 1.11 (95% CI: 1.03, 1.20; P-trend < 0.01) for all-cause and 1.25 (95% CI: 1.06, 1.47; P-trend < 0.01) for premature NCD mortality. When intakes were expressed as ratio to potassium intake, these associations (HR of all-cause: 1.19, 95% CI: 1.11-1.27; P-trend < 0.01; HR of premature NCD: 1.27, 95% CI: 1.10, 1.46; P-trend < 0.01), including associations with cancers (HR: 1.18, 95% CI: 1.07, 1.31; P-trend = 0.02), were strengthened in men.This prospective cohort study showed that both sodium intake and sodium-to-potassium ratio are associated with increased risk of all-cause and early NCD mortality in middle-aged men.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Prospective Studies",
+ "Japan",
+ "Aged",
+ "Sodium, Dietary",
+ "Noncommunicable Diseases",
+ "Cohort Studies",
+ "Potassium, Dietary",
+ "Mortality, Premature",
+ "Cause of Death",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Diet",
+ "Potassium",
+ "East Asian People"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "39731009",
+ "Title": "BMC public health",
+ "ArticleTitle": "Investigating the influence of working status changes on physical activity and non-communicable diseases in Korean middle-aged and older adults: insights from a longitudinal panel study.",
+ "Abstract": "Non-communicable diseases (NCDs) are a major global health challenge and occupational status is a critical determinant influencing NCD development, yet many cross-sectional studies have only linked current occupational status with specific diseases, overlooking broader temporal factors. The primary aim of the present study was to comprehensively elucidate the intricate interplay between alterations in working status, NCDs, and physical activity (PA) among Korean middle-aged and older adults, employing a longitudinal panel study design.This study utilized longitudinal data from the Korean Longitudinal Study of Aging, covering the period from 2006 to 2020, with a median follow-up duration of 10 years. (n\u2009=\u20095101 participants aged 45 years and older). Changes in working status were categorized, focusing on (1) yes-yes (e.g., indicative of sustained employment), (2) yes-no (e.g., denoting a transition from employment to non-employment), (3) no-yes (e.g., representing a shift from non-employment to employment), and (4) no-no (reflecting a continual non-employment status). PA was defined as the total minutes of moderate-to-vigorous PA per week and categorized into two groups: <150\u00a0min/week and \u2265\u2009150\u00a0min/week. Confounding factors included age, gender, marital status, education level, and body mass index. Relative risk ratios (RRR) with 95% confidence intervals (CI) were calculated using random-effect multinomial logistic regression.Individuals who were currently employed (adjusted RRR\u2009=\u20090.688, 95% CI\u2009=\u20090.656-0.722, p\u2009<\u20090.001) or who transitioned to employment (adjusted RRR\u2009=\u20090.755, 95% CI\u2009=\u20090.707-0.807, p\u2009<\u20090.001) had a reduced risk of physical inactivity. However, employed individuals had an increased risk of cardiovascular diseases (yes-yes: adjusted RRR\u2009=\u20091.653, 95% CI\u2009=\u20091.547-1.766, p\u2009<\u20090.001; no-yes: adjusted RRR\u2009=\u20091.168, 95% CI\u2009=\u20091.100-1.240, p\u2009<\u20090.001) and diabetes (yes-yes: adjusted RRR\u2009=\u20091.535, 95% CI\u2009=\u20091.464-1.610, p\u2009<\u20090.001; no-yes: adjusted RRR\u2009=\u20091.124, 95% CI\u2009=\u20091.078-1.173, p\u2009<\u20090.001). Additionally, current workers exhibited higher risks of cancer (yes-yes: adjusted RRR\u2009=\u20091.871, 95% CI\u2009=\u20091.721-2.035, p\u2009<\u20090.001; no-yes: adjusted RRR\u2009=\u20091.089, 95% CI\u2009=\u20091.018-1.166, p\u2009=\u20090.014) and chronic respiratory diseases (yes-yes: adjusted RRR\u2009=\u20091.467, 95% CI\u2009=\u20091.307-1.648, p\u2009<\u20090.001; no-yes: adjusted RRR\u2009=\u20091.121, 95% CI\u2009=\u20091.011-1.242, p\u2009=\u20090.029).This longitudinal study revealed that individuals engaged in or transitioning to employment displayed a reduced likelihood of regular PA. Moreover, those with work history, transitioning, or consistently working, exhibited increased vulnerability to all NCDs compared to those without work experience.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Republic of Korea",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Longitudinal Studies",
+ "Noncommunicable Diseases",
+ "Exercise",
+ "Employment",
+ "Aged",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "39725416",
+ "Title": "BMJ open",
+ "ArticleTitle": "How does the level of functional impairment vary in individuals with non-communicable disease and comorbidity? Cross-sectional analysis of linked census and administrative data in Aotearoa New Zealand.",
+ "Abstract": "This study examines national patterns of functional impairment, and how they vary by the presence of non-communicable disease (NCD), type of health condition, comorbidity, age, sex, ethnicity, deprivation and living situation.A cross-sectional examination using a national research database of linked administrative and survey data sets including census, tax and health data.Aotearoa New Zealand PARTICIPANTS: All individuals living in NZ on 30 June 2018, identified by the Statistics NZ Integrated Data Infrastructure estimated residential population (4.79 million individuals). Nine NCDs among these individuals were identified from national health data sets using existing and adapted algorithms.Functional impairment was assessed via hospitalisations, comorbidities (Elixhauser index), activity limitations (census) and income support.Three-tenths (29%) of the population had at least one NCD. Functional impairment was strongly patterned by NCD prevalence (3% activity limitation in people without any NCDs, 13% if one or more NCDs and 25% if two or more NCDs). Activity limitation was most common in individuals with dementia (68% activity limitation), stroke (42%) and coronary heart disease (26%). After age stratification, there was also a high level of activity limitation and income support in people with mental health conditions. M\u0101ori and Pacific peoples and people living in deprived areas or alone were more likely to have functional impairment.Functional impairment was strongly patterned by NCD type. NCD prevention efforts and disability supports are needed to reduce the burden of disability experienced.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "New Zealand",
+ "Cross-Sectional Studies",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Noncommunicable Diseases",
+ "Adult",
+ "Comorbidity",
+ "Censuses",
+ "Adolescent",
+ "Young Adult",
+ "Aged, 80 and over",
+ "Prevalence",
+ "Child",
+ "Child, Preschool"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "39722627",
+ "Title": "Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit",
+ "ArticleTitle": "The impact of health taxes on consumption of tobacco and sugar-sweetened beverages in the Eastern Mediterranean Region.",
+ "Abstract": "Consumption of tobacco, nicotine and sugar-sweetened beverages (SSBs) poses a significant risk to public health, contributing to increases in noncommunicable diseases (NCDs) such as cardiovascular disease, diabetes, cancer, and obesity. Globally, regular consumption of SSBs increases the risk of type 2 diabetes by 26%, and deaths related to tobacco and nicotine consumption exceed 8 million annually, including 1.3 million due to exposure to second-hand smoke. This loss of lives and the negative impact on health underscore the urgent need for effective public health interventions to curb the consumption of these harmful products.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sugar-Sweetened Beverages",
+ "Taxes",
+ "Tobacco Products",
+ "Mediterranean Region",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "39709790",
+ "Title": "Redox biology",
+ "ArticleTitle": "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.",
+ "Abstract": "Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE). The products of these genes participate in numerous functions including biotransformation and redox homeostasis, lipid and iron metabolism, inflammation, proteostasis, as well as mitochondrial dynamics and energetics. Thus, it is possible that a single pharmacological NRF2 modulator might mitigate the effect of the main hallmarks of NCDs, including oxidative, proteostatic, inflammatory and/or metabolic stress. Research on model organisms has provided tremendous knowledge of the molecular mechanisms by which NRF2 affects NCDs pathogenesis. This review is a comprehensive summary of the most commonly used model organisms of NCDs in which NRF2 has been genetically or pharmacologically modulated, paving the way for drug development to combat NCDs. We discuss the validity and use of these models and identify future challenges.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "NF-E2-Related Factor 2",
+ "Humans",
+ "Animals",
+ "Noncommunicable Diseases",
+ "Oxidative Stress",
+ "Reactive Oxygen Species",
+ "Oxidation-Reduction",
+ "Disease Models, Animal",
+ "Inflammation",
+ "Gene Expression Regulation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "23"
+ }
+ },
+ {
+ "PMID": "39702198",
+ "Title": "BMC geriatrics",
+ "ArticleTitle": "Age- and sex-disaggregated disease burden among the older persons in India.",
+ "Abstract": "In the context of the increasing number and proportion of population aged 60\u00a0years or more in India, it is imperative to understand their health needs for ensuring healthy ageing.Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we identified the top ten causes of disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) disaggregated by sex and age groups (60-64 years, 65-69 years, 70-74 years, 75-79 years, and\u2009\u2265\u200980 years) for India in 2019. We analysed the proportional contribution of individual causes to the total DALYs due to communicable diseases (CMNNDs), non-communicable diseases (NCDs), and injuries disaggregated by age and sex. We report the state-level heterogeneity in the crude DALY rate for CMNNDs, NCDs, and injuries for older persons disaggregated by sex. Additionally, we reviewed if the data capture of service delivery indicators on older persons were age- and sex-disaggregated in the Health and Wellness Centres (HWCs), and in the National Programs aimed at the Health Care for the Elderly (NPHCE), Prevention and Control of Non-communicable Diseases (NP-NCD), Control of Blindness and Visual Impairment (NPCBVI), Prevention & Control of Deafness (NPPCD), the Mental Health Program (NMPH), and the AYUSH Musculoskeletal Disorders Program (MSDP) within the context of disease burden.The older persons accounted for a total of 136.1 million DALYs (29.1% of the total DALYs) in 2019 of which 77.9% were from NCDs, 14.8% from CMNNDs, and 7.3% from injuries, and nearly two-thirds of DALYs were accounted by YLLs. In NCDs, cardiovascular diseases, chronic respiratory diseases, neoplasms, diabetes and kidney diseases, and musculoskeletal disorders accounted for nearly 80% of DALYs for both sexes. There were variations in the magnitude of disease burden by specific diseases and conditions between females and males, and by age groups within both sexes particularly for injuries and CMNNDs. Injuries accounted for more YLDs than YLLs, ranging between 5.9%-15.2% for females and 15.3%-17.3% for males, with the females having a higher contribution to total injury related DALYs due to falls as compared to the males (54.4% vs 36.6%), whereas the males had a higher contribution to total DALYs due to road injuries (33.8% vs 19.4%). There was substantial variation in the crude DALY rates of major disease groups by the two sexes across the states of India in 2019. The crude DALY rate for CMNNDs varied between 3.6 times -3.7 times between the states for females and males, respectively; NCDs varied between 1.3 times -1.9 times, and injuries varied 2.0 times -1.7 times. The capture of service utilisation indicators was not age- or sex-disaggregated in NPHCE, NPCBVI, NMHP, MSDP, and HWCs; sex-disaggregation was available in NP-NCD but not age-disaggregation; sex-disaggregated data was available for many service indicators in NPPCD but with no age disaggregation beyond 50\u00a0years and more. Only NP-NCD and NPPCD allowed for data capture by disease/condition or severity of disease/condition for the older persons whereas the other programs including NPHCE did not allow for much disaggregated understanding by the type of services availed.This comprehensive assessment of the differentials in disease burden among older persons across age, sex and states of India, and the gaps identified in the service utilisation data capture by age and sex for the older persons in the national health programs can provide crucial inputs for strengthening the on-going public health policy and programmatic efforts aimed at improving the health and well-being of the growing older population in India.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Female",
+ "Male",
+ "India",
+ "Middle Aged",
+ "Aged, 80 and over",
+ "Noncommunicable Diseases",
+ "Cost of Illness",
+ "Disability-Adjusted Life Years",
+ "Sex Factors",
+ "Age Factors",
+ "Global Burden of Disease",
+ "Wounds and Injuries"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "20"
+ }
+ },
+ {
+ "PMID": "39699459",
+ "Title": "Revista brasileira de epidemiologia = Brazilian journal of epidemiology",
+ "ArticleTitle": "Chronic noncommunicable diseases and absenteeism from work: National Survey of Health, 2019.",
+ "Abstract": "To evaluate the association between burden of disease and multimorbidity and absenteeism in Brazil.This is a cross-sectional study using data from the National Survey of Health 2019. The assessed outcome was absenteeism from work. The burden of disease was assessed by simply counting a list of 14 morbidities and multimorbidity was defined as: \u2265two chronic diseases. Poisson regression models stratified by sex were used to estimate crude and adjusted prevalence ratios and their respective 95% confidence intervals.Of the 96,131,029 employed individuals, 38.5% reported absenteeism (95%CI 32.9-44.3). The most prevalent morbidities among women who reported absenteeism were back problems (50.8%), depression (42.9%), and hypertension (41.6%); and among men, hypertension (39.7%), chronic back pain (34.1%), and dyslipidemia (19.9%), among those who reported absenteeism. Having multimorbidity increased the report of absenteeism among women by 73% (95%CI 1.01-2.96); among men, there was no association after progressive adjustment for sociodemographic and health factors [PR 1.27 (95%CI 0.96-1.71)].The burden of disease and multimorbidity are highly prevalent among employed individuals and are strongly related to absenteeism from work, especially among women. In this sense, workers must be the target of interventions to reduce the impact of chronic noncommunicable diseases.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Absenteeism",
+ "Male",
+ "Female",
+ "Brazil",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Middle Aged",
+ "Chronic Disease",
+ "Noncommunicable Diseases",
+ "Prevalence",
+ "Health Surveys",
+ "Young Adult",
+ "Adolescent",
+ "Sex Distribution",
+ "Socioeconomic Factors",
+ "Cost of Illness",
+ "Multimorbidity",
+ "Sociodemographic Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "39697299",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Non-communicable diseases related multimorbidity, catastrophic health expenditure, and associated factors in Ernakulam district.",
+ "Abstract": "Multimorbidity, the coexistence of two or more chronic conditions in an individual, has emerged as a significant public health challenge with profound economic implications, exerting substantial strain on healthcare systems and economies worldwide. This study aimed to estimate the prevalence of non-communicable diseases (NCD) related multimorbidity, catastrophic health expenditure (CHE), and associated factors among adults aged \u226540\u202fyears in Ernakulam district.A community-based cross-sectional study was conducted among 420 individuals aged \u226540 years using population probability sampling. The tools used were the Multimorbidity Assessment Questionnaire for Primary Care (MAQ-PC), the WHO STEPS Questionnaire, and the Patient Health Questionnaire-9 (PHQ-9), which assessed non-communicable diseases, diet, physical activity, smoking, alcohol consumption, and depression. A pretested semi-structured questionnaire collected data on health and household expenditures. Multimorbidity was defined as having two or more self-reported NCDs, and CHE was identified when health costs exceeded 10% of a household's expenditure in the past month. Multivariable logistic regression was performed to find independent predictors of multimorbidity and CHE.The mean age of participants was 60.02\u202f\u00b1\u202f10\u202fyears. The prevalence of NCD multimorbidity was 42.6% (95% CI: 37.9-47.3%). The most common dyad was diabetes and hypertension (24.5, 95% CI: 20.4-28.6%). Higher odds of multimorbidity were observed in those aged \u226560 years (aOR\u202f=\u202f3.03, 95% CI: 1.95-4.73), unmarried/widowed/divorced (aOR\u202f=\u202f2.15, 95% CI: 1.28-3.63), unemployed (aOR\u202f=\u202f1.81, 95% CI: 1.14-2.87), and tobacco users (aOR\u202f=\u202f3.72, 95% CI: 1.85-7.48). Approximately 32.4% (95% CI: 25.5-39.3%) of households incurred catastrophic health expenditure (CHE) by treating adults with multimorbidity. Age\u202f\u2265\u202f60 (aOR\u202f=\u202f2.39, 95% CI: 1.99-5.77) and use of outpatient services (aOR\u202f=\u202f4.09, 95% CI: 2.01-8.32) were independently associated with higher odds of CHE. IP services and each additional morbidity add \u20b922,082.37 (\u202f=\u202f0.557, \u202f<\u202f0.001, 95% CI: \u20b917,139.88- \u20b927,024.86) and \u20b91,278.75 (\u202f=\u202f0.128, \u202f=\u202f0.044, 95%CI: \u20b935.58-\u20b92,521.92) to healthcare costs, respectively.The high prevalence of multimorbidity and associated CHE among individuals over 60\u202fyears highlights the urgent need for the National Programme for the Prevention and Control of Non-Communicable Diseases to prioritise multimorbidity and its management, especially above 60 years within this age group.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Multimorbidity",
+ "Noncommunicable Diseases",
+ "Health Expenditures",
+ "Prevalence",
+ "Aged",
+ "Adult",
+ "Surveys and Questionnaires"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "39696316",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Enhancing multi-sectoral collaborations for the prevention and control of NCDs in Thailand with a new approach.",
+ "Abstract": "To achieve the Sustainable Development Goals (SDGs) by 2030, Thailand must engage in effective multi-sectoral collaboration (MSC). However, implementing MSC in Thailand presents significant challenges. Although Thailand had a 2011-2020 MSC strategic plan for the control of non-communicable diseases (NCDs) with the prime minister taking the lead, joined by many non-health ministers, not a single meeting was called over those 10\u00a0years. This paper describes the development of a new tool created to enhance MSC between health and non-health sectors in controlling NCDs in Thailand. Stakeholder-engaged research will be used to implement and evaluate this tool. This paper also describes the research planned to test the new approach.The authors used two main methods: (1) a narrative review on MSC enhancement and (2) a series of four consultation meetings with key stakeholders - in the health, non-health and academic sectors - to develop a research study to implement and evaluate the new approach.To address previous MSC implementation problems, the proposed novel MSC enhancement approach emphasizes three principles: (1) pursuit of committed-stakeholder involvement at the middle-management level, instead of relying on the top-management level, an approach which has never been successful; (2) production of knowledge to support specific, achievable target policies; and (3) use of a comprehensive set of knowledge-translation activities and knowledge brokers to solve the problem of ineffective routine official communications between members of the MSC. Using participatory consultations during the research proposal development, middle-level officials from three non-health ministries (the Ministries of Agriculture, Finance and Education) agreed to join the MSC to work together to solve specific problems regarding the control of NCDs. A target-advocated policy for each ministry was formulated and agreed upon by both non-health-sector and health-sector stakeholders.This new approach (middle-management oriented), if implemented, may encourage more commitment from the Ministries' representatives, policy-relevant knowledge generation and effective communications between ministries involved in an MSC. Ideally, it would complement the conventional approach (top-management oriented) in enhancing the MSC for controlling NCDs, and thereby bring hope for achieving the NCD-related SDGs for Thailand and possibly other countries as well.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Thailand",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Stakeholder Participation",
+ "Health Policy",
+ "Sustainable Development",
+ "Intersectoral Collaboration",
+ "Cooperative Behavior"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "39696309",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Prevalence of diabetes and its associated factors in Cape Verde: an analysis of the 2020 WHO STEPS survey on non-communicable diseases risk factors.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) represents a significant global health challenge, with its prevalence steadily rising across diverse populations. Understanding the factors associated with T2DM is crucial for effective prevention and management strategies. In Cape Verde, an archipelago nation off the coast of West Africa, the burden of T2DM is of particular concern, yet comprehensive studies investigating its determinants in this context remain sparse. This study aims to narrow the knowledge gap by assessing the prevalence of prediabetes, T2DM and its associated factors among the adult Cape Verdean population.Data from the WHO STEPs survey were used. We analyzed data from 1,936 adults aged 18-69 years. The outcome variable was diabetes status computed using the fasting blood glucose (mg/dl). The data was weighted before the analysis to account for sampling biases. Multinomial logistic regression models were computed in STATA version 18.The overall prevalence of prediabetes and T2DM was 7.8% (95% CI: 6.1-9.9) and 3.9% (95% CI: 3.1-4.9), respectively. Increasing age was associated with a higher odd of prediabetes and T2DM with the highest odds observed among older adults [(prediabetes: AORs\u2009=\u20093.20, 95%CI: 1.88-5.54) and T2DM: AOR\u2009=\u20093.51, 95%CI: 1.71-7.18)]. Additionally, high total cholesterol levels were linked to increased odds of T2DM (AOR\u2009=\u20092.48, 95%CI: 1.64-3.76). Individuals who consumed less than four servings of vegetables daily had higher odds of T2DM (AOR\u2009=\u20091.74, 95%CI: 1.12-2.71) while being overweight/obese was associated with higher odds of prediabetes (AOR\u2009=\u20091.57, 95%CI: 1.10-2.23). Urban residents had higher odds of T2DM than rural residents (AOR\u2009=\u20091.92, 95%CI: 1.23-3.00). Also, higher educational attainment was associated with lower odds of T2DM only (AOR\u2009=\u20090.33, 95%CI: 0.12-0.88) but not statistically significant for prediabetes.Based on the findings, we conclude that ageing, overweight/obesity, vegetable consumption and total cholesterol level are important predictors of pre-diabetes and T2DM in Cape Verde. As such, weight management and cholesterol management should be integral parts of T2DM prevention strategies. Additionally, clinicians and diabetes societies in Cape Verde must make the promotion of vegetable consumption a key component of their health advice and advocacy.Not applicable.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Adult",
+ "Male",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Prevalence",
+ "Aged",
+ "Risk Factors",
+ "Adolescent",
+ "Young Adult",
+ "Cabo Verde",
+ "Prediabetic State",
+ "Noncommunicable Diseases",
+ "World Health Organization",
+ "Cross-Sectional Studies",
+ "Surveys and Questionnaires"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "39695503",
+ "Title": "BMC public health",
+ "ArticleTitle": "The relationship between non-communicable disease risk and mental wellbeing in adolescence: a cross-sectional study utilising objective measures in Indonesia.",
+ "Abstract": "Risk factors for non-communicable diseases (NCDs, cardiovascular diseases, cancers, chronic respiratory diseases, diabetes, and mental disorders) arise in adolescence but are mostly framed as relevant to health in adulthood; little is known about the relationship between co-occurring NCD risks and mental wellbeing in young people. This study aims to describe the prevalence and co-occurrence of distinct NCD risk factors, and how they relate to current mental wellbeing amongst adolescents in Indonesia, a young and populous country where NCD burden is increasing rapidly.We assessed NCD risk and mental wellbeing amongst 1,331 school-based 16-18-year-olds in Jakarta (N\u2009=\u2009609) and South Sulawesi (N\u2009=\u2009722). Five domains of NCD risk (adiposity, substance use, physical inactivity, excess sedentary time, and diet) were either measured or self-reported. In Jakarta, we also measured blood glucose, triglycerides, cholesterol, and blood pressure. Wellbeing was assessed using three indicators: general quality of life (QoL), physical function QoL, and psychological distress. We used linear regression to estimate the associations between co-occurring risks and wellbeing, adjusted for covariates of wellbeing: province, sex, socioeconomic status, and religion.NCD risk clustering was common, and more than half of adolescents had co-occurring risks in 3 or more of the 5 domains (58.9% (95%CI 53.7-63.9)). Adolescents with any NCD risk were more likely to report psychological distress, with this relationship most pronounced in those with excess sedentary time spent on video gaming and computer use. A higher number of NCD risk factors was associated with poorer psychological wellbeing and decreased general and physical function QoL. In the Jakarta subsample, reduced HDL and raised blood glucose was associated with psychological distress; and a higher number of risk biomarkers was associated with lower physical function QoL.Our analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Indonesia",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Cross-Sectional Studies",
+ "Risk Factors",
+ "Mental Health",
+ "Quality of Life",
+ "Prevalence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "39693027",
+ "Title": "Sub-cellular biochemistry",
+ "ArticleTitle": "Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.",
+ "Abstract": "A circadian disruption, manifested by disturbed sleep and low-grade inflammation, is commonly seen in noncommunicable diseases (NCDs). Cardiovascular, respiratory and renal disorders, diabetes and the metabolic syndrome, cancer, and neurodegenerative diseases are among the most common NCDs prevalent in today's 24-h/7\u00a0days Society. The decline in plasma melatonin, which is a conserved phylogenetic molecule across all known aerobic creatures, is a constant feature in NCDs. The daily evening melatonin surge synchronizes both the central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) and myriads of cellular clocks in the periphery (\"chronobiotic effect\"). Melatonin is the prototypical endogenous chronobiotic agent. Several meta-analyses and consensus studies support the use of melatonin to treat sleep/wake cycle disturbances associated with NCDs. Melatonin also has cytoprotective properties, acting primarily not only as an antioxidant by buffering free radicals, but also by regulating inflammation, down-regulating pro-inflammatory cytokines, suppressing low-grade inflammation, and preventing insulin resistance, among other effects. Melatonin's phylogenetic conservation is explained by its versatility of effects. In animal models of NCDs, melatonin treatment prevents a wide range of low-inflammation-linked alterations. As a result, the therapeutic efficacy of melatonin as a chronobiotic/cytoprotective drug has been proposed. Sirtuins 1 and 3 are at the heart of melatonin's chronobiotic and cytoprotective function, acting as accessory components or downstream elements of circadian oscillators and exhibiting properties such as mitochondrial protection. Allometric calculations based on animal research show that melatonin's cytoprotective benefits may require high doses in humans (in the 100\u00a0mg/day range). If melatonin is expected to improve health in NCDs, the low doses currently used in clinical trials (i.e., 2-10\u00a0mg) are unlikely to be beneficial. Multicentre double-blind studies are required to determine the potential utility of melatonin in health promotion. Moreover, melatonin dosage and levels used should be re-evaluated based on preclinical research information.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Melatonin",
+ "Humans",
+ "Animals",
+ "Antioxidants",
+ "Noncommunicable Diseases",
+ "Circadian Rhythm",
+ "Cytoprotection",
+ "Inflammation"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "39683555",
+ "Title": "Nutrients",
+ "ArticleTitle": "Risky Behaviors for Non-Communicable Diseases: Italian Adolescents' Food Habits and Physical Activity.",
+ "Abstract": "Driving adolescents to more correct food habits and physical activity is crucial to promoting health and avoiding the increase in morbidity and mortality in adulthood. Literature has focused on these behaviors in the adult population, while studies on adolescents are more limited. This study aims to explore the level of knowledge, attitudes, and behaviors regarding nutrition and physical activity to acquire insight into adolescents and identify the associated predictors.A cross-sectional study was conducted among adolescents aged 10 to 19 years from public middle and high schools randomly selected in the Campania Region, Southern Italy. A self-administered questionnaire, including closed and open-ended questions, assessed socio-demographic and health-related characteristics, dietary habits, physical activity, and sources of health information.Regarding socio-demographic and health-related characteristics, among 1433 adolescents who completed the survey, the mean age was 15.2 years, 50.5% were boys, 16.8% reported having a non-communicable disease, and 18% were overweight or obese. Multivariate analysis showed that older age, male gender, daily breakfast with at least one parent, higher self-rated knowledge on nutrition, awareness of fruit and vegetables consumption recommendations, correct dietary attitudes (daily breakfast, consumption of fruit and vegetables at least once a day, of legumes at least twice a week, and of carbonated sugary drinks less than once a day), the need for additional dietary information, meeting WHO physical activity recommendations, and less than two hours of daily screen time are determinants of a high quality diet score. Conversely, living with a single family member and current smoking were negatively associated with high quality diet. Older age, male gender, risk of alcohol abuse, higher quality diet, and lower mobile phone use are associated with meeting WHO physical activity recommendations. Since we investigated risky behaviors, potential limitations of this study could include social desirability and recall bias.Many adolescents lead unhealthy lifestyles, but younger adolescents and girls appear to be at higher risk of unhealthy behaviors. Targeted initiatives promoting regular physical activity and balanced diets in schools, involving parents and teachers in a collaborative plan, are essential to improving adolescents' health and well-being.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Italy",
+ "Exercise",
+ "Feeding Behavior",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Health Knowledge, Attitudes, Practice",
+ "Young Adult",
+ "Child",
+ "Adolescent Behavior",
+ "Surveys and Questionnaires",
+ "Health Risk Behaviors",
+ "Risk-Taking",
+ "Diet"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "17"
+ }
+ },
+ {
+ "PMID": "39678524",
+ "Title": "Iranian journal of medical sciences",
+ "ArticleTitle": "Clustering the Economic Status via Partitioning around Medoid and Its Association with Common Non-communicable Diseases.",
+ "Abstract": "During the last decades, the role of economic status and wealth-related variables in relation to the mortality and incidence of a wide range of diseases have received increased attention. This study focused on clustering the economic status of a population-based study using partitioning around the medoid (PAM) and then investigating the association between the obtained economic clusters and the incidence of non-communicable diseases (NCDs).The present study was based on data from Shahrekord Cohort Study (SCS). This study considered nine NCDs, including cardiac disease, myocardial infarction, diabetes, hypertension, stroke, all types of malignancies, chronic lung disease, depression, and obesity, among 7034 participants aged 35 and 70 from the urban population of Sharekord (IRAN) in 2022. Four quantitative and four qualitative variables were used to cluster the economic status. The package was used to determine the optimal number of clusters, and the K-med package in R software (version 4.2.1) was used for PAM clustering. Descriptive statistics were reported as frequency (%) or median (IQR), and statistical analysis was performed using the Chi square test and Mann-Whitney test in SPSS software (version 19.0). P<0.05 was considered statistically significant.The estimated optimal number of clusters was two. The first cluster contained individuals with good economic status, while the second cluster contained those with a moderate economic status. The findings indicated that individuals with a good economic status had significantly higher rates of cardiac disease (7.2% versus 5.3%, P<0.001), stroke (1.3% versus 0.6%, P<0.001), diabetes (12.8% versus 9.1%, P<0.001), hypertension (21.6% versus 15.6%, P<0.001), depression (P<0.001), and obesity (P=0.03).The findings of the present study showed that economic status was significantly associated with the majority of NCDs.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Iran",
+ "Economic Status",
+ "Cluster Analysis",
+ "Cohort Studies"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "16"
+ }
+ },
+ {
+ "PMID": "39671524",
+ "Title": "American journal of physical medicine & rehabilitation",
+ "ArticleTitle": "Correlation Between Self-reported or Supervised Physical Activity in Noncommunicable Diseases and Comorbidities During COVID-19 Pandemic: A Systematic Review.",
+ "Abstract": "The aim of the study is to systematically identify the protective and ameliorative effects of physical activity among people with noncommunicable diseases such as diabetes, cancer, chronic respiratory disease, chronic vascular disease, hypertension, and existing comorbidities during the coronavirus disease (COVID-19) pandemic.The trial is registered in the PROSPERO registry and used the PICO (population, intervention, comparison, and outcomes) strategy to perform the search strategy. Assessors analyzed related studies in the MEDLINE, PROQUEST, PubMed, Cochrane Library, CINAHL, Embase, Google Scholar, Physiotherapy Evidence, and Science Direct databases between December 2022 and January 2023. Researchers independently conducted a quality assessment of each study using a predeveloped quality assessment tool adapted from established tools for quantitative studies.Eighteen trials were included (chronic vascular disease-7, diabetes-4, hypertension-1, cancer-3, and chronic respiratory disease-3). The total number of individuals included in the systematic review was 780,003, and the total with or without COVID-19 was 188,435. Qualitative rating by the Newcastle-Ottawa Score for cross-sectional and cohort studies and the Physiotherapy Evidence Database scale revealed fair to good evidence for physical activity as a tool to reduce complications.There is evidence that exercise can protect people with noncommunicable diseases during the COVID-19 pandemic.Registration: Registered with Prospero registry.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Exercise",
+ "Comorbidity",
+ "Noncommunicable Diseases",
+ "SARS-CoV-2",
+ "Self Report",
+ "Pandemics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "13"
+ }
+ },
+ {
+ "PMID": "39662975",
+ "Title": "Global health, science and practice",
+ "ArticleTitle": "Service Delivery Redesign for Noncommunicable Disease Management: Assessment of Needs and Solutions Through a Co-Creation Process in Argentina.",
+ "Abstract": "In Argentina, the implementation of a national strategy to reduce the prevalence of noncommunicable diseases (NCDs) has been hampered by challenges at the provincial level. We aimed to design a new model of care for NCDs at the primary care level by conducting a multimodal system assessment and co-design of potential solutions in the province of Mendoza.We carried out a mixed-methods study with 7 components: evaluation of patterns of care, patient focus groups, cross-sectional standardized population-based phone survey, an electronic cohort follow-up of patients with type 2 diabetes, in-depth interviews with stakeholders, a knowledge test for health care providers on chronic condition management, and a Delphi consensus to provide recommendations from stakeholders.Focus group and in-depth interviews revealed access to primary health care for NCDs was associated with problems with long waiting times and time-consuming procedures for referral to laboratory tests, hospital care, and provision of medication. Mental health care services were particularly limited. Survey respondents (N=1,190) were predominantly covered through public (41%) or social security sectors (54%); 41% fell in the lowest income group. Contact with the health system was high (5.7 annual visits), but 19.7% reported unmet health care needs. Public sector providers perceived they provided high-quality care despite insufficient material and human resources. Within the social security sector, the main challenge was insufficient staff, particularly affecting mental health care. Health care providers showed a higher percentage of correct answers to depression-related questions, but worse results were seen in hypertension and diabetes care. Actions supported by evidence and expert agreement were identified for implementation to guide future system changes.Our research highlights the potential for Argentina's primary care system to initiate transformative, system-level changes aimed at improving health outcomes. We propose an innovative methodological assessment and co-design for improving primary care.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Argentina",
+ "Noncommunicable Diseases",
+ "Primary Health Care",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Delivery of Health Care",
+ "Focus Groups",
+ "Adult",
+ "Aged",
+ "Disease Management",
+ "Health Services Accessibility",
+ "Needs Assessment",
+ "Diabetes Mellitus, Type 2",
+ "Delphi Technique"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
+ },
+ {
+ "PMID": "39662129",
+ "Title": "Public health",
+ "ArticleTitle": "Non-communicable disease mortality and economic costs attributable to high body mass index in Argentina.",
+ "Abstract": "Non-communicable diseases (NCDs) such as cardiovascular diseases, respiratory diseases, and cancer represent a significant public health challenge in Argentina. This study aimed to estimate the burden of NCD mortality attributable to a high body mass index (BMI) in Argentina in 2018 and assess the associated economic costs.Comparative risk assessment modeling study.Potential impact fractions and preventable deaths were calculated under three counterfactual scenarios. Theoretical Minimum Risk Exposure Level (TMREL; mean BMI of 22.0\u00a0kg/m), 1.0\u00a0kg/m reduction in BMI, and returned to 2005 BMI levels. The years of life lost (YLLs) and economic costs in terms of productivity loss were also estimated.In 2018, nearly two-thirds of Argentina's adult population were overweight or obese. In the TMREL scenario, 24\u00a0% of major NCD deaths and 20\u00a0% of all-cause deaths could have been prevented if the population had a mean BMI of 22\u00a0kg/m. If a 1.0\u00a0kg/m reduction in BMI was achieved, 1.92\u00a0% of major NCD deaths and 3.48\u00a0% of all-cause deaths could have been avoided. Reducing the average BMI to the 2005 levels (25.8\u00a0kg/m) could have prevented 6\u00a0% of major NCD deaths and 8.8\u00a0% of all-cause deaths. The economic costs associated with high BMI-related mortality were estimated to be 0.37\u00a0% and 0.62\u00a0% of Argentina's GDP for major NCDs and all-cause mortality, respectively.The burden of NCD mortality and associated economic costs attributable to high BMI in Argentina are substantial, highlighting the urgent need for multi-sectoral interventions to address the increasing prevalence of overweight and obesity.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Argentina",
+ "Body Mass Index",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Adult",
+ "Middle Aged",
+ "Obesity",
+ "Aged",
+ "Cost of Illness",
+ "Risk Assessment",
+ "Overweight"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "12"
+ }
+ },
+ {
+ "PMID": "39658798",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Outcomes of an integrated knowledge translation approach in five African countries: a mixed-methods comparative case study.",
+ "Abstract": "Integrated knowledge translation (IKT) aims to enhance evidence-informed decision-making in public health and healthcare by establishing continuous relationships between researchers and knowledge users, in particular decision-makers. The Collaboration for Evidence-Based Healthcare and Public Health in Africa (CEBHA+) undertook research on noncommunicable diseases in Ethiopia, Malawi, Rwanda, South Africa and Uganda. Alongside the research activities, we implemented an IKT approach, which entailed training and the development and implementation of site-specific IKT strategies. We evaluated these strategies according to a predefined programme theory.Drawing on our published protocol ( https://rdcu.be/dyfBP ), we interviewed and surveyed CEBHA+\u2009researchers and their decision-making counterparts during two project stages (3/2020-2/2021; 9/2022-5/2023) and collected IKT-related documents. Transcripts and documents were analysed using qualitative content analysis and surveys were analysed descriptively, with subsequent integration, cross-case analysis and revision of the programme theory.A total of 36 researchers and 19 decision-makers participated in surveys, focus groups and/or interviews, and we collected 92 documents. Relationship building, capacity building and collaborative research were the most proximal intervention outcomes: CEBHA+\u2009researchers and their counterparts built mutual appreciation and partnerships, accessed contacts and networks, and expanded skills in conducting and using research and in IKT. The level of trust between partners varied. Intermediate outcomes were changes in attitudes and knowledge; beyond the conceptualization in our initial programme theory, researchers substantially increased their understanding of the decision-making context and developed a vision for \"research impact\". While it was challenging to evaluate distal outcomes, the IKT approach was linked to the production of research perceived as addressing local priorities and being highly applicable and contextualized, and some consideration of evidence among decision-makers. Unintended effects included high opportunity costs associated with undertaking IKT. An unanticipated outcome was the heightened interest of the research funder in policy engagement. Our updated programme theory constitutes a low-level theory for IKT.Whilst this study faced many challenges common to the evaluation of knowledge translation interventions, it presents rich, theory-informed insights into IKT outcomes. These are based on documented IKT activities and participants' views, particularly in-depth insights of researchers' experiences with implementing the CEBHA+\u2009IKT approach.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Translational Research, Biomedical",
+ "Humans",
+ "Ethiopia",
+ "Capacity Building",
+ "Decision Making",
+ "Research Personnel",
+ "Public Health",
+ "Malawi",
+ "Uganda",
+ "Noncommunicable Diseases",
+ "Cooperative Behavior",
+ "South Africa",
+ "Delivery of Health Care",
+ "Africa",
+ "Rwanda",
+ "Administrative Personnel",
+ "Focus Groups",
+ "Surveys and Questionnaires",
+ "Evidence-Based Practice",
+ "Qualitative Research",
+ "Health Policy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "39657648",
+ "Title": "Journal of physical activity & health",
+ "ArticleTitle": "Temporal Decomposition Analysis of Noncommunicable Disease Burden: The Interplay of Population Aging, Population Growth, and Low Physical Activity, 2010-2019.",
+ "Abstract": "To analyze global trends in the noncommunicable diseases (NCDs) burden attributable to low physical activity, considering the impacts of population aging and growth.Based on the Global Burden Disease 2019 Study, the NCDs-related death and disability-adjusted life years attributable to low physical activity (defined as <3000 metabolic equivalent-min/wk) were obtained from 2010 to 2019. The average annual percent change was calculated using the joinpoint analysis. Decomposition analysis was applied to assess the separated contributions of 3 components (population aging, population growth, and death change due to all other factors) on the overall change in NCDs death attributed to low physical activity.From 2010 to 2019, the average annual percent change of age-standardized rates of NCDs due to low physical activity was -0.09% for death and -0.06% for disability-adjusted life years. However, the global absolute number of deaths from NCDs attributable to low physical activity increased from 672,215 to 831,502, and disability-adjusted life years rose from 12,813,793 to 15,747,938. This rise was largely driven by population aging and growth, contributing to a 13.0% and 14.7% increase, respectively. The most significant impact of population aging on NCD deaths was observed in high-middle socio-demographic index countries (17.6%), whereas population growth had the greatest effect in low socio-demographic index countries (24.3%).The reduction in NCDs death rates attributed to low physical activity is insufficient to counteract the effects of population aging and growth. Targeted interventions for physical activity promotion should focus on the older population with special attention to diseases most sensitive to physical inactivity.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Exercise",
+ "Male",
+ "Population Growth",
+ "Female",
+ "Global Health",
+ "Aging",
+ "Global Burden of Disease",
+ "Aged",
+ "Disability-Adjusted Life Years",
+ "Middle Aged",
+ "Adult"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "39655600",
+ "Title": "Journal of hypertension",
+ "ArticleTitle": "Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients.",
+ "Abstract": "Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce.Baseline data (2021-2024) were collected in 168 sub-Saharan Blacks and 93 European Whites in an ongoing clinical trial (NCT04299529), using standardized patient selection criteria. Data included clinical and biochemical risk factors, ECG and echocardiographic traits, Framingham CVD risk, CKD grades (KDIGO 2024), self-assessed symptoms (WHO questionnaire), and urinary proteomic profiles predictive of left ventricular dysfunction (LVD) and CKD, HF1, and CKD273, respectively. Racial comparisons rested on unadjusted and multivariable-adjusted analyses.Despite being younger (60.4 vs. 68.3\u200ayears), blacks had a worse risk profile, as evidenced by higher diabetes prevalence, higher BMI, faster heart rate, unfavourable serum cholesterol fractions, lower estimated glomerular filtration rate, microalbuminuria, and sedentary lifestyle. This resulted in blacks having higher 10-year CVD risk, higher heart age (index of vascular ageing with chronological age as reference), and a worse CKD grades. In both races, CKD273 increased with CKD grade, but CKD273 and HF1 were not different by race. These observations were robust in subgroup and adjusted analyses.This study did not differentiate host (genetic, molecular, and pathogenic) from environmental drivers of disease. Nonetheless, the findings call for a multipronged and comprehensive implementation of innovative health policies in sub-Saharan countries. Education, research, empowerment of stakeholders, and international learned societies connecting experts from a wide array of disciplines should vigorously sustain this effort.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "White People",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Aged",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Black People",
+ "Africa South of the Sahara",
+ "Europe",
+ "Renal Insufficiency, Chronic",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
+ },
+ {
+ "PMID": "39653570",
+ "Title": "BMJ open",
+ "ArticleTitle": "Exploring symptoms perception and barriers to medication adherence among Thai Muslim patients with non-communicable diseases in a rural community in southern Thailand: a mixed-methods study.",
+ "Abstract": "This study aimed to explore the prevalence of medication non-adherence and influence of symptom perception and various barriers on medication adherence among Thai Muslim patients in a rural subdistrict of southern Thailand.Explanatory sequential mixed-methods approach.A rural community in southern Thailand.Data collection spanned from March to December 2023. In the quantitative phase, 138 Muslim patients diagnosed with non-communicable diseases were enrolled, and their medication adherence and associated factors were assessed. In the qualitative phase, 22 participants were selected for in-depth interviews, and their symptom perceptions and the obstacles they faced in adhering to medication were explored. A focus group discussion involving 10 healthcare workers from a subdistrict health-promoting hospital was conducted to gain insights into healthcare providers' perspectives on patients' perceptions of symptoms and barriers to medication adherence.Medication non-adherence was assessed, and the influence of symptom perception and various barriers on medication adherence was evaluated RESULTS: The prevalence of medication non-adherence in the study sample was 75.36%. The following factors were significantly associated with medication non-adherence: occupation (farmer) (adjusted OR=3.93; 95% CI 1.04 to 12.64), lack of recommendations on adjusting medication schedules/dosages during Ramadan (adjusted OR=2.65; 95% CI 1.06 to 6.61) and patients' perception of no symptoms (adjusted OR=3.72; 95%\u2009CI 1.23 to 11.25). The qualitative analysis highlighted patient-related issues, such as lack of symptom perception, limited health literacy regarding disease information and treatment and personal reasons for non-adherence (eg, forgetfulness, occupational constraints and transportation challenges for medical appointments). Additionally, healthcare system-related factors, patient-doctor relationships and communication gaps in medication management during Ramadan were identified as factors influencing medication non-adherence.To improve adherence, healthcare providers should prioritise fostering positive patient-provider relationships and promoting patient care through enhanced health literacy initiatives.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Medication Adherence",
+ "Thailand",
+ "Islam",
+ "Middle Aged",
+ "Noncommunicable Diseases",
+ "Rural Population",
+ "Adult",
+ "Focus Groups",
+ "Qualitative Research",
+ "Aged",
+ "Health Knowledge, Attitudes, Practice",
+ "Southeast Asian People",
+ "Assessment of Medication Adherence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
+ },
+ {
+ "PMID": "39653567",
+ "Title": "BMJ open",
+ "ArticleTitle": "Engaging stakeholders in Non-communicable diseases (NCDs) Implementation Research in low- and middle-income countries (LMICs): a scoping review protocol.",
+ "Abstract": "Non-communicable diseases (NCDs) present a significant health challenge globally, especially in low- and middle-income countries (LMICs). Effective Implementation Research (IR) is vital in addressing this challenge, with stakeholder engagement playing a crucial role. However, the landscape of stakeholder engagement in NCD IR within LMICs faces unique challenges, including resource constraints and power imbalances. Despite these challenges, stakeholder engagement offers substantial benefits, including improved research relevance and sustainability of interventions.This scoping review aims to comprehensively describe the current practices of stakeholder engagement in NCD IR within LMICs. Employing a two-stage screening process and a thematic synthesis approach based on the International Association for Public Participation Spectrum of Public Participation, the review will analyse studies meeting predefined eligibility criteria. A rigorous search strategy will be implemented across identified electronic databases and grey literature sources, including published studies from 2011 to present. Data will be charted using a standardised form, and information regarding study characteristics, NCD focus, LMIC context, stakeholder engagement method and reported outcomes/findings will be collected. This scoping review will follow a standard protocol adhering to the methodological framework outlined by Arksey and O'Malley to comprehensively map existing evidence on stakeholder engagement in NCD IR within LMICs.Ethical considerations involve respecting original authors, maintaining integrity and transparency, managing data ethically and disclosing conflicts of interest. Dissemination will occur through publication in peer-reviewed journals, conference presentations, open-access repositories, policy briefs, stakeholder engagement activities and social media platforms.This scoping review protocol is registered on Open Science Framework, with the Digital Object Identifier 10.17605/OSF.IO/ACQ52, ensuring transparency and accountability in the research process.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Developing Countries",
+ "Noncommunicable Diseases",
+ "Research Design",
+ "Stakeholder Participation",
+ "Implementation Science",
+ "Scoping Reviews As Topic"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "10"
+ }
+ },
+ {
+ "PMID": "39644320",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "The problems of functioning of health care system of the Kirghiz Republic and ways of their solving.",
+ "Abstract": "The article presents general analysis of national health care system of the Kirghiz Republic, including particular problems government agencies encounter, role of non-communicable diseases in increasing of total mortality, morbidity and disability of the population. The data is presented concerning economic losses associated with decreasing of labor productivity because of non-communicable diseases morbidity. The priority measures to strengthen primary health care organizations and ways of resolving existing problems in national health care are discussed.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Delivery of Health Care",
+ "Russia",
+ "Primary Health Care",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "8"
+ }
+ },
+ {
+ "PMID": "39644303",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "[The inadequate physical activity as risk factor of non-communicable diseases].",
+ "Abstract": "The article presents brief review of impact of inadequate physical activity on development of non-communicable diseases. The low physical activity is among top five most significant factors of premature death and is the cause of more than 20% of cases of diabetes mellitus II and chronic cardiovascular diseases. The article considers mode of assessing intensity of physical activity based on using metabolic equivalent. The effect of hypodynamia on development of obesity, diseases of musculoskeletal system, diabetes mellitus II, cardio-vascular and oncological diseases is considered. The relationship between inadequate physical activity and population mental health is considered too.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Exercise",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus, Type 2",
+ "Obesity"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "12",
+ "Day": "8"
+ }
+ },
+ {
+ "PMID": "39408232",
+ "Title": "Nutrients",
+ "ArticleTitle": "Bioactive Natural and Synthetic Products in Human Health and Diseases: Basic, Preclinical and Clinical Studies.",
+ "Abstract": "Since the early 20th century, the increase in non-communicable diseases such as diabetes, heart disease, stroke, and cancer compared to infectious diseases has led to chronic illnesses becoming a leading cause of global morbidity and mortality [...].",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biological Products",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "16"
+ }
+ },
+ {
+ "PMID": "39374955",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Non-communicable diseases: research priorities to mitigate impact of health system shocks.",
+ "Abstract": "argue that the long term impact of non-communicable diseases should be prioritised in planning the response to and management of future health shocks",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Research",
+ "Health Priorities",
+ "Biomedical Research"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "8"
+ }
+ },
+ {
+ "PMID": "39365121",
+ "Title": "Indian journal of dental research : official publication of Indian Society for Dental Research",
+ "ArticleTitle": "Dental Research and Noncommunicable Diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Dental Research"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
+ },
+ {
+ "PMID": "39363978",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Editorial: A gendered approach for accelerating prevention and control of NCDs.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Sex Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "10",
+ "Day": "4"
+ }
+ },
+ {
+ "PMID": "39307578",
+ "Title": "The Medical journal of Australia",
+ "ArticleTitle": "Pregnancy, childbirth and the postpartum period: opportunities to improve lifetime outcomes for women with non-communicable diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pregnancy",
+ "Female",
+ "Noncommunicable Diseases",
+ "Postpartum Period",
+ "Parturition",
+ "Pregnancy Complications",
+ "Australia"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "23"
+ }
+ },
+ {
+ "PMID": "39250188",
+ "Title": "Journal of medical Internet research",
+ "ArticleTitle": "Quality and Accountability of ChatGPT in Health Care in Low- and Middle-Income Countries: Simulated Patient Study.",
+ "Abstract": "Using simulated patients to mimic 9 established noncommunicable and infectious diseases, we assessed ChatGPT's performance in treatment recommendations for common diseases in low- and middle-income countries. ChatGPT had a high level of accuracy in both correct diagnoses (20/27, 74%) and medication prescriptions (22/27, 82%) but a concerning level of unnecessary or harmful medications (23/27, 85%) even with correct diagnoses. ChatGPT performed better in managing noncommunicable diseases than infectious ones. These results highlight the need for cautious AI integration in health care systems to ensure quality and safety.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Developing Countries",
+ "Patient Simulation",
+ "Quality of Health Care",
+ "Delivery of Health Care",
+ "Noncommunicable Diseases",
+ "Communicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "9",
+ "Day": "9"
+ }
+ },
+ {
+ "PMID": "39159632",
+ "Title": "The Lancet. Oncology",
+ "ArticleTitle": "Progress in NCD screening in Mongolia.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mass Screening",
+ "Mongolia",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "20"
+ }
+ },
+ {
+ "PMID": "39127467",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "Small island developing states: standing together on NCDs and mental health.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Developing Countries",
+ "Islands",
+ "Mental Disorders",
+ "Mental Health",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "39097835",
+ "Title": "The Medical journal of Australia",
+ "ArticleTitle": "Addressing the burdens of non-communicable and occupational diseases: now is always the time.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Occupational Diseases",
+ "Australia",
+ "Cost of Illness",
+ "Occupational Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "8",
+ "Day": "4"
+ }
+ },
+ {
+ "PMID": "39079134",
+ "Title": "Biomedica : revista del Instituto Nacional de Salud",
+ "ArticleTitle": "Following the roadmap outlined by the World health Organization: Innovation for the control of chronic noncommunicable diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "World Health Organization",
+ "Noncommunicable Diseases",
+ "Chronic Disease"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "38999912",
+ "Title": "Nutrients",
+ "ArticleTitle": "Insights into the Role of Vitamin D in the Prevention and Control of Cancer and Other Chronic Noncommunicable Diseases: Shedding Further Light on a Captivating Subject.",
+ "Abstract": "Vitamin D is a hormone that humans can synthesize upon sun exposure or through a balanced and healthy diet, including vitamin D-rich foods or supplements [...].",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Vitamin D",
+ "Noncommunicable Diseases",
+ "Neoplasms",
+ "Dietary Supplements",
+ "Vitamin D Deficiency",
+ "Chronic Disease",
+ "Sunlight"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "13"
+ }
+ },
+ {
+ "PMID": "38974250",
+ "Title": "African health sciences",
+ "ArticleTitle": "Editorial: Infections, non-communicable diseases, and reproductive health issues in a world beset by conflict and climate change.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Climate Change",
+ "Noncommunicable Diseases",
+ "Reproductive Health",
+ "Armed Conflicts",
+ "Communicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "8"
+ }
+ },
+ {
+ "PMID": "38969470",
+ "Title": "The Lancet. Planetary health",
+ "ArticleTitle": "The emerging syndemic of climate change and non-communicable diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Climate Change",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Syndemic",
+ "Global Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "6"
+ }
+ },
+ {
+ "PMID": "38962349",
+ "Title": "African health sciences",
+ "ArticleTitle": "Editor's choice: Tackling infectious diseases, NCDs and sexual reproductive health issues as we enter our 24 year of remarkable growth.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Reproductive Health",
+ "Sexual Health",
+ "Noncommunicable Diseases",
+ "Communicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "4"
+ }
+ },
+ {
+ "PMID": "38961778",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[i-Leviathan: towards precision public health?].",
+ "Abstract": "Hobbes' Leviathan symbolizes state sovereignty. In public health, this concept now extends to the prevention and promotion of health and the fight against non-communicable diseases (NCDs). This article explores the evolution towards an i-Leviathan, utilizing health data for more effective health surveillance. Precision public health, grounded in a personalized law approach, relies on the collection, availability, and use of these health data. This article analyzes the legal challenges of this precision, such as stigmatization, discrimination, and repression. It addresses the balance between public interests and individual freedoms, outlining state measures to monitor, control, and discipline healthy individuals.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Public Health",
+ "Precision Medicine",
+ "Noncommunicable Diseases",
+ "Health Promotion"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "7",
+ "Day": "4"
+ }
+ },
+ {
+ "PMID": "38909622",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "Non-communicable diseases in reproductive care.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Pregnancy"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "24"
+ }
+ },
+ {
+ "PMID": "38837205",
+ "Title": "Minerva pediatrics",
+ "ArticleTitle": "Perspectives on managing non-communicable diseases in pediatric health using artificial intelligence.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Artificial Intelligence",
+ "Noncommunicable Diseases",
+ "Child",
+ "Child Health",
+ "Pediatrics"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "6",
+ "Day": "5"
+ }
+ },
+ {
+ "PMID": "38760475",
+ "Title": "Nature reviews. Nephrology",
+ "ArticleTitle": "Kidney health within the broader non-communicable disease agenda.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Kidney Diseases",
+ "Renal Insufficiency, Chronic",
+ "Global Health"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "5",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "38633236",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Editorial: Impact of COVID-19 on the detection and control of chronic non-communicable diseases: repercussions on the sustainable development agenda.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sustainable Development",
+ "COVID-19",
+ "Noncommunicable Diseases",
+ "Conservation of Natural Resources",
+ "Developing Countries"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "38612813",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Special Issue \"Mitochondrial Dysfunction: A Common Trigger in Neurodegenerative and Metabolic Non-Communicable Diseases\".",
+ "Abstract": "Non-communicable diseases (NCDs) are non-infectious and non-transmissible chronic disorders [...].",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Mitochondrial Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "13"
+ }
+ },
+ {
+ "PMID": "38579988",
+ "Title": "Kidney international",
+ "ArticleTitle": "Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Renal Insufficiency, Chronic",
+ "Mortality, Premature",
+ "Noncommunicable Diseases",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "6"
+ }
+ },
+ {
+ "PMID": "38563505",
+ "Title": "The American journal of drug and alcohol abuse",
+ "ArticleTitle": "Targeting the Nlrp3 inflammasome as potential treatment for ethanol-induced non-communicable diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "NLR Family, Pyrin Domain-Containing 3 Protein",
+ "Humans",
+ "Inflammasomes",
+ "Noncommunicable Diseases",
+ "Ethanol",
+ "Animals"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "4",
+ "Day": "2"
+ }
+ },
+ {
+ "PMID": "38518297",
+ "Title": "Deutsches Arzteblatt international",
+ "ArticleTitle": "Altered Mortality From Selected Non-communicable Diseases During the COVID-19 Pandemic in Germany in 2020 and 2021.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Noncommunicable Diseases",
+ "Pandemics",
+ "Germany"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "23"
+ }
+ },
+ {
+ "PMID": "38485419",
+ "Title": "The Lancet. Global health",
+ "ArticleTitle": "Gout is a neglected non-communicable disease in the Pacific.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gout",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "15"
+ }
+ },
+ {
+ "PMID": "38461832",
+ "Title": "The Lancet. Oncology",
+ "ArticleTitle": "Non-communicable diseases in humanitarian settings.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Relief Work"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "38448166",
+ "Title": "Global health, science and practice",
+ "ArticleTitle": "The Thai Health Promotion Foundation: Two Decades of Joint Contributions to Addressing Noncommunicable Diseases and Creating Healthy Populations.",
+ "Abstract": "Globally, the current investment in preventive care is inadequate and ineffective for addressing noncommunicable diseases and their causes. The Thai Health Promotion Foundation, with its sustainable funding from 2% levies on tobacco and alcohol, together with partners, has been used to address noncommunicable diseases effectively.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Foundations",
+ "Health Promotion",
+ "Noncommunicable Diseases",
+ "Southeast Asian People",
+ "Thailand"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "3",
+ "Day": "7"
+ }
+ },
+ {
+ "PMID": "38415500",
+ "Title": "Chemical communications (Cambridge, England)",
+ "ArticleTitle": "NMR analysis of N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA.",
+ "Abstract": "The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using N-labeled NCD and H-N HSQC. In a fully saturated state, two NCD molecules consistently bind to each CGG/CGG unit, maintaining a 1\u2009:\u20092 binding stoichiometry.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Carbamates",
+ "Noncommunicable Diseases",
+ "Naphthyridines",
+ "DNA",
+ "Magnetic Resonance Spectroscopy",
+ "Trinucleotide Repeats"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "2",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "38397038",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Special Issue \"Peptides for Health Benefits 2021\".",
+ "Abstract": "In recent years, non-communicable diseases (NCDs) have increased in prevalence in our society and have become a serious burden of disease worldwide [...].",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Prevalence"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "2",
+ "Day": "24"
+ }
+ },
+ {
+ "PMID": "38356362",
+ "Title": "Disaster medicine and public health preparedness",
+ "ArticleTitle": "A National Laboratory Perspective: The Impact of the Covid-19 Pandemic on the Management of Patients With Non-Communicable Disease in South Africa: Impact of COVID-19 on patients with noncommunicable diseases - ERRATUM.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Noncommunicable Diseases",
+ "South Africa",
+ "Pandemics",
+ "SARS-CoV-2"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "2",
+ "Day": "15"
+ }
+ },
+ {
+ "PMID": "38349090",
+ "Title": "Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke",
+ "ArticleTitle": "[Premature mortality from noncommunicable diseases].",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mortality, Premature",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "2",
+ "Day": "13"
+ }
+ },
+ {
+ "PMID": "38242745",
+ "Title": "Social science & medicine (1982)",
+ "ArticleTitle": "Socio-economic gradients of health and health behaviors: From non-communicable diseases to breast feeding and back.",
+ "Abstract": "",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Female",
+ "Humans",
+ "Breast Feeding",
+ "Noncommunicable Diseases",
+ "Socioeconomic Factors",
+ "Health Behavior"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "1",
+ "Day": "20"
+ }
+ },
+ {
+ "PMID": "38240093",
+ "Title": "The Proceedings of the Nutrition Society",
+ "ArticleTitle": "Editorial.",
+ "Abstract": "Nutritional requirements of individuals vary across the lifecycle, according to activity, age and gender. To optimize human health, consideration of nutritional priorities at each stage is needed. This conference brought together multidisciplinary experts in maternal and child nutrition and health, cardiometabolic and plant-based nutrition and dietitians involved in the care of vulnerable populations, plus nutritional metabolism, health and ageing. The presentations highlighted the most important nutrition research in these areas, updating knowledge and suggesting how dietary advice and policy could be adapted to incorporate research findings. With the global increase in non-communicable disease (NCD) and nutrition being considered as a key modifiable risk factor for the prevention and management of NCD, this conference was much needed.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nutritional Requirements",
+ "Female",
+ "Child",
+ "Noncommunicable Diseases",
+ "Nutritional Status",
+ "Diet"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "1",
+ "Day": "19"
+ }
+ },
+ {
+ "PMID": "38236124",
+ "Title": "Georgian medical news",
+ "ArticleTitle": "ARTIFICIAL INTELLIGENCE: CREATING NEW PARADIGMS IN THE MANAGEMENT OF NON-COMMUNICABLE DISEASES.",
+ "Abstract": "The role of Artificial Intelligence (AI) in medical science is growing immensely. Since AI contains features that can address both preventive and therapeutic aspects of non-communicable diseases (NCDs), it can potentially lessen the massive burden of morbidity and mortality associated with NCDs. AI can help in various ways in NCDs including predicting disease occurrence, monitoring, ensuring treatment and follow-up of patients. Low- and middle-income countries can harness the benefit of AI for the management of chronic diseases and effectively address challenges like manpower shortage, accessibility to health care, etc. However, AI needs to be used responsibly and rationally in NCDs for its maximum benefit.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Artificial Intelligence",
+ "Noncommunicable Diseases",
+ "Health Facilities"
+ ],
+ "Date": {
+ "Year": "2024",
+ "Month": "1",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "38077262",
+ "Title": "Annals of global health",
+ "ArticleTitle": "Integrated Knowledge Translation for Non-Communicable Diseases: Stories from Sub-Saharan Africa.",
+ "Abstract": "Integrated Knowledge Translation (IKT) is a key strategy for contextualising, tailoring, and communicating research for policy and practice. In this viewpoint, we provide examples of how partners from five countries in sub-Saharan Africa used IKT to advance interventions for curbing non-communicable diseases in their contexts and how these strategies were magnified during the COVID-19 pandemic in some cases. The stories highlight the importance of deliberate and reinforced capacity building, authentic relationship enhancement, adaptable and user-informed stakeholder engagement, and agile multi-sectoral involvement.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Health Policy",
+ "Noncommunicable Diseases",
+ "Pandemics",
+ "Translational Science, Biomedical",
+ "Africa South of the Sahara"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "12",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "37898893",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "[The ways to resolve problems of forming reserve bed stock on purpose to decrease population mortality].",
+ "Abstract": "The article presents analysis of reduction of bed stock, including infectious hospitals, resulted from modernization, intensification and improvement efficiency of processes in health care of Russia. The pandemic of new coronavirus infectious COVID-19 led to increase of mortality not only because of this infection and its complications, but also to large extent from a number of other non-communicable diseases because of forced changes in system of medical care. The article analyzes mortality from the coronavirus infection COVID-19 and a number of non-communicable diseases. The ways of forming reserve bed stock to reduce population mortality are proposed.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "COVID-19",
+ "Delivery of Health Care",
+ "Hospitals",
+ "Russia"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "10",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "37743318",
+ "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
+ "ArticleTitle": "[Research progress on the comorbidity between hepatitis B virus infection and noncommunicable diseases].",
+ "Abstract": "With the decline in hepatitis B virus (HBV) incidence and the increase in the life expectancy of infected individuals, the population infected with HBV is experiencing rapid aging, leading to an escalating risk of co-morbid chronic noncommunicable diseases (NCDs). This study summarizes research related to the comorbidity between HBV and NCDs, discussing the aging of the HBV-infected population, the mechanisms, prevalence, and management of this comorbidity. This study provides insights into potential directions for future research on the comorbidity between HBV and NCDs and aims to provide a basis for further research and the development of prevention and treatment strategies for the comorbidity of NCDs among HBV-infected individuals in China.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hepatitis B virus",
+ "Noncommunicable Diseases",
+ "Hepatitis B",
+ "Comorbidity",
+ "China"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "9",
+ "Day": "25"
+ }
+ },
+ {
+ "PMID": "37506489",
+ "Title": "Seminars in immunology",
+ "ArticleTitle": "Inflammasomes as regulators of non-infectious disease.",
+ "Abstract": "Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components and highlight characteristics that permit inflammasome regulation of physiologic processes. We focus on emerging data that highlight the importance of inflammasome proteins in the regulation of reproduction, development, and malignancy. A framework is proposed to contextualize these findings.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Inflammasomes",
+ "Noncommunicable Diseases",
+ "Pyroptosis",
+ "Inflammation",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "7",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "37490794",
+ "Title": "Health & place",
+ "ArticleTitle": "Does urbanisation lead to unhealthy diets? Longitudinal evidence from Indonesia.",
+ "Abstract": "Urbanization is generally believed to contribute to dietary patterns that increase the risk of non-communicable disease (NCD). However, empirical evidence using nuanced measures of urbanization and longitudinal data is limited. This study examines the link between urbanization and dietary patterns in Indonesia, the largest country in Southeast Asia, between 2000 and 2015. Results show that urbanisation is associated with dietary patterns conducive to increased NCD risk-for example, high in soft drinks and ultra-processed foods-but also with higher consumption of healthier foods such as vegetables and fish. Results highlight important non-linearities and draw attention to the need to refrain from generalizations about the effect of urbanization on nutritional health.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Urbanization",
+ "Indonesia",
+ "Noncommunicable Diseases",
+ "Diet",
+ "Vegetables"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "7",
+ "Day": "25"
+ }
+ },
+ {
+ "PMID": "37483915",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Integrating maternal, newborn, child health and non-communicable disease care in the sustainable development goal era.",
+ "Abstract": "Noncommunicable diseases (NCDs) and maternal newborn and child health (MNCH) are two deeply intertwined health areas that have been artificially separated by global health policies, resource allocations and programming. Optimal MNCH care can provide a unique opportunity to screen for, prevent and manage early signs of NCDs developing in both the woman and the neonate. This paper considers how NCDs, NCD modifiable risk factors, and NCD metabolic risk factors impact MNCH. We argue that integrated management is essential, but this faces challenges that manifest across all levels of domestic health systems. Progress toward Sustainable Development targets requires joined-up action.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Child",
+ "Female",
+ "Infant, Newborn",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Sustainable Development",
+ "Child Health",
+ "Risk Factors",
+ "Global Health"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "7",
+ "Day": "24"
+ }
+ },
+ {
+ "PMID": "37265395",
+ "Title": "Community dental health",
+ "ArticleTitle": "Editorial: The WHO Global Oral Health Action Plan 2023-2030.",
+ "Abstract": "Oral health is finally on the global agenda. The World Health Organisation Global Oral Health Action Plan (OHAP) 2023-2030 (WHO, 2022a) has been completed following a public consultation which took place during August and September 2022. As oral diseases are the most prevalent non-communicable diseases; it is good to see that the OHAP will co-exist alongside the Global Action Plan for the Prevention and Control of Non-communicable Diseases 2013-2030. This editorial summarises the OHAP and highlights the opportunities and challenges discussed during the September 2022 EADPH congress, held co-jointly with the Council of the European Chief Dental Officers (CECDO).",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Oral Health",
+ "Noncommunicable Diseases",
+ "Global Health",
+ "World Health Organization",
+ "Mouth Diseases"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "6",
+ "Day": "2"
+ }
+ },
+ {
+ "PMID": "37218253",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "The 5A model for non- communicable disease advocacy.",
+ "Abstract": "We share a comprehensive 5A model which puts in perspective a clear-cut method to approach and address non communicable disease (NCD) advocacy. We suggest that the first step towards NCD control is awareness amongst health care professionals, and acceptance of their responsibility towards public health. Once this is done, active assertion follows, and leads to action on the ground. Regular audit, however, is necessary, to ensure effective and efficient advocacy for NCD. This model should be followed in all health care settings, including primary care diabetes.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Diabetes Mellitus",
+ "Communicable Disease Control",
+ "Health Personnel"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "5",
+ "Day": "23"
+ }
+ },
+ {
+ "PMID": "37034452",
+ "Title": "Annals of global health",
+ "ArticleTitle": "Increased Cardiovascular Mortality in Ecuador during COVID-19 Pandemic.",
+ "Abstract": "Before the COVID-19 pandemic, chronic noncommunicable diseases (NCDs), represented a high burden for low and middle-income countries. Patients with NCDs are at higher risk of COVID-19 and suffer worse clinical outcomes. We present mortality trends for myocardial infarction (AMI), stroke, hypertension (HT), and type-2 diabetes mellitus (T2DM) from 2005 to 2021 in Ecuador. The greatest increase in mortality observed in the pandemic was in AMI, T2DM, and HT. Factors related to COVID-19, health services, and patients with NCDs could contribute to these important increases in mortality.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Pandemics",
+ "Ecuador",
+ "Diabetes Mellitus, Type 2",
+ "Noncommunicable Diseases",
+ "Cardiovascular Diseases"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "4",
+ "Day": "11"
+ }
+ },
+ {
+ "PMID": "37021390",
+ "Title": "Chemical communications (Cambridge, England)",
+ "ArticleTitle": "Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules.",
+ "Abstract": "We report that a selective fluorescent indicator NBD-NCD for UGGAA repeats resulted in fluorescence quenching upon binding to RNA and recovered the fluorescence by displacing NBD-NCD with UGGAA repeat-targeted small molecules. The fluorescent indicator displacement assay using NBD-NCD can detect the interaction of small molecules with UGGAA repeats.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Fluorescent Dyes",
+ "RNA",
+ "Spectrometry, Fluorescence"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "4",
+ "Day": "7"
+ }
+ },
+ {
+ "PMID": "36848254",
+ "Title": "Journal of computational biology : a journal of computational molecular cell biology",
+ "ArticleTitle": "Evaluating Compression-Based Phylogeny Estimation in the Presence of Incomplete Lineage Sorting.",
+ "Abstract": "This study assesses characteristics of the normalized compression distance (NCD) technique for building phylogenetic trees from molecular data. We examined results from a mammalian biological data set as well as a collection of simulated data with varying levels of incomplete lineage sorting. The implementation of NCD we analyze is a concatenation-based, distance-based, alignment-free, and model-free phylogeny estimation method, which takes concatenated unaligned sequence data as input and outputs a matrix of distances. We compare the NCD phylogeny estimation method with various other methods, including coalescent- and concatenation-based methods.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Phylogeny",
+ "Noncommunicable Diseases",
+ "Computer Simulation",
+ "Data Compression",
+ "Mammals"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "2",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "36799325",
+ "Title": "Revue medicale de Liege",
+ "ArticleTitle": "[Syndemics and non infectious diseases].",
+ "Abstract": "The concept of \"syndemics\" is getting more and more popularity in scientific journals, especially since the end of the first decade of the current century. It relates to the dynamic interaction of synchronous or sequential diseases (whether communicable or not, also including mental diseases), with social and environmental factors, resulting at the end in a worse global outcome. A first article in the same Journal (1) was devoted to infectious diseases, especially COVID-19 and HIV infections. In this second article, we highlight the fact that the concept is also applicable on diseases which are not transmitted by infectious pathogens. The importance of considering action within the field of social determinants of care will be illustrated by a limited selection of examples.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "HIV Infections",
+ "Syndemic",
+ "Noncommunicable Diseases",
+ "COVID-19"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "2",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "36797570",
+ "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
+ "ArticleTitle": "[Significance of preventing developmental origins of diseases in improving population quality].",
+ "Abstract": "More studies show that various diseases, especially chronic non-infectious diseases, have developmental origin. Developmental origins of diseases are mainly due to gametes and early life development stage being exposed to adverse environment, resulting in abnormal modification of epigenetic and stable inheritance to the adult stage, which could make the risk of various long-term diseases of individuals high. The theory of developmental origin provides a new perspective for the occurrence and development of diseases, and also provides a theoretical basis for disease prevention. Attaching importance to maternal and child health care and life-cycle management is conducive to the prevention of developmental diseases and is of great significance to the improvement of population quality.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Humans",
+ "Epigenesis, Genetic",
+ "Chronic Disease",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "2",
+ "Day": "17"
+ }
+ },
+ {
+ "PMID": "36780208",
+ "Title": "Journal of medical Internet research",
+ "ArticleTitle": "The Metaverse, the Built Environment, and Public Health: Opportunities and Uncertainties.",
+ "Abstract": "There has been a growing interest in the \"metaverse,\" and discourse about how this platform may contribute to different fields of science is already beginning to emerge. In this paper, we discuss key opportunities and uncertainties about how a metaverse might contribute to advancing knowledge in the interdisciplinary field of the built environment and public health aimed at reducing noncommunicable diseases.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Public Health",
+ "Built Environment",
+ "Interdisciplinary Studies",
+ "Knowledge",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2023",
+ "Month": "2",
+ "Day": "14"
+ }
+ },
+ {
+ "PMID": "36286971",
+ "Title": "Terapevticheskii arkhiv",
+ "ArticleTitle": "[Non-infectious diseases of the aorta and large arteries].",
+ "Abstract": "This article describes the various forms of inflammatory lesions of the aorta and large arteries, including chronic periaortitis, as well as the diagnostic methods are considered. Large vessel vasculitis represent the most common entities, however, there is also an association with other rheumatological or inflammatory diseases, drug-induced or paraneoplastic entities. Instrumental imaging modalities play an important role in the diagnosis.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Takayasu Arteritis",
+ "Giant Cell Arteritis",
+ "Noncommunicable Diseases",
+ "Aorta",
+ "Arteries"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "10",
+ "Day": "27"
+ }
+ },
+ {
+ "PMID": "36065699",
+ "Title": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
+ "ArticleTitle": "[Correlation between Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Signaling Pathway and Non-infectious Diseases].",
+ "Abstract": "As a DNA receptor in the cytoplasm,cyclic GMP-AMP synthase (cGAS) can recognize abnormal DNA in the cytoplasm and activate stimulator of interferon genes (STING) to regulate the immune response. The recent studies have demonstrated that this pathway plays a role in non-infectious inflammatory diseases by promoting the expression of type \u2160 interferon and interferon-stimulated gene.This article reviews the activation and regulation of cGAS-STING pathway in multiple systems and the effect of this pathway on the occurrence and progression of non-infectious inflammatory diseases,providing theoretical reference for future application of cGAS-STING pathway-related drugs in non-infectious inflammatory diseases.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Interferons",
+ "Membrane Proteins",
+ "Noncommunicable Diseases",
+ "Nucleotides, Cyclic",
+ "Nucleotidyltransferases",
+ "Signal Transduction"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "9",
+ "Day": "7"
+ }
+ },
+ {
+ "PMID": "36007874",
+ "Title": "Journal of cancer policy",
+ "ArticleTitle": "Cancer research in Pakistan: Opportunities, challenges and the way forward.",
+ "Abstract": "Chronic disease disparities, in low and middle income countries (LMICs), need to be addressed through research to improve health equity. Most LMICs including Pakistan have a huge burden of non communicable disease (NCDs) like cancer and a high number of deaths due to cancer. National Cancer Control Programmes are recommended for countries with high cancer burden like Pakistan to ensure systematic implementation of evidence based strategies for cancer control however there is limited capacity for evidence generation through research. We describe the existing status for cancer registries and research in Pakistan and suggest a syndemic framework to prioritize contextually relevant research which can advance cancer health equity for Pakistani population.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Developing Countries",
+ "Pakistan",
+ "Noncommunicable Diseases",
+ "Health Equity",
+ "Chronic Disease",
+ "Neoplasms"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "8",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "35951624",
+ "Title": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
+ "ArticleTitle": "Inflammation and diet: Focus on mental and cognitive health.",
+ "Abstract": "It has been well established that chronic low-grade inflammation is implicated in both physical and mental noncommunicable diseases. Diet, a leading risk factor for non-communicable diseases, has been repeatedly shown to be related to inflammation, as well as various health outcomes, including mental and cognitive health. In the current editorial paper, we briefly summarize the current state of evidence and discuss the potential mediating role of inflammation between diet and mental/cognitive health. We also outline our perspective on challenges and future research directions in the domain of inflammation and diet, with a specific focus on mental and cognitive health.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Cognition",
+ "Diet",
+ "Humans",
+ "Inflammation",
+ "Mental Disorders",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "8",
+ "Day": "12"
+ }
+ },
+ {
+ "PMID": "35886388",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Non-Pharmacological Interventions for the Management of Chronic Health Conditions and Non-Communicable Diseases.",
+ "Abstract": "A chronic health condition has been defined by the World Health Organization (WHO) as a disease being of long duration, generally slow in progression and not passed from person to person; that is to say, a non-communicable disease (NCD) [...].",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Chronic Disease",
+ "Humans",
+ "Noncommunicable Diseases",
+ "World Health Organization"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "28"
+ }
+ },
+ {
+ "PMID": "35873168",
+ "Title": "Frontiers in cellular and infection microbiology",
+ "ArticleTitle": "Pathogenic or Therapeutic: The Mediating Role of Gut Microbiota in Non-Communicable Diseases.",
+ "Abstract": "Noncommunicable diseases (NCDs) lead to 41 million deaths every year and account for 71% of all deaths worldwide. Increasing evidence indicates that gut microbiota disorders are closely linked to the occurrence and development of diseases. The gut microbiota, as a potential transmission medium, could play a key role in the transmission and treatment of diseases. The gut microbiota makes noncommunicable diseases communicable. New methods of the prevention and treatment of these diseases could be further explored through the gut microbiota.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Fecal Microbiota Transplantation",
+ "Gastrointestinal Microbiome",
+ "Humans",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "35833343",
+ "Title": "Tropical doctor",
+ "ArticleTitle": "Pyrexia of unknown origin and its aetiology in Pakistan.",
+ "Abstract": "Pyrexia of unknown origin (PUO) and its aetiology vary considerably according to geography. We conducted a retrospective study to update our knowledge of PUO in Pakistan. PUO was defined as a febrile illness of >3 weeks' duration, a temperature of >38.3\u00b0C, and >3 outpatient visits or 3 days' hospitalization. Infection was the cause in 47.1%, malignancy in 23.1%, noninfectious inflammatory disease in 21.8%, miscellaneous causes in 1.2%, and in 6.8%, the cause of the fever was not found.",
+ "Predictions": [
+ "Non-Communicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Fever of Unknown Origin",
+ "Hospitalization",
+ "Humans",
+ "Neoplasms",
+ "Noncommunicable Diseases",
+ "Pakistan",
+ "Retrospective Studies"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "15"
+ }
+ },
+ {
+ "PMID": "35791628",
+ "Title": "Tropical doctor",
+ "ArticleTitle": "Prevalence of communicable and non-communicable diseases among adult immigrants from Venezuela at a university hospital in Colombia from 2017 to 2018.",
+ "Abstract": "Since 2015 immigration has increased significantly into Colombia. As immigrants who are not insured to the national health system present to public hospitals for medical care. However, there is little knowledge about the prevalence of communicable and non-communicable diseases amongst them. Ours was a cross-sectional study at a university hospital reviewing 154 medical records of Venezuelan immigrants treated by the Internal Medicine Specialty between 2017 & 2018. Non-communicable diseases representing 66.3% are the main cause of hospitalization, possibly owing to poor primary care.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Colombia",
+ "Cross-Sectional Studies",
+ "Emigrants and Immigrants",
+ "Hospitals, University",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Prevalence",
+ "Venezuela"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "7"
+ }
+ },
+ {
+ "PMID": "35787510",
+ "Title": "BMJ global health",
+ "ArticleTitle": "Models of lifelong care for children and adolescents with chronic conditions in low-income and middle-income countries: a scoping review.",
+ "Abstract": "Globally, non-communicable diseases (NCDs) or chronic conditions account for one-third of disability-adjusted life-years among children and adolescents under the age of 20. Health systems must adapt to respond to the growing burden of NCDs among children and adolescents who are more likely to be marginalised from healthcare access and are at higher risk for poor outcomes. We undertook a review of recent literature on existing models of chronic lifelong care for children and adolescents in low-income and middle-income countries with a variety of NCDs and chronic conditions to summarise common care components, service delivery approaches, resources invested and health outcomes.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Child",
+ "Chronic Disease",
+ "Developing Countries",
+ "Humans",
+ "Income",
+ "Noncommunicable Diseases",
+ "Poverty"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "7",
+ "Day": "6"
+ }
+ },
+ {
+ "PMID": "35165420",
+ "Title": "Nature cell biology",
+ "ArticleTitle": "Telomere dysfunction in ageing and age-related diseases.",
+ "Abstract": "Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Age Factors",
+ "Aging",
+ "Animals",
+ "Cellular Senescence",
+ "DNA Damage",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Telomere",
+ "Telomere Homeostasis",
+ "Telomere Shortening"
+ ],
+ "Date": {
+ "Year": "2022",
+ "Month": "2",
+ "Day": "16"
+ }
+ },
+ {
+ "PMID": "33683330",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Hospital Admissions Associated With Noncommunicable Diseases During the COVID-19 Outbreak in Brazil.",
+ "Abstract": "This cross-sectional study uses data from the Brazilian Unified Health System to compare the number of hospital admissions for treatment of noncommunicable diseases from January to June 2020 with that during the corresponding period in each of the previous 3 years in S\u00e3o Paulo, Brazil.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Brazil",
+ "COVID-19",
+ "Cross-Sectional Studies",
+ "Hospitalization",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Pandemics",
+ "SARS-CoV-2"
+ ],
+ "Date": {
+ "Year": "2021",
+ "Month": "3",
+ "Day": "9"
+ }
+ },
+ {
+ "PMID": "32969614",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Non-communicable diseases and vulnerable populations: overview of the situation and vision for the future].",
+ "Abstract": "The care of vulnerable people with non-communicable diseases faces numerous barriers including difficulties in identifying affected people, lack of time, resources, tools and skills to address these issues, poor intersectoral work between health-care and social work. We plea for a systematic public policy which allows to implement intersectoral collaborations at all levels.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Delivery of Health Care",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Vulnerable Populations"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "9",
+ "Day": "25"
+ }
+ },
+ {
+ "PMID": "32859194",
+ "Title": "BMC international health and human rights",
+ "ArticleTitle": "A renewed call for transdisciplinary action on NCDs.",
+ "Abstract": "Notwithstanding COVID-19, non-communicable diseases (NCDs) will be the leading cause of death in every region in the world by 2030. This contribution, which forms an introduction to our collection of articles in this journal, identifies elements for a transdisciplinary research agenda between law, public health, health economics and international relations aimed at designing concrete interventions to curb the NCD pandemic, both globally and domestically.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Cause of Death",
+ "Global Health",
+ "Humans",
+ "Interdisciplinary Research",
+ "Noncommunicable Diseases",
+ "Pandemics"
+ ],
+ "Date": {
+ "Year": "2020",
+ "Month": "8",
+ "Day": "30"
+ }
+ },
+ {
+ "PMID": "31859214",
+ "Title": "Trends in endocrinology and metabolism: TEM",
+ "ArticleTitle": "Science and Health Policies to Tackle Chronic Diseases in Chile.",
+ "Abstract": "Chile has experienced rapid epidemiological transitions characterized by decreasing infant mortality, population aging, and a shift towards obesity with an increase in noncommunicable diseases (NCDs). Today, tobacco, alcohol, and ultraprocessed foods are the main risk factors for these diseases. Based on Chile's experience in tobacco control, we discuss paths to make progress in population evidence-based strategies to improve overall community health.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Alcoholic Beverages",
+ "Chile",
+ "Chronic Disease",
+ "Food",
+ "Health Policy",
+ "Humans",
+ "Legislation as Topic",
+ "Noncommunicable Diseases",
+ "Public Health",
+ "Science",
+ "Tobacco Products"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "12",
+ "Day": "21"
+ }
+ },
+ {
+ "PMID": "31323738",
+ "Title": "Nutrients",
+ "ArticleTitle": "Diet and Chronic Diseases: Is There a Mediating Effect of Inflammation?",
+ "Abstract": "Chronic non-communicable diseases like cardiovascular disease (CVD) and diabetes represent the majority of the current burden of disease worldwide, with higher rates and impacts in developed countries but also with alarming trends in developing countries [...].",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Diet",
+ "Humans",
+ "Inflammation",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "7",
+ "Day": "22"
+ }
+ },
+ {
+ "PMID": "31164325",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "International trade and investment: still the foundation for tackling nutrition related non-communicable diseases in the era of Trump?",
+ "Abstract": "Trade and investment policy strongly influence diet, nutrition, and risk of non-communicable disease\u2014but what does this mean in the context of recent global political developments?",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Commerce",
+ "Diet",
+ "Economics",
+ "Food Industry",
+ "Humans",
+ "Internationality",
+ "Investments",
+ "Noncommunicable Diseases",
+ "Nutritional Physiological Phenomena",
+ "Nutritional Status",
+ "Risk Factors"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "6",
+ "Day": "6"
+ }
+ },
+ {
+ "PMID": "31110030",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Asking the right question: implementation research to accelerate national non-communicable disease responses.",
+ "Abstract": "Non-communicable disease programmes can be strengthened by systematically identifying implementation challenges and translating them into questions that can be answered through appropriate research, say",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Cost of Illness",
+ "Global Health",
+ "Government Programs",
+ "Health Plan Implementation",
+ "Humans",
+ "Intersectoral Collaboration",
+ "Noncommunicable Diseases",
+ "Public Health",
+ "Research"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "5",
+ "Day": "22"
+ }
+ },
+ {
+ "PMID": "31060489",
+ "Title": "Current vascular pharmacology",
+ "ArticleTitle": "Advanced Glycation End Products in Chinese Medicine Mediated Aging Diseases: A Review.",
+ "Abstract": "Aging has become a worldwide problem. During this process, the incidence of related diseases such as diabetes and atherosclerosis increases dramatically. Studies within the most recent two decades suggest a pivotal role of Advanced Glycation End Products (AGEs) in the aging process. This review aims to systemically summarize the effects and potential mechanism of Chinese Medicines on inhibiting AGEs-related aging diseases.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Age Factors",
+ "Aging",
+ "Animals",
+ "Apoptosis",
+ "Drugs, Chinese Herbal",
+ "Energy Metabolism",
+ "Glycation End Products, Advanced",
+ "Humans",
+ "Inflammation Mediators",
+ "Medicine, Chinese Traditional",
+ "Noncommunicable Diseases",
+ "Oxidative Stress",
+ "Risk Factors",
+ "Signal Transduction"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "5",
+ "Day": "8"
+ }
+ },
+ {
+ "PMID": "30799814",
+ "Title": "Medecine et sante tropicales",
+ "ArticleTitle": "HIV-AIDS and noncommunicable diseases: a shared vision.",
+ "Abstract": "Although different in nature, HIV/AIDS and the noncommunicable diseases have many issues in common: the importance of rapid screening, the high cost of treatment, patients' treatment adherence, and the challenge of integrating services in basic health facilities, especially in the South. Several lessons can be drawn today from the fight against AIDS (about community involvement, the organization of research, free treatment, and the mobilization of funding) that can nourish strategic thinking for the fight against noncommunicable diseases.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Africa",
+ "Anti-Retroviral Agents",
+ "Community Health Services",
+ "HIV Infections",
+ "Health Services Accessibility",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Patient Compliance",
+ "Patient Education as Topic"
+ ],
+ "Date": {
+ "Year": "2019",
+ "Month": "2",
+ "Day": "26"
+ }
+ },
+ {
+ "PMID": "30293505",
+ "Title": "International journal of health services : planning, administration, evaluation",
+ "ArticleTitle": "Cuba's Strategy Toward Universal Health.",
+ "Abstract": "After 40 years of the Alma Ata Declaration on primary health care, the Pan American Journal of Public Health published an actualized overview of Cuban policies on health and well-being. It describes the longstanding and successful experience of this socialist country, developed in adverse and complex circumstances. The Cuban case remains one of the leading examples of a comprehensive governmental approach toward population health and well-being. The analysis underscores the essential role of continued political will toward population health.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Cuba",
+ "Delivery of Health Care",
+ "Humans",
+ "Internationality",
+ "Noncommunicable Diseases",
+ "Politics",
+ "Primary Health Care",
+ "Research",
+ "Universal Health Care"
+ ],
+ "Date": {
+ "Year": "2018",
+ "Month": "10",
+ "Day": "9"
+ }
+ },
+ {
+ "PMID": "30243951",
+ "Title": "Explore (New York, N.Y.)",
+ "ArticleTitle": "Shifting Food Systems: Increasing Well-Being Through Plant-Based Approaches.",
+ "Abstract": "Growing evidence reveals food production systems and consumption practices contradict goals for environmental well-being and population health. This interdisciplinary paper reviews research for impacts from diets on non-communicable human diseases, climate change, and animal well-being. With increasing pressures to innovate and reduce economic as well as emotional costs associated with ill-health, our recommendations could positively impact policy.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Climate Change",
+ "Conservation of Natural Resources",
+ "Diet",
+ "Food Supply",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Plants",
+ "Policy",
+ "Population Health"
+ ],
+ "Date": {
+ "Year": "2018",
+ "Month": "9",
+ "Day": "24"
+ }
+ },
+ {
+ "PMID": "29952785",
+ "Title": "AIDS (London, England)",
+ "ArticleTitle": "Building on the HIV platform: tackling the challenge of noncommunicable diseases among persons living with HIV.",
+ "Abstract": ": The global HIV response has enabled access to prevention and treatment interventions for millions of people around the world. This investment has enabled the strengthening of health systems, which offers a remarkable opportunity to integrate care for noncommunicable diseases for persons living with HIV who are at risk for or have a noncommunicable disease.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Disease Management",
+ "Global Health",
+ "HIV Infections",
+ "Health Services Administration",
+ "Humans",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2018",
+ "Month": "6",
+ "Day": "29"
+ }
+ },
+ {
+ "PMID": "29904042",
+ "Title": "Medical science monitor basic research",
+ "ArticleTitle": "The Challenge of Stress-Related Non-Communicable Diseases.",
+ "Abstract": "The greatest challenge facing medicine today involves the so-called non-communicable diseases (NCDs). This is true regardless of whether one's location is considered high-income, middle-income, or low-income. Basic research at all \"OMICs\" system levels will be significant in uncovering causal links that create NCD vulnerabilities in mind, brain, body, and society. Therefore, meeting this 21st century challenge by improving NCD management and prevention around the world will rely on advancement in this type of basic research.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases"
+ ],
+ "Date": {
+ "Year": "2018",
+ "Month": "6",
+ "Day": "16"
+ }
+ },
+ {
+ "PMID": "29147040",
+ "Title": "Bulletin of the World Health Organization",
+ "ArticleTitle": "Countries urged to take tough action to prevent NCDs.",
+ "Abstract": "Uruguay is hosting the WHO Global Conference on Noncommunicable Diseases (NCDs) this month, from 18-20 October. Tabar\u00e9 V\u00e1zquez, the President of Uruguay, tells the about his country's efforts to prevent and fight NCDs and why countries should step up the global response.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Chronic Disease",
+ "Health Promotion",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Primary Health Care",
+ "Uruguay",
+ "World Health Organization"
+ ],
+ "Date": {
+ "Year": "2017",
+ "Month": "11",
+ "Day": "18"
+ }
+ },
+ {
+ "PMID": "27818410",
+ "Title": "Journal of health care for the poor and underserved",
+ "ArticleTitle": "U.S. Associated Pacific Islands Health Care Teams Chart a Course for Improved Health Systems: Implementation and Evaluation of a Non-communicable Disease Collaborative Model.",
+ "Abstract": "The burden of non-communicable disease (NCD) is increasing in the U.S. Associated Pacific Islands (USAPI). We describe the implementation and evaluation of a NCD Collaborative pilot, using local trainers, as an evidence-based strategy to systematically strengthen NCD health care quality and outcomes, focusing on diabetes preventive care across five health systems in the region.",
+ "Predictions": [
+ "Non-Communicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Needs Assessment",
+ "Noncommunicable Diseases",
+ "Obesity",
+ "Pacific Islands",
+ "Patient Care Team"
+ ],
+ "Date": {
+ "Year": "2016",
+ "Month": "11",
+ "Day": "8"
+ }
+ }
+]
\ No newline at end of file
diff --git a/testModel/dataset/noncommunicable_diseases.json b/testModel/dataset/noncommunicable_diseases.json
deleted file mode 100644
index a339352e0..000000000
--- a/testModel/dataset/noncommunicable_diseases.json
+++ /dev/null
@@ -1,2254 +0,0 @@
-[
- {
- "PMID": "39737510",
- "Title": "The Indian journal of medical research",
- "ArticleTitle": "Prevalence of risk factors of non-communicable diseases among adults in urban slums of Burdwan municipality, West Bengal: A cross sectional study.",
- "Abstract": "Background & objectives Non communicable diseases (NCD) have emerged as one of the leading causes of mortality and morbidity in India in the past few decades. This study was undertaken to determine the prevalence of NCD risk factors among adults residing in urban slums of West Bengal, India. Methods A community based cross-sectional study was conducted among adult population aged 15-69 yr in urban slums of Purba Burdwan district, West Bengal over a period of two months. A total of with 180 study participants selected by simple random sampling. Data were collected using a semi-structured schedule, adopted from the WHO STEPS questionnaire. Analysis was done using Chi-square test and logistic analysis. P<0.05 was considered to be significant. Results The prevalence of alcohol intake, smoking, inadequate vegetable and fruit intake, reduced physical activity and overweight and/or obesity was 27.8, 15.6 , 93.3 , 32.8 and 15.5 per cent, respectively among the study population. A significant association of smoking was found among males [Adjusted odds ratio (AOR) 2.54 Confidence interval (CI):1.76-6.99], those living in joint families (AOR 1.24 CI:1.17-1.34) and without any formal education (AOR 3.22 CI:1.50-13.87). The odds of alcohol consumption alcohol, were higher among those aged >44 yr (AOR 1.98 CI:1.34-7.22), males (AOR 2.65 CI:1.89-8.76), those who had no formal education (AOR 1.43 CI:1.23-2.77) and those who were employed (AOR 1.34 CI:1.02-4.09). Again respondents aged 45-69 yr (AOR 4.45 CI:1.79-10.99) and married (AOR 3.77 CI:1.76-7.44) were associated with overweight and or/obesity. Furthermore, age AOR 5.04 CI:1.34-17.98) and employment status (AOR 1.78 CI:1.67-3.09) were significantly associated with raised blood pressure in multivariate analysis. Interpretation & conclusions The high prevalence of risk factors of NCD in the study population is suggestive of a need for health promotion by creating awareness about the dangers of smoking and alcohol consumption as well as educating the people about the benefits of physical activity and eating a healthy diet.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Adult",
- "Middle Aged",
- "India",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Aged",
- "Poverty Areas",
- "Adolescent",
- "Prevalence",
- "Smoking",
- "Alcohol Drinking",
- "Obesity",
- "Cross-Sectional Studies",
- "Young Adult",
- "Urban Population"
- ]
- },
- {
- "PMID": "39737504",
- "Title": "The Indian journal of medical research",
- "ArticleTitle": "Stem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.",
- "Abstract": "Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy. Results Of the 9206 studies screened, 61 studies that were relevant to stem cell use for non-malignant diseases were included for analysis. Autologous stem cells (75%) were used predominantly compared to allogenic stem cells (18.33%), followed by mixed type (6.67%). Use of bone marrow-derived stem cells (51%) was dominant, followed by melanocytes (19%), adipose (7%), haematopoietic (12%), and (11%) other types of stem cells. The study revealed 37 randomized clinical trial studies conducted in the government research hospital compared to the non-government. Interpretation & conclusions Maintaining the gold standard for stem cell therapy requires randomized clinical trials with large sample sizes, control groups, failures, adverse effects, etc. It is important to have a monitoring and regulation system in stem cell clinical research activities with enough preclinical data and repeated exchanges between the bench and the bedside.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "India",
- "Stem Cell Transplantation",
- "Cell- and Tissue-Based Therapy",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39736607",
- "Title": "International journal for equity in health",
- "ArticleTitle": "Social and economic impacts of non-communicable diseases by gender and its correlates: a literature review.",
- "Abstract": "NCDs pose a significant social and economic burden due to their impact on the health of the population, healthcare systems, and the economies of households and nations, which will likely increase over time. This impact is closely related to gender, although it has been scarcely documented. Public policies aimed at enhancing access and achieving UHC are essential to guarantee effective financial protection in health, especially for the most vulnerable sectors of the population.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Sex Factors",
- "Employment",
- "Socioeconomic Factors",
- "Poverty",
- "Universal Health Insurance",
- "Cost of Illness"
- ]
- },
- {
- "PMID": "39732655",
- "Title": "BMC public health",
- "ArticleTitle": "Bias in machine learning applications to address non-communicable diseases at a population-level: a scoping review.",
- "Abstract": "This review examines current applications of ML in NCDs, highlighting potential biases and strategies for mitigation. Future research should focus on communicable diseases and the transferability of ML models in low and middle-income settings. Our findings can guide the development of guidelines for the equitable use of ML to improve population health outcomes.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Machine Learning",
- "Bias",
- "Population Health",
- "Algorithms"
- ]
- },
- {
- "PMID": "39731009",
- "Title": "BMC public health",
- "ArticleTitle": "Investigating the influence of working status changes on physical activity and non-communicable diseases in Korean middle-aged and older adults: insights from a longitudinal panel study.",
- "Abstract": "This longitudinal study revealed that individuals engaged in or transitioning to employment displayed a reduced likelihood of regular PA. Moreover, those with work history, transitioning, or consistently working, exhibited increased vulnerability to all NCDs compared to those without work experience.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Republic of Korea",
- "Male",
- "Female",
- "Middle Aged",
- "Longitudinal Studies",
- "Noncommunicable Diseases",
- "Exercise",
- "Employment",
- "Aged",
- "Risk Factors"
- ]
- },
- {
- "PMID": "39725416",
- "Title": "BMJ open",
- "ArticleTitle": "How does the level of functional impairment vary in individuals with non-communicable disease and comorbidity? Cross-sectional analysis of linked census and administrative data in Aotearoa New Zealand.",
- "Abstract": "Functional impairment was strongly patterned by NCD type. NCD prevention efforts and disability supports are needed to reduce the burden of disability experienced.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "New Zealand",
- "Cross-Sectional Studies",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Noncommunicable Diseases",
- "Adult",
- "Comorbidity",
- "Censuses",
- "Adolescent",
- "Young Adult",
- "Aged, 80 and over",
- "Prevalence",
- "Child",
- "Child, Preschool"
- ]
- },
- {
- "PMID": "39722627",
- "Title": "Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit",
- "ArticleTitle": "The impact of health taxes on consumption of tobacco and sugar-sweetened beverages in the Eastern Mediterranean Region.",
- "Abstract": "Consumption of tobacco, nicotine and sugar-sweetened beverages (SSBs) poses a significant risk to public health, contributing to increases in noncommunicable diseases (NCDs) such as cardiovascular disease, diabetes, cancer, and obesity. Globally, regular consumption of SSBs increases the risk of type 2 diabetes by 26%, and deaths related to tobacco and nicotine consumption exceed 8 million annually, including 1.3 million due to exposure to second-hand smoke. This loss of lives and the negative impact on health underscore the urgent need for effective public health interventions to curb the consumption of these harmful products.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Sugar-Sweetened Beverages",
- "Taxes",
- "Tobacco Products",
- "Mediterranean Region",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39709790",
- "Title": "Redox biology",
- "ArticleTitle": "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.",
- "Abstract": "Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE). The products of these genes participate in numerous functions including biotransformation and redox homeostasis, lipid and iron metabolism, inflammation, proteostasis, as well as mitochondrial dynamics and energetics. Thus, it is possible that a single pharmacological NRF2 modulator might mitigate the effect of the main hallmarks of NCDs, including oxidative, proteostatic, inflammatory and/or metabolic stress. Research on model organisms has provided tremendous knowledge of the molecular mechanisms by which NRF2 affects NCDs pathogenesis. This review is a comprehensive summary of the most commonly used model organisms of NCDs in which NRF2 has been genetically or pharmacologically modulated, paving the way for drug development to combat NCDs. We discuss the validity and use of these models and identify future challenges.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "NF-E2-Related Factor 2",
- "Humans",
- "Animals",
- "Noncommunicable Diseases",
- "Oxidative Stress",
- "Reactive Oxygen Species",
- "Oxidation-Reduction",
- "Disease Models, Animal",
- "Inflammation",
- "Gene Expression Regulation"
- ]
- },
- {
- "PMID": "39702198",
- "Title": "BMC geriatrics",
- "ArticleTitle": "Age- and sex-disaggregated disease burden among the older persons in India.",
- "Abstract": "This comprehensive assessment of the differentials in disease burden among older persons across age, sex and states of India, and the gaps identified in the service utilisation data capture by age and sex for the older persons in the national health programs can provide crucial inputs for strengthening the on-going public health policy and programmatic efforts aimed at improving the health and well-being of the growing older population in India.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Aged",
- "Female",
- "Male",
- "India",
- "Middle Aged",
- "Aged, 80 and over",
- "Noncommunicable Diseases",
- "Cost of Illness",
- "Disability-Adjusted Life Years",
- "Sex Factors",
- "Age Factors",
- "Global Burden of Disease",
- "Wounds and Injuries"
- ]
- },
- {
- "PMID": "39699459",
- "Title": "Revista brasileira de epidemiologia = Brazilian journal of epidemiology",
- "ArticleTitle": "Chronic noncommunicable diseases and absenteeism from work: National Survey of Health, 2019.",
- "Abstract": "The burden of disease and multimorbidity are highly prevalent among employed individuals and are strongly related to absenteeism from work, especially among women. In this sense, workers must be the target of interventions to reduce the impact of chronic noncommunicable diseases.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Absenteeism",
- "Male",
- "Female",
- "Brazil",
- "Cross-Sectional Studies",
- "Adult",
- "Middle Aged",
- "Chronic Disease",
- "Noncommunicable Diseases",
- "Prevalence",
- "Health Surveys",
- "Young Adult",
- "Adolescent",
- "Sex Distribution",
- "Socioeconomic Factors",
- "Cost of Illness",
- "Multimorbidity",
- "Sociodemographic Factors"
- ]
- },
- {
- "PMID": "39697299",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Non-communicable diseases related multimorbidity, catastrophic health expenditure, and associated factors in Ernakulam district.",
- "Abstract": "The high prevalence of multimorbidity and associated CHE among individuals over 60\u202fyears highlights the urgent need for the National Programme for the Prevention and Control of Non-Communicable Diseases to prioritise multimorbidity and its management, especially above 60 years within this age group.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Middle Aged",
- "Male",
- "Female",
- "Cross-Sectional Studies",
- "Multimorbidity",
- "Noncommunicable Diseases",
- "Health Expenditures",
- "Prevalence",
- "Aged",
- "Adult",
- "Surveys and Questionnaires"
- ]
- },
- {
- "PMID": "39696316",
- "Title": "Health research policy and systems",
- "ArticleTitle": "Enhancing multi-sectoral collaborations for the prevention and control of NCDs in Thailand with a new approach.",
- "Abstract": "This new approach (middle-management oriented), if implemented, may encourage more commitment from the Ministries' representatives, policy-relevant knowledge generation and effective communications between ministries involved in an MSC. Ideally, it would complement the conventional approach (top-management oriented) in enhancing the MSC for controlling NCDs, and thereby bring hope for achieving the NCD-related SDGs for Thailand and possibly other countries as well.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Thailand",
- "Humans",
- "Noncommunicable Diseases",
- "Stakeholder Participation",
- "Health Policy",
- "Sustainable Development",
- "Intersectoral Collaboration",
- "Cooperative Behavior"
- ]
- },
- {
- "PMID": "39696309",
- "Title": "BMC endocrine disorders",
- "ArticleTitle": "Prevalence of diabetes and its associated factors in Cape Verde: an analysis of the 2020 WHO STEPS survey on non-communicable diseases risk factors.",
- "Abstract": "Not applicable.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Middle Aged",
- "Adult",
- "Male",
- "Female",
- "Diabetes Mellitus, Type 2",
- "Prevalence",
- "Aged",
- "Risk Factors",
- "Adolescent",
- "Young Adult",
- "Cabo Verde",
- "Prediabetic State",
- "Noncommunicable Diseases",
- "World Health Organization",
- "Cross-Sectional Studies",
- "Surveys and Questionnaires"
- ]
- },
- {
- "PMID": "39695503",
- "Title": "BMC public health",
- "ArticleTitle": "The relationship between non-communicable disease risk and mental wellbeing in adolescence: a cross-sectional study utilising objective measures in Indonesia.",
- "Abstract": "Our analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Mental Health"
- ],
- "MeshTerms": [
- "Humans",
- "Indonesia",
- "Adolescent",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Cross-Sectional Studies",
- "Risk Factors",
- "Mental Health",
- "Quality of Life",
- "Prevalence"
- ]
- },
- {
- "PMID": "39693027",
- "Title": "Sub-cellular biochemistry",
- "ArticleTitle": "Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.",
- "Abstract": "A circadian disruption, manifested by disturbed sleep and low-grade inflammation, is commonly seen in noncommunicable diseases (NCDs). Cardiovascular, respiratory and renal disorders, diabetes and the metabolic syndrome, cancer, and neurodegenerative diseases are among the most common NCDs prevalent in today's 24-h/7\u00a0days Society. The decline in plasma melatonin, which is a conserved phylogenetic molecule across all known aerobic creatures, is a constant feature in NCDs. The daily evening melatonin surge synchronizes both the central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) and myriads of cellular clocks in the periphery (\"chronobiotic effect\"). Melatonin is the prototypical endogenous chronobiotic agent. Several meta-analyses and consensus studies support the use of melatonin to treat sleep/wake cycle disturbances associated with NCDs. Melatonin also has cytoprotective properties, acting primarily not only as an antioxidant by buffering free radicals, but also by regulating inflammation, down-regulating pro-inflammatory cytokines, suppressing low-grade inflammation, and preventing insulin resistance, among other effects. Melatonin's phylogenetic conservation is explained by its versatility of effects. In animal models of NCDs, melatonin treatment prevents a wide range of low-inflammation-linked alterations. As a result, the therapeutic efficacy of melatonin as a chronobiotic/cytoprotective drug has been proposed. Sirtuins 1 and 3 are at the heart of melatonin's chronobiotic and cytoprotective function, acting as accessory components or downstream elements of circadian oscillators and exhibiting properties such as mitochondrial protection. Allometric calculations based on animal research show that melatonin's cytoprotective benefits may require high doses in humans (in the 100\u00a0mg/day range). If melatonin is expected to improve health in NCDs, the low doses currently used in clinical trials (i.e., 2-10\u00a0mg) are unlikely to be beneficial. Multicentre double-blind studies are required to determine the potential utility of melatonin in health promotion. Moreover, melatonin dosage and levels used should be re-evaluated based on preclinical research information.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Melatonin",
- "Humans",
- "Animals",
- "Antioxidants",
- "Noncommunicable Diseases",
- "Circadian Rhythm",
- "Cytoprotection",
- "Inflammation"
- ]
- },
- {
- "PMID": "39683555",
- "Title": "Nutrients",
- "ArticleTitle": "Risky Behaviors for Non-Communicable Diseases: Italian Adolescents' Food Habits and Physical Activity.",
- "Abstract": "Many adolescents lead unhealthy lifestyles, but younger adolescents and girls appear to be at higher risk of unhealthy behaviors. Targeted initiatives promoting regular physical activity and balanced diets in schools, involving parents and teachers in a collaborative plan, are essential to improving adolescents' health and well-being.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Adolescent",
- "Male",
- "Female",
- "Italy",
- "Exercise",
- "Feeding Behavior",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Health Knowledge, Attitudes, Practice",
- "Young Adult",
- "Child",
- "Adolescent Behavior",
- "Surveys and Questionnaires",
- "Health Risk Behaviors",
- "Risk-Taking",
- "Diet"
- ]
- },
- {
- "PMID": "39678524",
- "Title": "Iranian journal of medical sciences",
- "ArticleTitle": "Clustering the Economic Status via Partitioning around Medoid and Its Association with Common Non-communicable Diseases.",
- "Abstract": "The findings of the present study showed that economic status was significantly associated with the majority of NCDs.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Middle Aged",
- "Adult",
- "Aged",
- "Iran",
- "Economic Status",
- "Cluster Analysis",
- "Cohort Studies"
- ]
- },
- {
- "PMID": "39671524",
- "Title": "American journal of physical medicine & rehabilitation",
- "ArticleTitle": "Correlation Between Self-reported or Supervised Physical Activity in Noncommunicable Diseases and Comorbidities During COVID-19 Pandemic: A Systematic Review.",
- "Abstract": "There is evidence that exercise can protect people with noncommunicable diseases during the COVID-19 pandemic.Registration: Registered with Prospero registry.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "COVID-19",
- "Exercise",
- "Comorbidity",
- "Noncommunicable Diseases",
- "SARS-CoV-2",
- "Self Report",
- "Pandemics"
- ]
- },
- {
- "PMID": "39662975",
- "Title": "Global health, science and practice",
- "ArticleTitle": "Service Delivery Redesign for Noncommunicable Disease Management: Assessment of Needs and Solutions Through a Co-Creation Process in Argentina.",
- "Abstract": "Our research highlights the potential for Argentina's primary care system to initiate transformative, system-level changes aimed at improving health outcomes. We propose an innovative methodological assessment and co-design for improving primary care.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Argentina",
- "Noncommunicable Diseases",
- "Primary Health Care",
- "Male",
- "Female",
- "Cross-Sectional Studies",
- "Middle Aged",
- "Delivery of Health Care",
- "Focus Groups",
- "Adult",
- "Aged",
- "Disease Management",
- "Health Services Accessibility",
- "Needs Assessment",
- "Diabetes Mellitus, Type 2",
- "Delphi Technique"
- ]
- },
- {
- "PMID": "39662129",
- "Title": "Public health",
- "ArticleTitle": "Non-communicable disease mortality and economic costs attributable to high body mass index in Argentina.",
- "Abstract": "The burden of NCD mortality and associated economic costs attributable to high BMI in Argentina are substantial, highlighting the urgent need for multi-sectoral interventions to address the increasing prevalence of overweight and obesity.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Argentina",
- "Body Mass Index",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Adult",
- "Middle Aged",
- "Obesity",
- "Aged",
- "Cost of Illness",
- "Risk Assessment",
- "Overweight"
- ]
- },
- {
- "PMID": "39658798",
- "Title": "Health research policy and systems",
- "ArticleTitle": "Outcomes of an integrated knowledge translation approach in five African countries: a mixed-methods comparative case study.",
- "Abstract": "Whilst this study faced many challenges common to the evaluation of knowledge translation interventions, it presents rich, theory-informed insights into IKT outcomes. These are based on documented IKT activities and participants' views, particularly in-depth insights of researchers' experiences with implementing the CEBHA+\u2009IKT approach.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Translational Research, Biomedical",
- "Humans",
- "Ethiopia",
- "Capacity Building",
- "Decision Making",
- "Research Personnel",
- "Public Health",
- "Malawi",
- "Uganda",
- "Noncommunicable Diseases",
- "Cooperative Behavior",
- "South Africa",
- "Delivery of Health Care",
- "Africa",
- "Rwanda",
- "Administrative Personnel",
- "Focus Groups",
- "Surveys and Questionnaires",
- "Evidence-Based Practice",
- "Qualitative Research",
- "Health Policy"
- ]
- },
- {
- "PMID": "39655600",
- "Title": "Journal of hypertension",
- "ArticleTitle": "Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients.",
- "Abstract": "This study did not differentiate host (genetic, molecular, and pathogenic) from environmental drivers of disease. Nonetheless, the findings call for a multipronged and comprehensive implementation of innovative health policies in sub-Saharan countries. Education, research, empowerment of stakeholders, and international learned societies connecting experts from a wide array of disciplines should vigorously sustain this effort.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "White People",
- "Female",
- "Male",
- "Middle Aged",
- "Aged",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Black People",
- "Africa South of the Sahara",
- "Europe",
- "Renal Insufficiency, Chronic",
- "Cardiovascular Diseases"
- ]
- },
- {
- "PMID": "39653570",
- "Title": "BMJ open",
- "ArticleTitle": "Exploring symptoms perception and barriers to medication adherence among Thai Muslim patients with non-communicable diseases in a rural community in southern Thailand: a mixed-methods study.",
- "Abstract": "To improve adherence, healthcare providers should prioritise fostering positive patient-provider relationships and promoting patient care through enhanced health literacy initiatives.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Female",
- "Medication Adherence",
- "Thailand",
- "Islam",
- "Middle Aged",
- "Noncommunicable Diseases",
- "Rural Population",
- "Adult",
- "Focus Groups",
- "Qualitative Research",
- "Aged",
- "Health Knowledge, Attitudes, Practice",
- "Southeast Asian People",
- "Assessment of Medication Adherence"
- ]
- },
- {
- "PMID": "39653567",
- "Title": "BMJ open",
- "ArticleTitle": "Engaging stakeholders in Non-communicable diseases (NCDs) Implementation Research in low- and middle-income countries (LMICs): a scoping review protocol.",
- "Abstract": "This scoping review protocol is registered on Open Science Framework, with the Digital Object Identifier 10.17605/OSF.IO/ACQ52, ensuring transparency and accountability in the research process.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Developing Countries",
- "Noncommunicable Diseases",
- "Research Design",
- "Stakeholder Participation",
- "Implementation Science",
- "Scoping Reviews As Topic"
- ]
- },
- {
- "PMID": "39645277",
- "Title": "Best practice & research. Clinical gastroenterology",
- "ArticleTitle": "The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders.",
- "Abstract": "Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health. Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led to a significant shift in dietary habits over the past century, with an increased diffusion of the Western diet (WD). WD includes foods high in saturated fat, refined sugars, salt, sweeteners, and low in fiber, and is characterized by overeating, frequent snacking, and a prolonged postprandial state. An increasing body of evidence supports the association between the diffusion of WD and the rising prevalence of NCDs. WD also negatively affects both gut microbiota and the immune system by driving to microbial alterations, gut barrier dysfunction, increased intestinal permeability, and leakage of harmful bacterial metabolites into the bloodstream, with consequent contribution to the development of systemic low-grade inflammation. In this review article we aim to dissect the role of gut microbiota imbalance and gut barrier impairment in mediating the detrimental effects of WD on the development of NCDs, and to identify potential therapeutic strategies.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Chronic Disease",
- "Diet, Western",
- "Gastrointestinal Microbiome",
- "Inflammation",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39644320",
- "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
- "ArticleTitle": "The problems of functioning of health care system of the Kirghiz Republic and ways of their solving.",
- "Abstract": "The article presents general analysis of national health care system of the Kirghiz Republic, including particular problems government agencies encounter, role of non-communicable diseases in increasing of total mortality, morbidity and disability of the population. The data is presented concerning economic losses associated with decreasing of labor productivity because of non-communicable diseases morbidity. The priority measures to strengthen primary health care organizations and ways of resolving existing problems in national health care are discussed.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Delivery of Health Care",
- "Russia",
- "Primary Health Care",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39644303",
- "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
- "ArticleTitle": "[The inadequate physical activity as risk factor of non-communicable diseases].",
- "Abstract": "The article presents brief review of impact of inadequate physical activity on development of non-communicable diseases. The low physical activity is among top five most significant factors of premature death and is the cause of more than 20% of cases of diabetes mellitus II and chronic cardiovascular diseases. The article considers mode of assessing intensity of physical activity based on using metabolic equivalent. The effect of hypodynamia on development of obesity, diseases of musculoskeletal system, diabetes mellitus II, cardio-vascular and oncological diseases is considered. The relationship between inadequate physical activity and population mental health is considered too.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cardiovascular diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Exercise",
- "Cardiovascular Diseases",
- "Diabetes Mellitus, Type 2",
- "Obesity"
- ]
- },
- {
- "PMID": "39632114",
- "Title": "BMJ open",
- "ArticleTitle": "Engaging Australian healthcare consumers to determine priorities and consensus for precision medicine approaches to detect non-communicable disease in early life: a modified Delphi study.",
- "Abstract": "Our findings indicate the majority (98%) of participants in our study believe early screening for risk of NCD in their children was acceptable, provided it was equitable and clear pathways for referral and support were available.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Delphi Technique",
- "Precision Medicine",
- "Noncommunicable Diseases",
- "Consensus",
- "Female",
- "Australia",
- "Pregnancy",
- "Adult",
- "Male",
- "Mass Screening",
- "Middle Aged",
- "Health Priorities"
- ]
- },
- {
- "PMID": "39625743",
- "Title": "JMIR research protocols",
- "ArticleTitle": "Development and Validation of a Novel Tool to Measure Medication Adherence for Noncommunicable Diseases in India: Protocol for an Exploratory Sequential Mixed Methods Multicentric Study.",
- "Abstract": "PRR1-10.2196/60805.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "India",
- "Noncommunicable Diseases",
- "Male",
- "Female",
- "Surveys and Questionnaires",
- "Reproducibility of Results",
- "Multicenter Studies as Topic",
- "Assessment of Medication Adherence"
- ]
- },
- {
- "PMID": "39622542",
- "Title": "BMJ global health",
- "ArticleTitle": "Food insecurity is associated with greater difficulty accessing care among people living with HIV with or without comorbid non-communicable diseases in western Kenya.",
- "Abstract": "We found that greater food insecurity was associated with greater difficulty accessing care among PLWH with or without NCDs in rural western Kenya. These findings suggest that addressing social determinants of health may be necessary when implementing integrated HIV and NCD care programmes.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Kenya",
- "Food Insecurity",
- "Male",
- "Female",
- "HIV Infections",
- "Adult",
- "Health Services Accessibility",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Comorbidity",
- "Young Adult",
- "Food Supply"
- ]
- },
- {
- "PMID": "39613439",
- "Title": "BMJ open",
- "ArticleTitle": "Prevalence of physical inactivity and associated factors among adults in Eastern African countries: a systematic review and meta-analysis protocol.",
- "Abstract": "CRD42024567592.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Systematic Reviews as Topic",
- "Sedentary Behavior",
- "Meta-Analysis as Topic",
- "Prevalence",
- "Risk Factors",
- "Exercise",
- "Adult",
- "Africa, Eastern",
- "Research Design",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39602608",
- "Title": "Gaceta medica de Mexico",
- "ArticleTitle": "Burden of disease in older adults in Mexico, 1990-2022: time trends and challenges for the health system.",
- "Abstract": "LE-60 increases were not accompanied by reductions in disability due to functional decline, highlighting the need for healthcare strategies to enhance healthy aging.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Mexico",
- "Cost of Illness",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Disability-Adjusted Life Years",
- "Healthy Aging",
- "Mortality",
- "Life Expectancy",
- "Prevalence",
- "Incidence",
- "Humans",
- "Male",
- "Female",
- "Middle Aged",
- "Aged",
- "Aged, 80 and over",
- "Delivery of Health Care",
- "Health Services Needs and Demand"
- ]
- },
- {
- "PMID": "39595773",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "Decentralization Matters: Association of Adherence to Treatment and Distance for the Management of Non-Communicable Diseases in Rural Tanzania.",
- "Abstract": "Since March 2019, a non-communicable diseases program has been established at hospital level, with enrollment and clinical reassessment every 6 months. Since July 2023, monthly enrollment and visits have also been conducted at health center level. This study aimed at assessing the adherence to scheduled follow-up visits following the decentralization of the integrated NCDs program from Hospital to Health Center level and investigate factors influencing follow-up adherence. The study was performed in a rural district in Iringa Region, Tanzania. Adherence was measured at both levels. Multivariate regression analysis was conducted to describe socio-demographic and clinical factors influencing attendance at the 6-month hospital-level visit. Among 2198 patients enrolled at the hospital level, weighted adherence over 42 months was 40.8% (95% CI 39.0-42.6%) at the 6-month visit. Multivariate analysis revealed that as the distance from the hospital increased, the probability of attendance decreased (OR 0.17; 95% CI: 0.08-0.39). Among 571 patients enrolled at the residence level, adherence over the first 10 months of program implementation was 91.6% (90.4-92.8%). The findings showed that distance was by far the most important barrier to follow-up adherence and suggested that decentralizing the program from the hospital to peripheral health centers may ensure high follow-up rates.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Tanzania",
- "Humans",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Adult",
- "Rural Population",
- "Aged",
- "Young Adult",
- "Politics",
- "Adolescent",
- "Treatment Adherence and Compliance",
- "Patient Compliance"
- ]
- },
- {
- "PMID": "39595772",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "Risk Factors for Non-Communicable Diseases in Refugees, Asylum Seekers, and Subsidiary Protection Beneficiaries Resettled or Relocated in Portugal Between 2015 and 2020.",
- "Abstract": "Non-communicable diseases, previously thought of as a problem of high-income countries, now coexist in low- and middle-income countries, including the countries of origin for many refugees traveling to Europe. We aimed to describe the prevalence of risk factors for non-communicable diseases among refugees, asylum seekers, and subsidiary protection beneficiaries resettled or relocated in Portugal between 2015 and 2020 and compare these to the prevalence of risk factors in the 12 months before they left their country of origin. A cross-sectional study was conducted between 2019 and 2020 of all refugees, asylum seekers, and subsidiary protection beneficiaries attending a Lisbon, Portugal refugee center. Behavioral and biological risk factors were assessed using the WHO STEPwise modified questionnaire. A descriptive statistical analysis was conducted, which included 80 respondents, mainly men, with an average age of of 30.3 \u00b1 9.8 years. The prevalence of several behavioral risk factors for non-communicable diseases among refugees, asylum seekers, and subsidiary protection beneficiaries was higher at the time of the study than in the 12 months before leaving the country of origin. Differences between men and women were noted in tobacco (49.1% vs. 25.9%) and alcohol use (43.4% vs. 18.5%) in the receiving country. Overweight and obesity also showed differences by gender (7.5% vs. 11.1% and 39.6% vs. 48.1%). The prevalence of suicidal ideation and suicidalplanning was high, and varied from 6.3% and 20% in the country of origin to 16.3% and 38.5% respectively in the receiving country, however the prevalence of suicide attempts was lower in the receiving country (66.7%) compared to the country of origin (100.0%). Information on health and social determinants is critical to identify priorities and increase access to access to gender-specific health and community level interventions, including mental health, to reduce risk factors associated with refugee relocation and resettlement.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Refugees",
- "Male",
- "Female",
- "Risk Factors",
- "Adult",
- "Portugal",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Young Adult",
- "Prevalence",
- "Middle Aged",
- "Adolescent"
- ]
- },
- {
- "PMID": "39592985",
- "Title": "BMC public health",
- "ArticleTitle": "The association between maternal smoking during pregnancy and multimorbidity of non-communicable chronic diseases trajectory in offspring.",
- "Abstract": "This study suggested that the MSDP is associated with almost all transition phases of MNCDs development and increases the mortality risk of MNCDs in offspring who smoke, and these transition trajectories can be largely reduced by smoking cessation among offspring.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Female",
- "Adult",
- "Pregnancy",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Prospective Studies",
- "Adolescent",
- "Male",
- "Young Adult",
- "Aged",
- "Multimorbidity",
- "Prenatal Exposure Delayed Effects",
- "Aged, 80 and over",
- "Smoking",
- "Chronic Disease"
- ]
- },
- {
- "PMID": "39592160",
- "Title": "BMJ open",
- "ArticleTitle": "Physical activity interventions implemented for older people in Sub-Saharan Africa: a scoping review.",
- "Abstract": "This analysis confirms that a structured PA regimen paired with lifestyle education significantly mitigates NCDs in Sub-Saharan Africa's elderly population. Furthermore, it highlights the imperative for further investigation into non-pharmacological strategies, especially those targeting hypertension, diabetes and cognitive health disorders.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Africa South of the Sahara",
- "Exercise",
- "Aged",
- "Noncommunicable Diseases",
- "Randomized Controlled Trials as Topic",
- "Risk Factors"
- ]
- },
- {
- "PMID": "39589015",
- "Title": "Epidemiology (Cambridge, Mass.)",
- "ArticleTitle": "The Contribution of Noncommunicable and Infectious Diseases to the Effect of Depression on Mortality: A Longitudinal Causal Mediation Analysis.",
- "Abstract": "Within the privately insured population of South Africa, MDD is associated with increased mortality. We found that noncommunicable diseases, rather than infectious diseases, are important mediators of the effect of MDD on mortality.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Male",
- "Female",
- "South Africa",
- "Longitudinal Studies",
- "Adult",
- "Middle Aged",
- "Depressive Disorder, Major",
- "Communicable Diseases",
- "Mediation Analysis",
- "Comorbidity",
- "Causality",
- "Aged",
- "Monte Carlo Method",
- "Neoplasms",
- "Cardiovascular Diseases",
- "Young Adult"
- ]
- },
- {
- "PMID": "39584432",
- "Title": "Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit",
- "ArticleTitle": "Experiences and lessons from using digital technology for noncommunicable disease services during the COVID-19 pandemic in the Eastern Mediterranean Region.",
- "Abstract": "DHIs for NCD service provision were implemented during the COVID-19 pandemic in all settings: highmiddle-and low-income countries in the EMR. There is a high potential for incorporating DHIs within health systems to increase access to health services beyond the pandemic. Documentation, regulation and national capacity-building for mainstreaming DHIs in public health services in the EMR are strongly encouraged, based on each country's needs.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "COVID-19",
- "Noncommunicable Diseases",
- "Digital Technology",
- "Middle East",
- "Telemedicine",
- "Mediterranean Region",
- "Pandemics",
- "SARS-CoV-2",
- "Delivery of Health Care"
- ]
- },
- {
- "PMID": "39563350",
- "Title": "BMC medicine",
- "ArticleTitle": "Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime.",
- "Abstract": "Takeaway management zones in England have the potential to meaningfully contribute towards reducing obesity prevalence and associated healthcare burden in the adult population, at the local level and across the rural-urban spectrum.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "England",
- "Adult",
- "Male",
- "Middle Aged",
- "Schools",
- "Female",
- "Obesity",
- "Public Health",
- "Fast Foods",
- "Body Mass Index",
- "Cross-Sectional Studies",
- "Health Care Costs",
- "Restaurants",
- "Noncommunicable Diseases",
- "Quality-Adjusted Life Years",
- "Prevalence"
- ]
- },
- {
- "PMID": "39552939",
- "Title": "Global heart",
- "ArticleTitle": "Lessons Learnt from HIV and Noncommunicable Disease Healthcare Integration in Sub-Saharan Africa.",
- "Abstract": "In sub-Saharan Africa (SSA), a rising burden of noncommunicable diseases (NCDs) coexists with a persistent high burden of human immunodeficiency virus (HIV). Integrating care for chronic conditions is potentially beneficial, but the optimal approach remains unclear. By use of a narrative review of 14 recent case studies from different SSA countries, examples of NCD and HIV healthcare integration were described. Case studies were categorized into three models: integrating NCD care into existing HIV care (",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Africa South of the Sahara",
- "Noncommunicable Diseases",
- "HIV Infections",
- "Delivery of Health Care, Integrated"
- ]
- },
- {
- "PMID": "39552340",
- "Title": "Health policy and planning",
- "ArticleTitle": "Strengthening policy engagement when scaling up interventions targeting non-communicable diseases: insights from a qualitative study across 20 countries.",
- "Abstract": "Policy engagement is an essential component of implementation research for scaling up interventions targeting non-communicable diseases (NCDs). It refers to the many ways that research team members, implementers and policymakers, who represent government decision-making, connect and interact to explore common interests. Well-conducted engagement activities foster co-production, local contextualization and assist in the successful translation of research evidence into policy and practice. We aimed to identify the challenges and facilitators to policy engagement during the early implementation phase of scale-up research studies. This qualitative study was focused on the research projects that were funded through the Global Alliance for Chronic Diseases in the 2019 round. Nineteen project teams opted to participate, with these studies implemented in 20 countries. Forty-three semi-structured stakeholder interviews, representing research, implementation and government were undertaken between August 2020 and July 2021. Transcripts were open-coded using thematic analysis to extract 63 codes which generated 15 themes reflecting both challenges and facilitators to undertaking policy engagement. Knowledge of the local government structures and trusting relationships provided the foundation for successful engagement and were strengthened by the research. Four cross-cutting concepts for engagement were identified and included: (1) the importance of understanding the policy landscape; (2) facilitating a network of suitable policy champions, (3) providing an environment for policy leaders to genuinely contribute to co-creation and (4) promoting two-way learning during researcher-policymaker engagement. We recommend undertaking formative policy analysis to gain a strategic understanding of the policy landscape and develop targeted engagement plans. Through engagement, researchers must facilitate cohesive vision and build a team of policy champions to advocate NCD research within their networks and spheres of influence. Ensuring equitable partnerships is essential for enabling local ownership and leadership. Further, engagement efforts must create a synergistic policymaker-researcher lens to promote the uptake of evidence into policy.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Noncommunicable Diseases",
- "Humans",
- "Qualitative Research",
- "Health Policy",
- "Policy Making",
- "Stakeholder Participation",
- "Interviews as Topic"
- ]
- },
- {
- "PMID": "39548534",
- "Title": "Health research policy and systems",
- "ArticleTitle": "Implementation of national policies and interventions (WHO Best Buys) for non-communicable disease prevention and control in Ghana: a mixed methods analysis.",
- "Abstract": "Ghana has made progress in adopting the WHO Best Buys targeting risk factors of NCDs. However, the country faces contextual barriers to effective implementation. With the retrogression of some measures over time despite making progress in some earlier years, further investigation is needed to identify facilitators for sustained implementation of the WHO Best Buys interventions.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Ghana",
- "Noncommunicable Diseases",
- "Health Policy",
- "World Health Organization",
- "Focus Groups",
- "Stakeholder Participation",
- "Policy Making",
- "Administrative Personnel",
- "Qualitative Research",
- "Public Health",
- "Health Promotion",
- "Health Plan Implementation"
- ]
- },
- {
- "PMID": "39541160",
- "Title": "West African journal of medicine",
- "ArticleTitle": "INTEGRATION OF MENTAL HEALTH INTO MANAGEMENT OF NON-COMMUNICABLE DISEASES IN PRIMARY CARE: A PROJECT REPORT.",
- "Abstract": "Integrating mental health into NCD management is essential for improving patient outcomes. This project demonstrates the necessity of such integration in primary care settings, advocating for policy with detailed guidelines for integrating mental health into NCD care in Ghana.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Primary Health Care",
- "Female",
- "Male",
- "Hypertension",
- "Noncommunicable Diseases",
- "Diabetes Mellitus, Type 2",
- "Ghana",
- "Adult",
- "Middle Aged",
- "Delivery of Health Care, Integrated",
- "Quality Improvement",
- "Depression",
- "Mental Health Services",
- "Anxiety",
- "Mental Disorders",
- "Aged"
- ]
- },
- {
- "PMID": "39530940",
- "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
- "ArticleTitle": "[STUDY OF PREVENTION STRATEGIES FOR SIX RISK FACTORS IN REDUCING MORTALITY FROM NON-COMMUNICABLE DISEASES 25 \u00d7 25].",
- "Abstract": "Non-communicable diseases (NCDs) continue to progress against the background of an increase in risk factors and the emergence of new ones, such as postcovid syndrome. Due in part to this influence, the progression of the atherosclerotic process and deterministic cardiovascular diseases is observed. In this regard, the aggravation of NCDs remains alarming against the background of the influence of six leading risk factors \u00ab25 \u00d7 25\u00bb. The article presents a review of the literature and the conceptual directions of these leading factors as dominant in the development of NCDs. The directions of secondary prevention are considered and the expediency of their early implementation is justified. The presented methodological bibliometric method made it possible to analyze the experience of a number of countries that led to a decrease in the development of NCDs. The methods of bibliographic data search included search queries on the Scopus Web of Sciense, MedLine, The Cochrane Lybrary, PubMed databases. It is noted that achieving even six goals with the correction of risk factors will reduce morbidity and mortality from such four major NCDs as cardiovascular diseases, chronic obstructive pulmonary disease, stomach cancer, diabetes mellitus by 2025 to levels close to the target of \u00ab25 \u00d7 25\u00bb, reducing by 77% the gap between the growth situation or stagnation and trends in the growth of new risk factors.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Cardiovascular Diseases",
- "Secondary Prevention"
- ]
- },
- {
- "PMID": "39522888",
- "Title": "Ageing research reviews",
- "ArticleTitle": "Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990-2021: A population-based study.",
- "Abstract": "The total NCD burden among elderly people in China has been decreasing and changing. Substantial reductions in cardiovascular diseases and chronic respiratory disease have been observed, while rapid increases in mental disorders has also been found. Policies need to be updated to reflect the changing risk landscape. Target interventions should consider age subgroups and sex differences among this population.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "China",
- "Noncommunicable Diseases",
- "Aged",
- "Middle Aged",
- "Male",
- "Female",
- "Incidence",
- "Aged, 80 and over",
- "Disability-Adjusted Life Years",
- "Health Priorities",
- "Global Burden of Disease"
- ]
- },
- {
- "PMID": "39515219",
- "Title": "Public health",
- "ArticleTitle": "Three-year behavioural, health-related quality of life, and body mass index outcomes from the RESPOND randomized trial.",
- "Abstract": "RESPOND protected overall and psychosocial health and had positive effects on BMIz.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Quality of Life",
- "Male",
- "Body Mass Index",
- "Child",
- "Female",
- "Pediatric Obesity",
- "Victoria",
- "COVID-19",
- "Health Behavior",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39514466",
- "Title": "PloS one",
- "ArticleTitle": "The role of illness perception in the physical activity domain of health-promoting lifestyle among patients with non-communicable diseases: A systematic review.",
- "Abstract": "The findings of this review will serve as a guide for healthcare providers in enhancing physical activity adherence among patients with non-communicable diseases through an illness perception approach. This approach can be integrated into clinic consultations and intervention programmes. Future studies are warranted to evaluate the effectiveness of the illness perception approach in promoting physical activity adherence.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Exercise",
- "Noncommunicable Diseases",
- "Health Promotion",
- "Healthy Lifestyle",
- "Perception",
- "Life Style"
- ]
- },
- {
- "PMID": "39511525",
- "Title": "BMC public health",
- "ArticleTitle": "Effectiveness of behaviour change techniques in lifestyle interventions for non-communicable diseases: an umbrella review.",
- "Abstract": "Registered on the International Prospective Register of Systematic Reviews; PROSPERO (CRD42020222832).",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Behavior Therapy",
- "Health Promotion",
- "Life Style",
- "Noncommunicable Diseases",
- "Systematic Reviews as Topic"
- ]
- },
- {
- "PMID": "39496368",
- "Title": "BMJ open",
- "ArticleTitle": "Socioeconomic inequalities and dyslipidaemia in adult population of the Ravansar Non-Communicable Disease Cohort Study: the role of sex and age.",
- "Abstract": "The results highlight the existing inequalities in lipid profiles due to SES, sex and age. Consideration of these factors in interventions and policy decisions is critical to reduce abnormalities and inform future interventions.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Middle Aged",
- "Female",
- "Dyslipidemias",
- "Adult",
- "Cross-Sectional Studies",
- "Aged",
- "Prevalence",
- "Sex Factors",
- "Socioeconomic Factors",
- "Noncommunicable Diseases",
- "Cohort Studies",
- "Age Factors",
- "Social Class",
- "Health Status Disparities",
- "Risk Factors"
- ]
- },
- {
- "PMID": "39494478",
- "Title": "Periodontology 2000",
- "ArticleTitle": "Periodontal disease: A systemic condition.",
- "Abstract": "For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in the oral cavity. Initially, associations of periodontitis with a multitude of noncommunicable diseases were each studied separately, and relationships were shown. The associations of periodontitis with morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory diseases, have been demonstrated. As most such studies were cross-sectional in nature, questions about causality cannot be univocally answered. And periodontitis as an independent risk factor for one systemic disease, becomes even more difficult to assess since recently periodontitis has also been associated with multimorbidity. Periodontitis and many systemic diseases share environmental, lifestyle and genetic risk factors, and share immunopathology. Moreover, suffering from one common noncommunicable disease may increase the susceptibility for another such chronic disease; the systemic effects of one condition may be one of various risk factors for another such disease. The overarching effect of any systemic disease is it causing a pro-inflammatory state in the individual; this has also been shown for periodontitis. Moreover, in periodontitis a prothrombotic state and elevated immunological activity have been shown. As such, when we consider periodontal disease as another systemic disease, it can affect the susceptibility and progression of other systemic diseases, and importantly, vice versa. And with this, it is not surprising that periodontitis is associated with a variety of other noncommunicable diseases. The medical definition of a systemic disease includes diseases that affect different organs and systems. Thus, the aim of this opinion paper is to propose that periodontitis should be considered a systemic disease in its own right and that it affects the individual's systemic condition and wellbeing. The dental and medical profession and researchers alike, should adapt this paradigm shift, advancing periodontal disease out of its isolated anatomical location into the total of chronic noncommunicable diseases, being for some conditions a comorbid disease and, vice versa, comorbidities can affect initiation and progression of periodontal disease.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Risk Factors",
- "Cardiovascular Diseases",
- "Periodontal Diseases",
- "Periodontitis",
- "Disease Susceptibility",
- "Noncommunicable Diseases",
- "Comorbidity"
- ]
- },
- {
- "PMID": "39478581",
- "Title": "The international journal of behavioral nutrition and physical activity",
- "ArticleTitle": "Secular trends and sociodemographic disparities in physical activity among adults in eleven African countries: WHO STEPS 2003-2020.",
- "Abstract": "The prevalence of overall PA among African adults has marginally increased over 17 years. There are still many adults, especially women and people with lower education, not doing well in domain specific PA. Policy and environmental interventions are needed to improve PA and to reduce gender, age, and education disparities in leisure, transport, and occupational PA in African countries.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Adult",
- "Male",
- "Exercise",
- "Female",
- "Middle Aged",
- "Young Adult",
- "Africa",
- "Adolescent",
- "Aged",
- "Socioeconomic Factors",
- "Noncommunicable Diseases",
- "Leisure Activities",
- "Sociodemographic Factors",
- "Surveys and Questionnaires",
- "Sex Factors",
- "Educational Status"
- ]
- },
- {
- "PMID": "39478517",
- "Title": "BMC public health",
- "ArticleTitle": "The association between dietary quality index- international and metabolic risk factors in RaNCD cohort study.",
- "Abstract": "The study found that participants had poor dietary quality, with some favorable metabolic outcomes in the lowest tertile, but concerning associations in the highest tertile, including increased risk for high triglycerides, blood pressure, and obesity. The complex associations suggest that balanced, multifaceted interventions are needed.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Female",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Adult",
- "Prospective Studies",
- "Diet",
- "Risk Factors",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39460821",
- "Title": "Aging clinical and experimental research",
- "ArticleTitle": "Disability trends among elderly Ukrainians in war conditions: a 10-year retrospective study.",
- "Abstract": "Data on primary disability among elderly Ukrainians indicates a significant increase in NCDs-related disability during the war in compare with working population, especially in frontline regions and regions with a high concentration of displaced persons. In this structure of NCDs-related increasing disability, CVD, oncology and musculoskeletal diseases system prevailed.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Ukraine",
- "Retrospective Studies",
- "Aged",
- "Persons with Disabilities",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Aged, 80 and over",
- "Cardiovascular Diseases",
- "Armed Conflicts",
- "Neoplasms",
- "Eastern European People"
- ]
- },
- {
- "PMID": "39458499",
- "Title": "Nutrients",
- "ArticleTitle": "The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease.",
- "Abstract": "Because of their liver-protective effects, nutritionists recommend consuming vegetables, fruits, herbs and spices that provide valuable ingredients with anti-inflammatory and anti-cancer effects. These components should be provided with food and, in the case of probiotics, supplementation appears to be important. As a preventive measure, a diet rich in these nutrients is therefore recommended, as well as one that prevents overweight and other diseases that can result in liver disease.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Liver Diseases",
- "Probiotics",
- "Chronic Disease",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Dietary Fiber",
- "Polyphenols",
- "Food Ingredients",
- "Diet",
- "Spices",
- "Fatty Acids, Omega-3",
- "Dietary Supplements"
- ]
- },
- {
- "PMID": "39458490",
- "Title": "Nutrients",
- "ArticleTitle": "An Innovative One Health Approach: BIOQUALIM, a Transdisciplinary Research Action Protocol-From Cultivated Biodiversity to Human Health Prevention.",
- "Abstract": "BIOQUALIM's transdisciplinary approach will demonstrate the PHD's role in preventing NCDs.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer"
- ],
- "MeshTerms": [
- "Humans",
- "Biodiversity",
- "One Health",
- "Diet, Healthy",
- "Interdisciplinary Research",
- "Noncommunicable Diseases",
- "Diet, Vegetarian",
- "Neoplasms",
- "Quality of Life"
- ]
- },
- {
- "PMID": "39458487",
- "Title": "Nutrients",
- "ArticleTitle": "Global Trends and Research Collaborations on Food and Beverages Warning Labels: A Bibliometric Analysis.",
- "Abstract": "The growth in WL-related research, particularly in Latin America, reflects the increasing implementation of these policies. These results underscore key collaborations and evolving research themes, from food labeling to broader public health impacts, emphasizing the need for continued evaluation of WL effectiveness.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Bibliometrics",
- "Humans",
- "Food Labeling",
- "Beverages",
- "Global Health",
- "Nutrition Policy",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39449123",
- "Title": "BMC medicine",
- "ArticleTitle": "Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases.",
- "Abstract": "The dual insights into age-at-disease-onset and gut microbiota composition in disease emphasize the role of certain biomedical and lifestyle factors, e.g., nutrition quality, in disease prevention and management. Understanding these relationships provides a foundation for developing targeted strategies to mitigate the impact of metabolic and inflammatory diseases through lifestyle modifications and gut health management.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Gastrointestinal Microbiome",
- "Male",
- "Life Style",
- "Female",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Diabetes Mellitus, Type 2",
- "Inflammatory Bowel Diseases",
- "Adult",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Aged",
- "Inflammation",
- "Age of Onset",
- "Cohort Studies"
- ]
- },
- {
- "PMID": "39438053",
- "Title": "BMJ global health",
- "ArticleTitle": "Maintaining non-communicable disease (NCD) services during the COVID-19 pandemic: lessons from Thailand.",
- "Abstract": "The COVID-19 pandemic presented a significant challenge to health systems worldwide, requiring resources to be directed to the pandemic response while also maintaining essential health services. Those with non-communicable diseases (NCDs) are particularly vulnerable to COVID-19, and interrupted care resulting from the pandemic has the potential to worsen morbidity and mortality.We used narrative literature review and key informant interviews between August 2021 and June 2022 to identify how NCD services were impacted during the pandemic and which good practices helped support uninterrupted care.On the background of an existing strong healthcare system, Thailand exhibited strong central coordination of the response, minimised funding interruptions and leveraged existing infrastructure to make efficient use of limited resources, such as through mobilising healthcare workforce. A key intervention has been redesigning NCD systems such as through the 'New Normal Medical Services' initiative. This has promoted digital innovations, including remote self-monitoring, patient risk stratification and alternative medication dispensing. Emphasis has been placed on multidisciplinary, patient-centred and community-centred care.NCD service utilisation has been disrupted during the COVID-19 pandemic; however, newly adapted efforts on top of existing robust systems have been critical to mitigating disruptions. Yet challenges remain, including ensuring ongoing evaluation, adaptation and sustainability of redesign initiatives. This learning offers the potential to further positive health systems change on a wider scale, through sharing knowledge, international collaboration and further refinement of the 'new normal' model.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "COVID-19",
- "Thailand",
- "Noncommunicable Diseases",
- "Delivery of Health Care",
- "SARS-CoV-2",
- "Pandemics"
- ]
- },
- {
- "PMID": "39437825",
- "Title": "Deutsche medizinische Wochenschrift (1946)",
- "ArticleTitle": "[Migration Medicine: infectious and non-infectious diseases].",
- "Abstract": "Approximately one third of the German population has a migration background.According to the federal office for migration, in 2022 around 2,7 million people have taken refuge or have immigrated to Germany, causing major challenges for our health system. In this article, important infectious diseases, and non-infectious conditions like hemoglobinopathies are presented. To date, especially the latter are not common in Germany and must therefore move more into focus when taking care of migrants. Furthermore, new treatment options for hemoglobinopathies have been approved in the last couple of years, starting with the introduction of Luspatercept a few years ago for Beta-Thalassemias and in 2023 the introduction of Voxelotor for sickle cell disease. In 2024 the gene therapy with Exagamglogen-Autotemcel using the CRISPR/Cas molecular scissor was authorized as a new promising treatment for both conditions.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Germany",
- "Communicable Diseases",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39437462",
- "Title": "Patient education and counseling",
- "ArticleTitle": "A scoping review of decision regret in non-communicable diseases: The emerging roles of patient-clinician communication, psychological aspects, and medical outcomes.",
- "Abstract": "Healthcare providers should focus on effective communication and education to personalize care strategies and align treatment decisions with patient expectations. This could ultimately reduce decision regret and improve patient outcomes.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Emotions",
- "Physician-Patient Relations",
- "Communication",
- "Decision Making",
- "Noncommunicable Diseases",
- "Informed Consent"
- ]
- },
- {
- "PMID": "39436669",
- "Title": "Health policy and planning",
- "ArticleTitle": "Balancing realist review outputs with the needs of policymakers and practitioners.",
- "Abstract": "A realist review is a theory-driven approach to synthesizing evidence based on the realist philosophy of science. Realist reviews are conducted to provide the policy and practice community with a rich, detailed and practical understanding of complex social interventions that will likely be of much more use to them when planning and implementing programmes. Robust realist reviews must balance philosophical engagement, methodological rigour and relevance to practice. Nevertheless, they have been criticized for being more philosophically inclined and less methodologically robust, with findings that have little implication for practice. Using the philosophy/epistemology\u2794 methodology\u2794 theory\u2794 practice concept flow, we report how we balanced philosophical principles and practical insights in a recently conducted realist review on participatory practices that impact the benefits of non-communicable disease research and interventions in low- and middle-income countries. If realist reviews are not comprehensible enough for these practitioners, their utility and relevance may suffer from being limited to a specialist cohort of academics. We propose that realist review findings and outputs must be framed and communicated to meaningfully engage practitioners without undertaking translational efforts.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Health Policy",
- "Policy Making",
- "Administrative Personnel",
- "Noncommunicable Diseases",
- "Developing Countries"
- ]
- },
- {
- "PMID": "39432502",
- "Title": "PloS one",
- "ArticleTitle": "Genetic insights into the connection between pulmonary TB and non-communicable diseases: An integrated analysis of shared genes and potential treatment targets.",
- "Abstract": "In this study, we found that all of the hub genes are linked with the 10 drug components, and it was observed that aspirin CTD 00005447 was mostly associated with all the other hub genes. This bio-informatics study may help researchers better understand the cause of PTB and its relationship with NCDs, and eventually, this can lead to exploring effective treatment plans.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Tuberculosis, Pulmonary",
- "Noncommunicable Diseases",
- "Gene Regulatory Networks",
- "Lung Neoplasms",
- "Silicosis",
- "Protein Interaction Maps",
- "Renal Insufficiency, Chronic"
- ]
- },
- {
- "PMID": "39426077",
- "Title": "Public health",
- "ArticleTitle": "The cost of obesity and related NCDs in Brazil: An analysis of hospital admissions, disability retirement benefits, and statutory sick pay.",
- "Abstract": "Obesity prevalence in Brazil implies high direct and indirect costs for the Brazilian government, especially considering circulatory system diseases.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Brazil",
- "Obesity",
- "Male",
- "Female",
- "Adult",
- "Middle Aged",
- "Noncommunicable Diseases",
- "Hospitalization",
- "Body Mass Index",
- "Sick Leave",
- "Prevalence",
- "Cost of Illness",
- "Aged"
- ]
- },
- {
- "PMID": "39421825",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Non-communicable diseases in the world over the past century: a secondary data analysis.",
- "Abstract": "In recent years, nearly all NCDs have shown an increase, yet mortality rates have declined across all regions. Lifestyle can be a major cause of this increase, but advancements in health and medical services, such as screening and treatment, have played a crucial role in improving survival rates.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Female",
- "Prevalence",
- "Incidence",
- "Global Health",
- "Male",
- "Global Burden of Disease",
- "Data Analysis",
- "World Health Organization",
- "Secondary Data Analysis"
- ]
- },
- {
- "PMID": "39418781",
- "Title": "Journal of occupational and environmental medicine",
- "ArticleTitle": "Developing a Job-Exposure Matrix for Sedentary Behavior: A Study Based on the Inpatient Clinico-Occupational Database of Rosai Hospital Group.",
- "Abstract": "The job-exposure matrix provides valuable insights into the health impacts of sedentary behavior in the workplace, underscoring significant disease risks associated with prolonged inactivity.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes"
- ],
- "MeshTerms": [
- "Humans",
- "Sedentary Behavior",
- "Female",
- "Male",
- "Case-Control Studies",
- "Middle Aged",
- "Adult",
- "Occupations",
- "Databases, Factual",
- "Occupational Exposure",
- "Risk Factors",
- "Noncommunicable Diseases",
- "Myocardial Infarction",
- "Sitting Position",
- "Diabetes Mellitus",
- "Aged",
- "Workplace"
- ]
- },
- {
- "PMID": "39418779",
- "Title": "JMIR public health and surveillance",
- "ArticleTitle": "Population-Level Distribution, Risk Factors, and Burden of Mortality and Disability-Adjusted Life Years Attributable to Major Noncommunicable Diseases in Western Europe (1990-2021): Ecological Analysis.",
- "Abstract": "The study findings highlight the substantial burden of NCDs, particularly CVDs and cancer, in Western Europe. This underscores the critical need for targeted interventions and effective implementation of the Action Plan for the Prevention and Control of NCDs to achieve the goal of ensuring healthy lives for all.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Europe",
- "Female",
- "Noncommunicable Diseases",
- "Risk Factors",
- "Disability-Adjusted Life Years",
- "Middle Aged",
- "Aged",
- "Adult",
- "Aged, 80 and over",
- "Adolescent",
- "Neoplasms",
- "Cardiovascular Diseases",
- "Young Adult",
- "Global Burden of Disease",
- "Child",
- "Infant",
- "Cost of Illness",
- "Child, Preschool",
- "Infant, Newborn"
- ]
- },
- {
- "PMID": "39418251",
- "Title": "PloS one",
- "ArticleTitle": "The effect of results-based motivating system on metabolic risk factors of non-communicable diseases: A field trial study.",
- "Abstract": "Involving non-physician health workers and having action plans based on the health needs of the covered population can decrease obesity and overweight in the community. However, longer trials are needed to observe the effects on hypertension and hyperlipidemia.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Middle Aged",
- "Female",
- "Noncommunicable Diseases",
- "Aged",
- "Adult",
- "Obesity",
- "Hypertension",
- "Motivation",
- "Risk Factors",
- "Hyperlipidemias",
- "Iran",
- "Overweight",
- "Prevalence"
- ]
- },
- {
- "PMID": "39416942",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Barriers and facilitators to dissemination of non-communicable diseases research: a mixed studies systematic review.",
- "Abstract": "The protocol of this review was deposited in Open Science Framework (https://doi.org/10.17605/OSF.IO/5QSGD).",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Information Dissemination",
- "Translational Research, Biomedical"
- ]
- },
- {
- "PMID": "39411832",
- "Title": "The British journal of nutrition",
- "ArticleTitle": "Overview of anti-inflammatory diets and their promising effects on non-communicable diseases.",
- "Abstract": "An anti-inflammatory diet is characterised by incorporating foods with potential anti-inflammatory properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red and processed meat, refined carbohydrates and saturated fats are limited. This article explores the effects of an anti-inflammatory diet on non-communicable diseases (NCD), concentrating on the underlying mechanisms that connect systemic chronic inflammation, dietary choices and disease outcomes. Chronic inflammation is a pivotal contributor to the initiation and progression of NCD. This review provides an overview of the intricate pathways through which chronic inflammation influences the pathogenesis of conditions including obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer and cognitive disorders. Through a comprehensive synthesis of existing research, we aim to identify some bioactive compounds present in foods deemed anti-inflammatory, explore their capacity to modulate inflammatory pathways and, consequently, to prevent or manage NCD. The findings demonstrated herein contribute to an understanding of the interplay between nutrition, inflammation and chronic diseases, paving a way for future dietary recommendations and research regarding preventive or therapeutic strategies.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Inflammation",
- "Diet",
- "Anti-Inflammatory Agents",
- "Obesity",
- "Chronic Disease",
- "Diabetes Mellitus, Type 2",
- "Fruit"
- ]
- },
- {
- "PMID": "39408274",
- "Title": "Nutrients",
- "ArticleTitle": "An Overview of Apple Varieties and the Importance of Apple Consumption in the Prevention of Non-Communicable Diseases-A Narrative Review.",
- "Abstract": "Non-communicable diseases such as cardiovascular diseases, cancers, diabetes, and asthma are increasingly common due to factors like industrialization, urbanization, fast-paced life, stress, sedentary lifestyle, and unbalanced diet in the 21st century. These chronic conditions are a global epidemic, being among the top causes of death worldwide. Preventing these diseases through a nutritious diet is crucial, and scientific studies suggest that appropriate fruit intake, particularly apples, can lower the risk of various health issues. Apples, rich in bioactive compounds, vitamins, minerals, and dietary fiber, offer numerous health benefits. Regular consumption of apples helps reduce the risk of atherosclerosis, coronary artery disease, heart attacks, and diabetes, and also provides anti-asthmatic and anti-allergic effects. Apples aid in detoxification, improve digestion, enhance skin, hair, and nail health, and offer protection against cancers, Alzheimer's, and Parkinson's disease. Apples have been a dietary staple for centuries, consumed in various forms like juices, sauces, and ciders. The reviewed article emphasizes the health benefits of apples, highlighting their role in preventing civilization diseases. It also discusses the characteristics of common apple varieties and the impact of thermal processing on their nutritional content.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Malus",
- "Noncommunicable Diseases",
- "Fruit",
- "Nutritive Value",
- "Diet",
- "Diet, Healthy"
- ]
- },
- {
- "PMID": "39408232",
- "Title": "Nutrients",
- "ArticleTitle": "Bioactive Natural and Synthetic Products in Human Health and Diseases: Basic, Preclinical and Clinical Studies.",
- "Abstract": "Since the early 20th century, the increase in non-communicable diseases such as diabetes, heart disease, stroke, and cancer compared to infectious diseases has led to chronic illnesses becoming a leading cause of global morbidity and mortality [...].",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Biological Products",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39407160",
- "Title": "BMC health services research",
- "ArticleTitle": "Readiness of the health system to provide non-communicable disease services in Nepal: a comparison between the 2015 and 2021 comprehensive health facility surveys.",
- "Abstract": "The improvement in NCD service availability does not correspond to the proportional increase in readiness scores, which is crucial for delivering quality care. Regular staff meetings and feedback systems are crucial for improving all services including NCD-related service readiness and should be prioritized by local and provincial governments.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Nepal",
- "Humans",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Health Services Accessibility",
- "Health Care Surveys",
- "Health Facilities",
- "Female",
- "Male"
- ]
- },
- {
- "PMID": "39404094",
- "Title": "Expert review of cardiovascular therapy",
- "ArticleTitle": "Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects.",
- "Abstract": "Due to the fibrinolytic and antithrombotic activity of nattokinase, and more recently added to the anti-inflammatory and antioxidant effects, this enzyme can be used as a new adjuvant therapeutic strategy to mitigate inflammation and oxidative stress in NCDs, including CVD.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Fibrinolytic Agents",
- "Subtilisins",
- "Antioxidants",
- "Oxidative Stress",
- "Anti-Inflammatory Agents",
- "Animals",
- "Inflammation",
- "Cardiovascular Diseases",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39394102",
- "Title": "BMC public health",
- "ArticleTitle": "Recognition of language barriers in comprehending non-communicable disease management among rural elderly people in the DIMAMO surveillance area: a case of AWI-Gen participants.",
- "Abstract": "The study revealed significant misconceptions about diabetes and hypertension, as well as traditional practices like bloodletting, which were perceived to relieve hypertension symptoms. It also identified critical communication barriers, including limited time for health practitioners to explain diagnoses and treatments. The findings emphasize the need for interpreters and culturally sensitive communication strategies to improve health literacy and care. Collaborative efforts between traditional and western health practitioners are recommended to address these issues and enhance community health interventions.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Communication Barriers",
- "Aged",
- "Rural Population",
- "South Africa",
- "Middle Aged",
- "Qualitative Research",
- "Interviews as Topic",
- "Health Knowledge, Attitudes, Practice",
- "Aged, 80 and over"
- ]
- },
- {
- "PMID": "39391944",
- "Title": "The British journal of nutrition",
- "ArticleTitle": "Patterns of beverages consumption and prevalence of non-communicable chronic diseases.",
- "Abstract": "Beverages consumption influences diet quality in general and has been associated with the development of non-communicable chronic diseases (NCCD). We aimed to verify the association between beverage consumption patterns and the prevalence of NCCD. A cross-sectional household and population-based study was conducted with 489 individuals aged 20 years and older. The presence of NCCD (arterial hypertension, diabetes, cancer and hypercholesterolemia) was obtained by self-report, while obesity was diagnosed by measuring body weight, height and waist circumference. Beverage consumption patterns were obtained by principal component analysis. The association between beverages patterns and the prevalence of NCCD was verified using Poisson regression, expressed as prevalence ratio (PR) and adjusted for potential confounding factors. Three beverage patterns were identified: \u2018ultra-processed beverages\u2019, \u2018alcoholic beverages\u2019 and \u2018healthy beverages\u2019. Individuals with greater adherence to the Ultra-processed Beverages Pattern had a 2\u00b777 times higher prevalence of cancer (PR: 3\u00b777; 95 % CI 1\u00b757, 9\u00b707). Higher adherence to the Alcoholic Beverages Pattern was associated with a higher prevalence of obesity (PR: 1\u00b797; 95 % CI 1\u00b713, 3\u00b744). In contrast, individuals in the second tertile of adherence to the Healthy Beverages Pattern had a 39 % lower prevalence of hypercholesterolemia (PR: 0\u00b761; 95 % CI 0\u00b740, 0\u00b792), and individuals in the third tertile had a 10 % lower prevalence of abdominal obesity estimated by the waist-to-height ratio (PR: 0\u00b790; 95 % CI 0\u00b783, 0\u00b797). Beverage consumption patterns may be associated with a higher prevalence of NCCD, regardless of other risk factors. It is therefore important to conduct more studies investigating the impact of beverages patterns on health.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer"
- ],
- "MeshTerms": [
- "Humans",
- "Female",
- "Male",
- "Adult",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Cross-Sectional Studies",
- "Prevalence",
- "Chronic Disease",
- "Beverages",
- "Obesity",
- "Aged",
- "Neoplasms",
- "Hypercholesterolemia",
- "Young Adult",
- "Diet",
- "Alcoholic Beverages",
- "Feeding Behavior"
- ]
- },
- {
- "PMID": "39390457",
- "Title": "BMC public health",
- "ArticleTitle": "Examining noncommunicable diseases using satellite imagery: a systematic literature review.",
- "Abstract": "Researchers have demonstrated they can successfully use satellite imagery data to investigate the world's top NCDs. However, given the rapid increase in satellite technology and artificial intelligence, much of satellite imagery used to address NCDs remains largely untapped. In particular, with most existing studies focusing on high-income countries, future research should use satellite data, to overcome limitations of traditional data, from lower-income countries which have a greater burden of morbidity and mortality from NCDs. Furthermore, creating and refining effective methods to extract and process satellite data may facilitate satellite data's use among scientists studying NCDs worldwide.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Satellite Imagery",
- "Cardiovascular Diseases",
- "Neoplasms"
- ]
- },
- {
- "PMID": "39388415",
- "Title": "PloS one",
- "ArticleTitle": "Noncommunicable disease behavioral risk factors in Sub Saharan Africa: A protocol of systematic review and meta-analysis.",
- "Abstract": "The burden of noncommunicable disease risk factors varies throughout the Sub-Saharan Africa. The review will be essential for both research and policy. The finding may even help to identify settings or subgroups of the population where noncommunicable diseases is of higher concern and help to set prevention priorities, to optimize resource allocation, and guide future research to fill knowledge gaps. The protocol has been registered in PROSPERO (CRD42023431348).",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Africa South of the Sahara",
- "Alcohol Drinking",
- "Exercise",
- "Meta-Analysis as Topic",
- "Noncommunicable Diseases",
- "Prevalence",
- "Risk Factors",
- "Systematic Reviews as Topic",
- "Tobacco Use"
- ]
- },
- {
- "PMID": "39386956",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Non-communicable diseases prevention and control by government ministries in Guyana.",
- "Abstract": "The results showed limitations in transforming multisectoral initiatives into intersectoral collaboration to achieve real integration among the different actors involved, considering the actual context and content. Actions could be more effectively implemented with significant outcomes for NCD control in Guyana.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Guyana",
- "Humans",
- "Noncommunicable Diseases",
- "Qualitative Research",
- "Health Policy",
- "Government",
- "Policy Making"
- ]
- },
- {
- "PMID": "39379988",
- "Title": "BMC medicine",
- "ArticleTitle": "Association of weight change with all-cause and cause-specific mortality: an age-stratified analysis.",
- "Abstract": "Weight loss and excessive weight gain were associated with increased risks of mortality among older adults, while only excessive weight loss was associated with increased risks of mortality among middle-aged adults.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Middle Aged",
- "Male",
- "Female",
- "Aged",
- "Body Mass Index",
- "Cardiovascular Diseases",
- "China",
- "Neoplasms",
- "Age Factors",
- "Cause of Death",
- "Cohort Studies",
- "Proportional Hazards Models",
- "Weight Loss",
- "Weight Gain",
- "Risk Factors",
- "Noncommunicable Diseases"
- ]
- },
- {
- "PMID": "39374955",
- "Title": "BMJ (Clinical research ed.)",
- "ArticleTitle": "Non-communicable diseases: research priorities to mitigate impact of health system shocks.",
- "Abstract": {
- "b": "Amitava Banerjee and colleagues"
- },
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Research",
- "Health Priorities",
- "Biomedical Research"
- ]
- },
- {
- "PMID": "39369417",
- "Title": "JNMA; journal of the Nepal Medical Association",
- "ArticleTitle": "Medication Adherence among Patients with Non-Communicable Diseases in a Tertiary Hospital: A Descriptive Cross-sectional Study.",
- "Abstract": "The study found that less than half of participants fully adhered to prescribed medicine, with forgetfulness identified as a primary cause of non-compliance.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Male",
- "Cross-Sectional Studies",
- "Female",
- "Middle Aged",
- "Tertiary Care Centers",
- "Noncommunicable Diseases",
- "Aged",
- "Adult",
- "Nepal",
- "Health Knowledge, Attitudes, Practice",
- "Assessment of Medication Adherence"
- ]
- },
- {
- "PMID": "39369183",
- "Title": "BMC public health",
- "ArticleTitle": "How likely are Eastern European and central Asian countries to achieve global NCD targets: multi-country analysis.",
- "Abstract": "In most Eastern Europe and Central Asia countries, progress towards achieving NCD global targets is slow, or there's a reverse trend. Further quantitative and qualitative research is needed to understand the underlying reasons. Separate indicators are needed to monitor trends for cancers, diabetes and chronic respiratory diseases.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Middle Aged",
- "Female",
- "Male",
- "Aged",
- "Asia, Central",
- "Adult",
- "Europe, Eastern",
- "Noncommunicable Diseases",
- "Mortality, Premature",
- "Global Health",
- "Global Burden of Disease",
- "Cardiovascular Diseases",
- "Neoplasms",
- "Diabetes Mellitus"
- ]
- },
- {
- "PMID": "39368120",
- "Title": "Annals of Saudi medicine",
- "ArticleTitle": "Estimating the prevalence of select non-communicable diseases in Saudi Arabia using a population-based sample: econometric analysis with natural language processing.",
- "Abstract": "Retrospective design and reliance on electronic health records, which may not capture all cases of NCDs.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes"
- ],
- "MeshTerms": [
- "Humans",
- "Saudi Arabia",
- "Middle Aged",
- "Adult",
- "Male",
- "Female",
- "Noncommunicable Diseases",
- "Natural Language Processing",
- "Prevalence",
- "Retrospective Studies",
- "Hypertension",
- "Aged",
- "Adolescent",
- "Young Adult",
- "Diabetes Mellitus",
- "Electronic Health Records",
- "Obesity",
- "Multimorbidity",
- "Dyslipidemias",
- "Mental Disorders",
- "Logistic Models"
- ]
- },
- {
- "PMID": "39367295",
- "Title": "BMC primary care",
- "ArticleTitle": "Performance of health and wellness centre in providing primary care services in Chhattisgarh, India.",
- "Abstract": "HWCs were able to provide a comprehensive range of primary care services and able to cater to a sizable portion of the rural population's acute and chronic health care needs. The performance was made possible by the adequate availability of medicines, staff, training programmes and tele-consultation linkages. If HWCs in other states are able to reach a similar level of performance, the initiative will prove to be a game changer for equitable primary care in India.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "India",
- "Humans",
- "Primary Health Care",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Comprehensive Health Care",
- "Health Services Needs and Demand"
- ]
- },
- {
- "PMID": "39365121",
- "Title": "Indian journal of dental research : official publication of Indian Society for Dental Research",
- "ArticleTitle": "Dental Research and Noncommunicable Diseases.",
- "Abstract": "",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Dental Research"
- ]
- },
- {
- "PMID": "39363978",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Editorial: A gendered approach for accelerating prevention and control of NCDs.",
- "Abstract": "",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Sex Factors"
- ]
- },
- {
- "PMID": "39356704",
- "Title": "PloS one",
- "ArticleTitle": "Trends and determinants of clustering for non-communicable disease risk factors in women of reproductive age in Nepal.",
- "Abstract": "Clustering of two or more NCD risk factors was higher among women aged \u226530 years, those who are currently married or widowed/divorced/separated, working women, and individuals from the wealthiest socioeconomic groups. A higher burden of risk factors underscores the importance of targeted public health interventions, particularly among women from advantaged socio-economic groups, those of affluent regions, and in the workplace.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Female",
- "Adult",
- "Nepal",
- "Adolescent",
- "Middle Aged",
- "Risk Factors",
- "Young Adult",
- "Hypertension",
- "Obesity",
- "Smoking",
- "Prevalence",
- "Overweight",
- "Cluster Analysis",
- "Noncommunicable Diseases",
- "Health Surveys"
- ]
- },
- {
- "PMID": "39352154",
- "Title": "The Medical journal of Malaysia",
- "ArticleTitle": "Knowledge, attitude and practices of indigenous people towards non-communicable disease in Bera, Malaysia: A community-based study.",
- "Abstract": "This study presented a low-to-moderate percentage of Orang Asli who have good KAP towards NCD. KAP levels were significantly associated with education levels and household income. Hence, improving education and poverty in the Orang Asli community may successively increase the knowledge level, impart a positive attitude towards NCDs, and improve the practice level toward treatment and prevention.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Malaysia",
- "Female",
- "Male",
- "Adult",
- "Cross-Sectional Studies",
- "Health Knowledge, Attitudes, Practice",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Young Adult",
- "Indigenous Peoples",
- "Adolescent",
- "Aged"
- ]
- },
- {
- "PMID": "39352096",
- "Title": "Central European journal of public health",
- "ArticleTitle": "Role of diet in development of non-communicable diseases: focus on gut microbiome.",
- "Abstract": "Findings from this review emphasize the importance of healthy eating habits in the prevention of intestinal dysbiosis and still increasing prevalence and incidence of obesity and other non-communicable diseases.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes type 2"
- ],
- "MeshTerms": [
- "Humans",
- "Gastrointestinal Microbiome",
- "Noncommunicable Diseases",
- "Diet",
- "Obesity",
- "Dysbiosis",
- "Diabetes Mellitus, Type 2",
- "Czech Republic",
- "Inflammation"
- ]
- },
- {
- "PMID": "39344941",
- "Title": "Community dental health",
- "ArticleTitle": "Integrating health screening for non-communicable diseases into dental services: what do we know?",
- "Abstract": "This narrative review describes the impetus for health screening for non-communicable diseases in dental settings and highlights important considerations for evaluating such interventions. Real world cases are presented that showcase health screening interventions implemented in the UK. Non-communicable diseases including diabetes and cardiovascular disease are a global public health challenge. They are largely preventable by implementing lifestyle changes such as healthy eating and participation in physical activity, regular health screening for disease prevention, and/or early initiation of treatment. Hypertension case finding and control is one of the key five areas of focus for adult health, and oral health and diabetes are two of five key clinical areas for children and young people where efforts should be focused to intervene, improve outcomes and reduce inequalities. Links between oral and chronic diseases have been discussed in recent years. Therefore, screening for diabetes and cardiovascular disease has become of greater relevance to the dental profession. There is emerging evidence indicating that screening for the risk factors of cardiovascular diseases and diabetes in dental settings shows promise for improving health outcomes and may offer a cost-effective preventive approach for the detection of diabetes. Real-world services implementing health screening in dental settings have highlighted possibilities for the future and highlight the potential for the role of the dental team in detecting chronic diseases.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Mass Screening",
- "Cardiovascular Diseases",
- "Oral Health",
- "Diabetes Mellitus",
- "United Kingdom"
- ]
- },
- {
- "PMID": "39342408",
- "Title": "Global health research and policy",
- "ArticleTitle": "The gender gap in outpatient care for non-communicable diseases in Mexico between 2006 and 2022.",
- "Abstract": "Over 16\u00a0years of outpatient service utilization by Mexican adults requiring care for NCDs has been characterized by the existence of gender inequalities. Women are more likely either not to receive care or resort to using private outpatient services, often resulting in catastrophic out-of-pocket expenses for them and their families. Such inequalities are exacerbated by the segmented structure of the Mexican health system, which provides health insurance conditional on formal employment participation. These findings should be considered as a key factor in reorienting NCD health policies and programs from a gender perspective.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Mexico",
- "Female",
- "Male",
- "Adult",
- "Middle Aged",
- "Noncommunicable Diseases",
- "Ambulatory Care",
- "Cross-Sectional Studies",
- "Young Adult",
- "Aged",
- "Sex Factors",
- "Healthcare Disparities"
- ]
- },
- {
- "PMID": "39342100",
- "Title": "BMC primary care",
- "ArticleTitle": "Navigating delayed diagnoses, self-neglect, and lost livelihoods: a qualitative exploration of fisherfolk's health perspectives and management of non-communicable diseases in Kerala, India.",
- "Abstract": "This study highlights the NCD-related health-seeking experiences of the fisherfolk community in Kerala, India. Fisherfolk reported self neglect, delayed diagnosis, cost and livelihood constraints owing to the onset of NCDs, even as dual practice and medicine access in the public sector were appreciated. Overall, larger studies and policymaking processes should consider in depth the experiences faced by particular economic groups like fisherfolk, who may face unique health and care-seeking challenges.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "India",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Qualitative Research",
- "Fisheries",
- "Adult",
- "Middle Aged",
- "Delayed Diagnosis",
- "Patient Acceptance of Health Care",
- "Interviews as Topic",
- "Aged",
- "Self Care"
- ]
- },
- {
- "PMID": "39339734",
- "Title": "Nutrients",
- "ArticleTitle": "The Effect of Dietary Types on Gut Microbiota Composition and Development of Non-Communicable Diseases: A Narrative Review.",
- "Abstract": "The current scientific literature consistently highlights the superiority of plant-based and Mediterranean dietary types over the Western diet in promoting gut health and preventing NCDs. Understanding the influence of diet on gut microbiota modulation may pave the way for novel therapeutic strategies.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Gastrointestinal Microbiome",
- "Noncommunicable Diseases",
- "Diet, Mediterranean",
- "Dysbiosis",
- "Diet, Western",
- "Diet, Vegetarian",
- "Diet",
- "Methylamines",
- "Fatty Acids, Volatile"
- ]
- },
- {
- "PMID": "39338107",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "Beyond Numbers: Decoding the Gendered Tapestry of Non-Communicable Diseases in India.",
- "Abstract": "The study emphasizes the importance of gender in the prevalence and management of non-communicable diseases (NCDs) in India, advocating for public health strategies that address gender differences, socio-economic factors, and urban-rural disparities to achieve health equity.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "India",
- "Noncommunicable Diseases",
- "Male",
- "Female",
- "Middle Aged",
- "Adult",
- "Aged",
- "Sex Factors",
- "Longitudinal Studies",
- "Young Adult",
- "Health Surveys",
- "Prevalence",
- "Socioeconomic Factors",
- "Adolescent",
- "Aged, 80 and over"
- ]
- },
- {
- "PMID": "39338026",
- "Title": "International journal of environmental research and public health",
- "ArticleTitle": "A Scoping Review of Non-Communicable Diseases among the Workforce as a Threat to Global Peace and Security in Low-Middle Income Countries.",
- "Abstract": "Non-communicable diseases (NCDs) continue to pose a threat to public health. Although their impact on the workforce is widely recognized, there needs to be more understanding of how NCDs affect peace and security, particularly in low-middle-income countries. To address this, we conducted a scoping review and presented a narrative to explore how NCDs in the workforce threaten peace and security. Out of 570 papers screened, 34 articles, comprising 26 peer review and 8 grey literature, met the study criteria. Our findings reveal that while no study has drawn a direct relationship between NCDs in the workforce in LMICs and peace and security, several studies have demonstrated a relationship between NCDs and economic growth on one hand and economic growth and peace and security on the other. Therefore, using economic growth as a proximal factor, our findings show three pathways that link NCDs in the workforce to peace and security: (i) NCDs lead to low productivity and poor economic growth, which can threaten public peace and security; (ii) NCDs in the workforce can result in long-term care needs, which then puts pressure on public resources and have implications for public expenditure on peace and security; and (iii) household expenditures on caring for a family member with an NCD can destabilize families and create an unfavourable condition that threatens peace and security. This research highlights the dual threat of NCDs to health and security, as they impact human resources and community structures crucial for peace and security. The results underscore the importance of considering the workplace as a strategic setting for NCD prevention, which will have long-term implications for economic growth and peace and security.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Noncommunicable Diseases",
- "Humans",
- "Developing Countries",
- "Economic Development"
- ]
- },
- {
- "PMID": "39334103",
- "Title": "BMC health services research",
- "ArticleTitle": "Examining determinants of control of metabolic syndrome among older adults with NCDs receiving service at NCD Plus clinics: multilevel analysis.",
- "Abstract": "NCDs Plus clinics that provide complete screening for MetS significantly enhance their effectiveness in reducing the proportion of older adults with MetS. In addition, the service should pay attention to older adults who are female, are retired, and take multiple medications to achieve MetS control better. The insights gained from such an analysis could be instrumental in pinpointing the resources necessary to bolster the efficacy of NCD Plus clinics.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Metabolic Syndrome",
- "Female",
- "Male",
- "Aged",
- "Cross-Sectional Studies",
- "Thailand",
- "Multilevel Analysis",
- "Noncommunicable Diseases",
- "Middle Aged",
- "Aged, 80 and over"
- ]
- },
- {
- "PMID": "39333314",
- "Title": "Nature medicine",
- "ArticleTitle": "The economic value of reducing mortality due to noncommunicable diseases and injuries.",
- "Abstract": "With population aging, national health systems face difficult trade-offs in allocating resources. The World Bank launched the Healthy Longevity Initiative to generate evidence for investing in policies that can improve healthy longevity and human capital. As part of this initiative, we quantified the economic value of reducing avoidable mortality from major noncommunicable diseases and injuries. We estimated avoidable mortality-the difference between lowest-achieved mortality frontiers and projected mortality trajectories-for each cause of death, for 2000, 2019 and 2050, and for geographic regions, with high-income countries, India and China considered separately; we applied economic values to these estimates. The economic value of reducing cardiovascular disease avoidable mortality would be large for both sexes in all regions, reaching 2-8% of annual income in 2019. For cancers, it would be 5-6% of annual income in high-income countries and China, and for injuries, it would be around 5% in sub-Saharan Africa and Latin America and the Caribbean. Despite the large uncertainty surrounding our estimates, we offer economic values for reducing avoidable mortality by cause and metrics comparable to annual incomes, which enable multisectoral priority setting and are relevant for high-level policy discussions around budget and resource allocations.",
- "Predictions": [
- "Noncommunicable Diseases",
- "Cancer",
- "Cardiovascular diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Noncommunicable Diseases",
- "Wounds and Injuries",
- "Female",
- "Male",
- "Neoplasms",
- "Cardiovascular Diseases",
- "Cause of Death",
- "Global Health"
- ]
- },
- {
- "PMID": "39324155",
- "Title": "Frontiers in public health",
- "ArticleTitle": "Health-promoting behavior and its determinants towards non-communicable diseases among adult residents of the Gedeo zone, South Ethiopia: the application of the health belief model.",
- "Abstract": "In the study, the mean score of health-promoting behaviors was low. Socio-demographic and economic variables, family history of NCD, perceived health status, knowledge of NCD risk factors, perceived threat, expected outcome, self-efficacy, and cues to action affect health-promoting behaviors. Therefore, the study suggests establishing health promotion programs to increase residents' awareness of health-promoting lifestyles, empower them to adopt healthy lifestyles, and improve health outcomes by increasing self-efficacy, providing education, and creating supportive environments.",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Ethiopia",
- "Male",
- "Female",
- "Adult",
- "Cross-Sectional Studies",
- "Noncommunicable Diseases",
- "Health Belief Model",
- "Middle Aged",
- "Health Behavior",
- "Surveys and Questionnaires",
- "Health Promotion",
- "Young Adult",
- "Health Knowledge, Attitudes, Practice",
- "Adolescent"
- ]
- },
- {
- "PMID": "39308827",
- "Title": "PeerJ",
- "ArticleTitle": "Effect of PM2.5 on burden of mortality from non-communicable diseases in northern Thailand.",
- "Abstract": "High PM2.5 risk was observed in March, with peak PM",
- "Predictions": [
- "Noncommunicable Diseases",
- "Diabetes"
- ],
- "MeshTerms": [
- "Humans",
- "Thailand",
- "Particulate Matter",
- "Noncommunicable Diseases",
- "Female",
- "Male",
- "Air Pollutants",
- "Environmental Exposure",
- "Air Pollution",
- "Hypertension",
- "Diabetes Mellitus",
- "Middle Aged",
- "Adult"
- ]
- },
- {
- "PMID": "39307578",
- "Title": "The Medical journal of Australia",
- "ArticleTitle": "Pregnancy, childbirth and the postpartum period: opportunities to improve lifetime outcomes for women with non-communicable diseases.",
- "Abstract": "",
- "Predictions": [
- "Noncommunicable Diseases"
- ],
- "MeshTerms": [
- "Humans",
- "Pregnancy",
- "Female",
- "Noncommunicable Diseases",
- "Postpartum Period",
- "Parturition",
- "Pregnancy Complications",
- "Australia"
- ]
- }
-]
\ No newline at end of file
diff --git a/testModel/old/test_articles_len.py b/testModel/test_articles_len.py
similarity index 88%
rename from testModel/old/test_articles_len.py
rename to testModel/test_articles_len.py
index 496f967f6..c753b3b17 100644
--- a/testModel/old/test_articles_len.py
+++ b/testModel/test_articles_len.py
@@ -5,7 +5,7 @@ import statistics
# Ajouter le répertoire parent au chemin de recherche
sys.path.append(os.path.abspath(os.path.join(os.path.dirname(__file__), "../")))
-from variables.diseases import DISEASES_LABELS
+from variables.pubmed import NCDS
from variables.articles import LENGTH_CATEGORIES, LENGTH_CATEGORIES_TRESHOLDS
from testModel.utils import get_dataset_filename, get_article_data
from parsers.jsonParser import parseJsonFile
@@ -23,12 +23,10 @@ for length_category in LENGTH_CATEGORIES:
lens = []
-
-
-for disease_label in DISEASES_LABELS:
+for ncd in NCDS:
try:
- filename = get_dataset_filename(disease_label)
+ filename = get_dataset_filename(ncd)
articles = parseJsonFile(f"{DATASET_DIR}/{filename}.json")
except Exception as e:
print(f"Error: {e}")
@@ -47,7 +45,7 @@ for disease_label in DISEASES_LABELS:
if len(text) < length_category_treshold:
nb_articles_categories[LENGTH_CATEGORIES[id]] += 1
added = True
- break;
+ break
if not added:
nb_articles_categories[LENGTH_CATEGORIES[-1]] += 1
@@ -62,5 +60,4 @@ print()
print(f"Longuest: {max(lens)}")
print(f"Shortest: {min(lens)}")
print(f"Mean: {statistics.mean(lens)}")
-print(f"Median: {statistics.median(lens)}")
-
+print(f"Median: {statistics.median(lens)}")
\ No newline at end of file
--
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