diff --git a/model/create_test_data.py b/model/create_test_data.py
index 67b7fb675aac4bd75788a64ba4007a6b76590365..398ea24456a9030721477c4695b2582e66232a86 100644
--- a/model/create_test_data.py
+++ b/model/create_test_data.py
@@ -31,21 +31,21 @@ MESH = [
]
MESH_TERMS = [
- '"Noncommunicable+Diseases"[Mesh]', # NCDs (All)
- '"Diabetes+Mellitus"[Mesh]', # Diabetes (type 1 or 2)
- '"Neoplasms"[Mesh]', # Cancer
- '"Respiratory+Tract+Diseases"[Mesh]', # Chronic respiratory disease
- '"Cardiovascular+Diseases"[Mesh]', # Cardiovascular diseases
- '"Mental+Health"[Mesh]', # Mental Health
- '"Diabetes+Mellitus%2C+Type+1"[Mesh]', # Diabetes type 1
- '"Diabetes+Mellitus%2C+Type+2"[Mesh]' # Diabetes type 2
+ '"Noncommunicable+Diseases"[Mesh:noexp]', # NCDs (All)
+ '"Diabetes+Mellitus"[Mesh:noexp]', # Diabetes (type 1 or 2)
+ '"Neoplasms"[Mesh:noexp]', # Cancer
+ '"Respiratory+Tract+Diseases"[Mesh:noexp]', # Chronic respiratory disease
+ '"Cardiovascular+Diseases"[Mesh:noexp]', # Cardiovascular diseases
+ '"Mental+Health"[Mesh:noexp]', # Mental Health
+ '"Diabetes+Mellitus%2C+Type+1"[Mesh:noexp]', # Diabetes type 1
+ '"Diabetes+Mellitus%2C+Type+2"[Mesh:noexp]' # Diabetes type 2
]
date_min = "2024/01/01"
date_max = "2024/12/31"
for id_term, mesh_term in enumerate(MESH_TERMS):
- data_list = getPubmedData(mesh_term, date_min, date_max, nb_items=1000)
+ data_list = getPubmedData(mesh_term, date_min, date_max, nb_items=10000)
data_store = []
i = 0
@@ -59,12 +59,12 @@ for id_term, mesh_term in enumerate(MESH_TERMS):
data_store.append(data)
i+=1
- if len(data_store) >= 20:
+ if len(data_store) >= 100:
break
filename = LABELS[id_term].replace(" ", "_").replace(",", "").lower()
- with open(f"./data/{filename}.json", "w") as json_file:
+ with open(f"./dataset/{filename}.json", "w") as json_file:
json.dump(data_store, json_file, indent=4)
time.sleep(1)
\ No newline at end of file
diff --git a/model/data/pubmedData.xml b/model/data/pubmedData.xml
index 7b3f887254946d49323b21c411b9105616cd7509..93831bc4500b35c2a911d516b37ee24a560f86b5 100644
Binary files a/model/data/pubmedData.xml and b/model/data/pubmedData.xml differ
diff --git a/model/dataset/cancer.json b/model/dataset/cancer.json
new file mode 100644
index 0000000000000000000000000000000000000000..783ccbd67b0a37540c70368166b84841a91e30bc
--- /dev/null
+++ b/model/dataset/cancer.json
@@ -0,0 +1,2139 @@
+[
+ {
+ "PMID": "39738287",
+ "Title": "Scientific reports",
+ "ArticleTitle": "DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis.",
+ "Abstract": "The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal-Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets. Additionally, we performed experiments with clinical melanoma samples to verify DCLRE1B expression patterns. We also performed pancancer analyses to investigate the diverse roles of DCLRE1B in the biological functions of various cancers. DCLRE1B exhibited distinct expression patterns and played crucial prognostic roles in most tumours. In particular, high expression of DCLRE1B in melanoma was significantly correlated with a poor prognosis and increased malignancy. DCLRE1B was also found to be associated with the immune landscape and various immune biomarkers and regulators. Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. Additionally, DCLRE1B affects various tumour types not only by mediating DNA repair but also by shaping the differential immune microenvironment. In conclusion, our research offers fresh perspectives on the diagnosis and treatment of different types of cancers.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers, Tumor",
+ "Prognosis",
+ "Tumor Microenvironment",
+ "Melanoma",
+ "Gene Expression Regulation, Neoplastic",
+ "Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39738156",
+ "Title": "Nature communications",
+ "ArticleTitle": "The Theranostic Genome.",
+ "Abstract": "Theranostic drugs represent an emerging path to deliver on the promise of precision medicine. However, bottlenecks remain in characterizing theranostic targets, identifying theranostic lead compounds, and tailoring theranostic drugs. To overcome these bottlenecks, we present the Theranostic Genome, the part of the human genome whose expression can be utilized to combine therapeutic and diagnostic applications. Using a deep learning-based hybrid human-AI pipeline that cross-references PubMed, the Gene Expression Omnibus, DisGeNET, The Cancer Genome Atlas and the NIH Molecular Imaging and Contrast Agent Database, we bridge individual genes in human cancers with respective theranostic compounds. Cross-referencing the Theranostic Genome with RNAseq data from over 17'000 human tissues identifies theranostic targets and lead compounds for various human cancers, and allows tailoring targeted theranostics to relevant cancer subpopulations. We expect the Theranostic Genome to facilitate the development of new targeted theranostics to better diagnose, understand, treat, and monitor a variety of human cancers.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Precision Medicine",
+ "Genome, Human",
+ "Theranostic Nanomedicine",
+ "Deep Learning"
+ ]
+ },
+ {
+ "PMID": "39738052",
+ "Title": "Nature communications",
+ "ArticleTitle": "Characterizing mutation-treatment effects using clinico-genomics data of 78,287 patients with 20 types of cancers.",
+ "Abstract": "Evaluating the effectiveness of cancer treatments in relation to specific tumor mutations is essential for improving patient outcomes and advancing the field of precision medicine. Here we represent a comprehensive analysis of 78,287 U.S. cancer patients with detailed somatic mutation profiling integrated with treatment and outcomes data extracted from electronic health records. We systematically identified 776 genomic alterations associated with survival outcomes across 20 distinct cancer types treated with specific immunotherapies, chemotherapies, or targeted therapies. Additionally, we demonstrate how mutations in particular pathways correlate with treatment response. Leveraging the large number of identified predictive mutations, we developed a machine learning model to generate a risk score for response to immunotherapy in patients with advanced non-small cell lung cancer (aNSCLC). Through rigorous computational analysis of large-scale\u00a0clinico-genomic real-world data, this research provides insights and lays the groundwork for further advancements in precision oncology.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mutation",
+ "Neoplasms",
+ "Precision Medicine",
+ "Genomics",
+ "Immunotherapy",
+ "Carcinoma, Non-Small-Cell Lung",
+ "Machine Learning",
+ "Female",
+ "Male",
+ "Treatment Outcome",
+ "Electronic Health Records",
+ "Lung Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39738026",
+ "Title": "Nature communications",
+ "ArticleTitle": "DNA replication initiation drives focal mutagenesis and rearrangements in human cancers.",
+ "Abstract": "The rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in cancer. Sites of replication initiation impede nucleotide excision repair in melanoma and are off-targets for activation-induced deaminase (AICDA) activity in lymphomas. Using ductal pancreatic adenocarcinoma as a cancer model, we demonstrate that the initiation of DNA synthesis is error-prone at G-quadruplex-forming sequences in tumours displaying markers of replication stress, resulting in a previously recognised but uncharacterised mutational signature. Finally, we demonstrate that replication origins serve as hotspots for genomic rearrangements, including structural and copy number variations. These findings reveal replication origins as functional determinants of tumour biology and demonstrate that replication initiation both passively and actively drives focal mutagenesis in cancer genomes.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "DNA Replication",
+ "Mutagenesis",
+ "Pancreatic Neoplasms",
+ "Neoplasms",
+ "Cell Line, Tumor",
+ "DNA Copy Number Variations",
+ "G-Quadruplexes",
+ "Gene Rearrangement",
+ "Carcinoma, Pancreatic Ductal",
+ "DNA Repair",
+ "Mutation"
+ ]
+ },
+ {
+ "PMID": "39738003",
+ "Title": "Nature communications",
+ "ArticleTitle": "An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control.",
+ "Abstract": "CD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as a therapeutic strategy for CD73-expressing cancers. In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045. HB0045 is a 1:1 mixture of two humanized monoclonal IgG1 antibodies (mAbs), HB0038 and HB0039. The cocktail not only harnesses the advantages of its parental mAbs in enzyme inhibition but also shows a significantly greater capability of promoting T cell proliferation in vitro. Structural analyses show that HB0045 effectively locks the CD73 dimer in a \"partially open\" non-active conformation through a double lock mechanism. In various animal models of syngeneic and xenograft tumors, HB0045 inhibits tumor growth more potently than the single mAbs. Collectively, our findings provide functional and structural insights into the mechanism of a CD73-targeting antibody cocktail.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "5'-Nucleotidase",
+ "Animals",
+ "Humans",
+ "Mice",
+ "GPI-Linked Proteins",
+ "Epitopes",
+ "Cell Line, Tumor",
+ "Xenograft Model Antitumor Assays",
+ "Cell Proliferation",
+ "Antibodies, Monoclonal, Humanized",
+ "Neoplasms",
+ "Female",
+ "T-Lymphocytes",
+ "Antibodies, Monoclonal",
+ "Mice, Inbred BALB C",
+ "Combined Antibody Therapeutics"
+ ]
+ },
+ {
+ "PMID": "39737979",
+ "Title": "Nature communications",
+ "ArticleTitle": "Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors.",
+ "Abstract": "Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a strategy for boosting immune response against diverse types of tumors. To induce pyroptosis, we utilize designed tightly regulated gasdermin D variants comprising different pore-forming capabilities and diverse modes of activation, representing a toolbox of ICD inducers. We demonstrate that the electrogenic transfer of ICD effector-encoding plasmids into mouse melanoma tumors when combined with intratumoral expression of cytokines IL-1\u03b2, IL-12, or IL-18, enhanced anti-tumor immune responses. Careful selection of immunostimulatory molecules is, however, imperative as a combination of IL-1\u03b2 and IL-18 antagonized the protective effect of pyroptosis by IFN\u03b3-mediated upregulation of several immunosuppressive pathways. Additionally, we show that the intratumoral introduction of armed pyroptosis provides protection against distant tumors and proves effective across various tumor types without inducing systemic inflammation. Deconstructed inflammasomes thus serve as a powerful, tunable, and tumor-agnostic strategy to enhance antitumor response, even against the most resilient types of tumors.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Pyroptosis",
+ "Animals",
+ "Mice",
+ "Inflammasomes",
+ "Mice, Inbred C57BL",
+ "Humans",
+ "Cell Line, Tumor",
+ "Cytokines",
+ "Melanoma, Experimental",
+ "Interleukin-18",
+ "Interleukin-1beta",
+ "Phosphate-Binding Proteins",
+ "Intracellular Signaling Peptides and Proteins",
+ "Neoplasms",
+ "Female",
+ "Interferon-gamma",
+ "Interleukin-12",
+ "Gasdermins"
+ ]
+ },
+ {
+ "PMID": "39737928",
+ "Title": "Nature communications",
+ "ArticleTitle": "Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo.",
+ "Abstract": "Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly predictive computational methods to model this phenomenon. Here, we introduce HLApollo, a transformer-based model for peptide-MHC-I (pMHC-I) presentation prediction, leveraging the language of peptides, MHC, and source proteins. HLApollo provides end-to-end treatment of MHC-I sequences and deconvolution of multi-allelic data, using a negative-set switching strategy to mitigate misassigned negatives in unlabelled ligandome data. HLApollo shows a 12.65% increase in average precision (AP) on ligandome data and a 4.1% AP increase on immunogenicity test data compared to next-best models. Incorporating protein features from protein language models yields further gains and reduces the need for gene expression measurements. Guided by clinical use, we demonstrate pan-allelic generalization which effectively captures rare alleles in underrepresented ancestries.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Immunotherapy",
+ "Neoplasms",
+ "Histocompatibility Antigens Class I",
+ "Peptides",
+ "Antigen Presentation",
+ "Cancer Vaccines",
+ "Alleles",
+ "Computational Biology"
+ ]
+ },
+ {
+ "PMID": "39737671",
+ "Title": "Archiv der Pharmazie",
+ "ArticleTitle": "The current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids with anticancer therapeutic potential.",
+ "Abstract": "Cancer, characterized by uncontrolled growth and spread of abnormal cells potentially influencing almost all tissues in the body, is one of the most devastating and lethal diseases throughout the world. Chemotherapy is one of the principal approaches for cancer treatment, but multidrug resistance and severe side effects represent the main barriers to the success of therapy, creating a vital need to develop novel chemotherapeutic agents. The 1,2,3-triazole moiety can be conveniently constructed by \"click chemistry\" and could exert diverse noncovalent interactions with various enzymes in cancer cells. Hence, 1,2,3-triazole is one of the most fascinating anticancer pharmacophores. Moreover, 1,2,3-triazole could also serve as a powerful ligation tool for the complex molecular architectures to increase the anticancer efficacy of lead molecules. Notably, 1,2,3-triazole-containing hybrids with intriguing structural variations could target different biological components in cancer cells simultaneously, highlighting their potential in the treatment and eradication of cancer. This review outlines the current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids, inclusive of 1,2,3-triazole-quinazolines, 1,2,3-triazole-quinazolinones, 1,2,3-triazole-quinolines, 1,2,3-triazole-quinolones, 1,2,3-triazole-pyridines, and 1,2,3-triazole-pyrimidines, with anticancer therapeutic potential, and explores their mechanisms of action, critical aspects of design as well as structure-activity relationships (SARs), covering articles published from 2021 to the present, to pave the way for the development of innovative and efficient therapeutic interventions for cancer therapy.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Antineoplastic Agents",
+ "Molecular Structure",
+ "Neoplasms",
+ "Nitrogen",
+ "Structure-Activity Relationship",
+ "Triazoles"
+ ]
+ },
+ {
+ "PMID": "39737633",
+ "Title": "Journal of pediatric hematology/oncology",
+ "ArticleTitle": "Assessment of Antibody Levels and Vaccine-induced Serologic Responses After Completion of Cancer Treatment in Pediatric Patients: A 6-Year Experience in Turkey on HAV, HBV, VZV, and MMR Vaccinations.",
+ "Abstract": "Post-treatment serological vaccine responses in children were lower than anticipated despite multiple doses. Given the potential need for periodic serological assessments and booster vaccinations, long-term follow-ups are planned.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "Male",
+ "Female",
+ "Child, Preschool",
+ "Retrospective Studies",
+ "Turkey",
+ "Adolescent",
+ "Measles-Mumps-Rubella Vaccine",
+ "Neoplasms",
+ "Antibodies, Viral",
+ "Infant",
+ "Vaccination",
+ "Hepatitis B Vaccines",
+ "Chickenpox Vaccine",
+ "Hepatitis A Vaccines",
+ "Follow-Up Studies"
+ ]
+ },
+ {
+ "PMID": "39737568",
+ "Title": "Briefings in bioinformatics",
+ "ArticleTitle": "A comprehensive benchmark study of methods for identifying significantly perturbed subnetworks in cancer.",
+ "Abstract": "Network-based methods utilize protein-protein interaction information to identify significantly perturbed subnetworks in cancer and to propose key molecular pathways. Numerous methods have been developed, but to date, a rigorous benchmark analysis to compare the performance of existing approaches is lacking. In this paper, we proposed a novel benchmarking framework using synthetic data and conducted a comprehensive analysis to investigate the ability of existing methods to detect target genes and subnetworks and to control false positives, and how they perform in the presence of topological biases at both gene and subnetwork levels. Our analysis revealed insights into algorithmic performance that were previously unattainable. Based on the results of the benchmark study, we presented a practical guide for users on how to select appropriate detection methods and protein-protein interaction networks for cancer pathway identification, and provided suggestions for future algorithm development.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Neoplasms",
+ "Humans",
+ "Benchmarking",
+ "Algorithms",
+ "Computational Biology",
+ "Protein Interaction Maps",
+ "Protein Interaction Mapping",
+ "Gene Regulatory Networks"
+ ]
+ },
+ {
+ "PMID": "39737564",
+ "Title": "Briefings in bioinformatics",
+ "ArticleTitle": "Precise identification of somatic and germline variants in the absence of matched normal samples.",
+ "Abstract": "Somatic variants play a crucial role in the occurrence and progression of cancer. However, in the absence of matched normal controls, distinguishing between germline and somatic variants becomes challenging in tumor samples. The existing tumor-only genomic analysis methods either suffer from limited performance or insufficient interpretability due to an excess of features. Therefore, there is an urgent need for an alternative approach that can address these issues and have practical implications. Here, we presented OncoTOP, a computational method for genomic analysis without matched normal samples, which can accurately distinguish somatic mutations from germline variants. Reference sample analysis revealed a 0% false positive rate and 99.7% reproducibility for variant calling. Assessing 2864 tumor samples across 18 cancer types yielded a 99.8% overall positive percent agreement and a 99.9% positive predictive value. OncoTOP can also accurately detect clinically actionable variants and subclonal mutations associated with drug resistance. For the prediction of mutation origins, the positive percent agreement stood at 97.4% for predicting somatic mutations and 95.7% for germline mutations. High consistency of tumor mutational burden (TMB) was observed between the results generated by OncoTOP and tumor-normal paired analysis. In a cohort of 97 lung cancer patients treated with immunotherapy, TMB-high patients had prolonged PFS (P\u2009=\u2009.02), proving the reliability of our approach in estimating TMB to predict therapy response. Furthermore, microsatellite instability status showed a strong concordance (97%) with polymerase chain reaction results, and leukocyte antigens class I subtypes and homozygosity achieved an impressive concordance rate of 99.3% and 99.9% respectively, compared to its tumor-normal paired analysis. Thus, OncoTOP exhibited high reliability in variant calling, mutation origin prediction, and biomarker estimation. Its application will promise substantial advantages for clinical genomic testing.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Germ-Line Mutation",
+ "Neoplasms",
+ "Reproducibility of Results",
+ "Mutation",
+ "Computational Biology",
+ "Genomics",
+ "Lung Neoplasms",
+ "Biomarkers, Tumor"
+ ]
+ },
+ {
+ "PMID": "39737563",
+ "Title": "Briefings in bioinformatics",
+ "ArticleTitle": "Dual-stage optimizer for systematic overestimation adjustment applied to multi-objective genetic algorithms for biomarker selection.",
+ "Abstract": "The selection of biomarker panels in omics data, challenged by numerous molecular features and limited samples, often requires the use of machine learning methods paired with wrapper feature selection techniques, like genetic algorithms. They test various feature sets-potential biomarker solutions-to fine-tune a machine learning model's performance for supervised tasks, such as classifying cancer subtypes. This optimization process is undertaken using validation sets to evaluate and identify the most effective feature combinations. Evaluations have performance estimation error, measurable as discrepancy between validation and test set performance, and when the selection involves many models the best ones are almost certainly overestimated. This issue is also relevant in a multi-objective feature selection process where various characteristics of the biomarker panels are optimized, such as predictive performances and feature set size. Methods have been proposed to reduce the overestimation after a model has already been selected in single-objective problems, but no algorithm existed capable of reducing the overestimation during the optimization, improving model selection, or applied in the more general multi-objective domain. We propose Dual-stage Optimizer for Systematic overestimation Adjustment in Multi-Objective problems (DOSA-MO), a novel multi-objective optimization wrapper algorithm that learns how the original estimation, its variance, and the feature set size of the solutions predict the overestimation. DOSA-MO adjusts the expectation of the performance during the optimization, improving the composition of the solution set. We verify that DOSA-MO improves the performance of a state-of-the-art genetic algorithm on left-out or external sample sets, when predicting cancer subtypes and/or patient overall survival, using three transcriptomics datasets for kidney and breast cancer.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Algorithms",
+ "Biomarkers, Tumor",
+ "Machine Learning",
+ "Neoplasms",
+ "Computational Biology"
+ ]
+ },
+ {
+ "PMID": "39737507",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "Global burden of cancer pattern in 2020 & prediction to 2040 among older adults.",
+ "Abstract": "Background & objectives Cancer is one of the leading causes of death among older adults worldwide. The global burden of cancer among older individuals is increasing due to the ageing population. The increasing burden of cancer among older adults will pose significant social and economic challenges for the delivery of healthcare services. Materials Estimated cancer new cases, deaths, age-standardized truncated incidence and mortality rate per 100,000 for older adults (60 yr or above) were reported using GLOBOCAN 2020 estimates (gco.iarc.fr). Mortality to Incidence ratio (M/I ratio) expressed in percentage by gender and continent was provided. Results Globally, of all cancer cases, 11.3 million cases (representing 62.3%) and 7.5 million deaths (representing 71.2%) were seen among older adults. The top five leading sites of cancer account for 62.2 per cent of older men and 55.9 per cent of older women; however, a widespread geographical variation across world regions is observed. The number of new cancer cases among older adults is expected to rise from 11.3 to 19.8 million (a 75.2% increase) and deaths from 3.99 to 7.3 million (82.8% increase) by 2040. Interpretation & conclusions The expected rise will bring exceptional challenges to healthcare systems, especially in lower- or lower-medium-income countries where resources are limited. Data on cancer among older adults will help health planners and policymakers develop global geriatric cancer control policies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Male",
+ "Female",
+ "Aged",
+ "Global Health",
+ "Middle Aged",
+ "Incidence",
+ "Aged, 80 and over",
+ "Global Burden of Disease"
+ ]
+ },
+ {
+ "PMID": "39737190",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases.",
+ "Abstract": "The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer. Traditional Chinese Medicines (TCMs), which have a long history of use, have been associated with positive effects in disease prevention and treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) and active compounds (e.g., Glabridin, Ginsenoside Rd) can modulate the cGAS-STING signaling pathway, thereby influencing the progression of inflammatory, infectious, or oncological diseases. This review explores the mechanisms by which TCMs interact with the cGAS-STING pathway to regulate immunity, focusing on their roles in infectious diseases, malignancies, and autoimmune disorders.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nucleotidyltransferases",
+ "Signal Transduction",
+ "Membrane Proteins",
+ "Medicine, Chinese Traditional",
+ "Animals",
+ "Neoplasms",
+ "Drugs, Chinese Herbal",
+ "Immunity, Innate",
+ "Autoimmune Diseases"
+ ]
+ },
+ {
+ "PMID": "39737177",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types.",
+ "Abstract": "BCAP31 has the potential to serve as a biomarker for cancer immunology, particularly in relation to immune cell infiltration, and as an indicator of poor prognosis. These findings provide a new perspective that could inform the development of more targeted cancer therapy strategies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Biomarkers, Tumor",
+ "Prognosis",
+ "Gene Expression Regulation, Neoplastic",
+ "Cell Line, Tumor",
+ "Membrane Proteins",
+ "Immunotherapy",
+ "Female",
+ "Male",
+ "Tumor Microenvironment",
+ "Lymphocytes, Tumor-Infiltrating",
+ "DNA Copy Number Variations"
+ ]
+ },
+ {
+ "PMID": "39736787",
+ "Title": "Journal of hematology & oncology",
+ "ArticleTitle": "Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study.",
+ "Abstract": "ClinicalTrials.gov Identifier: NCT04085185.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Antibodies, Monoclonal, Humanized",
+ "Aged",
+ "Adult",
+ "Lymphocyte Activation Gene 3 Protein",
+ "Programmed Cell Death 1 Receptor",
+ "Antineoplastic Combined Chemotherapy Protocols",
+ "Neoplasms",
+ "Immune Checkpoint Inhibitors",
+ "Antigens, CD"
+ ]
+ },
+ {
+ "PMID": "39736754",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "A novel social-network-analysis-based approach for analyzing complex network of actors involved in accessibility of anti-cancer medications\u00a0in Iran.",
+ "Abstract": "This study highlights the importance of complex relationships among various actors and proposes a novel SNA-based approach to analyse them. Regarding the main steps of the proposed approach and the findings, it is imperative for pharmaceutical policy plans to involve a diverse group of experts from the beginning, prioritizing the preferences of stakeholders, and providing a patient-centred approach to prevent the worsening of resource shortages.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Iran",
+ "Health Services Accessibility",
+ "Antineoplastic Agents",
+ "Neoplasms",
+ "Health Policy",
+ "Social Network Analysis",
+ "Policy Making",
+ "Stakeholder Participation",
+ "Surveys and Questionnaires",
+ "Social Networking",
+ "Drug Industry"
+ ]
+ },
+ {
+ "PMID": "39736712",
+ "Title": "BMC medical education",
+ "ArticleTitle": "Patient-centered interprofessional education in cancer care: a systematic scoping review.",
+ "Abstract": "The findings indicate that patient-centered IPE programs effectively promote interprofessional collaboration and enhance clinical competencies in cancer care. Future research should focus on long-term evaluations, address systemic barriers, expand geographical scope, and utilize standardized evaluation frameworks to further improve the design and implementation of patient-centered IPE programs in cancer care.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Patient-Centered Care",
+ "Neoplasms",
+ "Interprofessional Relations",
+ "Interprofessional Education",
+ "Patient Care Team",
+ "Health Personnel",
+ "Cooperative Behavior"
+ ]
+ },
+ {
+ "PMID": "39736689",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
+ "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
+ "Predictions": [
+ "Diabetes",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Neoplasms",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Longitudinal Studies",
+ "Aged",
+ "Proportional Hazards Models",
+ "Diabetes Mellitus",
+ "Risk Factors",
+ "Cardiometabolic Risk Factors",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39736601",
+ "Title": "BMC public health",
+ "ArticleTitle": "Research on health information avoidance behavior and influencing factors of cancer patients-an empirical analysis based on structural equation modeling.",
+ "Abstract": "Sociodemographic factors influencing cancer patients' health information avoidance behaviors include per capita monthly household income, occupation, treatment modality, number of years of smart device use, and number of hours per week reading health information. Self-efficacy and negative emotions mediated the analytic model of health information avoidance behavior in cancer patients, respectively.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Adult",
+ "Self Efficacy",
+ "Surveys and Questionnaires",
+ "Latent Class Analysis",
+ "Aged",
+ "Socioeconomic Factors",
+ "Avoidance Learning"
+ ]
+ },
+ {
+ "PMID": "39736556",
+ "Title": "BMC public health",
+ "ArticleTitle": "Information needs for cancer screening and associated factors of information-seeking behaviour: a qualitative systematic review.",
+ "Abstract": "The list of information needs identified in this review can serve as a reference for health professionals and information service providers before carrying out screening-related work to help the cancer screening participants obtain valuable information.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Information Seeking Behavior",
+ "Early Detection of Cancer",
+ "Qualitative Research",
+ "Neoplasms",
+ "Needs Assessment"
+ ]
+ },
+ {
+ "PMID": "39736554",
+ "Title": "BMC public health",
+ "ArticleTitle": "Pediatric and adolescent cancer disparities in the Middle East and North Africa (MENA) region: incidence, mortality, and survival across socioeconomic strata.",
+ "Abstract": "These findings highlight the need for evidence-based interventions to reduce cancer-related mortality and disease burden among children and adolescents, particularly in low-income countries within the region and for cancer types with the highest mortality rates. Additionally, efforts should focus on establishing registries to provide up-to-date national data on cancer incidence and mortality in countries within the region.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle East",
+ "Male",
+ "Africa, Northern",
+ "Neoplasms",
+ "Incidence",
+ "Female",
+ "Child",
+ "Adolescent",
+ "Child, Preschool",
+ "Infant",
+ "Health Status Disparities",
+ "Socioeconomic Factors",
+ "Young Adult",
+ "Infant, Newborn"
+ ]
+ },
+ {
+ "PMID": "39736368",
+ "Title": "Photodiagnosis and photodynamic therapy",
+ "ArticleTitle": "Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy.",
+ "Abstract": "Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent additional strategies for tumor treatment. Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. Ferroptosis, an iron-dependent type of programmed cell death characterized by accumulation of reactive oxygen species and lipid peroxidation products to lethal levels, has emerged as an attractive target trigger for tumor therapies. Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Ferroptosis",
+ "Photochemotherapy",
+ "Humans",
+ "Photosensitizing Agents",
+ "Reactive Oxygen Species",
+ "Neoplasms",
+ "Lipid Peroxidation"
+ ]
+ },
+ {
+ "PMID": "39736217",
+ "Title": "Biomaterials",
+ "ArticleTitle": "Surface-functionalized bacteria: Frontier explorations in next-generation live biotherapeutics.",
+ "Abstract": "Screening robust living bacteria to produce living biotherapeutic products (LBPs) represents a burgeoning research field in biomedical applications. Despite their natural abilities to colonize bio-interfaces and proliferate, harnessing bacteria for such applications is hindered by considerable challenges in unsatisfied functionalities and safety concerns. Leveraging the high degree of customization and adaptability on the surface of bacteria demonstrates significant potential to improve therapeutic outcomes and achieve tailored functionalities of LBPs. This review focuses on the recent laboratory strategies of bacterial surface functionalization, which aims to address these challenges and potentiate the therapeutic effects in biomedicine. Firstly, we introduce various functional materials that are used for bacterial surface functionalization involving organic, inorganic, and biological materials. Secondly, the methodologies for achieving bacterial surface functionalization are categorized into three primary approaches including covalent bonding, non-covalent interactions, and hybrid techniques, while various advantages and limitations of different modification strategies are compared from multiple perspectives. Subsequently, the current status of the applications of surface-functionalized bacteria in bioimaging and disease treatments, especially in the treatment of inflammatory bowel disease (IBD) and cancer is summarized. Finally, challenges and pressing issues in the development of surface-functionalized bacteria as LBPs are presented.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bacteria",
+ "Surface Properties",
+ "Animals",
+ "Biological Products",
+ "Neoplasms",
+ "Biological Therapy",
+ "Biocompatible Materials"
+ ]
+ },
+ {
+ "PMID": "39736186",
+ "Title": "Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy",
+ "ArticleTitle": "Surface-enhanced Raman spectroscopy as effective tool for detection of sialic acid as cancer biomarker.",
+ "Abstract": "Sialic acid, a negatively charged nine-carbon monosaccharide, is mainly located at the terminal end of glycan chains on glycoproteins and glycolipids of cell surface and most secreted proteins. Elevated levels of sialylated glycans have been known as a hallmark in numerous cancers. As a result, sialic acid acts as a useful and accessible cancer biomarker for early cancer detection and monitoring the disease development during cancer treatment which is crucial in elevating the survival rate. The detection of sialic acid has been done by many tools including surface-enhanced Raman spectroscopy (SERS) which gained incredible attention due to its high selectivity and sensitivity. However, currently, comprehensive reviews of sialic acid detection and imaging as a cancer biomarker using SERS are still lacking. Here, we present the significant breakthroughs in SERS-based detection of sialic acid levels on cells, tissues, and body fluids due to the presence of cancer, different cancer metastasis stages, and in response to the external stimuli. This review covers the SERS substrate and novel SERS strategies, using lectin, boronic acid, metabolic glycan labelling and label-free methods, for sialic acid detection as cancer biomarker. The remaining challenges to detect sialic acid and prospect of future development of SERS for other carbohydrate-based cancer biomarker, for instance fucose, are also discussed.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Spectrum Analysis, Raman",
+ "Humans",
+ "N-Acetylneuraminic Acid",
+ "Biomarkers, Tumor",
+ "Neoplasms",
+ "Animals",
+ "Polysaccharides"
+ ]
+ },
+ {
+ "PMID": "39736017",
+ "Title": "Frontiers in bioscience (Scholar edition)",
+ "ArticleTitle": "Evaluation of Reference Gene Stability for Investigations of Intracellular Signalling in Human Cancer and Non-Malignant Mesenchymal Stromal Cells.",
+ "Abstract": "We analysed and selected stable reference genes for RT-qPCR analysis in the wide panel of cancer cell lines and MSCs. The study provides a reliable tool for future research concerning the expression of genes involved in various intracellular signalling pathways and emphasises the need for careful selection of suitable references before analysing target gene expression.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Mesenchymal Stem Cells",
+ "Neoplasms",
+ "Gene Expression",
+ "Humans",
+ "HeLa Cells",
+ "MCF-7 Cells",
+ "A549 Cells",
+ "Reference Values",
+ "Genes, Essential",
+ "Real-Time Polymerase Chain Reaction"
+ ]
+ },
+ {
+ "PMID": "39735992",
+ "Title": "Frontiers in bioscience (Landmark edition)",
+ "ArticleTitle": "Gene Fusion Detection in Long-Read Transcriptome Datasets from Multiple Cancer Cell Lines.",
+ "Abstract": "The application of our tool to the detection of fusion genes in long-read RNA-seq datasets from two different cancer cell lines demonstrated the detection effectiveness of this tool.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cell Line, Tumor",
+ "Transcriptome",
+ "Neoplasms",
+ "Gene Fusion",
+ "Sequence Analysis, RNA",
+ "Gene Expression Profiling",
+ "Oncogene Proteins, Fusion"
+ ]
+ },
+ {
+ "PMID": "39735988",
+ "Title": "Frontiers in bioscience (Landmark edition)",
+ "ArticleTitle": "The Warburg Effect: Is it Always an Enemy?",
+ "Abstract": "The Warburg effect, also known as 'aerobic' glycolysis, describes the preference of cancer cells to favor glycolysis over oxidative phosphorylation for energy (adenosine triphosphate-ATP) production, despite having high amounts of oxygen and fully active mitochondria, a phenomenon first identified by Otto Warburg. This metabolic pathway is traditionally viewed as a hallmark of cancer, supporting rapid growth and proliferation by supplying energy and biosynthetic precursors. However, emerging research indicates that the Warburg effect is not just a strategy for cancer cells to proliferate at higher rates compared to normal cells; thus, it should not be considered an 'enemy' since it also plays complex roles in normal cellular functions and/or under stress conditions, prompting a reconsideration of its purely detrimental characterization. Moreover, this review highlights that distinguishing glycolysis as 'aerobic' and 'anaerobic' should not exist, as lactate is likely the final product of glycolysis, regardless of the presence of oxygen. Finally, this review explores the nuanced contributions of the Warburg effect beyond oncology, including its regulatory roles in various cellular environments and the potential effects on systemic physiological processes. By expanding our understanding of these mechanisms, we can uncover novel therapeutic strategies that target metabolic reprogramming, offering new avenues for treating cancer and other diseases characterized by metabolic dysregulation. This comprehensive reevaluation not only challenges traditional views but also enhances our understanding of cellular metabolism's adaptability and its implications in health and disease.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Warburg Effect, Oncologic",
+ "Neoplasms",
+ "Glycolysis",
+ "Animals",
+ "Oxidative Phosphorylation",
+ "Energy Metabolism",
+ "Mitochondria",
+ "Cell Proliferation"
+ ]
+ },
+ {
+ "PMID": "39735979",
+ "Title": "Frontiers in bioscience (Landmark edition)",
+ "ArticleTitle": "Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.",
+ "Abstract": [
+ "Functional clustering results showed that aneuploidy and stemness were significantly associated in kidney chromophobe (KICH) and thyroid carcinoma (THCA). And cell metabolism and cell cycle had key effects. Residual analysis indicates superior screening performance by random forest (RF). An aneuploid feature gene set with ",
+ {
+ "i": "MARCKS"
+ }
+ ],
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aneuploidy",
+ "Machine Learning",
+ "Neoplasms",
+ "Myristoylated Alanine-Rich C Kinase Substrate",
+ "Membrane Proteins",
+ "Gene Expression Regulation, Neoplastic",
+ "Cell Proliferation",
+ "Cytoskeletal Proteins"
+ ]
+ },
+ {
+ "PMID": "39735978",
+ "Title": "Frontiers in bioscience (Landmark edition)",
+ "ArticleTitle": "The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype.",
+ "Abstract": "Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within the local environment, TAMs may promote tumor angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit tumor progression via neoantigen presentation, tumoricidal reactive oxygen species generation and pro-inflammatory cytokine secretion. Therefore, TAMs have a pivotal role in determining tumor progression and response to therapy. TAM phenotypes are driven by cytokines and physical cues produced by tumor cells, adipocytes, fibroblasts, pericytes, immune cells, and other cells within the TME. Research has shown that TAMs can be primed by environmental stimuli, adding another layer of complexity to the environmental context that determines TAM phenotype. Innate priming is a functional consequence of metabolic and epigenetic reprogramming of innate cells by a primary stimulant, resulting in altered cellular response to future secondary stimulation. Innate priming offers a novel target for development of cancer immunotherapy and improved prognosis of disease, but also raises the risk of exacerbating existing inflammatory pathologies. This review will discuss the mechanisms underlying innate priming including metabolic and epigenetic modification, its relevance to TAMs and tumor progression, and possible clinical implications for cancer treatment.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Immunity, Innate",
+ "Tumor-Associated Macrophages",
+ "Neoplasms",
+ "Tumor Microenvironment",
+ "Phenotype",
+ "Animals",
+ "Epigenesis, Genetic"
+ ]
+ },
+ {
+ "PMID": "39735682",
+ "Title": "Oncology research",
+ "ArticleTitle": "HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation.",
+ "Abstract": "In summary, our findings highlight HNRNPC as a prognostic marker in various cancers, including liver cancer, and suggest its involvement in shaping the tumor immune microenvironment. These insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression, particularly through immunotherapeutic strategies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers, Tumor",
+ "Disease Progression",
+ "Heterogeneous-Nuclear Ribonucleoprotein Group C",
+ "Neoplasms",
+ "Tumor Microenvironment",
+ "Prognosis",
+ "Gene Expression Regulation, Neoplastic",
+ "Liver Neoplasms",
+ "Cell Line, Tumor",
+ "Cell Proliferation"
+ ]
+ },
+ {
+ "PMID": "39735681",
+ "Title": "Oncology research",
+ "ArticleTitle": "Research advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells.",
+ "Abstract": "Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between ligands and receptors have shown promise in selectively targeting and destroying cancer cells. This review aims to provide a comprehensive overview of various nanoparticle and cell-based drug delivery system types used in cancer research. It covers approved and experimental nanoparticle therapies, including liposomes, micelles, protein-based and polymeric nanoparticles, as well as cell-based DDSs like macrophages, T-lymphocytes, dendritic cells, viruses, bacterial ghosts, minicells, SimCells, and outer membrane vesicles (OMVs). The review also explains the role of TME and its impact on developing smart DDSs in combination therapies and integrating nanoparticles with cell-based systems for targeting cancer cells. By detailing DDSs at different stages of development, from laboratory research to clinical trials and approved treatments, this review provides the latest insights and a collection of valuable citations of the innovative strategies that can be improved for the precise treatment of cancer.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Nanoparticles",
+ "Drug Delivery Systems",
+ "Tumor Microenvironment",
+ "Antineoplastic Agents",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39735536",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors.",
+ "Abstract": "Our data highlighted that NECTIN-4 TAC28-T cells may represent a promising, safe and effective cell therapy for NECTIN-4-overexpressing solid tumors.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "CD28 Antigens",
+ "Mice",
+ "Cell Adhesion Molecules",
+ "Neoplasms",
+ "Lymphocyte Activation",
+ "Cell Line, Tumor",
+ "Immunotherapy, Adoptive",
+ "T-Lymphocytes",
+ "Receptors, Antigen, T-Cell",
+ "Xenograft Model Antitumor Assays",
+ "Female",
+ "Nectins"
+ ]
+ },
+ {
+ "PMID": "39735534",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Abscopal effect of focused ultrasound combined immunotherapy in animal solid tumor model: a systematic reviews and meta-analysis.",
+ "Abstract": "https://www.crd.york.ac.uk/prospero/, identifier CRD42023460710.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Immunotherapy",
+ "Neoplasms",
+ "Combined Modality Therapy",
+ "Humans",
+ "Ultrasonic Therapy",
+ "Disease Models, Animal"
+ ]
+ },
+ {
+ "PMID": "39735533",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.",
+ "Abstract": "Our study demonstrates the potential of urine-based metabolomics for multi-cancer early detection. The approach offers non-invasive cancer screening, promising widespread implementation in population-based programs for early detection and improved outcomes. Further validation and expansion are needed for broader clinical applicability.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Early Detection of Cancer",
+ "Metabolomics",
+ "Male",
+ "Female",
+ "Biomarkers, Tumor",
+ "Middle Aged",
+ "Aged",
+ "Stomach Neoplasms",
+ "Colorectal Neoplasms",
+ "Metabolome",
+ "Adult",
+ "Lung Neoplasms",
+ "Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39734197",
+ "Title": "Epigenetics & chromatin",
+ "ArticleTitle": "Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology.",
+ "Abstract": "DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated. Nanopore sequencing has emerged as a novel technique that can analyze long strands of DNA (long-read sequencing) without chemically treating the DNA. Interestingly, nanopore sequencing can also extract epigenetic status of the nucleotides (including both 5-Methylcytosine and 5-hydroxyMethylcytosine), and a large variety of bioinformatic tools have been developed for improving its detection properties. Out of all genomic regions, long read sequencing provides advantages in studying repetitive elements, which are difficult to characterize through other sequencing methods. Transposable elements are repetitive regions of the genome that are silenced and usually display high levels of DNA methylation. Their demethylation and activation have been observed in many cancers. Due to their repetitive nature, it is challenging to accurately estimate DNA methylation levels within transposable elements using short sequencing technologies. The advantage to sequence native DNA (without PCR amplification biases or harsh bisulfite treatment) and long and ultra long reads coupled with epigenetic states of the DNA allows to accurately estimate DNA methylation levels in transposable elements. This is a big step forward for epigenomic studies, and unsolved questions regarding gene expression and transposable elements silencing through DNA methylation can now be answered.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "5-Methylcytosine",
+ "DNA Methylation",
+ "DNA Transposable Elements",
+ "Epigenesis, Genetic",
+ "Nanopore Sequencing",
+ "Nanopores",
+ "Neoplasms",
+ "Sequence Analysis, DNA"
+ ]
+ },
+ {
+ "PMID": "39733511",
+ "Title": "Bioorganic chemistry",
+ "ArticleTitle": "Protein arginine methyltransferase 7 modulators in disease therapy: Current progress and emerged opportunity.",
+ "Abstract": "Protein arginine methyltransferase 7 (PRMT7) is an essential epigenetic and post-translational regulator in eukaryotic organisms. Dysregulation of PRMT7 is intimately related to multiple types of human diseases, particularly cancer. In addition, PRMT7 exerts multiple effects on cellular processes such as growth, migration, invasion, apoptosis, and drug resistance in various cancers, making it as a promising target for anti-tumor therapeutics. In this review, we initially provide an overview of the structure and biological functions of PRMT7, along with its association with diseases. Subsequently, we summarized the PRMT inhibitors in clinical trials and the co-crystal structural of PRMT7 inhibitors. Moreover, we also focus on recent progress in the design and development of modulators targeting PRMT7, including isoform-selective and non-selective PRMT7 inhibitors, and the dual-target inhibitors based on PRMT7, from the perspectives of rational design, pharmacodynamics, pharmacokinetics, and the clinical status of these modulators. Finally, we also provided the challenges and prospective directions for PRMT7 targeting drug discovery in cancer therapy.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Protein-Arginine N-Methyltransferases",
+ "Humans",
+ "Enzyme Inhibitors",
+ "Neoplasms",
+ "Antineoplastic Agents",
+ "Molecular Structure",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39733440",
+ "Title": "Asian Pacific journal of cancer prevention : APJCP",
+ "ArticleTitle": "Update on Occupational Cancer for Better Cancer Prevention and Control.",
+ "Abstract": "Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations between occupational carcinogens and cancer. Diagnosing occupational cancer and investigating clusters are crucial for understanding its etiology. Prevention at every level- from primary to quarterly prevention- and promotional activities are crucial for exposed workers, often outweighing the importance of treatment, which can be costly. This updated information, as reviewed in this article, and cooperative work with occupational medicine physicians, could contribute to improving clinical practices for better cancer prevention and control.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Occupational Exposure",
+ "Occupational Diseases",
+ "Carcinogens"
+ ]
+ },
+ {
+ "PMID": "39733439",
+ "Title": "Asian Pacific journal of cancer prevention : APJCP",
+ "ArticleTitle": "Deciphering Antigen Processing Machinery (APM) as One of the Determinants for Responsiveness of Affected Patients towards Anticancer Immunotherapy.",
+ "Abstract": "Immunotherapy is one of the rising stars in the field of anticancer regiments. Aimed at reinvigorating immune cytotoxicity, this platform is capable of bulking up memory subsets by which protection against tumors is served. The most commonly applied immunotherapy is immune checkpoint inhibitor (ICIs) which received FDA approval for non-small lung cancer (NSLC) in 2014. The response toward ICI is closely related to the antigen processing machinery (APM) within which antigens are processed prior to loading onto the human leukocyte antigen (HLA) to induce cascade mechanisms for immune clearance. APM allows immune cell infiltration thus strengthens immunogenicity. Impaired components of the APM are frequently found in tumors because tumor progression requires tumor cells to acquire immune recognition evasion. Alterations in tumors' APM result in downregulation of HLA molecules and transformation of antigenic peptide repertoire presented to the T lymphocytes. Interactions of processed antigens (peptide)-HLA complex are critical for successful T cell priming and differentiation into cytotoxic effector cells. The interaction underlies not only ICI-related mechanism but also anticancer immunity in general where T cell subset can induce antitumor recognition only if a proper peptide-HLA complex is present. This feature, unfortunately, is missing in tumors. This Review highlights presentation of tumor-specific antigens to T cells in HLA-restricted manner which leads to their eradication. This is a pivotal point but in most cases is overlooked which might add some volume to the off-target and less functional of anticancer immunotherapy.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Antigen Presentation",
+ "Immunotherapy",
+ "Neoplasms",
+ "Antigens, Neoplasm",
+ "Immune Checkpoint Inhibitors",
+ "HLA Antigens"
+ ]
+ },
+ {
+ "PMID": "39733429",
+ "Title": "Asian Pacific journal of cancer prevention : APJCP",
+ "ArticleTitle": "Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry.",
+ "Abstract": "Cancer incidence level in Northern Tunisia place the country in an intermediate level and projections seem to be worrying. Strengthening prevention, screening and early diagnosis are strongly recommended.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Registries",
+ "Female",
+ "Male",
+ "Tunisia",
+ "Neoplasms",
+ "Incidence",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Adolescent",
+ "Young Adult",
+ "Infant, Newborn",
+ "Infant",
+ "Child",
+ "Child, Preschool",
+ "Follow-Up Studies",
+ "Prognosis",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39733076",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome.",
+ "Abstract": "Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles in cancer progression and therapy resistance. Despite this, the functional diversity of mitochondria across various cancer types remains inadequately characterized. This study seeks to fill this knowledge gap by introducing and validating MitoScore-a novel metric designed to quantitatively assess mitochondrial function across a wide array of cancers. Our investigation evaluates the capacity of MitoScore not only to distinguish between tumor and adjacent normal tissues but also to serve as a predictive marker for clinical outcomes. We analyzed gene expression data from 24 cancer types and corresponding normal tissues using the TCGA database. MitoScore was calculated by summing the normalized expression levels of six mitochondrial genes known to be consistently altered across multiple cancers. Differential gene expression was assessed using DESeq2, with a focus on identifying significant changes in mitochondrial function. MitoScore's associations with tumor proliferation, hypoxia, aneuploidy, and clinical outcomes were evaluated using Spearman's correlation, linear regression, and Kaplan-Meier survival analyses. MitoScore was significantly higher in tumor tissues compared to normal tissues across most cancer types (p\u2009<\u20090.001). It positively correlated with tumor proliferation rates (r\u2009=\u20090.46), hypoxia scores (r\u2009=\u20090.61), and aneuploidy (r\u2009=\u20090.44), indicating its potential as a marker of aggressive tumor behavior. High MitoScore was also associated with poorer prognosis in several cancer types, suggesting its utility as a predictive biomarker for clinical outcomes. This study introduces MitoScore, a metric for mitochondrial activity often elevated in tumors and linked to poor prognosis. It correlates positively with hypoxia and negatively with stromal and immune infiltration, highlighting mitochondria's role in the tumor microenvironment. MitoScore's association with genomic instability, such as aneuploidy, suggests mitochondrial dysfunction contributes to cancer progression. Despite challenges in mitochondrial-targeted therapies, MitoScore may identify tumors responsive to such treatments, warranting further research for clinical application.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Mitochondria",
+ "Gene Expression Regulation, Neoplastic",
+ "Biomarkers, Tumor",
+ "Prognosis",
+ "Genomics",
+ "Cell Proliferation",
+ "Kaplan-Meier Estimate"
+ ]
+ },
+ {
+ "PMID": "39732961",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Pan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers.",
+ "Abstract": "Polyomavirus enhancer activator 3 (PEA3), an ETS transcription factor, has been documented to regulate the development and metastasis of human cancers. Nonetheless, a thorough analysis examining the relationship between the PEA3 subfamily members and tumour development, prognosis, and the tumour microenvironment (TME) across various cancer types has not yet been conducted. The expression profiles and prognostic significance of the PEA3 subfamily were evaluated using data from the GEO, TCGA, and PrognoScan databases, in conjunction with COX regression analyses and the Kaplan-Meier Plotter. Furthermore, the relationships between PEA3 subfamily expression, stemness scores, tumor microenvironments, immune subtypes, and drug susceptibility across multiple cancer types were explored. We found that ETV1, ETV4 and ETV5 are highly expressed in cancer, and their biological functions are synergistic. In the prognostic analysis of the Cancer Genome Atlas, the PEA3 subfamily genes were found to be associated with the prognosis of multiple cancers such as Lung adenocarcinoma (LUAD), Liver hepatocellular carcinoma (LIHC), etc., and marked a worse prognosis at different endpoints. In addition, it was significantly correlated with the stromal and immune scores of pan-cancer, and also significantly associated with the RNA stemness score and DNA stemness score of pan-cancer. Expression levels of the PEA3 subfamily genes correlate with immune subtypes of LIHC, LUAD, and Lung squamous cell carcinoma. We also found a variety of drugs with positive and negative associations of ETV1, ETV4 and ETV5. These findings elucidate the role of the PEA3 subfamily gene as a biomarker for carcinogenesis and cancer progression, offering valuable insights for future research into the PEA3 subfamily gene as a potential therapeutic target across various cancer types.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers, Tumor",
+ "Transcription Factors",
+ "Proto-Oncogene Proteins c-ets",
+ "Prognosis",
+ "Neoplasms",
+ "Gene Expression Regulation, Neoplastic",
+ "Tumor Microenvironment",
+ "Adenovirus E1A Proteins",
+ "DNA-Binding Proteins",
+ "Kaplan-Meier Estimate",
+ "Gene Expression Profiling"
+ ]
+ },
+ {
+ "PMID": "39732661",
+ "Title": "BMC infectious diseases",
+ "ArticleTitle": "Onco-mNGS facilitates rapid and precise identification of the etiology of fever of unknown origin: a single-centre prospective study in North China.",
+ "Abstract": "Onco-mNGS is an ideal rapid diagnostic aid to assist improving the early diagnostic efficiency of FUO-associated diseases.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Fever of Unknown Origin",
+ "Prospective Studies",
+ "Female",
+ "Male",
+ "China",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Neoplasms",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39732529",
+ "Title": "Trends in immunology",
+ "ArticleTitle": "Targeting molecular pathways to control immune checkpoint inhibitor toxicities.",
+ "Abstract": "Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It examines key immune cells, such as T cell subsets and myeloid cells, which are instrumental in irAE pathogenesis, alongside an in-depth analysis of cytokine signaling [interleukin (IL)-6, IL-17, IL-4), interferon \u03b3 (IFN-\u03b3), IL-1\u03b2, tumor necrosis factor \u03b1 (TNF-\u03b1)], integrin-mediated interactions [integrin subunits \u03b1ITGA)4 and ITGB7], and microbiome-related factors that contribute to irAE pathology. This exploration of modifiable pathways uncovers new opportunities to mitigate irAEs by using available antibodies (Abs) that target key inflammatory molecules across tumor types, while ideally preserving the antitumor efficacy of ICIs.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Immune Checkpoint Inhibitors",
+ "Neoplasms",
+ "Animals",
+ "Signal Transduction",
+ "Cytokines",
+ "Immunotherapy",
+ "Molecular Targeted Therapy"
+ ]
+ },
+ {
+ "PMID": "39732497",
+ "Title": "BMJ open",
+ "ArticleTitle": "Co-designing a low-intensity psychological therapy for fear of recurrence in psychosis using translational learning from fear of recurrence in oncology: protocol for intervention development for future testing in a feasibility study.",
+ "Abstract": "The INDIGO study received ethical approval from East Midlands-Nottingham 2 Research Ethics Committee (24/EM/0124). The study received independent peer review prior to funding. This co-design study is expected to lead to a future feasibility study and, if indicated, a randomised controlled trial.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Feasibility Studies",
+ "Fear",
+ "Schizophrenia",
+ "Psychotic Disorders",
+ "Neoplasms",
+ "Psychosocial Intervention",
+ "Neoplasm Recurrence, Local",
+ "Research Design"
+ ]
+ },
+ {
+ "PMID": "39732363",
+ "Title": "Life sciences",
+ "ArticleTitle": "CAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach.",
+ "Abstract": "Our approach contributes to a better understanding of immune cell migration and the influence of mechanical constraints, which will allow the testing of new ways to improve CAR-T cell trafficking into solid tumours. Therefore, our study revealed that the migratory behaviour of CAR-T cells differs from that of T cells under confined conditions and that biomechanical cues, such as cell deformability caused by confinement, can influence the correct infiltration of immune cells into solid tumours during the immune response.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "T-Lymphocytes",
+ "Cell Movement",
+ "Immunotherapy, Adoptive",
+ "Tumor Microenvironment",
+ "Receptors, Chimeric Antigen",
+ "Neoplasms",
+ "Microfluidics",
+ "Lab-On-A-Chip Devices",
+ "Cell Line, Tumor"
+ ]
+ },
+ {
+ "PMID": "39732216",
+ "Title": "International journal of pharmaceutics",
+ "ArticleTitle": "Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals.",
+ "Abstract": "Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Antioxidants",
+ "Flavonoids",
+ "Nanoparticles",
+ "Animals",
+ "Neuroprotective Agents",
+ "Cosmeceuticals",
+ "Neoplasms",
+ "Biological Availability",
+ "Nanoparticle Drug Delivery System",
+ "Antineoplastic Agents",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39732178",
+ "Title": "Biochimica et biophysica acta. Reviews on cancer",
+ "ArticleTitle": "Research progress of mitochondria and cytoskeleton crosstalk in tumour development.",
+ "Abstract": "During tumour progression, organelle function undergoes dramatic changes, and crosstalk among organelles plays a significant role. Crosstalk between mitochondria and other organelles such as the endoplasmic reticulum and cytoskeleton has focussed attention on the mechanisms of tumourigenesis. This review demonstrates an overview of the molecular structure of the mitochondrial-cytoskeletal junction and its biological interactions. It also presents a detailed and comprehensive description of mitochondrial-cytoskeletal crosstalk in tumour occurrence and development, including tumour cell proliferation, apoptosis, autophagy, metabolic rearrangement, and metastasis. Finally, the application of crosstalk in tumour therapy, including drug combinations and chemoresistance, is discussed. This review offers a theoretical basis for establishing mitochondrial-cytoskeletal junctions as therapeutic targets, and offers novel insights into the future management of malignant tumours.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mitochondria",
+ "Neoplasms",
+ "Cytoskeleton",
+ "Animals",
+ "Autophagy",
+ "Apoptosis",
+ "Cell Proliferation"
+ ]
+ },
+ {
+ "PMID": "39732132",
+ "Title": "Human immunology",
+ "ArticleTitle": "Shedding light on the role of complement C4 activation in cancer.",
+ "Abstract": "Complement C4 is a key component in the activation of classical and lectin complement pathways, which are observed in both animal tumor models and cancer patients. While its role in autoimmune disorders has been extensively studied, the functions of complement C4 and its activation in cancer have received inadequate consideration. Recent studies have detected C4 activation in animal tumor models and cancer patients, with its fragment C4d found in cancer tissues and lymph nodes. Elevated C4d levels could be a useful biomarker for detecting various cancers. This review aims to summarize recent developments on the role of complement C4 activation in promoting an immunosuppressive tumor microenvironment, thereby supporting tumor progression and metastasis; C4d as a biomarker; and its potential as a target for cancer immunotherapy. We also conduct a critical evaluation of methods used to measure complement C4 and its activation products, highlighting possible pitfalls and areas for improvement in existing research.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Animals",
+ "Complement Activation",
+ "Tumor Microenvironment",
+ "Complement C4",
+ "Biomarkers, Tumor",
+ "Immunotherapy",
+ "Complement C4b",
+ "Peptide Fragments"
+ ]
+ },
+ {
+ "PMID": "39731918",
+ "Title": "Cell reports. Medicine",
+ "ArticleTitle": "Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.",
+ "Abstract": "Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N\u00a0= 54). Single-cell RNA-seq and T\u00a0cell receptor sequencing (TCR-seq) reveal that CD8",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers, Tumor",
+ "Immunotherapy",
+ "Tumor Microenvironment",
+ "CD8-Positive T-Lymphocytes",
+ "Leukocytes, Mononuclear",
+ "Male",
+ "Female",
+ "Receptors, Antigen, T-Cell",
+ "Neoplasms",
+ "Middle Aged",
+ "Transcriptome"
+ ]
+ },
+ {
+ "PMID": "39731836",
+ "Title": "Biomaterials advances",
+ "ArticleTitle": "Anti-miR21-conjugated DNA nanohydrogel for enhanced cancer therapy.",
+ "Abstract": "MicroRNAs (miRNAs) are non-coding, endogenous small single-stranded RNA molecules involved in post-transcriptional regulation of gene expression. It has been demonstrated that dysregulation of miRNA plays a major role in tumor formation, proliferation, and metastasis. Therefore, the delivery of anti-miRNA oligonucleotides to block the activity of these oncogenic miRNAs is a high-potential anti-cancer therapy approach. In particular, miRNA-21 (miR-21) can be an excellent target as it is an oncogenic miRNA that is upregulated in various cancers including glioblastoma, breast cancer, and colon cancer. However, anti-miRNAs are unstable in the physiological environment and have low cell membrane permeability, making it difficult to accumulate at certain concentrations to have anti-cancer effects within cancer cells. To overcome these difficulties, we developed anti-miR-21 functionalized DNA hydrogel (amiR-21 Dgel). We confirmed the improved physiological stability of amiR-21 Dgel in vitro, and observed that it blocked up to 96.6\u00a0% of miR-21 in HeLa cells, and reduced cell viability down to 77.9\u00a0% for 72\u00a0h. In particular, RT-qPCR analysis demonstrated that blocking of miR-21 induces increased mRNA expression of the tumor suppressor genes, PTEN and PDCD4 by 6.23- and 6.87-fold, respectively. In addition, the Dgel can act as a drug delivery vehicle, intercalating anticancer drugs such as doxorubicin (Dox) to be delivered into cells. DOX, an anticancer drug, showed a synergistic anticancer effect with amiR-21, which was delivered together. We expect that this approach will be a convenient to optimization and highly effective strategy for anticancer therapy employing antisense miRNAs.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "MicroRNAs",
+ "Hydrogels",
+ "HeLa Cells",
+ "DNA",
+ "Doxorubicin",
+ "PTEN Phosphohydrolase",
+ "Cell Survival",
+ "Neoplasms",
+ "Apoptosis Regulatory Proteins",
+ "RNA-Binding Proteins",
+ "Antineoplastic Agents",
+ "Gene Expression Regulation, Neoplastic"
+ ]
+ },
+ {
+ "PMID": "39731788",
+ "Title": "European journal of medicinal chemistry",
+ "ArticleTitle": "Recent progress in the development of peptide-drug conjugates (PDCs) for cancer therapy.",
+ "Abstract": "Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides, linkers, and payloads, which possess favorable targeting capability and can deliver enough payloads to the tumor sites with minimized impact on healthy tissues. However, only a few PDCs have been approved for clinical use so far. To advance the research on PDCs, this review summarizes the approved PDCs, and PDCs in clinical and preclinical stages based on the payload types. Additionally, the biological activity and pharmacokinetic properties of preclinical PDCs are detailedly described. Lastly, the challenges and future development directions of PDCs are discussed. This review aims to inspire insights into the development of PDCs for cancer treatment.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Antineoplastic Agents",
+ "Peptides",
+ "Animals",
+ "Drug Development",
+ "Molecular Structure"
+ ]
+ },
+ {
+ "PMID": "39731736",
+ "Title": "Bioinformatics (Oxford, England)",
+ "ArticleTitle": "VarNMF: non-negative probabilistic factorization with source variation.",
+ "Abstract": "Code is available at https://github.com/Nir-Friedman-Lab/VarNMF.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Algorithms",
+ "Neoplasms",
+ "Genomics"
+ ]
+ },
+ {
+ "PMID": "39731651",
+ "Title": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
+ "ArticleTitle": "Effect of Qigong exercise on quality of life and cortisol in patients with cancer: a non-randomized controlled trial.",
+ "Abstract": "Six-month Guolin Qigong could improve quality of life, physical function, and pain, and have a beneficial effect on the well-being of cancer patients. Further studies are warranted to confirm these results.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "Female",
+ "Male",
+ "Hydrocortisone",
+ "Qigong",
+ "Middle Aged",
+ "Neoplasms",
+ "Aged",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39731471",
+ "Title": "Iranian journal of immunology : IJI",
+ "ArticleTitle": "Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein.",
+ "Abstract": "These immunotoxin structures showed therapeutic potential against GRP78-expressing cancers, making them suitable candidates for targeted therapy pending in vivo studies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Endoplasmic Reticulum Chaperone BiP",
+ "Single-Domain Antibodies",
+ "Recombinant Fusion Proteins",
+ "Immunotoxins",
+ "Apoptosis",
+ "Exotoxins",
+ "Animals",
+ "Heat-Shock Proteins",
+ "Cell Line, Tumor",
+ "Camelus",
+ "Breast Neoplasms",
+ "Female",
+ "ADP Ribose Transferases",
+ "Bacterial Toxins",
+ "HEK293 Cells",
+ "Pseudomonas aeruginosa Exotoxin A",
+ "Neoplasms",
+ "MCF-7 Cells",
+ "Virulence Factors"
+ ]
+ },
+ {
+ "PMID": "39731178",
+ "Title": "Journal of experimental & clinical cancer research : CR",
+ "ArticleTitle": "Cancer Organoids as reliable disease models to drive clinical development of novel therapies.",
+ "Abstract": "On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled \"Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies,\" took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells interacting within their microenvironments. These models address critical unmet needs in precision medicine, particularly in aiding clinical decision-making. The rapid development of these human tissue avatars has enabled advanced modeling of cellular alterations in disease states and the screening of compounds to uncover novel therapeutic pathways.Throughout the event, distinguished speakers shared their expertise and research findings, illustrating how organoids are transforming our understanding of treatment resistance, metastatic dynamics, and the interaction between tumors and the surrounding microenvironment.This conference served as a pivotal opportunity to strengthen international collaborations and spark innovative translational approaches. Its goal was to accelerate the shift from preclinical research to clinical application, paving the way for increasingly personalized and effective cancer therapies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Organoids",
+ "Neoplasms",
+ "Tumor Microenvironment",
+ "Precision Medicine",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39731135",
+ "Title": "Molecular cancer",
+ "ArticleTitle": "Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade.",
+ "Abstract": "The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immune microenvironment. Here, we performed an extensive clinical and bioinformatic analysis to explore the association between KDM5 mutation and tumor immunity and its impact on the outcomes in pan-cancer immunotherapy. In 2943 patients across 12 tumor types treated with immune checkpoint inhibitors, KDM5-mutant tumors were associated with favorable overall survival (hazard ratio, 0.72; 95% confidence interval, 0.59-0.87; P\u2009=\u20090.004) and objective response rate (41.7% vs. 26.8%; P\u2009=\u20090.001). Further multi-omics analysis revealed KDM5 mutation was related to boosted tumor immunogenicity, enriched infiltration of immune cells, and improved immune responses. In summary, KDM5 mutation indicates enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade. These results have implication for treatment decision-making and developing immunotherapy for personalized care.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Immune Checkpoint Inhibitors",
+ "Neoplasms",
+ "Mutation",
+ "Tumor Microenvironment",
+ "Histone Demethylases",
+ "Biomarkers, Tumor",
+ "Prognosis",
+ "Immunotherapy"
+ ]
+ },
+ {
+ "PMID": "39731127",
+ "Title": "Molecular cancer",
+ "ArticleTitle": "Advances in A-to-I RNA editing in cancer.",
+ "Abstract": "RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine deaminase acting on RNA (ADAR) in double-stranded RNA (dsRNA). With advancements in RNA sequencing technologies, the role of A-to-I modification in cancer has garnered increasing attention. Research indicates that the levels and specific sites of A-to-I editing are significantly altered in many malignant tumors, correlating closely with tumor progression. This editing occurs in both coding and noncoding regions of RNA, influencing signaling pathways involved in cancer development. These modifications can either promote or suppress cancer progression through several mechanisms, including inducing non-synonymous amino acid mutations, altering the immunogenicity of dsRNAs, modulating mRNA interactions with microRNAs (miRNAs), and affecting the splicing of circular RNAs (circRNAs) as well as the function of long non-coding RNAs (lncRNAs). A comprehensive understanding of A-to-I RNA editing is crucial for advancing the diagnosis, treatment, and prognosis of human cancers. This review explores the regulatory mechanisms of A-to-I editing in cancers and examines their potential clinical applications. It also summarizes current research, identifies future directions, and highlights potential therapeutic implications.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "RNA Editing",
+ "Neoplasms",
+ "Inosine",
+ "Adenosine",
+ "Animals",
+ "Gene Expression Regulation, Neoplastic",
+ "Adenosine Deaminase",
+ "Biomarkers, Tumor",
+ "MicroRNAs"
+ ]
+ },
+ {
+ "PMID": "39731088",
+ "Title": "BMC palliative care",
+ "ArticleTitle": "Specialized palliative outpatient clinic care involvement associated with decreased end-of-life hospital costs in cancer patients, a single center study.",
+ "Abstract": "Our results provide first indications that a contact to specialist palliative care in an outpatient clinic may reduce end-of-life hospital care costs in hospital-deceased cancer patients.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Retrospective Studies",
+ "Palliative Care",
+ "Aged",
+ "Middle Aged",
+ "Neoplasms",
+ "Terminal Care",
+ "Aged, 80 and over",
+ "Finland",
+ "Hospital Costs",
+ "Ambulatory Care Facilities",
+ "Registries",
+ "Adult",
+ "Ambulatory Care"
+ ]
+ },
+ {
+ "PMID": "39731068",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.",
+ "Abstract": "Among the general American population, baseline CMI levels exhibited an L-shaped nonlinear relationship with all-cause mortality, and the threshold value was 0.98. What's more, CMI may become an effective indicator for CVD, cancer, and all-cause mortality prediction. Further investigation is essential to confirm our findings.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "Neoplasms",
+ "Adult",
+ "Aged",
+ "Triglycerides",
+ "Cause of Death",
+ "Waist Circumference",
+ "Cholesterol, HDL",
+ "Proportional Hazards Models",
+ "Kaplan-Meier Estimate",
+ "Body Mass Index",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39731019",
+ "Title": "BMC bioinformatics",
+ "ArticleTitle": "AEGAN-Pathifier: a data augmentation method to improve cancer classification for imbalanced gene expression data.",
+ "Abstract": "AEGAN-Pathifier shows improved performance on the imbalanced datasets GSE25066, GSE20194, BRCA and Liver24. Results from various classifiers indicate that AEGAN-Pathifier has good generalization capability.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Algorithms",
+ "Deep Learning",
+ "Gene Expression Profiling",
+ "Computational Biology",
+ "Databases, Genetic"
+ ]
+ },
+ {
+ "PMID": "39730977",
+ "Title": "Journal of the Egyptian National Cancer Institute",
+ "ArticleTitle": "Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges.",
+ "Abstract": "Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics. The benefits and drawbacks of certain green synthesis techniques, such as plant-mediated, microorganism-mediated, and other environmentally friendly processes, are discussed. Moreover, a thorough discussion is given of CuNPs' biological uses, including their antibacterial activity, anticancer potential, drug transport, and bioimaging capabilities. Furthermore, difficulties and prospects for the application of green-synthesised CuNPs in biomedicine are discussed.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Copper",
+ "Humans",
+ "Metal Nanoparticles",
+ "Green Chemistry Technology",
+ "Neoplasms",
+ "Antineoplastic Agents",
+ "Drug Resistance, Neoplasm"
+ ]
+ },
+ {
+ "PMID": "39730928",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.",
+ "Abstract": "Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time. More important, the neurotransmitter serotonin was encapsulated on the surface of ZIF-8/DOX by oxidative polymerization, which can effectively avoid the premature leakage of DOX in the blood circulation. And the formed polyserotonin shell has superior photothermal conversion performance, as well as the adsorption property of polyserotonin shell was utilized to load imiqumod. When FM@IQ/PST&ZIF-8/DOX entered the tumor tissue, the surface modified folate molecules can specifically bind to the folate receptors on the surface of tumor cells to improve FM@IQ/PST&ZIF-8/DOX uptake by tumor cells. In vitro and in vivo results showed that FM@IQ/PST&ZIF-8/DOX nanoplatform could generate a large amount of heat under near-infrared light irradiation, and then induce the apoptosis of tumor cells, release tumor associated antigens, and effectively solve the problem of tumor heterogeneity. In addition, the loaded imiquimod could effectively improve the immunosuppressive microenvironment, enhance the body's anti-tumor immune response, to inhibit tumor metastasis and recurrence. Therefore, the novel FM@IQ/PST&ZIF-8/DOX nanoplatform designed in this research can not only achieve controllable and precise drug release, but also it is expected to become a promising new strategy for tumor treatment and provide corresponding inspiration for the later research and development of environment-responsive drugs.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Doxorubicin",
+ "Animals",
+ "Mice",
+ "Humans",
+ "Cell Line, Tumor",
+ "Immunotherapy",
+ "Neoplasms",
+ "Drug Delivery Systems",
+ "Nanoparticles",
+ "Tumor Microenvironment",
+ "Biomimetics",
+ "Imiquimod",
+ "Serotonin",
+ "Antineoplastic Agents",
+ "Combined Modality Therapy",
+ "Mice, Inbred BALB C"
+ ]
+ },
+ {
+ "PMID": "39730772",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Mediating and moderating factors between stigma and adaptability to return to work for cancer survivors.",
+ "Abstract": "Adaptability to return to work is a process by which cancer survivors(CSs) utilize accessible resources to reconstruct themselves. While the stigma, financial situation and social support are known to influence their adaptability to return to work, the mechanisms by which these factors work remain unclear. This study proposes a moderated mediation model to signify a pathway linking stigma to the adaptability to return to work. Data were analyzed using the PROCESS macro for R version 4.3.1. A total of 238 CSs, aged between 18 and 60 years (73.5% female), of whom 42.1% had returned to work, completed the ARTWS, SIS, COST-PROM, SSRS, HeLMS. Stigma had a negative associations on the adaptability to return to work. Both financial toxicity and social support mediated the relationship between stigma and the adaptability to return to work. Health literacy moderated both the direct pathway and the second half of the pathway mediated by financial toxicity. Specifically, the negative effects of stigma and financial toxicity on the adaptability to return to work were significantly attenuated when health literacy levels were high. CSs with higher health literacy may not experience excessive stigma, and experience less financial toxicity than those with lower health literacy. CSs possessing greater social support will be more effective in utilizing external resources to buffer the influence of financial toxicity, and thus adapt better to work.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cancer Survivors",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Return to Work",
+ "Social Stigma",
+ "Social Support",
+ "Adolescent",
+ "Young Adult",
+ "Adaptation, Psychological",
+ "Health Literacy",
+ "Neoplasms",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39730706",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Death and hospital contact in a cohort from Thybor\u00f8n-Harbo\u00f8re an environmentally contaminated site in Denmark.",
+ "Abstract": "We studied mortality and hospital contact in people from Thybor\u00f8n-Harbo\u00f8re, an environmentally contaminated fishing community on the Danish West Coast. The population and a comparison group from other fishing communities on the Danish West Coast were identified from historical data in the Central Population Register. All persons were followed up for death and hospital contacts to March 2023. Event rates were compared with Poisson regression; adjusted rate ratios (aRR); and 95% confidence interval (CI). The old cohort included inhabitants in Thybor\u00f8n-Harbo\u00f8re in 1968-1970 before pollution was controlled; 4914 persons/2485 deaths. All-cause mortality, aRR 1.06 (95% CI 1.01-1.11), and cancer mortality, aRR 1.17 (95% CI 1.05-1.30), were elevated; especially for kidney cancer aRR 1.82 (95% CI 1.07-3.12). Hospital contacts were elevated for psychiatric disorders; with an aRR of 4.07 (95% CI 1.41-11.72) for anxiety in men. As there is still considerable concern in the area about possible health consequences from stored chemicals, we included also a new cohort of newborn and immigrants to the area in 1990-2006; 2933 persons/302 deaths. All-cause mortality, aRR 1.26 (1.11-1.43) (men 1.15 and women 1.44), and cancer mortality, aRR 1.47 (95% CI 1.14-1.89) were elevated. Hospital contacts were elevated for ischemic heart disease/heart attack and indicated for autism/obsessive compulsory disorder in boys. In conclusion, mortality data confirmed incidence data of excess kidney cancer in the old cohort. The new cohort had a generally elevated mortality, possibly indicating selective immigration from other parts of Denmark. However, the new cohort is still relatively young, and the mortality pattern needs to be monitored.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Denmark",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Cohort Studies",
+ "Environmental Pollution",
+ "Young Adult",
+ "Child, Preschool",
+ "Infant, Newborn",
+ "Environmental Exposure",
+ "Adolescent",
+ "Child",
+ "Infant",
+ "Aged, 80 and over",
+ "Neoplasms",
+ "Cause of Death"
+ ]
+ },
+ {
+ "PMID": "39730699",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Comparative evaluation of feature reduction methods for drug response prediction.",
+ "Abstract": "Personalized medicine aims to tailor medical treatments to individual patients, and predicting drug responses from molecular profiles using machine learning is crucial for this goal. However, the high dimensionality of the molecular profiles compared to the limited number of samples presents significant challenges. Knowledge-based feature selection methods are particularly suitable for drug response prediction, as they leverage biological insights to reduce dimensionality and improve model interpretability. This study presents the first comparative evaluation of nine different knowledge-based and data-driven feature reduction methods on cell line and tumor data. Our analysis employs six distinct machine learning models, with a total of more than 6,000 runs to ensure a robust evaluation. Our findings indicate that transcription factor activities outperform other methods in predicting drug responses, effectively distinguishing between sensitive and resistant tumors for seven of the 20 drugs evaluated.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Machine Learning",
+ "Antineoplastic Agents",
+ "Precision Medicine",
+ "Neoplasms",
+ "Cell Line, Tumor"
+ ]
+ },
+ {
+ "PMID": "39730637",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Characterising immune-related adverse events in different types of cancer among Chinese patients receiving immune checkpoint inhibitors.",
+ "Abstract": "Immune checkpoint inhibitors (ICIs) have been approved for monotherapy and combined therapy with chemotherapy and/or radiotherapy in China since 2018. The number of patients receiving ICIs has significantly increased in recent years, and the collection and analysis of this data are crucial for a comprehensive understanding of their clinical outcomes and adverse effects. The effects of ICIs may vary among different ethnic groups, and there is a lack of such data in the Chinese population. This study aimed to investigate the occurrence rate of various types of immune-related adverse events (irAEs) of ICIs in cancer survivors with different types of cancer and explore the associated risk factors. Demographic data, cancer type, dosage, Eastern Cooperative Oncology Group Performance Score (ECOG-PS), and details of irAEs were collected from 120 participants who underwent ICI treatment. Descriptive statistics were used to summarise the patient population characteristics, while t-tests and Chi-square tests assessed associations between variables. Multiple logistic regression evaluated the relationships between independent variables and the likelihood of experiencing irAEs. The results indicated that the occurrence of less severe G1 and G2 irAEs was 25%, while more severe G3 to G5 irAEs accounted for 5.8% of the total. Among the irAEs, skin toxicity had the highest incidence rate (14.2%), followed by gastrointestinal toxicity (6.7%), and endocrine toxicity had the lowest incidence rate of 2.5%. The multiple logistic regression model revealed that patients with ECOG-PS\u2009\u2265\u20092 are over five times more likely to experience irAEs compared to those with lower ECOG-PS (OR: 5.03, 95% CI: 1.05-24.17). Additionally, patients with cancer stage IV have 11.47 times the odds of experiencing irAEs (OR: 11.47, 95% CI: 1.05-24.17). In conclusion, a substantial proportion of patients receiving ICIs experienced irAEs. Patients with an ECOG-PS score of \u2265\u20092 and advanced cancer stage are at increased risk for these events, necessitating close monitoring by healthcare professionals. The identification of skin and gastrointestinal toxicities as the most common irAEs revealed the need for targeted education for the patients and their carers to recognise and manage these issues. Furthermore, our findings, in conjunction with existing literature, may guide future research on predictive modelling for high-risk patients receiving ICIs.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Aged",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "China",
+ "Drug-Related Side Effects and Adverse Reactions",
+ "East Asian People",
+ "Immune Checkpoint Inhibitors",
+ "Neoplasms",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39730328",
+ "Title": "Nature communications",
+ "ArticleTitle": "A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy.",
+ "Abstract": "Immune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate the efficacy of the therapy. The gut microbiome's influence on ICB efficacy is of particular interest due to its modifiability through various interventions. However, gut microbiome biomarkers for ICB response have been inconsistent across different studies. Here, we identify TANB77, an uncultured and distinct bacterial clade, as the most consistent responder-enriched taxon through meta-analysis of ten independent ICB recipient cohorts. Traditional taxonomy fails to distinguish TANB77 from unrelated taxa, leading to its oversight. Mice with higher gut TANB77 abundance, either naturally or through transplantation, show improved response to anti-PD-1 therapy. Additionally, mice injected with TANB77-derived pilin-like protein exhibit improved anti-PD-1 therapy response, providing in vivo evidence for the beneficial role of the pilin-like protein. These findings suggest that pilins from the TANB77 order may enhance responses to ICB therapy across diverse cohorts of cancer patients.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Gastrointestinal Microbiome",
+ "Mice",
+ "Immunotherapy",
+ "Humans",
+ "Immune Checkpoint Inhibitors",
+ "Female",
+ "Fimbriae Proteins",
+ "Programmed Cell Death 1 Receptor",
+ "Neoplasms",
+ "Mice, Inbred C57BL",
+ "Bacteria",
+ "Cell Line, Tumor",
+ "Male"
+ ]
+ },
+ {
+ "PMID": "39730320",
+ "Title": "Psycho-oncology",
+ "ArticleTitle": "Post-Treatment Cancer Survivors' Experience of Social Reintegration: A Systematic Review and Meta-Synthesis.",
+ "Abstract": "This study synthesized qualitative evidence related to social reintegration among post-treatment cancer survivors. Cancer survivors took active measures for social reintegration. In turn, social reintegration also had a positive consequence on cancer survivors. Survivors had internal and external obstacles and needs in the process of social reintegration. Therefore, practitioners should identify obstacles and needs for social reintegration and develop targeted intervention programs to facilitate the social reintegration of survivors.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cancer Survivors",
+ "Social Support",
+ "Neoplasms",
+ "Qualitative Research",
+ "Social Adjustment",
+ "Social Interaction"
+ ]
+ },
+ {
+ "PMID": "39730153",
+ "Title": "BMJ open",
+ "ArticleTitle": "Exploring the status of online social support for older adults with cancer: a scoping review protocol.",
+ "Abstract": "No ethical approval is needed. The findings will be published in a peer-reviewed journal and presented at conferences.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Social Support",
+ "Aged",
+ "COVID-19",
+ "SARS-CoV-2",
+ "Online Social Networking",
+ "Research Design",
+ "Scoping Reviews As Topic"
+ ]
+ },
+ {
+ "PMID": "39729927",
+ "Title": "Cancer genetics",
+ "ArticleTitle": "Machine learning analysis of CD4+ T cell gene expression in diverse diseases: insights from cancer, metabolic, respiratory, and digestive disorders.",
+ "Abstract": "CD4",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "CD4-Positive T-Lymphocytes",
+ "Neoplasms",
+ "Machine Learning",
+ "Digestive System Diseases",
+ "Metabolic Diseases",
+ "Respiratory Tract Diseases",
+ "Gene Expression Profiling",
+ "Respiration Disorders"
+ ]
+ },
+ {
+ "PMID": "39729909",
+ "Title": "Redox biology",
+ "ArticleTitle": "Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer.",
+ "Abstract": "The increase in early-stage cancers, particularly gastrointestinal, breast and kidney cancers, has been linked to lifestyle changes such as consumption of processed foods and physical inactivity, which contribute to obesity and diabetes - major cancer risk factors. Conventional treatments such as chemotherapy and radiation often lead to severe long-term side effects, including secondary cancers and tissue damage, highlighting the need for new, safer and more effective therapies, especially for young patients. Weak electromagnetic fields (WEMF) offer a promising non-invasive approach to cancer treatment. While WEMF have been used therapeutically for musculoskeletal disorders for decades, their role in oncology is still emerging. WEMFs affect multiple cellular processes through mechanisms such as the radical pair mechanism (RPM), which alters reactive oxygen species (ROS) levels, mitochondrial function, and glycolysis, among others. This review explores the potential of WEMF in conjunction with reactive oxygen species as a cancer therapy, highlighting WEMFs selective targeting of cancer cells and its non-ionizing nature, which could reduce collateral damage compared to conventional treatments. In addition, synchronization of WEMF with circadian rhythms may further enhance its therapeutic efficacy, as has been demonstrated in other cancer therapies.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Reactive Oxygen Species",
+ "Humans",
+ "Neoplasms",
+ "Magnetic Fields",
+ "Animals",
+ "Mitochondria",
+ "Electromagnetic Fields"
+ ]
+ },
+ {
+ "PMID": "39729775",
+ "Title": "Biomaterials",
+ "ArticleTitle": "In situ production and precise release of bioactive GM-CSF and siRNA by engineered bacteria for macrophage reprogramming in cancer immunotherapy.",
+ "Abstract": "In the immunosuppressive tumor microenvironment (TME), tumor-associated macrophages (TAMs) predominantly exhibit an immunosuppressive M2 phenotype, which facilitates tumor proliferation and metastasis. Although current strategies aimed at reprogramming TAMs hold promise, their sustainability and effectiveness are limited due to repeated injections. Herein, a bacterial therapy platform containing two engineered strains was developed. One strain was engineered to produce and secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) to promote M2-like TAMs repolarization to M1-like TAMs, while the other strain was designed to secrete small interfering RNA (siRNA) targeting signal regulatory protein \u03b1 (SIRP\u03b1). The two strains can continuously and efficiently produce bioactive therapeutic agents in situ, exerting a sustained and synergistic therapeutic effect in TAMs to inhibit tumor growth. To enhance treatment efficacy, optogenetic strategy was implemented to effectively control the production of GM-CSF, and outer membrane vesicles (OMVs) produced by engineered bacteria were utilized to protect the siRNA from degradation in the external environment. The experimental results indicated that the bacterial therapy platform could continuously produce and release bioactive GM-CSF and SIRP\u03b1 siRNA, exhibiting significant therapeutic activity. In vivo experiments further demonstrated that this platform showed more sustained and stable therapeutic effects compared to conventional drug therapies. Additionally, the combination of these two engineered strains yielded the highest ratio of M1/M2 TAMs (0.80) and the lowest ratio of F4/80",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Granulocyte-Macrophage Colony-Stimulating Factor",
+ "Animals",
+ "RNA, Small Interfering",
+ "Immunotherapy",
+ "Mice",
+ "Macrophages",
+ "Cellular Reprogramming",
+ "Mice, Inbred C57BL",
+ "Neoplasms",
+ "Tumor Microenvironment",
+ "Cell Line, Tumor",
+ "Humans",
+ "Tumor-Associated Macrophages",
+ "Female",
+ "RAW 264.7 Cells"
+ ]
+ },
+ {
+ "PMID": "39729479",
+ "Title": "PloS one",
+ "ArticleTitle": "The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells.",
+ "Abstract": "Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene expression levels represent the average measure from multiple cell populations. Alternatively, single cell RNA sequencing can dive into unique cell populations transcriptome, facilitating the identification of specific targets. Here, we generated Tumor-Infiltrating regulatory T cells (TI-Tregs) and exhausted T cells (Tex) gene signatures from a single cell RNA-seq pan-cancer T cell atlas. To overcome noise and sparsity inherent to single cell transcriptomics, we then propagated the gene signatures by diffusion in a protein-protein interaction network using the Patrimony high-throughput computing platform. This methodology enabled the refining of signatures by rescoring genes based on their biological connectivity and shed light not only on processes characteristics of TI-Treg and Tex development and functions but also on their immunometabolic specificities. The combined use of single cell transcriptomics and network propagation may thus represent an innovative and effective methodology for the characterization of cell populations of interest and eventually the development of new therapeutic strategies in immuno-oncology.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Single-Cell Analysis",
+ "Lymphocytes, Tumor-Infiltrating",
+ "Neoplasms",
+ "RNA-Seq",
+ "T-Lymphocytes, Regulatory",
+ "Transcriptome",
+ "Gene Expression Profiling",
+ "Protein Interaction Maps",
+ "Sequence Analysis, RNA",
+ "Gene Regulatory Networks",
+ "Gene Expression Regulation, Neoplastic",
+ "Single-Cell Gene Expression Analysis"
+ ]
+ },
+ {
+ "PMID": "39729462",
+ "Title": "PloS one",
+ "ArticleTitle": "Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis.",
+ "Abstract": "MIRV has significant therapeutic effects in solid tumors, especially when combined with BEV. In platinum-tolerant tumors, the efficacy of MIRV is also considerable. Overall, MIRV is relatively safe in solid tumors, and adverse reactions are relatively rare and mild.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Maytansine",
+ "Immunoconjugates",
+ "Antibodies, Monoclonal, Humanized",
+ "Neoplasms",
+ "Female",
+ "Folate Receptor 1",
+ "Progression-Free Survival"
+ ]
+ },
+ {
+ "PMID": "39729341",
+ "Title": "Biomacromolecules",
+ "ArticleTitle": "Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors.",
+ "Abstract": "The efficacy of tumor-targeted therapeutics, engineered to engage specific cellular receptors to promote accumulation and penetration, is strongly influenced by the carrier's affinity for its target and the valency of binding molecules incorporated into the carrier. Previous research has primarily focused on improving targeting by augmenting the number of binding proteins on the carrier, inadvertently raising avidity without isolating the individual effects of binding strength and valency. Herein, we precisely evaluate the impact of multivalency on tumor targeting with a recombinant approach to independently control valency, avidity, and size. Our findings reveal that constructs with equivalent binding strength exhibit comparable receptor engagement and tumor extravasation, regardless of valency. Moreover, excessive avidity adversely affected tumor accumulation and penetration, with the highest-avidity construct showing diminished exposure. These results indicate that overall binding strength, not valency, is the primary determinant of tumor targeting, providing valuable insights for designing effective macromolecular drug carriers.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Animals",
+ "Mice",
+ "Neoplasms",
+ "Drug Carriers",
+ "Cell Line, Tumor",
+ "Macromolecular Substances",
+ "Protein Binding",
+ "Drug Delivery Systems"
+ ]
+ },
+ {
+ "PMID": "39729330",
+ "Title": "Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association",
+ "ArticleTitle": "A Scoping Review of Chemotherapy-induced Peripheral Neuropathy-Related Gait Abnormalities in Children With Cancer.",
+ "Abstract": "Relevant research on the topic of CIPN-related gait abnormalities in children with cancer identifies knowledge gaps and the need for more studies on the effects of CIPN on children.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Peripheral Nervous System Diseases",
+ "Child",
+ "Neoplasms",
+ "Gait Disorders, Neurologic",
+ "Antineoplastic Agents",
+ "Gait",
+ "Range of Motion, Articular",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39729314",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Radiologist Involvement in Radiation Oncology Peer Review: A Systematic Review and Meta-Analysis.",
+ "Abstract": "In this systematic review and meta-analysis of radiation oncology PR of contoured targets, radiologist involvement in peer review was associated with a significant increase in the rate of total and clinically meaningful changes to the RT targets with no change in minor change rates. These results support the value of interdisciplinary collaboration with radiology during RT planning.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Radiation Oncology",
+ "Radiologists",
+ "Peer Review",
+ "Peer Review, Health Care",
+ "Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39727835",
+ "Title": "Biosensors",
+ "ArticleTitle": "Application of Fluorescence- and Bioluminescence-Based Biosensors in Cancer Drug Discovery.",
+ "Abstract": "Recent advances in drug discovery have established biosensors as indispensable tools, particularly valued for their precision, sensitivity, and real-time monitoring capabilities. The review begins with a brief overview of cancer drug discovery, underscoring the pivotal role of biosensors in advancing cancer research. Various types of biosensors employed in cancer drug discovery are then explored, with particular emphasis on fluorescence- and bioluminescence-based technologies such as FRET, TR-FRET, BRET, NanoBRET, and NanoBiT. These biosensors have enabled breakthrough discoveries, including the identification of Celastrol as a novel YAP-TEAD inhibitor through NanoBiT-based screening, and the development of TR-FRET assays that successfully identified Ro-31-8220 as a SMAD4R361H/SMAD3 interaction inducer. The integration of biosensors in high throughput screening and validation for cancer drug compounds is examined, highlighting successful applications such as the development of LATS biosensors that revealed VEGFR as an upstream regulator of the Hippo signaling pathway. Real-time monitoring of cellular responses through biosensors has yielded invaluable insights into cancer cell signaling pathways, as demonstrated by NanoBRET assays detecting RAF dimerization and HiBiT systems monitoring protein degradation dynamics. The review addresses challenges linked to biosensor applications, such as maintaining stability in complex tumor microenvironments and achieving consistent sensitivity in HTS applications. Emerging trends are discussed, including integrating artificial intelligence and advanced nanomaterials for enhanced biosensor performance. In conclusion, this review offers a comprehensive analysis of fluorescence- and bioluminescence-based biosensor applications in the dynamic cancer drug discovery field, presenting quantitative evidence of their impact and highlighting their potential to revolutionize targeted cancer treatments.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Biosensing Techniques",
+ "Humans",
+ "Drug Discovery",
+ "Neoplasms",
+ "Antineoplastic Agents",
+ "Fluorescence",
+ "Fluorescence Resonance Energy Transfer",
+ "Signal Transduction",
+ "Luminescent Measurements",
+ "Pentacyclic Triterpenes"
+ ]
+ },
+ {
+ "PMID": "39727719",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia.",
+ "Abstract": "Chemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment continuity, and overall survival. The use of growth factors, including granulocyte colony-stimulating factors (GCSFs), erythropoietin-stimulating agents (ESAs), and thrombopoietin receptor agonists (TPO-RAs), has emerged as a promising strategy for managing CIC. However, the use of these growth factors must be approached with caution. This review provides an overview of the mechanisms, efficacy, and safety of growth factors in the management of CIC. Additionally, we discuss predictive markers for treatment response, potential risks, and highlight areas for future research.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neutropenia",
+ "Antineoplastic Agents",
+ "Anemia",
+ "Thrombocytopenia",
+ "Neoplasms",
+ "Intercellular Signaling Peptides and Proteins",
+ "Granulocyte Colony-Stimulating Factor",
+ "Receptors, Thrombopoietin",
+ "Cytopenia"
+ ]
+ },
+ {
+ "PMID": "39727703",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Assessing Barriers to Cancer Screening and Early Detection in Older Adults in Saudi Arabia: A Mixed-Methods Approach to Oncology Nursing Practice Implications.",
+ "Abstract": "The study underscores the multifaceted barriers faced by older adults in accessing cancer screening in Saudi Arabia. Tailored interventions that address logistical, psychological, and social factors are essential to enhance screening uptake and ensure equitable access to preventive services. These findings contribute to the ongoing discussions on public health strategies and underscore the necessity for community and healthcare provider engagement to improve cancer screening rates in this population.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Saudi Arabia",
+ "Early Detection of Cancer",
+ "Female",
+ "Male",
+ "Aged",
+ "Middle Aged",
+ "Neoplasms",
+ "Oncology Nursing",
+ "Health Services Accessibility",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39727701",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer.",
+ "Abstract": "Frailty and myosteatosis are each prognostic of all-cause mortality (ACM) in patients with cancer. However, it is unclear whether myosteatosis adds value to frailty for predicting ACM. We assessed whether myosteatosis improves the predictive ability of frailty for ACM in older adults undergoing chemotherapy. This was a retrospective study of older adults (\u226565 years) initiating chemotherapy between June 2015 and June 2022. Frailty was assessed using a 24-item frailty index (FI). Myosteatosis was evaluated via computed tomography scans at the third lumbar vertebra (L3).. Multivariable Cox regression and Uno's c-statistic determined the predictive performance of the FI and myosteatosis. In total, 115 participants (mean age: 77.1 years) were included. Frailty alone (adjusted hazards ratio (aHR) = 1.68, 95% confidence intervals (CIs) = 1.03-2.72, ",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Male",
+ "Female",
+ "Frailty",
+ "Neoplasms",
+ "Retrospective Studies",
+ "Aged, 80 and over",
+ "Prognosis"
+ ]
+ },
+ {
+ "PMID": "39727700",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Peripheral Neuropathy Instruments for Individuals with Cancer: A COSMIN-Based Systematic Review of Measurement Properties.",
+ "Abstract": "Although the literature on patient-reported outcomes (PROMs) continues to expand, challenges persist in selecting reliable and valid instruments for assessing peripheral neuropathy (PN) in patients with cancer. This systematic review aimed to identify all validated self-report PN scales and critically appraise their measurement properties. This review was conducted using the COSMIN methodology for PROMs and the PRISMA statement. Five databases were searched from inception to August 2024, identifying 46 eligible studies and 16 PROMs. Evidence quality ranged from \"very low\" to \"moderate\", with notable inconsistencies in the content and structural validity phases of most instruments. Instruments such as the Chemotherapy-induced peripheral neuropathy assessment tool and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity demonstrated moderate quality and potential utility in clinical practice, while others, including the Location-based assessment of sensory symptoms in cancer and the Measure of Ovarian Symptoms and Treatment, had insufficient evidence to support their use. Importantly, all PROMs focused on chemotherapy-induced peripheral neuropathy, highlighting a significant gap in instruments addressing other PN causes, such as radiotherapy or tumor-related nerve damage. Further research should prioritize developing and validating instruments for distinct cancer populations, ensuring robust psychometric properties and clinical applicability.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Peripheral Nervous System Diseases",
+ "Neoplasms",
+ "Patient Reported Outcome Measures",
+ "Psychometrics"
+ ]
+ },
+ {
+ "PMID": "39727690",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Features of the Nurse-Patient Relationship: Insights from a Qualitative Review Using Artificial Intelligence Interpretation.",
+ "Abstract": "The GAI-enabled exploration provided valuable insights into several dimensions of care, emphasizing the importance of spiritual sensitivity, empathic communication, and ongoing professional growth. As technology and human care converge, integrating artistry into the nurse-patient relationship could enhance patient experiences, improve outcomes, and enrich the oncology nursing practice.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Artificial Intelligence",
+ "Empathy",
+ "Neoplasms",
+ "Nurse-Patient Relations",
+ "Oncology Nursing",
+ "Qualitative Research"
+ ]
+ },
+ {
+ "PMID": "39727688",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Symptom Burden and Dietary Changes Among Older Adults with Cancer: A Cross-Sectional Study.",
+ "Abstract": "Taken together, older cancer inpatients are frail and have a high risk of malnutrition. Screening should not only consider energy intake but also symptom burden and dietary changes to optimize supportive care.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Neoplasms",
+ "Cross-Sectional Studies",
+ "Male",
+ "Female",
+ "Malnutrition",
+ "Aged, 80 and over",
+ "Nutritional Status",
+ "Surveys and Questionnaires",
+ "Nutrition Assessment",
+ "Diet",
+ "Symptom Burden"
+ ]
+ },
+ {
+ "PMID": "39727686",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Potential Benefits from Physical Exercise in Advanced Cancer Patients Undergoing Systemic Therapy? A Narrative Review of the Randomized Clinical Trials.",
+ "Abstract": "We reviewed the data of 35 RCTs on the use of physical exercise in cancer patients, distinguishing well-nourished from malnourished patients. The conclusions of our study are the following: No major difference between well-nourished and malnourished patients as regards compliance/adherence with physical exercise and outcomes. Compliance with physical exercise was reported in about 70% of the studies. Compared with a control group receiving the usual care, in patients who practiced physical exercise, a benefit in some parameters of physical function and quality of life and lean body mass (LBM) was reported in 61%, 47%, and 12%, respectively, of the studies in non-malnourished patients, and in 50%, 100%, and 36%, respectively, of the studies in malnourished patients. The benefit in LBM was more frequently reported in weight-losing patients. There was no strict association among the results of different outcomes (muscle function vs. quality of life vs. LBM). There are still some ill-defined issues, including the optimal physical regimen (with some authors favoring high-intensity interval training and resistance) and the place of exercising (patients usually preferring home exercises, which, however, have been proved less efficacious).",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Exercise",
+ "Exercise Therapy",
+ "Neoplasms",
+ "Quality of Life",
+ "Randomized Controlled Trials as Topic"
+ ]
+ },
+ {
+ "PMID": "39727684",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Methadone in Cancer-Related Neuropathic Pain: A Narrative Review.",
+ "Abstract": {
+ "b": "Conclusions",
+ "i": "cancer-related opioid treatment"
+ },
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Methadone",
+ "Neuralgia",
+ "Cancer Pain",
+ "Analgesics, Opioid",
+ "Neoplasms",
+ "Quality of Life"
+ ]
+ },
+ {
+ "PMID": "39727683",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Fertility-Related Concerns in Long-Term Survivors of Childhood Cancer: A Canadian Cohort Study.",
+ "Abstract": "Survivors of childhood cancer face reduced fertility, which can be a significant cause for concern. Our study aimed to assess the prevalence of fertility-related concerns and identify associated factors. Self-report data were collected with the Long-Term Survivor Questionnaire at the Alberta Children's Hospital's Long-Term Survivor Clinic (LTSC) between January 2021 and September 2023. Eligible participants were diagnosed before the age of 21 years, \u22652 years off therapy, and \u226513 years old. We analyzed fertility-related concerns cross-sectionally for the whole sample and longitudinally for a subsample of participants that completed three questionnaires. We included ",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Cancer Survivors",
+ "Male",
+ "Adult",
+ "Adolescent",
+ "Neoplasms",
+ "Young Adult",
+ "Fertility",
+ "Cohort Studies",
+ "Surveys and Questionnaires",
+ "Canada",
+ "Cross-Sectional Studies"
+ ]
+ },
+ {
+ "PMID": "39727682",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Fear of Cancer Recurrence and Fear of Cancer Progression, Digital Resource Engagement and Health Literacy: A Review.",
+ "Abstract": "Cancer care is evolving, and digital resources are being introduced to support cancer patients throughout the cancer journey. Logistical concerns, such as health literacy and the emotional experience of cancer, need to be considered. Fear of cancer recurrence (FCR) and fear of cancer progression (FOP) are relevant emotional constructs that should be investigated. This scoping review explored two main objectives: first, the link between FCR/FOP and engagement with digital resources, and second, the link between FCR/FOP and health literacy. A database search was conducted separately for each objective. Relevant papers were identified, data were extracted, and a quality assessment was conducted. Objective 1 identified two relevant papers that suggested that higher levels of FCR were correlated with lower levels of engagement with digital resources. Objective 2 identified eight relevant papers that indicated that higher FCR/FOP is correlated with lower health literacy. However, one paper with a greater sample size and a more representative sample reported no significant relationship. There may be important relationships between the constructs of FCR/FOP, resource engagement, and health literacy and relationships may differ across cancer type and sex. However, research is limited. No studies examined the relationship between FOP and engagement or FCR/FOP and digital health literacy, and the number of studies identified was too limited to come to a firm conclusion. Further research is needed to understand the significance and relevance of these relationships.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Health Literacy",
+ "Fear",
+ "Neoplasms",
+ "Neoplasm Recurrence, Local",
+ "Disease Progression"
+ ]
+ },
+ {
+ "PMID": "39727182",
+ "Title": "Expert opinion on therapeutic patents",
+ "ArticleTitle": "Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003-present).",
+ "Abstract": "ATM kinase is a promising target for cancer therapy. Small-molecule ATM kinase inhibitors hold significant potential in cancer treatment by enhancing the efficacy of existing DNA-damaging therapies. Patent analysis revealed that the majority of these compounds contain imidazo[4,5-c]quinolinone scaffold or its bioisosteric variations which are optimal in terms of good ATM inhibitory activity and selectivity over closely related enzymes. Clinical trials explore combinations with RT or DNA-targeted compounds like PARP inhibitors, which induce DSBs. The medicinal chemistry field anticipates that these therapeutic options will soon be available on the pharmaceutical market.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Patents as Topic",
+ "Ataxia Telangiectasia Mutated Proteins",
+ "Neoplasms",
+ "Antineoplastic Agents",
+ "Animals",
+ "Protein Kinase Inhibitors",
+ "Drug Development",
+ "Molecular Targeted Therapy",
+ "DNA Breaks, Double-Stranded"
+ ]
+ },
+ {
+ "PMID": "39726750",
+ "Title": "PeerJ",
+ "ArticleTitle": "Malignant solid tumor-related spontaneous intracerebral hemorrhage: a propensity score matching study.",
+ "Abstract": "Decreased HGB levels, elevated LYCs, and a higher NLR were identified as independent risk factors for sICH in patients with active solid malignancies. These markers could assist clinicians in stratifying high-risk patients, facilitating closer monitoring and informing targeted preventive strategies to mitigate the incidence of sICH in this at-risk population.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cerebral Hemorrhage",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Propensity Score",
+ "Risk Factors",
+ "Neoplasms",
+ "Aged",
+ "Prognosis",
+ "Neutrophils",
+ "Hemoglobins",
+ "China",
+ "ROC Curve"
+ ]
+ },
+ {
+ "PMID": "39726590",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "The potential of cellular homing behavior in tumor immunotherapy: from basic discoveries to clinical applications of immune, mesenchymal stem, and cancer cell homing.",
+ "Abstract": "The efficacy of immunotherapy, a pivotal approach in the arsenal of cancer treatment strategies, is contingent on the capacity of effector cells to localize at the tumor site. The navigational capacity of these cells is intricately linked to the homing behaviors of specific cell types. Recent studies have focused on leveraging immune cells and mesenchymal stem cells (MSCs) homing for targeted tumor therapy and incorporating cancer cell homing properties into anti-tumor strategies. However, research and development of immunotherapy based on cancer cell homing remain in their preliminary stages. Enhancing the homing efficiency of effector cells is essential; therefore, understanding the underlying mechanisms and addressing immune resistance within the tumor microenvironment and challenges associated with ",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Cell Movement",
+ "Immunotherapy",
+ "Mesenchymal Stem Cell Transplantation",
+ "Mesenchymal Stem Cells",
+ "Neoplasms",
+ "Tumor Microenvironment"
+ ]
+ },
+ {
+ "PMID": "39726589",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Bibliometric analysis and visualization of the research on the relationship between RNA methylation and immune cell infiltration in tumors.",
+ "Abstract": "Future investigative efforts at the juncture of RNA methylation and tumor immune cells are anticipated to concentrate on domains including m5C, n7-methylguanosine, cuproptosis, prognosis assessment, immunotherapeutic strategies, and the tumor microenvironment.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Bibliometrics",
+ "Methylation",
+ "Tumor Microenvironment",
+ "RNA",
+ "Lymphocytes, Tumor-Infiltrating",
+ "Animals",
+ "RNA Methylation"
+ ]
+ },
+ {
+ "PMID": "39726379",
+ "Title": "Journal of medicinal chemistry",
+ "ArticleTitle": "A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment.",
+ "Abstract": "Lipid metabolism disorder is the cause of one of the most significant metabolic changes in tumors. In the process of tumor occurrence and development, tumor cells choose a continuous metabolic adaptation to accommodate the changing environment to the maximum extent possible. In a variety of tumors, the uptake, production, and storage of lipids are generally upregulated. Tumor cells take advantage of lipid metabolism to access basic energy, biofilm components, and signal molecules of the tumor microenvironment required for proliferation, survival, invasion, and metastasis. This Perspective briefly uncovers the main metabolic processes and key factors involved in lipid metabolism reprogramming, mainly related to lipid uptake, ",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Tumor Microenvironment",
+ "Antineoplastic Agents",
+ "Lipid Metabolism",
+ "Neoplasms",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39726369",
+ "Title": "Nanomedicine (London, England)",
+ "ArticleTitle": "Nanozyme-mediated glutathione depletion for enhanced ROS-based cancer therapies: a comprehensive review.",
+ "Abstract": "Nanozymes can improve reactive oxygen species (ROS)-based cancer therapies by targeting cancer cells' antioxidant defense mechanisms, particularly glutathione (GSH) depletion, to overcome ROS-resistant cancer cells. Nanozymes, innovative enzyme-mimetic nanomaterials, can generate ROS, alter the tumor microenvironment (TME), and synergize with photodynamic therapy (PDT), chemodynamic therapy (CDT), radiotherapy, and immunotherapy. This review shows how nanozymes catalyze ROS generation, selectively deplete GSH, and target cancer elimination, offering clear advantages over standard therapies. Nanozymes selectively target cancer cells' antioxidant defenses to improve PDT, CDT, and radiation therapies. To maximize nanozyme-based cancer treatment efficacy, biodistribution, biocompatibility, and tumor heterogeneity must be assessed. To improve cancer treatment, multifunctional, stimuli-responsive nanozymes and synergistic combination drugs should be developed.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Reactive Oxygen Species",
+ "Glutathione",
+ "Photochemotherapy",
+ "Animals",
+ "Tumor Microenvironment",
+ "Nanostructures",
+ "Antineoplastic Agents",
+ "Photosensitizing Agents",
+ "Antioxidants",
+ "Immunotherapy"
+ ]
+ },
+ {
+ "PMID": "39726308",
+ "Title": "Discovery medicine",
+ "ArticleTitle": "Uncommon but Significant: Onset, Characteristics and Management of Vasculitis and Connective Tissue Diseases Induced by Immunomodulators during Cancer Treatment.",
+ "Abstract": "The introduction of immunomodulators as adjuvant therapies in cancer treatment has represented a significant advancement in oncology, improving therapeutic response and patient survival. Emerging targets and molecules could provide new therapeutic opportunities for cancer patients. However, these agents can induce immunological side effects, including vasculitis and connective tissue diseases, which, while uncommon, present significant clinical challenges. This review analyzes the prevalence, clinical characteristics, therapeutic strategies, and management difficulties of vasculitis and connective tissue disorders triggered by immunomodulators in the context of cancer treatment. Although rare, these conditions significantly impact patients, demanding thorough management. Common rheumatological immune-related adverse events include inflammatory arthritis, Sjogren's disease, systemic lupus erythematosus, and systemic sclerosis, all of which require prompt recognition and appropriate intervention. Treatment frequently includes corticosteroids and immunosuppressive drugs, with new alternatives currently accessible. Efficient coordination between oncologists and rheumatologists enhances patient outcomes, highlighting the necessity for organized multidisciplinary strategies. Future research initiatives emphasize the identification of biomarkers for early diagnosis and the development of preventive methods to reduce immune-related adverse events in cancer therapy.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Connective Tissue Diseases",
+ "Vasculitis",
+ "Immunologic Factors",
+ "Immunomodulating Agents"
+ ]
+ },
+ {
+ "PMID": "39726258",
+ "Title": "Journal of medical virology",
+ "ArticleTitle": "Modified Vaccinia Virus Ankara Selectively Targets Human Cancer Cells With Low Expression of the Zinc-Finger Antiviral Protein.",
+ "Abstract": "Oncolytic viruses are emerging as promising cancer therapeutic agents, with several poxviruses, including vaccinia virus (VACV) and myxoma virus, showing significant potential in preclinical and clinical trials. Modified vaccinia virus Ankara (MVA), a laboratory-derived VACV strain approved by the FDA for mpox and smallpox vaccination, has been shown to be incapable of replicating in human cells unless zinc finger antiviral protein (ZAP) is repressed. Notably, ZAP deficiency is prevalent in various cancer types. We hypothesized that MVA could selectively target and replicate in ZAP-deficient cancer cells. Our study examined MVA's replication across multiple cancer cell lines with varying ZAP expression levels, revealing that MVA replicates more efficiently in cells with lower ZAP expression. Additionally, we assessed MVA's oncolytic potential using a xenograft mouse model, where cancer cells were transplanted into immunodeficient mice. The data demonstrated that MVA significantly reduced tumors with lower ZAP expression without causing morbidity in nude mice. These findings suggest that MVA holds promise for further development as a targeted therapy for ZAP-deficient cancers.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Vaccinia virus",
+ "Humans",
+ "Animals",
+ "Cell Line, Tumor",
+ "Mice",
+ "Mice, Nude",
+ "Virus Replication",
+ "Oncolytic Viruses",
+ "Oncolytic Virotherapy",
+ "RNA-Binding Proteins",
+ "Neoplasms",
+ "Xenograft Model Antitumor Assays",
+ "Female"
+ ]
+ },
+ {
+ "PMID": "39726235",
+ "Title": "Clinical and translational science",
+ "ArticleTitle": "Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors.",
+ "Abstract": "Iruplinalkib (WX-0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first-line therapy for ALK-positive non-small-cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK-positive NSCLC that has progressed following crizotinib therapy. Pharmacokinetics (PK) data of iruplinalkib have been collected in healthy subjects and patient populations in several studies. We developed a population PK (PopPK) model for describing iruplinalkib plasma concentrations and for evaluating whether dose adjustments are necessary based on demographic factors or disease characteristics. Plasma concentration-time data were collected from 392 participants (16 healthy volunteers and 372 patients with solid tumors) who received single or multiple doses of iruplinalkib in four trials. Data were analyzed using non-linear mixed-effects modeling. Iruplinalkib plasma concentrations were best described by a two-compartment model with first-order absorption and first-order elimination. Baseline body weight, time-varying albumin, time-varying creatinine clearance, and time-varying lactate dehydrogenase were significant covariates of apparent clearance from the central compartment (CL/F) while baseline body weight was a significant covariate of apparent volume of the central compartment (V1/F). Given the small or modest effect of all statistically significant covariates on iruplinalkib exposure at steady-state, no covariate was expected to have clinically meaningful effects on iruplinalkib exposure. Furthermore, iruplinalkib absorption was delayed 0.472\u2009h after meal, and K",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Neoplasms",
+ "Aged",
+ "Healthy Volunteers",
+ "Protein Kinase Inhibitors",
+ "Young Adult",
+ "Models, Biological",
+ "Aged, 80 and over",
+ "Carcinoma, Non-Small-Cell Lung"
+ ]
+ },
+ {
+ "PMID": "39726139",
+ "Title": "JMIR cancer",
+ "ArticleTitle": "Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study.",
+ "Abstract": "The analysis of objective pre- and postdiagnostic step count data provided fundamental information crucial for understanding changes in PA among patients with cancer. While cancer diagnosis and treatment reduced PA, the decline may have already started before diagnosis. The study findings may help tailor exercise recommendations based on lifelog data for patients with cancer in the future.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Retrospective Studies",
+ "Female",
+ "Male",
+ "Japan",
+ "Middle Aged",
+ "Exercise",
+ "Smartphone",
+ "Databases, Factual",
+ "Aged",
+ "Adult",
+ "Cohort Studies",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39726004",
+ "Title": "BMC health services research",
+ "ArticleTitle": "Barriers to quality cancer care: a qualitative exploration of oncology case managers' experiences in facilitating guideline implementation in Taiwan.",
+ "Abstract": "Guidelines are vital tools to ensure the quality of cancer care. However, based on the experiences of OCMs, shortcomings in institutional design, hierarchical organizational culture, misconceptions about the role of OCMs, and a lack of support from management have been identified as key obstacles in the implementation process. Suggestions of ways to address these challenges and promote successful guideline implementation are proposed.",
+ "Predictions": [
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Taiwan",
+ "Qualitative Research",
+ "Guideline Adherence",
+ "Practice Guidelines as Topic",
+ "Neoplasms",
+ "Quality of Health Care",
+ "Case Managers",
+ "Medical Oncology",
+ "Interviews as Topic",
+ "Male"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/cardiovascular_diseases.json b/model/dataset/cardiovascular_diseases.json
new file mode 100644
index 0000000000000000000000000000000000000000..32ee416840bc1f3b700a18fd41313dfa49298ab8
--- /dev/null
+++ b/model/dataset/cardiovascular_diseases.json
@@ -0,0 +1,2367 @@
+[
+ {
+ "PMID": "39738181",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Web application using machine learning to predict cardiovascular disease and hypertension in mine workers.",
+ "Abstract": "This study presents a web application for predicting cardiovascular disease (CVD) and hypertension (HTN) among mine workers using machine learning (ML) techniques. The dataset, collected from 699 participants at the Gol-Gohar mine in Iran between 2016 and 2020, includes demographic, occupational, lifestyle, and medical information. After preprocessing and feature engineering, the Random Forest algorithm was identified as the best-performing model, achieving 99% accuracy for HTN prediction and 97% for CVD, outperforming other algorithms such as Logistic Regression and Support Vector Machines. These high accuracies are crucial for occupational health management, where early detection of health risks can significantly reduce morbidity and mortality among workers exposed to environmental and occupational hazards. The web application provides personalized risk assessments based on key factors, such as age, employment history, family health background, and exposure to environmental risks like dust and noise. By offering actionable insights, the model enables targeted interventions, including workplace modifications and lifestyle recommendations, to mitigate the risk of CVD and HTN. This tool demonstrates the potential of ML to enhance preventive health strategies in high-risk occupational settings.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Hypertension",
+ "Machine Learning",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Female",
+ "Iran",
+ "Risk Assessment",
+ "Internet",
+ "Occupational Health",
+ "Miners",
+ "Mining",
+ "Risk Factors",
+ "Occupational Diseases"
+ ]
+ },
+ {
+ "PMID": "39738021",
+ "Title": "Nature communications",
+ "ArticleTitle": "Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.",
+ "Abstract": "Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China. An integrated exposure-response model was used to estimate the association between OP and EPFRs and hospitalization during SDS. EPFRs were strongly associated with circulatory (3.05%; 95% confidence interval [CI]: 1.01%, 4.08%) and respiratory (2.02%; 95% CI: 1.01%, 4.08%) diseases with each increase of 10",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Dust",
+ "Humans",
+ "Hospitalization",
+ "Free Radicals",
+ "Air Pollutants",
+ "Oxidative Stress",
+ "Particulate Matter",
+ "China",
+ "Environmental Exposure",
+ "Beijing",
+ "Sand",
+ "Respiratory Tract Diseases",
+ "Oxidation-Reduction",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39738016",
+ "Title": "Nature communications",
+ "ArticleTitle": "Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.",
+ "Abstract": "The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology. Fecal microbiota transplantation from pair-/alcohol-fed mice into na\u00efve male mice demonstrates the transmissibility of PAGln production and the CVD phenotype. Independent of alcohol exposure, pharmacological-mediated increases in PAGln elicits direct cardiac and vascular dysfunction. PAGln induced hypercontractility and altered calcium cycling in isolated cardiomyocytes providing evidence of improper relaxation which corresponds to elevated filling pressures observed in vivo. Furthermore, PAGln directly induces vascular endothelial cell activation through induction of oxidative stress leading to endothelial cell dysfunction. We thus reveal that the alcohol-induced microbial reorganization and resultant GMM elevation, specifically PAGln, directly contributes to CVD.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Gastrointestinal Microbiome",
+ "Male",
+ "Glutamine",
+ "Cardiovascular Diseases",
+ "Mice",
+ "Humans",
+ "Mice, Inbred C57BL",
+ "Myocytes, Cardiac",
+ "Ethanol",
+ "Oxidative Stress",
+ "Fecal Microbiota Transplantation",
+ "Alcoholism",
+ "Disease Models, Animal",
+ "Female",
+ "Glutamates",
+ "Endothelial Cells",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39736858",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018.",
+ "Abstract": "Adherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "Adult",
+ "Oxidative Stress",
+ "United States",
+ "Aged",
+ "Life Style",
+ "Diet",
+ "Risk Factors",
+ "Follow-Up Studies",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39736721",
+ "Title": "BMC medicine",
+ "ArticleTitle": "Changes in sarcopenia and incident cardiovascular disease in prospective cohorts.",
+ "Abstract": "Changes in sarcopenia status are associated with varying risks of new-onset CVD. Progression in sarcopenia status increases the risk, while recovery from sarcopenia reduces the risk of developing cardiovascular disease.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sarcopenia",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Prospective Studies",
+ "Cardiovascular Diseases",
+ "Incidence",
+ "Aged",
+ "China",
+ "Longitudinal Studies",
+ "Risk Factors",
+ "Proportional Hazards Models"
+ ]
+ },
+ {
+ "PMID": "39736689",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
+ "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
+ "Predictions": [
+ "Diabetes",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Neoplasms",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Longitudinal Studies",
+ "Aged",
+ "Proportional Hazards Models",
+ "Diabetes Mellitus",
+ "Risk Factors",
+ "Cardiometabolic Risk Factors",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39736563",
+ "Title": "BMC cardiovascular disorders",
+ "ArticleTitle": "The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study.",
+ "Abstract": "The hs-CRP/HDL-C ratio is a crucial predictor of long-term mortality in the general population, independent of potential confounding factors.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Cholesterol, HDL",
+ "Retrospective Studies",
+ "C-Reactive Protein",
+ "Biomarkers",
+ "Cardiovascular Diseases",
+ "Risk Assessment",
+ "Adult",
+ "Predictive Value of Tests",
+ "Time Factors",
+ "Nutrition Surveys",
+ "Cause of Death",
+ "Prognosis",
+ "United States",
+ "Risk Factors",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39736401",
+ "Title": "Journal of affective disorders",
+ "ArticleTitle": "Psychosocial and cognitive determinants of 10-year depressive symptom trajectories in patients with cardiovascular disease: The SMART-Medea Study.",
+ "Abstract": "Our findings emphasize that a wide range of psychosocial factors are associated with mild as well as severe trajectories of depressive symptoms in patients with manifest CVD. Focusing on psychosocial factors could improve one's prognosis of depressive symptomology.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Aged",
+ "Depression",
+ "Longitudinal Studies",
+ "Social Support",
+ "Cognition",
+ "Risk Factors",
+ "Anxiety"
+ ]
+ },
+ {
+ "PMID": "39736180",
+ "Title": "Food chemistry",
+ "ArticleTitle": "Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases.",
+ "Abstract": "Dietary omega-3 polyunsaturated fatty acids (D\u03c9-3 PUFAs) have been extensively studied and have been proven to offer notable benefits for heart health. Scientific meta-analysis strongly endorses them as potent bioactive agents capable of preventing and managing cardiovascular diseases (CVDs). Fortification of foods with D\u03c9-3 PUFAs is a potential strategy for enhancing D\u03c9-3 PUFA intake in an effort to continue strengthening public health outcomes. This review analyzed recent trends in the fortification of foods with D\u03c9-3 PUFAs in relation to technological developments, challenges linked to the method, and future scope. Additionally, recent clinical trials and research on the effect of D\u03c9-3 PUFA-fortified food consumption on cardiovascular health are reviewed. Technological trends in fortification methods, namely microencapsulation- and nanoencapsulation, have made considerable progress to date, along with excellent stability in both processing and storage conditions and favorable bioaccessibility and sensory attributes of fortified foods. There is a tremendous deal of promise for cardiovascular health based on recent clinical trial findings that fortifying food with D\u03c9-3 PUFAs decreased the incidence of heart disease, blood pressure, and lipid profiles. In summary, substantial progress has been made in addressing the challenges of D\u03c9-3 PUFA fortification. However, further multidisciplinary research is needed to inculcate effectiveness toward achieving the maximum possible D\u03c9-3 PUFAs to protect against the harmful effects of CVDs and continue global health progress.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Food, Fortified",
+ "Fatty Acids, Omega-3",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39736025",
+ "Title": "Polish journal of veterinary sciences",
+ "ArticleTitle": "Cardiovascular problems in rabbits in reference to hypothyroidism - a four-year retrospective study.",
+ "Abstract": "The effects of T4 are mainly manifested by positive ino- and chronotropism. The syndrome accompanying hypothyroidism in rabbits (impaired myocardial contractility and reduced ejection capacity) is caused by a deficiency of thyroid hormones - especially T4. The study group consisted of a total of 41 animals: 15 males and 26 females, ranging in age from 2 months to 8 years, with echocardiogram showing reduced fractional shortening (<30%), with normal results of heamatological and biochemical tests. Blood was collected in order to measure T4 level. Echocardiographic examinations were performed with two-dimensional (2D) imaging, M-mode measurements and the pulsed/colour-labelled Doppler technique. Statistical analysis was performed using Statistica 13.0. Correlations were determined: between serum thyroxine concentration and the value of the fraction of shortening in the groups: young animals (up to 5 years of age) and older animals, females and males, and sterilised and non-sterilised animals. Statistical analysis showed a positive correlation between T4 levels in the blood of the test animals and myocardial fractional shortening and heart rate and left-atrial to aortic ratio (LA/Ao) in the pre-treatment period. A positive correlation was also shown after dividing the patients into 2 groups based on their age (below 5 years vs. 5 years and over), sex (male and female rabbits) and fact of sterilization (yes/no). Our study unequivocally confirmed a positive correlation between the decreased serum T4 concentration and reduced fractional shortening, indicating decreased cardiac systolic function in hypothyroid rabbits.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Rabbits",
+ "Male",
+ "Hypothyroidism",
+ "Female",
+ "Retrospective Studies",
+ "Thyroxine",
+ "Cardiovascular Diseases",
+ "Echocardiography"
+ ]
+ },
+ {
+ "PMID": "39735642",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease.",
+ "Abstract": "Our research found that longer LTL improved survival in patients with ALD and decreased CVD and cancer-related mortality. LTL decreased all-cause mortality especially for patients older than 65 years or men. LTL might be a useful biomarker for prognosis among patients with ALD. More prospective studies are needed to assess the relevance between LTL and mortality and explore the underlying mechanisms between them.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Leukocytes",
+ "Liver Diseases, Alcoholic",
+ "Telomere",
+ "Adult",
+ "Nutrition Surveys",
+ "Prognosis",
+ "Telomere Homeostasis",
+ "Aged",
+ "Risk Factors",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39735545",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Single chain fragment variable, a new theranostic approach for cardiovascular diseases.",
+ "Abstract": "Cardiovascular diseases (CVDs) remain a significant global health challenge, leading to substantial morbidity and mortality. Despite recent advancements in CVD management, pharmaceutical treatments often suffer from poor pharmacokinetics and high toxicity. With the rapid progress of modern molecular biology and immunology, however, single-chain fragment variable (scFv) molecule engineering has emerged as a promising theranostic tool to offer specificity and versatility in targeting CVD-related antigens. To represent the latest development on the potential of scFv in the context of CVDs, this review summarized the new mechanism of action and applications as therapeutic, as well as diagnostic agents. Furthermore, the advantages of scFv, including its small size, ease of modification, and ability to be engineered for enhanced affinity and specificity, are also described. Finally, such challenges as immunogenicity, stability, and scalability, alongside strategies to overcome these hurdles, are deeply scrutinized to provide safer and more effective strategies for the diagnosis and treatment of the incurable CVDs.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Single-Chain Antibodies",
+ "Animals",
+ "Theranostic Nanomedicine",
+ "Precision Medicine"
+ ]
+ },
+ {
+ "PMID": "39735488",
+ "Title": "Turkish journal of medical sciences",
+ "ArticleTitle": "Thyroid and cardiovascular diseases.",
+ "Abstract": "The thyroid gland is one of the major regulator organs of hemostasis in the human body, controlling the functioning of numerous systems. Thyroid hormones exert a modulating effect on the cardiovascular system in particular, ensuring optimal functioning within the normal range. Triiodothyronine (T3), as an active form of thyroid hormone, is mainly responsible for this effect via both genomic and nongenomic mechanisms. It has been reported that overt thyroid disorders are associated with a number of cardiovascular diseases and cardiac mortality. While hyperthyroidism appears to be related to atrial fibrillation and heart failure, the most pronounced cardiovascular complication of hypothyroidism seems to be atherosclerosis. Achieving euthyroidism is of great importance for restoring cardiovascular function. However, depending on the underlying health conditions, this may not be possible for all patients. Furthermore, there has been a growing focus on the role of subclinical thyroid dysfunctions and their impacts on the cardiovascular system in recent years. The pattern of cardiovascular abnormalities in subclinical thyroid disorders appears to parallel that of overt hypothyroidism, suggesting that even mild alterations in thyroid hormone levels may also have effects on the cardiovascular system. The management of subclinical thyroid disease remains controversial. Current evidence suggests that patient age and underlying cardiovascular diseases are major factors in clinical decision-making.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Hypothyroidism",
+ "Hyperthyroidism",
+ "Thyroid Diseases",
+ "Thyroid Gland",
+ "Thyroid Hormones"
+ ]
+ },
+ {
+ "PMID": "39735485",
+ "Title": "Turkish journal of medical sciences",
+ "ArticleTitle": "Cardiac effects and comorbidities of neurological diseases.",
+ "Abstract": "Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, and peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These disorders profoundly impact cardiovascular health, prompting an intensified exploration into the intricate interconnections between the neurological and cardiovascular systems. This review synthesizes current insights and research on cardiovascular comorbidities associated with major neurological conditions, including stroke, epilepsy, Parkinson's disease, multiple sclerosis, and Alzheimer's disease. The cardiovascular sequelae of these neurological disorders are multifactorial. For instance, strokes not only predispose individuals to arrhythmia and heart failure but also exacerbate preexisting cardiovascular risk factors. Similarly, epilepsy is associated with autonomic dysregulation and an elevated risk of sudden cardiac death, underscoring the necessity for vigilant cardiac monitoring in affected individuals. Parkinson's disease manifests with orthostatic hypotension and cardiac sympathetic denervation, significantly contributing to morbidity. Additionally, multiple sclerosis and Alzheimer's disease exhibit cardiovascular autonomic dysfunction and heightened cardiovascular risk, underscoring the need for proactive management strategies. Mechanistically, these conditions disrupt autonomic nervous system regulation, induce chronic inflammation, and may share genetic susceptibilities, each contributing to cardiovascular pathology. Effective management of these complexities requires an integrative approach that includes risk factor modification, pharmacotherapy, lifestyle interventions, and comprehensive patient education. Future research directions include identifying novel therapeutic targets, conducting large-scale clinical trials, and investigating genetic biomarkers to individualize treatment strategies. By addressing the multifaceted interactions between neurological disorders and cardiovascular health, healthcare providers can optimize patient care, reducing cardiovascular morbidity and mortality in this vulnerable population.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Comorbidity",
+ "Nervous System Diseases",
+ "Cardiovascular Diseases",
+ "Parkinson Disease",
+ "Risk Factors",
+ "Multiple Sclerosis"
+ ]
+ },
+ {
+ "PMID": "39733208",
+ "Title": "Scientific reports",
+ "ArticleTitle": "XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study.",
+ "Abstract": "Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent CVD. A cross-sectional study was conducted with school-aged children and adolescents in Ouro Preto, Minas Gerais. The study evaluated cardiovascular risk factors' variables and XbaI polymorphism in the APOB gene for associations with increased total cholesterol (TC). The prevalence of increased TC was notably high, reaching 68.9% in the study population. Carriers of the variant T allele were 1.45 times more likely to develop increased TC in a dominant model (1.09-1.94, p\u2009=\u20090.011). After adjustments, excess weight and a family history of dyslipidemia interacted significantly with XbaI polymorphism in increased TC, resulting in Odds Ratio of 1.74 (1.11-2.71, p\u2009=\u20090.015) and 2.04 (1.14-3.67, p\u2009=\u20090.016), respectively. The results suggest that XbaI polymorphism in the APOB gene may affect the lipid profile of Brazilian children and adolescents and could contribute to the CVD in adulthood.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Child",
+ "Female",
+ "Male",
+ "Cross-Sectional Studies",
+ "Apolipoproteins B",
+ "Cholesterol",
+ "Brazil",
+ "Genetic Predisposition to Disease",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Dyslipidemias",
+ "Apolipoprotein B-100",
+ "Polymorphism, Genetic",
+ "Alleles",
+ "Polymorphism, Single Nucleotide"
+ ]
+ },
+ {
+ "PMID": "39733181",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Assessment of meteorological factors and air pollution impact on cardiovascular mortality using random forest analysis 2017 to 2020.",
+ "Abstract": "Air pollution, a global health hazard, significantly impacts mortality, cardiovascular health, mental well-being, and overall human health. This study aimed to investigate the impact of air pollution and meteorological factors on cardiovascular mortality rates in Mashhad City, northeastern Iran in 2017-2020. We utilized a Random Forest (RF) model in this study. We gathered daily meteorological data (pressure, humidity, temperature, solar radiation) from 2017 to 2020, pollutant levels (PM",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Air Pollution",
+ "Air Pollutants",
+ "Iran",
+ "Meteorological Concepts",
+ "Particulate Matter",
+ "Seasons",
+ "Sulfur Dioxide",
+ "Climate Change",
+ "Weather",
+ "Random Forest"
+ ]
+ },
+ {
+ "PMID": "39733164",
+ "Title": "Scientific reports",
+ "ArticleTitle": "New-onset cardiovascular diseases post SARS-CoV-2 infection in an urban population in the Bronx.",
+ "Abstract": "This study investigated the incidence of new-onset cardiovascular disorders up to 3.5 years post SARS-CoV-2 infection for 56,400 individuals with COVID-19 and 1,093,904 contemporary controls without COVID-19 in the Montefiore Health System (03/11/2020 to 07/01/2023). Outcomes were new incidence of major adverse cardiovascular event (MACE), arrhythmias, inflammatory heart disease, thrombosis, cerebrovascular disorders, ischemic heart disease and other cardiac disorders between 30 days and (up to) 3.5 years post index date. Results were also compared with a pre-pandemic cohort over similar observation duration (N\u2009=\u200964,541). Cumulative incidence and hazard ratios adjusted for competitive risks were analyzed. Compared to contemporary controls, hospitalized COVID-19 patients had significantly higher risk of developing MACE (aHR\u2009=\u20092.29, 95% confidence interval [2.27, 2.31], p\u2009<\u20090.001), arrhythmias (aHR\u2009=\u20092.54[2.50, 2.58], p\u2009<\u20090.001), inflammatory heart disease (aHR\u2009=\u20095.34[4.79, 5.96], p\u2009<\u20090.001), cerebrovascular (aHR\u2009=\u20092.05[2.00, 2.11], p\u2009<\u20090.001), other cardiac disorders (aHR\u2009=\u20092.31[2.26, 2.35], p\u2009<\u20090.001), thrombosis (aHR\u2009=\u20094.25[4.15, 4.36], p\u2009<\u20090.001), and ischemic heart disease (aHR\u2009=\u20091.89[1.86, 1.92], p\u2009<\u20090.001). Non-hospitalized COVID-19 patients had slightly higher risk of developing MACE (aHR\u2009=\u20091.04[1.03, 1.06], p\u2009<\u20090.001), arrhythmias (aHR\u2009=\u20091.10[1.08, 1.12], p\u2009<\u20090.001), inflammatory heart disease (aHR\u2009=\u20092.29 [2.03, 2.59], p\u2009<\u20090.001), cerebrovascular (aHR\u2009=\u20091.11[1.07, 1.15], p\u2009<\u20090.001), and ischemic heart disease (aHR\u2009=\u20091.10[1.08, 1.13], p\u2009<\u20090.001). Race and ethnicity were mostly not associated with increased risks (p\u2009>\u20090.05). aHRs with contemporary controls as a reference were similar to those with pre-pandemic cohort as a reference. We concluded that new incident cardiovascular disorders in COVID-19 patients, especially those hospitalized for COVID-19, were higher than those in controls. Identifying risk factors for developing new-onset cardiovascular disorders may draw clinical attention for the need for careful follow-up in at-risk individuals.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Incidence",
+ "SARS-CoV-2",
+ "Urban Population",
+ "Adult",
+ "New York City",
+ "Risk Factors",
+ "Hospitalization",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39733154",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association of the triglyceride-glucose index with cardiovascular mortality risk and competing risks in arthritis patients.",
+ "Abstract": "This study aims to investigate the relationship between the triglyceride-glucose index (TyG) and all-cause mortality as well as cardiovascular mortality in arthritis patients. Additionally, it seeks to analyze the nonlinear characteristics and threshold effects of TyG index. We included 5,559 adult participants with arthritis from the 1999-2018 National Health and Nutrition Examination Survey (NHANES). The TyG index was calculated using fasting triglycerides and glucose levels. We employed Cox proportional hazards models and restricted cubic spline analyses to examine the relationship between TyG index and all-cause mortality in arthritis patients. Competing risks models were used to analyze the association between TyG index and cardiovascular mortality as well as mortality from other causes. Over a median follow-up period of 7.8 years, 1,388 cases of all-cause mortality were recorded among arthritis patients, including 369 cases of cardiovascular mortality. After adjusting for confounding factors, TyG index was found to be nonlinearly positively associated with all-cause mortality (P\u2009=\u20090.0019), with a significant increase in mortality risk when TyG index\u2009\u2265\u20098.43. Compared to the quartile 2 of TyG index, the highest quartile was associated with a 36% increased risk of all-cause mortality (HR 1.36, 95% CI 1.12-1.65). Additionally, competing risks models indicated that high TyG index levels were significantly associated with increased risks of cardiovascular mortality and mortality from other causes. Subgroup analyses confirmed the robustness of the association between TyG index and cardiovascular mortality in arthritis patients. The TyG index is nonlinearly associated with all-cause mortality and represents a potential prognostic indicator for mortality risk in arthritis patients.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Triglycerides",
+ "Arthritis",
+ "Blood Glucose",
+ "Nutrition Surveys",
+ "Risk Factors",
+ "Adult",
+ "Aged",
+ "Proportional Hazards Models"
+ ]
+ },
+ {
+ "PMID": "39733150",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Availability, price and affordability of essential medicines for managing cardiovascular disease in Addis Ababa, Ethiopia.",
+ "Abstract": "Access to health care is a fundamental human right. However, nearly one-third of the global population have no access to it. This magnitude is even much worse in low- and middle-income countries. A cross-sectional study was conducted from April 12 to June 5, 2024 to determine availability, price and affordability of essential medicines for managing cardiovascular diseases using WHO/HAI methodology in Addis Ababa, Ethiopia. Data on the availability and price of the lowest priced generic medicines were collected from five public, ten private and eight other sectors in Addis Ababa, Ethiopia. The availability was assessed as the percentage of health facilities that stocked the listed medicines. The prices of these medicines were evaluated across all sectors. Price variations were calculated to identify differences among these settings. Additionally, medicine prices were compared against the management sciences for health (MSH) International Reference Prices to calculate the Median Price Ratio (MPR), providing a standardized measure of price affordability and accessibility. The data was analyzed using WHO/HAI work book Excel sheet V 15. The overall availability of generic drugs in all sectors was found to be 34.52%. The availability was 33.73, 40.58, 29.8 and 33.99% in Public, Private, Kenema and Red Cross pharmacies, respectively. The median price ratios for the medications used to treat cardiovascular disease were 3.49, 7.24, 2.84 and 5.2 at Public, Private, Kenema, and Red Cross Pharmacies, respectively. Majority of the medicines were found to be unaffordable, costing up to 352.44\u00a0days' wage of the lowest paid government employee to cover a one-month standard treatment. In conclusion, the study underscores significant challenges in the availability, pricing, and affordability of LPG medications to treat CVDs in Ethiopia.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Ethiopia",
+ "Humans",
+ "Cardiovascular Diseases",
+ "Drugs, Essential",
+ "Cross-Sectional Studies",
+ "Health Services Accessibility",
+ "Drugs, Generic",
+ "Drug Costs"
+ ]
+ },
+ {
+ "PMID": "39733137",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association between blood manganese and cardiovascular diseases among U.S. adult population.",
+ "Abstract": "Manganese (Mn) is a known toxicant and an essential trace element, and it plays an important role in various mechanisms in relation to cardiovascular health. However, epidemiological studies of the association between blood Mn and cardiovascular diseases (CVD) among U.S. adults are rare. A cross-sectional study of 12,061 participants aged\u2009\u2265\u200920 was conducted using data from the National Health and Nutrition Examination Survey 2011-2018. Logistic regression and restricted cubic spline were used to examine the relationship between blood Mn levels and total CVD risk and specific CVD subtypes. Bayesian kernel-machine regression (BKMR) and weighted quantile sum (WQS) analyses were performed to explore the joint effects of Mn with other metals on CVD. The results showed that individuals with the third quartile group of blood Mn levels had significantly lower risks of CVD, displaying a non-linear U-shaped dose-response relationship. A significant interaction of age on this association was observed. No significant associations were found between Mn levels and specific CVD subtypes. BKMR and WQS analyses showed a positive association between heavy metal mixtures and CVD risks, with no interaction between Mn and other metals. In conclusion, blood Mn levels were significantly associated with CVD risks with a U-shaped relationship in U.S. adults, with possible age-specific differences. Future larger prospective studies are warranted to validate these findings.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Manganese",
+ "Cardiovascular Diseases",
+ "Adult",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "United States",
+ "Cross-Sectional Studies",
+ "Nutrition Surveys",
+ "Aged",
+ "Young Adult",
+ "Risk Factors",
+ "Bayes Theorem"
+ ]
+ },
+ {
+ "PMID": "39732966",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Assessment of dyslipidemia management in Turkey using a Delphi panel.",
+ "Abstract": "This study evaluated the management of dyslipidemia in Turkey with the goal of understanding current diagnosis and treatment patterns, as well as identifying unmet needs in achieving effective low-density lipoprotein cholesterol (LDL-C) targets. Using a Delphi panel consisting of nine expert cardiologists, the study reveals key gaps in dyslipidemia management, particularly in the underutilization of combination therapies, such as statins and PCSK9 inhibitors, which are crucial for achieving LDL-C targets in high-risk patients. The findings indicate that while many patients with very high cardiovascular risk are diagnosed, a significant proportion do not receive optimal treatment to reach LDL-C levels recommended by European guidelines. Addressing these gaps could lead to more effective management of dyslipidemia and reduce the burden of cardiovascular disease in Turkey. The study's insights provide critical recommendations for clinicians and policymakers to improve clinical practice and health outcomes through more aggressive lipid-lowering strategies.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Dyslipidemias",
+ "Humans",
+ "Turkey",
+ "Delphi Technique",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Cholesterol, LDL",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "PCSK9 Inhibitors"
+ ]
+ },
+ {
+ "PMID": "39732729",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.",
+ "Abstract": "Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and plays a pivotal role in the pathogenesis of vascular diseases such as atherosclerosis, hypertension, and vascular inflammation. In cardiometabolic diseases, PVAT becomes a significant source of proflammatory adipokines, leading to increased infiltration of immune cells, in cardiometabolic diseases, PVAT becomes a significant source of proinflammatory adipokines, leading to increased infiltration of immune cells, promoting vascular smooth muscle cell proliferation and migrationpromoting vascular smooth muscle cell proliferation and migration. This exacerbates vascular dysfunction by impairing endothelial cell function and promoting endothelial activation. Dysregulated PVAT also contributes to hemodynamic alterations and hypertension through enhanced sympathetic nervous system activity and impaired vasodilatory capacity of PVAT-derived factors. Therapeutic interventions targeting key components of this interaction, such as modulating PVAT inflammation, restoring adipokine balance, and attenuating immune cell activation, hold promise for mitigating obesity-related vascular complications. Lifestyle interventions, pharmacological agents targeting inflammatory pathways, and surgical approaches aimed at reducing PVAT mass or improving adipose tissue function are potential therapeutic avenues for managing vascular diseases associated with obesity and PVAT dysfunction.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Adipokines",
+ "Adipose Tissue",
+ "Adiposity",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus",
+ "Inflammation Mediators",
+ "Obesity",
+ "Signal Transduction"
+ ]
+ },
+ {
+ "PMID": "39732498",
+ "Title": "BMJ open",
+ "ArticleTitle": "Investigating context-specific sedentary behaviours and cardiometabolic health in college-based young adults (CONTEXT-SB): a protocol for a longitudinal observational study.",
+ "Abstract": "This study has received full ethical approval, and participants provide written informed consent. Our hypothesis is that certain CS-SB will show stronger associations with CMD risk, compared with total sedentary behaviour (T-SB), even after accounting for coexisting lifestyle behaviours. We also expect a range of intra-individual, inter-individual and physical environmental socioecological factors will predict CS-SB. Findings addressing both the primary and any secondary research aims will be submitted for publication in a high-impact peer-reviewed journal.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sedentary Behavior",
+ "Young Adult",
+ "Longitudinal Studies",
+ "Male",
+ "Adolescent",
+ "Female",
+ "Cardiovascular Diseases",
+ "Universities",
+ "Cardiometabolic Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39732415",
+ "Title": "Clinica chimica acta; international journal of clinical chemistry",
+ "ArticleTitle": "High-sensitivity cardiac troponin T and N-terminal b-type natriuretic propeptide are associated with cardiac and all-cause mortality in older adults - A population-based ten-year follow-up study.",
+ "Abstract": "Our study shows that older population with higher cTnT and proBNP concentrations have an increased risk of cardiovascular and all-cause mortality. Acknowledging the elevated risk may aid in targeting follow-up, prevention, and treatment adequately and more individually.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Troponin T",
+ "Aged",
+ "Male",
+ "Female",
+ "Follow-Up Studies",
+ "Natriuretic Peptide, Brain",
+ "Cardiovascular Diseases",
+ "Aged, 80 and over",
+ "Biomarkers",
+ "Peptide Fragments"
+ ]
+ },
+ {
+ "PMID": "39732216",
+ "Title": "International journal of pharmaceutics",
+ "ArticleTitle": "Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals.",
+ "Abstract": "Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Antioxidants",
+ "Flavonoids",
+ "Nanoparticles",
+ "Animals",
+ "Neuroprotective Agents",
+ "Cosmeceuticals",
+ "Neoplasms",
+ "Biological Availability",
+ "Nanoparticle Drug Delivery System",
+ "Antineoplastic Agents",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39731858",
+ "Title": "Maturitas",
+ "ArticleTitle": "Wearable devices, ischemic heart disease and cardiovascular outcomes: A systematic review and meta-analysis.",
+ "Abstract": "CRD42024586137.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Myocardial Ischemia",
+ "Wearable Electronic Devices",
+ "Randomized Controlled Trials as Topic",
+ "Myocardial Infarction",
+ "Hospitalization",
+ "Cardiovascular Diseases",
+ "Stroke"
+ ]
+ },
+ {
+ "PMID": "39731821",
+ "Title": "Biosensors & bioelectronics",
+ "ArticleTitle": "All-in-one microfluidic immunosensing device for rapid and end-to-end determination of salivary biomarkers of cardiovascular diseases.",
+ "Abstract": "Routine screening for cardiovascular diseases (CVDs) through point-of-care assays for at-home or community-based testing of salivary biomarkers can significantly improve patient outcomes. However, its translatability has been hindered by a dearth of biosensing devices that streamline assay procedures for rapid biomarker quantitation. To address this challenge through end-to-end engineering, we developed an in-house, all-in-one microfluidic immunosensing device that integrates on-chip vibration-enhanced incubation, magnetic-assisted separation using immune magnetic bead probes, and colorimetric readout via absorbance measurements. This device enables probe preparation and one-pot immunoassay procedures on a reusable microfluidic chip. By engaging the vibrator with the reaction chamber, the vibration-enhanced incubation module significantly accelerates immune complex formation, drastically reducing the sample-to-answer timeline of approximately 1\u00a0h required for room temperature enzyme-linked immunosorbent assay (ELISA) to just under 15\u00a0min. We showcase the utility of the device with an on-demand assay for a biomarker panel comprising C-reactive protein (CRP), interleukin 6 (IL-6), and procalcitonin (PCT). The device achieved a linear detection range of 1.75-28\u00a0ng\u00a0mL",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biosensing Techniques",
+ "Biomarkers",
+ "Cardiovascular Diseases",
+ "Saliva",
+ "Lab-On-A-Chip Devices",
+ "Immunoassay",
+ "Interleukin-6",
+ "C-Reactive Protein",
+ "Equipment Design",
+ "Procalcitonin",
+ "Limit of Detection"
+ ]
+ },
+ {
+ "PMID": "39731110",
+ "Title": "Nutrition journal",
+ "ArticleTitle": "Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults.",
+ "Abstract": "Our results suggest that IAA, IPA, IAld, and IPA-predicting microbial score are favorably associated with several cardiometabolic risk markers, although IAld may decrease HDL-C levels.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Bacteria",
+ "Biomarkers",
+ "Blood Glucose",
+ "Cardiometabolic Risk Factors",
+ "Cardiovascular Diseases",
+ "China",
+ "Cholesterol, HDL",
+ "Cholesterol, LDL",
+ "Cohort Studies",
+ "East Asian People",
+ "Feces",
+ "Gastrointestinal Microbiome",
+ "Indoleacetic Acids",
+ "Indoles",
+ "Propionates",
+ "Triglycerides"
+ ]
+ },
+ {
+ "PMID": "39731068",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.",
+ "Abstract": "Among the general American population, baseline CMI levels exhibited an L-shaped nonlinear relationship with all-cause mortality, and the threshold value was 0.98. What's more, CMI may become an effective indicator for CVD, cancer, and all-cause mortality prediction. Further investigation is essential to confirm our findings.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "Neoplasms",
+ "Adult",
+ "Aged",
+ "Triglycerides",
+ "Cause of Death",
+ "Waist Circumference",
+ "Cholesterol, HDL",
+ "Proportional Hazards Models",
+ "Kaplan-Meier Estimate",
+ "Body Mass Index",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39731058",
+ "Title": "BMC psychiatry",
+ "ArticleTitle": "The relationship between life's essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults.",
+ "Abstract": "This study indicates a significant negative correlation between overall cardiovascular health measured by LE8 scores and depression. Prioritizing interventions targeting lifestyle modifications to alleviate the burden of depression in public health initiatives is crucial.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "United States",
+ "Middle Aged",
+ "Depression",
+ "Adult",
+ "Nutrition Surveys",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Severity of Illness Index"
+ ]
+ },
+ {
+ "PMID": "39730958",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Combined effect of triglyceride-glucose index and atherogenic index of plasma on cardiovascular disease: a national cohort study.",
+ "Abstract": "The triglyceride-glucose (TyG) index and the Atherogenic Index of Plasma (AIP) are both predictors of cardiovascular diseases (CVD). However, their combined and individual contributions to CVD risk are not well understood. This study evaluate the joint and individual associations of the TyG index and AIP with CVD events in middle-aged and older Chinese adults. This nationwide, retrospective cohort study utilized data from CHARLS. The diagnosis of CVD in this study was determined based on self-reported information provided by participants regarding their medical history( heart disease and/or stroke). Cross-sectional analyses in 2011 and longitudinal analyses over a 9-year follow-up were conducted to assess these associations. In the cross-sectional analysis, 8,531 participants were included at baseline. The odds ratio (OR) for TyG alone was 1.06 (95% CI 0.96-1.22) for CVD, while the OR for AIP alone was 1.16 (95% CI 1.02-1.33). Combined analysis showed that compared to the low TyG & low AIP group, the OR for the high TyG & high AIP group was 1.23 (95% CI 1.07-1.42) for CVD. In the survival Analysis, the hazard ratio (HR) for TyG alone was 1.19 (95% CI 1.04-1.35) for CVD, while the HR for AIP alone was 1.25 (95% CI 1.09-1.43). Combined analysis showed that compared to the low TyG & low AIP group, the HR for the high TyG & high AIP group was 1.27 (95% CI 1.10-1.43) for CVD. The findings underscore the significant coexposure effects of the TyG index and AIP on CVD, particularly in middle-aged adults.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Triglycerides",
+ "Female",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Blood Glucose",
+ "Aged",
+ "Retrospective Studies",
+ "Cross-Sectional Studies",
+ "Atherosclerosis",
+ "China",
+ "Risk Factors",
+ "Longitudinal Studies",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39730871",
+ "Title": "Communications biology",
+ "ArticleTitle": "Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.",
+ "Abstract": "Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, their underlying pathological mechanisms are still unclear. Leveraging GWAS summary data and using genetic correlation, pleiotropic variants identification, and colocalization analyses, we identified 11 colocalized loci for CVDs-CeVDs-BP (blood pressure), CVDs-CeVDs-LIP (lipid traits), and CVDs-CeVDs-cIMT (carotid intima-media thickness) triplets. No shared causal loci were found for CVDs-CeVDs-T2D (type 2 diabetes) or CVDs-CeVDs-BMI (body mass index) triplets. The 11 loci were mapped to 12 genes, namely CASZ1, CDKN1A, TWIST1, CDKN2B, ABO, SWAP70, SH2B3, LRCH1, FES, GOSR2, RPRML, and LDLR, where both GOSR2 and RPRML were mapped to one locus. They were enriched in pathways related to cellular response to external stimulus and regulation of the phosphate metabolic process and were highly expressed in endothelial cells, epithelial cells, and smooth muscle cells. Multi-omics analysis revealed methylation of two genes (CASZ1 and LRCH1) may play a causal role in the genetic pleiotropy. Notably, these pleiotropic loci are highly enriched in the targets of antihypertensive drugs, which further emphasizes the role of the blood pressure regulation pathway in the shared etiology of CVDs and CeVDs.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cerebrovascular Disorders",
+ "Cardiovascular Diseases",
+ "Cardiometabolic Risk Factors",
+ "Genome-Wide Association Study",
+ "Genetic Predisposition to Disease",
+ "Polymorphism, Single Nucleotide",
+ "Carotid Intima-Media Thickness",
+ "Genetic Pleiotropy"
+ ]
+ },
+ {
+ "PMID": "39730843",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Smoking-associated electrocardiographic abnormalities predict cardiovascular mortality.",
+ "Abstract": "Background -Smoking is associated with arrhythmia and sudden cardiac death, but the biological mechanisms remain unclear. In electrocardiogram (ECG) recordings abnormal durations of ventricular repolarization (QT interval), atrial depolarization (P wave), and atrioventricular depolarization (PR interval and segment), predict cardiac arrhythmia and mortality. Previous analyses of the National Health and Nutrition Examination Survey (NHANES) database for associations between smoking and ECG abnormalities were incomplete. To elucidate how smoking affects cardiac excitation, we assessed in a nationally representative sample (NHANES III) the association between serum cotinine and P duration, PR interval, PR segment, rate-corrected QT (QTc), QRS duration, and JT interval. Methods and Results-We analyzed data from 5,653 adults using survey-weighted multinomial logistic regression to estimate associations between tobacco use (>\u200915 ng/ml serum cotinine) and short (<\u20095th percentile) or long (>\u200995th percentile) ECG intervals, relative to reference (5-95th percentile). After adjustment for demographics, risk factors, and conduction-altering medications, smoking was associated with a higher odds of short PR interval, PR segment, and QRS, and long JT. Broader effects of smoking on ECG were also assessed by survey-weighted linear regression of continuous cotinine and ECG, which revealed cotinine inversely associated with PR segment and QTc. Over a 22-year follow-up, many ECG abnormalities predicted cardiovascular mortality in smokers, including long JT, QRS, and QTc, and short QRS, whereas only short JT predicted mortality in nonsmokers. Conclusions -Smoking increases likelihood for rapid atrioventricular and ventricular depolarization and slow ventricular repolarization, which may promote cardiac arrhythmia and mortality.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Electrocardiography",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Smoking",
+ "Adult",
+ "Cotinine",
+ "Arrhythmias, Cardiac",
+ "Nutrition Surveys",
+ "Risk Factors",
+ "Aged",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39730815",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Combined association of physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults.",
+ "Abstract": "Cardiometabolic risk factors such as obesity, raised blood pressure, high blood glucose and dyslipidemia are emerging health concerns worldwide. Therefore, the aim of this study was to estimate the combined association between physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults. Data was obtained from the National Health Survey of Chile 2016-2017, with a sample of 5995 adult participants. Assessment of Physical activity and depressive symptoms were done using the Global Physical Activity Questionnaire (GPAQ) and the CIDI ShortForm (CIDI-SF), respectively. Multivariable logistic regression was performed to estimate the combined association of physical activity and depressive symptoms with cardiometabolic risk factors. Participants in the category\u2009\u2265\u2009150\u00a0min/Depressive symptoms had the highest prevalence of overweight (OR: 1.55, 95% CI: 1.17-2.05), obesity (OR: 1.97, 95% CI: 1.49-2.59) and high waist circumference (OR: 1.63, 95% CI: 1.39-1.92). Participants in the <\u2009150\u00a0min/No depressive symptoms category had a lower prevalence of overweight/obesity (OR: 0.68, 95% CI: 0.60-0.78) and a 25% reduced high triglycerides prevalence, in comparison with the active category with no depressive symptoms. There is a positive association between depressive symptoms and overweight, obesity and waist circumference among subjects that complete physical activity recommendations but have depressive symptoms.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chile",
+ "Male",
+ "Female",
+ "Exercise",
+ "Adult",
+ "Middle Aged",
+ "Depression",
+ "Cardiometabolic Risk Factors",
+ "Obesity",
+ "Prevalence",
+ "Overweight",
+ "Risk Factors",
+ "Aged",
+ "Young Adult",
+ "Cardiovascular Diseases",
+ "Waist Circumference",
+ "Cross-Sectional Studies"
+ ]
+ },
+ {
+ "PMID": "39730723",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study.",
+ "Abstract": "Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases. However, current evidence on the association between CMI and kidney stone risk is limited. The primary objective of this study was to investigate the association between CMI and kidney stones in US adults and to analyze whether diabetes mediates the association. Using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and March 2018, this study examined the association between CMI and kidney stones incidence in US adults. Data were analyzed using a variety of statistical methods, including multifactorial logistic regression, subgroup analysis, restricted cubic spline curves (RCS), saturated threshold effects analysis, and mediated effects analysis. A total of 10,609 subjects were included in this study, of which 972 patients were diagnosed with kidney stones. The results of multifactorial logistic regression analysis after fully adjusting for confounding covariates showed a significant positive association between CMI and kidney stones, with an odds ratio (OR) of 1.29 and a 95% confidence interval (CI) of (1.16,1.44). In addition, there was a non-linear positive association between CMI and kidney stones. The results of mediation analysis showed that diabetes mellitus had a mediating role of 15.3% in the correlation between CMI and kidney stones. The findings of this study indicate that elevated CMI levels are associated with an increased risk of kidney stone formation, with diabetes playing a mediating role. These findings indicate that maintaining CMI within the lower range and addressing glycemic regulation is crucial for the prevention of kidney stones.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Kidney Calculi",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Adult",
+ "Diabetes Mellitus",
+ "Nutrition Surveys",
+ "Risk Factors",
+ "Aged",
+ "Cardiovascular Diseases",
+ "United States",
+ "Incidence",
+ "Logistic Models"
+ ]
+ },
+ {
+ "PMID": "39730493",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Heart rate variability parameters indicate altered autonomic tone in subjects with COVID-19.",
+ "Abstract": "COVID-19 is associated with long-term cardiovascular complications. Heart Rate Variability (HRV), a measure of sympathetic (SNS) and parasympathetic (PNS) control, has been shown to predict COVID-19 outcomes and correlate with disease progression but a comprehensive analysis that includes demographic influences has been lacking. The objective of this study was to determine the balance between SNS, PNS and heart rhythm regulation in hospitalized COVID-19 patients and compare it with similar measurements in healthy volunteers and individuals with cardiovascular diseases (CVD), while also investigating the effects of age, Body Mass Index (BMI), gender and race. Lead I ECG recordings were acquired from 50 COVID-19 patients, 31 healthy volunteers, and 51 individuals with cardiovascular diseases (CVD) without COVID-19. Fourteen HRV parameters were calculated, including time-domain, frequency-domain, nonlinear, and regularity metrics. The study population included a balanced demographic profile, with 55% of participants being under 65 years of age, 54% identifying as male, and 68% identifying as White. Among the COVID-19 patients, 52% had a BMI\u2009\u2265\u200930 compared to 29% of healthy volunteers and 33% of CVD patients. COVID-19 and CVD patients exhibited significantly reduced time-domain HRV parameters, including SDNN and RMSSD, compared to healthy volunteers (SDNN: 0.02\u2009\u00b1\u20090.02\u00a0s vs. 0.06\u2009\u00b1\u20090.03\u00a0s, p\u2009<\u20090.001; RMSSD: 0.02\u2009\u00b1\u20090.02\u00a0s vs. 0.05\u2009\u00b1\u20090.03\u00a0s, p\u2009=\u20090.08). In the frequency domain, both COVID-19 and CVD patients showed increased low-frequency (LF) power and lower high-frequency (HF) power compared to healthy volunteers (COVID-19 LF: 18.47\u2009\u00b1\u200918.18%, HF: 13.69\u2009\u00b1\u200925.80%; Healthy LF: 23.30\u2009\u00b1\u200911.79%, HF: 22.91\u2009\u00b1\u200921.86%, p\u2009<\u20090.01). The LF/HF ratio was similar in COVID-19 patients (1.038\u2009\u00b1\u20091.54) and healthy volunteers (1.03\u2009\u00b1\u20090.78). Nonlinear parameters such as SD1 were significantly lower in COVID-19 patients (0.04\u2009\u00b1\u20090.04\u00a0s vs. 0.08\u2009\u00b1\u20090.05\u00a0s, p\u2009<\u20090.01), indicating altered autonomic regulation. Variations in HRV were observed based on demographic factors, with younger patients, females, and non-white individuals showing more pronounced autonomic dysfunction. COVID-19 patients exhibit significant alterations in HRV, indicating autonomic dysfunction, characterized by decreased vagal tone and sympathetic dominance, similar to patients with severe cardiovascular comorbidities. Despite higher heart rates, the HRV analysis suggests COVID-19 is associated with substantial disruption in autonomic regulation, particularly in patients with specific demographic risk factors.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Male",
+ "Heart Rate",
+ "Female",
+ "Middle Aged",
+ "Autonomic Nervous System",
+ "Aged",
+ "Adult",
+ "Cardiovascular Diseases",
+ "Electrocardiography",
+ "SARS-CoV-2",
+ "Body Mass Index"
+ ]
+ },
+ {
+ "PMID": "39730152",
+ "Title": "BMJ open",
+ "ArticleTitle": "Association of diet quality and nutrient intake with odds of dyslipidaemia in patients with cardiovascular diseases: a hospital based cross-sectional study in Bangladesh.",
+ "Abstract": "A high-quality diet was associated with significantly lower odds of dyslipidaemia, hypercholesterolaemia, hypertriglyceridaemia and elevated LDL cholesterol. The study findings highlight the potential of targeted nutritional interventions with a multifaceted approach to managing dyslipidaemia, emphasising the need for personalised dietary guidelines that consider the individual's gender, occupation and BMI.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Bangladesh",
+ "Cross-Sectional Studies",
+ "Dyslipidemias",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Adult",
+ "Diet",
+ "Aged, 80 and over",
+ "Logistic Models",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39729514",
+ "Title": "PloS one",
+ "ArticleTitle": "Global burden of cardiovascular disease mortality attributable to secondhand smoke, 1990-2019: Systematic analysis of the Global Burden of Disease Study 2019.",
+ "Abstract": "Over the past three decades, the epidemiological landscape of CVD mortality associated with secondhand smoke has undergone significant shifts. Notwithstanding global advancements, intensified interventions are paramount in regions experiencing ascending rates.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Tobacco Smoke Pollution",
+ "Global Burden of Disease",
+ "Male",
+ "Female",
+ "Disability-Adjusted Life Years",
+ "Middle Aged",
+ "Global Health",
+ "Adult",
+ "Aged",
+ "Quality-Adjusted Life Years"
+ ]
+ },
+ {
+ "PMID": "39729492",
+ "Title": "PloS one",
+ "ArticleTitle": "Association between exposure to urinary metal and all-cause and cardiovascular mortality in US adults.",
+ "Abstract": "Combining all models, it is possible that Sb may have a more stable impact on all-cause and cardiovascular mortality. Meaningful metal effects in individual statistical models still require careful attention.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Adult",
+ "United States",
+ "Nutrition Surveys",
+ "Bayes Theorem",
+ "Environmental Exposure",
+ "Metals",
+ "Aged",
+ "Proportional Hazards Models",
+ "Cause of Death",
+ "Lead"
+ ]
+ },
+ {
+ "PMID": "39729424",
+ "Title": "PloS one",
+ "ArticleTitle": "Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT study.",
+ "Abstract": "Disease networks offer a potential road map of connections between diseases. Several studies have created disease networks where diseases are connected either based on shared genes or Single Nucleotide Polymorphism (SNP) associations. However, it is still unclear to which degree SNP-based networks map to empirical, co-observed diseases within a different, general, adult study population spanning over a long time period. We created a SNP-based phenome-wide association network (PheNet) from a large population using the UK biobank phenome-wide association studies. Importantly, the SNP-associations are unbiased towards much studied diseases, adjusted for linkage disequilibrium, case/control imbalances, as well as relatedness. We map the PheNet to significantly co-occurring diseases in the Norwegian HUNT study population, and further, identify consecutively occurring diseases with significant ordering in occurrence, independent of age and gender in the PheNet. Our analysis reveals an overlap far larger than expected by chance between the two disease networks, with diseases typically connecting within their own category. Upon examining the sequential occurrence of diseases in the HUNT dataset, we find a giant component consisting of mostly cardiovascular disorders. This allows us to identify sequentially occurring diseases that are genetically linked and co-occur frequently, while also highlighting non-sequential diseases. Furthermore, we observe that survivors of severe cardiovascular diseases subsequently often face less severe conditions, but with a reduced time until their next fatal illness. The HUNT sub-PheNet showing both genetically and co-observed diseases offers an interesting framework to study groups of diseases and examine if they, in fact, are comorbidities. We find that the HUNT sub-PheNet offers the possibility to pinpoint exactly which mutation(s) constitute shared cause of the diseases. This could be of great benefit to both researchers and clinicians studying relationships between diseases.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Polymorphism, Single Nucleotide",
+ "Genome-Wide Association Study",
+ "Male",
+ "Female",
+ "Phenotype",
+ "Norway",
+ "Genetic Predisposition to Disease",
+ "Cardiovascular Diseases",
+ "Phenomics",
+ "Middle Aged",
+ "Linkage Disequilibrium",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39727377",
+ "Title": "Iranian journal of kidney diseases",
+ "ArticleTitle": "Correlation Analysis of Blood Pressure Variability, Crystalloid Osmotic Pressure, and Cardiovascular Events in Maintenance Hemodialysis Patients.",
+ "Abstract": "Elevated crystalloid osmotic pressure, SBP-CV, and DBP-CV are critical risk factors with strong predictive value for predicting CEs in MHD patients.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Blood Pressure",
+ "Renal Dialysis",
+ "Crystalloid Solutions",
+ "Osmotic Pressure",
+ "Aged",
+ "Kidney Failure, Chronic",
+ "Cardiovascular Diseases",
+ "Risk Factors",
+ "Adult",
+ "ROC Curve"
+ ]
+ },
+ {
+ "PMID": "39727210",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Inflammatory Markers and Measures of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.",
+ "Abstract": "URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02936843, NCT02017171.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Autonomic Nervous System",
+ "Autonomic Nervous System Diseases",
+ "Biomarkers",
+ "Cardiovascular Diseases",
+ "Cardiovascular System",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus, Type 1",
+ "Diabetic Neuropathies",
+ "Heart Rate",
+ "Inflammation",
+ "Inflammation Mediators",
+ "Receptors, Urokinase Plasminogen Activator"
+ ]
+ },
+ {
+ "PMID": "39726401",
+ "Title": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
+ "ArticleTitle": "Targeting GSK-3\u03b2 for adipose dysfunction and cardiovascular complications of metabolic disease: An\u00a0entangled WNT/\u03b2-catenin question.",
+ "Abstract": "Individuals with metabolic syndrome have a high risk of developing cardiovascular disorders that is closely tied to visceral adipose tissue dysfunction, as well as an altered interaction between adipose tissue and the cardiovascular system. In metabolic syndrome, adipose tissue dysfunction is associated with increased hypertrophy, reduced vascularization, and hypoxia of adipocytes, leading to a pro-oxidative and pro-inflammatory environment. Among the pathways regulating adipose tissue homeostasis is the wingless-type mammary tumor virus integration site family (Wnt) signaling pathway, with both its canonical and non-canonical arms. Various modulators of the Wnt signaling have been identified to contribute to the development of metabolic diseases and their cardiovascular complications, with a particularly significant role played by Glycogen Synthase Kinase-3\u03b2 (GSK-3\u03b2). GSK-3\u03b2 levels and activities have various and often contrasting roles in obesity and related metabolic disorders, as well as their cardiovascular sequelae. Here, we explore the possibility that altered Wnt signaling and GSK-3\u03b2 activities could serve as a connection between adipose tissue dysfunction and the development of cardiovascular disease in individuals with metabolic syndrome. We attempt to define a context-specific approach for intervention, which could possibly serve as a novel disease modifying therapy for the mitigation of such complications.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glycogen Synthase Kinase 3 beta",
+ "Cardiovascular Diseases",
+ "Wnt Signaling Pathway",
+ "Animals",
+ "Adipose Tissue",
+ "beta Catenin",
+ "Metabolic Syndrome",
+ "Metabolic Diseases"
+ ]
+ },
+ {
+ "PMID": "39725874",
+ "Title": "BMC cardiovascular disorders",
+ "ArticleTitle": "U-shaped association of uric acid to HDL cholesterol ratio (UHR) with ALL-cause and cardiovascular mortality in diabetic patients: NHANES 1999-2018.",
+ "Abstract": "This study found a U-shaped relationship between UHR and both ALL-cause and cardiovascular mortality in diabetic population. This suggests that clinicians should control UHR around 9-10 to improve the long-term prognosis of diabetic patients.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Uric Acid",
+ "Nutrition Surveys",
+ "Cholesterol, HDL",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus",
+ "Biomarkers",
+ "Risk Assessment",
+ "Cause of Death",
+ "United States",
+ "Time Factors",
+ "Adult",
+ "Longitudinal Studies",
+ "Prognosis",
+ "Aged",
+ "Sex Factors",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39725697",
+ "Title": "Translational psychiatry",
+ "ArticleTitle": "Association of \u03b1-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.",
+ "Abstract": "This study examines \u03b1-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007-2016) and mortality details from the National Death Index up to December 31, 2019. Including 3329 participants with depression, findings revealed 485 all-cause and 113 cardiovascular deaths. To investigate the nonlinear association between \u03b1-klotho and mortality, the Cox proportional hazards regression model, restricted cubic splines, and two-piecewise Cox proportional hazards model were developed. Analyzes indicated an \"L-shaped\" relationship between ln-transformed \u03b1-klotho levels and all-cause mortality, with a significant threshold effect at 6.53 ln(pg/ml). Below this threshold, ln-transformed \u03b1-klotho levels were inversely related to all-cause mortality (adjusted HR 0.33, 95%CI\u2009=\u20090.19-0.56), with no significant association above it (adjusted HR 1.41, 95%CI\u2009=\u20090.84-2.36). Cardiovascular mortality showed no link to \u03b1-klotho levels. Subgroup analysis shown that, the association between ln-transformed \u03b1-klotho concentration and all-cause mortality was consistent in subgroups according to gender, age, BMI, race, and depression(adjusted P\u2009>\u20090.05). The study uncovers a non-linear \"L-shaped\" association between ln-transformed \u03b1-klotho levels and all-cause mortality in depressed individuals, suggesting \u03b1-klotho assessment as a tool for identifying high-risk patients and guiding preventive strategies to enhance survival.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Klotho Proteins",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "United States",
+ "Prospective Studies",
+ "Adult",
+ "Nutrition Surveys",
+ "Aged",
+ "Cause of Death",
+ "Depression",
+ "Proportional Hazards Models",
+ "Mortality",
+ "Depressive Disorder"
+ ]
+ },
+ {
+ "PMID": "39725339",
+ "Title": "Pharmacological research",
+ "ArticleTitle": "Wnt/\u03b2-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches.",
+ "Abstract": "Wnt and Notch signaling pathways play crucial roles in the development and homeostasis of the cardiovascular system. These pathways regulate important cellular processes in cardiomyocytes, endothelial cells, and smooth muscle cells, which are the key cell types involved in the structure and function of the heart and vasculature. During embryonic development, Wnt and Notch signaling coordinate cell fate specification, proliferation, differentiation, and morphogenesis of the heart and blood vessels. In the adult cardiovascular system, these pathways continue to maintain tissue homeostasis and arrange adaptive responses to various physiological and pathological stimuli. Dysregulation of Wnt and Notch signaling has been involved in the pathogenesis of numerous cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and heart failure. Abnormal activation or suppression of these pathways in specific cell types can contribute to endothelial dysfunction, vascular remodeling, cardiomyocyte hypertrophy, impaired cardiac contractility and dead. Understanding the complex interplay between Wnt and Notch signaling in the cardiovascular system has led to the investigation of these pathways as potential therapeutic targets in clinical trials. In conclusion, this review summarizes the current knowledge on the roles of Wnt and Notch signaling in the development and homeostasis of cardiomyocytes, endothelial cells, and smooth muscle cells. It further discusses the dysregulation of these pathways in the context of major cardiovascular diseases and the ongoing clinical investigations targeting Wnt and Notch signaling for therapeutic intervention.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "beta Catenin",
+ "Cardiovascular Diseases",
+ "Receptors, Notch",
+ "Wnt Signaling Pathway"
+ ]
+ },
+ {
+ "PMID": "39724625",
+ "Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
+ "ArticleTitle": "STATE OF CARDIOVASCULAR SYSTEM IN SERVICEMEN OF UKRAINE ARMED FORCES AND EMERGENCY WORKERS OF THE CHORNOBYL ACCIDENT. COMPARATIVE ANALYSIS.",
+ "Abstract": "The EW group differed from SM in a more severe course of HHD, CHD and HF, they had more severechanges in the structure of left ventricular myocardium. Most likely, this is explained by the fact that the incidenceof HHD and CHD occurs at a younger age, and therefore by the longer duration of these diseases, which led to moresevere pathological myocardial remodeling.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chernobyl Nuclear Accident",
+ "Male",
+ "Ukraine",
+ "Middle Aged",
+ "Emergency Responders",
+ "Adult",
+ "Military Personnel",
+ "Electrocardiography",
+ "Radiation Exposure",
+ "Occupational Exposure",
+ "Hypertension",
+ "Echocardiography",
+ "Cardiovascular System",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39724617",
+ "Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
+ "ArticleTitle": "LEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).",
+ "Abstract": "The overall mortality of Chornobyl clean-up workers from non-tumor diseases tends to increase. Theresults of the risk analysis of dose dependent mortality in the Chornobyl clean-up workers cohort showed a highersensitivity to ionizing radiation of persons of the younger age group (18-39 years old at the date of the accident).The most dangerous period of relative dose-dependent risk of death of Chornobyl clean-up workers due to non-tumordiseases was established - 6-10 years after radiation exposure for all dose subgroups (from 0.05 Gy to 0.7 Gy) relative to the subgroup with a radiation dose < 0.05 Gy.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chernobyl Nuclear Accident",
+ "Male",
+ "Adult",
+ "Occupational Exposure",
+ "Middle Aged",
+ "Ukraine",
+ "Radiation Exposure",
+ "Radiation Dosage",
+ "Occupational Diseases",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Gamma Rays",
+ "Radiation Injuries",
+ "Risk Assessment",
+ "Cerebrovascular Disorders",
+ "Myocardial Infarction",
+ "Respiratory Tract Diseases",
+ "Digestive System Diseases",
+ "Emergency Responders",
+ "Adolescent",
+ "Cardiomyopathies"
+ ]
+ },
+ {
+ "PMID": "39724119",
+ "Title": "Psychiatria Danubina",
+ "ArticleTitle": "SOMA: SCREENING AND SOMATIC HEALTH INTERVENTION PROGRAM FOR PEOPLE WITH SEVERE MENTAL ILLNESS.",
+ "Abstract": "Progress in psychiatric treatment has led to important improvements in the quality of life of patients with severe mental illness (SMI). Nevertheless, the life expectancy of patients with SMI remains two decades shorter than that of the general population, and the most prevalent cause of death is cardiovascular disease. Given that the delivery of somatic care to a population of individuals with mental illness is specific, we developed a screening and intervention programme aimed at this vulnerable population. The \"SOMA\" programme is a complex somatic health intervention system consisting of screening and a set of interventions. Risk screening is evaluated automatically; the interventions include dietary intervention, healthy lifestyle education (HSE), physiotherapy, kinesiotherapy, and occupational therapy (KOP). The programme was introduced into the practice of the hospital, and its outcomes were monitored with a pilot population divided into 2 subprogrammes. CV risk factor prevalence study (n= 5481) as the most common CV risk factors identified hypertension (56.6 %) and smoking (55.7 %), high-risk patients proportion was 1364 (27 %). HSE (n=40) enrolled patients improved their body weight. KOP results show that patients with schizophrenia preferred physical activity less than others; 53 % of patients have no physical activity during hospitalization, and spontaneous physical activity depends on BMI in our sample. We observed improvement in cognitive functioning, perception of physical functions, or perceived limitations was comparable to the general population. Results show the usability of the program design; initial screening with two intervention branches can increase motivation for physical activity and adoption of health-promoting behaviors and support a recovery process in SMI patients. SOMA project is unique in the Czech environment, however, larger sample with longer observation period is needed.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mental Disorders",
+ "Male",
+ "Adult",
+ "Female",
+ "Middle Aged",
+ "Schizophrenia",
+ "Mass Screening",
+ "Healthy Lifestyle",
+ "Occupational Therapy",
+ "Cardiovascular Diseases",
+ "Pilot Projects",
+ "Risk Factors",
+ "Physical Therapy Modalities"
+ ]
+ },
+ {
+ "PMID": "39723980",
+ "Title": "Circulation",
+ "ArticleTitle": "Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach.",
+ "Abstract": "There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular-liver-metabolic health. Metabolic dysfunction and associated insulin resistance, together with the predilection for ectopic fat deposition in the liver and surrounding tissues, are associated with elevated risk of endothelial dysfunction, systemic inflammatory response, and ectopic fat deposition in the epicardium. This complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic dysfunction, valvular calcification, and cardiac arrhythmias. Despite the mounting evidence of mechanistic pathways underpinning MASLD and CVD, current recommendations have not clearly focused upon MASLD as a risk factor or target for intervention in CVD. We have brought together a diverse range of international experts committed to promoting cardiovascular-liver-metabolic health and related outcomes across the globe. The overarching goal of this document is to offer a construct for clinicians in the cardiovascular field with regards to (1) diagnosis and screening of MASLD through the use of noninvasive serum and imaging tests; (2) screening for CVD in all individuals with MASLD regardless of established atherosclerotic risk factors; and (3) the approach to management of MASLD with respect to prevention of CVD through lifestyle, as well as pharmacologic and surgical strategies. To achieve this, the modified Delphi method was applied and a series of evidence-based quality standard recommendations have been identified.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Delphi Technique",
+ "Fatty Liver",
+ "Mass Screening",
+ "Metabolic Syndrome",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39723782",
+ "Title": "The American journal of nursing",
+ "ArticleTitle": "COVID-19 Infection Shown to Increase the Risk of Adverse Cardiac Events.",
+ "Abstract": "Elevated risk can last for several years after infection.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Risk Factors",
+ "SARS-CoV-2",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39723699",
+ "Title": "Journal of cachexia, sarcopenia and muscle",
+ "ArticleTitle": "Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies.",
+ "Abstract": "These two large cohorts provided reliable evidence that gut microbiota alterations in NWO resemble those found in obesity, yet also display unique aspects. This distinct microbiota profile may contribute to heightened cardiometabolic risks in adults with normal BMI.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Obesity",
+ "Cohort Studies",
+ "Cardiovascular Diseases",
+ "China",
+ "Body Mass Index",
+ "Adult",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39722803",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Negative correlation between cardiometabolic index and testosterone in male adults.",
+ "Abstract": "Elevated CMI is significantly and negatively correlated with testosterone in male adults.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Testosterone",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Middle Aged",
+ "Triglycerides",
+ "Nutrition Surveys",
+ "Insulin Resistance",
+ "Cholesterol, HDL",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Cardiometabolic Risk Factors",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39722158",
+ "Title": "Journal of evidence-based medicine",
+ "ArticleTitle": "Prevalence and Cardio-Renal Comorbidities of Masked Hypertension: A Meta-Analysis.",
+ "Abstract": "Masked hypertension is prevalent in adults and associated with increased risks of all-cause mortality, cardiovascular disease, cardiovascular mortality, and composite renal events.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Comorbidity",
+ "Kidney Diseases",
+ "Masked Hypertension",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39721760",
+ "Title": "Thorax",
+ "ArticleTitle": "Inhaled corticosteroids and major cardiovascular events in people with chronic obstructive pulmonary disease.",
+ "Abstract": "ICS did not reduce MACE, except HF, likely by reducing misclassified COPD exacerbations.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Male",
+ "Female",
+ "Aged",
+ "Administration, Inhalation",
+ "Bronchodilator Agents",
+ "Cardiovascular Diseases",
+ "England",
+ "Adrenal Cortex Hormones",
+ "Middle Aged",
+ "Heart Failure",
+ "Acute Coronary Syndrome"
+ ]
+ },
+ {
+ "PMID": "39721361",
+ "Title": "Sleep medicine",
+ "ArticleTitle": "Chinese consensus report on the assessment and management of obstructive sleep apnea in patients with cardiovascular disease: 2024 edition.",
+ "Abstract": "As cardiovascular disease (CVD) incidence and mortality rates continue to rise in China, the importance of identifying and managing CVD risk factors grows. Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder, affecting an estimated 936 million individuals aged 30-69 worldwide, with China leading globally with about 176 million affected. Increasing research indicates a close association between OSA and the onset and progression of various CVD, significantly affecting outcomes. However, OSA has long been underrecognized and undertreated in CVD clinical practice. To address this gap, a multidisciplinary expert panel developed evidence-based recommendations using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology and the Delphi process. This consensus provides 17 recommendations on core clinical issues such as screening, diagnosis, treatment, and follow-up of CVD patients with OSA, aiming to standardize care and improve patient outcomes. The recommendations were informed by current evidence-based research and extensive expert consensus discussions. This approach seeks to support clinical decision-making, improve the quality of care, and address the unique challenges of managing OSA in Chinese CVD patients.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Sleep Apnea, Obstructive",
+ "Humans",
+ "Cardiovascular Diseases",
+ "China",
+ "Consensus",
+ "Risk Factors",
+ "Delphi Technique",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39720249",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Traditional versus intensive blood glucose control: long-term target range duration and cardiovascular disease risk and all-cause mortality - a real-world cohort study.",
+ "Abstract": "In patients with type 2 diabetes, achieving near-normal blood glucose levels appears to significantly reduce the risk of diabetes-related cardiovascular outcomes.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Middle Aged",
+ "Blood Glucose",
+ "Glycemic Control",
+ "Cohort Studies",
+ "Aged",
+ "Follow-Up Studies",
+ "Risk Factors",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Cause of Death",
+ "China"
+ ]
+ },
+ {
+ "PMID": "39719690",
+ "Title": "Chinese medical journal",
+ "ArticleTitle": "Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications.",
+ "Abstract": "This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer survival rates have improved over the last two decades, the risk of CVD has risen over time in patients with cancer. CVD and cancer share similar risk factors and a common pathophysiology involving inflammation. Many chemotherapeutic agents used to treat cancer are associated with cardiovascular complications (such as heart failure, myocardial infarction, and thrombosis). Current evidence indicates a significant burden of CVD in patients with cancer, particularly in the first year following cancer diagnosis, with elevated risk persisting beyond this period. This short- and long-term risk of CVD may vary depending on the cancer type and treatment regimen. Early identification of potential cardiovascular risk in patients with cancer, can lead to more favorable clinical and survival outcomes. Given the acute and long-term consequences, patients with cancer require increased cardiovascular care and lifestyle optimization. This article offers valuable insights into the cardiovascular burden and needs of patients with cancer. It is intended for a general medical research readership interested in the intersection of cardiology and oncology.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Cardiovascular Diseases",
+ "Prognosis",
+ "Risk Factors",
+ "Antineoplastic Agents"
+ ]
+ },
+ {
+ "PMID": "39719674",
+ "Title": "Nanomedicine (London, England)",
+ "ArticleTitle": "Applications of carbon dot-mediated cardiomyocyte maturation in regenerative medicine: a review.",
+ "Abstract": "The maturation of cardiomyocytes (CMs) plays key roles in regenerative medicine and the treatment of cardiovascular diseases via stem cell-derived CMs. Carbon dots (CDs) have good biocompatibility, optical properties, and electrophysical properties and have been widely applied in bioimaging, biosensors, and biotherapy. In this review, we comprehensively summarize recent advances in promoting the maturation of CMs, mainly human pluripotent stem cell-derived CMs, and related regenerative medicine. Moreover, we explore the innovative application of CDs to enhance the maturation of these CMs. Finally, we look forward to the future design and application of CDs in the maturation of CMs in terms of cell therapies.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Regenerative Medicine",
+ "Myocytes, Cardiac",
+ "Carbon",
+ "Cell Differentiation",
+ "Animals",
+ "Quantum Dots",
+ "Pluripotent Stem Cells",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39719571",
+ "Title": "BMC public health",
+ "ArticleTitle": "Association between the female hormone intake and cardiovascular disease in the women: a study based on NHANES 1999-2020.",
+ "Abstract": "Although many studies have reported the relationship between female hormone intake and cardiovascular disease (CVD) development, their association has not been fully elucidated and defined, based on data from the Third National Health and Nutrition Examination Survey intending to assess the health and nutritional status of non-institutionalized children and adults in the United States. This study examined the relationship between female hormone intake and coronary artery disease (CVD) development in 38,745 women, averaging 38.10\u2009\u00b1\u200912.59\u00a0years in age. We explored the association between hormone intake and CVD incidence, considering various social determinants of health (SDOH) with statistical methods like Chi-square tests, logistic regression, and stratified Chi-square analysis. Our findings reveal a complex relationship between female hormone intake and CVD development. Hormones appear to reduce CVD risk in women over 60\u00a0years old. However, hormone intake correlates with increased CVD risk in highly educated women. Socioeconomic status also influences this relationship; while hormones pose a risk factor for heart failure and stroke in impoverished or wealthy women, they serve as a protective factor against CVD for middle-income women. Additionally, hormonal intake seems beneficial for women who experienced menarche between 13 and 15\u00a0years old, menopause between 30 and 49, and had 7-9 pregnancies, especially when coupled with a diet low in sugar, fat, cholesterol, and adequate folic acid intake. These results indicate that while hormones can prevent CVD under specific conditions, their impact can be detrimental in different SDOH contexts. In conclusion, while appropriate hormone intake can prevent CVD, its effects vary across different demographic and health backgrounds. This underscores the necessity for meticulous screening of SDOH factors in clinical settings to maximize the protective benefits of hormones against CVD.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Nutrition Surveys",
+ "Adult",
+ "United States",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Risk Factors",
+ "Young Adult",
+ "Incidence"
+ ]
+ },
+ {
+ "PMID": "39719456",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association of cardiovascular disease on cancer: observational and mendelian randomization analyses.",
+ "Abstract": "Extensive research is needed to examine the association between cardiovascular disease (CVD) and cancer. The observational study is based on data collected from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). To assess the connection between CVDs and cancer, we used a weighted multivariable logistic regression analysis with as many confounding factors as feasible included in the model. By employing Mendelian randomization (MR), the unbiased causal relationship between CVDs and cancers was ascertained. The primary analytical approach employed the Inverse Variance Weighted methodology. In cross-sectional study, a positive correlation was observed between CVD and cancer (Model 3, Odds ratio 1.26, 95% confidence interval 1.01\u2009~\u20091.57, p\u2009=\u20090.040). However, MR analysis indicated a negative causal relationship between certain subtypes of CVD and specific cancers, with effect sizes for coronary heart disease and lung cancer (\u03b2 = -\u00a04.759, p\u2009=\u20090.002), breast cancer (\u03b2 = -\u00a02.684, p\u2009=\u20090.026), colorectal cancer (\u03b2 = -\u00a04.581, p\u2009=\u20090.042), liver cancers (\u03b2 = -\u00a019.264, p\u2009=\u20090.028), and stroke with prostate cancer (\u03b2 = -\u00a00.299, p\u2009=\u20090.017), with no evidence of a positive correlation. Results from the reverse MR causal analysis revealed a positive correlation between prostate cancer and angina pectoris. An observational study linked CVDs risk to cancer risk. MR analysis has shown that the expected incidence of CVDs can reduce the probability of developing certain forms of cancer. Further investigation is required to examine the clinical correlations and underlying processes between these two illnesses.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Neoplasms",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Risk Factors",
+ "Aged",
+ "Nutrition Surveys",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39719431",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Association Between Sleep Duration and Cardiovascular Disease Among Asian Americans.",
+ "Abstract": "Our study highlights the heterogeneity of CVD prevalence associated with suboptimal sleep duration among Asian American adults. Future studies should consider how different measures of sleep duration and quality affect CVD outcomes among disaggregated Asian American subgroups.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Asian",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "United States",
+ "Prevalence",
+ "Adult",
+ "Aged",
+ "Sleep",
+ "Time Factors",
+ "Risk Factors",
+ "Risk Assessment",
+ "Cross-Sectional Studies",
+ "Health Surveys",
+ "Sleep Duration"
+ ]
+ },
+ {
+ "PMID": "39719421",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease.",
+ "Abstract": "Among patients with CKD stages 3b/4, patients with hyperkalemia experienced significantly higher risks of major adverse cardiovascular events and arrhythmia in hospital settings relative to patients without hyperkalemia.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hyperkalemia",
+ "Male",
+ "Renal Insufficiency, Chronic",
+ "Female",
+ "Aged",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Risk Assessment",
+ "Risk Factors",
+ "Potassium",
+ "Aged, 80 and over",
+ "Arrhythmias, Cardiac",
+ "Retrospective Studies"
+ ]
+ },
+ {
+ "PMID": "39719405",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Cardiovascular Health Status in US Adults With Chronic Diseases: National Health and Nutrition Examination Survey (NHANES), 2013-2018.",
+ "Abstract": "CVH is significantly poorer in adults with many chronic diseases compared with unaffected adults. These data suggest the utility of the LE8 score to identify groups for targeted optimization of CVH to enhance primary and secondary prevention efforts for cardiovascular disease and potentially for concomitant chronic diseases of aging.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Adult",
+ "Nutrition Surveys",
+ "Chronic Disease",
+ "United States",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Health Status",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39719315",
+ "Title": "Acta medica Okayama",
+ "ArticleTitle": "Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk.",
+ "Abstract": "Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Kidney Neoplasms",
+ "Male",
+ "Nephrectomy",
+ "Female",
+ "Middle Aged",
+ "Propensity Score",
+ "Aged",
+ "Retrospective Studies",
+ "Cardiovascular Diseases",
+ "Risk Factors",
+ "Carcinoma, Renal Cell"
+ ]
+ },
+ {
+ "PMID": "39719183",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD.",
+ "Abstract": "NAFLD-non-MASLD patients with 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L are still at high risk of poor clinical outcomes. These findings support including 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L as a component of the metabolic dysfunction definition.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Non-alcoholic Fatty Liver Disease",
+ "Blood Glucose",
+ "Retrospective Studies",
+ "Glucose Tolerance Test",
+ "Adult",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Risk Factors",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39719182",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study.",
+ "Abstract": "YKL-40 is a prognostic biomarker for most CVEs, and even more so for all-cause mortality, primarily driven by cancer-related causes.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Chitinase-3-Like Protein 1",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Denmark",
+ "Cardiovascular Diseases",
+ "Biomarkers",
+ "Cohort Studies",
+ "C-Reactive Protein"
+ ]
+ },
+ {
+ "PMID": "39718412",
+ "Title": "Journal of human nutrition and dietetics : the official journal of the British Dietetic Association",
+ "ArticleTitle": "Tea Consumption and Long-Term Mortality in Very Elderly Individuals With or Without Cardiovascular and Cerebrovascular Disease: Findings From a Sample of 19664 Chinese.",
+ "Abstract": "Among very elderly Chinese individuals, frequent tea consumption was associated with reduced mortality over the short term, particularly in those who maintained this habit throughout life. No significant interaction effect was observed between pre-existing CCD and the mortality benefits of tea consumption.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Tea",
+ "Cerebrovascular Disorders",
+ "Cardiovascular Diseases",
+ "China",
+ "Aged, 80 and over",
+ "Longitudinal Studies",
+ "Proportional Hazards Models",
+ "Longevity",
+ "Mortality",
+ "Middle Aged",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39717954",
+ "Title": "Molecular medicine reports",
+ "ArticleTitle": "Insights into renal damage in hyperuricemia: Focus on renal protection (Review).",
+ "Abstract": "The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction\u2011associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage. A number of randomized controlled clinical trials have investigated the effectiveness of UA\u2011lowering therapies in preventing kidney disease progression. The present review provided fundamental insights into the pathogenesis, principles and therapeutic approaches for managing hyperuricemia in patients with aforementioned diseases and assesses the effect of uric acid\u2011lowering therapy on diabetic nephropathy, systemic lupus erythematosus, CKD, CVD and obesity progression.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hyperuricemia",
+ "Uric Acid",
+ "Renal Insufficiency, Chronic",
+ "Kidney",
+ "Animals",
+ "Obesity",
+ "Diabetes Mellitus, Type 2",
+ "Cardiovascular Diseases",
+ "Gout"
+ ]
+ },
+ {
+ "PMID": "39717783",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Crosstalk between periodontitis and cardiovascular risk.",
+ "Abstract": "Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Cardiovascular Diseases",
+ "Heart Disease Risk Factors",
+ "Periodontitis"
+ ]
+ },
+ {
+ "PMID": "39717036",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Added sugar intake and its associations with incidence of seven different cardiovascular diseases in 69,705 Swedish men and women.",
+ "Abstract": "The findings suggest that the associations between added sugar intake and cardiovascular diseases vary by disease and source of added sugar. The findings emphasize the adverse health effects of sweetened beverage consumption and indicate higher cardiovascular diseases risks with lower treats intake, which warrants further investigation.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Sweden",
+ "Middle Aged",
+ "Female",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Aged, 80 and over",
+ "Incidence",
+ "Surveys and Questionnaires",
+ "Risk Factors",
+ "Sugar-Sweetened Beverages",
+ "Diet",
+ "Dietary Sugars"
+ ]
+ },
+ {
+ "PMID": "39717032",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Association between phenotypic age and mortality risk in individuals with obesity: a retrospective cohort study.",
+ "Abstract": "PAA is an independent predictor of all-cause, cardiovascular, and cancer mortality in obese individuals. This study highlights the importance of PAA in mortality risk assessment and health management in the obese population.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Obesity",
+ "Middle Aged",
+ "Adult",
+ "Retrospective Studies",
+ "Neoplasms",
+ "Nutrition Surveys",
+ "Cardiovascular Diseases",
+ "Phenotype",
+ "Proportional Hazards Models",
+ "Risk Factors",
+ "Cause of Death",
+ "Aged",
+ "Age Factors",
+ "Body Mass Index",
+ "Kaplan-Meier Estimate"
+ ]
+ },
+ {
+ "PMID": "39716258",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.",
+ "Abstract": "Overall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers",
+ "Blood Glucose",
+ "Cardiovascular Diseases",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus, Type 2",
+ "Insulin Resistance",
+ "Metabolic Syndrome",
+ "Triglycerides"
+ ]
+ },
+ {
+ "PMID": "39715781",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association of life's essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease.",
+ "Abstract": "The American Heart Association has updated the cardiovascular health (CVH) assessment tool, referred to as the Life's Essential 8 (LE8). Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease worldwide and is linked to an elevated risk of mortality. We aimed to explore the association of LE8 with all cause and cause-specific mortality in MASLD in a prospective cohort study. A total of 10,050 participants with MASLD from the NHANES 2005-2018 dataset were included in the study. LE8 was evaluated by combining four health behaviors and four health factors, with scores of 0-49 categorized as low CVH, 50-79 as moderate CVH, and 80-100 as high CVH. In the fully adjusted model, each one-point increase in the LE8 score corresponded to a 2.7, 2.7, and 1.6% decrease in all-cause, CVD, and cancer mortality risk, respectively, in people with MASLD. Compared to low CVH, being in moderate/high CVH was negatively associated with most mortality outcomes, while health factors lost significant association with cancer mortality.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Prospective Studies",
+ "Risk Factors",
+ "Adult",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Fatty Liver",
+ "Cause of Death",
+ "Metabolic Diseases",
+ "Nutrition Surveys"
+ ]
+ },
+ {
+ "PMID": "39715477",
+ "Title": "Neurology",
+ "ArticleTitle": "Risk of Cardiovascular Diseases After Nonfocal Transient Neurologic Attacks in the Elderly: The Rotterdam Study.",
+ "Abstract": "In this study, participants with nonfocal TNA did not have a subsequently elevated risk of CVD when compared with their matched counterparts, which contrasts with the elevated risk of stroke following a TIA. In the absence of other indications, initiating secondary prevention specifically after nonfocal TNA seems unwarranted.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Aged",
+ "Ischemic Attack, Transient",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Netherlands",
+ "Cohort Studies",
+ "Risk Factors",
+ "Aged, 80 and over",
+ "Stroke"
+ ]
+ },
+ {
+ "PMID": "39715341",
+ "Title": "Endocrinology",
+ "ArticleTitle": "GLP-1 and Its Analogs: Does Sex Matter?",
+ "Abstract": "While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeutics, glucagon-like peptide 1 (GLP-1) analogs (eg, semaglutide), shows promise at curbing both diseases. This review addresses the topic of sex differences in the endogenous and therapeutic actions of GLP-1 and its analogs. Work on sex differences in human studies and animal research is reviewed. Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted. Moreover, recent clinical evidence of sex differences in the therapeutic effects of GLP-1 analogs in obesity, diabetes, and cardiovascular disease are discussed. Lastly, we review evidence for the role of GLP-1 analogs in mood and reproductive function, with particular attention to sex differences. Overall, while we did not find evidence for many qualitative sex differences in the therapeutic effect of clinically approved GLP-1 analogs, a growing body of literature highlights quantitative sex differences in the response to GLP-1 and its analogs as well as an interaction of these therapeutics with estrogens. What also clearly emerges is the paucity of data in female animal models or women in very basic aspects of the science of GLP-1-gaps that should be urgently mended, given the growing popularity of these medications, especially in women.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glucagon-Like Peptide 1",
+ "Animals",
+ "Female",
+ "Male",
+ "Sex Characteristics",
+ "Obesity",
+ "Glucagon-Like Peptides",
+ "Hypoglycemic Agents",
+ "Sex Factors",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39714500",
+ "Title": "Giornale italiano di cardiologia (2006)",
+ "ArticleTitle": "[Potassium role in the human body and clinical implications of hyperkalemia].",
+ "Abstract": "Potassium is the most represented intracellular electrolyte in the human body. Its extracellular levels are maintained within strict limits through different mechanisms, which constitute the homeostasis of potassium. Hyperkalemia is the most common electrolyte disorder in patients with cardiovascular disease. Although with different levels of severity, it carries an increased risk of hospitalization, cardiovascular morbidity and mortality. Hyperkalemia may also be an important cause of discontinuation or impossibility of titration of fundamental therapies in the cardiology patient. The principal aim of this review is to analyze the mechanisms underlying hyperkalemia, as well as to summarize its epidemiology, risk factors, monitoring methodologies and electrophysiological and electrocardiographic effects, providing just only few essential elements of therapy. In this way the physician, and especially the cardiologist, can have an adequate knowledge for its management in clinical practice.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hyperkalemia",
+ "Potassium",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Electrocardiography"
+ ]
+ },
+ {
+ "PMID": "39714498",
+ "Title": "Giornale italiano di cardiologia (2006)",
+ "ArticleTitle": "[Multidisciplinary and multiprofessional care to multimorbid chronic patients with cardiovascular disease: the experience of the Azienda Sanitaria Universitaria Giuliano Isontina].",
+ "Abstract": "The world of chronic non-communicable diseases is progressively growing epidemiologically, requiring a significant commitment of resources, continuity of care, and strong integration between healthcare professionals and care settings. The National Recovery and Resilience Plan, in the Ministerial Decree 77 of 23/5/2022, identifies Community Homes as the privileged location for providing integrated, multidisciplinary and multiprofessional interventions, involving specialists and nursing clinics, general practitioners and district structures, utilizing all the necessary technological equipment, including digital platforms for telemedicine. In this context, cardiology is facing a complicated challenge: cardiologists must take care of patients with cardiovascular diseases who have also complex comorbidities and are required to extend their knowledge beyond the specific, sometimes super-specialistic, cardiovascular field, to avoid fragmentation, redundancy, and potential conflicts in the diagnostic-therapeutic care pathways. The Territorial Specialist Department, recently created in the Azienda Sanitaria Universitaria Giuliano Isontina, aims to promote the so-called \"value-based medicine\", that is, an effective yet sustainable medicine in both economic and social terms, reconciling guidelines with the actual needs of the patient. The ultimate goal is to implement an initiative-based medicine program with systematic stratification of patients at greater risk/complexity for a more efficient, appropriate and sustainable clinical governance.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Patient Care Team",
+ "Chronic Disease",
+ "Italy",
+ "Multimorbidity",
+ "Telemedicine",
+ "Cardiology"
+ ]
+ },
+ {
+ "PMID": "39714021",
+ "Title": "Journal of primary care & community health",
+ "ArticleTitle": "Metabolic Syndrome: An Updated Review on Diagnosis and Treatment for Primary Care Clinicians.",
+ "Abstract": "Metabolic syndrome is an independent risk factor for many poor health outcomes. Its individual components should be treated with medication and behavioral changes to reduce cardiovascular risk and prevent diabetes and its complications. More research is needed on how to treat the syndrome itself. A diagnosis of metabolic syndrome may be useful for motivating patients toward lifestyle changes, though more research is needed on how to treat the syndrome versus its components.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Exercise",
+ "Life Style",
+ "Metabolic Syndrome",
+ "Primary Health Care",
+ "Risk Factors",
+ "Weight Loss"
+ ]
+ },
+ {
+ "PMID": "39713140",
+ "Title": "PeerJ",
+ "ArticleTitle": "Ferroptosis and its impact on common diseases.",
+ "Abstract": "Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer's disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Ferroptosis",
+ "Humans",
+ "Neoplasms",
+ "Lipid Peroxidation",
+ "Reperfusion Injury",
+ "Cardiovascular Diseases",
+ "Inflammatory Bowel Diseases",
+ "Alzheimer Disease",
+ "Iron",
+ "Acute Kidney Injury",
+ "Stroke",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39712314",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "The impact of meteorological conditions on cardiovascular and cerebrovascular diseases in different microclimatic zones of low-latitude mountainous areas.",
+ "Abstract": "Our findings delineated the common characteristics of the effect on the incidence of CVD of meteorological environments in various microclimate zones, and clarified the influence of minimum temperature and TCN exhibited spatial heterogeneity, Which may be assistance for meteorological risk forecasting in CVD prevention and control.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Incidence",
+ "Microclimate",
+ "China",
+ "Cerebrovascular Disorders",
+ "Meteorological Concepts",
+ "Temperature",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39711839",
+ "Title": "The Pan African medical journal",
+ "ArticleTitle": "An audit of the establishment of a cardiac magnetic resonance imaging service in a public tertiary hospital setting in the Western Cape Province of South Africa.",
+ "Abstract": "the recently established, functional cardiovascular magnetic resonance imaging service at Tygerberg Hospital serves a unique patient population with a comparatively differently distributed cardiac disease spectrum, contributing to research diversity.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "South Africa",
+ "Tertiary Care Centers",
+ "Retrospective Studies",
+ "Adult",
+ "Male",
+ "Middle Aged",
+ "Magnetic Resonance Imaging",
+ "Young Adult",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Adolescent",
+ "Hospitals, Public",
+ "Contrast Media",
+ "Aged, 80 and over",
+ "Heart Diseases",
+ "Child",
+ "Child, Preschool",
+ "Medical Audit"
+ ]
+ },
+ {
+ "PMID": "39710789",
+ "Title": "European journal of medical research",
+ "ArticleTitle": "Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease.",
+ "Abstract": "The gut microbiota is a complex and dynamic ecosystem that plays a crucial role in human health and disease, including obesity, diabetes, cardiovascular diseases, neurodegenerative diseases, inflammatory bowel disease, and cancer. Chronic inflammation is a common feature of these diseases and is closely related to angiogenesis (the process of forming new blood vessels), which is often dysregulated in pathological conditions. Inflammation potentially acts as a central mediator. This abstract aims to elucidate the connection between the gut microbiota and angiogenesis in various diseases. The gut microbiota influences angiogenesis through various mechanisms, including the production of metabolites that directly or indirectly affect vascularization. For example, short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate are known to regulate immune responses and inflammation, thereby affecting angiogenesis. In the context of cardiovascular diseases, the gut microbiota promotes atherosclerosis and vascular dysfunction by producing trimethylamine N-oxide (TMAO) and other metabolites that promote inflammation and endothelial dysfunction. Similarly, in neurodegenerative diseases, the gut microbiota may influence neuroinflammation and the integrity of the blood-brain barrier, thereby affecting angiogenesis. In cases of fractures and wound healing, the gut microbiota promotes angiogenesis by activating inflammatory responses and immune effects, facilitating the healing of tissue damage. In cancer, the gut microbiota can either inhibit or promote tumor growth and angiogenesis, depending on the specific bacterial composition and their metabolites. For instance, some bacteria can activate inflammasomes, leading to the production of inflammatory factors that alter the tumor immune microenvironment and activate angiogenesis-related signaling pathways, affecting tumor angiogenesis and metastasis. Some bacteria can directly interact with tumor cells, activating angiogenesis-related signaling pathways. Diet, as a modifiable factor, significantly influences angiogenesis through diet-derived microbial metabolites. Diet can rapidly alter the composition of the microbiota and its metabolic activity, thereby changing the concentration of microbial-derived metabolites and profoundly affecting the host's immune response and angiogenesis. For example, a high animal protein diet promotes the production of pro-atherogenic metabolites like TMAO, activating inflammatory pathways and interfering with platelet function, which is associated with the severity of coronary artery plaques, peripheral artery disease, and cardiovascular diseases. A diet rich in dietary fiber promotes the production of SCFAs, which act as ligands for cell surface or intracellular receptors, regulating various biological processes, including inflammation, tissue homeostasis, and immune responses, thereby influencing angiogenesis. In summary, the role of the gut microbiota in angiogenesis is multifaceted, playing an important role in disease progression by affecting various biological processes such as inflammation, immune responses, and multiple signaling pathways. Diet-derived microbial metabolites play a crucial role in linking the gut microbiota and angiogenesis. Understanding the complex interactions between diet, the gut microbiota, and angiogenesis has the potential to uncover novel therapeutic targets for managing these conditions. Therefore, interventions targeting the gut microbiota and its metabolites, such as through fecal microbiota transplantation (FMT) and the application of probiotics to alter the composition of the gut microbiota and enhance the production of beneficial metabolites, present a promising therapeutic strategy.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Neovascularization, Pathologic",
+ "Neoplasms",
+ "Inflammation",
+ "Cardiovascular Diseases",
+ "Animals",
+ "Neurodegenerative Diseases",
+ "Angiogenesis"
+ ]
+ },
+ {
+ "PMID": "39710702",
+ "Title": "Journal of translational medicine",
+ "ArticleTitle": "Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer.",
+ "Abstract": "The identification of ferroptosis represents a pivotal advancement in the field of cell death research, revealing an entirely novel mechanism of cellular demise and offering new insights into the initiation, progression, and therapeutic management of various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments in the antioxidant defense system, culminating in membrane rupture and consequent cell death. Studies have associated ferroptosis with a wide range of diseases, and by enhancing our comprehension of its underlying mechanisms, we can formulate innovative therapeutic strategies, thereby providing renewed hope for patients.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Ferroptosis",
+ "Humans",
+ "Neurodegenerative Diseases",
+ "Cardiovascular Diseases",
+ "Neoplasms",
+ "Animals",
+ "Molecular Targeted Therapy"
+ ]
+ },
+ {
+ "PMID": "39710576",
+ "Title": "Gut microbes",
+ "ArticleTitle": "Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project.",
+ "Abstract": "The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy's impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2\u2009months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, ",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Cross-Over Studies",
+ "Inflammation",
+ "Endotoxemia",
+ "Cardiovascular Diseases",
+ "Cardiometabolic Risk Factors",
+ "Diet",
+ "Polyphenols",
+ "Edible Grain",
+ "Feces",
+ "Bacteria",
+ "Fatty Acids, Omega-3",
+ "Dietary Fiber",
+ "Intestines"
+ ]
+ },
+ {
+ "PMID": "39710465",
+ "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
+ "ArticleTitle": "[The correlation between allergic diseases and cardiovascular disease incidence].",
+ "Abstract": "Allergic reactions are abnormal responses of the immune system to specific allergens, typically resulting in the release of inflammatory mediators and tissue damage. Cardiovascular diseases are common conditions that contribute significantly to increased mortality rates, with inflammation-induced tissue damage playing a crucial role in their pathogenesis. Allergic reactions are associated with various aspects of cardiovascular diseases, such as hypertension, atherosclerosis, and cardiac remodeling. Certain allergic conditions may increase the risk of cardiovascular disease onset. This article aims to explore the role of inflammatory mediators in allergic reactions within the pathophysiology of common cardiovascular diseases. By doing so, it seeks to uncover potential links between allergic reactions and cardiovascular diseases, offering new insights for the prevention and treatment of related conditions.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Hypersensitivity",
+ "Incidence"
+ ]
+ },
+ {
+ "PMID": "39709856",
+ "Title": "Health & place",
+ "ArticleTitle": "Association between ambient temperatures and cardiovascular disease: A time series analysis using emergency ambulance dispatches in Chongqing, China, 2019-2021.",
+ "Abstract": "Ambient temperature is significantly associated with the risk of CVD, with elderly patients, especially females, being a high-risk subgroup. Governments need to formulate localized health policies that address regional climate patterns and population vulnerabilities. As one of the famous \"Furnace Cities\", Chongqing's measures for coping with hot environments can serve as a reference. Nonetheless, improving our understanding and preparation for cold weather is also crucial. Public warning systems should be improved, and local heating strategies for vulnerable groups should be developed to minimize the negative risk of extreme cold temperatures to the public.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "China",
+ "Middle Aged",
+ "Ambulances",
+ "Aged",
+ "Adult",
+ "Emergency Medical Dispatch",
+ "Temperature",
+ "Incidence",
+ "Adolescent",
+ "Child"
+ ]
+ },
+ {
+ "PMID": "39709670",
+ "Title": "European journal of cancer (Oxford, England : 1990)",
+ "ArticleTitle": "Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors.",
+ "Abstract": "GLP1a use in cancer patients with T2DM receiving ICIs was associated with reduced MACE and all-cause mortality without an increased risk in serious adverse events.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Immune Checkpoint Inhibitors",
+ "Retrospective Studies",
+ "Neoplasms",
+ "Aged",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Glucagon-Like Peptide 1",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39709650",
+ "Title": "Clinical nutrition (Edinburgh, Scotland)",
+ "ArticleTitle": "Stearic acid metabolism in human health and disease.",
+ "Abstract": "Named after the Greek term for \"hard fat\", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis. Similar to palmitate, stearic acid serves as a primary substrate for the stearoyl coenzyme A desaturase, which catalyzes the conversion of stearate to oleate and is involved in the synthesis of triglyceride and other complex lipids. Additionally, stearic acid functions as a vital signaling molecule in pathological processes such as cardiovascular diseases, diabetes development, liver injury and even nervous system disorders. Therefore, we conduct a comprehensive review of stearic acid, summarizing its role in various diseases and attempting to provide a systematic overview of its homeostasis, physiological functions, and pathological process. From a medical standpoint, we also explore potential applications and discuss stearic acid as a potential therapeutic target for the treatment of human diseases.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Energy Metabolism",
+ "Lipid Metabolism",
+ "Signal Transduction",
+ "Stearic Acids",
+ "Stearoyl-CoA Desaturase"
+ ]
+ },
+ {
+ "PMID": "39709627",
+ "Title": "Expert opinion on pharmacotherapy",
+ "ArticleTitle": "Advances in the pharmacological management of hyperlipidemia through the use of combination therapies.",
+ "Abstract": "Combination therapy for LDL-C in dual combinations is well validated. Data for intervention on triglycerides is limited to icosapent ethyl, but this may exert effects independent of lipids. New drugs targeting triglycerides through apolipoprotein C3 and angiopoietin-like peptides are in development. Studies on combination therapy raising HDL-C have generally disappointed, though cholesterol ester transfer protein (CETP) inhibition remains a target. Lipoprotein (a) is recognized as a CVD risk factor and effective therapies are in development but results on CVD events are lacking.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Drug Therapy, Combination",
+ "Hyperlipidemias",
+ "Hypolipidemic Agents",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Cardiovascular Diseases",
+ "Cholesterol, LDL",
+ "Animals",
+ "Triglycerides"
+ ]
+ },
+ {
+ "PMID": "39709554",
+ "Title": "Gut microbes",
+ "ArticleTitle": "Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.",
+ "Abstract": "The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained\u2009<\u200910% of the proteome variance. However, unsupervised human protein-based clustering analysis revealed two distinct CVD risk clusters (low-risk and high-risk) with different blood pressure (by 9\u2009mmHg) and sex-dependent dietary potassium and fiber intake. In the human proteome, the low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated with neutrophil extracellular trap formation and auto-immune diseases. In the microbial proteome, the low-risk group had higher expression of phosphate acetyltransferase that produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes in heart failure patients and long-term risk of cardiovascular events in a large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms that may underlie risk factors for CVD.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Feces",
+ "Gastrointestinal Microbiome",
+ "Male",
+ "Female",
+ "Proteomics",
+ "Middle Aged",
+ "Heart Failure",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Adult",
+ "Proteome",
+ "Bacteria",
+ "Risk Factors",
+ "Diet"
+ ]
+ },
+ {
+ "PMID": "39709470",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.",
+ "Abstract": "Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated with widespread vascular disease affecting both the kidney and the heart from an early stage. However, the risk of diabetic nephropathy in people with type 1 diabetes is strongly genetically determined, as documented in familial transmission studies. The search for the underlying genes has been extensive, using specific hypotheses, sibling linkage studies and genome-wide association studies (GWAS). The role of the angiotensinI-converting enzyme/kininase II (ACE) gene and genetic variability in ACE levels as a susceptibility and prognostic factor for diabetic nephropathy has been well documented in people with type 1 diabetes. The ACE gene insertion/deletion polymorphism, which is associated with plasma and tissue ACE levels, has been the most studied genomic variant in diabetic nephropathy. Recently, this polymorphism has also been associated with longevity in people with type 1 diabetes. The ACE I/D polymorphism has also been associated with vascular, extra-renal complications including myocardial infarction and lower-limb amputation in this population. Other genes and loci have been identified in linkage studies and GWAS, such as the COL4A3 gene or a region on chromosome 3q with the adiponectin gene. Replication was not always attempted and was rarely achieved, even for GWAS. Overall, effect sizes remain modest and no major gene has been identified, despite the strength of the genetic effect in transmission studies. We searched bibliographic databases for studies reporting genomic variants associated with diabetic nephropathy and meta-analyses of such studies. We selected important relevant studies for further discussion in this narrative review. This brief review attempts to summarise the current knowledge on the genetics of diabetic nephropathy and associated cardiovascular disease in people with type 1 diabetes, and discusses some conceptual and methodological issues relevant to the interpretation of past studies and the design of future ones.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Genetic Predisposition to Disease",
+ "Diabetic Nephropathies",
+ "Diabetes Mellitus, Type 1",
+ "Peptidyl-Dipeptidase A",
+ "Cardiovascular Diseases",
+ "Phenotype",
+ "Genome-Wide Association Study",
+ "Risk Factors",
+ "Polymorphism, Genetic"
+ ]
+ },
+ {
+ "PMID": "39709437",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation.",
+ "Abstract": "A high level potassium intake estimated from urine potassium excretion was independently associated with a low risk of MACE in patients with type 2 diabetes. Increasing potassium intake may be a potential effective strategy for cardiovascular risk reduction beyond controlling traditional risk factors.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Male",
+ "Prospective Studies",
+ "Middle Aged",
+ "Risk Assessment",
+ "Aged",
+ "Time Factors",
+ "Potassium, Dietary",
+ "Cardiovascular Diseases",
+ "Reproducibility of Results",
+ "Prognosis",
+ "Biomarkers",
+ "Risk Factors",
+ "Protective Factors",
+ "Albuminuria",
+ "Urinalysis",
+ "Recommended Dietary Allowances"
+ ]
+ },
+ {
+ "PMID": "39709369",
+ "Title": "BMC pulmonary medicine",
+ "ArticleTitle": "Relationship between systemic immune-inflammation index and long-term all-cause and cause-specific mortality among adult asthma patients: a population-based study.",
+ "Abstract": "Clinical trial number not applicable.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Asthma",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "Inflammation",
+ "Cause of Death",
+ "Cardiovascular Diseases",
+ "Aged",
+ "United States",
+ "Proportional Hazards Models",
+ "Kaplan-Meier Estimate",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39709364",
+ "Title": "BMC surgery",
+ "ArticleTitle": "Development of a predictive model for postoperative major adverse cardiovascular events in elderly patients undergoing major abdominal surgery.",
+ "Abstract": "The nomogram risk prediction model based on SPPB and clinical indicators can better predict the occurrence of MACEs and can guide preoperative intervention and help to improve perioperative management.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Female",
+ "Male",
+ "Postoperative Complications",
+ "Cardiovascular Diseases",
+ "Abdomen",
+ "Risk Assessment",
+ "Nomograms",
+ "Retrospective Studies",
+ "Aged, 80 and over",
+ "Risk Factors",
+ "Predictive Value of Tests",
+ "ROC Curve",
+ "Incidence"
+ ]
+ },
+ {
+ "PMID": "39709110",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes.",
+ "Abstract": "Higher eGDR level was associated with lower risks of all-cause and cardiovascular deaths in a linear dose-response manner among non-diabetic females, while L-shaped relationships were observed among non-diabetic males.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Insulin Resistance",
+ "Adult",
+ "Blood Glucose",
+ "Nutrition Surveys",
+ "Sex Factors",
+ "Risk Factors",
+ "Cause of Death",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39708996",
+ "Title": "Preventive medicine",
+ "ArticleTitle": "Association between physical activity-related metabolic signature and cardiometabolic diseases and multimorbidity: A cohort study from UK biobank.",
+ "Abstract": "Physical activity-related metabolic signature is linked to reduced risks of CMDs and CMM. We once again emphasize the importance of physical activity for CMDs prevention from a metabolic perspective, especially for individuals at high genetic risk.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "United Kingdom",
+ "Female",
+ "Male",
+ "Exercise",
+ "Middle Aged",
+ "Prospective Studies",
+ "Multimorbidity",
+ "Diabetes Mellitus, Type 2",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Biological Specimen Banks",
+ "Coronary Disease",
+ "Genetic Predisposition to Disease",
+ "Stroke",
+ "Adult",
+ "UK Biobank"
+ ]
+ },
+ {
+ "PMID": "39708590",
+ "Title": "Maturitas",
+ "ArticleTitle": "Obstructive sleep apnea syndrome (OSAS) in women: A forgotten cardiovascular risk factor.",
+ "Abstract": "Sleep-disordered breathing is a highly prevalent disorder with negative impact on healthcare systems worldwide. This condition has detrimental effects on cardiovascular health and quality of life, and is frequently associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes and atrial fibrillation. Nevertheless, it remains frequently undiagnosed and undertreated, especially in specific populations. Studies on sleep-disordered breathing have been conducted mainly on male patients, and the prevalence and severity of this disorder in women are underestimated. Recently, some clinical and laboratory evidence has highlighted the epidemiological and pathophysiological differences between men and women with sleep-disordered breathing. In this review, we discuss sex-related mechanisms of sleep-disordered breathing in frequently associated disorders, to improve clinical understanding of this condition and to simplify the practical application of targeted interventions. The aim is to improve prognosis among female patients and guarantee a better quality of life and a reduction in healthcare costs.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Sleep Apnea, Obstructive",
+ "Cardiovascular Diseases",
+ "Quality of Life",
+ "Heart Disease Risk Factors",
+ "Sex Factors",
+ "Risk Factors",
+ "Prevalence",
+ "Male"
+ ]
+ },
+ {
+ "PMID": "39708140",
+ "Title": "Rheumatology international",
+ "ArticleTitle": "Prevalence of comorbidities and cardiovascular risk factor management in hand osteoarthritis: a cross-sectional study.",
+ "Abstract": "We found an increased CV risk in hand osteoarthritis patients who had an insufficient LDL cholesterol target achievement. Hand osteoarthritis patients appear to have a pro-atherogenic profile. These results suggest that CV risk factors should be assessed in patients with hand osteoarthritis and managed according to recommended guidelines.",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Osteoarthritis",
+ "Middle Aged",
+ "Aged",
+ "Heart Disease Risk Factors",
+ "Prevalence",
+ "Hand Joints",
+ "Comorbidity",
+ "Cardiovascular Diseases",
+ "Hand Strength",
+ "Quality of Life",
+ "Risk Factors",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors"
+ ]
+ },
+ {
+ "PMID": "39707266",
+ "Title": "BMC pulmonary medicine",
+ "ArticleTitle": "Effectiveness of high-intensity inspiratory muscle training, and resistance and aerobic exercise for cardiovascular health in chronic obstructive pulmonary disease (HIRAC-COPD): a randomized controlled trial protocol.",
+ "Abstract": "ChiCTR2400085483. Date of registration: June 7, 2024. https://www.chictr.org.cn/index.aspx .",
+ "Predictions": [
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Vascular Stiffness",
+ "Breathing Exercises",
+ "Randomized Controlled Trials as Topic",
+ "Pulse Wave Analysis",
+ "Resistance Training",
+ "Cardiovascular Diseases",
+ "Exercise",
+ "Quality of Life",
+ "Respiratory Muscles",
+ "Aged",
+ "Ankle Brachial Index",
+ "Male",
+ "Exercise Therapy",
+ "Middle Aged"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/chronic_respiratory_disease.json b/model/dataset/chronic_respiratory_disease.json
new file mode 100644
index 0000000000000000000000000000000000000000..168afb69261512a7b6658d53aa7c949813b2334c
--- /dev/null
+++ b/model/dataset/chronic_respiratory_disease.json
@@ -0,0 +1,2346 @@
+[
+ {
+ "PMID": "39738021",
+ "Title": "Nature communications",
+ "ArticleTitle": "Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.",
+ "Abstract": "Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China. An integrated exposure-response model was used to estimate the association between OP and EPFRs and hospitalization during SDS. EPFRs were strongly associated with circulatory (3.05%; 95% confidence interval [CI]: 1.01%, 4.08%) and respiratory (2.02%; 95% CI: 1.01%, 4.08%) diseases with each increase of 10",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Dust",
+ "Humans",
+ "Hospitalization",
+ "Free Radicals",
+ "Air Pollutants",
+ "Oxidative Stress",
+ "Particulate Matter",
+ "China",
+ "Environmental Exposure",
+ "Beijing",
+ "Sand",
+ "Respiratory Tract Diseases",
+ "Oxidation-Reduction",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39729927",
+ "Title": "Cancer genetics",
+ "ArticleTitle": "Machine learning analysis of CD4+ T cell gene expression in diverse diseases: insights from cancer, metabolic, respiratory, and digestive disorders.",
+ "Abstract": "CD4",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "CD4-Positive T-Lymphocytes",
+ "Neoplasms",
+ "Machine Learning",
+ "Digestive System Diseases",
+ "Metabolic Diseases",
+ "Respiratory Tract Diseases",
+ "Gene Expression Profiling",
+ "Respiration Disorders"
+ ]
+ },
+ {
+ "PMID": "39729438",
+ "Title": "PloS one",
+ "ArticleTitle": "Implementing digital respiratory technologies for people with respiratory conditions: A protocol for a scoping review.",
+ "Abstract": "The value of 'data-enabled', digital healthcare is evolving rapidly, as demonstrated in the COVID-19 pandemic, and its successful implementation remains complex and challenging. Harmonisation (within/between healthcare systems) of infrastructure and implementation strategies has the potential to promote safe, equitable and accessible digital healthcare, but guidance for implementation is lacking. Using respiratory technologies as an example, our scoping review process will capture and review the published research between 12th December 2013 to 12th December 2023. Following standard methodology (Arksey and O'Malley), we will search for studies published in ten databases: MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane Library, Web of Science, Scopus, IEEE Xplore, CABI Global Health, and WHO Medicus. Our search strategy will use the terms: digital health, respiratory conditions, and implementation. Using Covidence, screening of abstracts and full texts will be undertaken by two independent reviewers, with conflicts resolved by a third reviewer. Data will be extracted into a pilot-tested data extraction table for charting, summarising and reporting the results. We will conduct stakeholder meetings throughout to discuss the themes emerging from implementation studies and support interpretation of findings in the light of their experience within their own networks and organisations. The findings will inform the future work within the ERS CONNECT clinical research collaboration and contribute to policy statements to promote a harmonised framework for digital transformation of respiratory healthcare.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Digital Technology",
+ "Respiratory Tract Diseases",
+ "Telemedicine",
+ "Scoping Reviews As Topic"
+ ]
+ },
+ {
+ "PMID": "39724617",
+ "Title": "Problemy radiatsiinoi medytsyny ta radiobiolohii",
+ "ArticleTitle": "LEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).",
+ "Abstract": "The overall mortality of Chornobyl clean-up workers from non-tumor diseases tends to increase. Theresults of the risk analysis of dose dependent mortality in the Chornobyl clean-up workers cohort showed a highersensitivity to ionizing radiation of persons of the younger age group (18-39 years old at the date of the accident).The most dangerous period of relative dose-dependent risk of death of Chornobyl clean-up workers due to non-tumordiseases was established - 6-10 years after radiation exposure for all dose subgroups (from 0.05 Gy to 0.7 Gy) relative to the subgroup with a radiation dose < 0.05 Gy.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chernobyl Nuclear Accident",
+ "Male",
+ "Adult",
+ "Occupational Exposure",
+ "Middle Aged",
+ "Ukraine",
+ "Radiation Exposure",
+ "Radiation Dosage",
+ "Occupational Diseases",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Gamma Rays",
+ "Radiation Injuries",
+ "Risk Assessment",
+ "Cerebrovascular Disorders",
+ "Myocardial Infarction",
+ "Respiratory Tract Diseases",
+ "Digestive System Diseases",
+ "Emergency Responders",
+ "Adolescent",
+ "Cardiomyopathies"
+ ]
+ },
+ {
+ "PMID": "39710468",
+ "Title": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
+ "ArticleTitle": "[Analysis of the distribution characteristics of allergen sIgE detection in patients with respiratory and skin mucosal diseases in a hospital in Shanghai City from 2022 to 2023].",
+ "Abstract": "Analyzing the distribution characteristics of allergen sIgE in the serum of patients with respiratory and skin mucosal diseases in Shanghai City, and to provide epidemiological characteristics and diagnostic basis for the prevention and treatment of allergic respiratory and dermo-mucous diseases in Shanghai City. Adopting cross-sectional research, a total of 3 822 patients who received treatment in Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2022 to July 2023 due to respiratory diseases or skin and dermo-mucous symptoms were included. Among them, there were 1 456 males and 2 366 females, with an age range of 1-97 years old. The median age (interquartile range) was 33 (27, 44) years old. The sIgE was detected by using immunoblotting. Statistical analysis was conducted using SPSS 22.0 software, and the comparison of count data (rates) between groups was conducted using ",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Allergens",
+ "Adult",
+ "Adolescent",
+ "Child",
+ "China",
+ "Middle Aged",
+ "Child, Preschool",
+ "Cross-Sectional Studies",
+ "Young Adult",
+ "Infant",
+ "Aged",
+ "Immunoglobulin E",
+ "Aged, 80 and over",
+ "Animals",
+ "Skin Diseases",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39707265",
+ "Title": "BMC public health",
+ "ArticleTitle": "Mediating effect of respiratory symptoms on the association between residential distance and the quality of life among residents living near waste incineration plants in Dongguan, Southern China.",
+ "Abstract": "Residential distance from a WIP was significantly associated with QOL, and the association between residential distance and QOL was mediated by respiratory symptoms. Future longitudinal studies on adverse respiratory health effects of exposure to WIP emissions are required using objective assessments.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "China",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Middle Aged",
+ "Incineration",
+ "Adult",
+ "Surveys and Questionnaires",
+ "Residence Characteristics",
+ "Aged",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39696118",
+ "Title": "BMC public health",
+ "ArticleTitle": "Short-term exposure to outdoor nitrogen dioxide and respiratory mortality, with high-risk populations: a nationwide time-stratified case-crossover study.",
+ "Abstract": "Numerous existing studies reported the negative impacts of outdoor nitrogen dioxide (NO",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nitrogen Dioxide",
+ "Republic of Korea",
+ "Cross-Over Studies",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Aged, 80 and over",
+ "Environmental Exposure",
+ "Respiratory Tract Diseases",
+ "Air Pollutants",
+ "Young Adult",
+ "Adolescent",
+ "Child, Preschool",
+ "Child",
+ "Air Pollution",
+ "Infant",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39694698",
+ "Title": "BMJ open",
+ "ArticleTitle": "Long term exposure to ambient air pollution and hospital admission burden in Scotland: 16 year prospective population cohort study.",
+ "Abstract": "The results of this study support an association between long term (16\u2009years) exposure to ambient air pollution and increased all cause and cause specific hospital admissions for both physical and mental/behavioural illnesses. The results suggest that interventions on air pollution through stricter environmental regulations could help ease the hospital care burden in Scotland in the long term.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Scotland",
+ "Male",
+ "Female",
+ "Air Pollution",
+ "Prospective Studies",
+ "Middle Aged",
+ "Particulate Matter",
+ "Hospitalization",
+ "Environmental Exposure",
+ "Adult",
+ "Nitrogen Dioxide",
+ "Aged",
+ "Air Pollutants",
+ "Sulfur Dioxide",
+ "Cardiovascular Diseases",
+ "Longitudinal Studies",
+ "Young Adult",
+ "Adolescent",
+ "Respiratory Tract Diseases",
+ "Mental Disorders"
+ ]
+ },
+ {
+ "PMID": "39694558",
+ "Title": "Zhonghua er ke za zhi = Chinese journal of pediatrics",
+ "ArticleTitle": "[Clinical practice guidelines for home nebulization therapy in children with respiratory diseases (2025)].",
+ "Abstract": "",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nebulizers and Vaporizers",
+ "Child",
+ "Administration, Inhalation",
+ "Respiratory Tract Diseases",
+ "Asthma",
+ "Home Care Services",
+ "Practice Guidelines as Topic",
+ "Respiratory Therapy"
+ ]
+ },
+ {
+ "PMID": "39684326",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Mast Cells in Allergic and Non-Allergic Upper Airways Diseases: Sentinel in the Watchtower.",
+ "Abstract": "Mast cells are immune system cells with the most disparate functions, but are also among the least understood. Mast cells are implicated in several known pathological processes, tissue homeostasis, and wound repair. However, they owe their notoriety to allergic diseases, of which they represent the effector cell par excellence. In both allergic and not upper airway pathologies, mast cells play a key role. Exploring the mechanisms through which these cells carry out their physiological and pathological function may help us give a new perspective on existing therapies and identify new ones. A focus will be placed on non-allergic rhinitis, a poorly recognized and often neglected condition with complex management, where the role of the mast cell is crucial in the pathogenetic, clinical, and prognostic aspects.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Mast Cells",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39684250",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System.",
+ "Abstract": "Endocrine-disrupting chemicals (EDCs) are a growing health hazard for humankind and respiratory health in particular. Such chemical compounds are present in the environment and food and may interfere with physiological processes through interference with functions of the endocrine system, making humans more susceptible to various types of diseases. This review aims to discuss the effects of EDCs on the respiratory system. Exposure to EDCs during fetal development and adulthood increases susceptibility to respiratory diseases such as asthma, COPD, and pulmonary fibrosis. EDCs are both multiple and complex in the ways they can act. Indeed, these chemicals may induce oxidative stress, modify cell proliferation and differentiation, interfere with tissue repair, and modulate the inflammatory response. Moreover, EDCs may also break the integrity of the blood-air barrier, allowing noxious substances to penetrate into the lung and thus enhancing the opportunity for infection. In conclusion, the scientific evidence available tends to indicate that EDCs exposure is strongly linked to the initiation of respiratory disease. Further research will be important in discovering the underlying molecular mechanisms and devising preventive and therapeutic measures.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Endocrine Disruptors",
+ "Humans",
+ "Respiratory System",
+ "Animals",
+ "Oxidative Stress",
+ "Respiratory Tract Diseases",
+ "Environmental Exposure"
+ ]
+ },
+ {
+ "PMID": "39661886",
+ "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
+ "ArticleTitle": "Violation of vitamin and mineral homeostasis in children with recurrent respiratory diseases.",
+ "Abstract": "Conclusions: Positive correlations were observed with vitamins - Cyanocobalamin (r=0.40, p<0.01), vitamin C (r=0.43, p<0.01), Ferritin (r=0.35, p<0.01), Magnesium (r=0.27, p<0.003). Negative correlations of vitamins, in particular, Folic acid (r=-0.50, p<0.01), vitamin A (r=-0.40, p<0.01) and Phosphorus minerals (r=-0.75 , p<0.01), Sodium (r=-0.51, p<0.01), Potassium (r=-0.24, p=0.008), Chlorine (r=-0.38, p<0 ,01).",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Child",
+ "Male",
+ "Homeostasis",
+ "Minerals",
+ "Vitamins",
+ "Ascorbic Acid",
+ "Respiratory Tract Diseases",
+ "Vitamin D",
+ "Recurrence"
+ ]
+ },
+ {
+ "PMID": "39661885",
+ "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
+ "ArticleTitle": "Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy scheme.",
+ "Abstract": "Conclusions: The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (\u04403<0,01; \u04404<0,01; \u04405<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "Adolescent",
+ "Male",
+ "Antioxidants",
+ "Female",
+ "Ascorbic Acid",
+ "Interleukin-6",
+ "Glutathione Peroxidase",
+ "Hydrocortisone",
+ "Ferritins",
+ "Tumor Necrosis Factor-alpha",
+ "Respiratory Tract Diseases",
+ "Acute Disease"
+ ]
+ },
+ {
+ "PMID": "39659714",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Occupation-related respiratory diseases among sanitary workers in the workplace: a systematic review and meta-analysis.",
+ "Abstract": "The current systematic review and meta-analysis found that ORRD were common among the SWs. Due to numerous risk factors, these illnesses are more prevalent in low-income countries than in industrialized ones. Therefore, to reduce these risks for these groups-especially for street sweepers in low-income countries-government policy changes and other preventive measures are required.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Workplace",
+ "Occupational Diseases",
+ "Respiratory Tract Diseases",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39643329",
+ "Title": "The Lancet. Public health",
+ "ArticleTitle": "Associations of long-term nitrogen dioxide exposure with a wide spectrum of diseases: a prospective cohort study of 0\u00b75 million Chinese adults.",
+ "Abstract": "Wellcome Trust, UK Medical Research Council, Cancer Research UK, British Heart Foundation, National Natural Science Foundation of China, National Key Research and Development Program of China, Sino-British Fellowship Trust, and Kadoorie Charitable Foundation.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Adult",
+ "Prospective Studies",
+ "Nitrogen Dioxide",
+ "China",
+ "Aged",
+ "Environmental Exposure",
+ "Incidence",
+ "Musculoskeletal Diseases",
+ "Cardiovascular Diseases",
+ "Respiratory Tract Diseases",
+ "Air Pollutants",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39642570",
+ "Title": "International immunopharmacology",
+ "ArticleTitle": "Health assessment of sulfur mustard-chemical veterans with various respiratory diseases: The result of a comparative analysis of biological health scores (BHS) through 50 biomarkers.",
+ "Abstract": "The modified multisystem BHS could be useful in the more accurate evaluation of biological health in chronic SM toxicity. The dysregulation observed in the endocrine and metabolic systems underscores the complication of SM toxicity and its extensive consequences on physiological homeostasis.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mustard Gas",
+ "Male",
+ "Biomarkers",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Chemical Warfare Agents",
+ "Veterans",
+ "Middle Aged",
+ "Respiratory Tract Diseases",
+ "Iran"
+ ]
+ },
+ {
+ "PMID": "39640901",
+ "Title": "BioMed research international",
+ "ArticleTitle": "Indigenous Knowledge and Quantitative Analysis of Medicinal Plants Used to Remedy Respiratory Tract Disorders in Mid-Western Tanzania.",
+ "Abstract": "This study is aimed at documenting the indigenous knowledge and quantitative analysis of medicinal plants (MPs) used by traditional health practitioners (THPs) of Urambo District in mid-western Tanzania to manage respiratory tract disorders (RTDs). The ethnomedicinal data were collected using semistructured interviews with 55 THPs using a snowballing technique in the district. The data were analysed for indigenous knowledge among gender, age groups, education status, and experience. Family importance value (FIV), use value (UV), relative frequency of citation (RFC), informant consensus factor (ICF), and Jaccard index (JI) were computed. A total of 42 MPs representing 28 families were recorded being used against RTDs in the district. Fabaceae was the dominant family in terms of species (16.7%) and FIV (84%). Decoction (51.0%) was the preferred technique for preparing remedies, while trees (61.9%) and leaves (38.1%) were the most utilised life form and plant parts, respectively. The RFC in the current study varied from 0.055 (",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Plants, Medicinal",
+ "Humans",
+ "Tanzania",
+ "Male",
+ "Female",
+ "Respiratory Tract Diseases",
+ "Adult",
+ "Middle Aged",
+ "Health Knowledge, Attitudes, Practice",
+ "Medicine, African Traditional",
+ "Aged",
+ "Phytotherapy"
+ ]
+ },
+ {
+ "PMID": "39633457",
+ "Title": "Particle and fibre toxicology",
+ "ArticleTitle": "Airborne micro- and nanoplastics: emerging causes of respiratory diseases.",
+ "Abstract": "Airborne micro- and nanoplastics (AMNPs) are ubiquitously present in human living environments and pose significant threats to respiratory health. Currently, much research has been conducted on the relationship between micro- and nanoplastics (MNPs) and cardiovascular and gastrointestinal diseases, yet there is a clear lack of understanding regarding the link between AMNPs and respiratory diseases. Therefore, it is imperative to explore the relationship between the two. Recent extensive studies by numerous scholars on the characteristics of AMNPs and their relationship with respiratory diseases have robustly demonstrated that AMNPs from various sources significantly influence the onset and progression of respiratory conditions. Thus, investigating the intrinsic mechanisms involved and finding necessary preventive and therapeutic measures are crucial. In this review, we primarily describe the fundamental characteristics of AMNPs, their impact on the respiratory system, and the intrinsic toxic mechanisms that facilitate disease development. It is hoped that this article will provide new insights for further research and contribute to the advancement of human health.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Respiratory Tract Diseases",
+ "Nanoparticles",
+ "Microplastics",
+ "Inhalation Exposure",
+ "Air Pollutants",
+ "Animals",
+ "Respiratory System"
+ ]
+ },
+ {
+ "PMID": "39633418",
+ "Title": "Journal of health, population, and nutrition",
+ "ArticleTitle": "Short-term effects of air pollutants on hospitalization for childhood respiratory diseases in Suzhou City: a time-stratified case-crossover study.",
+ "Abstract": "The short-term exposure to PM",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Hospitalization",
+ "Child",
+ "Male",
+ "Female",
+ "Air Pollutants",
+ "Cross-Over Studies",
+ "Child, Preschool",
+ "COVID-19",
+ "Respiratory Tract Diseases",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Particulate Matter",
+ "Infant",
+ "Sulfur Dioxide",
+ "SARS-CoV-2",
+ "Adolescent",
+ "Nitrogen Dioxide",
+ "Time Factors"
+ ]
+ },
+ {
+ "PMID": "39632975",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Mendelian randomization study on the association of circulating ketone bodies with lung cancer and respiratory diseases.",
+ "Abstract": "The liver produces various ketone bodies (KBs) including 3-Hydroxybutyrate (3-OHB), acetoacetate (AcAc), and acetone, with 3-OHB being the major component. Previous studies have shown that KBs protect against respiratory diseases; however, there is no evidence of a genetic link. To avoid biases existing in traditional observational studies, a two-sample Mendelian randomization (MR) analysis was carried out to investigate genetic causation and novel therapeutic uses for KBs. This study used databases from genome-wide association studies (GWAS) and single nucleotide polymorphisms as instrumental variables for KBs from a recently published metabonomics study (n\u2009=\u2009121,584) and respiratory diseases [lung cancer, n\u2009=\u200985,716; asthma, n\u2009=\u2009127,669; chronic bronchitis, n\u2009=\u2009450,422; chronic obstructive pulmonary disease (COPD), n\u2009=\u2009468,475; FEV",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Lung Neoplasms",
+ "Genome-Wide Association Study",
+ "Ketone Bodies",
+ "Polymorphism, Single Nucleotide",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39620702",
+ "Title": "Current opinion in pulmonary medicine",
+ "ArticleTitle": "The impact of climate change on respiratory health: current understanding and knowledge gaps.",
+ "Abstract": "A better understanding of which components of climate change most impact human health is needed in order to re-define environmental standards. PM 2.5 needs to be broken down by chemical composition to study the differential impacts of different sources of PM 2.5 . The detection and study of climate-related changes in respiratory infectious diseases is in a state of relative infancy.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Climate Change",
+ "Air Pollution",
+ "Particulate Matter",
+ "Environmental Exposure",
+ "Ozone",
+ "Respiratory Tract Diseases",
+ "Air Pollutants"
+ ]
+ },
+ {
+ "PMID": "39617287",
+ "Title": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association",
+ "ArticleTitle": "Dietary exposure to mixtures of chemicals in the first year of life and allergic and respiratory diseases up to 8 years in the French EDEN mother-child cohort.",
+ "Abstract": "Exposure to environmental chemicals has been associated with higher risk of childhood allergies. This study aimed to examine the association between infant's dietary exposure to mixtures of chemicals and allergic and respiratory multimorbidity in childhood. Dietary exposures were assessed at 8 and 12 months in 724 and 745 children of the EDEN cohort. Allergic and respiratory multimorbidity clusters were identified using latent class analyses. Associations between dietary exposure to mixtures of chemicals and allergic clusters were assessed by adjusted multinomial logistic regressions. At 8 months, higher exposure to a mixture of furans, trace elements, dioxins and PAHs was positively associated with the \"asthma only\" cluster, while moderate exposure to a mixture of PAHs, pesticides, PCBs and acrylamide was negatively associated with this cluster. A mixture of PCBs and BFRs was positively associated with the \"multi-morbidity\" cluster. Exposure to a mixture of pesticides and trace elements was positively associated with the \"allergy without asthma\" cluster. At 12-months, higher exposure to a mixture of trace elements and pesticides was positively associated with \"multi-morbidity\" cluster. The differences in findings between the two ages suggest the need for further studies to explore this critical window of chemical exposure and its impact on children's health.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Infant",
+ "Female",
+ "Hypersensitivity",
+ "Male",
+ "France",
+ "Dietary Exposure",
+ "Child",
+ "Cohort Studies",
+ "Child, Preschool",
+ "Pesticides",
+ "Respiratory Tract Diseases",
+ "Environmental Pollutants"
+ ]
+ },
+ {
+ "PMID": "39615506",
+ "Title": "Lancet (London, England)",
+ "ArticleTitle": "Global, regional, and national mortality burden attributable to air pollution from landscape fires: a health impact assessment study.",
+ "Abstract": "Australian Research Council, Australian National Health and Medical Research Council.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Air Pollutants",
+ "Air Pollution",
+ "Cardiovascular Diseases",
+ "Environmental Exposure",
+ "Fires",
+ "Global Burden of Disease",
+ "Global Health",
+ "Health Impact Assessment",
+ "Mortality",
+ "Ozone",
+ "Particulate Matter",
+ "Respiratory Tract Diseases",
+ "Wildfires"
+ ]
+ },
+ {
+ "PMID": "39608993",
+ "Title": "BMJ open",
+ "ArticleTitle": "Hospitalisation patterns for respiratory diseases in Australia: an ecological study.",
+ "Abstract": "Hospital admissions due to diseases of the respiratory system increased significantly in the last two decades in Australia. Male gender and younger age groups were more likely to be hospitalised for respiratory diseases. Strong public health measures are crucial to raising awareness about diseases of the respiratory system and their implications.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Australia",
+ "Adult",
+ "Adolescent",
+ "Hospitalization",
+ "Aged",
+ "Young Adult",
+ "Child",
+ "Respiratory Tract Diseases",
+ "Infant",
+ "Child, Preschool",
+ "Infant, Newborn",
+ "Aged, 80 and over",
+ "Sex Distribution",
+ "Age Distribution"
+ ]
+ },
+ {
+ "PMID": "39607106",
+ "Title": "Cadernos de saude publica",
+ "ArticleTitle": "Identifying high occurrence areas of hospitalization and mortality from respiratory diseases in the Brazilian Legal Amazon: a space-time analysis.",
+ "Abstract": "Respiratory diseases pose a significant threat to the health of the Brazilian population, ranking among the leading causes of hospitalizations and deaths in the country. The most impacted demographics are children, adolescents, and older adults, who respectively have the highest rates of hospitalizations and deaths. An exploratory ecological study was conducted to assess the spatio-temporal distribution of hospitalizations and deaths due to respiratory diseases among children, adolescents, and older adults residing in municipalities in the Brazilian Legal Amazon. Moreover, the study aimed to identify priority municipalities within the detected clusters by employing composite synthetic municipal indices. These indices were estimated based on various socio-environmental and health indicators. The scan analysis identified clusters across various time periods but they mostly aligned with the disease trends in the region. We were able to identify clusters both near metropolitan areas and in remote locations, capturing two distinct patterns of cluster distribution. Moreover, the application of composite synthetic indices enabled a comprehensive identification of priority municipalities, considering various factors relevant to the health conditions of the population in the studied areas.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Brazil",
+ "Hospitalization",
+ "Adolescent",
+ "Spatio-Temporal Analysis",
+ "Child",
+ "Respiratory Tract Diseases",
+ "Young Adult",
+ "Adult",
+ "Socioeconomic Factors",
+ "Child, Preschool",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Aged",
+ "Cluster Analysis",
+ "Infant",
+ "Urban Population",
+ "Space-Time Clustering",
+ "Cities"
+ ]
+ },
+ {
+ "PMID": "39603392",
+ "Title": "Respiratory medicine",
+ "ArticleTitle": "Characteristics of rehabilitation programs for chronic respiratory diseases in Asia: A scoping review.",
+ "Abstract": "The rates of chronic respiratory disease (CRD) is rising in Asia. Pulmonary rehabilitation (PR) has been shown to be a highly efficacious intervention for people with CRD. While PR models are well established in Western countries, environmental, cultural and societal factors may influence how rehabilitation programs for people with CRD are conducted in Asia. This review aims to identify the characteristics of rehabilitation programs for people with CRD within Asia and identify differences between these rehabilitation programs to the recently updated American Thoracic Society (ATS) PR guidelines. Utilising the PRISMA scoping review guidelines, five databases- CINAHL, Medline, Embase, Web of Science and Health and Medical Collection were searched from inception until 13th December 2023. A total of 137 studies (n\u00a0=\u00a019,128) were included in the review. As many as 113 studies (83\u00a0%) included aerobic exercises as part of rehabilitation, only 90 studies (66\u00a0%) included resistance training. Thirty-nine studies included interventions such as Tai Chi, Qigong and Yoga. Comparing to the 2023 ATS PR guidelines, only 22\u00a0% of the included studies evaluated a rehabilitation program that was consistent with the guidelines. Improvement in exercise capacity (76\u00a0%) and quality of life (QOL) (73\u00a0%) were the most frequent outcomes used to evaluate program efficacy. The results suggest that models of rehabilitation varied greatly within the Asia region, with some more heavily adapted to suit the local context as compared to others. Further consideration on how to balance adaptation of PR with fidelity of the intervention needs to be taken.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Asia",
+ "Chronic Disease",
+ "Quality of Life",
+ "Qigong",
+ "Yoga",
+ "Tai Ji",
+ "Resistance Training",
+ "Respiratory Tract Diseases",
+ "Exercise Therapy",
+ "Exercise Tolerance",
+ "Practice Guidelines as Topic"
+ ]
+ },
+ {
+ "PMID": "39578996",
+ "Title": "Journal of cachexia, sarcopenia and muscle",
+ "ArticleTitle": "Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.",
+ "Abstract": "Low grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle-related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Prospective Studies",
+ "Adult",
+ "Aged",
+ "China",
+ "Aged, 80 and over",
+ "Hand Strength",
+ "Respiratory Tract Diseases",
+ "Muscle, Skeletal",
+ "Muscle Strength",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39578779",
+ "Title": "Molecular medicine (Cambridge, Mass.)",
+ "ArticleTitle": "Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases.",
+ "Abstract": "Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member of the Smad family proteins, mainly participating in the bone morphogenetic protein (BMP) signaling pathway in its phosphorylated form. This article will provide a detailed review of Smad5, focusing on its gene characteristics, protein structure, and subcellular localization properties. We will also explore the related signaling pathways and the mechanisms of Smad5 in respiratory diseases, including chronic obstructive pulmonary disease (COPD), bronchial asthma, pulmonary arterial hypertension(PAH), lung cancer, and idiopathic pulmonary fibrosis (IPF). Additionally, the review will cover aspects such as proliferation, differentiation, apoptosis, anti-fibrosis, and mitochondrial function metabolism. In addition, the review will cover aspects of proliferation, differentiation, apoptosis, anti-fibrosis and functional mitochondrial metabolism related to the above topics. Numerous studies suggest that Smad5 may play a unique and important role in the pathogenesis of respiratory system diseases. However, in previous research, Smad5 was mainly used to broadly determine the activation of the BMP signaling pathway, and its own function has not been given much attention. It is worth noting that Smad5 has distinct nuclear-cytoplasmic distribution characteristics different from Smad1 and Smad8. It can undergo significant nuclear-cytoplasmic shuttling when intracellular pH (pHi) changes, playing important roles in both the classical BMP signaling pathway and non-BMP signaling pathways. Given that Smad5 can move intracellularly in response to changes in physicochemical properties, its cellular localization may play a crucial role in the development of respiratory diseases. This article will explore the possibility that its distribution characteristics may be an important factor that is easily overlooked and not adequately considered in disease research.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Signal Transduction",
+ "Animals",
+ "Smad5 Protein",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39570415",
+ "Title": "European journal of nutrition",
+ "ArticleTitle": "Composite dietary antioxidant index, chronic respiratory disease, and all-cause mortality: National Health and Nutrition Examination Survey, 2003-2018.",
+ "Abstract": "Our findings indicate that high CDAI is a significant protective factor against CRD and all-cause mortality in the US population.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nutrition Surveys",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Adult",
+ "Aged",
+ "Antioxidants",
+ "Adolescent",
+ "Child, Preschool",
+ "Young Adult",
+ "Aged, 80 and over",
+ "Infant",
+ "Chronic Disease",
+ "Child",
+ "Diet",
+ "United States",
+ "Respiratory Tract Diseases",
+ "Risk Factors",
+ "Mortality",
+ "Respiration Disorders"
+ ]
+ },
+ {
+ "PMID": "39570333",
+ "Title": "International journal of biometeorology",
+ "ArticleTitle": "The impact of diurnal temperature range on the risk of hospitalizations in a low-income setting: the case of the Central Coast of Vietnam.",
+ "Abstract": "The study aims to evaluate the effects of diurnal temperature range (DTR) on all causes, cardiovascular and respiratory conditions in the Central Coast of Vietnam, a tropical, low-income region with high DTR exposure but limited research. Daily hospital admission data from the largest hospitals in three provinces were analyzed alongside meteorological data. A time-series analysis using a generalized linear distributed lag model was conducted to examine the non-linear DTR-hospitalization association. A random-effect meta-analysis using restricted maximum likelihood was performed to calculate the pooled effects across three provinces. Stratified analyses by gender, age, season and natural disaster occurrence were conducted to identify vulnerable subpopulations. The multi-province pooled effects indicated that a 1\u00a0\u00b0C increase in DTR raised the risk of hospitalizations for all causes and respiratory diseases by 1.5% [1.2-1.8%] and 0.5% [0.0-1.0%], at lag 0-6 days. The effects of DTR on cardiovascular diseases, as well as those stratified by subgroups, were not statistically significant. Additionally, DTR had a greater adverse effect during the dry season and in the presence of natural disaster. Females and the elderly were slightly more susceptible to respiratory admissions, while males and younger individuals had a higher risk of all-cause admissions due to greater DTR effects. DTR was an independent risk factor for the exacerbation of all and specific causes, particularly among the susceptible subgroups. The findings suggested that it is necessary to take preventive measures to protect these at-risk populations from the adverse effects of extreme DTR exposure.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Vietnam",
+ "Humans",
+ "Hospitalization",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Temperature",
+ "Aged",
+ "Adult",
+ "Adolescent",
+ "Respiratory Tract Diseases",
+ "Young Adult",
+ "Infant",
+ "Cardiovascular Diseases",
+ "Child, Preschool",
+ "Child",
+ "Poverty",
+ "Infant, Newborn",
+ "Aged, 80 and over",
+ "Risk"
+ ]
+ },
+ {
+ "PMID": "39566943",
+ "Title": "BMJ open",
+ "ArticleTitle": "Features of causes of indirect certified disaster-related death in areas affected by the Fukushima Daiichi nuclear power plant accident: an observational study.",
+ "Abstract": "To prevent indirect disaster-related deaths in the future, it is important to consider appropriate intervention methods by age group and period since disaster occurrence. It is especially important to improve the environment of evacuation shelters and establish a healthcare system for evacuees, create a system for cancer screening and treatment during evacuation and expand long-term suicide prevention measures.",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Fukushima Nuclear Accident",
+ "Japan",
+ "Retrospective Studies",
+ "Male",
+ "Female",
+ "Aged",
+ "Middle Aged",
+ "Adult",
+ "Cause of Death",
+ "Young Adult",
+ "Adolescent",
+ "Child",
+ "Aged, 80 and over",
+ "Child, Preschool",
+ "Infant",
+ "Disasters",
+ "Earthquakes",
+ "Respiratory Tract Diseases",
+ "Cardiovascular Diseases",
+ "Suicide",
+ "Infant, Newborn",
+ "Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39566532",
+ "Title": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
+ "ArticleTitle": "[Research progress on the role of exosomes in respiratory diseases].",
+ "Abstract": "Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine. During the progression of respiratory tract diseases, exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins, disrupting the respiratory defense system and inducing or exacerbating the disease. Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases, which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections. The treatment of respiratory diseases is also closely related to exosomes. The low immunogenicity and high compatibility of exosomes make them effective tools for delivering molecules and drugs for treatment.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Exosomes",
+ "Humans",
+ "Respiratory Tract Diseases",
+ "Animals",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39550655",
+ "Title": "Recenti progressi in medicina",
+ "ArticleTitle": "[Not Available].",
+ "Abstract": "The River Sacco Basin (Rsb) is a site of National interest, characterized by several environmental pressures such as industrial facilities. This study investigates the association between long-term exposure to industrial-PM10 and -NOx and cause-specific mortality (non-accidental, cardiovascular, respiratory, and cancer) in the Rsb in the 2006-2018 period. We enrolled 301,681 residents near 14 major industrial plants (grouped into 5 30-km2 spatial domains). Residential exposure to annual PM10 and NOx was considered as categorical exposure (high (>80th percentile), medium (50th-80th), and low (<50th)). We applied adjusted domain specific Cox regression models (covariates: age, sex, and deprivation index) and performed a relative meta-analysis. We obtain a pooled 34% increase in respiratory mortality for high PM10 levels. Elevated risks were also observed for non-accidental and cancer mortality, highlighting the need for continuous monitoring and preventive interventions.",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Particulate Matter",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Cohort Studies",
+ "Environmental Exposure",
+ "Respiratory Tract Diseases",
+ "Neoplasms",
+ "Air Pollution",
+ "Air Pollutants",
+ "Cardiovascular Diseases",
+ "Italy",
+ "Rivers",
+ "Young Adult",
+ "Proportional Hazards Models",
+ "Manufacturing and Industrial Facilities",
+ "Adolescent",
+ "Cause of Death",
+ "Industry",
+ "Nitrogen Oxides",
+ "Child, Preschool",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39544058",
+ "Title": "Revue medicale suisse",
+ "ArticleTitle": "[Volatile organic compounds and respiratory diseases].",
+ "Abstract": "Our home is a place of refuge and protection, where we spend an average of 80 % of our time. Indoor air quality is an essential element that directly influences the health and well-being of individuals. The main sources of indoor pollution are human activity, which releases not only fine particles and carbon monoxide, but also volatile organic compounds (VOCs). A growing number of studies show a relationship between respiratory pathologies such as chronic obstructive pulmonary disease, asthma or Sick Building Syndrome, and exposure to VOCs. The aim of this article is to explore the relationship between VOCs and respiratory diseases, as well as the strategies to prevent their effect on health.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Volatile Organic Compounds",
+ "Air Pollution, Indoor",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Respiratory Tract Diseases",
+ "Asthma",
+ "Sick Building Syndrome"
+ ]
+ },
+ {
+ "PMID": "39543369",
+ "Title": "Molecular psychiatry",
+ "ArticleTitle": "Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis.",
+ "Abstract": "People with bipolar disorder (BD) have an increased risk of premature mortality and the respiratory mortality rate is higher than those of the general population. To date, however, the evidence on respiratory disease in this population has not been meta-analyzed. We systematically review and meta-analyze the frequency of respiratory diseases in patients with BD and to compare prevalence and odds ratio (OR) with the general population. The systematic literature search was conducted in Pubmed, PsycINFO, Scielo and Scopus, with snowball search of reference and citation lists. Inclusion criteria were studies reporting diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer and tuberculosis) in people with BD according to operationalized criteria and where possible, control group. Of the 2158 articles screened, 20 including 962,352 people with BD and 37,340,405 control group, met the inclusion criteria. In people with BD, the prevalence of COPD was 9.14% (95%CI: 6.61-12.5%), asthma 6.4% (95%CI: 4.56-8.91%), pneumonia 2.78% (95%CI: 2.51-3.08%) and lung cancer 0.44% (95%CI:0.23-0.84%). Compared to the general population, people with BD had significantly higher rates of COPD (OR: 1.73; 95% CI: 1.40-2.14), showing an increased rate in younger and female patients; asthma (OR: 1.91, 95% CI: 1.25-2.94), with a greater rate in younger patients; and pneumonia (OR: 2.82, 95% CI: 1.33-5.99). In the first meta-analysis on the topic, BD was associated with an increased risk of respiratory illness versus the general population. In COPD and asthma, young people and women are at particular risk. Prevention programs are urgently needed.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bipolar Disorder",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Asthma",
+ "Prevalence",
+ "Female",
+ "Respiratory Tract Diseases",
+ "Lung Neoplasms",
+ "Male",
+ "Pneumonia",
+ "Odds Ratio",
+ "Respiration Disorders",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39537245",
+ "Title": "European respiratory review : an official journal of the European Respiratory Society",
+ "ArticleTitle": "Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications.",
+ "Abstract": "Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30-150\u2005nm), microvesicles (sized 50-1000\u2005nm) and apoptotic bodies (sized 500-2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cell Communication",
+ "Extracellular Vesicles",
+ "Animals",
+ "Lung",
+ "Lung Diseases",
+ "Signal Transduction",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39530346",
+ "Title": "Epidemiologia e prevenzione",
+ "ArticleTitle": "[Personal protection strategies for mitigating the effects of air pollution: A narrative literature review].",
+ "Abstract": "this narrative review provides an overview of personal strategies capable of reducing air pollution exposure and consequently mitigating its negative impact on health. These findings can support the development of recommendations and communication and prevention interventions, promoting risk reduction policies and increased awareness and engagement from both healthcare and non-healthcare networks at the local level. Although more robust systematic approaches are needed, this review serves as a useful tool for stakeholders and citizens, while also providing a simple instrument with significant communicative potential, applicable on a large scale.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Cardiovascular Diseases",
+ "Respiratory Tract Diseases",
+ "Environmental Monitoring",
+ "Air Filters",
+ "Child",
+ "Exercise",
+ "Aged",
+ "Air Pollutants",
+ "Masks"
+ ]
+ },
+ {
+ "PMID": "39521464",
+ "Title": "BMJ open",
+ "ArticleTitle": "Nepal Family Cohort study: a study protocol.",
+ "Abstract": "Findings will be disseminated through traditional academic pathways, including peer-reviewed publications and conference presentations. We will also engage the study population and local media (ie, research blogs and dissemination events) and prepare research and policy briefings for stakeholders and leaders at the local, provincial and national levels.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nepal",
+ "Child",
+ "Risk Factors",
+ "Female",
+ "Research Design",
+ "Male",
+ "Longitudinal Studies",
+ "Adult",
+ "Adolescent",
+ "Parents",
+ "Child, Preschool",
+ "Air Pollution",
+ "Respiratory Tract Diseases",
+ "Cohort Studies",
+ "Life Style",
+ "Environmental Exposure"
+ ]
+ },
+ {
+ "PMID": "39515807",
+ "Title": "Allergologia et immunopathologia",
+ "ArticleTitle": "Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases.",
+ "Abstract": "Respiratory diseases in children are common health problems that significantly impact their quality of life and health status, and this has its own unique challenges compared to adults. A growing body of research has focused on epigenetic mechanisms that relate with the development of various diseases, such as pediatric respiratory diseases. Noncoding RNAs (ncRNAs), especially long noncoding RNAs, microRNA, and circular RNA, are reported to play a regulatory role in pediatric respiratory diseases whose mutations or aberrant expressions are strongly associated with the development of these diseases. In this review, we mainly discussed the functions of these three ncRNAs in pediatric respiratory diseases.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "RNA, Untranslated",
+ "RNA, Long Noncoding",
+ "Epigenesis, Genetic",
+ "MicroRNAs",
+ "Respiratory Tract Diseases",
+ "RNA, Circular"
+ ]
+ },
+ {
+ "PMID": "39513278",
+ "Title": "Journal of global health",
+ "ArticleTitle": "Dysregulated blood biomarkers in women with acute and chronic respiratory conditions due to air pollutant exposure: An exploratory systematic review.",
+ "Abstract": "PROSPERO: 42023435721.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers",
+ "Female",
+ "Air Pollutants",
+ "Respiratory Tract Diseases",
+ "Chronic Disease",
+ "Environmental Exposure",
+ "Air Pollution",
+ "Acute Disease"
+ ]
+ },
+ {
+ "PMID": "39505076",
+ "Title": "Chemosphere",
+ "ArticleTitle": "Spatial associations of daily PM",
+ "Abstract": "Air pollution, particularly fine particulate matter less than 2.5\u00a0\u03bcm in diameter (PM",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Particulate Matter",
+ "Republic of Korea",
+ "Cardiovascular Diseases",
+ "Humans",
+ "Air Pollutants",
+ "Air Pollution",
+ "Hospitalization",
+ "Environmental Exposure",
+ "Respiratory Tract Diseases",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39503908",
+ "Title": "International archives of occupational and environmental health",
+ "ArticleTitle": "Impact of extreme bushfire seasons on rates of occupational injury and disease compensation claims in first responders.",
+ "Abstract": "Extreme bushfire events were associated with increased mental claims rates in all FR, with the highest in firefighters. Strategies to better prevent and manage injury/disease risk in FR are urgently required, particularly for mental health conditions.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Adult",
+ "Occupational Injuries",
+ "Workers' Compensation",
+ "Seasons",
+ "Middle Aged",
+ "Occupational Diseases",
+ "Emergency Responders",
+ "Mental Disorders",
+ "Firefighters",
+ "Victoria",
+ "Musculoskeletal Diseases",
+ "Wildfires",
+ "Respiratory Tract Diseases",
+ "Young Adult",
+ "Police"
+ ]
+ },
+ {
+ "PMID": "39502059",
+ "Title": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
+ "ArticleTitle": "[Research Progress of Breath Sound Analysis for Common Respiratory Diseases in Children].",
+ "Abstract": "Breath sounds can reflect the physiological and pathological conditions of the lungs and airways.Due to the differences in acoustic characteristics of breath sounds between healthy children and those with different respiratory diseases,analyzing breath sounds may provide important information for the diagnosis and treatment of respiratory diseases in children.With the development of digital auscultation,children's breath sounds have gradully become a research focus.This article summarizes the recent research progress in breath sound analysis for the diagnosis and treatment of common respiratory diseases in children,offering reference for the research in related fields.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "Respiratory Sounds",
+ "Respiratory Tract Diseases",
+ "Auscultation"
+ ]
+ },
+ {
+ "PMID": "39494780",
+ "Title": "The British journal of nutrition",
+ "ArticleTitle": "Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?",
+ "Abstract": "The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother\u2013child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5\u00b75 years were considered jointly through five allergic and respiratory multimorbidity clusters (\u2018asymptomatic\u2019 - reference, \u2018early wheeze without asthma\u2019, \u2018asthma only\u2019, \u2018allergies without asthma\u2019 and \u2018multi-allergic\u2019). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the \u2018early wheeze without asthma\u2019 cluster (aOR (95 % CI) = 0\u00b795 (0\u00b790, 0\u00b799) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the \u2018asthma only\u2019 cluster (aOR (95 % CI) = 1\u00b709 (1\u00b700, 1\u00b719) per sd). No association was found with the \u2018allergies without asthma\u2019 or \u2018multi-allergic\u2019 clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5\u00b75 years, though the associations were weak.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Pregnancy",
+ "Antioxidants",
+ "Diet",
+ "Hypersensitivity",
+ "Child, Preschool",
+ "Inflammation",
+ "Male",
+ "Birth Cohort",
+ "Multimorbidity",
+ "Adult",
+ "Maternal Nutritional Physiological Phenomena",
+ "Infant",
+ "Respiratory Tract Diseases",
+ "Asthma",
+ "Prenatal Exposure Delayed Effects",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39494537",
+ "Title": "Current opinion in supportive and palliative care",
+ "ArticleTitle": "Education for people with serious chronic respiratory diseases and their informal caregivers: how to address challenges that impact learning.",
+ "Abstract": "Learner-centered education may enhance knowledge acquisition in people with serious chronic respiratory diseases and their informal caregivers aiming to gain control over symptoms and optimize shared decision making and advance care planning.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Caregivers",
+ "Chronic Disease",
+ "Patient Education as Topic",
+ "Health Literacy",
+ "Palliative Care",
+ "Advance Care Planning",
+ "Decision Making, Shared",
+ "Learning",
+ "Respiratory Tract Diseases",
+ "Health Knowledge, Attitudes, Practice",
+ "Adaptation, Psychological",
+ "Decision Making"
+ ]
+ },
+ {
+ "PMID": "39494092",
+ "Title": "International journal of public health",
+ "ArticleTitle": "Long-Term Exposure to Nitrogen Dioxide and Ozone and Mortality: Update of the WHO Air Quality Guidelines Systematic Review and Meta-Analysis.",
+ "Abstract": "An increasing body of evidence, with new results from countrywide areas and the Western Pacific, supports certainty, including new outcomes.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Air Pollutants",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Europe",
+ "Nitrogen Dioxide",
+ "Ozone",
+ "Respiratory Tract Diseases",
+ "World Health Organization"
+ ]
+ },
+ {
+ "PMID": "39493756",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Idbview: a database and interactive platform for respiratory-associated disease.",
+ "Abstract": "Public databases have become invaluable resources for disease research, particularly in the realm of identifying and validating biomarkers, thus playing a significant role in enhancing our understanding of respiratory diseases. To facilitate this understanding, the development of user-friendly analytical tools and advanced systematic models that leverage the growing omics data and clinical information datasets is essential. Despite the importance of such resources, the research progress related to respiratory diseases is hindered by the absence of a centralized platform housing easily accessible datasets and accompanying visualization tools. In an effort to streamline and standardize information sharing across diverse respiratory research initiatives, we introduce Idbview, a specialized digital database focusing on respiratory conditions, offering interactive visualization functionalities powered by both Vue and R Shiny applications. Idbview brings together clinical data and various omics datasets, serving as a centralized repository, while also providing users with a suite of interactive tools to analyze and visualize data from multiple perspectives. As a comprehensive resource hub, Idbview aims to support the research community in conducting further studies in both clinical and bioinformatics domains, with the website accessible at https://idbview.com.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Computational Biology",
+ "User-Computer Interface",
+ "Databases, Factual",
+ "Respiratory Tract Diseases",
+ "Software"
+ ]
+ },
+ {
+ "PMID": "39489274",
+ "Title": "Environmental research",
+ "ArticleTitle": "Associations between various types of mortality and temperature variability distinguishing the intraday and interday effects in South Korea.",
+ "Abstract": "This study provided evidence on the season-stratified, independent impacts of intraday and interday temperature variabilities on total, age-specific, gender-specific, and cause-specific mortality risks in South Korea drawing attention to the need of targeted policies to alleviate the impacts on human health.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Republic of Korea",
+ "Humans",
+ "Female",
+ "Male",
+ "Temperature",
+ "Middle Aged",
+ "Seasons",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Mortality",
+ "Adult",
+ "Child",
+ "Adolescent",
+ "Child, Preschool",
+ "Young Adult",
+ "Infant",
+ "Aged, 80 and over",
+ "Respiratory Tract Diseases",
+ "Infant, Newborn"
+ ]
+ },
+ {
+ "PMID": "39477760",
+ "Title": "Medicina clinica",
+ "ArticleTitle": "Trends in mortality in Spain, with a special focus on respiratory-related conditions in the midst of the COVID-19 pandemic.",
+ "Abstract": "Despite overall mortality returning to pre-pandemic levels, this study highlights a significant increase in respiratory disease deaths in Spain in 2022 compared to 2019.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Spain",
+ "COVID-19",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Adolescent",
+ "Young Adult",
+ "Cause of Death",
+ "Aged, 80 and over",
+ "Child",
+ "Child, Preschool",
+ "Infant",
+ "Respiratory Tract Diseases",
+ "Mortality",
+ "Pandemics",
+ "Infant, Newborn"
+ ]
+ },
+ {
+ "PMID": "39472952",
+ "Title": "Health and quality of life outcomes",
+ "ArticleTitle": "An item bank to measure health-related quality of life among young children (0-5-years-old) affected by respiratory illnesses - expert stakeholders and end-users from the Western Cape, South Africa.",
+ "Abstract": "An item bank was developed as a first step to develop a comprehensive disease-specific HRQoL tool for young children with respiratory illnesses in an LMIC. Input from caregivers and content experts was crucial in creating two HRQoL item banks tailored to the developmental differences between 0 and 2 and 3-5-year age groups. Their contributions ensured the tool effectively captures age-appropriate aspects of HRQoL. Future studies should focus on assessing the validity and reliability of these item banks.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "South Africa",
+ "Quality of Life",
+ "Child, Preschool",
+ "Infant",
+ "Male",
+ "Female",
+ "Delphi Technique",
+ "Surveys and Questionnaires",
+ "Respiratory Tract Diseases",
+ "Infant, Newborn",
+ "Psychometrics",
+ "Respiratory Tract Infections"
+ ]
+ },
+ {
+ "PMID": "39468133",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Gastrointestinal and respiratory morbidity when introducing eggs as complementary food: a randomised controlled trial in South African infants.",
+ "Abstract": "We investigated the incidence and duration of morbidity symptoms among infants aged 6 to 9 months from a low socioeconomic community receiving one egg daily for 6 months. This was a secondary outcome of a randomised controlled trial (RCT) of 500 infants conducted in Jouberton, South Africa. The primary outcome was linear growth. Morbidity data were collected weekly using a symptoms diary and qualitative data with focus group discussions at the endpoint. Ethical approval was obtained from the North-West University Health Research Ethics Committee. The intervention group had a\u2009~\u20095% higher incidence of gastrointestinal morbidity (17.0%) compared to the control group (11.9%). Gastrointestinal morbidity without fever tended to be 1.4 times higher in the intervention group (OR: 1.43, 95% CI: 1.03, 1.93; P\u2009=\u20090.058) and tended to be 4 times higher with fever (OR: 4.07, 95% CI: 0.86, 19.23; P\u2009=\u20090.077). The duration of total gastrointestinal and respiratory morbidity was 1.5 days longer in the intervention group (\u03b2: 1.491; 95% CI 0.064, 2.918; P\u2009=\u20090.041). Complementary feeding with eggs may have contributed towards an increased risk for gastrointestinal morbidity.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Infant",
+ "South Africa",
+ "Female",
+ "Male",
+ "Eggs",
+ "Gastrointestinal Diseases",
+ "Infant Nutritional Physiological Phenomena",
+ "Respiratory Tract Diseases",
+ "Incidence",
+ "Morbidity"
+ ]
+ },
+ {
+ "PMID": "39466470",
+ "Title": "Current allergy and asthma reports",
+ "ArticleTitle": "Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases.",
+ "Abstract": "BMP2 signaling pathway includes the canonical and non-canonical signaling pathway. The canonical signaling pathway is the BMP2-SMAD pathway, and the non-canonical signaling pathway includes mitogen-activated protein kinase (MAPK) pathway and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway. The BMP2 is related to pulmonary hypertension (PH), lung cancer, pulmonary fibrosis (PF), asthma, and chronic obstructive pulmonary disease (COPD). BMP2 inhibits the proliferation of pulmonary artery smooth muscle cells (PASMCs), promotes the apoptosis of PASMCs to reduce pulmonary vascular remodeling in PH, which is closely related to the canonical and non-canonical pathway. In addition, BMP2 stimulates the proliferation and migration of cells to promote the occurrence, colonization, and metastasis of lung cancer through the canonical and the non-canonical pathway. Meanwhile, BMP2 exert anti-fibrotic function in PF through canonical signaling pathway. Moreover, BMP2 inhibits airway inflammation to maintain airway homeostasis in asthma. However, the signaling pathways involved in asthma are poorly understood. BMP2 inhibits the expression of ciliary protein and promotes squamous metaplasia of airway epithelial cells to accelerate the development of COPD. In conclusion, BMP2 may be a therapeutic target for several respiratory diseases.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bone Morphogenetic Protein 2",
+ "Signal Transduction",
+ "Animals",
+ "Respiratory Tract Diseases",
+ "Lung Neoplasms",
+ "Hypertension, Pulmonary"
+ ]
+ },
+ {
+ "PMID": "39465586",
+ "Title": "COPD",
+ "ArticleTitle": "Comorbidity Patterns in Chronic Obstructive Pulmonary Disease and Their Associations with Service Utilization.",
+ "Abstract": "Common combinations of comorbidities among inpatients with COPD were identified from an extensive collection of discharge medical records. Furthermore, the associations between comorbidities, inpatient service usage, and readmission rates were determined.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Male",
+ "Female",
+ "Aged",
+ "Comorbidity",
+ "Patient Readmission",
+ "Length of Stay",
+ "Middle Aged",
+ "Retrospective Studies",
+ "Heart Failure",
+ "Prospective Studies",
+ "Hypertension",
+ "Myocardial Ischemia",
+ "Pulmonary Heart Disease",
+ "Aged, 80 and over",
+ "Prevalence",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39462582",
+ "Title": "Environmental health and preventive medicine",
+ "ArticleTitle": "The effect modification of PM",
+ "Abstract": "PM",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Ozone",
+ "Japan",
+ "Particulate Matter",
+ "Humans",
+ "Air Pollutants",
+ "Cities",
+ "Aged",
+ "Female",
+ "Mortality",
+ "Male",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Adult",
+ "Air Pollution",
+ "Hot Temperature",
+ "Temperature",
+ "Respiratory Tract Diseases",
+ "Environmental Exposure",
+ "Young Adult",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39462039",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Genetic evidence of bidirectional mendelian randomization study on the causality between gut microbiome and respiratory diseases contributes to gut-lung axis.",
+ "Abstract": "Observational studies and clinical trials have suggested the relationship between the gut microbiome and respiratory diseases, but the causality between them remains unclear. Firstly, we selected eight respiratory diseases Genome-wide association study (GWAS) datasets mainly from the FinnGen collaboration as outcomes. The exposure was based on GWAS statistics about the gut microbiome, sourced from the MiBioGen consortium, including gut microbial taxa. The causal link between the gut microbiome and respiratory illnesses was then estimated using a Two-sample Mendelian randomization (MR) analysis, including the inverse-variance weighted (IVW), weighted median, MR-Egger, simple mode, and weighted mode. To ensure reliability, F-statistics and sensitivity tests were conducted. Furthermore, we performed a reverse MR analysis of the pre-Mendelian positive findings to possible reverse causality. For the 196 gut microbe taxa, the IVW analysis suggested 88 potential associations with eight clinically prevalent respiratory diseases. Among them, 30 causal associations were found in more than one MR method. Multiple statistical corrections have confirmed three causal associations: genus Holdemanella was a risk factor for chronic obstructive pulmonary disease (COPD) (P\u2009=\u20091.3\u2009\u00d7\u200910",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Gastrointestinal Microbiome",
+ "Genome-Wide Association Study",
+ "Lung",
+ "Respiratory Tract Diseases",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39457304",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Respiratory Symptoms and Paper Dust Exposure among Workers in the Paper Industry in Ethiopia: A Comparative Cross-Sectional Study.",
+ "Abstract": "Chronic respiratory symptoms are a health concern in the paper industry. This study evaluates the association between personal inhalable paper dust exposure and chronic respiratory symptoms among workers in this industry. In total, 270 workers from the paper industry and 267 from a water bottling factory participated. Chronic respiratory symptoms were assessed using a standardized questionnaire, modified from the American Thoracic Society. A job exposure matrix, based on cross-sectional personal measurements of inhalable paper dust, was used to estimate the exposure-response relationship between cumulative dust exposure and chronic respiratory symptoms. There was a higher prevalence of chronic coughs (27.4% vs. 7.5%), breathlessness (25.6% vs. 11%), coughs with sputum (21.1% vs. 1.1%), and wheezing (25.6% vs. 5%) among paper workers compared to those in the water bottling industry. A Poisson regression analysis revealed that the prevalence ratios for chronic coughs (APR = 3.3 and 95% CI: 2.0-5.4), breathlessness (APR = 2.2 and 95% CI: 1.4-3.4), and wheezing (APR = 4.3 and 95% CI: 2.3-7.7) were significantly higher in paper workers than in water bottling workers. Among paper workers, a significant exposure-response relationship was observed between cumulative dust exposure and chronic coughs after adjusting for age, sex, history of respiratory illnesses, work in other dusty industries, and use of biofuels. As there were only four ever-smokers, smoking was not included in the regression analysis. The results show a significant association between dust exposure and coughing, highlighting the need for control measures to prevent the development of respiratory symptoms among workers.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cross-Sectional Studies",
+ "Dust",
+ "Adult",
+ "Male",
+ "Occupational Exposure",
+ "Ethiopia",
+ "Female",
+ "Paper",
+ "Middle Aged",
+ "Cough",
+ "Prevalence",
+ "Young Adult",
+ "Respiratory Tract Diseases",
+ "Respiratory Sounds",
+ "Surveys and Questionnaires",
+ "Occupational Diseases",
+ "Industry",
+ "Dyspnea",
+ "Air Pollutants, Occupational"
+ ]
+ },
+ {
+ "PMID": "39453518",
+ "Title": "International journal of biometeorology",
+ "ArticleTitle": "The interactive effect of extreme weather events and PM",
+ "Abstract": "With climate change posing increasing threats and aging populations, understanding the complex relationship between extreme temperatures, PM",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Particulate Matter",
+ "Aged",
+ "Female",
+ "Male",
+ "Cross-Over Studies",
+ "Altitude",
+ "Air Pollutants",
+ "Respiratory Tract Diseases",
+ "China",
+ "Extreme Weather",
+ "Aged, 80 and over",
+ "Middle Aged",
+ "Cities",
+ "Air Pollution"
+ ]
+ },
+ {
+ "PMID": "39444957",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Impacts from air pollution on respiratory disease outcomes: a meta-analysis.",
+ "Abstract": "Our study supports associations between air pollutants, including non-exhaust trace metals, and respiratory outcomes across different age groups. The findings underscore the need for stringent environmental health policies and further research, especially in regions with higher pollution levels. The future studies should consider long-term and short-term exposures separately and include diverse populations to improve the accuracy and generalizability of the results.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Adult",
+ "Child",
+ "Humans",
+ "Air Pollutants",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Particulate Matter",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39444118",
+ "Title": "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi",
+ "ArticleTitle": "[Association of solid fuel use for heating and smoking with respiratory diseases: a prospective cohort study].",
+ "Abstract": {
+ "b": "Conclusions:",
+ "i": "CI"
+ },
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Heating",
+ "Prospective Studies",
+ "Female",
+ "Male",
+ "Respiratory Tract Diseases",
+ "Proportional Hazards Models",
+ "China",
+ "Smoking",
+ "Risk Factors",
+ "Adult",
+ "Air Pollution, Indoor"
+ ]
+ },
+ {
+ "PMID": "39443904",
+ "Title": "Environmental health : a global access science source",
+ "ArticleTitle": "A co-created citizen science project on the short term effects of outdoor residential woodsmoke on the respiratory health of adults in the Netherlands.",
+ "Abstract": "Adults experienced more SOB during rest, nasal symptoms and used more medication to treat respiratory symptoms on days with higher levels of outdoor woodsmoke concentrations.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Netherlands",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Smoke",
+ "Wood",
+ "Air Pollutants",
+ "Environmental Exposure",
+ "Aged",
+ "Particulate Matter",
+ "Respiratory Tract Diseases",
+ "Glucose"
+ ]
+ },
+ {
+ "PMID": "39439241",
+ "Title": "Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen",
+ "ArticleTitle": "Breathing time: a longue-dur\u00e9e multidisciplinary study of respiratory illnesses and airborne diseases in Switzerland (16",
+ "Abstract": "This research is the first of its kind to assess of the impact of respiratory illnesses and airborne diseases (acronymized as \"RIAD\" hereafter) on Swiss mortality in the long run, between the 16",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Switzerland",
+ "Humans",
+ "History, 20th Century",
+ "History, 21st Century",
+ "History, 17th Century",
+ "History, 16th Century",
+ "Respiratory Tract Diseases",
+ "Male",
+ "Female",
+ "History, 18th Century",
+ "History, 19th Century",
+ "Adult",
+ "Middle Aged",
+ "Respiration Disorders",
+ "Aged",
+ "Child",
+ "Adolescent",
+ "Air Pollution"
+ ]
+ },
+ {
+ "PMID": "39436432",
+ "Title": "International archives of occupational and environmental health",
+ "ArticleTitle": "Air quality disparities and respiratory health risks in critically polluted and relatively non-polluted areas: a prospective child health study.",
+ "Abstract": "This research underscores the pressing need to address air pollution in critically polluted areas and its profound effects on children's respiratory health. Public health interventions, such as reducing emissions from industries and creating green spaces, should be prioritized. Furthermore, early respiratory health screening in schools within polluted areas could aid in the timely diagnosis and management of respiratory issues in children.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Prospective Studies",
+ "Child",
+ "Respiratory Tract Diseases",
+ "Male",
+ "Female",
+ "Air Pollutants",
+ "Particulate Matter",
+ "Air Pollution",
+ "Child Health",
+ "Environmental Exposure",
+ "Air Pollution, Indoor",
+ "Adolescent",
+ "Environmental Monitoring"
+ ]
+ },
+ {
+ "PMID": "39435892",
+ "Title": "Epidemiology (Cambridge, Mass.)",
+ "ArticleTitle": "Long-term Associations Between Time-varying Exposure to Ambient PM 2.5 and Mortality: An Analysis of the UK Biobank.",
+ "Abstract": "We found associations of long-term PM 2.5 exposure with all-cause, nonaccidental, respiratory, and lung cancer mortality, but not with cardiovascular mortality. This study benefits from finely reconstructed time-varying exposures and extensive control for confounding, further supporting a plausible causal link between long-term PM 2.5 and mortality.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "United Kingdom",
+ "Particulate Matter",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Proportional Hazards Models",
+ "Environmental Exposure",
+ "Cardiovascular Diseases",
+ "Biological Specimen Banks",
+ "Mortality",
+ "Time Factors",
+ "Air Pollution",
+ "Air Pollutants",
+ "Adult",
+ "Cohort Studies",
+ "Machine Learning",
+ "Respiratory Tract Diseases",
+ "UK Biobank"
+ ]
+ },
+ {
+ "PMID": "39434079",
+ "Title": "BMC public health",
+ "ArticleTitle": "The construction and validity assessment of the respiratory air quality health index (AQHI) based on the analytic hierarchy process in Tianjin, China.",
+ "Abstract": "This study indicated that compared with AQI, the constructed AQHI based on AHP may predict the health risk of air pollution more effectively. AHP may become a new method to construct AQHI which needs to be proved by taking into consideration by more studies.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Air Pollution",
+ "Respiratory Tract Diseases",
+ "Risk Assessment",
+ "Air Pollutants",
+ "Reproducibility of Results"
+ ]
+ },
+ {
+ "PMID": "39424664",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Assessing the impact of meteorological factors and air pollution on respiratory disease mortality rates: a random forest model analysis (2017-2021).",
+ "Abstract": "Air pollution poses a significant threat to the health of all living beings on our planet. It has been scientifically established as a crucial factor affecting mortality rates, respiratory illnesses, mental well-being, and overall health. This study aimed to investigate the impact of air pollution and meteorological factors on respiratory disease mortality rates in Mashhad in 2017-2021 using a Random Forest (RF) model. At first, the daily statistics of meteorological parameters (pressure, humidity, temperature, solar radiation) during 2017-2021 were collected. The information related to pollutants pollutants such as PM",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Air Pollution",
+ "Particulate Matter",
+ "Air Pollutants",
+ "Meteorological Concepts",
+ "Respiratory Tract Diseases",
+ "Iran",
+ "Sulfur Dioxide",
+ "Nitrogen Dioxide",
+ "Random Forest"
+ ]
+ },
+ {
+ "PMID": "39424373",
+ "Title": "BMJ open quality",
+ "ArticleTitle": "Implementation of a standardised questionnaire for documenting preoperative respiratory illness in paediatric patients.",
+ "Abstract": "Paediatric patients often present with symptoms of respiratory illnesses in the weeks leading up to surgery. Current or recent illness can increase the risk of experiencing perioperative respiratory complications. Ideally, children with recent illnesses should be identified before coming to the hospital to determine the safest course of action. We recognised that our system lacked a standardised process for documenting preoperative respiratory illness during the preoperative phone call. The global aim of this quality improvement initiative was to decrease paediatric perioperative respiratory adverse events. The SMART Aim (Specific, Measurable, Achievable, Relevant and Time-bound) was to increase the percentage of patients with standardised documentation of preoperative respiratory illness from 0% to 90% by 1 March 2023. Implementation of a standardised preoperative illness questionnaire increased standardised illness documentation from 0% to 95%. Nurses quickly adopted this intervention and easily integrated it into their routine workflow. Clinical leaders elected to implement the intervention electronically across all three operating room (OR) locations (main OR, satellite location and procedure centre). Future implementation of additional standardised preoperative processes will be needed to improve the global aim of decreasing perioperative respiratory complications.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Surveys and Questionnaires",
+ "Child",
+ "Quality Improvement",
+ "Documentation",
+ "Preoperative Care",
+ "Pediatrics",
+ "Respiration Disorders",
+ "Respiratory Tract Diseases",
+ "Preoperative Period"
+ ]
+ },
+ {
+ "PMID": "39423508",
+ "Title": "Ecotoxicology and environmental safety",
+ "ArticleTitle": "Non-dietary exposure to phthalates in primary school children: Risk and correlation with anthropometric indices, cardiovascular and respiratory diseases.",
+ "Abstract": "Phthalates are endocrine disruptors of increasing concern for human health; however, previous studies have only assessed the association between internal exposure and human health. We aimed to assess the non-carcinogenic and carcinogenic risks of non-dietary exposure to phthalates in indoor environments among primary school children and their correlations with health indicators. A study involving 54 children was conducted in Jinan, Shandong Province, China. Questionnaires and health examinations were conducted, dust in hard-to-clean corners of students' classrooms and homes was collected, and airborne phthalates in the middle of classrooms and family living rooms were sampled. The gas-phase phthalate concentrations, individual exposure, and non-carcinogenic and carcinogenic risks were calculated. Associations were estimated using linear mixed models. The findings revealed that phthalates posed a non-carcinogenic risk to 7.4\u202f% of the children and a moderate carcinogenic risk to 27.8\u202f% of the children, with higher non-carcinogenic and carcinogenic risks to girls than to boys. Five phthalates were negatively correlated with body mass index, dimethyl phthalate and diethyl phthalate (DEP) were significantly correlated with waist circumference, and di-iso-butyl phthalate (DiBP) was negatively correlated with hip circumference. DiBP, di-n-butyl phthalate, and DEP, were significantly correlated with cardiovascular disease, DEP and di (2-n-butoxyethyl) phthalate were correlated with decreased lung function, and di-n-octyl phthalate influenced airway inflammation. The findings indicated that phthalate exposure may negatively impact children's health, thereby warranting further comprehensive research on the health effects of these chemicals.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Phthalic Acids",
+ "Male",
+ "Female",
+ "Child",
+ "China",
+ "Cardiovascular Diseases",
+ "Air Pollution, Indoor",
+ "Environmental Exposure",
+ "Respiratory Tract Diseases",
+ "Anthropometry",
+ "Dust",
+ "Schools",
+ "Endocrine Disruptors",
+ "Risk Assessment",
+ "Body Mass Index"
+ ]
+ },
+ {
+ "PMID": "39421822",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Daily diurnal temperature range associated with emergency ambulance calls: a nine-year time-series study.",
+ "Abstract": "DTR might increase the risk of daily all-cause, cardiovascular-related, and respiratory-related EACs in Guangzhou, China. The associations were particularly strong among older adults, males, and during the warm season. Implementing public health policies is essential to mitigate the adverse health effects of DTR.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Ambulances",
+ "China",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Temperature",
+ "Aged",
+ "Adult",
+ "Emergency Medical Services",
+ "Respiratory Tract Diseases",
+ "Seasons"
+ ]
+ },
+ {
+ "PMID": "39419650",
+ "Title": "Allergology international : official journal of the Japanese Society of Allergology",
+ "ArticleTitle": "Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody.",
+ "Abstract": "Characteristic symptoms of NSAID-exacerbated respiratory disease (N-ERD) include asthma, chronic eosinophilic rhinosinusitis with nasal polyposis, cysteinyl LT (CysLT) overproduction and NSAIDs hypersensitivity. Some N-ERD patients present with episodic treatment-resistant extra-respiratory symptoms (CysLT-associated coronary artery vasospasm, gastroenteritis, or skin rash). Even when using standard treatments for respiratory and extra-respiratory symptoms, including systemic corticosteroids and aspirin desensitization, it is difficult to control the clinical symptoms and severe type 2 inflammation involved with mast cells, eosinophils, ILC2s, and platelet activation. Few treatment options are applicable in a clinical setting. Therefore, identifying effective treatments is essential for managing N-ERD patients who suffer from these conditions. Our previous observational study demonstrated 12-month omalizumab treatment of N-ERD was clinically effective against respiratory symptoms. Despite the remaining eosinophilia, omalizumab significantly reduced urinary LTE",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Omalizumab",
+ "Anti-Inflammatory Agents, Non-Steroidal",
+ "Antibodies, Anti-Idiotypic",
+ "Asthma, Aspirin-Induced",
+ "Anti-Allergic Agents",
+ "Drug Hypersensitivity",
+ "Respiratory Tract Diseases",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39419227",
+ "Title": "The Science of the total environment",
+ "ArticleTitle": "Neighborhood plant community, airborne microbiota transferred indoors and prevalence of respiratory diseases are interrelated: A cross-sectional study.",
+ "Abstract": "Airborne microbiota transferred indoors (AMTI) is linked to human respiratory health. Yet, the factors influencing these microorganisms and their connections to the prevalence of respiratory diseases (RDs) remain unclear. In this study, we examined plant communities and AMTI using VenTube, next-generation sequencing and quantitative polymerase chain reaction (qPCR) in 72 Shanghai neighborhoods in warm and cold seasons, respectively. To determine the prevalence of RDs, we collected 1026 questionnaires, enlisting 30\u00a0\u00b1\u00a05 volunteers aged 40-80, residing in the area for more than a decade, with an equal gender balance. Our results demonstrated that the AMTI communities were less diverse in the cold season than in the warm season, which is in agreement with the changes of garden plant diversity between seasons. Along the reduction of AMTI diversity, greater relative abundances of RDs-associated microbes (e.g., Pseudomonas and Streptococcus) was transferred indoors during the cold season. The questionnaire survey showed that the most prevalent symptom was shortness of breath (25.6\u00a0%), followed by rhinitis (20.8\u00a0%) and wheeze (14.4\u00a0%), with generally no prevalence difference between urban and peri-urban neighborhoods. Notably, despite the sparse garden plant community in the cold season, the abundance of Oleaceae trees showed an inverse relationship with the RDs-associated microbes as well as the prevalences of RDs based on the structural equation model results. This finding was largely supported by the negative effect of Oleaceae trees on the population of Streptococcus anginosus (qPCR) which was a dominant species transferred indoors in the cold season, given that S. anginosus is highly associated with rhinitis and rhinoconjunctivitis. Taken together, our findings suggest a strong association between the Oleaceae trees, the AMTI and the prevalence of RDs, which can shed some lights in the ecological development towards respiratory safe environment in cities.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Microbiota",
+ "Air Microbiology",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "China",
+ "Prevalence",
+ "Adult",
+ "Female",
+ "Aged",
+ "Air Pollution, Indoor",
+ "Respiratory Tract Diseases",
+ "Male",
+ "Plants",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39410863",
+ "Title": "Current opinion in pulmonary medicine",
+ "ArticleTitle": "Household air pollution and respiratory health in Africa: persistent risk and unchanged health burdens.",
+ "Abstract": "Respiratory infections, particularly in children, and other chronic respiratory diseases, are strongly attributable to household air pollution. Elimination of such exposures through interventions such as cleaner fuels and preferably, electricity, is critical to improving respiratory health on the continent.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Africa",
+ "Air Pollution, Indoor",
+ "Environmental Exposure",
+ "Respiratory Tract Infections",
+ "Respiratory Tract Diseases",
+ "Female",
+ "Risk Factors",
+ "Family Characteristics",
+ "Child",
+ "Male"
+ ]
+ },
+ {
+ "PMID": "39408565",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Update on the Role of \u03b22AR and TRPV1 in Respiratory Diseases.",
+ "Abstract": "Respiratory diseases (RDs) constitute a common public health problem both in industrialized and developing countries. The comprehension of the pathophysiological mechanisms underlying these conditions and the development of new therapeutic strategies are critical for improving the quality of life of affected patients. \u03b22-adrenergic receptor (\u03b22AR) and transient receptor potential vanilloid 1 (TRPV1) are both involved in physiological responses in the airways. \u03b22AR is implicated in bronchodilation, mucociliary clearance, and anti-inflammatory effects, while TRPV1 is involved in the mediation of pain and cough reflexes. In RDs, such as respiratory infections, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, the concentration and expression of these receptors can be altered, leading to significant consequences. In this review, we provided an update on the literature about the role of \u03b22AR and TRPV1 in these conditions. We reported how the diminished or defective expression of \u03b22AR during viral infections or prolonged therapy with \u03b22-agonists can increase the severity of these pathologies and impact the prognosis. Conversely, the role of TRPV1 was pivotal in neuroinflammation, and its modulation could lead to innovative treatment strategies in specific patients. We indicate future perspectives and potential personalized treatments in RDs through a comprehensive analysis of the roles of these receptors in the physiological and pathological mechanisms of these pathologies.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "TRPV Cation Channels",
+ "Receptors, Adrenergic, beta-2",
+ "Animals",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39406209",
+ "Title": "The American journal of tropical medicine and hygiene",
+ "ArticleTitle": "Case Report: Effects of Environmental Smoke Exposure on Respiratory Conditions-A Report of an Aboriginal Man Fire Hunting for Mud Turtles in the Top End, Northern Territory of Australia.",
+ "Abstract": "Environmental smoke has been shown to have significant associations with both causation and exacerbation of respiratory conditions. Aboriginal Australians in the Northern Territory (NT) of Australia are disproportionately affected by respiratory illness in comparison with non-Aboriginal Australians. Traditionally, Aboriginal communities have utilized fire for multiple purposes, such as land management practices, cultural ceremonies, hunting, and cooking. In this report, we describe an Aboriginal man who presented with acute exacerbation of airway disease after environmental smoke exposure while being in the close vicinity of \"fire hunting\" for \"mud turtles\" from a Top End remote Aboriginal community in the NT of Australia. This report highlights the potential impact of nontobacco environmental smoke exposure contributing to the causation and exacerbation of chronic respiratory conditions among Aboriginal Australians. Hence, further research is warranted to address mitigating strategies in this population.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Northern Territory",
+ "Animals",
+ "Smoke",
+ "Turtles",
+ "Environmental Exposure",
+ "Adult",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39395132",
+ "Title": "Aging clinical and experimental research",
+ "ArticleTitle": "Exploring the relationship between sarcopenia and 11 respiratory diseases: a comprehensive mendelian randomization analysis.",
+ "Abstract": "This data-driven MR analysis revealed SP was bidirectional causally associated with lung diseases, providing genetic evidence for further mechanistic and clinical studies to understand the crosstalk between SP and lung diseases.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Sarcopenia",
+ "Genome-Wide Association Study",
+ "Body Mass Index",
+ "Respiratory Tract Diseases",
+ "Male",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Female",
+ "Smoking",
+ "Pneumoconiosis"
+ ]
+ },
+ {
+ "PMID": "39394579",
+ "Title": "BMC public health",
+ "ArticleTitle": "Association between use of heated tobacco products and long-term respiratory effects considering smoking history: internet-based cross-sectional study in Japan.",
+ "Abstract": "These results suggest that smoking history before HTP using affects the occurrence of outcomes, and underscore the importance of considering smoking history when assessing the health effect of HTP use. Since the duration of HTP use is considerably shorter than that of cigarette use at present, further research, such as follow-up surveys assessing the long-term respiratory effects of HTP use, will be necessary.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Japan",
+ "Cross-Sectional Studies",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Tobacco Products",
+ "Surveys and Questionnaires",
+ "Internet",
+ "Smoking",
+ "Hot Temperature",
+ "Aged",
+ "Young Adult",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39391315",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "Liquid-liquid phase separation: a new perspective on respiratory diseases.",
+ "Abstract": "Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Animals",
+ "Respiratory Tract Diseases",
+ "Liquid-Liquid Extraction",
+ "Signal Transduction",
+ "Phase Separation"
+ ]
+ },
+ {
+ "PMID": "39389134",
+ "Title": "The Science of the total environment",
+ "ArticleTitle": "Risk assessment of PM",
+ "Abstract": "Air pollution mainly comes from fossil energy consumption (FEC), and it brings great threat to public health. The respiratory system of the elderly is highly susceptible to the effects of air pollution due to the decline in body functions. PM",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Particulate Matter",
+ "Aged",
+ "Humans",
+ "Air Pollutants",
+ "Risk Assessment",
+ "China",
+ "Air Pollution",
+ "Environmental Exposure",
+ "Fossil Fuels",
+ "Aged, 80 and over",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39384295",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Rainfall events and daily mortality across 645 global locations: two stage time series analysis.",
+ "Abstract": "Daily rainfall intensity is associated with varying health effects, with extreme events linked to an increasing relative risk for all cause, cardiovascular, and respiratory mortality. The observed associations varied with local climate and urban infrastructure.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Rain",
+ "Cardiovascular Diseases",
+ "Respiratory Tract Diseases",
+ "Global Health",
+ "Cause of Death",
+ "Mortality",
+ "Time Factors"
+ ]
+ },
+ {
+ "PMID": "39384238",
+ "Title": "BMJ open",
+ "ArticleTitle": "Objectively measured daily steps and health outcomes: an umbrella review of the systematic review and meta-analysis of observational studies.",
+ "Abstract": "CRD42022347055.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Observational Studies as Topic",
+ "Respiratory Tract Diseases",
+ "Systematic Reviews as Topic",
+ "Walking"
+ ]
+ },
+ {
+ "PMID": "39374569",
+ "Title": "Biosensors & bioelectronics",
+ "ArticleTitle": "Recent advances in biosensors detecting biomarkers from exhaled breath and saliva for respiratory disease diagnosis.",
+ "Abstract": "The global demand for rapid and non-invasive diagnostic methods for respiratory diseases has significantly intensified due to the wide spread of respiratory infectious diseases. Recent advancements in respiratory disease diagnosis through the analysis of exhaled breath and saliva has attracted great attention all over the world. Among various analytical methods, biosensors can offer non-invasive, efficient, and cost-effective diagnostic capabilities, emerging as promising tools in this area. This review intends to provide a comprehensive overview of various biosensors for the detection of respiratory disease related biomarkers in exhaled breath and saliva. Firstly, the characteristics of exhaled breath and saliva, including their generation, composition, and relevant biomarkers are introduced. Subsequently, the design and application of various biosensors for detecting these biomarkers are presented, along with the innovative materials employed as sensitive components. Different types of biosensors are reviewed, including electrochemical, optical, piezoelectric, semiconductor, and other novel biosensors. At last, the challenges, limitations, and future trends of these biosensors are discussed. It is anticipated that biosensors will play a significant role in respiratory disease diagnosis in the future.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biosensing Techniques",
+ "Biomarkers",
+ "Saliva",
+ "Breath Tests",
+ "Respiratory Tract Diseases",
+ "Exhalation",
+ "Electrochemical Techniques",
+ "Equipment Design"
+ ]
+ },
+ {
+ "PMID": "39370174",
+ "Title": "The Indian journal of tuberculosis",
+ "ArticleTitle": "Psychological comorbidities: Impact on respiratory health.",
+ "Abstract": "Respiratory diseases are commonly associated with mental health issues, which add to morbidity and mortality. However, this association has never received sufficient attention. There is an urgent need to sensitize the health care workers for early identification of psychological comorbidities, and their basic management. Mental health should be an integral part of the teaching curriculum. Simple, quick and easy to use screening questionnaires should be used on a routine basis for identifying stigma, psychological distress and poor health related quality of life. Psychiatrist should be a vital part of the multidisciplinary teams. Extensive collaborative research needs to be carried out in this field to devise clear-cut recommendations for day-to-day practise.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Comorbidity",
+ "Mental Disorders",
+ "Respiratory Tract Diseases",
+ "Quality of Life",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39370173",
+ "Title": "The Indian journal of tuberculosis",
+ "ArticleTitle": "Psychological disorders in tuberculosis and respiratory diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mental Disorders",
+ "Tuberculosis, Pulmonary",
+ "Tuberculosis",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39366894",
+ "Title": "Revue des maladies respiratoires",
+ "ArticleTitle": "[The impact of maternal smoking during pregnancy on respiratory disease in children].",
+ "Abstract": "Among the causes of abnormal fetal lung development, active and environmental maternal smoking represents a major potential target in preventive medicine. Prevalence of smoking among women, particularly during pregnancy, varies across the different regions of the world. We reviewed the literature on the repercussions of maternal smoking on the lungs of the fetus and the neonate. One of the main consequences is prematurity, leading to pulmonary bronchodysplasia followed by respiratory infections, which particularly affect young children. In the medium- and long-term, smoking in utero leads to asthma and allergies, and is suspected to be associated with impaired respiratory function in children and teenagers. We also report on the potential effects of e-cigarettes, which represent an emerging threat to children's respiratory health.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pregnancy",
+ "Female",
+ "Prenatal Exposure Delayed Effects",
+ "Smoking",
+ "Child",
+ "Infant, Newborn",
+ "Respiratory Tract Diseases",
+ "Adolescent",
+ "Maternal Exposure"
+ ]
+ },
+ {
+ "PMID": "39364938",
+ "Title": "The Veterinary record",
+ "ArticleTitle": "Managing respiratory cases during supply issues.",
+ "Abstract": "",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "United Kingdom",
+ "Veterinary Medicine",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39362458",
+ "Title": "Environmental research",
+ "ArticleTitle": "Health effects of greenspace morphology: Large, irregular-shaped, well-connected, and close-clustered greenspaces may reduce mortality risks, especially for neighborhoods with higher aging levels.",
+ "Abstract": "The healthcare burden has intensified with urbanization and aging populations in many global cities. While the health effects of urban greenspaces have been well documented, little is known about the associations between greenspace morphological features and health, especially in a high-density city with significant aging populations. Drawing on land use data with 10-m resolution, we assessed seven greenspace morphological metrics in terms of size (the percentage of greenspace, the largest pixel index, the average greenspace area), fragmentation (the patch density), shape (the average weighted shape index), connectedness (the cohesion index), and proximity (the aggregation index). We further conducted an ecological study to examine their associations with all-cause and three cause-specific (cardiovascular disease, respiratory disease, and cancer) mortality. Results from the negative binomial regression models revealed protective effects of five greenspace morphology metrics, including the percentage of greenspace, the largest pixel index, the average weighted shape index, the cohesion index, and the aggregation index, on mortality. The shape index showed the greatest effects, with every 1 Standard Deviation (SD) increase in the shape index linked to a reduction of 22.1% (95% CI: 22.0%-31.0%) in all-cause mortality, 22.1% (12.2%-30.8%) in mortality from cardiovascular diseases, 25.0% (14.0%-34.6%) in mortality from respiratory diseases, and 22.0% (12.3%-30.6%) in mortality from cancers. Moreover, stratified analyses revealed that the health effects of the cohesion index and the aggregation index were significantly more pronounced in neighborhoods with higher aging levels. Our findings highlight the significance of greenspace morphology features, beyond greenspace quantity, in improving residents' health, particularly for societies with high aging populations.",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Residence Characteristics",
+ "Aged",
+ "Mortality",
+ "Cities",
+ "Middle Aged",
+ "Aging",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Neoplasms",
+ "Respiratory Tract Diseases",
+ "Adult",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39362179",
+ "Title": "Respiratory investigation",
+ "ArticleTitle": "Feasibility of a problem-solving exercise program based on short physical performance battery for older patients with chronic respiratory diseases: A multicenter, pilot clinical trial.",
+ "Abstract": "University Hospital Medical Information Network Center (UMIN-CTR) UMIN: approval number: UMIN000048761.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Feasibility Studies",
+ "Pilot Projects",
+ "Aged",
+ "Male",
+ "Chronic Disease",
+ "Female",
+ "Exercise Therapy",
+ "Prospective Studies",
+ "Problem Solving",
+ "Physical Functional Performance",
+ "Aged, 80 and over",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39353528",
+ "Title": "Environmental research",
+ "ArticleTitle": "Diurnal temperature range and cardiopulmonary health in Taiwan: Evaluating impacts, thresholds, and vulnerable groups.",
+ "Abstract": "The health impacts of the diurnal temperature range (DTR), which may be affected by climate change, have received little attention. The objectives of this study were (1) to evaluate the association of DTR and cardiopulmonary outcomes, (2) to select the proper thresholds for a DTR warning system, and (3) to identify vulnerable groups. The weather and health records in Taiwan from 2000 to 2019, with a maximum DTR of 12.8\u00a0\u00b0C, were analyzed using generalized additive models. The health outcomes included cardiovascular (CVD) and respiratory disease (RD) categories and several sub-categories, such as ischemic heart disease, stroke, pneumonia, asthma, and chronic obstructive pulmonary disease. The results showed that the associations of DTR and cardiopulmonary outcomes were as significant as, and sometimes even stronger than, those of the daily maximum temperature and daily minimum apparent temperature in the warm and cold seasons, respectively. The significant association began at DTR of 6\u00a0\u00b0C, lower than previously reported. The identified DTR warning thresholds were 8.5 and 11\u00a0\u00b0C for the warm and cold seasons, respectively. DTR is statistically significantly associated with a 5-36% and a 9-20% increase in cardiopulmonary emergency and hospitalized cases in the warm season with a 1\u00a0\u00b0C increase above 8.5\u00a0\u00b0C, respectively. In the cold season, DTR is significantly associated with 7-41%, 4-30%, and 36-100% increases in cardiopulmonary emergency, hospitalized, and mortality with a 1\u00a0\u00b0C increase above 11\u00a0\u00b0C, respectively. People with hypertension, hyperglycemia, and hyperlipidemia had even higher risks. Vulnerable age and sex groups were identified if they had a lower DTR-health threshold than the general population, which can be integrated into a warning system. In conclusion, DTR may be increased on a local or city scale under climate change; a DTR warning system and vulnerable group identification may be warranted in most countries for health risk reduction.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Taiwan",
+ "Humans",
+ "Cardiovascular Diseases",
+ "Climate Change",
+ "Temperature",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Respiratory Tract Diseases",
+ "Male",
+ "Female",
+ "Seasons",
+ "Vulnerable Populations",
+ "Young Adult",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39354585",
+ "Title": "Radiation oncology (London, England)",
+ "ArticleTitle": "Respiratory adverse effects in patients treated with immune checkpoint inhibitors in combination with radiotherapy: a systematic review and meta-analysis.",
+ "Abstract": "Our meta-analysis demonstrated that ICI combined with radiotherapy for solid tumors can produce respiratory adverse effects. ICIs combination treatment, a tumor located in the chest, is more likely to cause adverse reactions, and SBRT treatment and synchronous treatment will bring less incidence of adverse reactions. This study provide insights for clinicians to balance the risks of radiotherapy in the course of treating oncology patients.",
+ "Predictions": [
+ "Cancer",
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Immune Checkpoint Inhibitors",
+ "Neoplasms",
+ "Chemoradiotherapy",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39352090",
+ "Title": "Central European journal of public health",
+ "ArticleTitle": "Occupational respiratory disease in Eastern Slovakia between 1990-2021: a shift from agriculture to industrial manufacturing.",
+ "Abstract": "This study found a decrease in the number of OA cases, as well as changes in economic sectors and causal agents associated with OA and OHP, specifically, in the agricultural sector, with MWFs from the industrial manufacturing sector now being the most common aetiological agent.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Slovakia",
+ "Occupational Diseases",
+ "Adult",
+ "Male",
+ "Female",
+ "Prevalence",
+ "Middle Aged",
+ "Agriculture",
+ "Occupational Exposure",
+ "Manufacturing Industry",
+ "Asthma, Occupational",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39348213",
+ "Title": "Journal of the Air & Waste Management Association (1995)",
+ "ArticleTitle": "Combined health effects of air pollutant mixtures on respiratory mortality using BKMR in Hangzhou, China.",
+ "Abstract": "Previous research on respiratory system mortality primarily focused on understanding their combined effects and have neglected the fact that air pollution mixtures are interrelated. This study used Bayesian kernel machine regression (BKMR) to analyze the relationship between air pollutant mixtures and respiratory mortality in Hangzhou, China from 2014 to 2018. The results showed a significant association between pollutant mixtures and respiratory system mortality primarily driven by PM",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "China",
+ "Air Pollutants",
+ "Humans",
+ "Bayes Theorem",
+ "Particulate Matter",
+ "Air Pollution",
+ "Respiratory Tract Diseases",
+ "Sulfur Dioxide",
+ "Environmental Exposure"
+ ]
+ },
+ {
+ "PMID": "39338131",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Thermal Comfort Conditions and Mortality in Brazil.",
+ "Abstract": "Conventional temperature-based approaches often overlook the intricate nature of thermal stress experienced by individuals. To address this limitation, climatologists have developed thermal indices-composite measures designed to reflect the complex interaction of meteorological factors influencing human perception of temperature. Our study focuses on Brazil, estimating the association between thermal comfort conditions and mortality related to respiratory and circulatory diseases. We examined four distinct thermal indices: the discomfort index (DI), net effective temperature (NET), humidex (H), and heat index (HI). Analyzing a comprehensive dataset of 2,872,084 deaths from 2003 to 2017, we found significant variation in relative risk (RR) based on health outcomes, exposure lag, percentile of exposure, sex/age groups, and specific thermal indices. For example, under high exposure conditions (99th percentile), we observed that the shorter lags (3, 5, 7, and 10) had the most robust effects on all-cause mortality. For example, under lag 3, the pooled national results for the overall population (all ages and sexes) indicate an increased risk of all-cause mortality, with an RR of 1.17 (95% CI: 1.13; 1.122) for DI, 1.15 (95% CI: 1.12; 1.17) for H, 1.15 (95% CI: 1.09; 1.21) for HI, and 1.18 (95% CI: 1.13; 1.22) for NET. At low exposure levels (1st percentile), all four distinct thermal indices were linked to an increase in all-cause mortality across most sex and age subgroups. Specifically, for lag 20, we observed an estimated RR of 1.19 (95% CI: 1.14; 1.23) for DI, 1.12 (95% CI: 1.08; 1.16) for H, 1.17 (95% CI: 1.12; 1.22) for HI, and 1.18 (95% CI: 1.14; 1.23) for NET. These findings have important implications for policymakers, guiding the development of measures to minimize climate change's impact on public health in Brazil.",
+ "Predictions": [
+ "Chronic respiratory disease",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Brazil",
+ "Humans",
+ "Male",
+ "Female",
+ "Mortality",
+ "Middle Aged",
+ "Adult",
+ "Adolescent",
+ "Aged",
+ "Child",
+ "Young Adult",
+ "Respiratory Tract Diseases",
+ "Infant",
+ "Child, Preschool",
+ "Cardiovascular Diseases",
+ "Temperature",
+ "Hot Temperature",
+ "Aged, 80 and over",
+ "Infant, Newborn"
+ ]
+ },
+ {
+ "PMID": "39334540",
+ "Title": "The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease",
+ "ArticleTitle": "Health status of Italian children living close to cultivations sprayed with pesticides.",
+ "Abstract": "<sec><title>BACKGROUND</title>Pesticides are used to control pests, but they are toxic and may severely harm children's health. We assessed health outcomes in Italian children living close to cultivations sprayed with pesticides.</sec><sec><title>METHODS</title>In 2011-2012, 2,367 schoolchildren (6-14 years) living in eight Italian cities participated in the Indoor-School observational study. Parents filled in a standardised questionnaire on children's health and related risk factors. Children were classified as exposed to pesticides if living close to cultivations sprayed with pesticides. The association between the last three months of respiratory, allergic or systemic symptoms and pesticide exposure was assessed by multinomial logistic regression models, accounting for host/environmental risk factors.</sec><sec><title>RESULTS</title>Overall, 14% of children were exposed to pesticides, with significant differences among geographical areas: 21.2% in Northern Italy, 11.6% in Central Italy, and 9.7% in Southern Italy. Pesticide exposure was significantly associated with having: 1) 'often': eye symptoms (OR 3.81, 95% CI 2.06-7.05), skin symptoms (OR 2.60, 95% CI 1.34-5.03), lower airway symptoms (OR 2.38, 95% CI 1.41-4.01), systemic symptoms (OR 1.56, 95% CI 0.96-2.53, borderline); 2) 'daily': upper airways symptoms (OR 2.25, 95% CI 1.25-4.07) and systemic symptoms (OR 2.76, 95% CI 1.43-5.34).</sec><sec><title>CONCLUSIONS</title>Self-reported pesticide exposure was associated with respiratory, allergic or systemic symptoms in children. Public authorities should be aware of and intervene to mitigate this health risk.</sec>.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Italy",
+ "Child",
+ "Pesticides",
+ "Female",
+ "Male",
+ "Adolescent",
+ "Environmental Exposure",
+ "Surveys and Questionnaires",
+ "Risk Factors",
+ "Health Status",
+ "Logistic Models",
+ "Agriculture",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39332351",
+ "Title": "International journal of hygiene and environmental health",
+ "ArticleTitle": "Systematic review of impacts of occupational exposure to wildfire smoke on respiratory function, symptoms, measures and diseases.",
+ "Abstract": "This review found a convincing body of evidence that occupational exposure to wildfires or prescribed burns has both acute and possibly longer-term respiratory effects among WFFs and some other emergency personnel. Given that these events are increasing, more needs to be done to identify those most at risk and mitigate these risks.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Wildfires",
+ "Smoke",
+ "Occupational Exposure",
+ "Firefighters",
+ "Respiratory Tract Diseases",
+ "Respiratory Function Tests"
+ ]
+ },
+ {
+ "PMID": "39331188",
+ "Title": "Neurosurgical review",
+ "ArticleTitle": "Epidemiology and risk factors for adult gliomas died by respiratory diseases during the COVID-19 pandemic: a population-based study.",
+ "Abstract": "RDs have become a crucial cause of death for gliomas. Those with advanced age and lower median household income have a higher risk of dying from respiratory diseases. Surgical treatment has been found to be safe for glioma patients and has been shown to reduce the risk of glioma patients dying from respiratory diseases. The study provides valuable insights for the perioperative management of gliomas patients in the post-pandemic era.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Glioma",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Risk Factors",
+ "Adult",
+ "Aged",
+ "Brain Neoplasms",
+ "SEER Program",
+ "Young Adult",
+ "Pandemics",
+ "Respiratory Tract Diseases",
+ "SARS-CoV-2"
+ ]
+ },
+ {
+ "PMID": "39323116",
+ "Title": "Pediatric pulmonology",
+ "ArticleTitle": "The epidemiology of critical respiratory diseases in ex-premature infants in Vietnam: A prospective single-center study.",
+ "Abstract": "EPIs with critical respiratory illnesses constituted a significant population in the PICU, required more PICU support, and had worse clinical outcomes compared to term infants.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Vietnam",
+ "Male",
+ "Female",
+ "Prospective Studies",
+ "Infant",
+ "Infant, Newborn",
+ "Intensive Care Units, Pediatric",
+ "Infant, Premature",
+ "Critical Illness",
+ "Respiration, Artificial",
+ "Length of Stay",
+ "Child, Preschool",
+ "Respiratory Tract Diseases",
+ "Infant, Premature, Diseases"
+ ]
+ },
+ {
+ "PMID": "39316790",
+ "Title": "JMIR public health and surveillance",
+ "ArticleTitle": "The Effect of Long-Term Particulate Matter Exposure on Respiratory Mortality: Cohort Study in China.",
+ "Abstract": "This cohort study provides causal clues of the respiratory impact of long-term ambient PM exposure, indicating that PM reduction efforts may continuously benefit the population's respiratory health.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Particulate Matter",
+ "China",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Cohort Studies",
+ "Environmental Exposure",
+ "Adult",
+ "Respiratory Tract Diseases",
+ "Aged",
+ "Air Pollutants",
+ "Air Pollution"
+ ]
+ },
+ {
+ "PMID": "39316681",
+ "Title": "American journal of physiology. Lung cellular and molecular physiology",
+ "ArticleTitle": "Mechanisms of mechanical stimulation in the development of respiratory system diseases.",
+ "Abstract": "During respiration, mechanical stress can initiate biological responses that impact the respiratory system. Mechanical stress plays a crucial role in the development of the respiratory system. However, pathological mechanical stress can impact the onset and progression of respiratory diseases by influencing the extracellular matrix and cell transduction processes. In this article, we explore the mechanisms by which mechanical forces communicate with and influence cells. We outline the basic knowledge of respiratory mechanics, elucidating the important role of mechanical stimulation in influencing respiratory system development and differentiation from a microscopic perspective. We also explore the potential mechanisms of mechanical transduction in the pathogenesis and development of respiratory diseases such as asthma, lung injury, pulmonary fibrosis, and lung cancer. Finally, we look forward to new research directions in cellular mechanotransduction, aiming to provide fresh insights for future therapeutic research on respiratory diseases.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Animals",
+ "Respiratory Tract Diseases",
+ "Mechanotransduction, Cellular",
+ "Stress, Mechanical",
+ "Extracellular Matrix",
+ "Respiratory Mechanics"
+ ]
+ },
+ {
+ "PMID": "39314792",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Causal effects of air pollutants on lung function and chronic respiratory diseases: a Mendelian randomization study.",
+ "Abstract": "Our study ascertained the causal correlations of air pollutants with lung function and COPD, emphasizing the importance of reducing air pollution. Interleukin-17A mediates the reduction of FEV",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Air Pollutants",
+ "Particulate Matter",
+ "Respiratory Function Tests",
+ "Air Pollution",
+ "Nitrogen Dioxide",
+ "Environmental Exposure",
+ "Chronic Disease",
+ "Male",
+ "Forced Expiratory Volume",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39304964",
+ "Title": "Italian journal of pediatrics",
+ "ArticleTitle": "Clinical application of flexible fiberoptic bronchoscopy in neonatal respiratory diseases.",
+ "Abstract": "Flexible bronchoscopy could play an important role in diagnosing and identifying respiratory disorders in neonates and be safely used with few serious complications.",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bronchoscopy",
+ "Infant, Newborn",
+ "Retrospective Studies",
+ "Male",
+ "Female",
+ "Fiber Optic Technology",
+ "Respiratory Tract Diseases"
+ ]
+ },
+ {
+ "PMID": "39293035",
+ "Title": "Pediatric allergy, immunology, and pulmonology",
+ "ArticleTitle": "Pharmaceutical Therapies for Pediatric Respiratory Disease: Setbacks and Progress in 2024.",
+ "Abstract": "",
+ "Predictions": [
+ "Chronic respiratory disease"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "Respiratory Tract Diseases",
+ "Pediatrics"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/diabetes.json b/model/dataset/diabetes.json
new file mode 100644
index 0000000000000000000000000000000000000000..b65ca4eaaf22f89f7053cd993e032c6359b25592
--- /dev/null
+++ b/model/dataset/diabetes.json
@@ -0,0 +1,2349 @@
+[
+ {
+ "PMID": "39738300",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Robust self management classification via sparse representation based discriminative model for mild cognitive impairment associated with diabetes mellitus.",
+ "Abstract": "Diabetes Mellitus combined with Mild Cognitive Impairment (DM-MCI) is a high incidence disease among the elderly. Patients with DM-MCI have considerably higher risk of dementia, whose daily self-care and life management (i.e. self-management) have a significant impact on the development of their condition. Thus, the inclusion and discrimination of subsequent interventions according to their self-management is an urgent issue. A Sparse-representation-based Discriminative Classification model (SDC) is proposed in this paper to correctly classify MCI-DM patients based on their self-management ability. Specifically, an L",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cognitive Dysfunction",
+ "Self-Management",
+ "Machine Learning",
+ "Aged",
+ "Male",
+ "Female",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39737509",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "ICMR-MDRF Diabetes Biosamples: Cohort profile.",
+ "Abstract": "Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR). The ICMR-INDIAB study is the largest epidemiological study on diabetes in India, encompassing a nationally representative sample of individuals aged 20 yr and older from urban and rural areas in every State across the country. The ICMR-YDR is the first national-level, multicentric clinic-based registry focusing on youth-onset diabetes in India, aiming to understand the disease patterns and variations in youth-onset diabetes across different country regions. Results Key operations at the MDRF biobank include collecting and processing samples, where serum and whole blood samples are aliquoted and transferred through a cold chain to the central laboratory, and then stored in Siruseri (29 km from the capital city of Chennai, Tamil Nadu). Samples are barcoded, linked to subject information, and stored in freezers or liquid nitrogen (LN2) vessels, with inventory tracked via software for easy retrieval. A register records access to the biobank, ensuring sample integrity and compliance with regulatory requirements. The biobank adheres to the ICMR's National Ethical Guidelines for Biomedical and Health Research involving human participants. Interpretation & conclusions The biobank enables the analysis of biomarkers in stored samples, aiding in scientifically sound decisions, treating patients, and potentially curing diabetes.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Biological Specimen Banks",
+ "Adult",
+ "Female",
+ "Male",
+ "Diabetes Mellitus",
+ "Registries",
+ "Biomedical Research",
+ "Young Adult",
+ "Cohort Studies",
+ "Age of Onset",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39736942",
+ "Title": "Archives of Razi Institute",
+ "ArticleTitle": "Morbidity profile of the patients attending Mobile Medical Unit camps in Telangana: A record-based study.",
+ "Abstract": "Mobile Medical Units (MMUs) are one of the major initiatives under the National Rural Health Mission. These MMUs help people in remote, underserved areas access healthcare at affordable prices on their doorstep. The present record-based study aimed to assess the morbidity profile of the patients attending Mobile Medical Unit camps in the Yadadri-Bhuvanagiri district between April 2022 and December 2022. The MMU is run by the Department of Community and Family Medicine, AIIMS, Bibinagar, in six selected villages of the Yadadri-Bhuvanagiri district. A register is maintained to record the details of patients visiting the MMU camp. Patient's name, age, gender, place, mobile number, height, weight, blood pressure (BP), glucometer Random Blood Sugar, diagnosis, and details of medication dispensed were entered in the register. Diabetes, hypertension, and obesity were diagnosed using the World Health Organization\u00a0(WHO) criteria, the Eighth Joint National Committee guidelines, and WHO Asia Pacific guidelines, respectively. Mobile Medical Unit Camp data are entered into the Excel database at the end of every month. Since it is a record-based analysis, we used data for analysis between April 7, 2022, and December 31, 2022. A total of 1494 patients were treated in the MMU camps during this period. Among them, 89.4% were adults, and 10.6% were children (less than 18 years). Among 1,336 adult patients, the majority of participants suffered from osteoarthritis, followed by non-communicable diseases (NCDs). The mean scores of systolic and diastolic BP of the adult population were obtained at 131\u00b121 and 77\u00b113 mm Hg, respectively. The mean random blood glucose level of the adult population was 150\u00b174 mg/dl. A total of 158 children were younger than 18 years old, out of whom 78 and 80 participants were males and females, respectively. Moreover, 23.1% and 25% of males and females suffered from upper respiratory tract infections, respectively. The study further suggests that the NCD epidemic is spreading to rural areas where necessary health infrastructure is insufficient. MMUs can bring a significant change to the public health system, which needs to re-orient its priorities.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Adult",
+ "Mobile Health Units",
+ "Middle Aged",
+ "Adolescent",
+ "Aged",
+ "Child",
+ "Young Adult",
+ "India",
+ "Morbidity",
+ "Hypertension",
+ "Child, Preschool",
+ "Obesity",
+ "Infant",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39736689",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort.",
+ "Abstract": "This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.",
+ "Predictions": [
+ "Diabetes",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Neoplasms",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Longitudinal Studies",
+ "Aged",
+ "Proportional Hazards Models",
+ "Diabetes Mellitus",
+ "Risk Factors",
+ "Cardiometabolic Risk Factors",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39735640",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Atypical diabetes arising from SHORT syndrome: a case report.",
+ "Abstract": "Short stature, joint hyperextension, ocular hypotension, Rieger abnormalities, and delayed tooth eruption (SHORT) syndrom is a rare primary autosomal dominant genetic disorder mainly caused by pathogenic loss-of-function variants in the phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) gene. We report the case of a Chinese adult female patient with SHORT syndrome, carrying a PIK3R1 gene variant (c.1945C > T), who developed abnormal glucose metabolism and severe postprandial insulin resistance over 9 years. Although there are currently no established treatment guidelines for insulin resistance in patients with SHORT syndrome, we implemented a comprehensive treatment plan, including lifestyle interventions, metformin, and voglibose for glucose control. After 6 months of continuous observation, the patient's blood glucose levels and insulin resistance improved significantly. This case study provides useful insights for future treatment strategies.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Blood Glucose",
+ "Class Ia Phosphatidylinositol 3-Kinase",
+ "Diabetes Mellitus",
+ "Growth Disorders",
+ "Hypercalcemia",
+ "Insulin Resistance",
+ "Nephrocalcinosis",
+ "Tooth Abnormalities"
+ ]
+ },
+ {
+ "PMID": "39735551",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "CD73: agent development potential and its application in diabetes and atherosclerosis.",
+ "Abstract": "CD73, an important metabolic and immune escape-promoting gene, catalyzes the hydrolysis of adenosine monophosphate (AMP) to adenosine (ADO). AMP has anti-inflammatory and vascular relaxant properties, while ADO has a strong immunosuppressive effect, suggesting that CD73 has pro-inflammatory and immune escape effects. However, CD73 also decreased proinflammatory reaction, suggesting that CD73 has a positive side to the body. Indeed, CD73 plays a protective role in diabetes, while with age, CD73 changes from anti-atherosclerosis to pro-atherosclerosis. The upregulation of CD73 with agents, including AGT-5, Aire-overexpressing DCs, Aspirin, BAFFR-Fc, CD4+ peptide, ICAs, IL-2 therapies, SAgAs, sCD73, stem cells, RAD51 inhibitor, TLR9 inhibitor, and VD, decreased diabetes and atherosclerosis development. However, the downregulation of CD73 with agents, including benzothiadiazine derivatives and CD73 siRNA, reduced atherosclerosis. Notably, many CD73 agents were investigated in clinical trials. However, no agents were used to treat diabetes and atherosclerosis. Most agents were CD73 inhibitors. Only FP-1201, a CD73 agonist, was investigated in clinical trials but its further development was discontinued. In addition, many lncRNAs, circRNAs, and genes are located at the same chromosomal location as CD73. In particular, circNT5E promoted CD73 expression. circNT5E may be a promising target for agent development. This mini-review focuses on the current state of knowledge of CD73 in diabetes, atherosclerosis, and its potential role in agent development.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Atherosclerosis",
+ "5'-Nucleotidase",
+ "Animals",
+ "Diabetes Mellitus",
+ "GPI-Linked Proteins",
+ "Drug Development"
+ ]
+ },
+ {
+ "PMID": "39735480",
+ "Title": "Turkish journal of medical sciences",
+ "ArticleTitle": "Burden of comorbidities in heart failure patients in T\u00fcrkiye.",
+ "Abstract": "The most common comorbidities in cases of HF in T\u00fcrkiye are HT, ASCVD, dyslipidemia, DM, COPD, anemia, and AF, respectively, and more than 90% of patients have \u22652 comorbidities. While ASCVD and dyslipidemia were more common in male patients, anemia, DM, and anxiety disorders were more common in female patients. The number of comorbid conditions increased with advanced age.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Heart Failure",
+ "Comorbidity",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Turkey",
+ "Prevalence",
+ "Young Adult",
+ "Adolescent",
+ "Aged, 80 and over",
+ "Hypertension",
+ "Diabetes Mellitus",
+ "Pulmonary Disease, Chronic Obstructive",
+ "Anemia",
+ "Dyslipidemias"
+ ]
+ },
+ {
+ "PMID": "39734205",
+ "Title": "Journal of nanobiotechnology",
+ "ArticleTitle": "Nanoparticle and microparticle-based systems for enhanced oral insulin delivery: A systematic review and meta-analysis.",
+ "Abstract": "Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, and allergic reactions. Nanoparticle carriers for oral insulin are groundbreaking compared to existing methods because they are non-invasive treatments, showing operational convenience, controlled release profile, and ability to simulate the physiological delivery route into the bloodstream. These systems improve patient adherence and have demonstrated the potential to lower blood glucose levels in DM. We present a systematic review and meta-analysis aimed at compiling relevant data to pave the way for developing innovative nano- and microparticles for the oral delivery of insulin. Our analysis of 85 articles revealed that the diminution of glucose levels is not proportional to the administered insulin dosage, which ranged from 1 to 120 International Units (IU). The meta-analysis data indicated that 25\u00a0IU of encapsulated porcine insulin did not produce a statistically significant outcome (p\u2009=\u20090.93). In contrast, a dosage of 30\u00a0IU was efficacious in eliciting an optimal hypoglycemic effect compared to excipient controls. Parameters such as a high degree of encapsulation (~ 90%), particle size (200-400\u00a0nm), and polydispersity index (0.086-0.3) are all associated with lower blood glucose levels. These parameters were also significant in the linear regression analysis. Among the excipients employed, chitosan emerged as a prevalent excipient in formulations due to its biocompatible and biodegradable properties and its ability to establish stable polymeric matrices. Even though oral insulin administration is a promising therapeutic method, it cannot guarantee preclinical safety and therapeutic efficacy yet in regulating glucose levels in diabetic conditions.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Administration, Oral",
+ "Insulin",
+ "Humans",
+ "Animals",
+ "Nanoparticles",
+ "Blood Glucose",
+ "Diabetes Mellitus",
+ "Particle Size",
+ "Hypoglycemic Agents",
+ "Drug Carriers",
+ "Drug Delivery Systems"
+ ]
+ },
+ {
+ "PMID": "39733376",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Analysis of laboratory tests in adults with diabetes in Hungary].",
+ "Abstract": "",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hungary",
+ "Male",
+ "Female",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Adult",
+ "Diabetes Mellitus",
+ "Blood Glucose",
+ "Glycated Hemoglobin",
+ "Aged",
+ "Clinical Laboratory Techniques",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39732905",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Predictive value of system immune-inflammation index for the severity of coronary stenosis in patients with coronary heart disease and diabetes mellitus.",
+ "Abstract": "Coronary heart disease (CHD) has been recognized as a chronic progressive inflammatory disorder, and Diabetes mellitus (DM) is an independent risk factor for the pathogenesis of CHD. Recent research has underscored the systemic immune-inflammation index (SII) as a potent prognostic indicator for individuals suffering from acute coronary syndrome (ACS). This study aimed to delve into the relationship between SII and the degree of coronary atherosclerotic stenosis in non-acute myocardial infarction patients with or without DM. We enrolled a total of 2760 patients with cardiovascular disease between November 2023 and May 2024. All eligible participants were divided into the CHD group and the DM & CHD group according to the existence of comorbid DM. Our study revealed that the SII values were significantly higher in diabetic patients with CHD compared to those with CHD alone (P\u2009<\u20090.05). Furthermore, among patients with both CHD and DM, higher SII values were associated with a greater likelihood of developing complex, triple-branch coronary artery lesions, while the opposite trend was observed in CHD populations (P\u2009<\u20090.05). In the regression model completely adjusted for potential confounders, the correlation between high SII levels and co-existing DM status in CHD patients persisted as statistically significant even after attaining guideline-recommended LDL-C and TG goals (P\u2009<\u20090.05). Moreover, our findings demonstrated a significant link between SII levels and the severity of coronary artery stenosis as assessed by coronary angiography, particularly in the DM and CHD patient cohorts (P\u2009<\u20090.05). Further stratified analysis revealed a novel finding that SII levels in DM and CHD patients maintained a positive linear relationship with coronary plaque burden even under stringent glycemic control (P\u2009<\u20090.01, r\u2009=\u20090.37), whereas this correlation was absent in CHD patients who had FBG of 7\u00a0mmol/L or lower upon admission (P\u2009<\u20090.01, r\u2009<\u20090.30). These important findings underscore the SII as an independent predictor of the severity of coronary plaque burden in diabetic patients with CHD, offering valuable insights that can aid clinicians in refining risk stratification and implementing personalized management strategies for those at elevated risk.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Coronary Stenosis",
+ "Aged",
+ "Inflammation",
+ "Coronary Disease",
+ "Severity of Illness Index",
+ "Diabetes Mellitus",
+ "Prognosis",
+ "Risk Factors",
+ "Predictive Value of Tests"
+ ]
+ },
+ {
+ "PMID": "39732874",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association between anion gap/calcium ratio and 30-day all-cause mortality in sepsis patients with diabetes mellitus.",
+ "Abstract": "We aimed to determine the association between anion gap-to-calcium ratio (ACR) and 30-day mortality in sepsis patients with diabetes mellitus (DM). Data for sepsis patients diagnosed with DM was extracted from Medical Information Mart for Intensive Care Database IV. After screening, 4429 eligible subjects were included in our study finally. The receiver operating characteristic (ROC) curve was used to determine the cut-off value. According to the ROC curve analysis, the ACR demonstrated a higher area under the curve (AUC) of 0.622 compared to AG (0.598). Multivariable logistic regression with inverse probability of treatment weighting (IPTW) based on propensity score were used to detect the association between ACR and 30-day mortality. Our results showed that the patients with the high level of ACR had a higher risk of death within 30\u00a0days compared with those with low level of ACR (odds ratio 1.342, 95% confidence interval 1.180-1.526, P\u2009<\u20090.001). In a word, our results suggest that ACR may be an independent prognostic indicator for death with 30\u00a0days in critically ill patients with sepsis and DM.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sepsis",
+ "Male",
+ "Female",
+ "Aged",
+ "Middle Aged",
+ "Calcium",
+ "Diabetes Mellitus",
+ "Acid-Base Equilibrium",
+ "ROC Curve",
+ "Prognosis"
+ ]
+ },
+ {
+ "PMID": "39732729",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.",
+ "Abstract": "Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and plays a pivotal role in the pathogenesis of vascular diseases such as atherosclerosis, hypertension, and vascular inflammation. In cardiometabolic diseases, PVAT becomes a significant source of proflammatory adipokines, leading to increased infiltration of immune cells, in cardiometabolic diseases, PVAT becomes a significant source of proinflammatory adipokines, leading to increased infiltration of immune cells, promoting vascular smooth muscle cell proliferation and migrationpromoting vascular smooth muscle cell proliferation and migration. This exacerbates vascular dysfunction by impairing endothelial cell function and promoting endothelial activation. Dysregulated PVAT also contributes to hemodynamic alterations and hypertension through enhanced sympathetic nervous system activity and impaired vasodilatory capacity of PVAT-derived factors. Therapeutic interventions targeting key components of this interaction, such as modulating PVAT inflammation, restoring adipokine balance, and attenuating immune cell activation, hold promise for mitigating obesity-related vascular complications. Lifestyle interventions, pharmacological agents targeting inflammatory pathways, and surgical approaches aimed at reducing PVAT mass or improving adipose tissue function are potential therapeutic avenues for managing vascular diseases associated with obesity and PVAT dysfunction.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Humans",
+ "Adipokines",
+ "Adipose Tissue",
+ "Adiposity",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus",
+ "Inflammation Mediators",
+ "Obesity",
+ "Signal Transduction"
+ ]
+ },
+ {
+ "PMID": "39732433",
+ "Title": "Microvascular research",
+ "ArticleTitle": "Prevalence of microvascular complications and associated factors among diabetes mellitus patients in Ethiopia: Systematic review and meta-analysis.",
+ "Abstract": "The review protocol was developed and was registered with PROSPERO registration number (CRD42023486459).",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Ethiopia",
+ "Risk Factors",
+ "Prevalence",
+ "Diabetic Angiopathies",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Risk Assessment",
+ "Diabetic Retinopathy",
+ "Aged",
+ "Diabetic Nephropathies",
+ "Diabetic Neuropathies",
+ "Diabetes Mellitus",
+ "Young Adult",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39730723",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study.",
+ "Abstract": "Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases. However, current evidence on the association between CMI and kidney stone risk is limited. The primary objective of this study was to investigate the association between CMI and kidney stones in US adults and to analyze whether diabetes mediates the association. Using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and March 2018, this study examined the association between CMI and kidney stones incidence in US adults. Data were analyzed using a variety of statistical methods, including multifactorial logistic regression, subgroup analysis, restricted cubic spline curves (RCS), saturated threshold effects analysis, and mediated effects analysis. A total of 10,609 subjects were included in this study, of which 972 patients were diagnosed with kidney stones. The results of multifactorial logistic regression analysis after fully adjusting for confounding covariates showed a significant positive association between CMI and kidney stones, with an odds ratio (OR) of 1.29 and a 95% confidence interval (CI) of (1.16,1.44). In addition, there was a non-linear positive association between CMI and kidney stones. The results of mediation analysis showed that diabetes mellitus had a mediating role of 15.3% in the correlation between CMI and kidney stones. The findings of this study indicate that elevated CMI levels are associated with an increased risk of kidney stone formation, with diabetes playing a mediating role. These findings indicate that maintaining CMI within the lower range and addressing glycemic regulation is crucial for the prevention of kidney stones.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Kidney Calculi",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Adult",
+ "Diabetes Mellitus",
+ "Nutrition Surveys",
+ "Risk Factors",
+ "Aged",
+ "Cardiovascular Diseases",
+ "United States",
+ "Incidence",
+ "Logistic Models"
+ ]
+ },
+ {
+ "PMID": "39730510",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association of relative fat mass\u00a0(RFM) index with diabetes-related mortality and heart disease mortality.",
+ "Abstract": "Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999-2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n\u2009=\u200914,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Nutrition Surveys",
+ "Heart Diseases",
+ "Diabetes Mellitus",
+ "Waist Circumference",
+ "Body Mass Index",
+ "Adiposity",
+ "Risk Factors",
+ "Adipose Tissue",
+ "United States"
+ ]
+ },
+ {
+ "PMID": "39729755",
+ "Title": "Biosensors & bioelectronics",
+ "ArticleTitle": "A comprehensive review of non-invasive optical and microwave biosensors for glucose monitoring.",
+ "Abstract": "Frequent glucose monitoring is essential for effective diabetes management. Currently, glucose monitoring is done using invasive methods such as finger-pricking and subcutaneous sensing. However, these methods can cause discomfort, heighten the risk of infection, and some sensing devices need frequent calibration. Non-invasive glucose monitoring technologies have attracted significant attention due to their potential to overcome the limitations of their invasive counterparts by offering painless and convenient alternatives. This review focuses on two prominent approaches to non-invasive glucose sensing: optical- and microwave-based methods. On one hand, optical techniques, including Raman and near-infrared (NIR) spectroscopy, leverage the unique spectral properties of glucose molecules to measure their concentration in tissues and biofluids. On the other hand, microwave sensing leverages the dielectric properties of glucose to detect concentration changes based on impedance measurements. Despite their promise, optical- and microwave-based technologies face challenges such as signal interference and high variability due to tissue heterogeneity, which impact their accuracy and reliability. This review provides a comprehensive overview of the advancements of these non-invasive methods, highlighting their technical implementation, limitations, and their future potential in revolutionizing glucose monitoring for diabetes care.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Biosensing Techniques",
+ "Microwaves",
+ "Humans",
+ "Blood Glucose",
+ "Blood Glucose Self-Monitoring",
+ "Diabetes Mellitus",
+ "Spectrum Analysis, Raman",
+ "Spectroscopy, Near-Infrared",
+ "Equipment Design"
+ ]
+ },
+ {
+ "PMID": "39725874",
+ "Title": "BMC cardiovascular disorders",
+ "ArticleTitle": "U-shaped association of uric acid to HDL cholesterol ratio (UHR) with ALL-cause and cardiovascular mortality in diabetic patients: NHANES 1999-2018.",
+ "Abstract": "This study found a U-shaped relationship between UHR and both ALL-cause and cardiovascular mortality in diabetic population. This suggests that clinicians should control UHR around 9-10 to improve the long-term prognosis of diabetic patients.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Uric Acid",
+ "Nutrition Surveys",
+ "Cholesterol, HDL",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus",
+ "Biomarkers",
+ "Risk Assessment",
+ "Cause of Death",
+ "United States",
+ "Time Factors",
+ "Adult",
+ "Longitudinal Studies",
+ "Prognosis",
+ "Aged",
+ "Sex Factors",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39725454",
+ "Title": "BMJ paediatrics open",
+ "ArticleTitle": "\"Effect of post-kidney transplant diabetes mellitus on long-term outcomes in a cohort of pediatric kidney transplant recipients from 2005 to 2022.\" Survival analysis.",
+ "Abstract": "Seventy-six paediatric kidney transplant recipients were included. The incidence of PTDM and iCHO was 6.6% and 9.2%, respectively. Patients with PTDM/iCHO had a significantly higher cumulative graft loss incidence than those without (34.4% vs 13.9% at 36 months, p<0.008). Multivariable analysis revealed a threefold increased risk of graft loss in patients with PTDM/iCHO (HR",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Kidney Transplantation",
+ "Male",
+ "Female",
+ "Child",
+ "Adolescent",
+ "Graft Survival",
+ "Graft Rejection",
+ "Diabetes Mellitus",
+ "Incidence",
+ "Retrospective Studies",
+ "Postoperative Complications",
+ "Survival Analysis",
+ "Child, Preschool",
+ "Transplant Recipients",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39723173",
+ "Title": "International journal of nanomedicine",
+ "ArticleTitle": "Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management.",
+ "Abstract": "Chronic wounds in diabetic patients experience significant clinical challenges due to compromised healing processes. Hypoxia-inducible factor-1 alpha (HIF-1\u03b1) is a critical regulator in the cellular response to hypoxia, enhancing angiogenesis and tissue restoration. Nevertheless, the cellular response to the developed chronic hypoxia within diabetes is impaired, likely due to the destabilization of HIF-1\u03b1 via degradation by prolyl hydroxylase domain (PHD) enzymes. Researchers have extensively explored HIF-1\u03b1 activation as a potential pathway for diabetic wound management, focusing mainly on deferoxamine (DFO) as a potent agent to stabilize HIF-1\u03b1. This review provides an update of the other recent pharmacological agents managing HIF-1\u03b1 activation, including novel PHD inhibitors (roxadustat and daprodustat) and Von Hippel-Lindau protein (VHL) antagonists, which could be potential alternatives for the local treatment of diabetic wounds. Furthermore, it highlights how localized delivery via advanced nanostructures can enhance the efficacy of these novel therapies. Importantly, by addressing these points, the current review can offer a promising area for research. Given that, these novel drugs have minimal applications in diabetic wound healing, particularly in the context of local application through nanomaterials. This gap presents an exciting opportunity for further investigation, as combining these drugs with localized nanotechnology could avoid undesired systemic side effects and sustain drug release within wound site, offering a transformative platform for diabetes wound treatment.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Wound Healing",
+ "Hypoxia-Inducible Factor 1, alpha Subunit",
+ "Animals",
+ "Deferoxamine",
+ "Diabetes Mellitus",
+ "Glycine",
+ "Nanoparticles",
+ "Isoquinolines"
+ ]
+ },
+ {
+ "PMID": "39721299",
+ "Title": "Radiography (London, England : 1995)",
+ "ArticleTitle": "Point shear wave elastography application in assessment pancreas tissue stiffness: A pilot study.",
+ "Abstract": "Point shear wave elastography (pSWE) could be a useful, non-invasive tool for early detection of pancreatic changes in diabetic patients, identifying those at risk for complications. Integrating pSWE into routine diabetes check may enhance early interventions and improve outcomes.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Elasticity Imaging Techniques",
+ "Pilot Projects",
+ "Male",
+ "Female",
+ "Pancreas",
+ "Middle Aged",
+ "Adult",
+ "Case-Control Studies",
+ "Aged",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39720256",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Application of extracellular vesicles in diabetic osteoporosis.",
+ "Abstract": "As the population ages, the occurrence of osteoporosis is becoming more common. Diabetes mellitus is one of the factors in the development of osteoporosis. Compared with the general population, the incidence of osteoporosis is significantly higher in diabetic patients. Diabetic osteoporosis (DOP) is a metabolic bone disease characterized by abnormal bone tissue structure due to hyperglycemia and insulin resistance, reduced bone strength and increased risk of fractures. This is a complex mechanism that occurs at the cellular level due to factors such as blood vessels, inflammation, and hyperglycemia and insulin resistance. Although the application of some drugs in clinical practice can reduce the occurrence of DOP, the incidence of fractures caused by DOP is still very high. Extracellular vesicles (EVs) are a new communication mode between cells, which can transfer miRNAs and proteins from mother cells to target cells through membrane fusion, thereby regulating the function of target cells. In recent years, the role of EVs in the pathogenesis of DOP has been widely demonstrated. In this article, we first describe the changes in the bone microenvironment of osteoporosis. Second, we describe the pathogenesis of DOP. Finally, we summarize the research progress and challenges of EVs in DOP.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Extracellular Vesicles",
+ "Osteoporosis",
+ "Animals",
+ "Diabetes Complications",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39720248",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Associations between non-insulin-based insulin resistance indices and diabetic nephropathy in patients with diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.",
+ "Abstract": "Non-insulin-based insulin resistance indices are significantly associated with the risk of DN. The TyG index is a superior tool for assessing the risk of DN. These indices can assist in identifying patients at risk of DN, thereby enabling the implementation of more effective preventive and therapeutic strategies.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Insulin Resistance",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Diabetic Nephropathies",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "United States",
+ "Adult",
+ "Aged",
+ "Risk Factors",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 2",
+ "Body Mass Index"
+ ]
+ },
+ {
+ "PMID": "39719762",
+ "Title": "The Science of the total environment",
+ "ArticleTitle": "Effects of PM",
+ "Abstract": "Long-term exposure to higher levels of PM",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Particulate Matter",
+ "Hypertension",
+ "Diabetes Mellitus",
+ "Middle Aged",
+ "Air Pollutants",
+ "Humans",
+ "Male",
+ "Prospective Studies",
+ "Air Pollution",
+ "Environmental Exposure",
+ "China",
+ "Aged",
+ "Female"
+ ]
+ },
+ {
+ "PMID": "39719335",
+ "Title": "Wei sheng yan jiu = Journal of hygiene research",
+ "ArticleTitle": "[Distribution and epidemic trends of chronic multimorbidity among adult residents in 10 provinces (autonomous regions)of China in 2009-2023].",
+ "Abstract": "The chronic disease status of the population is mostly combined. There are differences in the multimorbidity patterns of different age groups and genders due to their physiological differences.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Male",
+ "Female",
+ "Adult",
+ "Multimorbidity",
+ "Middle Aged",
+ "Chronic Disease",
+ "Prevalence",
+ "Aged",
+ "Hypertension",
+ "Obesity",
+ "Hyperuricemia",
+ "Dyslipidemias",
+ "Surveys and Questionnaires",
+ "Diabetes Mellitus",
+ "Adolescent",
+ "Rural Population",
+ "Young Adult",
+ "Urban Population"
+ ]
+ },
+ {
+ "PMID": "39719334",
+ "Title": "Wei sheng yan jiu = Journal of hygiene research",
+ "ArticleTitle": "[Status and epidemic trends of major chronic metabolic diseases among adult residents in 10 provinces (autonomous regions) of China in 2009-2023].",
+ "Abstract": "From 2009 to 2023, the prevalence of major chronic metabolic diseases among adults has shown a significant increasing trend, with differences in age, gender, urban-rural areas, and regions.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Prevalence",
+ "Hyperuricemia",
+ "Chronic Disease",
+ "Hypertension",
+ "Metabolic Diseases",
+ "Dyslipidemias",
+ "Aged",
+ "Diabetes Mellitus",
+ "Young Adult",
+ "Rural Population",
+ "Adolescent",
+ "Urban Population",
+ "Nutrition Surveys"
+ ]
+ },
+ {
+ "PMID": "39719258",
+ "Title": "International journal of pharmaceutics",
+ "ArticleTitle": "Mechanistic insights of diabetic wound: Healing process, associated pathways and microRNA-based delivery systems.",
+ "Abstract": "Wounds that represent one of the most critical complications can occur in individuals suffering from diabetes mellitus, and results in the need for hospitalisation and, in severe cases, require amputation. This condition is primarily characterized by infections, persistent inflammation, and delayed healing processes, which exacerbate the overall health of the patients. As per the standard mechanism, signalling pathways such as PI3K/AKT, HIF-1, TGF-\u03b2, Notch, Wnt/\u03b2-Cat, NF-\u03baB, JAK/STAT, TLR, and Nrf2 play major roles in inflammatory, proliferative and remodelling phases of wound healing. However, dysregulation of the above pathways has been seen during the healing of diabetic wounds. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of various genes and signalling pathways which are associated with the process of wound healing. In the past few years, there has been a great deal of interest in the potential of miRNAs as biological agents in the management of a number of disorders. These miRNAs have been shown to modulate expression of genes involved in the healing process of wounds. There have been previous reviews pertaining to clinical trials examining miRNAs in several disorders, but only a few clinical studies have examined involvement of miRNAs in healing of wounds. Considering the therapeutic promise, there are several obstacles concerning their instabilities and inefficient delivery into the target cells. Therefore, this review is an attempt to discuss precise roles of signalling pathways and miRNAs in different phases of wound healing, and their aberrant regulation in diabetic wounds, particularly. It has also compiled a range of delivery mechanisms as well as an overview of the latest findings pertaining to miRNAs and associated delivery systems for improved healing of diabetic wounds.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "MicroRNAs",
+ "Humans",
+ "Wound Healing",
+ "Animals",
+ "Signal Transduction",
+ "Diabetes Complications",
+ "Diabetes Mellitus",
+ "Drug Delivery Systems"
+ ]
+ },
+ {
+ "PMID": "39718458",
+ "Title": "ACS applied bio materials",
+ "ArticleTitle": "Glucose-Responsive Insulin Delivery via Surface-Functionalized Titanium Dioxide Nanoparticles: A Promising Theragnostic against Diabetes Mellitus.",
+ "Abstract": "Glucose-dependent insulin delivery systems have been recognized as a promising approach for controlling blood sugar levels in individuals with diabetes mellitus (DM). Recently, titanium dioxide nanoparticles have garnered huge attention in scientific research for their small size and effective drug delivery capabilities. In this study, we developed alizarin (AL)-capped phenylboronic acid (PBA)-functionalized titanium dioxide nanoparticles (TiO",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Titanium",
+ "Insulin",
+ "Animals",
+ "Hypoglycemic Agents",
+ "Particle Size",
+ "Glucose",
+ "Materials Testing",
+ "Nanoparticles",
+ "Surface Properties",
+ "Biocompatible Materials",
+ "Diabetes Mellitus",
+ "Drug Delivery Systems",
+ "Mice",
+ "Diabetes Mellitus, Experimental",
+ "Humans",
+ "Boronic Acids"
+ ]
+ },
+ {
+ "PMID": "39717102",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Higher remnant cholesterol increases the risk of coronary heart disease and diabetes in postmenopausal women.",
+ "Abstract": "Our study reveals a significant positive correlation between RC levels and the prevalence of CHD, diabetes, and CHD combined with diabetes among postmenopausal women. Understanding these associations could potentially inform targeted prevention and management strategies tailored to this vulnerable population.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Postmenopause",
+ "Middle Aged",
+ "Coronary Disease",
+ "Cholesterol",
+ "Aged",
+ "Diabetes Mellitus",
+ "Nutrition Surveys",
+ "Risk Factors",
+ "Prevalence",
+ "United States",
+ "Cross-Sectional Studies"
+ ]
+ },
+ {
+ "PMID": "39717099",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Exploring the role of NLRP3 infalmmasome in diabetes: a literature review and bibliometric analysis.",
+ "Abstract": "This paper has identified the hot spots and trends concerning the role of NLRP3 infalmmasome in diabetes, thereby providing a valuable reference for future research. Furthermore, it is anticipated that pyroptosis and diabetes-related diseases will become frontier research topics that may garner significant attention in the coming years.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Bibliometrics",
+ "Humans",
+ "NLR Family, Pyrin Domain-Containing 3 Protein",
+ "Inflammasomes",
+ "Diabetes Mellitus",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39716287",
+ "Title": "Trials",
+ "ArticleTitle": "The effect of Sarcomeal\u00ae oral supplementation plus vitamin D3 on muscle parameters and metabolic factors in diabetic sarcopenia patients: study protocol of a randomized controlled clinical trial.",
+ "Abstract": "Iranian Registry of Clinical Trials (ID: IRCT20230831059311N1).",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Aged",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Administration, Oral",
+ "Blood Glucose",
+ "Cholecalciferol",
+ "Creatine",
+ "Diabetes Mellitus",
+ "Dietary Supplements",
+ "Iran",
+ "Muscle Strength",
+ "Muscle, Skeletal",
+ "Oxidative Stress",
+ "Randomized Controlled Trials as Topic",
+ "Sarcopenia",
+ "Treatment Outcome",
+ "Valerates",
+ "Whey Proteins"
+ ]
+ },
+ {
+ "PMID": "39716100",
+ "Title": "BMC nephrology",
+ "ArticleTitle": "Influence of gut flora on diabetes management after kidney transplantation.",
+ "Abstract": "Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus",
+ "Gastrointestinal Microbiome",
+ "Kidney Transplantation",
+ "Postoperative Complications"
+ ]
+ },
+ {
+ "PMID": "39715819",
+ "Title": "Scientific reports",
+ "ArticleTitle": "The effect of an educational program on the knowledge and practices of diabetic patients regarding sharps waste disposal at home.",
+ "Abstract": "The disposal of sharp waste generated at home by diabetic patients poses a major public health problem. This study evaluated an educational program designed to improve patients' knowledge and practices around sharps disposal. A non-equivalent quasi-experimental study was performed at a main diabetic center in Egypt on 100 participants divided into intervention and non-intervention groups. The effect of the interventional program was tested by the evaluation of the improvement in participants' knowledge and practice after two and four months of the program. Initially, there were no differences in knowledge or practice scores between the groups. After the implementation of the program, there was a noticeable difference in subjects' knowledge levels and scores between the two groups, with the intervention group significantly outperforming the non-intervention group (p\u2009<\u20090.001). There was a significant improvement in overall practice scores in the intervention group across post-intervention visits, and they registered a score of 14/16, which matches a good practice level, while in the non-intervention group, the score remained unchanged at 4.4/16, which corresponds to a poor practice level (p\u2009<\u20090.001). These findings suggest that educational programs can effectively increase diabetic patients' knowledge and improve their sharps waste disposal practices.Clinical trial registration number: PACTR202310841894237. Date: 05 October 2023, \"retrospectively registered\".",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Diabetes Mellitus",
+ "Egypt",
+ "Health Knowledge, Attitudes, Practice",
+ "Patient Education as Topic"
+ ]
+ },
+ {
+ "PMID": "39715497",
+ "Title": "AIDS (London, England)",
+ "ArticleTitle": "Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes.",
+ "Abstract": "People with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 antireceptor-binding domain (anti-RBD) immunoglobulin G (IgG) geometrical concentrations and neutralizing antibody capacity (nAB) in PWH with and without diabetes mellitus. Anti-RBD IgG and nAB in COVID-19-vaccinated PWH were not associated with diabetes mellitus-status or HbA1c 24\u200amonths after the initial COVID-19 vaccination.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "COVID-19 Vaccines",
+ "Antibodies, Neutralizing",
+ "COVID-19",
+ "Female",
+ "HIV Infections",
+ "Middle Aged",
+ "Antibodies, Viral",
+ "Immunoglobulin G",
+ "SARS-CoV-2",
+ "Immunity, Humoral",
+ "Adult",
+ "Diabetes Mellitus",
+ "Vaccination",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39714194",
+ "Title": "European journal of neurology",
+ "ArticleTitle": "Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus.",
+ "Abstract": "Our study revealed that in patients with AIS and diabetes under 55, higher admission hbA1c was associated with an increased risk of the 1-year primary outcome, while in patients aged over 85, lower HbA1c value (\u22646.0%) may be associated with an increased risk of vascular events. The results of our study suggest the age-stratified, heterogeneous associations between admission HbA1c and 1-year vascular outcomes in patients with AIS and diabetes.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Ischemic Stroke",
+ "Aged, 80 and over",
+ "Glycated Hemoglobin",
+ "Diabetes Mellitus",
+ "Age Factors",
+ "Blood Glucose",
+ "Prospective Studies"
+ ]
+ },
+ {
+ "PMID": "39714134",
+ "Title": "Journal of materials chemistry. B",
+ "ArticleTitle": "A step towards non-invasive diagnosis of diabetes mellitus using ",
+ "Abstract": "The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF-MXene (Ni",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus",
+ "Saliva",
+ "Metal-Organic Frameworks",
+ "Transistors, Electronic",
+ "Glucose",
+ "Electrodes",
+ "Biosensing Techniques",
+ "Electrochemical Techniques",
+ "Nickel",
+ "Particle Size"
+ ]
+ },
+ {
+ "PMID": "39710070",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Health disparities in diabetes treatment: The challenge of G6PD deficiency.",
+ "Abstract": "This research highlights serious gaps in the management of G6PD-deficient patients with diabetes, who suffer from insufficient medication management and higher rates of complications. These findings underscore the need to account for G6PD deficiency in diabetes treatment to ensure equitable and effective healthcare for this vulnerable population.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glucosephosphate Dehydrogenase Deficiency",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Glycated Hemoglobin",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Aged",
+ "Blood Glucose",
+ "Cohort Studies",
+ "Healthcare Disparities",
+ "Diabetes Complications",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39709946",
+ "Title": "Cardiorenal medicine",
+ "ArticleTitle": "The Role of Wnt3a/\u03b2-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications.",
+ "Abstract": "We believe that a thorough comprehension of the molecular connections between diabetes and signaling pathways will eventually lead to improved diabetes management.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Transcription Factor 7-Like 2 Protein",
+ "beta Catenin",
+ "Wnt3A Protein",
+ "Wnt Signaling Pathway",
+ "Diabetic Nephropathies",
+ "Animals",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39709804",
+ "Title": "Vaccine",
+ "ArticleTitle": "Seasonal influenza vaccination coverage and the social determinants of influenza vaccination among people over 50 with diabetes in Europe: Analyzing population-based SHARE data for the 2019-2020 and 2021-2022 influenza seasons.",
+ "Abstract": "Despite the increase, the average European influenza vaccination level remains below the EU target of 75\u00a0%. This study fills an important data gap for the ECDC by providing information on influenza vaccination coverage rates among people over 50 with diabetes. The findings highlight the crucial role of a robust social and healthcare system in promoting vaccination. To improve vaccination rates, the ECDC-funded VENICE network should enhance vaccination knowledge, address socioeconomic disparities by strengthening local programs and funding, and collaborate with various stakeholders to develop regional strategies.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Vaccination Coverage",
+ "Cross-Sectional Studies",
+ "Influenza, Human",
+ "Male",
+ "Influenza Vaccines",
+ "Female",
+ "Europe",
+ "Middle Aged",
+ "Aged",
+ "Diabetes Mellitus",
+ "Seasons",
+ "Vaccination",
+ "Social Determinants of Health",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39709395",
+ "Title": "BMC medical informatics and decision making",
+ "ArticleTitle": "A software tool for applying Bayes' theorem in medical diagnostics.",
+ "Abstract": "The software tool\u00a0enhances the estimation and facilitates the comparison of Bayesian diagnostic measures, which are critical for medical practice. It provides a framework for their uncertainty quantification and assists in understanding and applying Bayes' theorem in medical diagnostics.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Bayes Theorem",
+ "Humans",
+ "Software",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39709343",
+ "Title": "BMC primary care",
+ "ArticleTitle": "The profound impact of COVID-19 on the control and care of diabetic patients: a comprehensive retrospective cohort study.",
+ "Abstract": "The COVID-19 pandemic disrupted healthcare systems globally, and the consequences on health and mortality were not only due to the direct impact of the virus, but also to the modifications in priorities. These interruptions in inconsistent care, had consequences for non-communicable diseases (NCDs) like diabetes. Future strategic plans should be prepared and implemented to manage NCD cases in case of pandemics.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Middle Aged",
+ "Retrospective Studies",
+ "Male",
+ "Adult",
+ "Female",
+ "Aged",
+ "Glycated Hemoglobin",
+ "Diabetes Mellitus",
+ "Aged, 80 and over",
+ "Oman",
+ "Body Mass Index",
+ "Blood Pressure",
+ "Young Adult",
+ "SARS-CoV-2",
+ "Hypertension",
+ "Pandemics"
+ ]
+ },
+ {
+ "PMID": "39707324",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Association of triglyceride-glucose index and diabesity: evidence from a national longitudinal study.",
+ "Abstract": "This national longitudinal study in China provides evidence that a higher TyG index is associated with an increased risk of developing diabesity.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Triglycerides",
+ "Longitudinal Studies",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Blood Glucose",
+ "China",
+ "Aged",
+ "Obesity",
+ "Risk Factors",
+ "Insulin Resistance",
+ "Diabetes Mellitus",
+ "Proportional Hazards Models"
+ ]
+ },
+ {
+ "PMID": "39707271",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Erectile dysfunction and associated factors among patients with diabetes in Public hospitals of Harari region, Eastern Ethiopia: modified poisson regression model.",
+ "Abstract": "More than three-fourths of the participants had erectile dysfunction. Significant factors associated with erectile dysfunction included age 35 years and above, depression, current hat use, and low and medium social support level. The management of erectile dysfunction should be integrated into routine medical care in diabetic follow-up clinics, with special attention for those participants aged 35 years and above, who have depression, currently use Khat, and have low-level social support.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Erectile Dysfunction",
+ "Ethiopia",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Middle Aged",
+ "Hospitals, Public",
+ "Prevalence",
+ "Risk Factors",
+ "Diabetes Mellitus",
+ "Poisson Distribution",
+ "Young Adult",
+ "Diabetes Complications",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39707185",
+ "Title": "Molecular medicine (Cambridge, Mass.)",
+ "ArticleTitle": "Elucidating the role of gut microbiota metabolites in diabetes by employing network pharmacology.",
+ "Abstract": "Gut microbiota metabolites primarily exert their therapeutic effects on diabetes through the IL6, AKT1, and PPARG targets. The mechanisms of gut microbiota metabolites regulating DM might involve signaling pathways such as IL-17 pathways, HIF-1 pathways and VEGF pathways.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Gastrointestinal Microbiome",
+ "Humans",
+ "Diabetes Mellitus",
+ "Protein Interaction Maps",
+ "Network Pharmacology",
+ "Proto-Oncogene Proteins c-akt",
+ "Metabolome",
+ "PPAR gamma",
+ "Signal Transduction",
+ "Metabolomics",
+ "Computational Biology"
+ ]
+ },
+ {
+ "PMID": "39706370",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study.",
+ "Abstract": "The ADA criteria can identify individuals with elevated haemoglobinA1c (HbA1c) levels when the 1-hour plasma glucose (1-h PG) stay within the normal range, while the IDF criteria can identify subjects with impaired insulin sensitivity and secretion when fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and HbA1c values are in the normal range.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Glucose Tolerance Test",
+ "Adult",
+ "Blood Glucose",
+ "Hyperglycemia",
+ "Glycated Hemoglobin",
+ "Insulin Resistance",
+ "China",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 2",
+ "Aged",
+ "Insulin",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39705195",
+ "Title": "The American journal of managed care",
+ "ArticleTitle": "Diabetes, cardiorenal, and metabolic multispecialty practice recommendations and early intensive management of cardio-renal-metabolic disease.",
+ "Abstract": "In recent years, evidence has continued to mount showing a strong relationship between diabetes, cardiovascular disease, and chronic kidney disease. This, in turn, has driven a shift to a more integrated and holistic approach in the treatment of patients with cardio-renal-metabolic (CRM) disease. The 2022 Diabetes, Cardiorenal, and Metabolic (DCRM) multispecialty practice recommendations were the first multispecialty consensus on the comprehensive management of patients with diabetes, cardiorenal, and/or metabolic diseases, providing evidence-based recommendations that are simple to implement. The recommendations provide guidance on assessments and treatments, including both lifestyle therapy and pharmacotherapy, for patients across the DCRM spectrum, and are an invaluable tool for clinicians who need to develop treatment plans for complex patients with cardio-renal-metabolic disease. This article reviews the key elements of the DCRM recommendations and summarizes the updates included in the DCRM 2.0.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardio-Renal Syndrome",
+ "Diabetes Mellitus",
+ "Metabolic Diseases",
+ "Practice Guidelines as Topic",
+ "Renal Insufficiency, Chronic"
+ ]
+ },
+ {
+ "PMID": "39703865",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Association of serum uric acid to high-density lipoprotein cholesterol ratio with all-cause and cardiovascular mortality in patients with diabetes or prediabetes: a prospective cohort study.",
+ "Abstract": "Higher UHR was correlated with increased all-cause and cardiovascular mortality in patients with diabetes or prediabetes.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Prediabetic State",
+ "Uric Acid",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Cholesterol, HDL",
+ "Prospective Studies",
+ "Adult",
+ "Biomarkers",
+ "Diabetes Mellitus",
+ "Prognosis",
+ "Aged",
+ "Nutrition Surveys",
+ "Cohort Studies",
+ "Follow-Up Studies",
+ "Cause of Death",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39703057",
+ "Title": "Journal of helminthology",
+ "ArticleTitle": "Association of ",
+ "Abstract": "Previous studies have shown that helminth infection protects against the development of diabetes mellitus (DM), possibly related to the hygiene hypothesis. However, studies involving ",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Strongyloides stercoralis",
+ "Strongyloidiasis",
+ "Animals",
+ "Humans",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39702258",
+ "Title": "BMC research notes",
+ "ArticleTitle": "Comparison of nasopharyngeal bacteriological profile between patients with diabetes and healthy individuals in Accra, Ghana.",
+ "Abstract": "The nasopharyngeal bacterial flora of PLWD in Accra seems to have comparable diversities with those of non-diabetics. Nonetheless, the PLWD had a higher carriage rate of Acinetobacter baumannii but seem to have some protection against carriage of Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nasopharynx",
+ "Male",
+ "Female",
+ "Case-Control Studies",
+ "Adult",
+ "Middle Aged",
+ "Ghana",
+ "Diabetes Mellitus",
+ "Aged",
+ "Bacteria",
+ "Young Adult",
+ "Respiratory Tract Infections"
+ ]
+ },
+ {
+ "PMID": "39702047",
+ "Title": "BMC public health",
+ "ArticleTitle": "Exploring mHealth app utilization for diabetes self-management: survey insights from a northern district in Malaysia.",
+ "Abstract": "The findings highlight the underutilization of mHealth apps for diabetes management despite their perceived usefulness. Challenges faced by users and non-users underscore the need for more awareness, thus encourage widespread acceptance and usage of mHealth apps in diabetes care.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Malaysia",
+ "Male",
+ "Mobile Applications",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Telemedicine",
+ "Self-Management",
+ "Surveys and Questionnaires",
+ "Diabetes Mellitus",
+ "Aged",
+ "Diabetes Mellitus, Type 2",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39700129",
+ "Title": "PloS one",
+ "ArticleTitle": "Sociodemographic factors, clinical characteristics, outcomes and short-term follow-up in COVID-19 patients with new onset hyperglycemia and pre-existing diabetes on admission in a tertiary-care hospital in Bangladesh.",
+ "Abstract": "In conclusion, our investigation illuminates the clinical trajectory of new-onset hyperglycemia in the context of COVID-19 and reinforces the necessity for diligent monitoring and management post-discharge. Therefore, close monitoring and follow-up of COVID-19 patients is recommended for the early detection and management of hyperglycemia and the prevention of diabetes development in the long run.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Male",
+ "Female",
+ "Bangladesh",
+ "Hyperglycemia",
+ "Middle Aged",
+ "Tertiary Care Centers",
+ "Diabetes Mellitus",
+ "Prospective Studies",
+ "Adult",
+ "Follow-Up Studies",
+ "Aged",
+ "SARS-CoV-2",
+ "Hospitalization",
+ "Patient Discharge",
+ "Risk Factors",
+ "Socioeconomic Factors",
+ "Hospital Mortality"
+ ]
+ },
+ {
+ "PMID": "39699704",
+ "Title": "Current atherosclerosis reports",
+ "ArticleTitle": "Statin Use and Hyperglycemia: Do Statins Cause Diabetes?",
+ "Abstract": "Since initial reporting of statin-induced hyperglycemia and NODM, the totality of available data corroborates an association between incident diabetes and statin use. A consensus that high-intensity statin and individuals with obesity or glycemic parameters approximating diabetes thresholds constitute the majority of risk exists. Alterations in insulin signaling, glucose transport and gastrointestinal microbiota are leading hypotheses underlying the mechanisms of statin-induced hyperglycemia. The probability of NODM based on an individual's risk factors and statin specific properties can be anticipated. This risk needs to be contextualized with the risk of ASCVD. In order to effectively adjudicate the risk of NODM, improvement in formulating and ultimately conveying a comprehensive ASCVD risk assessment to patients is necessary.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
+ "Hyperglycemia",
+ "Diabetes Mellitus",
+ "Risk Factors",
+ "Atherosclerosis",
+ "Blood Glucose"
+ ]
+ },
+ {
+ "PMID": "39699431",
+ "Title": "Revista gaucha de enfermagem",
+ "ArticleTitle": "Educational technologies to promote the quality of life of people with diabetes: quasi-experimental study.",
+ "Abstract": "the use of educational technologies in educational interventions demonstrated an improvement in the quality of life of people living with diabetes.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Quality of Life",
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Diabetes Mellitus",
+ "Patient Education as Topic",
+ "Educational Technology",
+ "Adult",
+ "Aged",
+ "Surveys and Questionnaires",
+ "Controlled Before-After Studies"
+ ]
+ },
+ {
+ "PMID": "39698032",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Non-linear dose-response relationship between the visceral adiposity index and diabetes in adults with normoglycemia: a cohort study.",
+ "Abstract": "Our cohort study validated the positive and non-linear relationship between the VAI and diabetes in normoglycemic adults in Japan. The relevance was more marked in women than in men. For those with a VAI below 4.67, a further reduction in the VAI could potentially lead to a significant decrease in diabetes risk.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Intra-Abdominal Fat",
+ "Japan",
+ "Cohort Studies",
+ "Obesity, Abdominal",
+ "Adiposity",
+ "Diabetes Mellitus",
+ "Risk Factors",
+ "Blood Glucose",
+ "Longitudinal Studies",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39696515",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "Gender differences in the association between the uric acid to high-density lipoprotein cholesterol ratio and diabetes risk: a mediation analysis of c-reactive protein, triglycerides, and insulin resistance.",
+ "Abstract": "This study demonstrates that the association between UHR and diabetes risk exhibits gender differences, with higher diabetes risk observed in women, while men show stronger mediation effects in insulin resistance, lipid metabolism, and inflammatory response.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Uric Acid",
+ "C-Reactive Protein",
+ "Male",
+ "Female",
+ "Insulin Resistance",
+ "Triglycerides",
+ "Cholesterol, HDL",
+ "Adult",
+ "Middle Aged",
+ "Risk Factors",
+ "Sex Factors",
+ "Diabetes Mellitus",
+ "Mediation Analysis",
+ "Biomarkers",
+ "Sex Characteristics"
+ ]
+ },
+ {
+ "PMID": "39696157",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Identify unmet needs in diabetes care in Shandong, China: a secondary analysis of a cross-sectional study using cascade of care framework.",
+ "Abstract": "A significant unmet need exists for diabetes adults from screening to management, particularly the comprehensive management of glycemia, BP and LDL-c levels among those with multimorbidity. Tailored strategies and appropriate allocation of healthcare resource is needed to addressing gaps in care continuum and reduce long-term disease burden.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cross-Sectional Studies",
+ "China",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Health Services Needs and Demand",
+ "Diabetes Mellitus",
+ "Young Adult",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 2",
+ "Mass Screening",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39696101",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Assessment of sex disparities in prevalence of diagnosed and undiagnosed diabetes mellitus: results from the Bangladesh demographic and health survey data.",
+ "Abstract": "This study reveals that diabetes prevalence in Bangladesh is influenced by various risk factors, with distinct impacts on men and women. Women living in Dhaka who are unemployed are at a significantly higher risk of both diagnosed and undiagnosed diabetes compared to men. To effectively combat the rising diabetes rate, we must implement targeted interventions that address these sex-specific disparities. These interventions should focus on age, wealth, regional variations, and especially on unemployed women in Dhaka, considering their heightened risk.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Bangladesh",
+ "Adult",
+ "Prevalence",
+ "Diabetes Mellitus",
+ "Middle Aged",
+ "Health Surveys",
+ "Young Adult",
+ "Risk Factors",
+ "Sex Factors",
+ "Undiagnosed Diseases",
+ "Adolescent",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39695649",
+ "Title": "BMC medical informatics and decision making",
+ "ArticleTitle": "An explainable analysis of diabetes mellitus using statistical and artificial intelligence techniques.",
+ "Abstract": "An integrated analysis of DM using a variety of methodologies is critical for timely detection of the disease and informed clinical decision-making.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Artificial Intelligence",
+ "Diabetes Mellitus",
+ "Neural Networks, Computer",
+ "Middle Aged",
+ "Female",
+ "Male",
+ "Models, Statistical",
+ "Support Vector Machine",
+ "Adult",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39695632",
+ "Title": "BMC health services research",
+ "ArticleTitle": "Barriers and facilitators in the acquisition of diabetes knowledge among tertiary-care nurses in central and southern Malawi: an exploratory-descriptive qualitative study.",
+ "Abstract": "The study brings to light various challenges and opportunities in the acquisition of diabetes knowledge among tertiary-care nurses in Malawi. Given our study results, we believe that cost-effective measures can be utilised to address the barriers to the acquisition of diabetes knowledge among nurses. This is a crucial step towards ensuring that nurses are knowledgeable and competent in the provision of care for patients with diabetes in low-resource countries.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Malawi",
+ "Qualitative Research",
+ "Female",
+ "Diabetes Mellitus",
+ "Focus Groups",
+ "Health Knowledge, Attitudes, Practice",
+ "Adult",
+ "Male",
+ "Nursing Staff, Hospital",
+ "Tertiary Care Centers",
+ "Clinical Competence",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39695379",
+ "Title": "BMC medical research methodology",
+ "ArticleTitle": "Robustness assessment of regressions using cluster analysis typologies: a bootstrap procedure with application in state sequence analysis.",
+ "Abstract": "Investigating the relationship between trajectory patterns and covariates is of interest in many situations. However, it is a challenging task with potential pitfalls. Our Robustness Assessment of Regression using Cluster Analysis Typologies (RARCAT) may assist in ensuring the robustness of such association studies. The method is applicable wherever clustering is combined with regression analysis, so its relevance goes beyond State Sequence Analysis.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cluster Analysis",
+ "Regression Analysis",
+ "Models, Statistical",
+ "Algorithms",
+ "Diabetes Mellitus",
+ "Data Interpretation, Statistical"
+ ]
+ },
+ {
+ "PMID": "39693799",
+ "Title": "Psychiatry research",
+ "ArticleTitle": "Association between triglyceride-glucose (TyG) index and the incidence of depression in US adults with diabetes or pre-diabetes.",
+ "Abstract": "There is a linear positive association between the TyG index and the incidence of depression in populations with diabetes or pre-diabetes.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Prediabetic State",
+ "Incidence",
+ "Middle Aged",
+ "Depression",
+ "Triglycerides",
+ "United States",
+ "Adult",
+ "Blood Glucose",
+ "Nutrition Surveys",
+ "Diabetes Mellitus",
+ "Aged",
+ "Insulin Resistance"
+ ]
+ },
+ {
+ "PMID": "39693267",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Glycemic Management and Individualized Diabetes Care in Dialysis-Dependent Kidney Failure.",
+ "Abstract": "Of the nearly 600,000 people in the U.S. who receive dialysis for chronic kidney failure, >60% have diabetes. People receiving dialysis who have diabetes have worse overall and cardiovascular survival rates than those without diabetes. Diabetes care in the dialysis setting is complicated by kidney failure-related factors that render extrapolation of glycated hemoglobin (HbA1c) targets to the dialysis population unreliable and may change the risk-benefit profiles of glucose-lowering and disease-modifying therapies. No prospective studies have established the optimal glycemic targets in the dialysis population, and few randomized clinical trials of glucose-lowering medications included individuals receiving dialysis. Observational data suggest that both lower and higher HbA1c are associated with mortality in the dialysis population. Existing data suggest the potential for safety and effectiveness of some glucose-lowering medications in the dialysis population, but firm conclusions are hindered by limitations in study design and sample size. While population-specific knowledge gaps about optimal glycemic targets and diabetes medication safety and effectiveness preclude the extension of all general population diabetes guidelines to the dialysis-dependent diabetes population, these uncertainties should not detract from the importance of providing person-centered diabetes care to people receiving dialysis. Diabetes care for individuals with and without dialysis-dependent kidney failure should be holistic, based on individual preferences and prognoses, and tailored to integrate established treatment approaches with proven benefits for glycemic control and cardiovascular risk reduction. Additional research is needed to inform how recent pharmacologic and technological advances can be applied to support such individualized care for people receiving maintenance dialysis.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Renal Dialysis",
+ "Kidney Failure, Chronic",
+ "Glycated Hemoglobin",
+ "Diabetes Mellitus",
+ "Blood Glucose",
+ "Precision Medicine",
+ "Hypoglycemic Agents",
+ "Glycemic Control"
+ ]
+ },
+ {
+ "PMID": "39692388",
+ "Title": "The Israel Medical Association journal : IMAJ",
+ "ArticleTitle": "Ethnic Disparities in Chronic Diseases: Comparison Between Arabs and Jews in Israel.",
+ "Abstract": "Significant differences were found in the prevalence of chronic diseases among Arab and Jewish patients in Israel. Culturally relevant interventions are crucial for disease prevention, early diagnosis, and management of chronic diseases among different ethnic groups.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Adult",
+ "Aged",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Young Adult",
+ "Arabs",
+ "Chronic Disease",
+ "Diabetes Mellitus",
+ "Health Status Disparities",
+ "Israel",
+ "Jews",
+ "Obesity",
+ "Prevalence",
+ "Retrospective Studies"
+ ]
+ },
+ {
+ "PMID": "39686708",
+ "Title": "Biometrical journal. Biometrische Zeitschrift",
+ "ArticleTitle": "Assessing Balance of Baseline Time-Dependent Covariates via the Fr\u00e9chet Distance.",
+ "Abstract": "Assessment of covariate balance is a key step when performing comparisons between groups particularly in real-world data. We generally evaluate it on baseline covariates, but rarely on longitudinal ones prior to a management decision. We could use pointwise standardized mean differences, standardized differences of slopes, or weights from the model for such purpose. Pointwise differences could be cumbersome for densely sampled longitudinal markers and/or measured at different points. Slopes are suitable for linear or transformable models but not for more complex curves. Weights do not identify the specific covariate(s) responsible for imbalances. This work presents the Fr\u00e9chet distance as a viable alternative to assess balance of time-dependent covariates. A set of linear and nonlinear curves for which their standardized difference or differences in functional parameters were within 10% sought to identify the Fr\u00e9chet distance equivalent to this threshold. This threshold is dependent on the level of noise present and thus within group heterogeneity and error variance are needed for its interpretation. Applied to a set of real curves representing the monthly trajectory of hemoglobin A1c from diabetic patients showed that the curves in the two groups were not balanced at the 10% mark. A Beta distribution represents the Fr\u00e9chet distance distribution reasonably well in most scenarios. This assessment of covariate balance provides the following advantages: It can handle curves of different lengths, shapes, and arbitrary time points. Future work includes examining the utility of this measure under within-series missingness, within-group heterogeneity, its comparison with other approaches, and asymptotics.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glycated Hemoglobin",
+ "Time Factors",
+ "Biometry",
+ "Models, Statistical",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39686687",
+ "Title": "Alimentary pharmacology & therapeutics",
+ "ArticleTitle": "Risk-Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome.",
+ "Abstract": "People with diabetes or metabolic syndrome reach risk levels comparable to the average risk population three to four years earlier. Our results offer empirical guidance for defining risk-adapted starting ages of CRC screening for these high-risk groups.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Colorectal Neoplasms",
+ "Metabolic Syndrome",
+ "Middle Aged",
+ "Early Detection of Cancer",
+ "Male",
+ "Europe",
+ "Female",
+ "Adult",
+ "Diabetes Mellitus",
+ "North America",
+ "Age Factors",
+ "Risk Factors",
+ "Mass Screening",
+ "Risk Assessment"
+ ]
+ },
+ {
+ "PMID": "39684919",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "The Emerging Role of p21 in Diabetes and Related Metabolic Disorders.",
+ "Abstract": "In the context of cell cycle inhibition, anti-proliferation, and the dysregulation observed in certain cancer pathologies, the protein p21 assumes a pivotal role. p21 links DNA damage responses to cellular processes such as apoptosis, senescence, and cell cycle arrest, primarily functioning as a regulator of the cell cycle. However, accumulating empirical evidence suggests that p21 is both directly and indirectly linked to a number of different metabolic processes. Intriguingly, recent investigations indicate that p21 significantly contributes to the pathogenesis of diabetes. In this review, we present a comprehensive evaluation of the scientific literature regarding the involvement of p21 in metabolic processes, diabetes etiology, pancreatic function, glucose homeostasis, and insulin resistance. Furthermore, we provide an encapsulated overview of therapies that target p21 to alleviate metabolic disorders. A deeper understanding of the complex interrelationship between p21 and diabetes holds promise for informing current and future therapeutic strategies to address this rapidly escalating health crisis.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cyclin-Dependent Kinase Inhibitor p21",
+ "Diabetes Mellitus",
+ "Animals",
+ "Metabolic Diseases",
+ "Insulin Resistance",
+ "DNA Damage"
+ ]
+ },
+ {
+ "PMID": "39684905",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues.",
+ "Abstract": "Like humans, cats have a strong relationship between decreasing insulin sensitivity and the development of diabetes with obesity. However, the underlying molecular mechanisms of impaired insulin secretion and signaling in cats remain largely unknown. A total of 54 client-owned nondiabetic lean (",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Cats",
+ "Insulin",
+ "Signal Transduction",
+ "Muscle, Skeletal",
+ "Biomarkers",
+ "Liver",
+ "Cat Diseases",
+ "Male",
+ "Pancreas",
+ "Diabetes Mellitus",
+ "Receptor, Insulin",
+ "Female",
+ "Insulin Resistance",
+ "Insulin Receptor Substrate Proteins",
+ "Glucagon-Like Peptide 1",
+ "Incretins"
+ ]
+ },
+ {
+ "PMID": "39684868",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases.",
+ "Abstract": "Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people's lives and health. To date, therapeutics with high therapeutic efficacy and low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatment. Here, we first introduce the diversity of nanomaterials and the effects of their different physicochemical properties on pancreatic function. Following this, we analyze the potential of nanomaterials to enhance pancreatic targeting by overcoming the challenges of traditional delivery methods through surface modifications, structural adjustments, and optimized drug loading. Then, we introduce the application of structurally optimized nanomaterials to pancreatic-related diseases. For instance, on pancreatic cancer (as drug delivery platforms, for the promotion of radiation therapy, and as multifunctional tools), pancreatitis (as drug delivery systems, anti-inflammatory and anti-fibrotic agents), and diabetes (as insulin delivery carriers, for protecting pancreatic \u03b2 cells, and for improving insulin resistance). Through analysis of the progress of current research, we summarize how nanomaterials can enhance treatment efficacy while minimizing side effects. Finally, we look forward to the prospects of nanomaterials in pancreatic disease treatment.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nanostructures",
+ "Pancreatic Diseases",
+ "Animals",
+ "Drug Delivery Systems",
+ "Pancreatic Neoplasms",
+ "Diabetes Mellitus",
+ "Drug Carriers",
+ "Pancreas"
+ ]
+ },
+ {
+ "PMID": "39684468",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Multifaceted Role of Apolipoprotein C3 in Cardiovascular Disease Risk and Metabolic Disorder in Diabetes.",
+ "Abstract": "Apolipoprotein C3 (APOC3) plays a critical role in regulating triglyceride levels and serves as a key predictor of cardiovascular disease (CVD) risk, particularly in patients with diabetes. While APOC3 is known to inhibit lipoprotein lipase, recent findings reveal its broader influence across lipoprotein metabolism, where it modulates the structure and function of various lipoproteins. Therefore, this review examines the complex metabolic cycle of APOC3, emphasizing the impact of APOC3-containing lipoproteins on human metabolism, particularly in patients with diabetes. Notably, APOC3 affects triglyceride-rich lipoproteins and causes structural changes in high-, very low-, intermediate-, and low-density lipoproteins, thereby increasing CVD risk. Evidence suggests that elevated APOC3 levels-above the proposed safe range of 10-15 mg/dL-correlate with clinically significant CVD outcomes. Recognizing APOC3 as a promising biomarker for CVD, this review underscores the urgent need for high-throughput, clinically feasible methods to further investigate its role in lipoprotein physiology in both animal models and human studies. Additionally, we analyze the relationship between APOC3-related genes and lipoproteins, reinforcing the value of large-population studies to understand the impact of APOC3 on metabolic diseases. Ultimately, this review supports the development of therapeutic strategies targeting APOC3 reduction as a preventive approach for diabetes-related CVD.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Apolipoprotein C-III",
+ "Cardiovascular Diseases",
+ "Animals",
+ "Diabetes Mellitus",
+ "Metabolic Diseases",
+ "Lipoproteins",
+ "Triglycerides",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39684379",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Increased Leptin Levels in Plasma and Serum in Patients with Metabolic Disorders: A Systematic Review and Meta-Analysis.",
+ "Abstract": "A large number of studies have reported the relationships between leptin levels and diabetes or obesity. However, the results are still controversial, and no consensus has been reached. Therefore, the purpose of the study was to collect data from various databases to perform a meta-analysis and address the inconsistencies in these studies. A systematic literature search was conducted on PubMed, Web of Science, and EBSCO for relevant available articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association by a meta-analysis. Fifteen reports with 1,388 cases and 3,536 controls were chosen for the meta-analysis. First, an increase in leptin levels in serum (SMD 0.69; 95% CI 0.36-1.02 ng/mL) and plasma (SMD 0.46; 95% CI 0.18-0.74 ng/mL) was observed in individuals with diabetes compared to controls. This increased level was also observed by gender and population. Second, statistical analysis showed that leptin levels in serum were significantly increased in individuals with obesity (SMD 1.03; 95% CI 0.72-1.34 ng/mL). This meta-analysis analyzed leptin in individuals with diabetes or obesity and emphasized the importance of monitoring serum/plasma leptin levels in patients with these diseases. However, more comprehensive studies are necessary in order to draw firm conclusions.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Leptin",
+ "Humans",
+ "Obesity",
+ "Metabolic Diseases",
+ "Diabetes Mellitus",
+ "Female",
+ "Male",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39684343",
+ "Title": "International journal of molecular sciences",
+ "ArticleTitle": "Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis.",
+ "Abstract": "Major depressive disorder (MDD) and diabetes mellitus (DM) remain among the most prevalent diseases and the most significant challenges faced by medicine in the 21st century. The frequent co-occurrence and bidirectional relationship between the two conditions necessitates the identification of treatment strategies that benefit both. The purpose of this study was to systematically review and meta-analyze data on the efficacy and safety of agomelatine (AGO) in the treatment of patients with depression with comorbid diabetes to explore its potential mechanism of action in both diseases and its impact on diabetic parameters. Following PRISMA guidelines, a total of 11 studies were identified, both preclinical and clinical trials. Agomelatine has shown great potential as a treatment option for patients with diabetes and comorbid depression and anxiety. In addition to improving depressive and anxiety symptoms, it is also beneficial in glycemic control. A meta-analysis demonstrated a statistically significant reduction in glycated hemoglobin (HbA1C) and fasting blood glucose (FBG) levels following AGO administration over a period of 8-16 weeks. The administration of agomelatine was found to result in a significantly greater reduction in HbA1C than that observed with the selective serotonin reuptake inhibitor (SSRI) medications (namely fluoxetine, sertraline, and paroxetine) during 12-16 weeks of therapy. Furthermore, AGO has been found to be at least as effective as SSRIs in reducing depressive symptoms and more effective than SSRIs in reducing anxiety symptoms. The safety of such treatment is similar to SSRIs; no severe adverse events were reported, and the incidence of some side effects, such as insomnia and sexual dysfunction, are even less often reported. Particularly promising is also its potential action in improving some diabetic complications reported in preclinical trials. This might be through mechanisms involving the reduction in oxidative stress, anti-inflammatory effects, and potentially noradrenergic or NMDA receptor modulation. Further clinical studies on larger sample sizes, as well as elucidating its mechanisms of action, especially in the context of diabetic complications, are needed. Research should also focus on identifying the patient subpopulations most likely to benefit from agomelatine treatment.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Acetamides",
+ "Diabetes Mellitus",
+ "Depression",
+ "Antidepressive Agents",
+ "Depressive Disorder, Major",
+ "Blood Glucose",
+ "Glycated Hemoglobin",
+ "Treatment Outcome",
+ "Naphthalenes"
+ ]
+ },
+ {
+ "PMID": "39683638",
+ "Title": "Nutrients",
+ "ArticleTitle": "High Meat Intake and Ferritin Levels in Relation to Cardiovascular Risk Among Individuals with Diabetes in Mongolia.",
+ "Abstract": "In this diabetic Mongolian population, high meat intake was associated with elevated ferritin levels, which may have reflected dietary iron intake rather than systemic inflammation or increased CVD risk.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Ferritins",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Mongolia",
+ "Cross-Sectional Studies",
+ "Cardiovascular Diseases",
+ "Meat",
+ "Diet",
+ "Heart Disease Risk Factors",
+ "Adult",
+ "Biomarkers",
+ "Aged",
+ "Diabetes Mellitus",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39683480",
+ "Title": "Nutrients",
+ "ArticleTitle": "Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults.",
+ "Abstract": "Findings of the present study indicate that the dietary intake of PUFAs was cross-sectionally, inversely, and significantly associated with blood glucose levels and the prevalence of diabetes in a large sample of Italian community-dwelling older adults.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Blood Glucose",
+ "Independent Living",
+ "Italy",
+ "Fatty Acids, Unsaturated",
+ "Diabetes Mellitus",
+ "Aged, 80 and over",
+ "Diet",
+ "Blood Pressure",
+ "Cardiometabolic Risk Factors",
+ "Fatty Acids, Omega-3",
+ "Body Mass Index"
+ ]
+ },
+ {
+ "PMID": "39683416",
+ "Title": "Nutrients",
+ "ArticleTitle": "Trends and Motivations in Dietary Supplement Use Among People with Diabetes: A Population-Based Analysis Using National Health and Nutrition Examination Survey Data from the 2009-2020 Period.",
+ "Abstract": "Dietary supplement use is prevalent among people with diabetes, and most diabetic supplement use is self-directed, which reflects a growing trend toward complementary therapies. Healthcare providers are encouraged to inquire about patients' use of supplements and offer appropriate guidance as an integral component of comprehensive diabetes management.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Dietary Supplements",
+ "Female",
+ "Nutrition Surveys",
+ "Male",
+ "Middle Aged",
+ "Adult",
+ "United States",
+ "Diabetes Mellitus",
+ "Motivation",
+ "Aged",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39681993",
+ "Title": "Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association",
+ "ArticleTitle": "Hepatic parenchymal hypoattenuation in dogs with diabetes mellitus on computed tomography consistent with hepatic steatosis.",
+ "Abstract": "Hypoattenuation of the liver, consistent with hepatic steatosis or lipidosis, has been reported in veterinary patients. In people, measuring CT hepatic attenuation is diagnostic for hepatic steatosis, and hypoattenuation of the liver is defined as absolute if less than 40\u00a0HU or relative if the liver is 10\u00a0HU less than the spleen. The purpose of this study is to describe hepatic parenchymal attenuation in dogs with diabetes mellitus with or without diabetic ketosis (DK) or diabetic ketoacidosis (DKA), using the above categorization for absolute and relative hypoattenuation, as with humans. We hypothesized dogs with DK or DKA were more likely to have hypoattenuating livers. Twenty-seven diabetic dogs were included; fifteen were categorized in Group 1 as without DK or DKA, six in Group 2 as DK, and six in Group 3 as DKA. In Group 3, four of six dogs had absolute and relative hypoattenuating livers. Three of these were visually hypoattenuating to the vasculature, with one having negative attenuation and a histopathologic diagnosis of severe hepatic lipidosis. In Group 2, four of six dogs had relative hypoattenuating livers. In Group 1, only one of 15 dogs had a relatively hypoattenuating liver. Groups 2 and 3 had significantly lower absolute liver attenuation than Group 1. Presumed hepatic steatosis was present on CT and was more common with DK or DKA. These findings may help provide hepatic sampling recommendations and alter patient prognosis. Further research is needed to establish absolute and relative liver attenuation in dogs with correlation to histopathology and patient outcome.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Dogs",
+ "Dog Diseases",
+ "Fatty Liver",
+ "Tomography, X-Ray Computed",
+ "Male",
+ "Liver",
+ "Female",
+ "Diabetic Ketoacidosis",
+ "Diabetes Mellitus",
+ "Retrospective Studies"
+ ]
+ },
+ {
+ "PMID": "39681831",
+ "Title": "Cardiovascular & hematological disorders drug targets",
+ "ArticleTitle": "A Comprehensive Review of Fear of Eating Behaviour in Individuals with Diabetes: Exploring Therapeutic Interventions for Diabulimia.",
+ "Abstract": "A multidisciplinary strategy combining healthcare specialists specializing in diabetes management, mental health, and nutrition is required for effective therapy of fear of eating behaviour in diabetes. Cognitive-behavioral therapy and mindfulness-based therapies, as well as psychological support, have shown potential in reducing the fear of eating habits. This analysis gives significant information for healthcare providers to help patients with diabetes who are afraid of eating and urges additional research on the topic.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Fear",
+ "Feeding Behavior",
+ "Diabetes Mellitus",
+ "Cognitive Behavioral Therapy",
+ "Feeding and Eating Disorders"
+ ]
+ },
+ {
+ "PMID": "39681614",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Nerve ultrasound helps to distinguish CIDP patients with diabetes from patients with diabetic polyneuropathy.",
+ "Abstract": "Diabetic polyneuropathy (DPN) shares overlapping clinical and electrodiagnostic features with chronic inflammatory demyelinating polyneuropathy (CIDP), which complicates the differential diagnosis of CIDP in diabetic patients. 32 patients with diabetes mellitus and CIDP, 68 patients with CIDP without diabetes, 83 patients with DPN, and 28 diabetic patients without polyneuropathy were examined using clinical scores (Overall Neuropathy Limitation Scale (ONLS), Neuropathy Symptom Score, Neuropathy Deficit Score), nerve conduction studies, and nerve ultrasound (Ultrasound Pattern Sum Score (UPSS)). The ONLS was significantly higher in the CIDP patients with diabetes than in DPN (median [interquartile range]: 4.0 [3.0] vs. 0 [1.0], p\u2009<\u20090.001) as well as the UPSS (4.0 [6.0] vs. 0 [2.9], p\u2009<\u20090.001). Multiple binary logistic regression revealed UPSS and ONLS as statistically significant predictors to differentiate between CIDP with diabetes and DPN. Receiver operating characteristic curve analysis showed the ONLS with an area under the curve (AUC) of 0.918 (95% CI: 0.868-0.0.967, p\u2009<\u20090.001). The UPSS total score had an AUC of 0.826 (95% CI: 0.743-0.909, p\u2009<\u20090.001). An UPSS\u2009\u2265\u20092.5 had a sensitivity of 77.4% and a specificity of 68.7% to detect CIDP. An ONLS\u2009\u2265\u20091.5 had a sensitivity of 87.1% and a specificity of 81.9% to detect CIDP. ROC curve analysis of a composite score of ONLS and UPSS revealed an AUC of 0.959 (95% CI: 0.928-0.991, p\u2009<\u20090.001). CIDP is an important differential diagnosis in people with diabetes mellitus. This study reports that the UPSS is well suited to differentiate between DPN and CIDP.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Polyradiculoneuropathy, Chronic Inflammatory Demyelinating",
+ "Male",
+ "Diabetic Neuropathies",
+ "Female",
+ "Middle Aged",
+ "Ultrasonography",
+ "Diagnosis, Differential",
+ "Aged",
+ "Neural Conduction",
+ "ROC Curve",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39681186",
+ "Title": "Preventive medicine",
+ "ArticleTitle": "Trends in modifiable risk factors for dementia among midlife adults in the United States: The National Health and nutrition examination survey 1999-2018.",
+ "Abstract": "The prevalence of diabetes and obesity increased in this large, nationally representative U.S. study population, while the prevalence of smoking decreased. More effective public health interventions are needed to mitigate the impact of these risk factors and ultimately reduce the burden of dementia in aging populations.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Risk Factors",
+ "Nutrition Surveys",
+ "United States",
+ "Dementia",
+ "Adult",
+ "Prevalence",
+ "Diabetes Mellitus",
+ "Obesity",
+ "Smoking",
+ "Hypertension",
+ "Alcohol Drinking"
+ ]
+ },
+ {
+ "PMID": "39680279",
+ "Title": "Lifetime data analysis",
+ "ArticleTitle": "Proportional rates model for recurrent event data with intermittent gaps and a terminal event.",
+ "Abstract": "Recurrent events are common in medical practice or epidemiologic studies when each subject experiences a particular event repeatedly over time. In some long-term observations of recurrent events, a terminal event such as death may exist in recurrent event data. Meanwhile, some inspected subjects will withdraw from a study for some time for various reasons and then resume, which may happen more than once. The period between the subject leaving and returning to the study is called an intermittent gap. One naive method typically ignores gaps and treats the events as usual recurrent events, which could result in misleading estimation results. In this article, we consider a semiparametric proportional rates model for recurrent event data with intermittent gaps and a terminal event. An estimation procedure is developed for the model parameters, and the asymptotic properties of the resulting estimators are established. Simulation studies demonstrate that the proposed estimators perform satisfactorily compared to the naive method that ignores gaps. A diabetes study further shows the utility of the proposed method.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Recurrence",
+ "Computer Simulation",
+ "Models, Statistical",
+ "Proportional Hazards Models",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39680083",
+ "Title": "International orthopaedics",
+ "ArticleTitle": "Hydrodilatation: a comparison between diabetics and non-diabetics with adhesive capsulitis.",
+ "Abstract": "Hydrodilatation is an effective treatment option in the short and medium term in both diabetics and non-diabetics with adhesive capsulitis, with good relief of pain and improvement in shoulder range of motion. Diabetic patients have significantly less improvement in range of motion and pain compared to non-diabetics at six months post hydrodilatation.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bursitis",
+ "Male",
+ "Female",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Aged",
+ "Dilatation",
+ "Range of Motion, Articular",
+ "Shoulder Joint",
+ "Treatment Outcome",
+ "Pain Measurement",
+ "Adult",
+ "Diabetes Mellitus",
+ "Diabetes Complications"
+ ]
+ },
+ {
+ "PMID": "39678201",
+ "Title": "Annals of global health",
+ "ArticleTitle": "Association between Food Insecurity, Socioeconomic Status of the Household Head, and Hypertension and Diabetes in Maputo City.",
+ "Abstract": {
+ "i": "Conclusions:"
+ },
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hypertension",
+ "Food Insecurity",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Middle Aged",
+ "Diabetes Mellitus",
+ "Adult",
+ "Social Class",
+ "Family Characteristics",
+ "Aged",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39676179",
+ "Title": "The Journal of the Association of Physicians of India",
+ "ArticleTitle": "Empowering Physicians for Holistic Wellness in Diabetes Management through Mind-Body Medicine: Implications of the Psycho-Neuro-Immuno-Endocrine/Enteric Concept in Diabetes.",
+ "Abstract": "The psycho-neuro-immuno-endocrine/enteric (PNIE) axis is a fundamental concept in neuroscience, integral to the neuroendocrine system (NES). It encompasses the interactions between behavior, neurology, endocrinology, gut biology, and the immune system. These interactions regulate crucial metabolic processes like glucose, lipid, and protein metabolism, blood pressure, and various homeostatic functions, including blood pressure regulation, thermogenesis and pulmonary hypoxia detection.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Holistic Health",
+ "Mind-Body Therapies",
+ "Diabetes Mellitus",
+ "Neurosecretory Systems"
+ ]
+ },
+ {
+ "PMID": "39675484",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes.",
+ "Abstract": "Our research indicates that among US adults with diabetes or prediabetes, BRI exhibits a U-shaped relationship with all-cause and cardiovascular mortality, with threshold values of 5.54 and 5.21, respectively.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Prediabetic State",
+ "Male",
+ "Female",
+ "Cardiovascular Diseases",
+ "Middle Aged",
+ "Diabetes Mellitus",
+ "Nutrition Surveys",
+ "Adult",
+ "Aged",
+ "Body Mass Index",
+ "Cause of Death",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39674445",
+ "Title": "Chemico-biological interactions",
+ "ArticleTitle": "Host-microbiota interplay in arsenic metabolism: Implications on host glucose homeostasis.",
+ "Abstract": "Arsenic (As), a naturally occurring element with unique properties, has been recognized as the largest mass poisoning in the world by the World Health Organization (WHO). Approximately 200 million people worldwide are exposed to toxic levels of arsenic due to natural and anthropogenic activities. This widespread exposure necessitates a deeper understanding of microbe-arsenic interactions and their potential influence on host exposure and health risks. It is a major causative factor for metabolic diseases, including diabetes. Arsenic exposure has been linked to dysfunction in various cell types and tissues, notably affecting pancreatic islet cells. Numerous mechanisms have been identified to be responsible for arsenic exposure under both in vitro and in vivo conditions. These mechanisms contribute to the regulation of processes underlying diabetes etiology, such as glucose-stimulated insulin secretion from pancreatic beta cells. Unlike other toxic elements, arsenic undergoes metabolism by living organisms, including microbes, plants, and animals. Other toxic elements like Lead (Pb) and mercury (Hg) are generally not metabolized in the same way as Arsenic in microbes, plants and animals. In this review, we strive to initiate a dialogue by reviewing known aspects of microbe-arsenic interactions and placing it in the context of the potential for influencing host exposure and health risks. This review provides an up-to-date insight into arsenic metabolism by the human body and its associated microbiota, as well as the deciphered molecular pathways linking the different species of arsenic in the etiology of diabetes. Additionally, the future perspectives of mitigation and detoxification of arsenic in translational medicine and limitations in current scenarios are discussed. The comprehensive review presented here underscores the importance of exploring the complex interplay between arsenic metabolism, host-microbiota interactions, and their implications on glucose homeostasis and metabolic diseases. It emphasizes the need for continued research to develop effective strategies for mitigating arsenic-related health risks and fostering better translational medicine approaches.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Arsenic",
+ "Homeostasis",
+ "Animals",
+ "Glucose",
+ "Diabetes Mellitus",
+ "Microbiota",
+ "Gastrointestinal Microbiome"
+ ]
+ },
+ {
+ "PMID": "39673957",
+ "Title": "Biosensors & bioelectronics",
+ "ArticleTitle": "Highly sensitive and real-time detection of acetone biomarker for diabetes using a ZnO-coated optical fiber sensor.",
+ "Abstract": "This work presents a ZnO-coated no-core optical fiber sensor (OFS) designed for the highly sensitive detection of acetone vapor. Acetone is a key biomarker for diabetes, which is linked to blood glucose levels and can be detected non-invasively through breath analysis. The OFS utilizes a no-core fiber (NCF) as the sensing region, coated with a thin layer of ZnO nanoparticles to enhance evanescent field interaction with the VOCs at the fiber interface. The NCF segment, optimized to 3.4\u00a0cm, maximizes coupling efficiency through multi-mode interference (MMI). The OFS was tested with six different VOCs including acetone, methanol, ethanol, isopropanol, toluene and xylene at concentrations ranging from 1 to 10\u00a0ppm, as they are commonly exhaled VOCs associated with diabetes. The fabricated OFS demonstrated high sensitivity to acetone (0.116\u00a0nm/ppm) and excellent selectivity compared to other VOCs. It exhibited a lower detection limit of 3.26\u00a0ppm, rapid response (26\u00a0s), and recovery times (32\u00a0s) for acetone, with minimal drift (0.2%) over 30 days. Operated at room temperature, this ZnO-coated no-core OFS offers a cost-effective and simple fabrication approach, showing promising potential for non-invasive acetone monitoring in diabetes.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Acetone",
+ "Zinc Oxide",
+ "Biosensing Techniques",
+ "Humans",
+ "Optical Fibers",
+ "Diabetes Mellitus",
+ "Biomarkers",
+ "Limit of Detection",
+ "Breath Tests",
+ "Equipment Design",
+ "Volatile Organic Compounds",
+ "Fiber Optic Technology"
+ ]
+ },
+ {
+ "PMID": "39673919",
+ "Title": "Cancer epidemiology",
+ "ArticleTitle": "Co-occurrence of cancer and diabetes in a high-income country: Age-period-cohort projections 2020-2044.",
+ "Abstract": "Our findings reinforce the fact that diabetes prevention activities are also cancer prevention activities, and must therefore be prioritised and resourced in tandem. The projected volume of diabetes and cancer co-occurrence also has important policy implications in terms of workforce development, as well as service delivery.",
+ "Predictions": [
+ "Diabetes",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neoplasms",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Incidence",
+ "Adult",
+ "Aged",
+ "Diabetes Mellitus",
+ "New Zealand",
+ "Young Adult",
+ "Registries",
+ "Cohort Studies",
+ "Adolescent",
+ "Aged, 80 and over",
+ "Child"
+ ]
+ },
+ {
+ "PMID": "39673498",
+ "Title": "Family practice",
+ "ArticleTitle": "The relationship between self-care preparedness and quality of life in a 3-year-follow-up: a study in primary health care.",
+ "Abstract": "Those patients who managed to increase their SCPI over the study period experienced an improvement in HRQoL.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "Male",
+ "Female",
+ "Self Care",
+ "Primary Health Care",
+ "Middle Aged",
+ "Aged",
+ "Follow-Up Studies",
+ "Longitudinal Studies",
+ "Hypertension",
+ "Coronary Artery Disease",
+ "Diabetes Mellitus",
+ "Adult",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39672014",
+ "Title": "Computers in biology and medicine",
+ "ArticleTitle": "Exploring diabetes through the lens of AI and computer vision: Methods and future prospects.",
+ "Abstract": "Early diagnosis and timely initiation of treatment plans for diabetes are crucial for ensuring individuals' well-being. Emerging technologies like artificial intelligence (AI) and computer vision are highly regarded for their ability to enhance the accessibility of large datasets for dynamic training and deliver efficient real-time intelligent technologies and predictable models. The application of AI and computer vision techniques to enhance the analysis of clinical data is referred to as eHealth solutions that employ advanced approaches to aid medical applications. This study examines several advancements and applications of machine learning, deep learning, and machine vision in global perception, with a focus on sustainability. This article discusses the significance of utilizing artificial intelligence and computer vision to detect diabetes, as it has the potential to significantly mitigate harm to human life. This paper provides several comments addressing challenges and recommendations for the use of this technology in the field of diabetes. This study explores the potential of employing Industry 4.0 technologies, including machine learning, deep learning, and computer vision robotics, as effective tools for effectively dealing with diabetes related aspects.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus",
+ "Artificial Intelligence",
+ "Machine Learning",
+ "Deep Learning",
+ "Telemedicine"
+ ]
+ },
+ {
+ "PMID": "39671511",
+ "Title": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
+ "ArticleTitle": "Associations of nonoccupational sedentary behaviors with cardiometabolic outcomes: coronary artery risk development in young adults (CARDIA).",
+ "Abstract": "When comparing total-SB and the 6 context-specific SBs, TV-SB was most robustly associated with HTN. The findings were less clear for DM. Behavior change strategies that target TV-SB reduction may be effective at reducing HTN risk in middle-aged adults.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sedentary Behavior",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Hypertension",
+ "Middle Aged",
+ "Adult",
+ "Diabetes Mellitus",
+ "Exercise",
+ "Coronary Artery Disease",
+ "Prospective Studies",
+ "Young Adult",
+ "Cardiometabolic Risk Factors",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39671417",
+ "Title": "Puerto Rico health sciences journal",
+ "ArticleTitle": "Are Patients who are Diagnosed with Hypertension or Diabetes more likely to Receive the COVID-19 Booster? Data from PR-CEAL's Community Survey Tool.",
+ "Abstract": "Insights from this study can inform future vaccination campaigns through improved awareness and prevention strategies by targeting vulnerable populations in Puerto Rico.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hypertension",
+ "Female",
+ "Male",
+ "COVID-19",
+ "Adult",
+ "Diabetes Mellitus",
+ "Middle Aged",
+ "Puerto Rico",
+ "COVID-19 Vaccines",
+ "Aged",
+ "Surveys and Questionnaires",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39670874",
+ "Title": "Hepatology communications",
+ "ArticleTitle": "Pain in chronic liver disease compared to other chronic conditions: Results from a contemporary nationally representative cohort study.",
+ "Abstract": "Liver disease independently increases the likelihood of experiencing widespread and debilitating pain. Clinicians should consider liver disease a painful condition, ensuring that they are frequently assessing and appropriately treating pain in all liver disease patients.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Liver Diseases",
+ "Aged",
+ "Analgesics, Opioid",
+ "United States",
+ "Liver Cirrhosis",
+ "Chronic Disease",
+ "Cohort Studies",
+ "Liver Neoplasms",
+ "Diabetes Mellitus",
+ "Logistic Models",
+ "Arthritis",
+ "Health Surveys",
+ "Chronic Pain",
+ "Hepatitis, Viral, Human",
+ "Renal Insufficiency, Chronic",
+ "Severity of Illness Index"
+ ]
+ },
+ {
+ "PMID": "39670442",
+ "Title": "Expert opinion on therapeutic targets",
+ "ArticleTitle": "Lipocalin-2 as a therapeutic target for diabetes neurological complications.",
+ "Abstract": "To fully grasp the impact of LCN2 on neurological health, it is essential to understand its multifaceted role in metabolic regulation. Because effective LCN2-targeting drugs must penetrate the blood - brain barrier, various strategies are being developed to meet this requirement. Such therapeutics could treat various neurological complications, including diabetic encephalopathy, retinopathy, and peripheral neuropathy. While animal models offer insights into pathophysiology and potential treatments, their limitations must be acknowledged. Therefore, future research should bridge the gaps between animal findings, human studies, and clinical applications. Moreover, comprehensive personalized approaches, including LCN2-targeting drugs, lifestyle changes, and regularly monitoring individual patients, may be required to manage diabetic complications.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Animals",
+ "Lipocalin-2",
+ "Diabetic Neuropathies",
+ "Oxidative Stress",
+ "Molecular Targeted Therapy",
+ "Quality of Life",
+ "Cognitive Dysfunction",
+ "Drug Development",
+ "Blood-Brain Barrier",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39670363",
+ "Title": "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing",
+ "ArticleTitle": "LLM-CGM: A Benchmark for Large Language Model-Enabled Querying of Continuous Glucose Monitoring Data for Conversational Diabetes Management.",
+ "Abstract": "Over the past decade, wearable technology has dramatically changed how patients manage chronic diseases. The widespread availability of on-body sensors, such as heart rate monitors and continuous glucose monitoring (CGM) sensors, has allowed patients to have real-time data about their health. Most of these data are readily available on patients' smartphone applications, where patients can view their current and retrospective data. For patients with diabetes, CGM has transformed how their disease is managed. Many sensor devices interface with smartphones to display charts, metrics, and alerts. However, these metrics and plots may be challenging for some patients to interpret. In this work, we explore how large language models (LLMs) can be used to answer questions about CGM data. We produce an open-source benchmark of time-series question-answering tasks for CGM data in diabetes management. We evaluate different LLM frameworks to provide a performance benchmark. Lastly, we highlight the need for more research on how to optimize LLM frameworks to best handle questions about wearable data. Our benchmark is publicly available for future use and development. While this benchmark is specifically designed for diabetes care, our model implementation and several of the statistical tasks can be extended to other wearable device domains.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose Self-Monitoring",
+ "Computational Biology",
+ "Diabetes Mellitus",
+ "Benchmarking",
+ "Blood Glucose",
+ "Wearable Electronic Devices",
+ "Smartphone",
+ "Mobile Applications",
+ "Language",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39667764",
+ "Title": "Zhonghua yi xue za zhi",
+ "ArticleTitle": "[The value of local antibiotics for foot infection in persons with diabetes].",
+ "Abstract": "Diabetes-related foot infections(DFI), including diabetes-related foot osteomyelitis, are generally treated with systemic antibiotics. However, systemic antibiotics are often overused and administered for excessively long periods, making patients more susceptible to multidrug-resistant bacteria. Local antibiotics may be beneficial to DFI patients. This article reviews the advantages and disadvantages, types and clinical evidence of local antibiotics in the treatment of DFI, and points out the research gaps and future research direction in this field. This article aims to provide a reference for clinicians in formulating anti-infectious treatment plans for DFI.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Anti-Bacterial Agents",
+ "Diabetic Foot",
+ "Osteomyelitis",
+ "Diabetes Mellitus",
+ "Anti-Infective Agents, Local"
+ ]
+ },
+ {
+ "PMID": "39666834",
+ "Title": "Annals of the New York Academy of Sciences",
+ "ArticleTitle": "Diabetes and cardiovascular disease in older adults.",
+ "Abstract": "An aging population combined with a rapidly increasing prevalence of diabetes foreshadows a global epidemic of cardiovascular and kidney disease that threatens to halt improvements in life and health-span and will have particularly severe consequences in older adults. The management of diabetes has been transformed with the recent development of newer anti-hyperglycemic agents that have demonstrated superior efficacy. However, the utility of these drugs extends beyond glycemic control to benefits for managing obesity, cardiovascular disease (CVD), chronic kidney disease, and heart failure. Numerous cardiovascular and kidney outcomes trials of these drugs have played an instrumental role in shaping current guidelines for the management of diabetes and CVD. Older adults with diabetes are diverse in terms of their comorbidities, diabetic complications, and cognitive and functional status. Therefore, there is an unmet need for personalized management of diabetes and CVD in this population. In this review, we provide an overview of the epidemiological burden and management of diabetes and CVD in older adults. We then focus on randomized cardiovascular and kidney outcome trials with anti-hyperglycemic agents to propose an evidence-based approach to the management of diabetes in older adults with high risk of cardiovascular and kidney disease.",
+ "Predictions": [
+ "Diabetes",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Aged",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39666732",
+ "Title": "PloS one",
+ "ArticleTitle": "SHINE study: Developing an intervention for safe hospital insulin use for older or frail adults with diabetes undergoing surgical hospital admission: Study protocol.",
+ "Abstract": "This article outlines the methodology for the planned study which will employ a novel methodology to tackle the problem of hospital insulin safety. Its findings will contribute to a better understanding of the multiple interacting components implicated in hospital insulin use (patient, staff, context) and support further work around system-based strategies to enhance insulin safety resilience in hospital.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Insulin",
+ "Aged",
+ "Diabetes Mellitus",
+ "Hospitalization",
+ "Frail Elderly",
+ "Hypoglycemic Agents",
+ "Female",
+ "Male",
+ "Hospitals"
+ ]
+ },
+ {
+ "PMID": "39666445",
+ "Title": "ACS biomaterials science & engineering",
+ "ArticleTitle": "Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration.",
+ "Abstract": "The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede bone regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system in the diabetic microenvironment will result in a high rate of impaired, delayed, or even nonhealing events of bone tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems to treat diabetic bone defects via the combination of microenvironmental regulation and enhanced osteogenic capacity. Following the natural bone healing processes, coupling of angiogenesis and osteogenesis by advanced bioresponsive drug delivery systems has proved to be of significant approach for promoting bone repair in DM. In this Review, we have systematically summarized the mechanisms and therapeutic strategies of DM-induced impaired bone healing, outlined the bioresponsive design for drug delivery systems, and highlighted the vascularization strategies for promoting bone regeneration. Accordingly, we then overview the recent advances in developing bioresponsive drug delivery systems to facilitate diabetic vascularized bone regeneration by remodeling the microenvironment and modulating multiple regenerative cues. Furthermore, we discuss the development of adaptable drug delivery systems with unique features for guiding DM-associated bone regeneration in the future.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Bone Regeneration",
+ "Humans",
+ "Drug Delivery Systems",
+ "Animals",
+ "Diabetes Mellitus",
+ "Neovascularization, Physiologic",
+ "Osteogenesis",
+ "Biocompatible Materials"
+ ]
+ },
+ {
+ "PMID": "39666416",
+ "Title": "Medicina",
+ "ArticleTitle": "[Advances in continuous glucose monitoring: evidence of a new generation technology].",
+ "Abstract": "Continuous glucose monitoring (CGM) provides comprehensive and dynamic information to guide the management of diabetes mellitus (DM). This paper summarizes the evidence and implications of the use of the new CGM system, FreeStyle Libre 2 (FSL2). A global review of the literature on the use of FSL2 in people with DM was performed. All types of studies were included. The evidence is presented qualitatively together with expert clinical opinion. FSL2 is an integrated CGM system with real-time glucose readings (no scanning required) and customizable alarms. In studies of subjects aged 2 years and older with DM1 or DM2, the overall mean absolute relative difference for FSL2 was 8.2%, with a high degree of clinical accuracy. Compared to blood monitoring in DM1, studies show higher time within range, lower time below range and lower time above range at 4, 8 and 12 weeks of FSL2 use. These results were confirmed in observational studies in DM, where the majority of FSL2 users reported greater satisfaction with treatment and a significant improvement in quality of life. In concluded, Including the FSL2 system in the management of people with DM would also reduce the risks associated with DM complications, improving the prognosis of this population and allowing for the appropriate use of healthcare resources.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose Self-Monitoring",
+ "Blood Glucose",
+ "Diabetes Mellitus",
+ "Quality of Life",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39666397",
+ "Title": "Medicina",
+ "ArticleTitle": "Risk factors associated with invasive pulmonary aspergillosis in severe COVID-19 patients: a casecontrol study.",
+ "Abstract": "A history of diabetes, smoking, coronary artery disease, and a Charlson score equal to or greater than 5 may increase the risk of developing CAPA.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Risk Factors",
+ "COVID-19",
+ "Invasive Pulmonary Aspergillosis",
+ "Retrospective Studies",
+ "Case-Control Studies",
+ "Aged",
+ "Severity of Illness Index",
+ "SARS-CoV-2",
+ "Smoking",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39665943",
+ "Title": "Nefrologia",
+ "ArticleTitle": "Study of the association of markers of central and peripheral arterial stiffness with renal function in patients with arterial hypertension, diabetes mellitus and chronic kidney disease.",
+ "Abstract": "Aortic stiffness increases in the presence of vascular risk factors such as hypertension, DM and CKD. This increase is greater when DM and CKD coexist. Increased aortic stiffness is inversely associated with GFR and directly with uALB, and is predictive of decreased GFR and abnormal uALB. The VP",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Vascular Stiffness",
+ "Male",
+ "Renal Insufficiency, Chronic",
+ "Female",
+ "Middle Aged",
+ "Hypertension",
+ "Glomerular Filtration Rate",
+ "Aged",
+ "Biomarkers",
+ "Albuminuria",
+ "Kidney",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39665157",
+ "Title": "Clinical science (London, England : 1979)",
+ "ArticleTitle": "Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients.",
+ "Abstract": "Transglutaminase 2 (TG2) is an enzyme with multiple conformations. In its open conformation, TG2 exhibits transamidase activity linked to fibrosis, arterial remodeling, and endothelial dysfunction, a process enhanced by high glucose in endothelial cells. However, the closed conformation of TG2 contributes to transmembrane signaling and nitric oxide (NO)-dependent vasorelaxation. LDN 27219, a reversible allosteric inhibitor, stabilizes TG2 in its closed conformation. We examined whether pharmacological modulation of TG2 into its closed conformation induces vasorelaxation and enhances endothelium-dependent and independent relaxation in resistance arteries from age-matched diabetic (n = 14) and non-diabetic patients (n = 14) (age 71 (Standard Error of the Mean: \u00b1 2)). Subcutaneous arteries (diameter 133-1013 \u00b5m) were isolated from abdominal fat biopsies. TG2 mRNA expression and transamidase activity were assessed via RT-qPCR and 5-biotin(amido)pentylamine (5-BP) incorporation, while vascular reactivity was measured using wire myography. TG2 mRNA was highly expressed without significant differences between the groups and LDN 27219 induced concentration-dependent vasorelaxation in arteries from both groups. Sex-specific analysis revealed that potentiation of acetylcholine-induced vasorelaxation by LDN 27219 was driven by increased TG2 expression in non-diabetic females, whereas no effect was observed in arteries from non-diabetic males. Among diabetic patients, LDN 27219 increased maximal acetylcholine-induced vasorelaxation in males only. LDN 27219 did not affect endothelium-independent relaxation to sodium nitroprusside in either group. In conclusion, TG2 is expressed in human resistance arteries, and LDN 27219 induced vasorelaxation, selectively enhancing ACh relaxation in non-diabetic females, likely owing to increased TG2 expression. This finding underscores the importance of sex differences in TG2 modulation of vasorelaxation.",
+ "Predictions": [
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Protein Glutamine gamma Glutamyltransferase 2",
+ "Transglutaminases",
+ "Male",
+ "Female",
+ "Aged",
+ "Vasodilation",
+ "Endothelium, Vascular",
+ "GTP-Binding Proteins",
+ "Arteries",
+ "Vascular Resistance",
+ "Sex Factors",
+ "Diabetes Mellitus",
+ "Vasodilator Agents",
+ "Enzyme Inhibitors",
+ "Middle Aged"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/diabetes_type_1.json b/model/dataset/diabetes_type_1.json
new file mode 100644
index 0000000000000000000000000000000000000000..73c9a17abb0959f71b6907b073c7ef21698297e3
--- /dev/null
+++ b/model/dataset/diabetes_type_1.json
@@ -0,0 +1,2391 @@
+[
+ {
+ "PMID": "39737893",
+ "Title": "Nutrition & diabetes",
+ "ArticleTitle": "The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.",
+ "Abstract": "There is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Male",
+ "Female",
+ "Nutrition Surveys",
+ "Middle Aged",
+ "Genome-Wide Association Study",
+ "Arthritis, Rheumatoid",
+ "Adult",
+ "Arthritis",
+ "Prevalence",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Aged",
+ "Genetic Predisposition to Disease",
+ "Logistic Models",
+ "Polymorphism, Single Nucleotide"
+ ]
+ },
+ {
+ "PMID": "39737643",
+ "Title": "Journal of biomedical materials research. Part B, Applied biomaterials",
+ "ArticleTitle": "Beneficial Effects of Tilapia Fish Skin on Excisional Skin Wound Healing in a Type I Diabetic Rat Model.",
+ "Abstract": "IntroductionProlonged hyperglycemia in diabetic patients often impairs wound healing, leading to chronic infections and complications. This study aimed to evaluate the potential of fresh Tilapia fish skin as a treatment to enhance wound healing in diabetic rats. MethodsThirty-nine healthy adult albino rats, weighing between 150 and 200\u2009g, were divided into three groups: non-diabetic rats with untreated wounds [C-], diabetic rats with untreated wounds [C+], and diabetic rats treated with fresh Tilapia skin [TT]. The healing process was monitored through clinical observation, gross examination, and histopathological analysis. ResultsThe results demonstrated that the Tilapia skin treatment accelerated wound healing, as evidenced by complete reepithelialization, full epidermal cell differentiation, an intact dermo-epidermal junction, and a reorganized dermis with fewer blood vessels. ConclusionFresh Tilapia skin proved to be a safe and effective dressing for promoting wound healing and managing infection in diabetic wounds.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Tilapia",
+ "Rats",
+ "Skin",
+ "Wound Healing",
+ "Diabetes Mellitus, Experimental",
+ "Diabetes Mellitus, Type 1",
+ "Male"
+ ]
+ },
+ {
+ "PMID": "39736868",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents.",
+ "Abstract": "www.ClinicalTrials.gov, identifier NCT03103867.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Hypoglycemia",
+ "Child",
+ "Female",
+ "Parents",
+ "Adolescent",
+ "Fear",
+ "Cross-Over Studies",
+ "Adult",
+ "Sleep",
+ "Middle Aged",
+ "Insulin Infusion Systems",
+ "Blood Glucose Self-Monitoring",
+ "Insulin",
+ "Blood Glucose",
+ "Hypoglycemic Agents"
+ ]
+ },
+ {
+ "PMID": "39736865",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus - an exploratory study.",
+ "Abstract": "Both T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Ultrasonography",
+ "Aged",
+ "Middle Aged",
+ "Bone Density",
+ "Diabetes Mellitus, Type 2",
+ "Tibia",
+ "Absorptiometry, Photon",
+ "Case-Control Studies",
+ "Diabetes Mellitus, Type 1",
+ "Cortical Bone",
+ "Elasticity"
+ ]
+ },
+ {
+ "PMID": "39735417",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation.",
+ "Abstract": "Type 1 diabetes (T1D) is an autoimmune chronic disorder that damages beta cells in the pancreatic islets of Langerhans and results in hyperglycemia due to the loss of insulin. Exogenous insulin therapy can save lives but does not stop disease progression. Thus, an effective therapy may require beta cell restoration and suppression of the autoimmune response. However, currently, there are no treatment options available that can reverse T1D. Within the National Clinical Trial (NCT) database, a majority of over 3000 trials to treat T1D are devoted to insulin therapy. This review focuses on noninsulin pharmacological therapies, specifically immunomodulators. Many investigational new drugs fall under this category, such as the recently FDA-approved CD3 monoclonal antibody teplizumab to delay the onset of T1D. In total, we identified 39 different immunomodulatory investigational drugs. FDA-approved teplizumab for Stage 2 T1D is discussed along with other immunomodulators that have been tested in Phase 3 clinical trials or higher, including otelixizumab (another anti-CD3 monoclonal antibody), daclizumab (an anti-CD25 monoclonal antibody), ladarixin (CXCR1/2 inhibitor), and antithymocyte globulin (ATG). Immunomodulators also play roles in islet transplantation and cellular therapies like FDA-approved Lantidra. Several immunomodulators involved in Phase 3 clinical studies of islet transplantation are also discussed, including alemtuzumab, basiliximab, etanercept, and reparixin, some already FDA-approved for other uses. These include alemtuzumab, basiliximab, etanercept, and reparixin, some of which have been FDA-approved for other uses. This review provides background, mechanism of action, results of completed trials, and adverse effects as well as details regarding ongoing clinical trials for each of these immunomodulators. ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Islets of Langerhans Transplantation",
+ "Immunomodulating Agents",
+ "Immunologic Factors",
+ "Animals",
+ "Antibodies, Monoclonal, Humanized"
+ ]
+ },
+ {
+ "PMID": "39733989",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Duration of physical activity required to Ameliorate hyperglycemia without causing hypoglycemia in type 1 diabetes: A T1DEXI adults and pediatric cohort analyses.",
+ "Abstract": "Time-limited activity is an effective means of restoring TIR when hyperglycemia exists in adolescents and adults with T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Hypoglycemia",
+ "Male",
+ "Adult",
+ "Female",
+ "Blood Glucose",
+ "Hyperglycemia",
+ "Exercise",
+ "Child",
+ "Young Adult",
+ "Cohort Studies",
+ "Hypoglycemic Agents",
+ "Middle Aged",
+ "Time Factors",
+ "Insulin",
+ "Blood Glucose Self-Monitoring"
+ ]
+ },
+ {
+ "PMID": "39733115",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Dynamic modeling of the Insulin-Glucose-Glucocorticoid impulsive control system.",
+ "Abstract": "This paper introduces a class of insulin-glucose-glucocorticoid impulsive systems in the treatment of patients with diabetes to consider the effect of glucocorticoids. The existence and uniqueness of the positive periodic solution of the impulsive model at double fixed time is confirmed for type 1 diabetes mellitus (T1DM) using the [Formula: see text] function. Further, the global asymptotic stability of the positive periodic solution is achieved following Floquet multiplier theory and comparison principle. Additionally, the permanence of the system is confirmed in type 2 diabetes mellitus (T2DM) via the comparison theorem. Numerical analysis verifies the results of theoretical calculations and indicates that combining therapeutic strategies under hormonal interactions with the dose of exogenous insulin and glucocorticoid medicines within organisms provides more reasonable clinical strategies.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Insulin",
+ "Glucocorticoids",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Glucose",
+ "Blood Glucose",
+ "Models, Biological"
+ ]
+ },
+ {
+ "PMID": "39732907",
+ "Title": "Scientific reports",
+ "ArticleTitle": "A reinforcement learning approach to effective forecasting of pediatric hypoglycemia in diabetes I patients using an extended de Bruijn graph.",
+ "Abstract": "Pediatric diabetes I is an endemic and an especially difficult disease; indeed, at this point, there does not exist a cure, but only careful management that relies on anticipating hypoglycemia. The changing physiology of children producing unique blood glucose signatures, coupled with inconsistent activities, e.g., playing, eating, napping, makes \"forecasting\" elusive. While work has been done for adult diabetes I, this does not successfully translate for children. In the work presented here, we adopt a reinforcement approach by leveraging the de Bruijn graph that has had success in detecting patterns in sequences of symbols-most notably, genomics and proteomics. We translate a continuous signal of blood glucose levels into an alphabet that then can be used to build a de Bruijn, with some extensions, to determine blood glucose states. The graph allows us to \"tune\" its efficacy by computationally ignoring edges that provide either no information or are not related to entering a hypoglycemic episode. We can then use paths in the graph to anticipate hypoglycemia in advance of about 30 minutes sufficient for a clinical setting and additionally find actionable rules that accurate and effective. All the code developed for this study can be found at: https://github.com/KurbanIntelligenceLab/dBG-Hypoglycemia-Forecast .",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hypoglycemia",
+ "Diabetes Mellitus, Type 1",
+ "Child",
+ "Blood Glucose",
+ "Forecasting",
+ "Algorithms",
+ "Reinforcement, Psychology"
+ ]
+ },
+ {
+ "PMID": "39732545",
+ "Title": "Endocrinologia, diabetes y nutricion",
+ "ArticleTitle": "Nurse-led therapeutic patient education program on glycemic control and emotional wellbeing in adolescents with type 1 diabetes mellitus during hospital transition.",
+ "Abstract": "The structured therapeutic education program for adolescents with T1DM transitioning from pediatric to adult care maintains glycemic control and emotional wellbeing.",
+ "Predictions": [
+ "Mental Health",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Patient Education as Topic",
+ "Glycemic Control",
+ "Transition to Adult Care",
+ "Self Care",
+ "Emotions",
+ "Mental Health",
+ "Feeding and Eating Disorders"
+ ]
+ },
+ {
+ "PMID": "39731141",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Prevalence and associated factors of psychiatric problems in children aged 6-18 years with type-1 diabetes mellitus in Gondar, Ethiopia: a cross-sectional study.",
+ "Abstract": "The prevalence of psychiatric problems in diabetic children was significantly high and children living with single parent, paternal educational status, glycemic control, family history of diabetes, and family size were found to have significant association with the occurrence of psychiatric problems in diabetic children.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Male",
+ "Child",
+ "Female",
+ "Cross-Sectional Studies",
+ "Ethiopia",
+ "Diabetes Mellitus, Type 1",
+ "Prevalence",
+ "Mental Disorders",
+ "Risk Factors",
+ "Follow-Up Studies"
+ ]
+ },
+ {
+ "PMID": "39730838",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches.",
+ "Abstract": "A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a more direct approach and is now increasingly used in clinical and research studies. We investigated the concordance between WGS-based and array-based T1DGRS across genetic ancestries in 149,265 UK Biobank participants using WGS, TOPMed-imputed, and 1000 Genomes-imputed array genotypes. In the overall cohort, WGS-based T1DGRS demonstrated strong correlation with TOPMed-imputed array-based score (r\u2009=\u20090.996, average WGS-based score 0.0028 standard deviations (SD) lower, p\u2009<\u200910",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 1",
+ "Genetic Predisposition to Disease",
+ "Genetic Risk Score",
+ "Genome, Human",
+ "Genome-Wide Association Study",
+ "Genotype",
+ "Polymorphism, Single Nucleotide",
+ "Whole Genome Sequencing",
+ "Racial Groups"
+ ]
+ },
+ {
+ "PMID": "39728423",
+ "Title": "Medical sciences (Basel, Switzerland)",
+ "ArticleTitle": "An Unusual Case of Nephrotic Range Proteinuria in a Short-Standing Type 1 Diabetic Patient with Newly Diagnosed Systemic Lupus Erythematosus: A Case Report and Literature Review.",
+ "Abstract": "Lupus podocytopathy is an infrequent anatomopathological entity, so this case is presented as the first reported in Peru, and a literature review is made.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Adult",
+ "Lupus Erythematosus, Systemic",
+ "Diabetes Mellitus, Type 1",
+ "Proteinuria",
+ "Nephrotic Syndrome",
+ "Podocytes"
+ ]
+ },
+ {
+ "PMID": "39727851",
+ "Title": "Biosensors",
+ "ArticleTitle": "Sensing Biomechanical Alterations in Red Blood Cells of Type 1 Diabetes Patients: Potential Markers for Microvascular Complications.",
+ "Abstract": "In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability, allowing them to undergo considerable deformation when passing through the microcirculation. However, this deformability is compromised in Type 1 diabetes mellitus (T1DM) and related pathological conditions. This study aims to investigate the biomechanical properties of RBCs in T1DM patients, focusing on identifying significant mechanical alterations associated with microvascular complications (MCs). We conducted a case-control study involving 38 T1DM subjects recruited from the Diabetes Care Unit at Fondazione Policlinico Gemelli Hospital, comprising 22 without MCs (control group) and 16 with MCs (pathological group). Atomic Force Microscopy was employed to assess RBC biomechanical properties in a liquid environment. We observed significant RBC stiffening in individuals with MCs, particularly during large indentations that mimic microcirculatory deformations. Univariate analysis unveiled significant differences in RBC stiffness (median difference 0.0006 N/m, ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Erythrocytes",
+ "Male",
+ "Female",
+ "Adult",
+ "Case-Control Studies",
+ "Biomechanical Phenomena",
+ "Biomarkers",
+ "Middle Aged",
+ "Microscopy, Atomic Force"
+ ]
+ },
+ {
+ "PMID": "39727210",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Inflammatory Markers and Measures of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.",
+ "Abstract": "URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02936843, NCT02017171.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Autonomic Nervous System",
+ "Autonomic Nervous System Diseases",
+ "Biomarkers",
+ "Cardiovascular Diseases",
+ "Cardiovascular System",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus, Type 1",
+ "Diabetic Neuropathies",
+ "Heart Rate",
+ "Inflammation",
+ "Inflammation Mediators",
+ "Receptors, Urokinase Plasminogen Activator"
+ ]
+ },
+ {
+ "PMID": "39726058",
+ "Title": "Journal of medical case reports",
+ "ArticleTitle": "Immune checkpoint inhibitor-associated diabetic ketoacidosis and insulin-dependent diabetes: a case report.",
+ "Abstract": "This case report underscores the risk of diabetic ketoacidosis linked to nivolumab, even in patients without predisposing factors, emphasizing the need for increased vigilance among both oncologists and physicians. It highlights the importance of monitoring for new-onset diabetes and diabetic ketoacidosis, whether immunotherapy is active or discontinued, and ensuring comprehensive care including hospitalization, insulin management, and diabetes education if diabetic ketoacidosis is diagnosed.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "Male",
+ "Aged",
+ "Immune Checkpoint Inhibitors",
+ "Nivolumab",
+ "Diabetes Mellitus, Type 1",
+ "Insulin",
+ "Adenocarcinoma",
+ "Hypoglycemic Agents",
+ "Antineoplastic Agents, Immunological"
+ ]
+ },
+ {
+ "PMID": "39725378",
+ "Title": "Experimental parasitology",
+ "ArticleTitle": "Impact of acute schistosomiasis mansoni and concurrent type 1 diabetes on pancreatic architecture in mice.",
+ "Abstract": "It is not well understood how type 1 diabetes (T1D) and concomitant acute schistosomiasis mansoni affect pancreatic architecture. Male Swiss mice were administered streptozotocin (single 100\u00a0mg/kg i.p.) and thirty days later infected with 80 Schistosoma mansoni cercariae. Mice were divided into groups (n\u00a0=\u00a05): A (healthy control), B (infected), C (uninfected diabetic), and D (diabetic\u00a0+\u00a0infected) and euthanized at week 9 post-infection. Blood glucose levels, biometry, stereology, and pancreatic histology were evaluated. Groups C and D showed hyperglycemia (>200\u00a0mg/dL). Group B had a higher (+79%) pancreatic mass than A. The endocrine pancreas showed fewer islets of Langerhans (-62%; -50%) and a smaller islet area (-36%; -30%) in C and D, respectively, compared to A. Group D had a smaller (-37%) islet area than B. The volume density of the islets was reduced (-33%) in group C compared to A. Within the exocrine pancreas, the volume density of the pancreatic parenchyma was reduced in groups B (-29%) and D (-26%), and increased in C (+15%) compared to A. Group D was reduced (-35%) compared to C. Group D showed generalized pancreatitis, including disrupted tissue with multiple nuclei of destroyed acinar cells and lost connective tissue and acinar cells with a paucity of zymogen granules. Pancreatic stellate cells were found around areas of distorted architecture. Paired adult worms were found within the pancreatic vessels. In conclusion, concomitant T1D and schistosomiasis mansoni promote extensive exocrine and endocrine changes in the pancreas, whereas pancreatic involvement begins in acute schistosomiasis.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Mice",
+ "Male",
+ "Schistosomiasis mansoni",
+ "Diabetes Mellitus, Type 1",
+ "Pancreas",
+ "Diabetes Mellitus, Experimental",
+ "Blood Glucose",
+ "Schistosoma mansoni",
+ "Islets of Langerhans",
+ "Acute Disease"
+ ]
+ },
+ {
+ "PMID": "39724143",
+ "Title": "PLoS genetics",
+ "ArticleTitle": "Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.",
+ "Abstract": "Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer (NK) cells and late-stage differentiated T cells. There is accumulating evidence that iKIRs regulate T cell-mediated immunity. Recently, we reported that T cell-mediated control was enhanced by iKIRs in chronic viral infections. We hypothesized that in the context of autoimmunity, where an enhanced T cell response might be considered detrimental, iKIRs would have an opposite effect. We studied Type 1 diabetes (T1D) as a paradigmatic example of autoimmunity. In T1D, variation in the Human Leucocyte Antigen (HLA) genes explains up to 50% of the genetic risk, indicating that T cells have a major role in T1D etiopathogenesis. To investigate if iKIRs affect this T cell response, we asked whether HLA associations were modified by iKIR genes. We conducted an immunogenetic analysis of a case-control T1D dataset (N = 11,961) and found that iKIR genes, in the presence of genes encoding their ligands, have a consistent and significant effect on protective HLA class II genetic associations. Our results were validated in an independent data set. We conclude that iKIRs significantly decrease HLA class II protective associations and suggest that iKIRs regulate CD4+ T cell responses in T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Receptors, KIR",
+ "Genetic Predisposition to Disease",
+ "Histocompatibility Antigens Class II",
+ "Killer Cells, Natural",
+ "Case-Control Studies",
+ "Autoimmunity",
+ "T-Lymphocytes",
+ "Male",
+ "Female"
+ ]
+ },
+ {
+ "PMID": "39720308",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Young-Onset Diabetes in Sri Lanka: Experience From the Developing World.",
+ "Abstract": {
+ "b": "Conclusion:",
+ "i": "p"
+ },
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sri Lanka",
+ "Female",
+ "Male",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2",
+ "Age of Onset",
+ "Retrospective Studies",
+ "Prevalence",
+ "Developing Countries",
+ "Child",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Diabetic Ketoacidosis"
+ ]
+ },
+ {
+ "PMID": "39720253",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Sclerostin as a new target of diabetes-induced osteoporosis.",
+ "Abstract": "Sclerostin, a protein synthesized by bone cells, is a product of the ",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Osteoporosis",
+ "Adaptor Proteins, Signal Transducing",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Animals",
+ "Genetic Markers",
+ "Wnt Signaling Pathway",
+ "Bone Morphogenetic Proteins"
+ ]
+ },
+ {
+ "PMID": "39719890",
+ "Title": "Journal of biomedical materials research. Part A",
+ "ArticleTitle": "Supramolecular Peptide Depots for Glucose-Responsive Glucagon Delivery.",
+ "Abstract": "Precise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes in order to mitigate both acute and chronic complications. This study investigates the development of a supramolecular peptide amphiphile (PA) material functionalized with phenylboronic acid (PBA) for glucose-responsive glucagon delivery. The PA-PBA system self-assembles into nanofibrillar hydrogels in the presence of physiological glucose levels, resulting in stable hydrogels capable of releasing glucagon under hypoglycemic conditions. Glucose responsiveness is driven by reversible binding between PBA and glucose, which modulates the electrostatic interactions necessary for hydrogel formation and dissolution. Through comprehensive in\u00a0vitro characterization, including circular dichroism, zeta potential measurements, and rheological assessments, the PA-PBA system is found to exhibit glucose-dependent assembly, enabling controlled glucagon release that is inversely related to glucose concentration. Glucagon release is accelerated under low glucose conditions, simulating a hypoglycemic state, with a reduced rate seen at higher glucose levels. Evaluation of the platform in\u00a0vivo using a type 1 diabetic mouse model demonstrates the efficacy in protecting against insulin-induced hypoglycemia by restoring blood glucose levels following an insulin overdose. The ability to tailor glucagon release in response to fluctuating glucose concentrations underscores the potential of this platform for improving glycemic control. These findings suggest that glucose-stabilized supramolecular peptide hydrogels hold significant promise for responsive drug delivery applications, offering an approach to manage glucose levels in diabetes and other metabolic disorders.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Glucagon",
+ "Animals",
+ "Glucose",
+ "Peptides",
+ "Hydrogels",
+ "Diabetes Mellitus, Experimental",
+ "Blood Glucose",
+ "Mice",
+ "Boronic Acids",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Drug Delivery Systems"
+ ]
+ },
+ {
+ "PMID": "39718005",
+ "Title": "Endocrinology, diabetes & metabolism",
+ "ArticleTitle": "Predicting Time in Range Without Hypoglycaemia Using a Risk Calculator for Intermittently Scanned CGM in Type 1 Diabetes.",
+ "Abstract": "Clinical and socio-economic factors significantly influence OGC in type 1 diabetes. The application of statistical models offers a reliable means of predicting the likelihood of achieving OGC following isCGM system implementation.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Male",
+ "Retrospective Studies",
+ "Hypoglycemia",
+ "Adult",
+ "Blood Glucose Self-Monitoring",
+ "Blood Glucose",
+ "Middle Aged",
+ "Risk Assessment",
+ "Glycemic Control",
+ "Glycated Hemoglobin",
+ "Adolescent",
+ "Young Adult",
+ "Time Factors"
+ ]
+ },
+ {
+ "PMID": "39716288",
+ "Title": "The international journal of behavioral nutrition and physical activity",
+ "ArticleTitle": "The efficacy of using continuous glucose monitoring as a behaviour change tool in populations with and without diabetes: a systematic review and meta-analysis of randomised controlled trials.",
+ "Abstract": "CRD42024514135.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Randomized Controlled Trials as Topic",
+ "Blood Glucose Self-Monitoring",
+ "Diabetes Mellitus, Type 2",
+ "Blood Glucose",
+ "Exercise",
+ "Health Behavior",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Pregnancy",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39715178",
+ "Title": "The American journal of occupational therapy : official publication of the American Occupational Therapy Association",
+ "ArticleTitle": "Telehealth Occupation-Based Coaching for Rural Parents of Children With Type 1 Diabetes: A Randomized Controlled Trial.",
+ "Abstract": "OBC may be more efficacious in helping families to improve health management routines after a child's diagnosis with T1D than usual endocrinology care alone. Most child health outcomes were in target range at the start of the study; therefore, it was not expected to see significant improvements. Plain-Language Summary: Occupational therapy is an untapped resource in the provision of care for children with Type 1 diabetes (T1D). Occupational therapy practitioners can also provide families with evidence-based support to address the self-management skills of children with this chronic condition. This clinical trial examined the preliminary efficacy of a new 12-wk telehealth occupational therapy intervention for rural families with a child living with T1D to improve caregiver diabetes management skills, family participation, and child health. Families who received occupational therapy services were more likely to improve their family participation in meaningful activities and diabetes self-efficacy; however, there were no differences in the child's health outcomes or the family's quality of life.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Male",
+ "Telemedicine",
+ "Child",
+ "Quality of Life",
+ "Rural Population",
+ "Child, Preschool",
+ "Parents",
+ "Mentoring",
+ "Occupational Therapy",
+ "Double-Blind Method",
+ "Pilot Projects",
+ "Glycated Hemoglobin",
+ "Self Efficacy",
+ "Adult",
+ "Parenting"
+ ]
+ },
+ {
+ "PMID": "39714936",
+ "Title": "NEJM evidence",
+ "ArticleTitle": "Automated Insulin Delivery in Older Adults with Type 1 Diabetes.",
+ "Abstract": "In older adults with type 1 diabetes, automated insulin delivery decreased hypoglycemia compared with sensor-augmented pump delivery. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; ClinicalTrials.gov number: NCT04016662.).",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Aged",
+ "Male",
+ "Insulin Infusion Systems",
+ "Insulin",
+ "Cross-Over Studies",
+ "Aged, 80 and over",
+ "Hypoglycemic Agents",
+ "Blood Glucose",
+ "Hypoglycemia",
+ "Glycated Hemoglobin",
+ "Blood Glucose Self-Monitoring"
+ ]
+ },
+ {
+ "PMID": "39710861",
+ "Title": "Journal of pediatric endocrinology & metabolism : JPEM",
+ "ArticleTitle": "Patterns and determinants of serum amylase, lipase concentrations in Indian adolescents and youth with type 1 diabetes.",
+ "Abstract": "We have characterized amylase and lipase concentrations across puberty; poor glycemic control tended to be associated with lower amylase and higher lipase, though these findings did not reach statistical significance. Amylase and lipase concentrations should be monitored in Indian adolescents with T1D, particularly in those with poor metabolic control, puberty, uncontrolled hypothyroidism, or reduced calcium intake, while further longitudinal and larger studies are needed to generalize these findings.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Female",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Cross-Sectional Studies",
+ "Child",
+ "Lipase",
+ "India",
+ "Amylases",
+ "Biomarkers",
+ "Young Adult",
+ "Follow-Up Studies",
+ "Glycated Hemoglobin",
+ "Prognosis",
+ "Adult",
+ "Exocrine Pancreatic Insufficiency"
+ ]
+ },
+ {
+ "PMID": "39709470",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.",
+ "Abstract": "Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated with widespread vascular disease affecting both the kidney and the heart from an early stage. However, the risk of diabetic nephropathy in people with type 1 diabetes is strongly genetically determined, as documented in familial transmission studies. The search for the underlying genes has been extensive, using specific hypotheses, sibling linkage studies and genome-wide association studies (GWAS). The role of the angiotensinI-converting enzyme/kininase II (ACE) gene and genetic variability in ACE levels as a susceptibility and prognostic factor for diabetic nephropathy has been well documented in people with type 1 diabetes. The ACE gene insertion/deletion polymorphism, which is associated with plasma and tissue ACE levels, has been the most studied genomic variant in diabetic nephropathy. Recently, this polymorphism has also been associated with longevity in people with type 1 diabetes. The ACE I/D polymorphism has also been associated with vascular, extra-renal complications including myocardial infarction and lower-limb amputation in this population. Other genes and loci have been identified in linkage studies and GWAS, such as the COL4A3 gene or a region on chromosome 3q with the adiponectin gene. Replication was not always attempted and was rarely achieved, even for GWAS. Overall, effect sizes remain modest and no major gene has been identified, despite the strength of the genetic effect in transmission studies. We searched bibliographic databases for studies reporting genomic variants associated with diabetic nephropathy and meta-analyses of such studies. We selected important relevant studies for further discussion in this narrative review. This brief review attempts to summarise the current knowledge on the genetics of diabetic nephropathy and associated cardiovascular disease in people with type 1 diabetes, and discusses some conceptual and methodological issues relevant to the interpretation of past studies and the design of future ones.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Genetic Predisposition to Disease",
+ "Diabetic Nephropathies",
+ "Diabetes Mellitus, Type 1",
+ "Peptidyl-Dipeptidase A",
+ "Cardiovascular Diseases",
+ "Phenotype",
+ "Genome-Wide Association Study",
+ "Risk Factors",
+ "Polymorphism, Genetic"
+ ]
+ },
+ {
+ "PMID": "39708266",
+ "Title": "Genes & genomics",
+ "ArticleTitle": "Baihu Jia Renshen Decoction may improve skeletal muscle and adipose tissue functions of type I diabetic rats by affecting pancreatic \u03b2-cell function.",
+ "Abstract": "BJRD may influence pancreatic \u03b2-cell function, thereby enhancing the function of the skeletal muscle and adipose tissues in a T1DM rat model.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Rats",
+ "Muscle, Skeletal",
+ "Drugs, Chinese Herbal",
+ "Insulin-Secreting Cells",
+ "Male",
+ "Adipose Tissue",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Experimental",
+ "Rats, Sprague-Dawley"
+ ]
+ },
+ {
+ "PMID": "39707866",
+ "Title": "Endocrinology, diabetes & metabolism",
+ "ArticleTitle": "Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study.",
+ "Abstract": "This first exploratory study in people with T1D supports the potential utility of MPR as a screening tool for subclinical neurocognitive alterations in this population.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pilot Projects",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Cognitive Dysfunction",
+ "Adult",
+ "Early Diagnosis",
+ "Aged",
+ "Retina",
+ "Visual Field Tests",
+ "Diabetic Retinopathy",
+ "Fixation, Ocular",
+ "Neuropsychological Tests"
+ ]
+ },
+ {
+ "PMID": "39707182",
+ "Title": "Molecular medicine (Cambridge, Mass.)",
+ "ArticleTitle": "Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables.",
+ "Abstract": "These findings underscore significant metabolic disturbances in severe DKA and their associations with critical clinical indicators. Future investigations should explore if metabolic alterations in severe DKA can identify patients at increased risk of complications and/or guide future therapeutic interventions.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "Male",
+ "Female",
+ "Child",
+ "Metabolomics",
+ "Adolescent",
+ "Metabolome",
+ "Case-Control Studies",
+ "Diabetes Mellitus, Type 1",
+ "Biomarkers",
+ "Metabolic Networks and Pathways",
+ "Machine Learning"
+ ]
+ },
+ {
+ "PMID": "39706675",
+ "Title": "BMJ open diabetes research & care",
+ "ArticleTitle": "Retrospective derivation of a causal pathway for diabetic ketoacidosis in adult patients with type 2 diabetes mellitus.",
+ "Abstract": "in Detroit, MI, prior ketosis and private or Medicare health insurance were significantly associated with new or recurrent DKA in T2KPDM. Medication non-adherence had a mediating role.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "Male",
+ "Retrospective Studies",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose",
+ "Hypoglycemic Agents",
+ "Risk Factors",
+ "Assessment of Medication Adherence"
+ ]
+ },
+ {
+ "PMID": "39706641",
+ "Title": "Journal of pharmacological sciences",
+ "ArticleTitle": "Okanin alleviates symptoms of nociceptive-like responses in diabetic peripheral neuropathy in type 1 diabetic Wistar rats by regulating the AGEs/NF-\u03baB/Nrf-2 pathway.",
+ "Abstract": "Elevated reactive species and AGEs contribute to deregulation of transcription factors e.g., NF-\u03baB and Nrf2 in diabetic peripheral neuropathy (DPN). Okanin, a bioactive chalcone, is active against redox imbalance, immune response, and pro-inflammatory events. The current investigation assessed effects of okanin in streptozotocin-induced DPN in rats. Wistar rats were divided into 6 groups (n\u00a0=\u00a06): Control, DPN, Okanin 2.5, Okanin 5, Okanin 10, and Gpn (Gabapentin). After 6 weeks of streptozotocin (55\u00a0mg/kg) injection, okanin (2.5, 5, 10\u00a0mg/kg), and gabapentin (50\u00a0mg/kg), were administered for 4 weeks. The streptozotocin-induced reduction in body weight, and increased feed/water intake, insulin, glucose, and HbA1c levels were mitigated by okanin or gabapentin. In DPN rats, Okanin or gabapentin ameliorated insulin resistance and \u03b2-cell function, inflammatory indices, and oxidative stress in the sciatic nerve of rodents thereby culminating in a decrease in hyperalgesia and allodynia. Okanin and streptozotocin-treated rats had significantly declined levels of AGEs, the receptor for AGEs, and NF-\u03baB, and an upsurge in Nrf2 expression. In streptozotocin-induced DPN model, okanin ameliorates nociceptive-like responses by regulating the AGEs/NF-\u03baB/Nrf2 pathway, suggesting that okanin has therapeutic value against DPN which needs further studies involving human subjects.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Rats, Wistar",
+ "Diabetic Neuropathies",
+ "NF-kappa B",
+ "Male",
+ "Diabetes Mellitus, Experimental",
+ "NF-E2-Related Factor 2",
+ "Diabetes Mellitus, Type 1",
+ "Streptozocin",
+ "Gabapentin",
+ "Glycation End Products, Advanced",
+ "Signal Transduction",
+ "Rats",
+ "Oxidative Stress",
+ "Disease Models, Animal"
+ ]
+ },
+ {
+ "PMID": "39706517",
+ "Title": "Neuroscience",
+ "ArticleTitle": "Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain.",
+ "Abstract": "This study explored surface brain morphometry in type 1 diabetes including focus on painful diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with diabetes (18 without DPN, 19 with painless DPN, 19 with painful DPN) and 20 healthy controls. Cortical thickness, sulcus depth, and gyrification were analysed globally and regionally in each group and in the combined diabetes group. Associations with clinical characteristics and pain were assessed. Globally, cortical thickness was reduced in the combined diabetes group and in painful DPN compared to healthy controls. No differences in sulcus depth and gyrification were found. Several regions, including the middle frontal gyrus showed reduced cortical thickness in the combined diabetes- and painful DPN group. The postcentral gyrus exhibited reduced cortical thickness in painful DPN compared to healthy controls, and reduced sulcus depth compared to painless DPN correlating with higher pain intensity. Cortical thinning manifested across the brain cortex in diabetes, especially for painful DPN. Altered postcentral gyrus morphometry may be associated with neuropathic pain. Assessing cortical morphometry may be critical for comprehending central neuropathy and the manifestation of painful DPN in diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Female",
+ "Magnetic Resonance Imaging",
+ "Adult",
+ "Neuralgia",
+ "Diabetic Neuropathies",
+ "Middle Aged",
+ "Brain",
+ "Cerebral Cortex"
+ ]
+ },
+ {
+ "PMID": "39704278",
+ "Title": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
+ "ArticleTitle": "Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors.",
+ "Abstract": "Numerous studies have reported altered cytokine levels in type 1 diabetes (T1D) patients, yet findings remain inconsistent. In this pilot study, we tested the hypothesis that circulating immune markers exhibit sex-based differences in T1D, both prior to and after disease onset. We analyzed 47-48 cytokine, chemokine, and growth factor levels in two cohorts. To assess post-disease differences, we analyzed serum samples from 25 controls and 25 T1D patients. To examine pre-disease progression, we utilized samples from 21 control children and 16 T1D progressors, collected at age 5\u2009years before disease onset. Across all T1D patients and controls, only macrophage colony-stimulating factor and interleukin (IL)-6 showed significant differences. However, we identified notable alterations when comparing sex-age-matched controls and T1D samples. Female T1D patients exhibited lower levels of inflammatory cytokines (tumor necrosis factor-\u03b1, IL-6, IL-1a), Th2 cytokines (IL-4, IL-13), and chemokines (macrophage inflammatory protein (MIP)-1\u03b1, regulated upon activation, normal T cell expressed and secreted, MIP-3) compared to female controls, differences that were not observed in males. Notably, IL-22 was lower in female T1D patients compared to female controls, whereas it was higher in male T1D patients compared to male controls. Male T1D patients showed elevated levels of growth factors (epidermal growth factor, platelet-derived growth factor-AB/BB) compared to male controls. In T1D progressors, growth-regulated alpha was lower compared to controls in both sexes. Multiple regression analysis further revealed associations between cytokine levels and factors such as age, BMI, and breastfeeding duration. Overall, our findings serve as a proof of concept, highlighting the importance of sex-specific differences in T1D pathogenesis. However, follow-up studies with larger sample sizes are needed to validate and generalize these results.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Cytokines",
+ "Diabetes Mellitus, Type 1",
+ "Child",
+ "Chemokines",
+ "Adolescent",
+ "Sex Factors",
+ "Disease Progression",
+ "Child, Preschool",
+ "Intercellular Signaling Peptides and Proteins",
+ "Pilot Projects",
+ "Biomarkers",
+ "Sex Characteristics",
+ "Case-Control Studies"
+ ]
+ },
+ {
+ "PMID": "39704171",
+ "Title": "JCI insight",
+ "ArticleTitle": "The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes.",
+ "Abstract": "Deficits in IL-2 signaling can precipitate autoimmunity by altering the function and survival of FoxP3+ regulatory T cells (Tregs) while high concentrations of IL-2 fuel inflammatory responses. Recently, we showed that the non-beta IL-2 SYNTHORIN molecule SAR444336 (SAR'336) can bypass the induction of autoimmune and inflammatory responses by increasing its reliance on IL-2 receptor \u03b1 chain subunit (CD25) to provide a bona fide IL-2 signal selectively to Tregs, making it an attractive approach for the control of autoimmunity. In this report, we further demonstrate that SAR'336 can support non-beta IL-2 signaling in murine Tregs and limit NK and CD8+ T cells' proliferation and function. Using a murine model of spontaneous type 1 diabetes, we showed that the administration of SAR'336 slows the development of disease in mice by decreasing the degree of insulitis through the expansion of antigen-specific Tregs over Th1 cells in pancreatic islets. Specifically, SAR'336 promoted the differentiation of IL-33-responsive (ST2+), IL-10-producing GATA3+ Tregs over other Treg subsets in the pancreas, demonstrating the ability of this molecule to further orchestrate Treg adaptation. These results offer insight into the capacity of SAR'336 to generate highly specialized, tissue-localized Tregs that promote restoration of homeostasis during ongoing autoimmune disease.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "T-Lymphocytes, Regulatory",
+ "Diabetes Mellitus, Type 1",
+ "Mice",
+ "Interleukin-2",
+ "Disease Models, Animal",
+ "Interleukin-2 Receptor alpha Subunit",
+ "Interleukin-1 Receptor-Like 1 Protein",
+ "Interleukin-33",
+ "Mice, Inbred NOD",
+ "Female",
+ "Signal Transduction",
+ "CD8-Positive T-Lymphocytes",
+ "Islets of Langerhans",
+ "Th1 Cells",
+ "Interleukin-10",
+ "Autoimmunity",
+ "Recombinant Proteins"
+ ]
+ },
+ {
+ "PMID": "39704022",
+ "Title": "Annals of medicine",
+ "ArticleTitle": "Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints.",
+ "Abstract": "Insulin dependency arises from autoimmunity that targets the \u03b2 cells of the pancreas, resulting in Type 1 diabetes (T1D). Despite the fact that T1D patients require insulin for survival, insulin does not provide a cure for this disease or prevent its complications. Despite extensive genetic, molecular, and cellular research on T1D over the years, the translation of this understanding into effective clinical therapies continues to pose a significant obstacle. It is therefore difficult to develop effective clinical treatment strategies without a thorough understanding of disease pathophysiology. Pancreatic tissue bioengineering models of human T1D offer a valuable approach to examining and controlling islet function while tackling various facets of the condition. And in recent years, due to advances in high-throughput omics analysis, the genotypic and molecular profiles of T1D have become finer tuned. The present article will examine recent progress in these areas, along with their utilization and constraints in the realm of T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Bioengineering",
+ "Animals",
+ "Genomics",
+ "Insulin-Secreting Cells",
+ "Proteomics",
+ "Insulin",
+ "Islets of Langerhans"
+ ]
+ },
+ {
+ "PMID": "39703896",
+ "Title": "Journal of nutritional science",
+ "ArticleTitle": "The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.",
+ "Abstract": "Polymorphisms in the vitamin D receptor (VDR) gene (BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236)) and low vitamin D concentrations have previously been associated with type 1 diabetes (T1D). Vitamin D is thought to mediate the switch from a pro-inflammatory Th1 response to an anti-inflammatory Th2 response which is protective against the development of T1D. These associations are inconsistent across studies and population groups. These associations have not been investigated in the South African black population. Thus, this observational, case-control study aims to address this knowledge gap. South African black participants with T1D (cases; n = 182) and healthy controls (n = 151) were genotyped for the four VDR polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Vitamin D levels were measured using high performance liquid chromatography (HPLC). Vitamin D levels were not significantly different between cases and controls (62.8 \u00b1 20.7 vs. 59.5 \u00b1 17.0 nmol/l, respectively; P = 0.122). Higher vitamin D levels were associated with the TaqI TT (P = 0.045) and FokI TT/TC (P = 0.014) genotypes in multivariate analyses. Furthermore, the TaqI TT genotype was associated with T1D status in multivariate analysis (P = 0.040). The FokI CC genotype increases the transcription of ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Receptors, Calcitriol",
+ "South Africa",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Female",
+ "Black People",
+ "Adult",
+ "Case-Control Studies",
+ "Vitamin D",
+ "Genotype",
+ "Young Adult",
+ "Polymorphism, Restriction Fragment Length",
+ "Polymorphism, Single Nucleotide",
+ "Genetic Predisposition to Disease",
+ "Middle Aged",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39703609",
+ "Title": "The Yale journal of biology and medicine",
+ "ArticleTitle": "Pathological Sequelae of SARS-CoV-2: A Review for Clinicians.",
+ "Abstract": "The Coronavirus Disease 2019 (COVID-19) pandemic, driven by the novel coronavirus and its variants, has caused over 518 million infections and 6.25 million deaths globally, leading to a significant health crisis. Beyond its primary respiratory impact, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been implicated in various extra-pulmonary complications. Research studies reveal that the virus affects multiple organs, including the kidneys, liver, pancreas, and central nervous system (CNS), largely due to the widespread expression of Angiotensin Converting Enzyme-2 (ACE-2) receptors. Clinical evidence shows that the virus can induce diabetes by disrupting pancreatic and liver functions as well as cause acute kidney injury. Additionally, neurological complications, including cognitive impairments and neuroinflammation, have been observed in a significant number of COVID-19 patients. This review discusses the mechanisms linking SARS-CoV-2 to acute kidney injury, Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM), emphasizing its effects on pancreatic beta cells, insulin resistance, and the regulation of gluconeogenesis. We also explore how SARS-CoV-2 induces neurological complications, detailing the intricate pathways of neuro-invasion and the potential to trigger conditions such as Alzheimer's disease (AD). By elucidating the metabolic and neurological manifestations of COVID-19 and the underlying pathogenic mechanisms, this review underscores the imperative for continued research and the development of effective therapeutic interventions to mitigate the long-term and short-term impacts of SARS-CoV-2 infection.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "SARS-CoV-2",
+ "Acute Kidney Injury",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39702941",
+ "Title": "Clinical and translational medicine",
+ "ArticleTitle": "LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.",
+ "Abstract": "LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induced immuno-resistant phenotype to pro-inflammatory macrophages. Mature dendritic cells acquire a tolerogenic phenotype via LRH-1/NR5A2-stimulated mitochondria turnover. LRH-1/NR5A2 agonistic activation expands a CD4",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 1",
+ "Dendritic Cells",
+ "Humans",
+ "Macrophages",
+ "Immune Tolerance",
+ "Receptors, Cytoplasmic and Nuclear",
+ "Mitochondria",
+ "Male",
+ "Female",
+ "Phenotype"
+ ]
+ },
+ {
+ "PMID": "39701114",
+ "Title": "The lancet. Diabetes & endocrinology",
+ "ArticleTitle": "Hybrid closed-loop insulin therapy and risk of severe hypoglycaemia and diabetic ketoacidosis in young people (aged 2-20 years) with type 1 diabetes: a population-based study.",
+ "Abstract": "German Center for Diabetes Research, German Diabetes Society, and Robert Koch Institute.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Diabetic Ketoacidosis",
+ "Adolescent",
+ "Female",
+ "Male",
+ "Child",
+ "Hypoglycemia",
+ "Young Adult",
+ "Insulin",
+ "Hypoglycemic Agents",
+ "Insulin Infusion Systems",
+ "Child, Preschool",
+ "Blood Glucose",
+ "Prospective Studies",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39699995",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Limitations in Achieving Glycemic Targets From CGM Data and Persistence of Severe Hypoglycemia in Adults With Type 1 Diabetes Regardless of Insulin Delivery Method.",
+ "Abstract": "Despite use of diabetes technologies, many individuals are unable to achieve glycemic targets and experience severe hypoglycemia, highlighting the need for novel treatments.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Hypoglycemia",
+ "Adult",
+ "Female",
+ "Male",
+ "Insulin",
+ "Middle Aged",
+ "Blood Glucose",
+ "Blood Glucose Self-Monitoring",
+ "Insulin Infusion Systems",
+ "Hypoglycemic Agents",
+ "Retrospective Studies",
+ "Glycemic Control"
+ ]
+ },
+ {
+ "PMID": "39697323",
+ "Title": "Frontiers in immunology",
+ "ArticleTitle": "A novel microRNA promotes coxsackievirus B4 infection of pancreatic \u03b2 cells.",
+ "Abstract": "The epidemiological association of coxsackievirus B infection with type 1 diabetes suggests that therapeutic strategies that reduce viral load could delay or prevent disease onset. Moreover, recent studies suggest that treatment with antiviral agents against coxsackievirus B may help preserve insulin levels in type 1 diabetic patients. In the current study, we performed small RNA-sequencing to show that infection of immortalized trophoblast cells with coxsackievirus caused differential regulation of several miRNAs. One of these, hsa-miR-AMC1, was similarly upregulated in human pancreatic \u03b2 cells infected with coxsackievirus B4. Moreover, treatment of \u03b2 cells with non-cytotoxic concentrations of an antagomir that targets hsa-miR-AMC1 led to decreased CVB4 infection, suggesting a positive feedback loop wherein this microRNA further promotes viral infection. Interestingly, some predicted target genes of hsa-miR-AMC1 are shared with hsa-miR-184, a microRNA that is known to suppress genes that regulate insulin production in pancreatic \u03b2 cells. Consistently, treatment of coxsackievirus B4-infected \u03b2 cells with the hsa-miR-AMC1 antagomir was associated with a trend toward increased insulin production. Taken together, our findings implicate novel hsa-miR-AMC1 as a potential early biomarker of coxsackievirus B4-induced type 1 diabetes and suggest that inhibiting hsa-miR-AMC1 may provide therapeutic benefit to type 1 diabetes patients. Our findings also support the use of trophoblast cells as a model for identifying microRNAs that might be useful diagnostic markers or therapeutic targets for coxsackievirus B-induced type 1 diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "MicroRNAs",
+ "Insulin-Secreting Cells",
+ "Enterovirus B, Human",
+ "Coxsackievirus Infections",
+ "Diabetes Mellitus, Type 1",
+ "Cell Line",
+ "Insulin",
+ "Trophoblasts"
+ ]
+ },
+ {
+ "PMID": "39696373",
+ "Title": "BMC medical informatics and decision making",
+ "ArticleTitle": "A prior-knowledge-guided dynamic attention mechanism to predict nocturnal hypoglycemic events in type 1 diabetes.",
+ "Abstract": "Nocturnal hypoglycemia is a critical problem faced by diabetic patients. Failure to intervene in time can be dangerous for patients. The existing early warning methods struggle to extract crucial information comprehensively from complex multi-source heterogeneous data. In this paper, a deep learning framework with an innovative dynamic attention mechanism is proposed to predict nocturnal hypoglycemic events for type 1 diabetes patients. Features related to nocturnal hypoglycemia are extracted from multi-scale and multi-dimensional data, which enables comprehensive information extraction from diverse sources. Then, we propose a prior-knowledge-guided attention mechanism to enhance the network's learning capability and interpretability. The method was evaluated on a public available clinical dataset, which successfully warned 94.91% of nocturnal hypoglycemic events with an F1-score of 96.35%. By integrating our proposed framework into the nocturnal hypoglycemia early warning model, issues related to feature redundancy and incompleteness were mitigated. Comparative analysis demonstrates that our method outperforms existing approaches, offering superior accuracy and practicality in real-world scenarios.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Hypoglycemia",
+ "Deep Learning"
+ ]
+ },
+ {
+ "PMID": "39696094",
+ "Title": "BMC pediatrics",
+ "ArticleTitle": "Sirolimus alleviated intractable diarrhea of IPEX syndrome: a case report and literature review.",
+ "Abstract": "We reviewed the literature on the use of sirolimus for the treatment of IPEX syndrome over the past two decades.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Sirolimus",
+ "Genetic Diseases, X-Linked",
+ "Diarrhea",
+ "Immunosuppressive Agents",
+ "Forkhead Transcription Factors",
+ "Immune System Diseases",
+ "Infant",
+ "Mutation",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39692076",
+ "Title": "Muscle & nerve",
+ "ArticleTitle": "Validation of the Histamine- and Heat-Induced Axon-Reflex Flare Response in a Nonselected Population of People With Type 1 Diabetes.",
+ "Abstract": "The histamine-induced ARF response is a valid marker for small fiber neuropathy even in nonselected populations with diabetes with good agreement with established markers and can thus be used for evaluation of C-fiber function. The lack of correlation with the heat-induced ARF may be due to insufficient heating.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Histamine",
+ "Female",
+ "Adult",
+ "Hot Temperature",
+ "Middle Aged",
+ "Diabetic Neuropathies",
+ "Axons",
+ "Neural Conduction",
+ "Reflex",
+ "Sural Nerve",
+ "Young Adult",
+ "ROC Curve",
+ "Neurologic Examination"
+ ]
+ },
+ {
+ "PMID": "39691822",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Characteristics of Children, Youth, and Young Adults With Diabetes: A Cross-Sectional Study in New Zealand Aotearoa.",
+ "Abstract": {
+ "b": "Conclusions",
+ "i": "p"
+ },
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "New Zealand",
+ "Cross-Sectional Studies",
+ "Adolescent",
+ "Child",
+ "Diabetes Mellitus, Type 1",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2",
+ "Hypoglycemic Agents",
+ "Prevalence",
+ "Child, Preschool",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Primary Health Care"
+ ]
+ },
+ {
+ "PMID": "39689816",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Men with type 1 diabetes had a more than 7-fold odds of elevated depressive symptoms compared to men without diabetes.",
+ "Abstract": "Our results demonstrate that there is an urgent need to screen adults with T1D for depressive symptoms as part of routine medical care and to test interventions to minimize their impact on physical health outcomes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Middle Aged",
+ "Depression",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Prevalence",
+ "Sex Factors",
+ "Surveys and Questionnaires",
+ "Self-Management"
+ ]
+ },
+ {
+ "PMID": "39689633",
+ "Title": "Patient education and counseling",
+ "ArticleTitle": "Understanding the parental journey: Exploring experiences, needs, and perceptions during hospitalization for children newly diagnosed with type 1 diabetes.",
+ "Abstract": "The study sheds light on families' challenges during initial hospital-based diabetes education, offering insights for healthcare professionals to tailor support strategies and improve diabetes management.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Male",
+ "Parents",
+ "Qualitative Research",
+ "Child",
+ "Adolescent",
+ "Child, Preschool",
+ "Interviews as Topic",
+ "Infant",
+ "Hospitalization",
+ "Adult",
+ "Self Care",
+ "Self-Management",
+ "Perception",
+ "Social Support"
+ ]
+ },
+ {
+ "PMID": "39688288",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Project ECHO Diabetes Trial Improves Outcomes for Medically Underserved People.",
+ "Abstract": "The ECHO model demonstrates promise for reducing health disparities in diabetes and contributes to our understanding of program benefits beyond the provider level.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Middle Aged",
+ "Male",
+ "Adult",
+ "Diabetes Mellitus, Type 2",
+ "Glycated Hemoglobin",
+ "Diabetes Mellitus, Type 1",
+ "Medically Underserved Area",
+ "California",
+ "Florida"
+ ]
+ },
+ {
+ "PMID": "39686350",
+ "Title": "Sensors (Basel, Switzerland)",
+ "ArticleTitle": "Performance of a Non-Invasive System for Monitoring Blood Glucose Levels Based on Near-Infrared Spectroscopy Technology (",
+ "Abstract": [
+ "Overall, 105 subjects (mean age 53.8 \u00b1 13.8 years, 50.5% female) participated, resulting in 1914 paired glucose measurements between 49 and 331 mg/dL. Total mean absolute relative difference (MARD) was 20.3%, MARD for values >100 mg/dL was 18.3%, and mean absolute deviation (MAD) for values <100 mg/dL was 24.9%. A total of 97.3% of measurements fell within A+B Parkes zones, and 58.8%, 76.9%, and 88.1% within +-20%, +-30%, or +-40% error, respectively. On completion, 62 participants (59%) fulfilled the one-week prospective sub-study. In this subgroup, the total MARD was reduced between day 1 and day 8 from 22.8 to 18.3% (",
+ {
+ "i": "Glucube"
+ }
+ ],
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose Self-Monitoring",
+ "Female",
+ "Spectroscopy, Near-Infrared",
+ "Blood Glucose",
+ "Male",
+ "Middle Aged",
+ "Prospective Studies",
+ "Diabetes Mellitus, Type 2",
+ "Adult",
+ "Aged",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39686207",
+ "Title": "Sensors (Basel, Switzerland)",
+ "ArticleTitle": "Hybrid CNN-GRU Model for Real-Time Blood Glucose Forecasting: Enhancing IoT-Based Diabetes Management with AI.",
+ "Abstract": "For people with diabetes, controlling blood glucose level (BGL) is a significant issue since the disease affects how the body metabolizes food, which makes careful insulin regulation necessary. Patients have to manually check their blood sugar levels, which can be laborious and inaccurate. Many variables affect BGL changes, making accurate prediction challenging. To anticipate BGL many steps ahead, we propose a novel hybrid deep learning model framework based on Gated Recurrent Units (GRUs) and Convolutional Neural Networks (CNNs), which can be integrated into the Internet of Things (IoT)-enabled diabetes management systems, improving prediction accuracy and timeliness by allowing real-time data processing on edge devices. While the GRU layer records temporal relationships and sequence information, the CNN layer analyzes the incoming data to extract significant features. Using a publicly accessible type 1 diabetes dataset, the hybrid model's performance is compared to that of the standalone Long Short-Term Memory (LSTM), CNN, and GRU models. The findings show that the hybrid CNN-GRU model performs better than the single models, indicating its potential to significantly improve real-time BGL forecasting in IoT-based diabetes management systems.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Neural Networks, Computer",
+ "Blood Glucose",
+ "Internet of Things",
+ "Deep Learning",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose Self-Monitoring",
+ "Forecasting"
+ ]
+ },
+ {
+ "PMID": "39683492",
+ "Title": "Nutrients",
+ "ArticleTitle": "Metabolic and Hormonal Responses to Isomaltulose Ingestion Before or During Sustained Submaximal Exercise in Adults with Type 1 Diabetes Using Automated Insulin Delivery Systems.",
+ "Abstract": "The consumption of smaller servings of isomaltulose during, rather than as a single isocaloric serving before, submaximal sustained exercise provided (i) a better glycemic protective effect, (ii) a lesser push on pancreatic and gut-mediated glucoregulatory hormones, and (iii) a lower reliance on whole-body carbohydrate oxidation. Such information serves to remind us of the potential importance of nutrition for modulating the metabolic fate of an acute bout of exercise and may help inform best practice guidelines for exercise management in the T1D-sphere.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Isomaltose",
+ "Female",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Middle Aged",
+ "Cross-Over Studies",
+ "Adult",
+ "Exercise",
+ "Insulin",
+ "Blood Glucose",
+ "Insulin Infusion Systems",
+ "Glucagon",
+ "Glucagon-Like Peptide 1"
+ ]
+ },
+ {
+ "PMID": "39683465",
+ "Title": "Nutrients",
+ "ArticleTitle": "Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management.",
+ "Abstract": "Latent autoimmune diabetes of adults (LADA) is the most prevalent form of autoimmune diabetes (AI-D) in adulthood; however, its accurate diagnosis and optimal treatment remain challenging. Vitamin D deficiency (VDD) is commonly observed in LADA patients, while increased vitamin D exposure through supplementation and dietary intake is associated with a reduced incidence of LADA. Although limited, case reports, case-control studies, and randomized clinical trials have examined the effects of vitamin D supplementation-alone or combined with dipeptidyl peptidase-4 inhibitors (DPP4-is)-on glucose regulation, residual \u03b2-cell function, and glutamic acid decarboxylase antibody (GADA65) levels. Findings, while preliminary, indicate that vitamin D supplementation may enhance glycemic control, preserve \u03b2-cell function, and reduce autoimmune activity. Given its accessibility, affordability, and relative safety, vitamin D supplementation presents an attractive adjunct treatment option for LADA patients. This narrative review discusses current evidence on the potential therapeutic benefits of vitamin D supplementation in patients with AI-D, including LADA, who are also vitamin D deficient. Beginning with an exploration of the epidemiological patterns, clinical presentation, and diagnostic framework essential for understanding and identifying LADA, this review then examines the proposed mechanisms through which vitamin D may influence autoimmune modulation of pancreatic \u03b2-cells, integrating recent data pertinent to LADA pathology. By distilling and consolidating existing research, we aim to provide a platform for advancing targeted investigations within this distinct patient population.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Female",
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Dietary Supplements",
+ "Dipeptidyl-Peptidase IV Inhibitors",
+ "Insulin-Secreting Cells",
+ "Latent Autoimmune Diabetes in Adults",
+ "Vitamin D",
+ "Vitamin D Deficiency"
+ ]
+ },
+ {
+ "PMID": "39682744",
+ "Title": "Cells",
+ "ArticleTitle": "Beta-Cell-Derived Extracellular Vesicles: Mediators of Intercellular Communication in the Islet Microenvironment in Type 1 Diabetes.",
+ "Abstract": "Type 1 diabetes (T1D) is a chronic autoimmune disorder characterised by an autoimmune response specifically mounted against the insulin-producing beta cells. Within the islet, high cellular connectivity and extensive vascularisation facilitate intra-islet communication and direct crosstalk with the surrounding tissues and the immune system. During the development of T1D, cytokines and extracellular vesicles released by beta cells can contribute to the recruitment of immune cells, further amplifying autoimmunity and aggravating beta cell damage and dysfunction. In this review, we will evaluate the role of beta-cell-derived extracellular vesicles as mediators of the autoimmune response and discuss their potential for early diagnosis and new therapeutic strategies in T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 1",
+ "Extracellular Vesicles",
+ "Humans",
+ "Insulin-Secreting Cells",
+ "Cell Communication",
+ "Animals",
+ "Islets of Langerhans",
+ "Cellular Microenvironment"
+ ]
+ },
+ {
+ "PMID": "39682729",
+ "Title": "Cells",
+ "ArticleTitle": "Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa.",
+ "Abstract": "Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs-PTPN22, PTPN2, PTPN6, PTPN11, PTP\u03c3, DUSP2, DUSP6 and PTPRK-at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Intestinal Mucosa",
+ "Inflammatory Bowel Diseases",
+ "Celiac Disease",
+ "Protein Tyrosine Phosphatases",
+ "Animals",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39682726",
+ "Title": "Cells",
+ "ArticleTitle": "Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.",
+ "Abstract": "Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer's disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissociated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain potential biological insights into the relevance of HSV-1-induced inflammation in AD and T1D. We observed that differentially expressed genes (DEGs) in HSV-1-infected sc-islets were enriched for genes associated with several autoimmune diseases, most significantly, T1D, but also rheumatoid arthritis, psoriasis, Crohn's disease, and multiple sclerosis, whereas DEGs in HSV-1-infected dcOrgs were exclusively enriched for genes associated with AD. The ACV treatment of sc-islets was not as effective in rescuing transcript perturbations of autoimmune disease-associated genes. Finally, we identified gene ontology categories that were enriched for DEGs that were in common across, or unique to, viral treatment of dcOrgs and sc-islets, such as categories involved in the transferase complex, mitochondrial, and autophagy function. In addition, we compared transcriptomic signatures from HSV-1-infected sc-islets with sc-islets that were infected with the coxsackie B virus (CVB) that had been associated with T1D pathogenesis. Collectively, this study provides tissue-specific insights into the molecular effects of inflammation in AD and T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Organoids",
+ "Alzheimer Disease",
+ "Herpesvirus 1, Human",
+ "Brain",
+ "Herpes Simplex",
+ "Islets of Langerhans",
+ "Autoimmune Diseases",
+ "Stem Cells",
+ "Transcriptome",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39680874",
+ "Title": "JMIR research protocols",
+ "ArticleTitle": "Examining Share plus-A Continuous Glucose Monitoring Plus Data-Sharing Intervention in Older Adults and Their Care Partners: Protocol for a Randomized Control Study.",
+ "Abstract": "DERR1-10.2196/60004.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose Self-Monitoring",
+ "Aged",
+ "Diabetes Mellitus, Type 1",
+ "Caregivers",
+ "Male",
+ "Pilot Projects",
+ "Female",
+ "Feasibility Studies",
+ "Quality of Life",
+ "Middle Aged",
+ "Self-Management",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39680256",
+ "Title": "Current diabetes reports",
+ "ArticleTitle": "Parental Psychosocial Variables and Glycemic Control in T1D Pediatric Age: A Systematic Review.",
+ "Abstract": "Type 1 Diabetes (T1D) in young children can be very complex to manage for their parents since they are the main individuals responsible for T1D tasks. Also, parental psychological adjustment impacts children's glycemic outcomes. This systematic review was performed following the PRISMA guidelines. The search process was conducted in four databases from 2019 to 2024. From a total of 215 studies, 5 were included. We identified five studies that found direct associations between parental psychosocial variables and children's glycemic outcomes. These findings suggest a unidirectional perspective, evidencing the need to examine the longitudinal interplay between these variables. In sum, promoting parental psychological interventions may be fundamental for enhancing children's glycemic outcomes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glycemic Control",
+ "Child",
+ "Diabetes Mellitus, Type 1",
+ "Parents",
+ "Child, Preschool",
+ "Hypoglycemia",
+ "Stress, Psychological",
+ "Infant",
+ "Blood Glucose",
+ "Parent-Child Relations",
+ "Fear"
+ ]
+ },
+ {
+ "PMID": "39679900",
+ "Title": "Endocrinology, diabetes & metabolism",
+ "ArticleTitle": "Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes.",
+ "Abstract": "This study highlights the importance of metabolic health represented by insulin resistance in the development of diabetic complications and cardiovascular events in T1D beyond their weight status.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Female",
+ "Adult",
+ "Obesity",
+ "Diabetes Complications",
+ "Insulin Resistance",
+ "Young Adult",
+ "Cardiovascular Diseases",
+ "Obesity, Metabolically Benign",
+ "Body Mass Index",
+ "Follow-Up Studies",
+ "Adolescent",
+ "Diabetic Neuropathies"
+ ]
+ },
+ {
+ "PMID": "39678192",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Serum exocrine pancreas enzymes are biomarkers of immunotherapy response in new-onset type 1 diabetes.",
+ "Abstract": "Our findings provide preliminary evidence that the exocrine pancreatic enzymes lipase and trypsin may be useful biomarkers of response to immunotherapy in type 1 diabetes. Further studies with larger numbers of participants are warranted.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Biomarkers",
+ "Female",
+ "Lipase",
+ "Adult",
+ "Amylases",
+ "Immunotherapy",
+ "Trypsin",
+ "Young Adult",
+ "Pancreas, Exocrine",
+ "Adolescent",
+ "Granulocyte Colony-Stimulating Factor",
+ "Treatment Outcome",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39676645",
+ "Title": "Cardiology in the young",
+ "ArticleTitle": "Influence of pre-existing maternal diabetes mellitus on fetal myocardial performance index and systolic-to-diastolic duration ratio: a prospective cohort study.",
+ "Abstract": "Pre-existing maternal diabetes mellitus had significant influence on fetal left ventricle myocardial performance index, but no effect on systolic-to-diastolic duration ratio. Systolic-to-diastolic duration ratio was not useful in predicting adverse perinatal outcomes.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Pregnancy",
+ "Prospective Studies",
+ "Adult",
+ "Systole",
+ "Diastole",
+ "Ultrasonography, Prenatal",
+ "Fetal Heart",
+ "Diabetes Mellitus, Type 1",
+ "Echocardiography, Doppler",
+ "Young Adult",
+ "Ventricular Function, Left",
+ "Myocardial Contraction",
+ "Pregnancy in Diabetics",
+ "Stroke Volume",
+ "Diabetes Mellitus, Type 2",
+ "Heart Ventricles"
+ ]
+ },
+ {
+ "PMID": "39676515",
+ "Title": "Current diabetes reviews",
+ "ArticleTitle": "The Teachers' Knowledge of Type 1 Diabetes in Schools: An Interventional Study.",
+ "Abstract": "Our study showed a lack of information about type 1 diabetes among teachers. We also proved the effectiveness of targeted education in correcting misconceptions and encouraging awareness of type 1 diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Health Knowledge, Attitudes, Practice",
+ "Female",
+ "Male",
+ "School Teachers",
+ "Morocco",
+ "Adult",
+ "Surveys and Questionnaires",
+ "Child",
+ "Schools",
+ "Health Education",
+ "School Health Services"
+ ]
+ },
+ {
+ "PMID": "39675543",
+ "Title": "Chemico-biological interactions",
+ "ArticleTitle": "Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice.",
+ "Abstract": "The relationship between arsenic exposure and the development of diabetes mellitus has garnered significant interest in recent years. However, current experimental studies have not definitively established the role of arsenic in the onset of diabetes mellitus. To investigate this relationship specifically concerning type 1 diabetes mellitus, Streptozocin (STZ) was utilized as an inducer to initiate the fundamental pathological changes associated with the disease. A high dose of STZ (50\u00a0mg/kg) served as the positive control, while a low dose of STZ (20\u00a0mg/kg) was administered in combination with arsenic at varying doses. The objective was to determine whether arsenic enhances the effects of STZ, thereby leading to an expedited onset and progression of type 1 diabetes mellitus. The preliminary investigation into the impact of arsenic exposure on experimental type 1 diabetic mice focused on the NLRP3/Caspase-1/GSDMD mediated pyroptosis pathway. The results showed that fasting blood glucose (FBG) was increased, glucose tolerance was impaired, insulin sensitivity was decreased, fasting serum insulin and the homeostatic model assessment-\u03b2 (HOMA-\u03b2) were significantly reduced, hair arsenic content was increased, reactive oxygen species(ROS), interleukin (IL)-1\u03b2 and IL-18 contents were increased, and the pathological morphology of pancreas was more serious in the combined group. Moreover, the expression levels of proteins associated with the NLRP3/Caspase-1/GSDMD-mediated pyroptosis pathway were elevated in the combined group. This study illustrates that exposure to arsenic, combined with low-dose STZ, not only leads to pancreatic injury in mice, impacting insulin secretion and causing elevated blood glucose levels, thereby hastening the progression of type 1 diabetes, but also induces pyroptosis in pancreatic tissues by influencing the NLRP3/Caspase-1/GSDMD signaling pathway, further facilitating the development of type 1 diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Pyroptosis",
+ "Diabetes Mellitus, Type 1",
+ "Mice",
+ "Arsenic",
+ "Caspase 1",
+ "NLR Family, Pyrin Domain-Containing 3 Protein",
+ "Diabetes Mellitus, Experimental",
+ "Male",
+ "Insulin",
+ "Reactive Oxygen Species",
+ "Blood Glucose",
+ "Streptozocin",
+ "Phosphate-Binding Proteins",
+ "Disease Progression",
+ "Interleukin-18",
+ "Interleukin-1beta",
+ "Pancreas",
+ "Signal Transduction",
+ "Mice, Inbred C57BL",
+ "Insulin Resistance",
+ "Gasdermins"
+ ]
+ },
+ {
+ "PMID": "39675483",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Factors influencing the acceptability of automated insulin delivery systems in youths with type 1 diabetes and their parents.",
+ "Abstract": "Participants receiving SAP therapy demonstrated higher expectations and optimistic views about AIDs. This treatment modality can act as a trampoline to AIDs despite individuals' glucose control and diabetes history.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Female",
+ "Insulin Infusion Systems",
+ "Adolescent",
+ "Parents",
+ "Insulin",
+ "Blood Glucose Self-Monitoring",
+ "Child",
+ "Hypoglycemic Agents",
+ "Patient Acceptance of Health Care",
+ "Surveys and Questionnaires",
+ "Blood Glucose",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39675356",
+ "Title": "Arquivos de neuro-psiquiatria",
+ "ArticleTitle": "Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics.",
+ "Abstract": "\u2003In the present study, we found no association involving the ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Methylenetetrahydrofolate Reductase (NADPH2)",
+ "Female",
+ "Male",
+ "Adolescent",
+ "Child",
+ "Interleukin-4",
+ "Polymorphism, Genetic",
+ "Diabetic Neuropathies",
+ "Diabetes Mellitus, Type 1",
+ "Genotype",
+ "Genetic Predisposition to Disease",
+ "Neural Conduction"
+ ]
+ },
+ {
+ "PMID": "39673446",
+ "Title": "Health technology assessment (Winchester, England)",
+ "ArticleTitle": "Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.",
+ "Abstract": "This award was funded by the National Institute for Health and Care Research (NIHR) Evidence Synthesis programme (NIHR award ref: NIHR133547) and is published in full in ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Cost-Benefit Analysis",
+ "Insulin Infusion Systems",
+ "Blood Glucose Self-Monitoring",
+ "Insulin",
+ "Blood Glucose",
+ "Hypoglycemic Agents",
+ "Models, Economic",
+ "Glycated Hemoglobin",
+ "Quality-Adjusted Life Years",
+ "Randomized Controlled Trials as Topic",
+ "Algorithms"
+ ]
+ },
+ {
+ "PMID": "39673230",
+ "Title": "Internal medicine journal",
+ "ArticleTitle": "Comparison of cardiovascular risk prediction in type 1 diabetes: an Australian viewpoint.",
+ "Abstract": "Cardiovascular disease (CVD) is a significant burden in individuals with type 1 diabetes mellitus (T1DM). Yet the optimal method of CVD risk stratification remains uncertain. We found that the new Australian CVD risk calculator could overestimate risk category compared with the Steno Type 1 Risk Engine and underestimate risk category compared with the new Swedish/Scottish prediction tool, both of which were validated for T1DM. More research is needed to derive a CVD risk assessment pathway for individuals with T1DM in Australia.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Cardiovascular Diseases",
+ "Australia",
+ "Risk Assessment",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Heart Disease Risk Factors",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39670552",
+ "Title": "The American journal of nursing",
+ "ArticleTitle": "Original Research: Exploring the Use of Passive vs. Active Insulin Safety Pen Needle Devices in a Pediatric Population: A Feasibility Study.",
+ "Abstract": "As frontline workers in patient care, nurses can lead the innovation and development of new treatment approaches, protocols, and equipment. This nurse-led study explored the nurses' perceptions about the feasibility of a new active SPN device versus the passive SPN device in terms of safety, ease of use, ease of and confidence in dose administration, and ease of teaching device use to pediatric patients and their caregivers. The RNs' clear preference for the active over the passive SPN device suggests that the newer, active devices warrant more widespread use in hospital settings, with further research also recommended.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Feasibility Studies",
+ "Insulin",
+ "Child",
+ "Female",
+ "Male",
+ "Needlestick Injuries",
+ "Injections, Subcutaneous",
+ "Needles",
+ "Adolescent",
+ "Diabetes Mellitus, Type 1",
+ "Child, Preschool",
+ "Hypoglycemic Agents",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39667114",
+ "Title": "Vaccine",
+ "ArticleTitle": "Seroconversion following PPSV23 vaccination in children with type 1 diabetes mellitus.",
+ "Abstract": "Response to pneumococcal vaccination has not previously been assessed in children with T1DM, and our study demonstrates robust humoral immune response to PPSV23 vaccination in these children. Larger studies with a diverse representation and longer follow up to assess how humoral seroconversion correlates with clinical response to PPSV23 in this vulnerable population are warranted.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Female",
+ "Child",
+ "Prospective Studies",
+ "Pneumococcal Vaccines",
+ "Seroconversion",
+ "Pilot Projects",
+ "Antibodies, Bacterial",
+ "Child, Preschool",
+ "Immunoglobulin G",
+ "Adolescent",
+ "Vaccination",
+ "Pneumococcal Infections",
+ "Glycated Hemoglobin",
+ "Streptococcus pneumoniae"
+ ]
+ },
+ {
+ "PMID": "39666416",
+ "Title": "Medicina",
+ "ArticleTitle": "[Advances in continuous glucose monitoring: evidence of a new generation technology].",
+ "Abstract": "Continuous glucose monitoring (CGM) provides comprehensive and dynamic information to guide the management of diabetes mellitus (DM). This paper summarizes the evidence and implications of the use of the new CGM system, FreeStyle Libre 2 (FSL2). A global review of the literature on the use of FSL2 in people with DM was performed. All types of studies were included. The evidence is presented qualitatively together with expert clinical opinion. FSL2 is an integrated CGM system with real-time glucose readings (no scanning required) and customizable alarms. In studies of subjects aged 2 years and older with DM1 or DM2, the overall mean absolute relative difference for FSL2 was 8.2%, with a high degree of clinical accuracy. Compared to blood monitoring in DM1, studies show higher time within range, lower time below range and lower time above range at 4, 8 and 12 weeks of FSL2 use. These results were confirmed in observational studies in DM, where the majority of FSL2 users reported greater satisfaction with treatment and a significant improvement in quality of life. In concluded, Including the FSL2 system in the management of people with DM would also reduce the risks associated with DM complications, improving the prognosis of this population and allowing for the appropriate use of healthcare resources.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose Self-Monitoring",
+ "Blood Glucose",
+ "Diabetes Mellitus",
+ "Quality of Life",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39665438",
+ "Title": "ACS applied materials & interfaces",
+ "ArticleTitle": "Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted \u03b2 Cells.",
+ "Abstract": "Treating type 1 diabetes (T1D) through \u03b2-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved \u03b2-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of \u03b2-cell encapsulation.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Mice",
+ "Insulin-Secreting Cells",
+ "Diabetes Mellitus, Experimental",
+ "Cell Survival",
+ "Anti-Inflammatory Agents",
+ "Polytetrafluoroethylene",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Macrophages",
+ "Membranes, Artificial",
+ "Mice, Inbred C57BL",
+ "Cell Encapsulation",
+ "Islets of Langerhans Transplantation"
+ ]
+ },
+ {
+ "PMID": "39664107",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Diabetic Neuropathy Is Related to Rhinencephalon Degeneration in Adults With Type 1 Diabetes.",
+ "Abstract": {
+ "b": "Conclusions:",
+ "i": "p",
+ "sup": "3"
+ },
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Diabetes Mellitus, Type 1",
+ "Adult",
+ "Middle Aged",
+ "Diabetic Neuropathies",
+ "Female",
+ "Magnetic Resonance Imaging",
+ "Olfactory Bulb",
+ "Aged",
+ "Young Adult",
+ "Adolescent",
+ "Case-Control Studies",
+ "Smell"
+ ]
+ },
+ {
+ "PMID": "39663236",
+ "Title": "European journal of pediatrics",
+ "ArticleTitle": "Translation, adaptation, and psychometric evaluation of the Quality of Life in a Child's Chronic Disease Questionnaire for the Swedish context.",
+ "Abstract": "\u2022\u00a0The Swedish version of the Quality of Life in a Child's Chronic Disease Questionnaire has two subscales\u00a0compared to the original's five. \u2022\u00a0The instrument may potentially be useful for clinical screening of families who have the greatest need for\u00a0supportive interventions.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "Psychometrics",
+ "Sweden",
+ "Child",
+ "Male",
+ "Female",
+ "Surveys and Questionnaires",
+ "Chronic Disease",
+ "Adolescent",
+ "Reproducibility of Results",
+ "Diabetes Mellitus, Type 1",
+ "Translations",
+ "Asthma",
+ "Parents",
+ "Factor Analysis, Statistical",
+ "Child, Preschool"
+ ]
+ },
+ {
+ "PMID": "39661959",
+ "Title": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
+ "ArticleTitle": "Stability and change of illness identity in Belgian youth with type 1 diabetes: a latent transition analysis.",
+ "Abstract": "The present study informed both theory and clinical practice on how illness identity is experienced by youth with T1D from a person-centered perspective. In addition, the results provided insight into which aspects are meaningfully related to illness identity integration, supporting tailored interventions for youth with T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Adolescent",
+ "Male",
+ "Belgium",
+ "Longitudinal Studies",
+ "Young Adult",
+ "Adult",
+ "Self Concept"
+ ]
+ },
+ {
+ "PMID": "39658973",
+ "Title": "JPMA. The Journal of the Pakistan Medical Association",
+ "ArticleTitle": "Comparison of ketoacidosis in type 1 and 2 diabetic patients with and without concurrent COVID-19 and determining the factors affecting their treatment and survival: a retrospective cohort study.",
+ "Abstract": "Patients of diabetic ketoacidosis with coronavirus disease-2019 had poor survival outcomes compared to diabetic ketoacidosis patients without coronavirus disease-2019.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "COVID-19",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Retrospective Studies",
+ "Pakistan",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Adult",
+ "SARS-CoV-2",
+ "Survival Rate",
+ "Incidence"
+ ]
+ },
+ {
+ "PMID": "39658119",
+ "Title": "Saudi medical journal",
+ "ArticleTitle": "Comparison of pediatric diabetic ketoacidosis in newly diagnosed versus known patients with type 1 diabetes mellitus: A single-center study.",
+ "Abstract": "The DKA incidence was higher in newly diagnosed patients, particularly in the middle-childhood age group. Economic factors may contribute to disease manifestations, and newly diagnosed patients had longer DKA symptom durations. The higher DKA incidence and severity in newly diagnosed patients, particularly in certain age groups, underscores the importance of increased disease awareness and early diagnosis.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "Diabetes Mellitus, Type 1",
+ "Child",
+ "Male",
+ "Female",
+ "Retrospective Studies",
+ "Adolescent",
+ "Saudi Arabia",
+ "Child, Preschool",
+ "Incidence",
+ "Polyuria",
+ "Abdominal Pain",
+ "Polydipsia",
+ "Vomiting",
+ "Age Factors",
+ "Severity of Illness Index"
+ ]
+ },
+ {
+ "PMID": "39658013",
+ "Title": "JMIR formative research",
+ "ArticleTitle": "Improving Self-Efficacy, Quality of Life, and Glycemic Control in Adolescents With Type 1 Diabetes: Randomized Controlled Trial for the Evaluation of the Family-Centered Empowerment Model.",
+ "Abstract": "ClinicalTrials.gov NCT06694467; https://clinicaltrials.gov/study/NCT06694467.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Female",
+ "Male",
+ "Self Efficacy",
+ "Quality of Life",
+ "Jordan",
+ "Glycemic Control",
+ "Empowerment",
+ "Glycated Hemoglobin",
+ "Child"
+ ]
+ },
+ {
+ "PMID": "39653802",
+ "Title": "Diabetologia",
+ "ArticleTitle": "The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD).",
+ "Abstract": "Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provide additional health benefits but can cause glucose fluctuations, which challenges current AID systems. While an increasing number of clinical trials and reviews are being published on different AID systems and PA, it seems prudent at this time to collate this information and develop a position statement on the topic. This joint European Association for the Study of Diabetes (EASD)/International Society for Pediatric and Adolescent Diabetes (ISPAD) position statement reviews current evidence on AID systems and provides detailed clinical practice points for managing PA in children, adolescents and adults with type 1 diabetes using AID technology. It discusses each commercially\u00a0available AID system individually and provides guidance on their use in PA. Additionally, it addresses different glucose responses to PA and provides stratified therapy options to maintain glucose levels within the target ranges for these age groups.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Exercise",
+ "Insulin Infusion Systems",
+ "Insulin",
+ "Adolescent",
+ "Child",
+ "Hypoglycemic Agents",
+ "Europe",
+ "Blood Glucose",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39652325",
+ "Title": "JAMA pediatrics",
+ "ArticleTitle": "New-Onset Type 1 and Type 2 Diabetes Among Korean Youths During the COVID-19 Pandemic.",
+ "Abstract": "These findings suggest that the incidence and severity of T1D and T2D among South Korean youths increased during the COVID-19 pandemic. The cohort analysis does not support SARS-CoV-2 infection itself as being directly associated with incident diabetes.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Male",
+ "Republic of Korea",
+ "Adolescent",
+ "Female",
+ "Child",
+ "Incidence",
+ "Child, Preschool",
+ "Young Adult",
+ "Cohort Studies",
+ "Pandemics",
+ "SARS-CoV-2"
+ ]
+ },
+ {
+ "PMID": "39652177",
+ "Title": "Dermatologie (Heidelberg, Germany)",
+ "ArticleTitle": "[Atopic dermatitis and diabetes mellitus-is there a\u00a0link?].",
+ "Abstract": "Clinicians should be aware of this potential correlation in both adult and pediatric patients and consider the importance of an interdisciplinary approach for the management of atopic dermatitis. Further research is needed to determine possible associations between atopic dermatitis and diabetes mellitus in specific populations.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Dermatitis, Atopic",
+ "Comorbidity",
+ "Risk Factors",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus",
+ "Child",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39649224",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "The harmful effect of ankylosing spondylitis on diabetes mellitus: new evidence from the Mendelian randomization analysis.",
+ "Abstract": "Our findings collectively underscore the detrimental impact of AS on the development of diabetes, highlighting the critical influence of autoimmune disorders in diabetes onset. This provides profound insights into the pathogenesis of diabetes from an immunological standpoint.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Genetic Predisposition to Disease",
+ "Genome-Wide Association Study",
+ "Glycated Hemoglobin",
+ "Mendelian Randomization Analysis",
+ "Polymorphism, Single Nucleotide",
+ "Spondylitis, Ankylosing"
+ ]
+ },
+ {
+ "PMID": "39648458",
+ "Title": "Proteomics",
+ "ArticleTitle": "Reduction of Chemokine CXCL9 Expression by Omega-3 Fatty Acids via ADP-Ribosylhydrolase ARH3 in MIN6 Insulin-Producing Cells.",
+ "Abstract": "Type 1 diabetes (T1D) results from the autoimmune destruction of the insulin-producing \u03b2 cells of the pancreas. Omega-3 fatty acids protect \u03b2 cells and reduce the incidence of T1D, but the mechanism is poorly understood. We have shown that omega-3 fatty acids reduce pro-inflammatory cytokine-mediated \u03b2-cell apoptosis by upregulating the expression of the ADP-ribosylhydrolase ARH3. Here, we further investigate the \u03b2-cell protection mechanism of ARH3 by performing siRNA analysis of its gene Adprhl2 in MIN6 insulin-producing cells, subsequent treatment with a cocktail of the pro-inflammatory cytokines IL-1\u03b2\u00a0+\u00a0IFN-\u03b3\u00a0+\u00a0TNF-\u03b1, followed by proteomics analysis. ARH3 regulated proteins from several pathways related to the nucleus (splicing, RNA surveillance, and nucleocytoplasmic transport), mitochondria (metabolic pathways), and endoplasmic reticulum (protein folding). ARH3 also regulated the levels of proteins related to antigen processing and presentation, and the chemokine-signaling pathway. We further studied the role of ARH3 in regulating the chemokine CXCL9. We found that ARH3 reduces the cytokine-induced expression of CXCL9, which is dependent on omega-3 fatty acids. In conclusion, we demonstrate that omega-3 fatty acids regulate CXCL9 expression via ARH3, which may have a role in protecting \u03b2 cells from immune attack thereby preventing T1D development. Significance of the Study: Omega-3 fatty acids have a variety of health benefits. In type 1 diabetes, omega-3 fatty acids reduce the islet autoimmune response and the disease development. Here, we studied the pathways regulated by the adenosine diphosphate (ADP)-ribosylhydrolase ARH3, a protein whose expression is regulated by omega-3 fatty acids. We showed that ARH3 reduces the expression of chemokines in response to omega-3 fatty acids. This represents an anti-inflammatory mechanism of omega-3 fatty acids that might be involved with protection against type 1 diabetes development.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Fatty Acids, Omega-3",
+ "Chemokine CXCL9",
+ "Insulin-Secreting Cells",
+ "Animals",
+ "Mice",
+ "Diabetes Mellitus, Type 1",
+ "Cell Line",
+ "Signal Transduction"
+ ]
+ },
+ {
+ "PMID": "39645243",
+ "Title": "Expert opinion on investigational drugs",
+ "ArticleTitle": "Drugs stimulating insulin secretion in early clinical development for the treatment of type 1 diabetes: what's new?",
+ "Abstract": "Drugs which enhance insulin secretion in individuals may offer clinical benefits to individuals with type 1 diabetes. However, the lack of beta-cell capacity introduces a challenge without regeneration of insulin-producing cells. Stem cell therapies combined with regulation of islet autoimmunity may offer the best prospect of increased insulin secretion in individuals with T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Hypoglycemic Agents",
+ "Insulin-Secreting Cells",
+ "Animals",
+ "Drug Development",
+ "Insulin Secretion",
+ "Insulin",
+ "Disease Progression",
+ "Glycemic Control"
+ ]
+ },
+ {
+ "PMID": "39644976",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20\u00a0years of \"Diabete Sommerso\u00ae\" experience.",
+ "Abstract": "Data from 1179 dives indicate that, with adherence to the safety protocol, scuba diving is safe and poses no risk of severe hypoglycemia for people with type 1 diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Diving",
+ "Adult",
+ "Hypoglycemia",
+ "Male",
+ "Female",
+ "Blood Glucose",
+ "Young Adult",
+ "Blood Glucose Self-Monitoring",
+ "Glycated Hemoglobin",
+ "Adolescent",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39642862",
+ "Title": "Cell stem cell",
+ "ArticleTitle": "Stem cell islet replacement in type 1 diabetes: From \"shelf\" to \"self\".",
+ "Abstract": "Recently in Cell, Wang and colleagues",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 1",
+ "Humans",
+ "Islets of Langerhans Transplantation",
+ "Induced Pluripotent Stem Cells",
+ "Islets of Langerhans",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39639901",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Health economic evaluation of structured education programs for patients with diabetes: a systematic review.",
+ "Abstract": "This study confirms the cost-effectiveness of structured education programs for diabetes and highlights their importance for patients with type 2 diabetes who have HbA1c levels exceeding 7% and are receiving non-insulin therapy. Additionally, the potential advantages of incorporating telecommunication technologies into structured diabetes education were emphasized. These findings offer valuable insights and guidance for decision-making in diabetes management and clinical practice, contributing to the optimization of medical resource allocation and the improvement of health status and quality of life for patients.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cost-Benefit Analysis",
+ "Diabetes Mellitus, Type 2",
+ "Patient Education as Topic",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39636437",
+ "Title": "Diabetologia",
+ "ArticleTitle": "Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.",
+ "Abstract": "CD226 blockade reduces T cell cytotoxicity and improves Treg function, representing a targeted and rational approach for restoring immune regulation in type 1 diabetes.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "T-Lymphocytes, Regulatory",
+ "Mice, Inbred NOD",
+ "Mice",
+ "Female",
+ "Diabetes Mellitus, Type 1",
+ "Antigens, Differentiation, T-Lymphocyte",
+ "Antibodies, Monoclonal"
+ ]
+ },
+ {
+ "PMID": "39632776",
+ "Title": "Diabetes, obesity & metabolism",
+ "ArticleTitle": "The clinical importance of measuring glycaemic variability: Utilising new metrics to optimise glycaemic control.",
+ "Abstract": "With the widespread use of continuous glucose monitoring (CGM), glycaemic variability (GV) is a glucose metric that has been gaining increasing attention. However, unlike other glucose metrics that are easily defined and have clear targets, GV has a large number of different measures given the complexity involved in assessment. While variabilities in HbA1c, fasting and postprandial glucose have been incorporated under the GV banner, short-term variability in glucose, within day and between days, is more in keeping with the correct definition of GV. This review is focused on short-term GV, as assessed by CGM data, although studies calculating GV from capillary glucose testing are also mentioned as appropriate. The different measures of GV are addressed, and their potential role in microvascular and macrovascular complications, as well as patient-related outcomes, discussed. It should be noted that the independent role of GV in vascular pathology is not always clear, given the inconsistent findings in different populations and the close association between GV and hypoglycaemia, itself an established risk factor for adverse outcomes. Therefore, this review attempts, where possible, to disentangle the contribution of GV to diabetes complications from other glycaemic parameters, particularly hypoglycaemia. Evidence to date strongly suggests an independent role for GV in vascular pathology but future large-scale outcome studies are required to fully understand the exact contribution of this metric to vascular complications. This can be followed by setting appropriate GV measures and targets in different diabetes subgroups, in order to optimise glycaemic management and limit the risk of complications.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose",
+ "Glycemic Control",
+ "Blood Glucose Self-Monitoring",
+ "Hypoglycemia",
+ "Glycated Hemoglobin",
+ "Diabetes Mellitus, Type 2",
+ "Diabetic Angiopathies",
+ "Diabetes Mellitus, Type 1",
+ "Hypoglycemic Agents",
+ "Postprandial Period",
+ "Clinical Relevance"
+ ]
+ },
+ {
+ "PMID": "39632164",
+ "Title": "Archives de pediatrie : organe officiel de la Societe francaise de pediatrie",
+ "ArticleTitle": "Caregiver satisfaction with the use of continuous glucose monitoring and flash glucose monitoring in very young children with type 1 diabetes.",
+ "Abstract": "The vast majority of parents in this group of young children with T1D were satisfied with continuous or flash glucose monitoring. Satisfaction was strongly associated with confidence in the reliability of the device. Reported adverse effects such as skin reaction and difficulties attaching the device highlight the importance of data on real-life use.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose Self-Monitoring",
+ "Female",
+ "Male",
+ "Child, Preschool",
+ "Surveys and Questionnaires",
+ "Infant",
+ "Parents",
+ "Insulin Infusion Systems",
+ "Patient Satisfaction",
+ "Blood Glucose",
+ "Child",
+ "Caregivers",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39629047",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Efficacy and safety of once-weekly insulin versus once-daily insulin in patients with type 1 and type 2 diabetes mellitus: an updated meta-analysis of randomized controlled trials.",
+ "Abstract": "https://www.crd.york.ac.uk/PROSPERO, Identifier CRD42024496812.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Drug Administration Schedule",
+ "Glycated Hemoglobin",
+ "Hypoglycemia",
+ "Hypoglycemic Agents",
+ "Insulin",
+ "Insulin, Long-Acting",
+ "Randomized Controlled Trials as Topic",
+ "Treatment Outcome"
+ ]
+ },
+ {
+ "PMID": "39627081",
+ "Title": "Archives de pediatrie : organe officiel de la Societe francaise de pediatrie",
+ "ArticleTitle": "Impact of early administration of long-acting insulin on ketosis rebound in diabetic ketoacidosis.",
+ "Abstract": "Our study is the first pediatric study suggesting that earlier injection of long-acting insulin after resolution of DKA in children reduces the risk of ketosis rebound.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Ketoacidosis",
+ "Retrospective Studies",
+ "Child",
+ "Female",
+ "Male",
+ "Adolescent",
+ "Child, Preschool",
+ "Infant",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 1",
+ "Insulin, Long-Acting",
+ "Insulin",
+ "Infant, Newborn",
+ "Infusions, Intravenous"
+ ]
+ },
+ {
+ "PMID": "39626097",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes.",
+ "Abstract": "In total, we identified heterogeneity in T1D genetic risk dependent on high-risk HLA-DR3/DR4 haplotype, which uncovers disease mechanisms and enables more accurate prediction of T1D across the HLA background.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "HLA-DR3 Antigen",
+ "Haplotypes",
+ "HLA-DR4 Antigen",
+ "Genetic Predisposition to Disease",
+ "Male",
+ "Female",
+ "Genome-Wide Association Study",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39625868",
+ "Title": "JMIR mHealth and uHealth",
+ "ArticleTitle": "The Role of Smartwatch Technology in the Provision of Care for Type 1 or 2 Diabetes Mellitus or Gestational Diabetes: Systematic Review.",
+ "Abstract": "This systematic review has highlighted the lack of robust randomized clinical trials that explore the efficacy of smartwatch technology in the management of patients with type 1, type 2, and gestational diabetes. Further research is required to establish the role of integrated smartwatch technology in important outcomes such as glycemic control, exercise participation, drug adherence, and diet monitoring in people with all forms of diabetes mellitus.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pregnancy",
+ "Female",
+ "Diabetes, Gestational",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Blood Glucose Self-Monitoring",
+ "Wearable Electronic Devices"
+ ]
+ },
+ {
+ "PMID": "39625848",
+ "Title": "Molecular pharmaceutics",
+ "ArticleTitle": "Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights.",
+ "Abstract": "Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid modalities, including insulin, which could prove to be beneficial for patients with type 1 diabetes mellitus. This work aimed to design and manufacture a hollow MN with an improved insertion and delivery profile suitable for insulin administration. ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Insulin",
+ "Administration, Cutaneous",
+ "Needles",
+ "Drug Delivery Systems",
+ "Animals",
+ "Skin",
+ "Swine",
+ "Skin Absorption",
+ "Microinjections",
+ "Diabetes Mellitus, Type 1",
+ "Hypoglycemic Agents",
+ "Humans"
+ ]
+ },
+ {
+ "PMID": "39625039",
+ "Title": "Annals of the New York Academy of Sciences",
+ "ArticleTitle": "Efficacy and safety of the glucagon receptor antagonist volagidemab in type-1 diabetes: A systematic review and meta-analysis.",
+ "Abstract": "The glucagon receptor antagonist (GRA) volagidemab is the first-in-class fully human monoclonal antibody that inhibits glucagon receptor. GRA can improve glycemia by reducing endogenous glucose production and reduce risks of diabetic ketoacidosis by suppressing ketogenesis. This systematic review and meta-analysis analyzed the efficacy and safety of volagidemab in type-1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) involving T1D patients receiving volagidemab. The primary outcome was to evaluate changes in total daily dose (TDD) of insulin. The secondary outcomes were to evaluate changes in measures of glycemia, hypoglycemia, and adverse events. Data from 3 RCTs (98 patients) were analyzed. Volagidemab (70\u00a0mg/week) was associated with a significant reduction in TDD of insulin requirement (mean difference [MD]: -8.45 units/day (95% confidence interval [CI]: [-12.09, -4.81]); I",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Receptors, Glucagon",
+ "Hypoglycemic Agents",
+ "Blood Glucose",
+ "Insulin",
+ "Randomized Controlled Trials as Topic",
+ "Hypoglycemia",
+ "Treatment Outcome",
+ "Antibodies, Monoclonal, Humanized"
+ ]
+ },
+ {
+ "PMID": "39622650",
+ "Title": "JMIR dermatology",
+ "ArticleTitle": "Cutaneous Adverse Effects From Diabetes Devices in Pediatric Patients With Type 1 Diabetes Mellitus: Systematic Review.",
+ "Abstract": "The dermatologic complications of CGM and CSII pose a potential risk to long-term glycemic control in T1D, especially in young patients where skin lesions can lead to discontinuation. Increased manufacturer transparency is critical and further studies are needed to expand upon the current preventative measures such as device site rotation and steroid creams, which lack consistent effectiveness.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Child",
+ "Blood Glucose Self-Monitoring",
+ "Insulin Infusion Systems",
+ "Adolescent",
+ "Insulin",
+ "Skin Diseases",
+ "Hypoglycemic Agents",
+ "Child, Preschool",
+ "Lipodystrophy",
+ "Dermatitis, Contact"
+ ]
+ },
+ {
+ "PMID": "39622257",
+ "Title": "The lancet. Diabetes & endocrinology",
+ "ArticleTitle": "Treatment regimens and glycaemic outcomes in more than 100\u2009000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from paediatric diabetes registries.",
+ "Abstract": "For the Norwegian, German, Czech, Danish and Swedish translations of the abstract see Supplementary Materials section.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Registries",
+ "Child",
+ "Female",
+ "Male",
+ "Longitudinal Studies",
+ "Adolescent",
+ "Child, Preschool",
+ "Glycated Hemoglobin",
+ "Hypoglycemic Agents",
+ "Blood Glucose",
+ "Hypoglycemia",
+ "Treatment Outcome",
+ "Infant",
+ "Glycemic Control"
+ ]
+ },
+ {
+ "PMID": "39622163",
+ "Title": "Biofabrication",
+ "ArticleTitle": "Engineering pore-enriched and pre-vascularized volumetric constructs for enhanced blood glucose regulation in type 1 diabetes therapy.",
+ "Abstract": "Managing type 1 diabetes mellitus (T1DM) presents significant challenges because of the complexity of replicating the microenvironment of pancreatic islets and ensuring the long-term viability and function of transplanted insulin-producing cells (IPCs). This study developed a functional approach that utilizes 3D bioprinting technology to create pore-enriched and pre-vascularized tissue constructs incorporating a pancreatic tissue-derived decellularized extracellular matrix and human-induced pluripotent stem cells (hiPSCs) aimed at enhancing blood glucose regulation in T1DM. We designed a volumetric 3D pancreatic tissue construct that supported the engraftment, survival, and insulin-producing functionality of hiPSC-derived IPCs. The construct's porosity was optimized to enhance IPC delivery efficiency. Additionally, human umbilical vein endothelial cells co-cultured with IPCs in a patterned structure facilitated pre-vascularization, improving construct integration with host tissues and accelerating revascularization post-transplantation. Our results demonstrate high cell viability and sustained insulin production in diabetic rodent models, indicating the constructs' effectiveness in regulating blood glucose levels over an extended period. The findings of this study not only underscore the potential of 3D bioprinting for creating functional tissue constructs for T1DM treatment but also offer efficient cell delivery techniques applicable to other areas of regenerative medicine.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 1",
+ "Humans",
+ "Animals",
+ "Blood Glucose",
+ "Tissue Engineering",
+ "Porosity",
+ "Human Umbilical Vein Endothelial Cells",
+ "Tissue Scaffolds",
+ "Induced Pluripotent Stem Cells",
+ "Insulin",
+ "Diabetes Mellitus, Experimental",
+ "Printing, Three-Dimensional",
+ "Bioprinting",
+ "Male",
+ "Cell Survival",
+ "Insulin-Secreting Cells",
+ "Extracellular Matrix"
+ ]
+ },
+ {
+ "PMID": "39621933",
+ "Title": "Diabetes care",
+ "ArticleTitle": "Continuous Glucose Monitor Accuracy for Diabetes Management in Hospitalized Children.",
+ "Abstract": "CGMs demonstrated acceptable accuracy in hospitalized children with diabetes. CGM data should be integrated into hospital electronic records to optimize management.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Child",
+ "Adolescent",
+ "Child, Preschool",
+ "Retrospective Studies",
+ "Female",
+ "Blood Glucose",
+ "Male",
+ "Blood Glucose Self-Monitoring",
+ "Diabetes Mellitus",
+ "Hospitalization",
+ "Diabetes Mellitus, Type 1"
+ ]
+ },
+ {
+ "PMID": "39621313",
+ "Title": "The Journal of clinical investigation",
+ "ArticleTitle": "Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice.",
+ "Abstract": "Type 1 diabetes (T1D) develops spontaneously despite functional antigen presentation machinery in the thymus and a perceptible central tolerance process. We found that intrathymic enrichment with IL-4 fine tunes signaling through the IL-4/IL-13 heteroreceptor (HR) in early thymic progenitors (ETPs), augments negative selection of self-reactive T cells, sustains a diverse T cell repertoire devoid of clones expressing disease-associated T cell receptor (TCR) genes, and protects the nonobese diabetic (NOD) mouse from T1D. Indeed, optimal IL-4 activates STAT transcription factors to program ETP fate decision toward CD11c+CD8\u03b1+ dendritic cells (DCs) agile in negative T cell selection and clonal deletion of diabetogenic T cells. However, due to diminished invariant natural killer T (iNKT) 2 cell frequency in the NOD thymus, IL-4 is as suboptimal level, metering STAT activation to program ETP fate decision toward the T cell lineage leading to diminished negative selection, a clonally restricted TCR repertoire, and manifestation of spontaneous T1D. These insights uncover yet another interplay by which IL-4 affects T1D.",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Mice, Inbred NOD",
+ "Interleukin-4",
+ "Mice",
+ "Thymus Gland",
+ "Diabetes Mellitus, Type 1",
+ "Receptors, Antigen, T-Cell",
+ "Dendritic Cells",
+ "Natural Killer T-Cells"
+ ]
+ },
+ {
+ "PMID": "39620918",
+ "Title": "Diabetes technology & therapeutics",
+ "ArticleTitle": "Automated Insulin Delivery Effects During Driving Among Older Adults with Type 1 Diabetes in a Randomized Trial.",
+ "Abstract": "Dysglycemia among drivers with type 1 diabetes (T1D) is associated with impaired driving performance, and glucose levels \"above 5 to drive\" are often recommended for insulin-treated drivers. Evidence for diabetes treatments that support euglycemia while driving is minimal, particularly for older drivers. In this randomized, crossover trial involving adults aged \u226560 years with T1D, we used continuous glucose monitoring (CGM) during driving to compare the first-generation closed-loop automated insulin delivery (AID) versus a sensor-augmented pump therapy. There were 1894 trips undertaken by 8 drivers (median age 68 years [IQR: 64-70]). During AID versus sensor-augmented pump, time in range >5.0-10.0 mmol/L was greater (100% [0-100] vs. 81% [0-100]; ",
+ "Predictions": [
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Aged",
+ "Automobile Driving",
+ "Insulin Infusion Systems",
+ "Male",
+ "Female",
+ "Insulin",
+ "Cross-Over Studies",
+ "Hypoglycemic Agents",
+ "Middle Aged",
+ "Blood Glucose",
+ "Blood Glucose Self-Monitoring"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/diabetes_type_2.json b/model/dataset/diabetes_type_2.json
new file mode 100644
index 0000000000000000000000000000000000000000..d12573feb390116e7fdca3a327c67a6fd0ba8d46
--- /dev/null
+++ b/model/dataset/diabetes_type_2.json
@@ -0,0 +1,2462 @@
+[
+ {
+ "PMID": "39738226",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Excessive daytime sleepiness and its predictors among type 2 diabetes mellitus patients at central ethiopia.",
+ "Abstract": "Excessive daytime sleepiness is a common finding among type 2 diabetes mellitus patients. However there is scarce data that shows the magnitude of excessive daytime sleepiness, & its association with type 2 diabetes mellitus. Hence, the study aimed to assess the prevalence of excessive daytime sleepiness and its associated factors among type 2 diabetes mellitus patients at Wolkite University Specialized Hospital. A Hospital-based cross-sectional study was employed from January 15 to March 15, 2022, among 229 Type 2 diabetes mellitus patients. Data was collected by semi-structured questionnaires, then entered into the Epi data version 4.6 and exported to SPSS version 25.0 for analysis. Binary and multiple logistic regression analysis was used to assess factors associated with excessive daytime sleepiness and statistical significance was set at P-value\u2009<\u20090.05. The prevalence of Excessive daytime sleepiness among type 2 diabetes mellitus was 27.1%. Age (AOR: 1.08; 95%CI: 1.03, 1.12), frequent snoring (AOR: 2.9; 95%CI: 1.24, 6.80), comorbid hypertension (AOR: 2.64; 95%CI: 1.17, 5.96), obesity (AOR: 2.7; 95%CI: 1.03, 7.13), and poor glycemic control (AOR: 6.68; 95%CI: 1.83, 24.41) were independently associated with Excessive daytime sleepiness among type 2 diabetes mellitus patients. Excessive daytime sleepiness was reported in more than a quarter of type 2 diabetes mellitus patients. Age, frequent snoring, hypertension, obesity, and poor glycemic control were significantly associated with Excessive daytime sleepiness among type 2 diabetes mellitus patients. Therefore health care providers should assess not only for how well their patients' diabetes is controlled but also for excessive daytime sleepiness.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Ethiopia",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Disorders of Excessive Somnolence",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Prevalence",
+ "Risk Factors",
+ "Aged",
+ "Hypertension",
+ "Surveys and Questionnaires",
+ "Comorbidity",
+ "Obesity",
+ "Snoring"
+ ]
+ },
+ {
+ "PMID": "39737893",
+ "Title": "Nutrition & diabetes",
+ "ArticleTitle": "The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.",
+ "Abstract": "There is an association between diabetes and arthritis, with potential genetic links between Type 1 Diabetes and RA.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mendelian Randomization Analysis",
+ "Male",
+ "Female",
+ "Nutrition Surveys",
+ "Middle Aged",
+ "Genome-Wide Association Study",
+ "Arthritis, Rheumatoid",
+ "Adult",
+ "Arthritis",
+ "Prevalence",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Aged",
+ "Genetic Predisposition to Disease",
+ "Logistic Models",
+ "Polymorphism, Single Nucleotide"
+ ]
+ },
+ {
+ "PMID": "39737509",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "ICMR-MDRF Diabetes Biosamples: Cohort profile.",
+ "Abstract": "Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR). The ICMR-INDIAB study is the largest epidemiological study on diabetes in India, encompassing a nationally representative sample of individuals aged 20 yr and older from urban and rural areas in every State across the country. The ICMR-YDR is the first national-level, multicentric clinic-based registry focusing on youth-onset diabetes in India, aiming to understand the disease patterns and variations in youth-onset diabetes across different country regions. Results Key operations at the MDRF biobank include collecting and processing samples, where serum and whole blood samples are aliquoted and transferred through a cold chain to the central laboratory, and then stored in Siruseri (29 km from the capital city of Chennai, Tamil Nadu). Samples are barcoded, linked to subject information, and stored in freezers or liquid nitrogen (LN2) vessels, with inventory tracked via software for easy retrieval. A register records access to the biobank, ensuring sample integrity and compliance with regulatory requirements. The biobank adheres to the ICMR's National Ethical Guidelines for Biomedical and Health Research involving human participants. Interpretation & conclusions The biobank enables the analysis of biomarkers in stored samples, aiding in scientifically sound decisions, treating patients, and potentially curing diabetes.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Biological Specimen Banks",
+ "Adult",
+ "Female",
+ "Male",
+ "Diabetes Mellitus",
+ "Registries",
+ "Biomedical Research",
+ "Young Adult",
+ "Cohort Studies",
+ "Age of Onset",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39736941",
+ "Title": "Archives of Razi Institute",
+ "ArticleTitle": "Involvement of \u03b3-Aminobutyric Acid and N-methyl-D-aspartate Receptors in Diabetic Gastropathy in Rats: Possible Beneficial Effect of Prolonged Treatment with Insulin and Magnesium Supplement.",
+ "Abstract": "Gastrointestinal dysfunction is a severe and common complication in diabetic patients. Some evidence shows that gamma-aminobutyric acid (GABA) and glutamate contribute to diabetic gastrointestinal abnormalities. Therefore, we examined the impact of prolonged treatment with insulin and magnesium supplements on the expression pattern of GABA type A (GABA-A), GABA-B, and N-methyl-D-aspartate (NMDA) glutamate receptors as well as nitric oxide synthase 1 (NOS-1) in the stomach of type 2 diabetic rats. Twenty-four male Wistar rats were randomized to four groups (six rats each): 1) control, 2) type 2 diabetes: rats fed with a high-fat diet for three months + a low dose of streptozotocin (35 mg/kg), 3) type 2 diabetes + magnesium, and 4) type 2 diabetes + insulin. The expression of NOS-1, GABA-A, GABA-B, and NMDA receptors was detected using western blotting. The NOS-1 expression was substantially diminished (P<0.01), while the expression of GABA-A (P<0.001), GABA-B (P<0.001), and NMDA (P<0.001) receptors was enhanced in the stomach of diabetic rats relative to control. Treatment with magnesium and insulin improved NOS-1 expression in diabetic rats, although this effect was greater in magnesium treatment alone. Magnesium also restored the expression of GABA-A and GABA-B receptors in diabetic rats to control values. Moreover, insulin treatment improved GABA-A receptor expression in diabetic rats (P<0.05). No considerable alterations were detected in NMDA receptor levels in the treatment groups. The results suggest a significant role of magnesium and insulin in improving gastric motility and secretory disorders associated with diabetes through modifying the expression of GABAergic receptors.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Male",
+ "Rats, Wistar",
+ "Receptors, N-Methyl-D-Aspartate",
+ "Diabetes Mellitus, Experimental",
+ "Insulin",
+ "Rats",
+ "Magnesium",
+ "Diabetes Mellitus, Type 2",
+ "Nitric Oxide Synthase Type I",
+ "Dietary Supplements",
+ "Random Allocation",
+ "Streptozocin"
+ ]
+ },
+ {
+ "PMID": "39736870",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Construction and validation of a nomogram model for predicting diabetic peripheral neuropathy.",
+ "Abstract": "The DPN nomogram prediction model, containing 7 significant variables, has exhibited excellent performance. Its generalization to clinical practice could potentially help in the early detection and prompt intervention for high-risk DPN patients.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Nomograms",
+ "Diabetic Neuropathies",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Aged",
+ "Risk Factors",
+ "ROC Curve",
+ "Diabetes Mellitus, Type 2",
+ "Prognosis",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39736865",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus - an exploratory study.",
+ "Abstract": "Both T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Ultrasonography",
+ "Aged",
+ "Middle Aged",
+ "Bone Density",
+ "Diabetes Mellitus, Type 2",
+ "Tibia",
+ "Absorptiometry, Photon",
+ "Case-Control Studies",
+ "Diabetes Mellitus, Type 1",
+ "Cortical Bone",
+ "Elasticity"
+ ]
+ },
+ {
+ "PMID": "39736861",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism.",
+ "Abstract": "A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone tests, leading to a diagnosis of primary bilateral macronodular adrenal hyperplasia. Concurrently, elevated blood calcium and parathyroid hormone levels, along with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) imaging revealing increased 99mTc-MIBI uptake in the right inferior parathyroid gland, suggest the consideration of primary hyperparathyroidism. This case is presented in light of the uncommon clinical coexistence of primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Middle Aged",
+ "Hyperparathyroidism, Primary",
+ "Adrenal Glands",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39736858",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Association of oxidative balance score with cardiovascular disease and all-cause and cardiovascular mortality in American adults with type 2 diabetes: data from the National Health and Nutrition examination survey 1999-2018.",
+ "Abstract": "Adherence to higher OBS was associated with reduced CVD prevalence and mortality risk in T2D. Antioxidant diet and lifestyle had more significant associations with mortality and CVD prevalence, respectively. However, as these findings are merely associations and do not allow causal inferences to be drawn, future validation in high-quality randomized controlled trials is needed.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "Adult",
+ "Oxidative Stress",
+ "United States",
+ "Aged",
+ "Life Style",
+ "Diet",
+ "Risk Factors",
+ "Follow-Up Studies",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39736551",
+ "Title": "BMC primary care",
+ "ArticleTitle": "The moderating role of e-health literacy and patient-physician communication in the relationship between online diabetes information-seeking behavior and self-care practices among individuals with type 2 diabetes.",
+ "Abstract": "Findings support the role of patient eHL and patient-physician communication in amplifying the positive impact of online DISB on patients' behavioral outcomes in diabetes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Health Literacy",
+ "Physician-Patient Relations",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Self Care",
+ "Information Seeking Behavior",
+ "Medication Adherence",
+ "Communication",
+ "Aged",
+ "Adult",
+ "Internet",
+ "Assessment of Medication Adherence"
+ ]
+ },
+ {
+ "PMID": "39736518",
+ "Title": "BMC cardiovascular disorders",
+ "ArticleTitle": "Effect of sodium glucose cotransporter-2 inhibitors (SGLT-2is) on the clinical outcomes of patients with diabetic atrial fibrillation.",
+ "Abstract": "In our study, SGLT-2i treatment was associated with a significant reduction in all-cause mortality and major bleeding in diabetic AF patients. Our study provides evidence of the clinical benefit of SGLT-2i in AF patients.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Male",
+ "Atrial Fibrillation",
+ "Retrospective Studies",
+ "Female",
+ "Aged",
+ "Treatment Outcome",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Time Factors",
+ "Risk Factors",
+ "Risk Assessment",
+ "Hemorrhage",
+ "Aged, 80 and over",
+ "Cause of Death",
+ "Myocardial Infarction"
+ ]
+ },
+ {
+ "PMID": "39736351",
+ "Title": "Life sciences",
+ "ArticleTitle": "AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse.",
+ "Abstract": "In conclusion, we have developed a novel strategy for producing long-acting FGF21 using the AAV vector, and AAV2-ABD-FGF21 shows promise as a therapeutic approach for type 2 diabetes mellitus and other glycolipid metabolic disorders.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Fibroblast Growth Factors",
+ "Diabetes Mellitus, Type 2",
+ "Mice",
+ "Dependovirus",
+ "Humans",
+ "Gene Transfer Techniques",
+ "Genetic Therapy",
+ "Male",
+ "Diabetes Mellitus, Experimental",
+ "HEK293 Cells",
+ "Mice, Inbred C57BL",
+ "Blood Glucose",
+ "Genetic Vectors",
+ "Liver",
+ "Hypoglycemic Agents"
+ ]
+ },
+ {
+ "PMID": "39736334",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets.",
+ "Abstract": "Adhered to a balanced diet is associated with a lower risk of diabetes compared to plant-based diet, which might be attributed to signature proteins such as AGR2, DBI, IL17RA and SERPINH1.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Cross-Sectional Studies",
+ "Diet, Vegetarian",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Prospective Studies",
+ "Aged",
+ "Risk Factors",
+ "United Kingdom",
+ "Proteomics",
+ "Diet, Healthy",
+ "Diet, Plant-Based"
+ ]
+ },
+ {
+ "PMID": "39736162",
+ "Title": "West African journal of medicine",
+ "ArticleTitle": "The Impact of Diabetes Self-Management Education (DSME) on the Quality of Life of patients living with type-2 Diabetes Mellitus in Nigeria.",
+ "Abstract": "The findings highlight that DSME significantly enhances the QoL, self-management competence, and glycemic control among T2DM patients in Nigeria. These results underscore the importance of structured educational interventions in diabetes care, particularly in resource-limited settings.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Quality of Life",
+ "Nigeria",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Self-Management",
+ "Patient Education as Topic",
+ "Adult",
+ "Surveys and Questionnaires",
+ "Health Knowledge, Attitudes, Practice",
+ "Aged",
+ "Self Care"
+ ]
+ },
+ {
+ "PMID": "39735994",
+ "Title": "Frontiers in bioscience (Landmark edition)",
+ "ArticleTitle": "The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples.",
+ "Abstract": "The study demonstrates a decrease in ",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Receptor, ErbB-4",
+ "Neuregulins",
+ "Liver",
+ "Middle Aged",
+ "Female",
+ "Non-alcoholic Fatty Liver Disease",
+ "Male",
+ "Adult",
+ "Lipogenesis",
+ "Obesity",
+ "Diabetes Mellitus, Type 2",
+ "RNA, Messenger",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39735781",
+ "Title": "Experimental biology and medicine (Maywood, N.J.)",
+ "ArticleTitle": "Increased hip fracture risk in the patients with type 2 diabetes mellitus is correlated with urine albumin-to-creatinine ratio (ACR) and diabetes duration in men.",
+ "Abstract": "Patients with type 2 diabetes mellitus (T2DM) have increased hip fracture risk. And the association between urine albumin to creatinine ratio (ACR) and an increased risk of hip fracture in patients with T2DM remains controversial. This study aimed to investigate the association between urinary ACR and hip fracture risk in postmenopausal women and aged men with T2DM. The study included 219 postmenopausal women and 216 older men (mean age >60\u00a0years) with T2DM. Women and men were divided into control group (ACR<30\u00a0mg/g), microalbuminuria group (30\u00a0mg/g \u2264 ACR<300\u00a0mg/g), and macroalbuminuria group (ACR\u2265300\u00a0mg/g) respectively. Demographic characteristics and clinical history were collected in patients. Biochemical indexes and bone turnover-related markers were measured in patients. In the study, we found that several factors, including age, T2DM duration, cerebral infarction history, serum corrected calcium levels and urine ACR were positively associated with hip fracture risk. However, 25-Hydroxyvitamin D and areal BMD were negatively associated with hip fracture risk. Furthermore, multiple regression analysis showed that urinary ACR level (\u03b2 = 0.003, p = 0.044) and duration of T2DM (\u03b2 = 0.015, p = 0.018) were positively and independently correlated with hip fracture risk in older men. In contrast, femoral neck BMD (\u03b2 = -6.765, p < 0.001) was independently and negatively correlated with hip fracture risk in older men. This study indicated that the elevated ACR levels and longer T2DM duration were related to higher hip fracture risk in older men with T2DM, which could be beneficial for developing a predictive model for osteoporotic fractures in patients with type 2 diabetes in the future. However, results were inconsistent in women, hip fracture risk didn't alter by changes in urinary microalbuminuria level in postmenopausal women with T2DM.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Hip Fractures",
+ "Male",
+ "Female",
+ "Albuminuria",
+ "Aged",
+ "Middle Aged",
+ "Creatinine",
+ "Risk Factors",
+ "Bone Density",
+ "Postmenopause"
+ ]
+ },
+ {
+ "PMID": "39735651",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Association between changes in thyroid hormones and incident type 2 diabetes using joint models of longitudinal and time-to-event data: more than a decade follow up in the Tehran thyroid study.",
+ "Abstract": "The findings of this study suggest that dynamic changes in serum thyroid hormones are associated with the development of T2DM. Rising TSH and decreasing FT4 over time are associated with a lower risk of diabetes. These findings suggest a complex interplay between thyroid function and the risk of T2DM, emphasizing the importance of monitoring thyroid hormone levels as a part of T2DM prevention strategies.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Iran",
+ "Middle Aged",
+ "Follow-Up Studies",
+ "Incidence",
+ "Adult",
+ "Thyrotropin",
+ "Thyroxine",
+ "Longitudinal Studies",
+ "Thyroid Hormones",
+ "Risk Factors",
+ "Thyroid Function Tests",
+ "Thyroid Gland",
+ "Thyroid Diseases"
+ ]
+ },
+ {
+ "PMID": "39735647",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "The role of fecal microbiota transplantation in type 2 diabetes mellitus treatment.",
+ "Abstract": "In contemporary microbial research, the exploration of interactions between microorganisms and multicellular hosts constitutes a burgeoning field. The gut microbiota is increasingly acknowledged as a pivotal contributor to various disorders within the endocrine system, encompassing conditions such as diabetes and thyroid diseases. A surge in research activities has been witnessed in recent years, elucidating the intricate interplay between the gut microbiota and disorders of the endocrine system. Simultaneously, fecal microbiota transplantation (FMT) has emerged as a focal point, garnering substantial attention in both biomedical and clinical spheres. Research endeavors have uncovered the remarkable therapeutic efficacy of FMT across diverse diseases, with particular emphasis on its application in addressing type 2 diabetes mellitus (T2DM) and associated com-plications. Consequently, this manuscript accentuates the intimate connection between the gut microbiota and disorders within the endocrine system, with a specific focus on exploring the potential of FMT as an intervention in the therapeutic landscape of T2DM and its complications. Furthermore, the article scrutinizes concerns inherent in treatment modalities centered around the gut microbiota, proposing viable solutions to address these issues.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Fecal Microbiota Transplantation",
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Gastrointestinal Microbiome",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39735646",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Pasireotide-induced hyperglycemia in Cushing's disease and Acromegaly: A clinical perspective and algorithms proposal.",
+ "Abstract": "Pasireotide is an effective treatment for both Cushing's disease (CD) and acromegaly due to its ability to suppress adrenocorticotropic hormone and growth hormone, and to normalize insulin-like growth factor-1 levels, resulting in tumor shrinkage. However, it may also cause hyperglycemia as a side effect in some patients. The aim of this study was to review previous recommendations regarding the management of pasireotide-induced hyperglycemia in patients with CD and acromegaly and to propose efficient monitoring and treatment algorithms based on recent evidence and current guidelines for type 2 diabetes treatment. In about 25% of patients with CD and 50% of patients with acromegaly, pasireotide-induced hyperglycemia does not require drug therapy or can be managed with diet and oral antidiabetic agents. The risk of pasireotide-induced hyperglycemia is higher in patients with diabetes or prediabetes at baseline. Moreover, pasireotide used in the treatment of CD may lead to more frequent and difficult-to-treat glycemic disorders than those observed in acromegaly. Based on the pathomechanism of hyperglycemia, we suggest using metformin as the first-line therapy, followed by glucagon-like peptide-1 and/or sodium-glucose co-transporter-2 inhibitor, and finally insulin in patients with pasireotide-induced hyperglycemia. We propose algorithms for the management of glucose metabolic disorders caused by pasireotide treatment in patients with CD and acromegaly, including those with chronic kidney disease and at high cardiovascular risk.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Somatostatin",
+ "Acromegaly",
+ "Pituitary ACTH Hypersecretion",
+ "Hyperglycemia",
+ "Algorithms",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39735639",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Association of circulating adiponectin and leptin levels with the risk of diabetic peripheral neuropathy.",
+ "Abstract": "Circulating adiponectin and leptin levels correlate with DPN risk in diabetic patients, suggesting their potential as biomarkers for high-risk DPN identification and guiding targeted prevention and management.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adiponectin",
+ "Leptin",
+ "Diabetic Neuropathies",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Case-Control Studies",
+ "Diabetes Mellitus, Type 2",
+ "Aged",
+ "Biomarkers",
+ "Risk Factors",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39735416",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Age Characteristics of Patients With Type 2 Diabetic Foot Ulcers and Predictive Risk Factors for Lower Limb Amputation: A Population-Based Retrospective Study.",
+ "Abstract": {
+ "b": "Conclusion:"
+ },
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Foot",
+ "Amputation, Surgical",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Risk Factors",
+ "Aged",
+ "Diabetes Mellitus, Type 2",
+ "Retrospective Studies",
+ "Lower Extremity",
+ "Age Factors",
+ "China",
+ "Adult",
+ "Prevalence",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39735415",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Metabolomic Profiling Reveals Biomarkers in Coronary Heart Disease Comorbidity.",
+ "Abstract": {
+ "b": "Conclusion:"
+ },
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Metabolomics",
+ "Middle Aged",
+ "Coronary Disease",
+ "Biomarkers",
+ "Diabetes Mellitus, Type 2",
+ "Comorbidity",
+ "Depression",
+ "Hypertension",
+ "Aged",
+ "Gas Chromatography-Mass Spectrometry",
+ "Metabolome",
+ "Adult",
+ "Case-Control Studies"
+ ]
+ },
+ {
+ "PMID": "39735414",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Olfactory Dysfunction as a Biomarker for Early Diagnosis of Cognitive Impairment in Patients With Type 2 Diabetes: A Systematic Review.",
+ "Abstract": {
+ "b": "Conclusions:"
+ },
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Cognitive Dysfunction",
+ "Olfaction Disorders",
+ "Early Diagnosis",
+ "Biomarkers",
+ "Smell",
+ "Magnetic Resonance Imaging",
+ "Brain"
+ ]
+ },
+ {
+ "PMID": "39734182",
+ "Title": "Journal of orthopaedic surgery and research",
+ "ArticleTitle": "A novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction.",
+ "Abstract": "TPD surgery technique is a simple procedure that significantly increases the efficacy and reduces the complications of moderate diabetic foot ulcer patients, which could accelerate the formation of collateral circulation.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Foot",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Aged",
+ "Aged, 80 and over",
+ "Tibia",
+ "Periosteum",
+ "Microcirculation",
+ "Treatment Outcome",
+ "Follow-Up Studies",
+ "Wound Healing",
+ "Diabetes Mellitus, Type 2",
+ "Severity of Illness Index"
+ ]
+ },
+ {
+ "PMID": "39733376",
+ "Title": "Orvosi hetilap",
+ "ArticleTitle": "[Analysis of laboratory tests in adults with diabetes in Hungary].",
+ "Abstract": "",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hungary",
+ "Male",
+ "Female",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Adult",
+ "Diabetes Mellitus",
+ "Blood Glucose",
+ "Glycated Hemoglobin",
+ "Aged",
+ "Clinical Laboratory Techniques",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39733138",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.",
+ "Abstract": "Lines of evidence have indicated that type 2 diabetes mellitus (T2DM) is an independent risk factor for osteoarthritis (OA) progression. However, the study focused on the relationship between T2DM and OA at the transcriptional level remains empty. We downloaded OA- and T2DM-related bulk RNA-sequencing and single-cell RNA sequencing data from the Gene Expression Omnibus (GEO) dataset. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to screen out hub genes between OA and T2DM, and functional enrichment was done. Single-cell sequencing analysis was further used to screen key genes on OA and T2DM datasets. Rat chondrocytes and human articular cartilage were used to validate biomarkers among OA and T2DM. Sixty-eight hub genes were obtained, which were mainly enriched in the inflammatory response. We found that the hub gene TNFAIP6 is not only closely related to OA and T2DM but also a marker of prehypertrophic chondrocytes, which are closely related to the progression of OA. TNFAIP6 was found to be significantly elevated in CD14\u2009+\u2009monocytes in T2DM patients, and this group of cells can promote inflammation. Validation on rat chondrocytes and human cartilage showed that TNFAIP6 was highly expressed in OA and further increased in the presence of T2DM or high glucose. Our study identified several characteristic modules and hub genes in the pathogenesis of T2DM-induced OA, which may facilitate further investigation of its molecular mechanisms. Up-regulated TNFAIP6 may contribute to OA in patients with T2DM by the recruitment of pro-inflammatory CD14\u2009+\u2009monocytes in the OA synovium, which provides a potential target for the diagnosis and treatment of T2DM-associated OA.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Diabetes Mellitus, Type 2",
+ "Humans",
+ "Osteoarthritis",
+ "Animals",
+ "Rats",
+ "Chondrocytes",
+ "Cartilage, Articular",
+ "Up-Regulation",
+ "Lipopolysaccharide Receptors",
+ "Male",
+ "Monocytes",
+ "Gene Expression Profiling",
+ "Biomarkers",
+ "Cell Adhesion Molecules"
+ ]
+ },
+ {
+ "PMID": "39733115",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Dynamic modeling of the Insulin-Glucose-Glucocorticoid impulsive control system.",
+ "Abstract": "This paper introduces a class of insulin-glucose-glucocorticoid impulsive systems in the treatment of patients with diabetes to consider the effect of glucocorticoids. The existence and uniqueness of the positive periodic solution of the impulsive model at double fixed time is confirmed for type 1 diabetes mellitus (T1DM) using the [Formula: see text] function. Further, the global asymptotic stability of the positive periodic solution is achieved following Floquet multiplier theory and comparison principle. Additionally, the permanence of the system is confirmed in type 2 diabetes mellitus (T2DM) via the comparison theorem. Numerical analysis verifies the results of theoretical calculations and indicates that combining therapeutic strategies under hormonal interactions with the dose of exogenous insulin and glucocorticoid medicines within organisms provides more reasonable clinical strategies.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Insulin",
+ "Glucocorticoids",
+ "Diabetes Mellitus, Type 2",
+ "Diabetes Mellitus, Type 1",
+ "Glucose",
+ "Blood Glucose",
+ "Models, Biological"
+ ]
+ },
+ {
+ "PMID": "39733102",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Monocytes to Apolipoprotein A1 ratio is associated with metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus.",
+ "Abstract": "The monocyte-to-Apolipoprotein A1 ratio (MAR) emerges as a potentially valuable inflammatory biomarker indicative of metabolic dysfunction-associated fatty liver disease (MASLD). Accordingly, this investigation primarily aims to assess the correlation between MAR and MASLD risk. A cohort comprising 957 individuals diagnosed with type 2 diabetes mellitus (T2DM) participated in this study. The relationship between MAR and MASLD was analyzed through binomial logistic regression analysis and restricted cubic splines (RCS). Furthermore, a comparative assessment of MAR and monocyte to high-density lipoprotein ratio (MHR) in identifying MASLD efficacy was conducted using receiver operating characteristic curve analysis. Remarkably, even after adjusting for metabolic parameters and hepatic functional markers, MAR stood out as an independent predictor for MASLD (OR 1.58, 95% CI 1.36-1.84; P\u2009<\u20090.001) and displayed a nonlinear positive association with MASLD risk according to RCS analysis (P for nonlinearity and overall\u2009<\u20090.001). Notably, MAR exhibited superior diagnostic accuracy for identifying MASLD compared to MHR (AUC: 0.772 vs 0.722, P\u2009<\u20090.001). In summary, MAR emerges as a promising inflammatory indicator for MASLD, demonstrating potential as a valuable screening tool to bolster the management of MASLD within the T2DM population.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Monocytes",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Apolipoprotein A-I",
+ "Biomarkers",
+ "Aged",
+ "ROC Curve",
+ "Non-alcoholic Fatty Liver Disease"
+ ]
+ },
+ {
+ "PMID": "39732300",
+ "Title": "Journal of ethnopharmacology",
+ "ArticleTitle": "Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.",
+ "Abstract": "Our findings demonstrated that GQD ameliorated liver injury in T2DM by inhibiting ferroptosis through the modulation of Nrf2.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Ferroptosis",
+ "NF-E2-Related Factor 2",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Drugs, Chinese Herbal",
+ "Mice",
+ "Diabetes Mellitus, Experimental",
+ "Mice, Inbred C57BL",
+ "Oxidative Stress",
+ "Liver",
+ "Diet, High-Fat",
+ "Lipid Peroxidation",
+ "Berberine",
+ "Cell Line",
+ "Glucosides",
+ "Flavanones",
+ "Streptozocin",
+ "Isoflavones",
+ "Flavonoids"
+ ]
+ },
+ {
+ "PMID": "39731787",
+ "Title": "European journal of medicinal chemistry",
+ "ArticleTitle": "Corosolic acid and its derivatives targeting MCCC1 against insulin resistance and their hypoglycemic effect on type 2 diabetic mice.",
+ "Abstract": "Corosolic acid (CA), a natural triterpenoid, exhibits various biological activities and is often called as plant-derived insulin due to its significant hypoglycemic effects, making it especially beneficial for individuals with diabetes or high blood glucose levels. However, CA has notable in vitro toxicity, low water solubility, and poor pharmacokinetic properties. To address these limitations, a series of CA derivatives were synthesized, resulting in the identification of derivative H26, which demonstrates a significantly enhanced hypoglycemic effect, reduced toxicity, and improved pharmacokinetic characteristics compared to CA. To identify the target protein of CA and investigate its therapeutic potential, a chemical probe derived from natural products, called CA-biotin, was designed and synthesized. By employing an avidin-biotin affinity binding system, we distinguished the differential protein bands between CA-biotin and biotin. This quantitative proteomic analysis revealed, for the first time, that the biotin-containing enzyme methylcrotonoyl-CoA carboxylase 1 (MCCC1) directly binds to CA. The interaction between H26 and MCCC1 was examined in vitro. The research on the mechanisms by which CA and H26 address Type 2 diabetes mellitus (T2DM) focused on the insulin resistance signaling pathway, specifically targeting MCCC1. The results indicated that H26 shows significant promise as a potential hypoglycemic agent, while MCCC1 may serve as a valuable target for addressing insulin resistance. This presents a promising opportunity for developing new medications aimed at improving the health of patients with type 2 diabetes mellitus (T2DM) or hyperglycemia.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Insulin Resistance",
+ "Animals",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Mice",
+ "Triterpenes",
+ "Male",
+ "Diabetes Mellitus, Experimental",
+ "Molecular Structure",
+ "Structure-Activity Relationship",
+ "Humans",
+ "Dose-Response Relationship, Drug",
+ "Mice, Inbred C57BL"
+ ]
+ },
+ {
+ "PMID": "39731761",
+ "Title": "Terapevticheskii arkhiv",
+ "ArticleTitle": "[Coagulase-negative staphylococci as a significant fact of generalization of infection in persons with a burdened comorbid background].",
+ "Abstract": "Since the era of the widespread introduction of antibiotics into the human sphere of activity, the problem of antimicrobial resistance has become an urgent and very important topic around the world. Recently, coagulasonegative staphylococci (CoNS), which are representatives of opportunistic microorganisms of the microbiome of the skin and mucous membranes of healthy people, have made a certain contribution to its progression. For a long time, they did not pose a threat to patients, but in recent decades among microorganisms they have been seeded in more than two-thirds of patients with postoperative mediastinitis, catheter-associated infections, as well as from wounds of the neck vessels and the inguinal region separated by pacemaker beds. This paper discloses, using clinical examples, the significance of CoNS in the formation of systemic inflammatory response syndrome in patients with a burdened comorbid background (type II diabetes mellitus, grade 3 arterial hypertension). During the examination of patients, it was shown that skin defects are foci of persistent bacteremia of representatives of the CoNS group, which can cause the development of a systemic inflammatory infectious response with the formation of resistant strains of the opportunistic flora of the microbiome of the skin and mucous membranes. It has been shown that to determine the tactics of antibacterial therapy, a bacteriological study of all detected foci of infection in patients, screening of pathogens and their sensitivity to antibiotics, and especially in persons at risk, is necessary. This will increase the effectiveness of antibacterial therapy and reduce the possibility of forming resistant strains of pathogens.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Anti-Bacterial Agents",
+ "Coagulase",
+ "Comorbidity",
+ "Diabetes Mellitus, Type 2",
+ "Staphylococcal Infections",
+ "Staphylococcus",
+ "Systemic Inflammatory Response Syndrome"
+ ]
+ },
+ {
+ "PMID": "39730990",
+ "Title": "BMC primary care",
+ "ArticleTitle": "The impact of the covid-19 pandemic on perceived diabetes care and regulation, with a focus on ethnic minorities: a mixed-methods study.",
+ "Abstract": "In the context of proactive care, remote healthcare and self-regulation have a crucial role for people with T2DM. It is important to identify barriers and facilitators for maintaining good glycaemic control among vulnerable groups, such as ethnic minority groups.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Aged",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "COVID-19",
+ "Diabetes Mellitus, Type 2",
+ "Ethnic and Racial Minorities",
+ "Primary Health Care",
+ "Prospective Studies",
+ "Telemedicine"
+ ]
+ },
+ {
+ "PMID": "39730877",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease.",
+ "Abstract": "This study evaluated the ability of the triglyceride (TG) to high-density lipoprotein cholesterol (TG/HDL-C) ratio to identify individuals at risk of type 2 diabetes mellitus (T2DM) in the non-alcoholic fatty liver disease (NAFLD) population. We retrospectively studied 4,769 patients with NAFLD from the Affiliated Hospital of Hangzhou Normal University (2020-2023). Binary logistic regression models were used to evaluate the association between the TG/HDL-C ratio and lipid parameters with T2DM. TG/HDL-C ratio was positively associated with T2DM in patients with NAFLD, with an odds ratio (OR) of 2.72 (95% confidence interval, 2.23-3.31, p\u2009<\u20090.001) for T2DM in the highest TG/HDL-C ratio quartile compared with the lowest one after adjusting for known confounders. The OR for the TG/HDL-C ratio had a stronger predictive value than those of TG, total cholesterol, HDL-C, and low-density lipoprotein cholesterol, indicating that the TG/HDL-C ratio could be a better discriminator of T2DM. The TG/HDL-C ratio better identifies potential risks of T2DM in individuals with NAFLD than individual lipid parameters. Therefore, clinicians should pay attention to individuals with high TG and low HDL-C levels during T2DM risk assessment in NAFLD cohorts.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Non-alcoholic Fatty Liver Disease",
+ "Triglycerides",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Cholesterol, HDL",
+ "Retrospective Studies",
+ "Adult",
+ "Risk Factors",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39730670",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients.",
+ "Abstract": "The correlation between thyroid hormone (TH) sensitivity and microvascular complications of type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to explore the association between TH sensitivity and the risk of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DNP) in euthyroid T2DM patients. This study included a total of 946 hospitalized T2DM patients and calculated their sensitivity to the TH index, and each patient completed screenings for DKD, DR, and DNP. Multivariate logistic regression, generalized additive modeling, and subgroup analysis were used to assess the association between TH index sensitivity and the risks of DKD, DR, and DNP. After adjusting for confounding factors, a significant linear correlation was observed between the sensitivity of the thyroid feedback quartile index 3 (TFQI3) and DKD risk. However, the sensitivities of thyroid-stimulating hormone index (TSHI), thyrotropin thyroxine resistance index (TT4RI) and partial thyroid feedback quartile index (PTFQI) exhibited nonlinear correlations with the risk of developing DKD. The effect sizes to the left of the inflection point for TSHI, TT4RI and PTFQI were (odd ratio [OR]\u2009=\u20090.53, 95% confidence interval [CI]: 0.288-0.977), (OR\u2009=\u20090.863, 95%Cl: 0.751-0.992) and (OR\u2009=\u20090.007, 95%Cl: 0-0.724), respectively. However, there was no significant correlation between TH index sensitivity and DR/DNP risk. This study provides valuable insights into the relationship between TH sensitivity and the risks of DKD, DR, and DNP, with substantial clinical implications for individual prediction among T2DM patients.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Thyroid Hormones",
+ "Aged",
+ "Diabetic Nephropathies",
+ "Diabetic Retinopathy",
+ "Diabetic Neuropathies",
+ "Thyrotropin",
+ "Thyroid Gland",
+ "Risk Factors",
+ "Thyroxine"
+ ]
+ },
+ {
+ "PMID": "39730430",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) is associated with cellular abnormalities, tissue and organ dysfunctions, and periodontitis. This investigation examined the relationship between the oral microbiome and salivary biomarkers in T2DM patients with or without periodontitis. This cohort (35-80\u00a0years) included systemically healthy non-periodontitis (NP; n\u2009=\u200931), T2DM without periodontitis (DWoP; n\u2009=\u200932) and T2DM with periodontitis (DWP; n\u2009=\u200929). The oral microbiome [Operational Taxonomic Units (OTUs)] (16\u00a0s rRNA sequencing) and targeted host salivary biomarkers (immunoassays) were assessed. We identified 47 OTUs that were significantly different in abundance between NP samples and any disease subset or between disease subgroups. The most unique microbiome patterns were observed in the DWP group. Differences in genera/species abundance were also observed when T2DM patients were stratified by extent of periodontal inflammation and disease (i.e., generalized versus localized gingivitis/periodontitis). Salivary biomarkers showed significant elevations in MMP-8, MMP-9, resistin, IL-1\u03b2, IL-6, IFN\u03b1, and BAFF (THFSR13b) comparing generalized to localized periodontitis. Salivary analytes showed significant positive correlations with specific microbiome members, predominantly in DWP patients. Odds ratio analyses reinforced that a panel of biologic markers (IL-6, MMP-8) and bacteria (e.g., Bacteroidetes, Fusobacteria, Spirochaetes) discriminated the severity and extent of periodontal disease in this diabetic population.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Middle Aged",
+ "Periodontitis",
+ "Male",
+ "Female",
+ "Aged",
+ "Saliva",
+ "Biomarkers",
+ "Gingivitis",
+ "Adult",
+ "Microbiota",
+ "Aged, 80 and over",
+ "RNA, Ribosomal, 16S"
+ ]
+ },
+ {
+ "PMID": "39730335",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Discontinuation rates, clinical effects and provocation factors of SGLT-2 inhibitor in the real world.",
+ "Abstract": "Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are the only medications that improve clinical outcomes regardless of baseline left ventricular ejection fraction. Despite the recognized effectiveness of SGLT-2 inhibitors, there remains a paucity of research on the discontinuation of these medications. The objective of this study is to analyze the rate of discontinuation of SGLT-2 inhibitors, to evaluate the impact of discontinuation on the clinical outcome, and to identify the factors associated with discontinuation. From 2015 to 2021, 775 heart failure patients prescribed an SGLT-2 inhibitor were retrospectively collated at Samsung Medical Center, Seoul, Republic of Korea. The SGLT-2 inhibitor discontinuation rate and the effect of SGLT-2 inhibitor discontinuation on clinical outcome were analyzed using the Kaplan-Meier survival curve. Factors related to discontinuation were analyzed through Cox regression and competing risk survival analysis. The discontinuation rate of SGLT-2 inhibitors was 7.5% at 1\u00a0year and 20% at 5\u00a0years. General weakness, over-diuresis and volume depletion, renal dysfunction progression, and urinary tract infections are the major reasons for discontinuing SGLT-2 inhibitors in general medical practice. The group that stopped using SGLT-2 inhibitors had a higher rate of heart failure hospitalization than the control group (adjusted HR 2.600, 95% CI [1.233-5.481], P\u2009=\u20090.012). In multivariable Cox regression analysis, the factors associated with total SGLT-2 inhibitor discontinuation were women (HR 2.478, 95% CI [1.553-3.953], P\u2009<\u20090.001) and lower estimated glomerular filtration rate (eGFR) (HR 0.884 per 10\u00a0ml/min/1.73\u00a0m",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Female",
+ "Male",
+ "Heart Failure",
+ "Middle Aged",
+ "Aged",
+ "Retrospective Studies",
+ "Diabetes Mellitus, Type 2",
+ "Republic of Korea"
+ ]
+ },
+ {
+ "PMID": "39730078",
+ "Title": "Contemporary clinical trials",
+ "ArticleTitle": "The sleep for health study: A randomized clinical trial of the impact of insomnia treatment on glycemia in people with prediabetes.",
+ "Abstract": "This trial is testing whether a program to improve sleep will positively impact glycemia among those with prediabetes. Registration with clinicaltrials.gov on October 3, 2023: NCT06067139.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sleep Initiation and Maintenance Disorders",
+ "Prediabetic State",
+ "Glycated Hemoglobin",
+ "Cognitive Behavioral Therapy",
+ "Blood Glucose",
+ "Male",
+ "Female",
+ "Insulin Resistance",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Blood Glucose Self-Monitoring",
+ "Adult",
+ "Patient Education as Topic",
+ "Aged",
+ "Sleep"
+ ]
+ },
+ {
+ "PMID": "39729922",
+ "Title": "International immunopharmacology",
+ "ArticleTitle": "Eldecalcitol alleviates diabetic periodontitis by regulating macrophage efferocytosis and polarization via SOCE machinery.",
+ "Abstract": "Diabetes exacerbates the occurrence and severity of periodontitis, the pathogenesis of diabetic periodontitis (DPD) is influenced by the delayed resolution of inflammation. Eldecalcitol (ED-71) has shown promise in preventing bone loss in DPD. We herein aimed to investigate the role of ED-71 in the inflammatory regression phase of DPD and elucidate the underlying mechanisms. Type-2 diabetes was induced by streptozotocin injection in Wistar rats, and to explore the in vivo effect of ED-71 on macrophage efferocytosis, periodontitis was induced by ligation combined with lipopolysaccharide. Alveolar bone destruction was assessed using micro-computed tomography, hematoxylin-eosin, immunohistochemistry, and tartrate-resistant acid phosphatase staining. Immunofluorescence staining and flow cytometry detected neutrophils, apoptotic cells, and macrophage polarization in periodontal tissue. Additionally, flow cytometry, real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay were used to examine macrophage efferocytosis and changes in store-operated calcium entry (SOCE). We found that rats with diabetes exhibited more severe alveolar bone destruction and increased neutrophil aggregates in periodontal tissue. Following the ED-71 administration, alveolar bone loss significantly decreased, and the immune microenvironment of periodontal tissue tended to suppress inflammation. Macrophages stimulated with high glucose experienced disruption of SOCE machinery, leading to the inhibition of efferocytosis in vitro. ED-71 demonstrated the ability to restore macrophage efferocytosis by correcting SOCE, and preventing sustained inflammatory damage to periodontal tissue. In conclusion, diabetes impairs macrophage efferocytosis and M2 polarization in periodontitis rats, resulting in the delayed resolution of inflammation. ED-71 could attenuate alveolar bone loss by mitigating macrophage via SOCE machinery in DPD.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Periodontitis",
+ "Male",
+ "Rats, Wistar",
+ "Macrophages",
+ "Diabetes Mellitus, Experimental",
+ "Rats",
+ "Alveolar Bone Loss",
+ "Vitamin D",
+ "Phagocytosis",
+ "Diabetes Mellitus, Type 2",
+ "Calcium",
+ "Efferocytosis"
+ ]
+ },
+ {
+ "PMID": "39729784",
+ "Title": "Cancer epidemiology",
+ "ArticleTitle": "The impact of type 2 diabetes on melanoma stage (TNM) at the time of diagnosis and its association with sex: A Danish nationwide study.",
+ "Abstract": "Individuals with T2D were more likely to be diagnosed with advanced stages of local, regional, and distant melanoma. This highlights the need for greater melanoma awareness and further research into treatment responses in individuals with T2D.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Melanoma",
+ "Male",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Denmark",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Aged",
+ "Neoplasm Staging",
+ "Adult",
+ "Sex Factors",
+ "Skin Neoplasms",
+ "Registries",
+ "Lymphatic Metastasis",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39729310",
+ "Title": "Genetic testing and molecular biomarkers",
+ "ArticleTitle": "Evaluation of Soluble Tumor Necrosis Factor-Like Weak Inducer of Apoptosis, Omentin, and Tumor Necrosis Factor-\u03b1 in Subjects with Periodontitis and Type 2 Diabetes Mellitus.",
+ "Abstract": {
+ "b": [
+ {
+ "i": "Purpose:"
+ },
+ {
+ "i": "Materials and Methods:"
+ },
+ {
+ "i": "Results:"
+ },
+ {
+ "i": "Conclusion:"
+ }
+ ]
+ },
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Lectins",
+ "Male",
+ "Female",
+ "GPI-Linked Proteins",
+ "Middle Aged",
+ "Periodontitis",
+ "Cytokines",
+ "Tumor Necrosis Factor-alpha",
+ "Adult",
+ "Biomarkers",
+ "Cytokine TWEAK",
+ "Glycated Hemoglobin"
+ ]
+ },
+ {
+ "PMID": "39729235",
+ "Title": "Journal of molecular histology",
+ "ArticleTitle": "Bolanthus turcicus: a promising antidiabetic with in-vitro antioxidant, enzyme inhibitory and antiadipogenic activities.",
+ "Abstract": "It is crucial to investigate new anti-diabetic agents and therapeutic approaches targeting molecules in potential signaling pathways for the treatment of Type 2 diabetes mellitus (T2DM). The objective of the study was to investigate the total phenolic content, antioxidant capacity, \u03b1-glucosidase, and \u03b1-amylase inhibitory activities of Bolanthus turcicus (B. turcicus), as well as their cytotoxic, anti-adipogenic, anti-diabetic, apoptotic, and anti-migration potential on adipocytes. B. turcicus samples were extracted with methanol (MeOH), ethyl acetate (EA) and aqueous (Aq) solvents. The MeOH extract had the highest phenolic content (81.14\u00a0mg GAE/g), followed by EA (74.93\u00a0mg GAE/g) and Aq (51.09\u00a0mg GAE/g). All extracts exhibited dose-dependent increases in \u03b1-glycosidase and \u03b1-amylase inhibitory activity. B. turcicus extracts showed cytotoxic effect on adipocytes with IC",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Antioxidants",
+ "Plant Extracts",
+ "Animals",
+ "Hypoglycemic Agents",
+ "Adipogenesis",
+ "Mice",
+ "Adipocytes",
+ "Apoptosis",
+ "Asteraceae",
+ "3T3-L1 Cells",
+ "alpha-Amylases",
+ "Cell Movement",
+ "Phenols",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39728692",
+ "Title": "Investigative ophthalmology & visual science",
+ "ArticleTitle": "Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy.",
+ "Abstract": "Retinal DHA is reduced in diabetic humans and mice, which is associated with a thinning of retina and functional defects in diabetic mice. Enriching retinal DHA through diet may be beneficial in the prevention and treatment of diabetic retinopathy.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Docosahexaenoic Acids",
+ "Animals",
+ "Diabetic Retinopathy",
+ "Mice",
+ "Humans",
+ "Electroretinography",
+ "Retina",
+ "Tomography, Optical Coherence",
+ "Male",
+ "Middle Aged",
+ "Mice, Inbred C57BL",
+ "Female",
+ "Diabetes Mellitus, Experimental",
+ "Gas Chromatography-Mass Spectrometry",
+ "Real-Time Polymerase Chain Reaction",
+ "Diabetes Mellitus, Type 2",
+ "Aged",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39726656",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Associations of adolescent obesity with hypertension, diabetes mellitus and polycystic ovaries in Arabs and Jews in Israel-a nationwide study.",
+ "Abstract": "The finding of a strong association of obesity severity with major cardiometabolic consequences in adolescence, as well as the unique ethnic features of these associations, can help focus national health initiatives on vulnerable adolescent groups.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Israel",
+ "Female",
+ "Adolescent",
+ "Arabs",
+ "Cross-Sectional Studies",
+ "Jews",
+ "Polycystic Ovary Syndrome",
+ "Hypertension",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2",
+ "Pediatric Obesity",
+ "Prevalence",
+ "Male",
+ "Comorbidity"
+ ]
+ },
+ {
+ "PMID": "39725431",
+ "Title": "BMJ open",
+ "ArticleTitle": "Pre-diabetes virtual health management community (VHMC) intervention and group interaction management model in China: a randomised clinical trial protocol.",
+ "Abstract": "ChiCTR2400081268. Study start: 1 July 2024, completion: 1 December 2026.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Prediabetic State",
+ "China",
+ "Diabetes Mellitus, Type 2",
+ "Randomized Controlled Trials as Topic",
+ "Prospective Studies",
+ "Single-Blind Method",
+ "Telemedicine",
+ "Multicenter Studies as Topic",
+ "Cost-Benefit Analysis",
+ "Male",
+ "Group Dynamics"
+ ]
+ },
+ {
+ "PMID": "39725366",
+ "Title": "Journal of ethnopharmacology",
+ "ArticleTitle": "Study on the mechanism on Yi-guan-jian decoction alleviating cognitive dysfunction in type 2 diabetes mellitus.",
+ "Abstract": "YGJ can alleviate glucose homeostasis, insulin sensitivity, lipid metabolism, neuroinflammation, cognitive function, as well as remodel intestinal flora and BA composition in CDT2DM rats, which is a potential complementary and alternative therapy for the prevention and treatment of CDT2DM. These effects may be associated that YGJ regulates the structure of intestinal flora and BA metabolism, and inhibits intestinal BA receptors FXR, PXR, TGR5, and VDR.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Diabetes Mellitus, Type 2",
+ "Drugs, Chinese Herbal",
+ "Male",
+ "Cognitive Dysfunction",
+ "Rats",
+ "Gastrointestinal Microbiome",
+ "Diabetes Mellitus, Experimental",
+ "Rats, Sprague-Dawley",
+ "Bile Acids and Salts",
+ "Hypoglycemic Agents",
+ "Insulin Resistance",
+ "Hippocampus",
+ "Maze Learning"
+ ]
+ },
+ {
+ "PMID": "39724976",
+ "Title": "Preventive medicine",
+ "ArticleTitle": "Adherence to recommended blood-based screening tests for cancer and chronic diseases: A systematic literature review.",
+ "Abstract": "Real-world adherence to recommended blood-based screening is suboptimal. Future research is needed to determine whether these findings are generalizable to blood-based CRC screening and to assess how such a strategy could impact clinical, economic, and health equity outcomes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Early Detection of Cancer",
+ "Colorectal Neoplasms",
+ "Mass Screening",
+ "Prostate-Specific Antigen",
+ "Chronic Disease",
+ "Male",
+ "Guideline Adherence",
+ "Prostatic Neoplasms",
+ "Diabetes Mellitus, Type 2",
+ "HIV Infections",
+ "Dyslipidemias"
+ ]
+ },
+ {
+ "PMID": "39723533",
+ "Title": "Annals of medicine",
+ "ArticleTitle": "Exploring the effect and mechanism of action of Jinlida granules (JLD) in\u00a0the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.",
+ "Abstract": "The findings suggested that JLD has the potential to improve TDACI through multiple components, multiple targets and multiple pathways. JLD may be a promising treatment for diabetic cognitive impairment.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Cognitive Dysfunction",
+ "Mice",
+ "Network Pharmacology",
+ "Molecular Docking Simulation",
+ "Diabetes Mellitus, Type 2",
+ "Drugs, Chinese Herbal",
+ "Male",
+ "Diabetes Mellitus, Experimental",
+ "Protein Interaction Maps",
+ "Hippocampus",
+ "Signal Transduction",
+ "Disease Models, Animal",
+ "Morris Water Maze Test"
+ ]
+ },
+ {
+ "PMID": "39722814",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Elevated circulating homocysteine concentrations delayed nerve conduction velocity and increase the risk of diabetic kidney disease in patients with type 2 diabetes.",
+ "Abstract": "The clinical assessment of homocysteine in diabetic patients holds significant importance in the prevention of microvascular complications. Lowering HCY levels may offer a promising therapeutic approach for managing microvascular disease in diabetes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Homocysteine",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Neural Conduction",
+ "Diabetic Nephropathies",
+ "Diabetic Neuropathies",
+ "Aged",
+ "Risk Factors",
+ "China"
+ ]
+ },
+ {
+ "PMID": "39722811",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Unveiling risk factors for post-COVID-19 syndrome development in people with type 2 diabetes.",
+ "Abstract": "Patients who were newly diagnosed with T2D, had HbA1c above 9.2%, had previous cardiovascular or cerebrovascular events, and had severe COVID-19 associated with mechanical lung ventilation were at high risk for PCS.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "COVID-19",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Risk Factors",
+ "Post-Acute COVID-19 Syndrome",
+ "Aged",
+ "Adult",
+ "Ukraine",
+ "SARS-CoV-2"
+ ]
+ },
+ {
+ "PMID": "39721796",
+ "Title": "Obesity (Silver Spring, Md.)",
+ "ArticleTitle": "Racial disparities in gestational weight gain and adverse pregnancy outcomes among Black and White pregnant people with obesity.",
+ "Abstract": "Black individuals\u00a0with obesity started pregnancy with higher weight and more preexisting conditions but had lower GWG compared to White individuals. Exacerbated disparities in preexisting conditions demonstrate higher health risks for Black individuals during pregnancy.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Pregnancy",
+ "Gestational Weight Gain",
+ "White People",
+ "Adult",
+ "Retrospective Studies",
+ "Pregnancy Outcome",
+ "Obesity",
+ "COVID-19",
+ "Pregnancy Complications",
+ "Black or African American",
+ "Health Status Disparities",
+ "Louisiana",
+ "Diabetes, Gestational",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39720906",
+ "Title": "European journal of endocrinology",
+ "ArticleTitle": "Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model.",
+ "Abstract": "Baseline HbA1c and 2-h OGTT glucose predict incident type 2 diabetes at 2 years in high-risk men, with risk modified independently by testosterone treatment. Men with HbA1c \u2265 5.6% (38\u2005mmol/mol) benefit most from testosterone treatment, beyond a lifestyle program.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Testosterone",
+ "Middle Aged",
+ "Aged",
+ "Australia",
+ "Risk Factors",
+ "Glucose Tolerance Test",
+ "Glycated Hemoglobin",
+ "Prognosis",
+ "Blood Glucose",
+ "Glucose Intolerance",
+ "Life Style",
+ "Risk Assessment"
+ ]
+ },
+ {
+ "PMID": "39720308",
+ "Title": "Journal of diabetes research",
+ "ArticleTitle": "Young-Onset Diabetes in Sri Lanka: Experience From the Developing World.",
+ "Abstract": {
+ "b": "Conclusion:",
+ "i": "p"
+ },
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sri Lanka",
+ "Female",
+ "Male",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2",
+ "Age of Onset",
+ "Retrospective Studies",
+ "Prevalence",
+ "Developing Countries",
+ "Child",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Diabetic Ketoacidosis"
+ ]
+ },
+ {
+ "PMID": "39720253",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Sclerostin as a new target of diabetes-induced osteoporosis.",
+ "Abstract": "Sclerostin, a protein synthesized by bone cells, is a product of the ",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Osteoporosis",
+ "Adaptor Proteins, Signal Transducing",
+ "Diabetes Mellitus, Type 1",
+ "Diabetes Mellitus, Type 2",
+ "Animals",
+ "Genetic Markers",
+ "Wnt Signaling Pathway",
+ "Bone Morphogenetic Proteins"
+ ]
+ },
+ {
+ "PMID": "39720249",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Traditional versus intensive blood glucose control: long-term target range duration and cardiovascular disease risk and all-cause mortality - a real-world cohort study.",
+ "Abstract": "In patients with type 2 diabetes, achieving near-normal blood glucose levels appears to significantly reduce the risk of diabetes-related cardiovascular outcomes.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cardiovascular Diseases",
+ "Male",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Middle Aged",
+ "Blood Glucose",
+ "Glycemic Control",
+ "Cohort Studies",
+ "Aged",
+ "Follow-Up Studies",
+ "Risk Factors",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Cause of Death",
+ "China"
+ ]
+ },
+ {
+ "PMID": "39720248",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Associations between non-insulin-based insulin resistance indices and diabetic nephropathy in patients with diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.",
+ "Abstract": "Non-insulin-based insulin resistance indices are significantly associated with the risk of DN. The TyG index is a superior tool for assessing the risk of DN. These indices can assist in identifying patients at risk of DN, thereby enabling the implementation of more effective preventive and therapeutic strategies.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Insulin Resistance",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Diabetic Nephropathies",
+ "Middle Aged",
+ "Nutrition Surveys",
+ "United States",
+ "Adult",
+ "Aged",
+ "Risk Factors",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 2",
+ "Body Mass Index"
+ ]
+ },
+ {
+ "PMID": "39720247",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis.",
+ "Abstract": "Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient insulin secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, the prevalence of T2DM has shown a sharp rise due to profound changes in socio-economic structure, the persistent influence of environmental factors, and the complex role of genetic background. It is worth noting that most T2DM patients show significant IR, which further exacerbates the difficulty of disease progression and prevention. In the process of extensively exploring the pathogenesis of T2DM, the dynamic equilibrium of gut microbes and its diverse metabolic activities have increasingly emphasized its central role in the pathophysiological process of T2DM. Bile acids (BAs) metabolism, as a crucial link between gut microbes and the development of T2DM, not only precisely regulates lipid absorption and metabolism but also profoundly influences glucose homeostasis and energy balance through intricate signaling pathways, thus playing a pivotal role in IR progression in T2DM. This review aims to delve into the specific mechanism through which BAs contribute to the development of IR in T2DM, especially emphasizing how gut microbes mediate the metabolic transformation of BAs based on current traditional Chinese medicine research. Ultimately, it seeks to offer new insights into the prevention and treatment of T2DM. Diet, genetics, and the environment intricately sculpt the gut microbiota and BAs metabolism, influencing T2DM-IR. The research has illuminated the significant impact of single herbal medicine, TCM formulae, and external therapeutic methods such as electroacupuncture on the BAs pool through perturbations in gut microbiota structure. This interaction affects glucose and lipid metabolism as well as insulin sensitivity. Additionally, multiple pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR signaling pathways have been identified through which the BAs pool significantly alter blood glucose levels and improve IR. These findings offer novel approaches for enhancing IR and managing metabolic disorders among patients with T2DM.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Gastrointestinal Microbiome",
+ "Insulin Resistance",
+ "Bile Acids and Salts",
+ "Medicine, Chinese Traditional",
+ "Precision Medicine",
+ "Animals"
+ ]
+ },
+ {
+ "PMID": "39720175",
+ "Title": "Journal of medicine and life",
+ "ArticleTitle": "The impact of patient support and health education on diabetes management and glycemic control.",
+ "Abstract": "Diabetes mellitus is a chronic and complex medical condition that can lead to significant morbidity and mortality. Maintaining an adequate blood glucose level is important for patients with diabetes, and to improve glycemic control, patients need proper support and health education, which are essential components of comprehensive diabetes care. We used a rigorous approach based on the PRISMA and Cochrane Handbook principles, specifically focusing on randomized controlled trials (RCTs) published in English from 2005 onwards. The statistical analysis was conducted using the RevMan software. Pooled risk ratios were calculated for dichotomous data, whereas mean differences were calculated for continuous data. Heterogeneity and publication bias were also evaluated. From an initial pool of 544 records, 368 studies were examined after eliminating duplicates. Ultimately, 24 studies were deemed suitable based on the inclusion criteria. These studies involved 2437 participants in the intervention group and 2305 people in the control group. The quality assessment indicated that 41.7% of the studies were categorized as low risk, 16.7% as high risk, and 41.7% had certain concerns regarding bias. The analyses revealed noteworthy decreases in HbA1c levels in the intervention group at several time points, particularly showing improvements after 3 months. Egger's regression indicated the presence of possible publication bias. The results emphasize the crucial impact of health education and mentorship interventions on enhancing glycemic control in individuals with type 2 diabetes. Interventions focused on empowering patients proved to be especially effective in enhancing diabetes management outcomes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glycemic Control",
+ "Diabetes Mellitus, Type 2",
+ "Health Education",
+ "Glycated Hemoglobin",
+ "Blood Glucose",
+ "Patient Education as Topic"
+ ]
+ },
+ {
+ "PMID": "39720174",
+ "Title": "Journal of medicine and life",
+ "ArticleTitle": "Impact of type 2 diabetes mellitus on the prevalence of apical periodontitis in endodontically treated and untreated teeth.",
+ "Abstract": "Apical periodontitis (AP) is a common dental condition that can be influenced by diabetes mellitus. This study aimed to investigate the impact of type 2 diabetes mellitus (T2DM) on the prevalence and severity of AP, considering the adequacy of endodontic treatments. A total of 180 patients selected based on specific dental criteria from a private clinic in Oradea, Romania, were included in this study. Clinical data were collected through medical records and panoramic radiographs. Statistical analyses were conducted using SPSS software, employing the Fisher test, Mann-Whitney test, and binary logistic regression to determine correlations between T2DM and AP in both endodontically treated and non-treated teeth. Additionally, we examined the relationship between diabetes and AP in teeth that received adequate root canal treatment (RCT), as well as the correlation of AP with the adequacy of endodontic treatment. Non-treated teeth were significantly more likely to have AP in patients with T2DM than in non-diabetic patients (OR = 5.3, ",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Periapical Periodontitis",
+ "Diabetes Mellitus, Type 2",
+ "Prevalence",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Root Canal Therapy",
+ "Adult",
+ "Romania",
+ "Tooth, Nonvital",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39719839",
+ "Title": "Shanghai kou qiang yi xue = Shanghai journal of stomatology",
+ "ArticleTitle": "[Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis].",
+ "Abstract": "TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis, and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "TNF-Related Apoptosis-Inducing Ligand",
+ "Diabetes Mellitus, Type 2",
+ "Periodontitis",
+ "Genetic Predisposition to Disease",
+ "Polymorphism, Single Nucleotide",
+ "Gene Frequency",
+ "Genotype",
+ "Blood Glucose",
+ "Polymorphism, Genetic",
+ "Glycated Hemoglobin"
+ ]
+ },
+ {
+ "PMID": "39719724",
+ "Title": "Clinical nutrition (Edinburgh, Scotland)",
+ "ArticleTitle": "Effects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial.",
+ "Abstract": "This study was registered on the website of www.chictr.org.cn, number ChiCTR2100052187.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Synbiotics",
+ "Double-Blind Method",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Probiotics",
+ "Blood Glucose",
+ "Gastrointestinal Microbiome",
+ "Glycated Hemoglobin",
+ "Bifidobacterium animalis",
+ "Insulin Resistance",
+ "Treatment Outcome",
+ "Insulin"
+ ]
+ },
+ {
+ "PMID": "39719658",
+ "Title": "European journal of medical research",
+ "ArticleTitle": "The association between sodium-glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: a propensity-matched study.",
+ "Abstract": "New use of SGLT2i during CA or PCI was not associated with an AKIN-defined CA-AKI, and it did not translate into new-onset dialysis or death during hospital stay. Chronic usage of SGLT2i did not affect creatinine. Further randomized clinical trials are warranted to confirm this finding.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Acute Kidney Injury",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Contrast Media",
+ "Aged",
+ "Coronary Angiography",
+ "Propensity Score",
+ "Percutaneous Coronary Intervention",
+ "Creatinine",
+ "China",
+ "Incidence",
+ "Retrospective Studies"
+ ]
+ },
+ {
+ "PMID": "39719583",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Evaluation and comparison of efficacy and safety of tirzepatide, liraglutide and SGLT2i in patients with type 2 diabetes mellitus: a network meta-analysis.",
+ "Abstract": "Out of the seven medications examined in this study, tirzepatide demonstrates the most effective antidiabetic and weight-reducing effects. Furthermore, the dosage of Liraglutide at 1.2 mg and above demonstrates a more pronounced hypoglycemic effect in comparison to SGLT2 inhibitors. SGLT2 inhibitors exhibit a distinct hypotensive effect and are suitable for diabetic individuals experiencing hypertension.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Liraglutide",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Network Meta-Analysis",
+ "Hypoglycemic Agents",
+ "Randomized Controlled Trials as Topic",
+ "Treatment Outcome",
+ "Glucosides",
+ "Glycated Hemoglobin",
+ "Blood Glucose",
+ "Glucagon-Like Peptide-2 Receptor",
+ "Gastric Inhibitory Polypeptide",
+ "Tirzepatide"
+ ]
+ },
+ {
+ "PMID": "39719404",
+ "Title": "Journal of the American Heart Association",
+ "ArticleTitle": "Atherothrombotic Outcomes After Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes: A Territory-Wide Retrospective Cohort Study.",
+ "Abstract": "SGLT2 inhibitors in patients with diabetes were independently associated with reduction in atherothrombotic major adverse cardiovascular events, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, and incident dialysis, compared with DPP-4 inhibitors.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Dipeptidyl-Peptidase IV Inhibitors",
+ "Male",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Middle Aged",
+ "Sodium-Glucose Transporter 2 Inhibitors",
+ "Retrospective Studies",
+ "Aged",
+ "Hong Kong",
+ "Treatment Outcome",
+ "Risk Factors",
+ "Risk Assessment",
+ "Myocardial Infarction",
+ "Thrombosis",
+ "Time Factors",
+ "Stroke"
+ ]
+ },
+ {
+ "PMID": "39719391",
+ "Title": "BMJ open diabetes research & care",
+ "ArticleTitle": "Differential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes: potential for more personalized interventions.",
+ "Abstract": "Carbohydrate intake, sleep and physical activity at specific points in time have both fixed as well as individualized effects on glucose concentrations 2 hours later in individuals with type 2 diabetes. Interindividual differences in glycemic response to lifestyle components call for personalized advice in the management of type 2 diabetes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Blood Glucose",
+ "Life Style",
+ "Exercise",
+ "Aged",
+ "Sleep",
+ "Hypoglycemic Agents",
+ "Follow-Up Studies",
+ "Precision Medicine",
+ "Adult",
+ "Biomarkers",
+ "Prognosis"
+ ]
+ },
+ {
+ "PMID": "39719314",
+ "Title": "BMJ open diabetes research & care",
+ "ArticleTitle": "Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia.",
+ "Abstract": "Insulin sensitivity, secretion, and clearance differ significantly in normoglycemic African American versus European American offspring of parents with type 2 diabetes and are associated with the risk of incident dysglycemia.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Biomarkers",
+ "Black or African American",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 2",
+ "Follow-Up Studies",
+ "Glucose Clamp Technique",
+ "Glucose Tolerance Test",
+ "Incidence",
+ "Insulin",
+ "Insulin Resistance",
+ "Insulin Secretion",
+ "Parents",
+ "Prediabetic State",
+ "Prognosis",
+ "Prospective Studies",
+ "White"
+ ]
+ },
+ {
+ "PMID": "39719282",
+ "Title": "BMJ open",
+ "ArticleTitle": "Theory-based behaviour modification of Asian adults with type-2 diabetes mellitus after participating in a novel telemonitoring system: a qualitative research study.",
+ "Abstract": "NCT04306770.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Qualitative Research",
+ "Singapore",
+ "Telemedicine",
+ "Adult",
+ "Self Efficacy",
+ "Aged",
+ "Health Behavior",
+ "Asian People",
+ "Blood Glucose",
+ "Blood Glucose Self-Monitoring",
+ "Blood Pressure"
+ ]
+ },
+ {
+ "PMID": "39719183",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD.",
+ "Abstract": "NAFLD-non-MASLD patients with 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L are still at high risk of poor clinical outcomes. These findings support including 1-h PG\u00a0\u2265\u00a08.6\u00a0mmol/L as a component of the metabolic dysfunction definition.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Non-alcoholic Fatty Liver Disease",
+ "Blood Glucose",
+ "Retrospective Studies",
+ "Glucose Tolerance Test",
+ "Adult",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Risk Factors",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39719182",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study.",
+ "Abstract": "YKL-40 is a prognostic biomarker for most CVEs, and even more so for all-cause mortality, primarily driven by cancer-related causes.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Chitinase-3-Like Protein 1",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Denmark",
+ "Cardiovascular Diseases",
+ "Biomarkers",
+ "Cohort Studies",
+ "C-Reactive Protein"
+ ]
+ },
+ {
+ "PMID": "39719170",
+ "Title": "Metabolism: clinical and experimental",
+ "ArticleTitle": "Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis.",
+ "Abstract": "Potent GLP-1 RAs, such as tirzepatide and semaglutide, demonstrate greater overall weight loss but are associated with a significant reduction in lean mass.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glucagon-Like Peptide-1 Receptor",
+ "Body Composition",
+ "Network Meta-Analysis as Topic",
+ "Obesity",
+ "Hypoglycemic Agents",
+ "Randomized Controlled Trials as Topic",
+ "Receptors, Gastrointestinal Hormone",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ]
+ },
+ {
+ "PMID": "39719165",
+ "Title": "Life sciences",
+ "ArticleTitle": "Semaglutide alleviates the pancreatic \u03b2 cell function via the METTL14 signaling and modulating gut microbiota in type 2 diabetes mellitus mice.",
+ "Abstract": "Semaglutide positively influences by regulating m6A modifications to alleviate pancreatic beta cell dysfunction and modulate the gut microbiome.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Insulin-Secreting Cells",
+ "Male",
+ "Glucagon-Like Peptides",
+ "Mice",
+ "Gastrointestinal Microbiome",
+ "Mice, Inbred C57BL",
+ "Diabetes Mellitus, Type 2",
+ "Signal Transduction",
+ "Diabetes Mellitus, Experimental",
+ "Methyltransferases",
+ "Diet, High-Fat",
+ "Hypoglycemic Agents"
+ ]
+ },
+ {
+ "PMID": "39718468",
+ "Title": "Endocrinology, diabetes & metabolism",
+ "ArticleTitle": "Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial.",
+ "Abstract": "Reduction in liver fat content effectively improves pancreatic islet function secretion, particularly postprandial c-peptide secretion, especially in the first hour after a meal. This improvement leads to a decrease in glycated haemoglobin levels and promotes better compliance with blood glucose control.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon-Like Peptides",
+ "Immunoglobulin Fc Fragments",
+ "Liver",
+ "Recombinant Fusion Proteins",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Non-alcoholic Fatty Liver Disease",
+ "Aged",
+ "Glycated Hemoglobin",
+ "Blood Glucose",
+ "Cohort Studies",
+ "Treatment Outcome"
+ ]
+ },
+ {
+ "PMID": "39718016",
+ "Title": "Adipocyte",
+ "ArticleTitle": "Correlation analysis of key genes and immune infiltration in visceral adipose tissue and subcutaneous adipose tissue of patients with type 2 diabetes in women.",
+ "Abstract": "Immune cell infiltration into adipose tissue (AT) is a key factor in type 2 diabetes (T2DM). However, research on the impact of fat distribution on immune cells and immune responses in women is still lacking. This study used enrichment, protein-protein interaction network, immune cell infiltration, and correlation analysis to compare the similarities and differences between the transcriptome data of visceral AT (VAT) and subcutprotein-proteinaneous AT (SAT) obtained from the omprehensive database of gene expression in women with non-T2DM and T2DM. DEGs with the same biological function in two types of ATs often exhibited different expression trends. SharedVAT-specific and SAT-specific hub genes were mainly associated with transcription factors, monocyte-macrophage markers, and chemokines, respectively. Immune cells affected by both AT types included monocytes, granulocytes, T and B lymphocytes, and NK cells. VAT affected more immune cells, mainly myeloid cells. Shared hub genes in VAT correlated positively with M1 macrophages, suggesting pro-inflammatory effects, while those in SAT correlated negatively with M1 macrophages and lymphocytes, suggesting anti-inflammatory effects. This study provides a theoretical basis for further understanding the correlation between AT and T2DM in women.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Intra-Abdominal Fat",
+ "Subcutaneous Fat",
+ "Transcriptome",
+ "Gene Expression Profiling",
+ "Macrophages",
+ "Protein Interaction Maps"
+ ]
+ },
+ {
+ "PMID": "39717954",
+ "Title": "Molecular medicine reports",
+ "ArticleTitle": "Insights into renal damage in hyperuricemia: Focus on renal protection (Review).",
+ "Abstract": "The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction\u2011associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage. A number of randomized controlled clinical trials have investigated the effectiveness of UA\u2011lowering therapies in preventing kidney disease progression. The present review provided fundamental insights into the pathogenesis, principles and therapeutic approaches for managing hyperuricemia in patients with aforementioned diseases and assesses the effect of uric acid\u2011lowering therapy on diabetic nephropathy, systemic lupus erythematosus, CKD, CVD and obesity progression.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hyperuricemia",
+ "Uric Acid",
+ "Renal Insufficiency, Chronic",
+ "Kidney",
+ "Animals",
+ "Obesity",
+ "Diabetes Mellitus, Type 2",
+ "Cardiovascular Diseases",
+ "Gout"
+ ]
+ },
+ {
+ "PMID": "39717105",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Risk factor screening and prediction modeling of gastrointestinal adverse reactions caused by GLP-1RAs.",
+ "Abstract": "The established nomogram model has an excellent predictive effect on GISEs induced by GLP-1RAs in patients with T2DM.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Diabetes Mellitus, Type 2",
+ "Risk Factors",
+ "Gastrointestinal Diseases",
+ "Nomograms",
+ "Aged",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Prognosis",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ]
+ },
+ {
+ "PMID": "39716666",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Association of Novel Clinical and Behavioural Markers with HbA1c Improvement: A Latent Class Analysis of 912 Patients with Type 2 Diabetes Mellitus.",
+ "Abstract": "Individuals with higher baseline HbA1c, education, motivation, and activity levels experienced the most significant HbA1c reductions in response to lifestyle interventions. A tailored approach to these modifiable characteristics may help patients achieve substantial 12-month HbA1c reductions.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Glycated Hemoglobin",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Latent Class Analysis",
+ "Prospective Studies",
+ "Aged",
+ "Exercise",
+ "Adult",
+ "Motivation",
+ "Singapore",
+ "Educational Status",
+ "Life Style",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39716481",
+ "Title": "Clinical science (London, England : 1979)",
+ "ArticleTitle": "Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge.",
+ "Abstract": "Chronic inflammatory diseases, e.g., obesity, cardiovascular disease and type-2 diabetes, progressively suppress the anti-inflammatory heat shock response (HSR) by impairing the synthesis of key components, perpetuating inflammation. Monitoring HSR progression offers predictive value for countering chronic inflammation. This study quantified HSR in high-fat diet (HFD) and normal chow (NC) mice by measuring 70 kDa heat shock protein (HSP70) expression after heat treatment of whole blood samples. To align with human translational relevance, animals were housed within their thermoneutral zone (TNZ). Whole blood was heat-challenged weekly at 42 \u00b0C for 1-2 hours over 22 weeks, and \u0394HSP70 was calculated as the difference between HSP70 expressions at 42 \u00b0C and 37 \u00b0C. Results correlated with fasting glycaemia, oral glucose tolerance test, intraperitoneal insulin tolerance test and 2-hour post-glucose load glycaemia. \u0394HSP70 levels >0.2250 indicated normal fasting glycaemia, while levels <0.2125 signalled insulin resistance and type-2 diabetes onset. A logistic model (five-parameter logistic) showed progressive HSR decline, with HFD mice exhibiting earlier \u0394HSP70 reduction (t1/2 = 3.14 weeks) compared with NC mice (t1/2 = 8.24 weeks), highlighting compromised anti-inflammatory capacity in both groups of mice maintained at TNZ. Remarkably, even NC mice surpassed insulin resistance thresholds by week 22, relevant as control diets confronted interventions. Observed HSR decline mirrors tissue-level suppression in obese and type-2 diabetic individuals, underscoring HSR failure as a hallmark of obesity-driven inflammation. This study introduces a practical whole-blood assay to evaluate HSR suppression, allowing assessment of glycaemic status during obesity onset before any clinical manifestation.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Insulin Resistance",
+ "Heat-Shock Response",
+ "Male",
+ "Diet, High-Fat",
+ "Mice, Inbred C57BL",
+ "HSP70 Heat-Shock Proteins",
+ "Disease Progression",
+ "Blood Glucose",
+ "Mice",
+ "Hot Temperature",
+ "Early Diagnosis",
+ "Diabetes Mellitus, Type 2",
+ "Obesity",
+ "Inflammation"
+ ]
+ },
+ {
+ "PMID": "39716335",
+ "Title": "Journal of neuroinflammation",
+ "ArticleTitle": "Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes.",
+ "Abstract": "Treg modulation in T2D offers a promising therapeutic approach to prevent early stages of DR. This strategy focuses on reducing neuroinflammation and mitigating the associated neuronal, glial, and vascular degenerative changes characteristic of DR.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Mice",
+ "T-Lymphocytes, Regulatory",
+ "Diabetes Mellitus, Type 2",
+ "Retinal Degeneration",
+ "Mice, Inbred C57BL",
+ "Male",
+ "Diabetic Retinopathy",
+ "Retina"
+ ]
+ },
+ {
+ "PMID": "39716328",
+ "Title": "Alzheimer's research & therapy",
+ "ArticleTitle": "Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials.",
+ "Abstract": "Compared with non-users, SGLT-2i, GLP-1RA, TZD and metformin were associated with the reduced risk of dementia in patients with T2D. SGLT-2i, and GLP-1RA may serve as the optimal choice to improve the cognitive prognosis in patients with T2D.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Dementia",
+ "Diabetes Mellitus, Type 2",
+ "Hypoglycemic Agents",
+ "Network Meta-Analysis",
+ "Observational Studies as Topic",
+ "Randomized Controlled Trials as Topic",
+ "Sodium-Glucose Transporter 2 Inhibitors"
+ ]
+ },
+ {
+ "PMID": "39716288",
+ "Title": "The international journal of behavioral nutrition and physical activity",
+ "ArticleTitle": "The efficacy of using continuous glucose monitoring as a behaviour change tool in populations with and without diabetes: a systematic review and meta-analysis of randomised controlled trials.",
+ "Abstract": "CRD42024514135.",
+ "Predictions": [
+ "Diabetes type 1",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Randomized Controlled Trials as Topic",
+ "Blood Glucose Self-Monitoring",
+ "Diabetes Mellitus, Type 2",
+ "Blood Glucose",
+ "Exercise",
+ "Health Behavior",
+ "Diabetes Mellitus, Type 1",
+ "Female",
+ "Adult",
+ "Glycated Hemoglobin",
+ "Pregnancy",
+ "Continuous Glucose Monitoring"
+ ]
+ },
+ {
+ "PMID": "39716258",
+ "Title": "Lipids in health and disease",
+ "ArticleTitle": "The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.",
+ "Abstract": "Overall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomarkers",
+ "Blood Glucose",
+ "Cardiovascular Diseases",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus, Type 2",
+ "Insulin Resistance",
+ "Metabolic Syndrome",
+ "Triglycerides"
+ ]
+ },
+ {
+ "PMID": "39716230",
+ "Title": "Journal of medical case reports",
+ "ArticleTitle": "Applying auricular magnetic therapy to decrease blood glucose levels and promote the healing of gangrene in diabetes patients: a case report.",
+ "Abstract": "Auricular static magnetic therapy has demonstrated efficacy as a beneficial treatment for diabetes. This therapeutic approach has been shown to reduce blood glucose levels, increase blood circulation, and promote gangrene healing. Its noninvasive nature, rapid onset of action, and cost-effectiveness are notable attributes. The novel contribution of this case report resides in its potential application as a complementary therapy for diabetes utilized in conjunction with conventional Western medical practices.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Gangrene",
+ "Diabetes Mellitus, Type 2",
+ "Blood Glucose",
+ "Acupuncture, Ear",
+ "Wound Healing",
+ "Treatment Outcome",
+ "Amputation, Surgical",
+ "Acupuncture Points",
+ "Magnetic Field Therapy"
+ ]
+ },
+ {
+ "PMID": "39716081",
+ "Title": "Molecular medicine (Cambridge, Mass.)",
+ "ArticleTitle": "Uncovering the molecular networks of ferroptosis in the pathogenesis of type 2 diabetes and its complications: a multi-omics investigation.",
+ "Abstract": "This study identified FRGs in relation to T2D and its complications, which may enhance the understanding of the pathogenic mechanisms of their development. Meanwhile, it offers cross-validation for imaging genomics and further indicates the direction for non-invasive diagnosis.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Ferroptosis",
+ "Gene Regulatory Networks",
+ "Genetic Predisposition to Disease",
+ "Genomics",
+ "Male",
+ "Diabetes Complications",
+ "Female",
+ "Gene Expression Profiling",
+ "Polymorphism, Single Nucleotide",
+ "Computational Biology",
+ "Genetic Association Studies",
+ "Multiomics"
+ ]
+ },
+ {
+ "PMID": "39716056",
+ "Title": "BMC genomics",
+ "ArticleTitle": "Evaluation of Bayesian Linear Regression derived gene set test methods.",
+ "Abstract": "Comparing our method with other approaches, such as the gold standard MAGMA (Multi-marker Analysis of Genomic Annotation) approach, our BLR gene set test showed superior performance. Combining performance of our method in simulated and real phenotypes, this suggests that our BLR-based approach could more accurately identify genes and biological pathways underlying complex diseases.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Bayes Theorem",
+ "Diabetes Mellitus, Type 2",
+ "Humans",
+ "Linear Models",
+ "Linkage Disequilibrium",
+ "Quantitative Trait Loci",
+ "Phenotype",
+ "Computer Simulation",
+ "Models, Genetic",
+ "Genome-Wide Association Study"
+ ]
+ },
+ {
+ "PMID": "39715944",
+ "Title": "Obesity surgery",
+ "ArticleTitle": "Diabetes Remission After\u00a0Bariatric\u00a0Surgery: A 10-Year Follow-Up Study.",
+ "Abstract": "MBS can induce a significant improvement and sustainable remission of T2DM. Early intervention, while patients still have a good glycemic control with a lower number of anti-diabetic drugs, is crucial to achieve long-lasting benefits and a potential \"surgical cure\" for T2DM.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Bariatric Surgery",
+ "Blood Glucose",
+ "Diabetes Mellitus, Type 2",
+ "Follow-Up Studies",
+ "Glycated Hemoglobin",
+ "Glycemic Control",
+ "Hypoglycemic Agents",
+ "Obesity, Morbid",
+ "Recurrence",
+ "Remission Induction",
+ "Retrospective Studies",
+ "Treatment Outcome",
+ "Weight Loss"
+ ]
+ },
+ {
+ "PMID": "39715341",
+ "Title": "Endocrinology",
+ "ArticleTitle": "GLP-1 and Its Analogs: Does Sex Matter?",
+ "Abstract": "While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeutics, glucagon-like peptide 1 (GLP-1) analogs (eg, semaglutide), shows promise at curbing both diseases. This review addresses the topic of sex differences in the endogenous and therapeutic actions of GLP-1 and its analogs. Work on sex differences in human studies and animal research is reviewed. Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted. Moreover, recent clinical evidence of sex differences in the therapeutic effects of GLP-1 analogs in obesity, diabetes, and cardiovascular disease are discussed. Lastly, we review evidence for the role of GLP-1 analogs in mood and reproductive function, with particular attention to sex differences. Overall, while we did not find evidence for many qualitative sex differences in the therapeutic effect of clinically approved GLP-1 analogs, a growing body of literature highlights quantitative sex differences in the response to GLP-1 and its analogs as well as an interaction of these therapeutics with estrogens. What also clearly emerges is the paucity of data in female animal models or women in very basic aspects of the science of GLP-1-gaps that should be urgently mended, given the growing popularity of these medications, especially in women.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glucagon-Like Peptide 1",
+ "Animals",
+ "Female",
+ "Male",
+ "Sex Characteristics",
+ "Obesity",
+ "Glucagon-Like Peptides",
+ "Hypoglycemic Agents",
+ "Sex Factors",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39715135",
+ "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
+ "ArticleTitle": "ABCC8 polymorphisms rs757110 and rs1801261 association with sulfonylurea therapy of Iraqi type 2 diabetics.",
+ "Abstract": "Conclusions: The rs757110 related to less insulin excretion in T2DM of Iraqi Middle Euphrates population who received glimepiride and glibenclamide for diabetes treatment.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Sulfonylurea Compounds",
+ "Iraq",
+ "Sulfonylurea Receptors",
+ "Case-Control Studies",
+ "Polymorphism, Single Nucleotide",
+ "Middle Aged",
+ "Hypoglycemic Agents",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39713052",
+ "Title": "Frontiers in endocrinology",
+ "ArticleTitle": "Research progress on the relationship between free fatty acid profile and type 2 diabetes complicated by coronary heart disease.",
+ "Abstract": "Patients with type 2 diabetes mellitus (T2DM) have a 2 to 3 times higher risk of cardiovascular disease compared to non-diabetic individuals, and cardiovascular disease has consistently been a leading cause of death among diabetic patients. Therefore, preventing cardiovascular disease in diabetic patients remains a significant challenge. In addition to classic indicators such as cholesterol and lipoproteins, previous studies have demonstrated that plasma level of free fatty acid (FFA) is closely related to the occurrence of atherosclerosis, particularly in T2DM patients. In recent years, with further research and advancements in testing technologies, the FFA profile has garnered widespread attention. The FFA profile includes many different types of FFAs, and changes in the plasma FFA profile and concentrations in T2DM patients may lead to the development of insulin resistance, causing damage to vascular endothelial cells and promoting the occurrence and progression of atherosclerosis. Furthermore, some FFAs have shown potential in predicting cardiovascular complications in T2DM and are associated with the severity of these complications. Here, we aim to review the changes in the FFA profile in T2DM and discuss the relationship between the FFA profile and the occurrence of vascular complications in T2DM.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Fatty Acids, Nonesterified",
+ "Coronary Disease",
+ "Insulin Resistance"
+ ]
+ },
+ {
+ "PMID": "39710901",
+ "Title": "International ophthalmology clinics",
+ "ArticleTitle": "Glucagon-like Peptide-1 Receptor Agonists in the Management of Diabetic Retinopathy.",
+ "Abstract": "Glucagon-like peptide-1 (GLP-1) receptor agonists are a family of drugs, most well known by the third-generation once-weekly subcutaneous semaglutide, that act on the incretin pathway of metabolic, hormonal signaling to modulate pancreatic insulin release, gastric emptying, energy intake, and subjective feelings of satiety. This class of drugs' efficacy and safety in the treatment of type 2 diabetes and obesity have been demonstrated across multiple large randomized controlled trials. These data have propelled GLP-1 receptor agonists to ubiquity in diabetic management and weight loss therapy, leading them to be frequently encountered in ophthalmic practice. The effect of GLP-1 receptor agonists like semaglutide on diabetic retinopathy (DR) is at this point unclear; some studies indicate a worsening of DR with the initiation of GLP-1 agonists, especially semaglutide. Overall, the macrovascular reduction of cardiovascular and stroke risks from GLP-1 receptor agonists should be prioritized over the potential microvascular progression of DR, as long as the patient is regularly followed by ophthalmology.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Retinopathy",
+ "Glucagon-Like Peptides",
+ "Hypoglycemic Agents",
+ "Diabetes Mellitus, Type 2",
+ "Glucagon-Like Peptide-1 Receptor Agonists"
+ ]
+ },
+ {
+ "PMID": "39710882",
+ "Title": "Obesity (Silver Spring, Md.)",
+ "ArticleTitle": "GLP1Ra-based therapies and DXA-acquired musculoskeletal health outcomes: a focused meta-analysis of placebo-controlled trials.",
+ "Abstract": "Approximately 30% of body weight lost with GLP1Ra-based therapy is LM. More data are needed assessing BMD outcomes.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Bone Density",
+ "Glucagon-Like Peptide-1 Receptor",
+ "Absorptiometry, Photon",
+ "Randomized Controlled Trials as Topic",
+ "Body Composition",
+ "Diabetes Mellitus, Type 2",
+ "Bayes Theorem",
+ "Female",
+ "Hypoglycemic Agents",
+ "Male",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39710722",
+ "Title": "European journal of medical research",
+ "ArticleTitle": "Differential seasonal performance of C3-epi-D3 level and proportion on multiple metabolic disorders in patients with type 2 diabetes mellitus.",
+ "Abstract": "Our study releases a seasonally differential impact of C3-epi-D3 levels and proportions on metabolic disorders of T2DM patients, considering to be potentially related to their pathogenesis of different metabolic disorders. The independent association between %C3-epi-D3 and CKD suggests a potential pathological relevance involving C3-epi-D3 itself.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Seasons",
+ "Aged",
+ "Metabolic Diseases",
+ "Calcifediol",
+ "Prospective Studies",
+ "Adult",
+ "Renal Insufficiency, Chronic",
+ "Biomarkers"
+ ]
+ },
+ {
+ "PMID": "39710638",
+ "Title": "BMC ophthalmology",
+ "ArticleTitle": "Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study.",
+ "Abstract": "The risk of young and middle-aged patients with increased as a result of certain patient characteristics and complications, especially lower dietary compliance and physical activity level.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetic Retinopathy",
+ "Risk Factors",
+ "Male",
+ "Female",
+ "Retrospective Studies",
+ "Middle Aged",
+ "Adult",
+ "Young Adult",
+ "Diabetes Mellitus, Type 2",
+ "China"
+ ]
+ },
+ {
+ "PMID": "39710070",
+ "Title": "Diabetes research and clinical practice",
+ "ArticleTitle": "Health disparities in diabetes treatment: The challenge of G6PD deficiency.",
+ "Abstract": "This research highlights serious gaps in the management of G6PD-deficient patients with diabetes, who suffer from insufficient medication management and higher rates of complications. These findings underscore the need to account for G6PD deficiency in diabetes treatment to ensure equitable and effective healthcare for this vulnerable population.",
+ "Predictions": [
+ "Diabetes",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Glucosephosphate Dehydrogenase Deficiency",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Glycated Hemoglobin",
+ "Hypoglycemic Agents",
+ "Adult",
+ "Aged",
+ "Blood Glucose",
+ "Cohort Studies",
+ "Healthcare Disparities",
+ "Diabetes Complications",
+ "Diabetes Mellitus",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39710013",
+ "Title": "Annals of epidemiology",
+ "ArticleTitle": "Gut microbiome and obesity in late adolescence: A case-control study in \"Children of 1997\" birth cohort.",
+ "Abstract": "Adolescents with obesity had a distinct gut microbiota profile compared to the controls, possibly linked to metabolic pertubation and related diseases.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Case-Control Studies",
+ "Female",
+ "Male",
+ "Adolescent",
+ "Pediatric Obesity",
+ "Feces",
+ "Diabetes Mellitus, Type 2",
+ "Birth Cohort",
+ "Bacteroides"
+ ]
+ },
+ {
+ "PMID": "39710002",
+ "Title": "Metabolism: clinical and experimental",
+ "ArticleTitle": "Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.",
+ "Abstract": "Our findings highlight the common genetic underpinnings between type 2 diabetes and muscle loss and frailty and inform drug targets with pleiotropic effects on both of these aging-related challenges.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Genome-Wide Association Study",
+ "Frailty",
+ "Genetic Pleiotropy",
+ "Muscle, Skeletal",
+ "Comorbidity",
+ "Polymorphism, Single Nucleotide",
+ "Female",
+ "Male",
+ "Phenotype",
+ "Aged",
+ "Genetic Predisposition to Disease"
+ ]
+ },
+ {
+ "PMID": "39709941",
+ "Title": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
+ "ArticleTitle": "Positive impact of DPP-4 or SGLT2 inhibitors on mild cognitive impairment in type 2 diabetes patients on metformin therapy: A metabolomic mechanistic insight.",
+ "Abstract": "Mild cognitive impairment is increasingly recognized as a complication of type 2 diabetes (T2D). Although currently no disease-modifying treatments for cognitive disorders exist, interest surged in potential neuroprotective effects of newer anti-diabetic drugs. This study investigates the impact of newer anti-diabetic drug classes, dipeptidyl peptidase-4 (DPP-4i) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) - on cognitive decline in T2D patients on metformin therapy. A prospective observational cohort study was conducted, with a follow-up duration of 6 months. The study compared the cognitive performance of T2D patients on metformin monotherapy to those on a combination of metformin with DPP-4i or SGLT2i, using the Montreal Cognitive Assessment Battery. A group of healthy volunteers served as a reference. At baseline, patients receiving combination therapy had a cognitive performance comparable to that of healthy volunteers, while those on metformin monotherapy scored lower. These differences persisted for patients who completed the follow-up, though there was no change within group. Baseline differences were independent of glycemic control, blood lipids, renal function, and serum inflammatory markers. Comprehensive metabolomics and lipidomics revealed that T2D patients on metformin monotherapy exhibited enriched purine, glutathione and sphingolipid metabolism, with alterations in xanthine, L-pyroglutamic acid, and several sphingomyelins. These changes suggest increased oxidative stress in T2D, mitigated in the combination therapy group, as evidenced by total serum antioxidant capacity. As such, we conclude that the combination of DPP-4i or SGLT2i with metformin positively impacts cognitive function in T2D patients by modulating metabolic pathways rather than improving glycemic control, peripheral diabetic complications, or systemic inflammation.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Aged",
+ "Female",
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Cognition",
+ "Cognitive Dysfunction",
+ "Diabetes Mellitus, Type 2",
+ "Dipeptidyl-Peptidase IV Inhibitors",
+ "Drug Therapy, Combination",
+ "Hypoglycemic Agents",
+ "Metabolomics",
+ "Metformin",
+ "Prospective Studies",
+ "Sodium-Glucose Transporter 2 Inhibitors"
+ ]
+ },
+ {
+ "PMID": "39709924",
+ "Title": "Food chemistry",
+ "ArticleTitle": "Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice.",
+ "Abstract": "Diabetic nephropathy (DN) is one of the most serious and prevalent complications associated with diabetes. Consequently, antidiabetic drugs or foods potentially protecting the kidneys are of significant therapeutic value. Sulforaphene (SFE) is a natural isothiocyanate derived from radish seeds, known for its anti-inflammatory and antioxidant properties. However, no studies have investigated on the ability of SFE to prevent or treat DN. This study established a high-fat diet combined with a streptozotocin-induced type II diabetes mellitus mouse model. We administered SFE treatment to examine its protective effects on renal and intestinal homeostasis in DN mice. After 4\u00a0weeks of treatment, SFE (50\u00a0mg/kg b.w.) not only reduced blood glucose concentration (20.3\u00a0%, P\u00a0<\u00a00.001), kidney to body weight ratio (26.2\u00a0%, P\u00a0<\u00a00.01), and levels of serum total cholesterol (40.6\u00a0%, P\u00a0<\u00a00.001), triglycerides (38.2\u00a0%, P\u00a0<\u00a00.01), creatinine (36.7\u00a0%, P\u00a0<\u00a00.01), and urea nitrogen (45.0\u00a0%, P\u00a0<\u00a00.001) in DN mice compared to control mice but also increased the kidney superoxide dismutase (72.7\u00a0%, P\u00a0<\u00a00.001), catalase (51.1\u00a0%, P\u00a0<\u00a00.001), and glutathione peroxidase activities (31.6\u00a0%, P\u00a0<\u00a00.01), as well as glutathione levels (39.2\u00a0%, P\u00a0<\u00a00.01) in comparison to DN mice. Furthermore, SFE decreased levels of reactive oxygen species (55.4\u00a0%, P\u00a0<\u00a00.01), 4-hydroxyalkenals (36.9\u00a0%, P\u00a0<\u00a00.001), malondialdehyde (42.6\u00a0%, P\u00a0<\u00a00.001), and 8-hydroxy-deoxyguanosine (26.3\u00a0%, P\u00a0<\u00a00.001), accompanied by a meliorating kidney morphological abnormalities. Notably, a reduction in renal inflammatory factors was also observed in SFE-treated DN mice compared to untreated DN mice, particularly in the C-X-C motif chemokine ligand 8 factors (54.8\u00a0%, P\u00a0<\u00a00.001). Western blotting results indicated that SFE significantly down-regulated the protein expression of TLR4 and MyD88 (1.9, 1.7-fold, P\u00a0<\u00a00.001). Additionally, SFE improved gut microbiota (GM) dysbiosis and intestinal homeostasis, as evidenced by increased expression of antimicrobial peptides and tight junction proteins in colon tissue. SFE appeared to enhance the proliferation of probiotics, such as Bacteroidota, Lachnospiraceae_NK4A136_group and norank_f__Muribaculaceae, while also decreasing harmful bacteria to a greater extent compared to STZ treatment. These findings suggest that SFE modulates GM and improves intestinal homeostasis, providing a theoretical basis for its use in the treatment of DN.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Animals",
+ "Mice",
+ "Diet, High-Fat",
+ "Male",
+ "Kidney",
+ "Diabetic Nephropathies",
+ "Gastrointestinal Microbiome",
+ "Dysbiosis",
+ "Isothiocyanates",
+ "Humans",
+ "Mice, Inbred C57BL",
+ "Protective Agents",
+ "Blood Glucose",
+ "Streptozocin",
+ "Sulfoxides",
+ "Diabetes Mellitus, Type 2",
+ "Raphanus",
+ "Oxidative Stress",
+ "Bacteria",
+ "Superoxide Dismutase"
+ ]
+ },
+ {
+ "PMID": "39709670",
+ "Title": "European journal of cancer (Oxford, England : 1990)",
+ "ArticleTitle": "Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors.",
+ "Abstract": "GLP1a use in cancer patients with T2DM receiving ICIs was associated with reduced MACE and all-cause mortality without an increased risk in serious adverse events.",
+ "Predictions": [
+ "Cancer",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Immune Checkpoint Inhibitors",
+ "Retrospective Studies",
+ "Neoplasms",
+ "Aged",
+ "Middle Aged",
+ "Cardiovascular Diseases",
+ "Glucagon-Like Peptide 1",
+ "Diabetes Mellitus, Type 2"
+ ]
+ },
+ {
+ "PMID": "39709519",
+ "Title": "Medical science monitor : international medical journal of experimental and clinical research",
+ "ArticleTitle": "MicroRNAs as Biomarkers for Metabolic Disorders in Polycystic Ovary Syndrome (PCOS): A Review.",
+ "Abstract": "Polycystic ovary syndrome (PCOS) is associated with several mild metabolic disorders, including insulin resistance (IR), obesity, and dyslipidemia, as well as with some more severe ones, including type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. Clinically, mild metabolic complications of PCOS such as IR or lipid metabolism disorders are the predictors of these more severe ones. So far, there is no reliable single marker that enables defining metabolic risk in patients with PCOS. Therefore, novel independent markers of metabolic disturbances are needed. Most reports have focused on microRNA (miRNA, miR) assessment in blood serum or granulosa cells, suggesting the high potential clinical utility of such management. The greatest number of studies focused on the association between miRNAs and IR, obesity, or lipid disorders, and some miRNAs were characteristics of all these processes concomitantly. The altered expression of miR-222, miR-223, miR-320, and miR-122 has been most commonly mentioned as the regulator of these metabolic distortions and seems to result from common regulation pathways of metabolic disturbances. In turn, the current literature lacked the miRNA which could be identified as a reliable marker of type 2 diabetes mellitus or NAFLD accompanying PCOS. Therefore, the main objective of future studies should be determining miRNA markers of these most serious metabolic complications. This article aims to review the role of microRNAs as biomarkers for metabolic disorders in PCOS.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Polycystic Ovary Syndrome",
+ "Female",
+ "MicroRNAs",
+ "Biomarkers",
+ "Metabolic Diseases",
+ "Insulin Resistance",
+ "Non-alcoholic Fatty Liver Disease",
+ "Diabetes Mellitus, Type 2",
+ "Obesity"
+ ]
+ },
+ {
+ "PMID": "39709437",
+ "Title": "Cardiovascular diabetology",
+ "ArticleTitle": "Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation.",
+ "Abstract": "A high level potassium intake estimated from urine potassium excretion was independently associated with a low risk of MACE in patients with type 2 diabetes. Increasing potassium intake may be a potential effective strategy for cardiovascular risk reduction beyond controlling traditional risk factors.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Female",
+ "Male",
+ "Prospective Studies",
+ "Middle Aged",
+ "Risk Assessment",
+ "Aged",
+ "Time Factors",
+ "Potassium, Dietary",
+ "Cardiovascular Diseases",
+ "Reproducibility of Results",
+ "Prognosis",
+ "Biomarkers",
+ "Risk Factors",
+ "Protective Factors",
+ "Albuminuria",
+ "Urinalysis",
+ "Recommended Dietary Allowances"
+ ]
+ },
+ {
+ "PMID": "39709342",
+ "Title": "BMC geriatrics",
+ "ArticleTitle": "A correlation study between blood glucose fluctuation and chronic pain in the older people with type 2 diabetes mellitus.",
+ "Abstract": "ChiCTR1800019107.",
+ "Predictions": [
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 2",
+ "Male",
+ "Female",
+ "Aged",
+ "Blood Glucose",
+ "Chronic Pain",
+ "Middle Aged",
+ "Pain Measurement",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39708996",
+ "Title": "Preventive medicine",
+ "ArticleTitle": "Association between physical activity-related metabolic signature and cardiometabolic diseases and multimorbidity: A cohort study from UK biobank.",
+ "Abstract": "Physical activity-related metabolic signature is linked to reduced risks of CMDs and CMM. We once again emphasize the importance of physical activity for CMDs prevention from a metabolic perspective, especially for individuals at high genetic risk.",
+ "Predictions": [
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "United Kingdom",
+ "Female",
+ "Male",
+ "Exercise",
+ "Middle Aged",
+ "Prospective Studies",
+ "Multimorbidity",
+ "Diabetes Mellitus, Type 2",
+ "Aged",
+ "Cardiovascular Diseases",
+ "Biological Specimen Banks",
+ "Coronary Disease",
+ "Genetic Predisposition to Disease",
+ "Stroke",
+ "Adult",
+ "UK Biobank"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/mental_health.json b/model/dataset/mental_health.json
new file mode 100644
index 0000000000000000000000000000000000000000..6607c9800851bfbf88b7b71a583650772b20a86a
--- /dev/null
+++ b/model/dataset/mental_health.json
@@ -0,0 +1,2328 @@
+[
+ {
+ "PMID": "39738254",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Cross sectional associations of physical activity and sleep with mental health among Chinese university students.",
+ "Abstract": "The intensity of PA among university students is predominantly light, and the reported rate of insufficient sleep is relatively high. Moderate to high-intensity PA and sufficient high-quality sleep may alleviate MH issues among college students, with an interaction effect observed among PA, sleep, and depression symptoms. Future studies should further explore targeted interventions combining PA and sleep behaviors to enhance the MH of university students.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Students",
+ "Female",
+ "Exercise",
+ "Universities",
+ "China",
+ "Mental Health",
+ "Young Adult",
+ "Depression",
+ "Cross-Sectional Studies",
+ "Anxiety",
+ "Sleep",
+ "Surveys and Questionnaires",
+ "Adult",
+ "Adolescent",
+ "Sleep Quality",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39737457",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Impact of COVID-19 vaccination on adolescent and youth students' mental health and bullying behaviors after the lifting of COVID-19 restrictions in China.",
+ "Abstract": "This study suggests that COVID-19 vaccination will not only protect students' physical health, but also improve mental health. It is crucial to explore the mechanism between vaccination and mental health problems and bullying behaviors in further studies.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "China",
+ "COVID-19",
+ "Male",
+ "Female",
+ "Students",
+ "Bullying",
+ "COVID-19 Vaccines",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "Vaccination",
+ "Depression",
+ "Anxiety",
+ "SARS-CoV-2",
+ "Stress Disorders, Post-Traumatic"
+ ]
+ },
+ {
+ "PMID": "39735766",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Unemployment and mental health: a global study of unemployment's influence on diverse mental disorders.",
+ "Abstract": "These findings underscore the critical interplay between socio-economic factors and mental health, highlighting the need for proactive strategies to address the dual burden of unemployment and mental health disorders. Targeted interventions, such as employment support programs and accessible mental health services, are essential to improve global mental health outcomes. These initiatives can also alleviate the economic burden of unemployment by boosting workforce participation and productivity. Long-term economic gains may offset the increased healthcare expenditures associated with mental health support.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Unemployment",
+ "Mental Disorders",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Global Health",
+ "Mental Health",
+ "Young Adult",
+ "Socioeconomic Factors"
+ ]
+ },
+ {
+ "PMID": "39735765",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Public perceptions of digital mental health awareness campaign in the Arab Gulf states: a qualitative thematic analysis.",
+ "Abstract": "Mental illness is a significant public health concern and a leading cause of disability worldwide. Research shows a lack of mental health knowledge and inappropriate practices in the Gulf Cooperation Council (GCC) states. Our study aimed to evaluate individuals' perspectives on mental health by analyzing their responses to a digital campaign directed at GCC adolescents. We conducted a qualitative thematic analysis of comments in response to the Gulf Health Council's mental health campaign. The campaign content was shared on four social media platforms: TikTok, YouTube, Instagram, and X. A total of 2,146 comments were included in the analysis. There was a widespread denial of the existence of mental illness. The comments revealed a lack of understanding and insufficient support for individuals dealing with mental health issues. Stigma and discrimination against people with mental illness were evident in the comments. The general perception was that individuals have control over their mental health, often associating mental illness with weakness and lack of willpower. Mental illness was believed to be caused by religious and moral shortcomings, and religion was viewed as the solution. Some comments highlighted the need to acknowledge mental illness and urged the development of strategies to promote mental health. Our research shows a lack of awareness, stigma, and inadequate resources for individuals dealing with mental health issues. It highlights the importance of addressing barriers to mental healthcare and increasing access to support. Interventions focusing on stigma reduction and promoting acceptance of mental health disorders are crucial and require collaborative efforts from various stakeholders.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mental Disorders",
+ "Qualitative Research",
+ "Adolescent",
+ "Female",
+ "Health Promotion",
+ "Male",
+ "Social Media",
+ "Social Stigma",
+ "Health Knowledge, Attitudes, Practice",
+ "Middle East",
+ "Mental Health",
+ "Public Opinion"
+ ]
+ },
+ {
+ "PMID": "39735755",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "A study of the impact of internet use on the mental health of rural older adults-empirical analysis based on China General Social Survey 2021 data.",
+ "Abstract": "Internet use, social participation, and friend-gathering type participation all have an effect on the mental health of rural older adults. The research results reveal the impact of Internet use on the mental health of rural older adults and its mechanism, which is helpful to provide useful enlightenment for improving the mental health of rural older adults in the Internet era.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Aged",
+ "Rural Population",
+ "Mental Health",
+ "Male",
+ "Female",
+ "Social Participation",
+ "Internet Use",
+ "Surveys and Questionnaires",
+ "Middle Aged",
+ "Aged, 80 and over",
+ "Internet"
+ ]
+ },
+ {
+ "PMID": "39735753",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Chronic impacts of natural infrastructure on the physical and psychological health of university students during and after COVID-19: a case study of Chengdu, China.",
+ "Abstract": "The study emphasizes the importance of incorporating natural elements into urban planning to enhance outdoor activity and well-being, especially in post-pandemic settings. Recommendations are provided for future urban design to address the therapeutic needs of specific populations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "China",
+ "Students",
+ "Universities",
+ "Male",
+ "Female",
+ "Mental Health",
+ "Young Adult",
+ "Adult",
+ "SARS-CoV-2",
+ "City Planning"
+ ]
+ },
+ {
+ "PMID": "39735752",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Effects of a flexibly delivered group-based acceptance and commitment therapy on reducing stress and enhancing psychological wellbeing in parents of school-age children during the COVID-19 pandemic: a quasi-experimental study.",
+ "Abstract": "The findings highlight the potential of group-based Acceptance and Commitment Therapy to alleviate stress and improve psychological well-being in parents of school-age children, regardless of the delivery method, especially during crises such as the COVID-19 pandemic. However, due to limitations in the study design, caution is warranted when interpreting the overall effects of group-based ACT on parent outcomes and the moderating role of delivery methods. Further research is needed to validate these findings and explore the nuances of delivery methods in similar real-world situations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Acceptance and Commitment Therapy",
+ "Female",
+ "Male",
+ "Parents",
+ "Stress, Psychological",
+ "Adult",
+ "Child",
+ "Hong Kong",
+ "Middle Aged",
+ "SARS-CoV-2",
+ "Psychotherapy, Group",
+ "Pandemics",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39735743",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "The impact of university freshmen's mental health on academic performance: an empirical study based on M University in Fujian Province, China.",
+ "Abstract": "University officials should strengthen mental health surveillance and intervention during the first few years of student enrollment to mitigate the harmful impact of mental health issues on academic performance. The moderate to strong effect sizes for variables like somatization, depression, and anxiety indicate that early interventions could be crucial in reducing their negative impact on both short-and long-term academic outcomes. Furthermore, the study discovered disparities in mental health and academic performance across students of different genders and enrollment years, emphasizing that educational personnel should design more tailored mental health support methods that consider these differences.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Universities",
+ "Male",
+ "Female",
+ "China",
+ "Students",
+ "Academic Performance",
+ "Mental Health",
+ "Young Adult",
+ "Depression",
+ "Anxiety",
+ "Adolescent",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39735742",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Effects of volcanic eruptions on the mental health of exposed populations: a systematic review.",
+ "Abstract": "The negative influence of experiencing volcanic activity on mental health was confirmed. Clearly, there is a need for more research to improve the mental health of the populations highly exposed to volcanic eruptions. Recommendations for future research are also included.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Volcanic Eruptions",
+ "Humans",
+ "Mental Health",
+ "Mental Disorders",
+ "Environmental Exposure"
+ ]
+ },
+ {
+ "PMID": "39734104",
+ "Title": "Journal of research on adolescence : the official journal of the Society for Research on Adolescence",
+ "ArticleTitle": "LGBTQ+ youth policy and mental health: Indirect effects through school experiences.",
+ "Abstract": "The link between state policies and LGBTQ+ youth mental health is well-established, yet less well-understood are the mechanisms that drive these associations. We used a sample from the LGBTQ+ National Teen Survey (n\u2009=\u20098368) collected in 2022 to examine whether and to what degree LGBTQ+ inclusive school strategies, student perceptions of school safety, and experiences with bias-based bullying and peer victimization explain the association between state LGBTQ+ youth-focused policies and LGBTQ+ youth mental health symptomology. We observed significant indirect effects between policy and LGBTQ+ youth mental health through all four constructs, suggesting that each of these more proximal school experiences was independently implicated in this association. Findings underscore how state policies shape LGBTQ+ youth mental health symptomology via more proximal contexts and emphasize the importance of policy implementation following enactment.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Male",
+ "Sexual and Gender Minorities",
+ "Female",
+ "Schools",
+ "Bullying",
+ "Mental Health",
+ "Crime Victims",
+ "United States",
+ "Surveys and Questionnaires",
+ "Students",
+ "Peer Group"
+ ]
+ },
+ {
+ "PMID": "39734100",
+ "Title": "Journal of research on adolescence : the official journal of the Society for Research on Adolescence",
+ "ArticleTitle": "Adolescents in various contexts during the COVID-19 pandemic: A commentary.",
+ "Abstract": "This commentary provides a reflection on the impact of the COVID-19 pandemic on adolescents in the context of family dynamics, school environments, peer relationships, and civic engagement. Drawing from four systematic literature reviews, the commentary highlights key findings, such as the long-term effects of COVID-19 on adolescent development, mental health, and academic well-being. The need for future research is emphasized to assess how these cohort effects will evolve over time. Cultural context and socioeconomic disparities emerge as crucial considerations, with the pandemic exacerbating existing inequalities, especially in access to education and digital resources. This commentary also underscores the importance of adopting a socio-ecological perspective to understand the multifaceted impact of COVID-19 on adolescents globally. In conclusion, it calls for targeted policies to support adolescents' mental health and academic recovery post-pandemic, particularly in underserved communities. Governments, educators, and civic organizations are encouraged to create inclusive policies that address these disparities while fostering resilience and well-being among young people. These reviews may also inform translational research that could aid in the development of evidence-based interventions and policies aimed at helping adolescents thrive in a post-pandemic world.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Adolescent",
+ "Mental Health",
+ "SARS-CoV-2",
+ "Adolescent Development",
+ "Pandemics",
+ "Peer Group",
+ "Socioeconomic Factors"
+ ]
+ },
+ {
+ "PMID": "39732736",
+ "Title": "BMC psychology",
+ "ArticleTitle": "Factorial validation and invariance of the Academic Procrastination Scale in Colombian students.",
+ "Abstract": "The Modified Academic Procrastination Scale (EPA-C) demonstrates adequate psychometric properties and is gender-invariant for assessing academic procrastination among Colombian university students. Moreover, it has an impact on the mental health and life satisfaction of these students.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Colombia",
+ "Students",
+ "Young Adult",
+ "Adult",
+ "Adolescent",
+ "Psychometrics",
+ "Personal Satisfaction",
+ "Universities",
+ "Procrastination",
+ "Reproducibility of Results",
+ "Mental Health",
+ "Surveys and Questionnaires",
+ "Factor Analysis, Statistical"
+ ]
+ },
+ {
+ "PMID": "39732545",
+ "Title": "Endocrinologia, diabetes y nutricion",
+ "ArticleTitle": "Nurse-led therapeutic patient education program on glycemic control and emotional wellbeing in adolescents with type 1 diabetes mellitus during hospital transition.",
+ "Abstract": "The structured therapeutic education program for adolescents with T1DM transitioning from pediatric to adult care maintains glycemic control and emotional wellbeing.",
+ "Predictions": [
+ "Mental Health",
+ "Diabetes type 1"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Diabetes Mellitus, Type 1",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Patient Education as Topic",
+ "Glycemic Control",
+ "Transition to Adult Care",
+ "Self Care",
+ "Emotions",
+ "Mental Health",
+ "Feeding and Eating Disorders"
+ ]
+ },
+ {
+ "PMID": "39731523",
+ "Title": "Sociology of health & illness",
+ "ArticleTitle": "Extending Fundamental Cause Theory to Holistic Health.",
+ "Abstract": "Fundamental Cause Theory (FCT) offers a unique middle range and longitudinal understanding of the lasting social causational relationships between certain social conditions and disease/death. In this research note, I argue that FCT should extend its outcome measures beyond physical disease and death into holistic health. I briefly review how FCT is evaluated, explore the proposed extension and discuss some operational and conceptual challenges using mental illness and positive mental health outcomes as exemplars. I conclude by discussing the benefits of extending FCT for 1) the theory's own validity, 2) social health inequalities research more broadly, and 3) public health policy.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Holistic Health",
+ "Mental Disorders",
+ "Health Policy",
+ "Social Theory",
+ "Mental Health",
+ "Health Status Disparities"
+ ]
+ },
+ {
+ "PMID": "39731316",
+ "Title": "Nordic journal of psychiatry",
+ "ArticleTitle": "Gender-stratified national mental health norms of BSI-53, BSI-18, SCL-10, ADHD-9, and ADHD-6 for Denmark.",
+ "Abstract": "This study provides gender-stratified Danish mental health norms for multiple symptom scales. The considerable gender differences in the SCL-10 underscore the importance of gender-specific norms. The 2020 SCL-10 norms are biased by COVID-19 distress. Until new normative data is available, the gender-specific norms provided here are recommended.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Denmark",
+ "Female",
+ "Male",
+ "Attention Deficit Disorder with Hyperactivity",
+ "Adult",
+ "Middle Aged",
+ "Adolescent",
+ "Young Adult",
+ "Aged",
+ "COVID-19",
+ "Sex Factors",
+ "Aged, 80 and over",
+ "Reference Values",
+ "Brief Psychiatric Rating Scale",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39730730",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Insights into adolescent sleep and mental health in rural area of Northwestern China.",
+ "Abstract": "Adolescents in affluent nations have experienced a decline in sleep duration, associated with adverse outcomes such as behavioral issues and health concerns. However, the connection between sleep and mental well-being during adolescence, particularly in developing regions like rural China, remains underexplored. A cross-sectional study of 18,516 adolescents in 124 junior high schools in Ningxia, China, utilized the strengths and difficulties questionnaire to assess mental health. The findings highlighted a complex, nonlinear link between sleep duration and mental health, with a U-shaped trend for overall difficulties and an inverse U-shape for prosocial behavior. The study also explored potential mechanisms behind these relationships, suggesting that time allocation to activities such as screen time and outdoor activities could mediate the effects of sleep duration on mental health. Longer sleep durations could lead to less screen time and more outdoor engagement, both of which positively affect mental well-being. Balanced sleep duration is crucial for adolescent mental health. The study calls for interventions to improve sleep hygiene and mental health services in rural areas, emphasizing the need for policy support to address sleep deprivation and its impact on mental well-being.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "China",
+ "Male",
+ "Mental Health",
+ "Female",
+ "Rural Population",
+ "Sleep",
+ "Cross-Sectional Studies",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39730531",
+ "Title": "Scientific reports",
+ "ArticleTitle": "A chain-mediated model of the effect of physical exercise on loneliness.",
+ "Abstract": "The physical and mental health development of college students has gradually become an important topic of social concern. The academic community focuses on different ways of physical exercise to improve the mental health of college students. On the basis of sports psychology, this paper discusses the interaction mechanism between physical activity and social support, interpersonal relationship quality and loneliness of college students, that is, physical and mental health effects of physical activities to promote the psychological level of college students. By random sampling, 784 college students were investigated and analyzed with physical exercise scale, loneliness scale, interpersonal relationship scale and social support scale, based on the general characteristics of the demographics variables, and through the analysis of multiple regression path model, this paper further explored the mechanism of the effects of physical activity, social support, loneliness and interpersonal relationship quality of college students. The results showed that physical exercise had a negative predictive effect on loneliness(\u03b2 = -\u00a00.246, p<0.01) and a positive predictive effect on interpersonal relationship quality and social support(\u03b2\u2009=\u20090.186, p<0.01; \u03b2\u2009=\u20090.156, p<0.01).In addition, social support and interpersonal relationship quality play a mediating role between physical exercise and loneliness, including three mediating paths, namely, social support and interpersonal relationship quality play an independent mediating role, the link mediating effect of social support and interpersonal relationship quality. According to the theory of psychological needs, the results show that physical exercise has an indirect effect on loneliness of college students through the chain mediating effect of interpersonal relationship quality and social support. College students can improve the level of social support and the quality of interpersonal relationships, and reduce the sense of loneliness.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Loneliness",
+ "Humans",
+ "Exercise",
+ "Male",
+ "Female",
+ "Social Support",
+ "Students",
+ "Young Adult",
+ "Interpersonal Relations",
+ "Adult",
+ "Adolescent",
+ "Universities",
+ "Mental Health",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39730236",
+ "Title": "Sleep medicine",
+ "ArticleTitle": "Mental health and sleep routines: Uttarkashi, India tunnel collapse workers' experience.",
+ "Abstract": "Among the mental health outcomes and disaster types (determined by damage to life, property, long-term consequences, displacement, and unpredictability), floods are associated with anxiety and sleep problems, mudslides with anxiety and mood disturbance, volcanic eruptions with acute stress reactions, and earthquakes with anxiety, depression, and physical complaints. Disasters such as tunnel collapse are unique as it involves the healthy, without loss of personal property or displacement; hence, they can have very different health-related outcomes. In this study, we explore mental health and sleep-related issues in workers rescued from an under-construction collapsed tunnel trapped for 17 days. After the initial triage and stabilization and a detailed evaluation of their physical and mental health status, the participants responded to self-administered scales for assessing anxiety [Generalized Anxiety Disorder-7], depression [Patient Health Questionnaire-9], and insomnia [Insomnia Severity Index] in the local language (Hindi). A separate research team conducted open-ended interviews to explore daily routines and concerns, circadian rhythm, orientation to time and day of tunnel collapse to day of rescue events, and sleep routine (and other nuances such as sleep quality and daytime napping) during the 17 days of entrapment. Thirty-three workers consented and hailed from the northern and eastern states of India. They report a mix of hope and worry in the initial days. On the assessment of anxiety, depression, and sleep, only 2-5 scored above the cut-off value, and scales correlated with each other, though clinically it had no bearing. One-third were disoriented to the passage of time, which was related to difficulty falling asleep and more napping. Daytime napping was associated with delayed waketime. Those depressed had more difficulty in the onset, maintinance, and termination of sleep, and reduced total sleep time. Victims of tunnel collapse experience a different set of mental health and sleep problems compared to those reported in other disasters. The findings can partly be attributed to the disruption of light-dark cycles. As only a fraction develops these problems, there is a need for triaging while providing mental health and sleep-related interventions in such circumstances. Lastly, there is a need to establish a light-dark cycle to prevent disorientation among victims.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Male",
+ "Adult",
+ "Female",
+ "Anxiety",
+ "Mental Health",
+ "Middle Aged",
+ "Disasters",
+ "Depression",
+ "Sleep Initiation and Maintenance Disorders",
+ "Sleep",
+ "Surveys and Questionnaires",
+ "Circadian Rhythm"
+ ]
+ },
+ {
+ "PMID": "39729870",
+ "Title": "Environment international",
+ "ArticleTitle": "Life in green: Associations between greenspace availability and mental health over the lifecourse - A 40-year prospective birth cohort study.",
+ "Abstract": "This study supports the protective effects of greenspace on adult depressive symptoms, highlighting the significance of employing a spatial lifecourse epidemiology framework to examine the long-term effects of environmental factors on health over the lifecourse.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "New Zealand",
+ "Prospective Studies",
+ "Adult",
+ "Mental Health",
+ "Male",
+ "Female",
+ "Child",
+ "Young Adult",
+ "Infant",
+ "Child, Preschool",
+ "Birth Cohort",
+ "Parks, Recreational",
+ "Infant, Newborn",
+ "Depression"
+ ]
+ },
+ {
+ "PMID": "39729805",
+ "Title": "Drug and alcohol dependence",
+ "ArticleTitle": "Tobacco cessation, mental health, and substance use in a community pharmacist-linked cessation program for people experiencing homelessness.",
+ "Abstract": "A community pharmacist-linked cessation program in homeless shelters was associated with reduced consumption and increased weekly quit attempts, highlighting its potential for scalability among people experiencing homelessness with high rates of co-occurring behavioral health conditions.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Adult",
+ "Community Pharmacy Services",
+ "Community-Based Participatory Research",
+ "Ill-Housed Persons",
+ "Tobacco Use Cessation",
+ "Mental Health",
+ "Substance-Related Disorders",
+ "Program Evaluation",
+ "San Francisco",
+ "Counseling",
+ "Nicotine Replacement Therapy",
+ "Mentoring",
+ "Tobacco Products",
+ "Tobacco Use",
+ "Odds Ratio",
+ "Poisson Distribution",
+ "Logistic Models",
+ "Time Factors",
+ "Diagnosis, Dual (Psychiatry)",
+ "Mental Disorders"
+ ]
+ },
+ {
+ "PMID": "39727705",
+ "Title": "Current oncology (Toronto, Ont.)",
+ "ArticleTitle": "Longitudinal Follow-Up of the Psychological Well-Being of Patients with Colorectal Cancer: Final Analysis of PICO-SM.",
+ "Abstract": "PICO-SM was a prospective longitudinal study investigating the psychological impact of the COVID-19 pandemic on patients with colorectal cancer treated in a large UK tertiary cancer centre. Here, we present the impact of the third wave of the pandemic (December 2021 to February 2022), when the Omicron variant became prevalent in the UK, and the complete longitudinal comparison across the entire duration of this study. Patients were invited to complete a questionnaire, including screening psychometric tools. In total, n = 312 patients were included in the final analysis. Specifically, in this Omicron-predominant wave, n = 96 patients were studied in detail: the mean age was 64 years, 64% were male, 33% reported poor well-being, 27% anxiety, 11% depressive symptoms, and 3% trauma-related symptoms. The participants who had investigations cancelled (OR 9.22, 95% CI 1.09-77.85; ",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Colorectal Neoplasms",
+ "Middle Aged",
+ "COVID-19",
+ "Female",
+ "Longitudinal Studies",
+ "Aged",
+ "Anxiety",
+ "Prospective Studies",
+ "SARS-CoV-2",
+ "Depression",
+ "Follow-Up Studies",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "United Kingdom",
+ "Psychological Well-Being"
+ ]
+ },
+ {
+ "PMID": "39727168",
+ "Title": "European journal of pain (London, England)",
+ "ArticleTitle": "Monitoring Chronic Non-Cancer Pain in Denmark Over Two Decades: Prevalence, Mental Health and Loneliness.",
+ "Abstract": "This study demonstrated alarming trend on chronic non-cancer pain prevalence over time in Denmark. The high estimates of prevalence and related issues, such as mental health and severe loneliness deserve further investigation and prioritisation in the public health agenda.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Denmark",
+ "Loneliness",
+ "Female",
+ "Middle Aged",
+ "Male",
+ "Chronic Pain",
+ "Prevalence",
+ "Adult",
+ "Aged",
+ "Mental Health",
+ "COVID-19",
+ "Young Adult",
+ "Adolescent",
+ "Aged, 80 and over",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39727091",
+ "Title": "JMIR mental health",
+ "ArticleTitle": "Implementing Findable, Accessible, Interoperable, Reusable (FAIR) Principles in Child and Adolescent Mental Health Research: Mixed Methods Approach.",
+ "Abstract": "By systematically listing these barriers and providing recommendations, we intend to enhance the awareness of researchers and grant providers that making data FAIR demands specific expertise, available tooling, and proper investments.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Child",
+ "Mental Health",
+ "Biomedical Research",
+ "Delphi Technique",
+ "Mental Health Services"
+ ]
+ },
+ {
+ "PMID": "39726658",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Increased physical activity frequency in primary school adolescents is related to reduced risk of self-reported adverse mental health symptoms.",
+ "Abstract": "Given the dose-response relationship between poor mental health and lack of physical activity, it is necessary to actively promote primary school students to participate more actively in physical activities.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Exercise",
+ "Self Report",
+ "Adolescent",
+ "Students",
+ "China",
+ "Child",
+ "Schools",
+ "Mental Health",
+ "Surveys and Questionnaires",
+ "Health Surveys",
+ "Sedentary Behavior",
+ "Depression"
+ ]
+ },
+ {
+ "PMID": "39726069",
+ "Title": "The International journal of artificial organs",
+ "ArticleTitle": "Comparing mental health and substance use disorders in patients receiving durable VADs versus transplants: A TriNetX database analysis.",
+ "Abstract": "Ventricular assist device (VAD) and cardiac transplant patients experience significant strain on their physical and mental wellbeing postoperatively. Mental health and substance use disorders (MHDs and SUDs) have substantial effects on the quality of life and compliance of transplant and VAD patients. In this study, we compare and characterize MHDs and SUDs between VAD and cardiac allograft patients and transplant list patients with and without VADs. This study compares the incidence of MHDs and SUDs between VAD and cardiac transplant patients. Cohorts were defined using ICD-10 codes in TriNetX, a large public database. Patient characteristics were matched by using propensity score matching. Incidence was analyzed using the log-rank test. Statistical significance was set at ",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Substance-Related Disorders",
+ "Middle Aged",
+ "Heart Transplantation",
+ "Heart-Assist Devices",
+ "Adult",
+ "Databases, Factual",
+ "Incidence",
+ "Mental Health",
+ "Quality of Life",
+ "Aged",
+ "Mental Disorders",
+ "Waiting Lists",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39725888",
+ "Title": "BMC pregnancy and childbirth",
+ "ArticleTitle": "Mental health risks in pregnancy and early parenthood among male and female parents following unintended pregnancy or fertility treatment: a cross-sectional observational study.",
+ "Abstract": "N/A (non-interventional study).",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Pregnancy",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Pregnancy, Unplanned",
+ "Parents",
+ "Mental Health",
+ "Reproductive Techniques, Assisted",
+ "Young Adult",
+ "Stress, Psychological",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39725758",
+ "Title": "Brain and nerve = Shinkei kenkyu no shinpo",
+ "ArticleTitle": "[Adolescent Mental Health during and beyond the COVID-19 Pandemic].",
+ "Abstract": "During the COVID-19 pandemic, deterioration of adolescent mental health was observed worldwide. In Japan, the impact of COVID-19 on adolescent mental health was more severe among boys than girls and in the later phases of the pandemic. An increased number of adolescent suicides was also reported. In this paper, I outline possible reasons for the observed phenomenon and conclude that continuous monitoring and interventions to promote help-seeking among adolescents are required.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Adolescent",
+ "Mental Health",
+ "Pandemics",
+ "SARS-CoV-2",
+ "Japan",
+ "Male",
+ "Suicide",
+ "Female",
+ "Mental Disorders"
+ ]
+ },
+ {
+ "PMID": "39724226",
+ "Title": "PloS one",
+ "ArticleTitle": "Psychosocial work stressors and mental health in Ph.D. students in Germany-Evidence from two cross-sectional samples.",
+ "Abstract": "Both study samples showed high prevalence of mental health symptoms and effort-reward imbalance also in comparison to other research findings. An imbalance between effort and reward, boundary permeability and leader support show the most strongly associations with mental health symptoms and perceived stress. Future longitudinal studies could help to support our findings in terms of a causal stressor-strain association. Universities should focus on mental health of Ph.D. students and direct their support towards promoting student-supervisor relationships and clear guidelines for Ph.D. students' working hours.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Germany",
+ "Cross-Sectional Studies",
+ "Mental Health",
+ "Adult",
+ "Surveys and Questionnaires",
+ "Young Adult",
+ "Stress, Psychological",
+ "Students",
+ "Occupational Stress",
+ "Universities"
+ ]
+ },
+ {
+ "PMID": "39724125",
+ "Title": "Psychiatria Danubina",
+ "ArticleTitle": "MENTAL HEALTH OUTCOMES IN COVID-19 SURVIVORS: ROLE OF CLINICAL PREDICTORS.",
+ "Abstract": "The COVID-19 pandemic had a major worldwide impact resulting in more than 7 million deaths due to COVID-19. Mental health issues, including anxiety, depression, and post-traumatic stress disorder (PTSD) have been observed in COVID-19 survivors worldwide. This study aimed to investigate the psychological impact of COVID-19 survivors three months after discharge from hospital and examine associated risk factors. 186 COVID-19 patients were assessed at baseline and three months after hospital discharge using questionnaires for depression, anxiety, insomnia, and post-traumatic stress symptoms (PTSD). Medical data, including comorbidities, complications, and psychiatric history, were collected, and analyzed. The study found a prevalence of PTSD, anxiety, and depression symptoms of 14%, 14% and 10.8% respectively three months after hospital discharge. Female gender was a risk factor for PTSD (OR 4.54), depression (OR 3.55) and anxiety (OR 3.06). Patients with psychiatric history were at higher risk of depression (OR 8.46) and anxiety (OR 4.00) but not of PTSD. No association was found with other clinical variables including inflammation markers. The prevalence of psychopathological outcomes in COVID-19 survivors in this study was increased compared to the general population and in line with previous research. Female gender and psychiatric history increased the risk of anxiety and depression. The absence of correlation between inflammation or other clinical variables and psychopathological outcome measures is discussed in comparison with prior research. More research is needed to understand these associations and the long-term effects of COVID-19 on mental health.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Female",
+ "Male",
+ "Stress Disorders, Post-Traumatic",
+ "Survivors",
+ "Middle Aged",
+ "Adult",
+ "Anxiety",
+ "Risk Factors",
+ "Depression",
+ "Prevalence",
+ "Aged",
+ "Comorbidity",
+ "Sex Factors",
+ "Sleep Initiation and Maintenance Disorders",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39724115",
+ "Title": "Psychiatria Danubina",
+ "ArticleTitle": "GLOBAL MENTAL HEALTH ENLIGHTENMENT AND CULTURE OF EMPATHY: HOW TO NAVIGATE A WORLD IN EXISTENTIAL CRISIS AND WARS?",
+ "Abstract": "A global culture of empathy appears crucial for the survival of humankind and life on our planet. There is no health without mental health and no mental health without a culture of empathy at all levels: individual, family, national, and global. Similarly, there is no global security without peace, and no peace without a culture of empathy. While peace is associated with mental health promotion, wars are associated with poor or ill mental health. Humanity needs a fresh goal for global peace and sustainability that promotes the culture of empathy to prevent millions of innocent victims from dying, becoming ill, or being maimed. Education focusing on empathy, peace, and mental health literacy forms the foundation for a better future for all and Earth's sustainability. If we, as Homo sapiens - beings capable of foresight, choice, and action - are to survive, there must be New Enlightenment: a positive vision of an empathetic form of globalization for all humankind.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Empathy",
+ "Global Health",
+ "Mental Health",
+ "Existentialism",
+ "Warfare"
+ ]
+ },
+ {
+ "PMID": "39724057",
+ "Title": "PloS one",
+ "ArticleTitle": "Depression in the COVID-19 endemic era: Analysis of online self-disclosures by young South Koreans.",
+ "Abstract": "Although COVID-19 has been declared endemic in South Korea, there are economic and psychosocial after-effects. One of these is the prevalence of depression. Depressed adolescents and young adults struggle with insecurity, loneliness, and lack of confidence due to the life limitations imposed during the pandemic. Young South Koreans experienced deterioration in mental health because of the recurrence of mass infections. To address professionals' concerns about the lingering effects of COVID-19 on youth mental health, we text-mined young South Koreans' online posts about depression during the pandemic and the endemic phases-from February 2020 to May 2023. We used a total of 1,740 selected posts (raw data publicly available on https://github.com/kimalexis1129/PLOS_endemic_depression.git) to explore the situational triggers, additional factors, and by-products of depression that have persisted during the endemic era. We used Latent Dirichlet allocation and Dirichlet-multinomial regression topic modeling methods in conjunction with sentiment analysis and mean comparison. The results showed that the pandemic and endemic topic models shared similarities, but emerging topics showed extended adversities such as adolescents' vulnerability to eating disorders and young adults' tendency to self-isolate. Comparisons between the levels of positive and negative affect during the pandemic and endemic eras revealed no significant changes in mood. We discussed the results in comparison with SARS and MERS precedents and from general and cultural perspectives.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Adult",
+ "Female",
+ "Humans",
+ "Male",
+ "Young Adult",
+ "COVID-19",
+ "Depression",
+ "East Asian People",
+ "Mental Health",
+ "Pandemics",
+ "Republic of Korea",
+ "Social Media"
+ ]
+ },
+ {
+ "PMID": "39722713",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Multidimensional screen exposure and its impact on psychological well-being in toddlers.",
+ "Abstract": "The amount of time spent using computers, mobile phones and VR devices and the proportion of exposure to noneducational content and fast-paced content were significantly associated with psychological problems among 2- to 3-year-old children.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Child, Preschool",
+ "Cross-Sectional Studies",
+ "China",
+ "Screen Time",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "Parents",
+ "Psychological Well-Being"
+ ]
+ },
+ {
+ "PMID": "39722022",
+ "Title": "BMC public health",
+ "ArticleTitle": "Combating the mental health challenge of loneliness among urban youth: could finding meaning in life and experiencing thriving enhance their well-being?",
+ "Abstract": "The findings suggest that cultivating a sense of meaning in life is crucial for reducing loneliness and promoting well-being among urban youth. Educational institutions and mental health agencies should develop programs that help individuals find and pursue meaningful activities to foster thriving. Future research should explore these dynamics in various cultural contexts and utilize longitudinal designs to confirm causality.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Loneliness",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Urban Population",
+ "Young Adult",
+ "Adult",
+ "Mental Health",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39720811",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "The impact of positive activities on mental health: the mediating role of positive emotion.",
+ "Abstract": "We concluded that the participation level of positive activities still needs to be improved and positive activities improve mental health through positive emotion, which implied that positive activities, as an easily implementable measure, should be greatly encouraged in mental health policies. And older adults, female, people without spouse, middle and upper-middle-income individuals need to be paid more attention.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Mental Health",
+ "China",
+ "Middle Aged",
+ "Adult",
+ "Emotions",
+ "Surveys and Questionnaires",
+ "Aged",
+ "Adolescent",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39719817",
+ "Title": "Journal of psychosomatic research",
+ "ArticleTitle": "Boosting integration of physical and mental health: The impact of increasing psychiatrists in general hospitals without psychiatric Ward.",
+ "Abstract": "Despite often being underestimated due to cost constraints, having multiple full-time psychiatrists in a general hospital without a psychiatric ward is essential for supporting the broader scope needed to integrate physical and mental health services.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Hospitals, General",
+ "Psychiatry",
+ "Mental Health Services",
+ "Japan",
+ "Psychiatric Department, Hospital",
+ "Referral and Consultation",
+ "Mental Disorders",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "Psychiatrists"
+ ]
+ },
+ {
+ "PMID": "39719755",
+ "Title": "Environment international",
+ "ArticleTitle": "The impact of long-term exposure to NO",
+ "Abstract": "Recent increases in nitrogen dioxide (NO",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Humans",
+ "Ozone",
+ "Mental Health",
+ "Nitrogen Dioxide",
+ "Male",
+ "Female",
+ "Child",
+ "China",
+ "Air Pollutants",
+ "Environmental Exposure",
+ "Schools",
+ "Cross-Sectional Studies",
+ "Air Pollution",
+ "Students"
+ ]
+ },
+ {
+ "PMID": "39719653",
+ "Title": "BMC psychology",
+ "ArticleTitle": "Would you be healthier if you had more social capital? Focusing on university students' social media use in Japan.",
+ "Abstract": "This study has implications for improving the health of young adults in the \"mobile x social era.\" In particular, we provide suggestions to help young adults improve their mental health.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Social Capital",
+ "Students",
+ "Social Media",
+ "Japan",
+ "Universities",
+ "Male",
+ "Female",
+ "Young Adult",
+ "Mental Health",
+ "Adult",
+ "Loneliness",
+ "Health Status",
+ "Personality",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39716066",
+ "Title": "BMC cardiovascular disorders",
+ "ArticleTitle": "Quality of life after myocardial infarction in the pakistani population - insights from a single-center cohort study.",
+ "Abstract": "Although a significant proportion of patients in our cohort reported good HRQoL post-MI, several social factors were associated with lower HRQoL. These factors must be investigated further in discharge planning and post-discharge of patients with MI.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Quality of Life",
+ "Pakistan",
+ "Myocardial Infarction",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Aged",
+ "Health Status",
+ "Risk Factors",
+ "Mental Health",
+ "Time Factors"
+ ]
+ },
+ {
+ "PMID": "39715637",
+ "Title": "BMJ mental health",
+ "ArticleTitle": "Data sharing in circadian rhythm and mental health research: current status, challenges, recommendations and future directions.",
+ "Abstract": "Data sharing is a cornerstone of modern scientific research, playing a critical role in fostering greater collaboration, enhancing reproducibility, transparency and efficiency of scientific discoveries, and integrating diverse data sources. In circadian rhythm research, data sharing is particularly important due to the complexity and heterogeneity of the data, which includes molecular profiles, physiological measurements, clinical data and sensor-based data. UK research funders, such as Medical Research Council, Wellcome Trust and UK Research and Innovation, have established data-sharing policies to promote open science and enhance research transparency. Despite these policies, a recent assessment within the UK Circadian Mental Health Network (CMHN), which incorporates an analysis of publications from several countries, revealed that data sharing remains limited. Significant challenges including data complexity, privacy and ethical considerations, technical issues and entrenched academic culture are major barriers to progress. This perspective article highlights the current state of data sharing in circadian and mental health research, identifies key obstacles and compares these practices with broader trends. We also provide insights from principal investigators within the CMHN on the reasons for limited data sharing. To address these challenges, researchers can foster a culture of openness by seeking training, planning ahead in ethics processes and data management plans and using data outputs in research assessment. We outline CMHN's future plans to deliver training on Findable, Accessible, Interoperable, Reusable principles, offer data curation services and provide ethical guidelines. By adopting these strategies, we aim to improve data-sharing practices, ultimately advancing our understanding of circadian rhythms and their implications for mental health.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biomedical Research",
+ "Circadian Rhythm",
+ "Information Dissemination",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39715235",
+ "Title": "PloS one",
+ "ArticleTitle": "A comparative study of Venezuelan immigrants' pre- and post-migration concerns for their children in the United States and Colombia.",
+ "Abstract": "Research suggests that forced migration may lead to cultural stress and psychological distress. However, little is known about immigrant parents' pre- and post-migration concerns for their children's welfare. The present study examined the concerns of Venezuelan parents who migrated to the United States versus those who migrated to Colombia, and whether post-migration concerns were related to cultural stressors, mental health, and cultural identity. A sample of 609 Venezuelan immigrants completed surveys and responded to an open-ended prompt asking about pre- and post-migration concerns for children's welfare. Lack of safety was the most common pre-migration concern for Venezuelans in the U.S., whereas lack of food was the most common pre-migration concern for Venezuelans in Colombia. More years in the destination country since arrival were linked to heightened economic concerns and reduced worries about family separation. A positive link emerged between national identity and health-related concerns for children following migration. This knowledge can inform policies and programs to better support immigrant families as they navigate the challenges of forced migration.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Colombia",
+ "Emigrants and Immigrants",
+ "Venezuela",
+ "Female",
+ "Male",
+ "United States",
+ "Child",
+ "Adult",
+ "Child Welfare",
+ "Parents",
+ "Stress, Psychological",
+ "Surveys and Questionnaires",
+ "Adolescent",
+ "Middle Aged",
+ "Mental Health",
+ "Child, Preschool"
+ ]
+ },
+ {
+ "PMID": "39715113",
+ "Title": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
+ "ArticleTitle": "Impact of the Covid-19 pandemic and state of war on the availability and quality of mental health services.",
+ "Abstract": "Conclusions: Preparing for pandemics and public health crises is critical to ensuring access to mental health care and requires a comprehensive approach.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Ukraine",
+ "Mental Health Services",
+ "Health Services Accessibility",
+ "Pandemics",
+ "Quality of Health Care",
+ "SARS-CoV-2",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39714844",
+ "Title": "JAMA network open",
+ "ArticleTitle": "Patterns of Social Connection Among Older Adults in England.",
+ "Abstract": "This cohort study highlights the importance of considering multidimensional measures of social connection and understanding the nuance of its heterogenous patterns. Understanding the typologies of social connection has substantial implications for exploring modifiable risk factors for social disconnection and for understanding the mechanisms linking social connection to health-related outcomes.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Aged",
+ "England",
+ "Middle Aged",
+ "Longitudinal Studies",
+ "Personal Satisfaction",
+ "Cohort Studies",
+ "Depression",
+ "Mental Health",
+ "Health Status",
+ "Social Support",
+ "Health Behavior",
+ "Cluster Analysis"
+ ]
+ },
+ {
+ "PMID": "39713741",
+ "Title": "Alcohol research : current reviews",
+ "ArticleTitle": "Structural Stigma, Racism, and Sexism Studies on Substance Use and Mental Health: A Review of Measures and Designs.",
+ "Abstract": "The structural determinant measures used in the studies reviewed were diverse. They addressed, for example, community opinions, the gender of legislators, economic vulnerability, financial loan discrimination, college policies, law enforcement, historical trauma, and legislative protections for sexual and gender minorities and for reproductive rights. Most of the structural determinant measures were constructed by combining multiple indicators into indexes or by merging indexes into composite indexes, although some studies relied on single indicators alone. The substance use and mental health outcome measures most frequently examined were related to alcohol and depression, respectively. The studies were conducted in numerous nations and drew samples from an array of groups, including, for example, patients who experienced overdoses from substance use, sexual and gender minorities, racial and ethnic minority groups, women, youth, migrants, and patients subject to involuntary psychiatric hospitalization. Most of the studies used passive-observational (correlational) research designs and, as a result, did not assess whether their structural determinant variables were causally related to substance use and mental health. Nevertheless, the studies reviewed can be used by public health proponents to foster awareness that a wide range of structural determinants correlate with the substance use and mental health of many groups within and across nations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Substance-Related Disorders",
+ "Social Stigma",
+ "Sexism",
+ "Mental Health",
+ "Racism",
+ "Mental Disorders"
+ ]
+ },
+ {
+ "PMID": "39712316",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Impact of living arrangements and internet use on the mental health of Chinese older adults.",
+ "Abstract": "Therefore, this study puts forward the following suggestions: first, to develop family care for older adults and pay attention to the positive role of intergenerational support in the mental comfort of older adults; second, it is imperative for the government and social service departments to assist older adults in establishing correct concepts of Internet use, enhancing their digital literacy, and improving their digital skills.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Female",
+ "Male",
+ "China",
+ "Mental Health",
+ "Internet Use",
+ "Middle Aged",
+ "Residence Characteristics",
+ "Aged, 80 and over",
+ "Independent Living",
+ "Surveys and Questionnaires",
+ "Internet",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39712299",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Neighborhood social environment and mental health of older adults in China: the mediating role of subjective well-being and the moderating role of green space.",
+ "Abstract": "This study enriches the empirical research on neighborhood social environment and mental health. First of all, older adults living in communities with good safety conditions and high social trust are less affected by negative emotions and tend to have good mental health. Second, deeper neighborhood ties, higher social trust, and safer community environments help older adults to be less disturbed by negative situations, have a positive effect on their SWB, and indirectly promote mental health. At the same time, green space can provide a place for older adults to socialize, enhance the positive impact of neighborhood ties on SWB, and further promote the mental health of older adults. Finally, this study suggests that the government and community managers pay attention to the construction of neighborhood social environment and green space, and provide support for \"healthy community\" and \"healthy aging\" planning.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Mental Health",
+ "Aged",
+ "Social Environment",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Residence Characteristics",
+ "Surveys and Questionnaires",
+ "Neighborhood Characteristics",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39711409",
+ "Title": "Aerospace medicine and human performance",
+ "ArticleTitle": "A Proposed Framework to Regulate Mental Health in Airline Pilots.",
+ "Abstract": "The current regulatory approach to U.S. airline pilot mental health may have unintended negative consequences including healthcare avoidance and screening imprecision. An alternative approach should aim to address these factors while maintaining safety. The authors summarize the following related to mental health in U.S. airline pilots: 1) current regulatory approach and limitations, 2) available regulatory tools within the Sparrow fundamentals, and 3) a proposed novel regulatory approach. The authors propose the simultaneous utilization of multiple models to minimize the negative consequences of healthcare avoidance and screening imprecision. The proposed framework aims to address current limitations. Hoffman WR, Suh A, Sprott T, Manderson K, Snyder Q, Sparrow M, Tvaryanas A. A proposed framework to regulate mental health in airline pilots. Aerosp Med Hum Perform. 2024; 95(12):940-943.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pilots",
+ "Aerospace Medicine",
+ "Mental Health",
+ "United States"
+ ]
+ },
+ {
+ "PMID": "39711341",
+ "Title": "Aerospace medicine and human performance",
+ "ArticleTitle": "Aerospace Medical Association Proposed Research Priorities for Mental Health and Safety in Aviation.",
+ "Abstract": "Research is needed to identify how to optimize and screen mental health across aviation SSP. This effort identified six key research priorities to achieve that aim. Hoffman WR, Tvaryanas A, Snyder Q, Spyropoulos BP, Garcia D, Schroeder D, Fahnenbruck G, Trottier K, Overbo S, Santilhano W, Brinks E, Ndoye A, Bongers H, O'Shaughnessy R, Miranda E; Aerospace Medical Association Mental Health Research Subgroup. Aerospace Medical Association proposed research priorities for mental health and safety in aviation. Aerosp Med Hum Perform. 2024; 95(11):845-850.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aerospace Medicine",
+ "Mental Health",
+ "Delphi Technique",
+ "Aviation",
+ "Research",
+ "Societies, Medical",
+ "Occupational Health"
+ ]
+ },
+ {
+ "PMID": "39711028",
+ "Title": "Epidemiology and psychiatric sciences",
+ "ArticleTitle": "Twelve-month follow-up of a controlled trial of a brief behavioural intervention to reduce psychological distress in young adolescent Syrian refugees.",
+ "Abstract": "Although EASE led to significant reductions in internalising problems, caregiver distress, and harsh disciplinary parenting at 3-months, these improvements were not maintained at 12 months relative to EUC. Scalable psychological interventions for young adolescents need to consider their ongoing mental health needs. Prospectively registered: ACTRN12619000341123.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Refugees",
+ "Syria",
+ "Psychological Distress",
+ "Female",
+ "Jordan",
+ "Male",
+ "Follow-Up Studies",
+ "Child",
+ "Single-Blind Method",
+ "Stress Disorders, Post-Traumatic",
+ "Depression",
+ "Stress, Psychological",
+ "Behavior Therapy",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39710807",
+ "Title": "International journal of mental health nursing",
+ "ArticleTitle": "The Relationship Between Resilience and Mental Health Status Among Nurses With Workplace Violence Experiences: A Cross-Sectional Study.",
+ "Abstract": "Nurses encounter many stressors and challenges at work, which can negatively affect their mental and physical health. Modern theories of resilience suggest that resilience is a dynamic process of positive adaptation to adversity. This process involves personal growth through adversity, developing effective coping strategies and inculcating the ability to cope with stress. The resilience process involves individual characteristics, social support and environmental factors, including workplace culture. Strengthening nurses' resilience can help them cope with adversity, maintain their mental health and well-being and support their provision of care. The aim of this study was to examine the associations between workplace characteristics, resilience and mental health status among nurses with experiences of workplace violence. The study objectives were to analyse the relationships between workplace characteristics, resilience and mental health status among nurses with experiences of workplace violence and to investigate the effects of resilience on nurses' mental health outcomes. In this cross-sectional study, full-time nurses at a medical centre in Taiwan completed a questionnaire survey. Of 600 distributed questionnaires, 334 nurses were identified to have experienced workplace violence. The questionnaires included items on workplace violence, resilience, metal health status (burnout and mental distress), sleep quality, work characteristics (job control, psychological job demands and workplace justice) and demographic characteristics. Data were analysed through chi-square tests and multivariate logistic regression. Nurses with low resilience tended to be younger, work more rotating/night shifts and perceive lower levels of job control and workplace justice. They also reported higher risks of burnout and mental distress and lower sleep quality. Multivariate logistic regression revealed that psychological job demands, workplace justice and resilience significantly influenced nurses' mental health status. Nurses with high resilience exhibited a lower risk of mental distress and higher sleep quality. However, resilience was not associated with burnout. The findings revealed how workplace factors and resilience influence nurses' mental health. The findings help nurse managers and policymakers develop strategies to promote nurses' resilience and mental health and mitigate the adverse effects of negative workplace events.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Resilience, Psychological",
+ "Cross-Sectional Studies",
+ "Female",
+ "Adult",
+ "Male",
+ "Workplace Violence",
+ "Burnout, Professional",
+ "Mental Health",
+ "Middle Aged",
+ "Surveys and Questionnaires",
+ "Nursing Staff, Hospital",
+ "Taiwan"
+ ]
+ },
+ {
+ "PMID": "39710755",
+ "Title": "Journal of health, population, and nutrition",
+ "ArticleTitle": "Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study.",
+ "Abstract": "We examined the socio-economic impact, quality of life, and psychological distress among patients affected by DR TB in Romania. The results of this study suggest that social and psychological support will ensure a better standard of living during and following TB treatment.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "Romania",
+ "Male",
+ "Female",
+ "Prospective Studies",
+ "Tuberculosis, Multidrug-Resistant",
+ "Middle Aged",
+ "Adult",
+ "Mental Health",
+ "Social Class",
+ "Socioeconomic Factors",
+ "Surveys and Questionnaires",
+ "Aged",
+ "Cohort Studies",
+ "Longitudinal Studies",
+ "Psychological Well-Being"
+ ]
+ },
+ {
+ "PMID": "39710684",
+ "Title": "BMC women's health",
+ "ArticleTitle": "Associations between mental health conditions in pregnancy and maternal socioeconomic status: a population-based retrospective cohort study in Ontario, Canada.",
+ "Abstract": "Despite a universal healthcare system, the variations in mental health prevalence and risk during pregnancy based on SES suggest health inequity in Ontario, Canada. Future studies are needed to examine the mechanisms of this health inequity to guide policy makers in reducing disparities in Ontario.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Ontario",
+ "Pregnancy",
+ "Retrospective Studies",
+ "Adult",
+ "Social Class",
+ "Pregnancy Complications",
+ "Anxiety",
+ "Depression",
+ "Young Adult",
+ "Residence Characteristics",
+ "Mental Health",
+ "Cohort Studies",
+ "Educational Status",
+ "Mental Disorders",
+ "Income"
+ ]
+ },
+ {
+ "PMID": "39710634",
+ "Title": "BMC women's health",
+ "ArticleTitle": "The pandemic within a pandemic: mental health and wellbeing of racially Minoritised women experiencing domestic abuse during the COVID-19 pandemic in the UK.",
+ "Abstract": "Implications such as incorporating culturally competent mental health support, exploring the complex and multiple underpinnings of mental health in racially Minoritised victim-survivors of domestic abuse for future pandemic preparedness and support provision are discussed.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Female",
+ "United Kingdom",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Mental Health",
+ "Domestic Violence",
+ "Middle Aged",
+ "Social Support",
+ "Resilience, Psychological",
+ "Pandemics",
+ "Young Adult",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39710627",
+ "Title": "International journal of mental health nursing",
+ "ArticleTitle": "The Effects of Universal Educational Interventions in Improving Mental Health Literacy, Depression, and Anxiety Among Adolescents: A Systematic Review and Meta-Analysis.",
+ "Abstract": "Adolescents are susceptible to developing depression and anxiety, and educational interventions could improve their mental well-being. This systematic review aimed to evaluate the effectiveness of universal educational prevention interventions in improving mental health literacy, depression, and anxiety among adolescents. Eight electronic databases were searched until June 2024: Cochrane Library, PubMed, EMBASE, CINAHL, PsycINFO, Scopus, Web of Science, ProQuest Dissertations, and Theses Global. Since the included studies assessed various aspects of mental health literacy, the results for mental health literacy were synthesized narratively. In contrast, a meta-analysis using a random-effects model was applied to the depression and anxiety outcomes. Heterogeneity was examined using I",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Health Literacy",
+ "Adolescent",
+ "Anxiety",
+ "Depression",
+ "Mental Health",
+ "Health Education"
+ ]
+ },
+ {
+ "PMID": "39710497",
+ "Title": "Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society",
+ "ArticleTitle": "Depression status and risk factors analysis based on the 'individual-social-health system' dimension: evidence from middle-aged and elderly people in China.",
+ "Abstract": "The mental health of the middle-aged and elderly population is poor and affected by multidimensional factors. The Chinese government should continue to strengthen its efforts to prevent and treat depression in the middle-aged and elderly population, and establish individualised and comprehensive strategies and measures to enhance the operational effectiveness of the policy.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "China",
+ "Aged",
+ "Risk Factors",
+ "Middle Aged",
+ "Depression",
+ "Longitudinal Studies",
+ "Health Status",
+ "Mental Health",
+ "Aged, 80 and over",
+ "Rural Population",
+ "Logistic Models"
+ ]
+ },
+ {
+ "PMID": "39710338",
+ "Title": "Contemporary clinical trials",
+ "ArticleTitle": "Optimization of a digital health intervention to enhance well-being among adolescent and young adult cancer survivors: Design and methods of the EMPOWER full factorial trial.",
+ "Abstract": "Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations and have not been routinely tested in AYA survivors. We are optimizing a web-based positive skills intervention for AYA cancer survivors called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) by: (1) determining which intervention components have the strongest effects on well-being and (2) identifying demographic and individual difference variables that mediate and moderate EMPOWER's efficacy. EMPOWER is a five-session online intervention that teaches behavioral and cognitive skills for increasing psychological well-being. Guided by the Multiphase Optimization Strategy (MOST), we assign two levels (yes, no) to each of five intervention components (positive events, capitalizing, & gratitude; mindfulness; positive reappraisal; personal strengths & goal-setting; acts of kindness), allowing us to evaluate the effects of individual and combined intervention components on positive affect in a full factorial design. Post-treatment AYA cancer survivors (N\u00a0=\u00a0352) are recruited from participating NCI-designated comprehensive cancer centers and randomized to one of 32 experimental conditions. Our primary outcome is positive affect; potential mediating and moderating variables include coping self-efficacy and emotional support, respectively. Upon trial completion, we will have an optimized, digital health intervention to enhance psychological well-being among AYA cancer survivors. EMPOWER will be scalable and primed for a large, multi-site trial among AYAs who would otherwise not have access to supportive care interventions to manage distress and enhance well-being.",
+ "Predictions": [
+ "Cancer",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Cancer Survivors",
+ "Adolescent",
+ "Young Adult",
+ "Female",
+ "Male",
+ "Internet-Based Intervention",
+ "Mindfulness",
+ "Adult",
+ "Emotional Regulation",
+ "Quality of Life",
+ "Mental Health",
+ "Depression",
+ "Neoplasms",
+ "Research Design",
+ "Adaptation, Psychological",
+ "Digital Health"
+ ]
+ },
+ {
+ "PMID": "39709458",
+ "Title": "Trials",
+ "ArticleTitle": "Implementation of a parent training intervention (SPARCK) to prevent childhood mental health problems: study protocol for a pragmatic implementation trial in Norwegian municipalities.",
+ "Abstract": "ClinicalTrials.gov NCT05800522.\u00a0Registered on 2023.03.23.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Child",
+ "Humans",
+ "Adaptation, Psychological",
+ "Child Behavior",
+ "Mental Disorders",
+ "Mental Health",
+ "Multicenter Studies as Topic",
+ "Norway",
+ "Parents",
+ "Pragmatic Clinical Trials as Topic"
+ ]
+ },
+ {
+ "PMID": "39709340",
+ "Title": "BMC medical research methodology",
+ "ArticleTitle": "The analysis and reporting of multiple outcomes in mental health trials: a methodological systematic review.",
+ "Abstract": "Our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 11th January 2023 (CRD42023382274).",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Randomized Controlled Trials as Topic",
+ "Mental Health",
+ "Research Design",
+ "Outcome Assessment, Health Care",
+ "Mental Disorders",
+ "Treatment Outcome"
+ ]
+ },
+ {
+ "PMID": "39709337",
+ "Title": "BMC anesthesiology",
+ "ArticleTitle": "Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.",
+ "Abstract": "Chinese Clinical Trial Registry (ChiCTR2400084940, date of registration: 05/28/2024).",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sufentanil",
+ "Male",
+ "Cough",
+ "Female",
+ "Ketamine",
+ "Middle Aged",
+ "Prospective Studies",
+ "Adult",
+ "Anesthesia, General",
+ "Anesthetics, Intravenous",
+ "Mental Health",
+ "Double-Blind Method"
+ ]
+ },
+ {
+ "PMID": "39709183",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Promoting Women's Mental Health Across the Life Course.",
+ "Abstract": "The guest editors for this series describe the importance of a life course perspective to women's mental health and introduce the articles in the issue.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Mental Health",
+ "Women's Health",
+ "Health Promotion"
+ ]
+ },
+ {
+ "PMID": "39709182",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Racial Categorization in Women's Mental Health Research Fails to Meet the Needs of Multiracial, Biracial, and Mixed-Race Women in the United States.",
+ "Abstract": "The author challenges women's mental health researchers to critically examine the categories of race available for research participants, surveillance data, and medical records.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "United States",
+ "Women's Health",
+ "Racial Groups",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39708948",
+ "Title": "Chemosphere",
+ "ArticleTitle": "Association between chronic ambient heavy metal exposure and mental health in Korean adult patients with asthma and the general population.",
+ "Abstract": "This study suggests that exposure to airborne metals significantly increases depressive symptoms and suicidal ideation, especially in individuals with asthma. Additional clinical research is needed to better understand these associations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Asthma",
+ "Metals, Heavy",
+ "Male",
+ "Adult",
+ "Female",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Republic of Korea",
+ "Mental Health",
+ "Suicidal Ideation",
+ "Environmental Exposure",
+ "Air Pollutants",
+ "Young Adult",
+ "Depression",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39707472",
+ "Title": "BMC psychology",
+ "ArticleTitle": "Insights into general practitioners' self-care across 38 countries during the pandemic: a cross-sectional study.",
+ "Abstract": "GPs have navigated the pandemic uniquely, and despite applying self-care practices they faced some level of impact, hence self-care interventions for healthcare professionals should be regarded as essential rather than optional. A long-term investment in strategies focused on improving GPs' self-care is necessary to increase resilience among GPs and ensure their optimal well-being levels are achieved.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "General Practitioners",
+ "Self Care",
+ "Cross-Sectional Studies",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Burnout, Professional",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "Anxiety",
+ "SARS-CoV-2",
+ "Pandemics"
+ ]
+ },
+ {
+ "PMID": "39706574",
+ "Title": "Journal of obstetric, gynecologic, and neonatal nursing : JOGNN",
+ "ArticleTitle": "Strategies to Improve Women's Mental Health Across the Life Course.",
+ "Abstract": "The authors describe four important strategies to improve women's mental health during the perinatal period and across the life course.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Mental Health",
+ "Women's Health",
+ "Pregnancy",
+ "Perinatal Care",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39706486",
+ "Title": "Preventive medicine",
+ "ArticleTitle": "Binge drinking and subsequent health and well-being among middle-aged Spanish adults: An outcome-wide analysis.",
+ "Abstract": "Our study provides novel insights into the complex and multifaceted relationship of binge drinking with health and well-being. Further research will enhance our understandings of binge drinking and inform culturally appropriate interventions that effectively mitigate its negative consequences.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Binge Drinking",
+ "Male",
+ "Middle Aged",
+ "Spain",
+ "Longitudinal Studies",
+ "Health Behavior",
+ "Mental Health",
+ "Health Status",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39706485",
+ "Title": "Journal of affective disorders",
+ "ArticleTitle": "Longitudinal analysis of lifetime stressors and depression: Exploring intersectionality and tailoring social support for better mental health in a community population cohort.",
+ "Abstract": "By applying an intersectional lens, the present study provides a novel quantitative instrument for documenting the associations of stress and depression in various social identities. The findings of the study suggest more focused intervention programs and strategies for risk reduction should focus on identified characteristics and pay particular attention to the combined effect of lifetime stressors and discovered social identities.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Social Support",
+ "Male",
+ "Female",
+ "Longitudinal Studies",
+ "Adult",
+ "Stress, Psychological",
+ "Middle Aged",
+ "Depressive Disorder, Major",
+ "Mental Health",
+ "Social Class",
+ "Socioeconomic Factors",
+ "Young Adult",
+ "Aged",
+ "Risk Factors",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39706484",
+ "Title": "Journal of affective disorders",
+ "ArticleTitle": "Mental health during the 2022 Russo-Ukrainian War: A scoping review and unmet needs.",
+ "Abstract": "Cohort studies across different phases of the RUW and populations are required to deliver effective clinical and public health interventions, especially to at-risk populations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mental Disorders",
+ "Mental Health",
+ "Ukraine",
+ "Armed Conflicts",
+ "Refugees"
+ ]
+ },
+ {
+ "PMID": "39705174",
+ "Title": "AIDS education and prevention : official publication of the International Society for AIDS Education",
+ "ArticleTitle": "Conceptualizations of Mental Health Among Young Black Gay, Bisexual, and Other Men (YB-GBMSM) Who Have Sex With Men Who Are Living With HIV.",
+ "Abstract": "Young Black gay, bisexual, and other men who have sex with men who are living with HIV are at an increased risk of experiencing poor mental health due to their exposures to intersectional stigma and discrimination, but often do not seek traditional mental health care. We qualitatively explored conceptualizations of mental health through interviews with 40 participants and analyzed our data using a phenomenology-informed approach. Participants conceptualized mental health as having inward-facing (cultivation of a healthy relationship with oneself, maintaining a peaceful state of mind, lack of depressed mood) and outward-facing components (goal-oriented behavior, resilient coping mechanisms). Some participants espoused an internal locus of control over one's mental state, while others focused on structural or environmental factors as key drivers of mental health. Our findings suggest that provider trainings and service integration, consistent with a more holistic conception of mental health, could help providers support well-being among this population.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Adult",
+ "Humans",
+ "Male",
+ "Young Adult",
+ "Adaptation, Psychological",
+ "Black or African American",
+ "HIV Infections",
+ "Interviews as Topic",
+ "Mental Health",
+ "Qualitative Research",
+ "Sexual and Gender Minorities",
+ "Social Stigma"
+ ]
+ },
+ {
+ "PMID": "39704003",
+ "Title": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
+ "ArticleTitle": "Beyond the boundaries: Transitioning from categorical to dimensional paradigms in mental health diagnostics.",
+ "Abstract": "Mental health diagnostics is undergoing a transformation, with a shift away from traditional categorical systems like the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and the International Classification of Diseases, 11th Revision (ICD-11), and toward innovative frameworks like the Hierarchical Taxonomy of Psychopathology (HiTOP) and the Research Domain Criteria (RDoC). These emerging models prioritize dimensional and biobehavioral approaches in order to overcome limitations such as oversimplification, comorbidity and heterogeneity. This editorial explores the challenges of implementing these paradigms, such as the need for empirical validation, interdisciplinary collaboration and clinician training. It highlights the importance of advanced tools, biomarkers and technological integration to improve precision in diagnosis and treatment. Future research directions include creating reliable dimensional assessment methods, conducting longitudinal studies and fostering interdisciplinary networks. By bridging traditional and emerging frameworks, the field can progress toward personalized, biologically informed mental health treatment. This transition necessitates collaboration among researchers, clinicians and policymakers to improve diagnostic accuracy and treatment outcomes for those affected by mental health disorders.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mental Disorders",
+ "Mental Health",
+ "Diagnostic and Statistical Manual of Mental Disorders",
+ "International Classification of Diseases"
+ ]
+ },
+ {
+ "PMID": "39703482",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Interventions aiming to improve menstrual, sexual, reproductive, and mental health among out-of-school girls: a systematic review.",
+ "Abstract": "This review suggests that programmes can improve OosG's SRMH knowledge, attitudes, and practices and can be delivered in low resource contexts. Effective interventions are needed to support OoSGs, including interventions focusing on SRMH support incorporating elements of cash-transfer, and comprehensive sexual education, and to aid local policy and programming.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Adolescent",
+ "Mental Health",
+ "Reproductive Health",
+ "Sexual Behavior",
+ "Sexual Health",
+ "Menstruation",
+ "Health Knowledge, Attitudes, Practice"
+ ]
+ },
+ {
+ "PMID": "39703180",
+ "Title": "Primary health care research & development",
+ "ArticleTitle": "Community pharmacist involvement in social prescribing for mental health: a qualitative study.",
+ "Abstract": "An inductive iterative approach to thematic analysis produced four superordinate themes: (1) offering choice a non-pharmacological option, (2) supporting pharmacy communities - 'it is an extension of what we do', (3) stakeholder perspectives - pharmacists are very busy and their expertise unknown by some, and (4) potential for pharmacy in primary care.Stakeholders viewed CP as local to and accessible by their community. Pharmacists perceived referral to SP services as part of their current role. General practitioner participants considered pharmacy involvement could reduce their workload and expand the primary healthcare team. Importantly, general practitioners and CP viewed SP as a non-pharmacological alternative to prescribing unnecessary antidepressants and reduce associated adverse effects. All participants voiced concerns about pharmacy dispensing busyness as a potential barrier to involvement and pharmacists requesting mental health training updates.Key findings suggest CP offer a potential alternative to the general practitioner for people with mild to moderate depression and anxiety seeking access to support and health information. However, CP need appropriately commissioned and funded involvement in SP, including backfill for ongoing dispensing, medicines optimization, and mental health first aid training.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Qualitative Research",
+ "Male",
+ "Female",
+ "Pharmacists",
+ "Adult",
+ "England",
+ "Middle Aged",
+ "Focus Groups",
+ "Mental Health",
+ "Community Pharmacy Services",
+ "Depression",
+ "Interviews as Topic",
+ "Professional Role",
+ "Anxiety"
+ ]
+ },
+ {
+ "PMID": "39702091",
+ "Title": "BMC primary care",
+ "ArticleTitle": "Addressing \"what matters most\" to reduce mental health stigma in primary healthcare settings: a qualitative study in Lebanon.",
+ "Abstract": "This study identified key domains to understand the factors for WMM in reducing mental health stigma in Lebanon and explored factors that shape the values and priorities of both PWLE and primary healthcare providers.\u00a0The study suggests assessing the effectiveness of anti-stigma interventions that actively engage PWLE in their design and implementation, while exploring the broader applicability of the WMM framework across different cultural and healthcare settings.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Lebanon",
+ "Primary Health Care",
+ "Social Stigma",
+ "Qualitative Research",
+ "Mental Disorders",
+ "Male",
+ "Female",
+ "Attitude of Health Personnel",
+ "Health Personnel",
+ "Adult",
+ "Interviews as Topic",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39701588",
+ "Title": "JMIR research protocols",
+ "ArticleTitle": "A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study.",
+ "Abstract": "DERR1-10.2196/59372.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "COVID-19",
+ "Mental Health",
+ "Female",
+ "Male",
+ "Mental Health Services",
+ "United States",
+ "Child",
+ "Emotions",
+ "Telemedicine",
+ "Social Skills",
+ "School Mental Health Services"
+ ]
+ },
+ {
+ "PMID": "39700572",
+ "Title": "Social science & medicine (1982)",
+ "ArticleTitle": "Training humans to supplement a machine learning system: The role of guides in a digital mental health intervention.",
+ "Abstract": "Machine learning (ML) is increasingly prevalent in mental health care, with contemporary initiatives leveraging these technologies, sometimes in combination with wearable devices, toward novel interventions. This paper investigates the development of one of these systems, using conversation analysis approach to better understand the work of \"guides,\" a form of labor that is involved in the trial's implementation, and how people are trained for this role. Guides are assigned participants with whom they meet one-on-one over the course of the behavioral modification intervention. Guides are described in advance as an easily replaceable component of the trial. While their work appears sophisticated and valuable in ethnographic observation, in training sessions it is described and enacted as a narrow communicative task of adequately resolving participant queries, even when these queries raise questions about environmental factors or the trial protocol. This paper demonstrates how this occurs in guidance training interactions, offering an empirical account of how new forms of human labor that are required by a machine learning driven intervention are constituted in the interactional practice of training-a process that contributes to both the minimization of the new human labor required for ML-based interventions and the conceptualization of digital mental health interventions as neutral, portable, and not contingent on environmental factors. As digital mental health initiatives move from small pilot studies into broader implementation, understanding of the interactional processes by which new human roles are established is key for specifying new kinds of human labor involved in digital health interventions and leveraging these new roles for adapting interventions according to the particular circumstances of diverse participants and patients.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Machine Learning",
+ "Mental Health",
+ "Adult",
+ "Female"
+ ]
+ },
+ {
+ "PMID": "39700155",
+ "Title": "PloS one",
+ "ArticleTitle": "Exploring the gender gap in young adult mental health during COVID-19: Evidence from the UK.",
+ "Abstract": "Although across all ages and genders, mental health had returned to near pre-pandemic levels by September 2021, young people and especially women continue to have worse mental health compared to other age groups, which is consistent with pre-COVID age and gender inequalities. Loneliness is a key driver in gendered mental health inequalities during the pandemic in a young adult population.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Female",
+ "Male",
+ "Mental Health",
+ "United Kingdom",
+ "Adolescent",
+ "Young Adult",
+ "Loneliness",
+ "Adult",
+ "Sex Factors",
+ "Pandemics",
+ "SARS-CoV-2",
+ "Longitudinal Studies",
+ "Aged",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39699982",
+ "Title": "Annali dell'Istituto superiore di sanita",
+ "ArticleTitle": "Pandemic impact on training and mental health of medical residents: an Italian multicentre prospective study.",
+ "Abstract": "Residents reported a relevant frequency of mental issues. Many work-related changes were associated with poor mental health.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Italy",
+ "Prospective Studies",
+ "COVID-19",
+ "Internship and Residency",
+ "Male",
+ "Female",
+ "Adult",
+ "Depression",
+ "Anxiety",
+ "Mental Health",
+ "Stress Disorders, Post-Traumatic",
+ "Pandemics"
+ ]
+ },
+ {
+ "PMID": "39699544",
+ "Title": "Revista da Sociedade Brasileira de Medicina Tropical",
+ "ArticleTitle": "Chikungunya chronic arthralgia: impact on general and mental health and absenteeism from work.",
+ "Abstract": "Chikungunya chronic arthralgia impacts long-term health and work.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Absenteeism",
+ "Male",
+ "Female",
+ "Chikungunya Fever",
+ "Arthralgia",
+ "Middle Aged",
+ "Adult",
+ "Chronic Disease",
+ "Mental Health",
+ "Cross-Sectional Studies",
+ "Depression",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39699441",
+ "Title": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil",
+ "ArticleTitle": "Exploring the complexities and challenges of healthcare access for transgender people in Minas Gerais state: a qualitative study a decade following the implementation of the transsexualization process in the Brazilian National Health System.",
+ "Abstract": "Expansion of specialized services and the role of PHC for this population, in order to improve access and care for the transgender population via the Brazilian National Health System in Minas Gerais state.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Brazil",
+ "Transgender Persons",
+ "Health Services Accessibility",
+ "Male",
+ "Female",
+ "Primary Health Care",
+ "National Health Programs",
+ "Interviews as Topic",
+ "Health Personnel",
+ "Health Services for Transgender Persons",
+ "Qualitative Research",
+ "Adult",
+ "Health Policy",
+ "Mental Health",
+ "Transsexualism",
+ "Young Adult",
+ "Middle Aged"
+ ]
+ },
+ {
+ "PMID": "39699366",
+ "Title": "Revista brasileira de enfermagem",
+ "ArticleTitle": "Recommendations for guidelines for promoting mental health in the workplace: an umbrella review.",
+ "Abstract": "the interventions are based on prevention, promotion and early recognition, support and rehabilitation of mental health problems.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Workplace",
+ "Mental Health",
+ "Health Promotion",
+ "Occupational Health",
+ "Guidelines as Topic"
+ ]
+ },
+ {
+ "PMID": "39697298",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Recovery trajectories of mental health symptoms among Chinese adolescents following the end of COVID-19.",
+ "Abstract": "This study is one of the first to reveal the post-pandemic mental health recovery trajectories of Chinese adolescents, highlighting the importance of considering both the number and severity of cumulative mental health problems. The findings offer valuable insights into suicide prevention and the development of targeted interventions to support youth mental health recovery.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Adolescent",
+ "Female",
+ "Humans",
+ "Male",
+ "China",
+ "COVID-19",
+ "East Asian People",
+ "Mental Disorders",
+ "Mental Health",
+ "Risk Factors",
+ "Students",
+ "Suicidal Ideation",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39697006",
+ "Title": "Health promotion international",
+ "ArticleTitle": "The influence of access to care on the health literacy of families in Mexico.",
+ "Abstract": "Health literacy (HL) is essential to understanding health information and achieving health goals. Unfortunately, limited information is available on how parent HL impact child health outcomes. This is critical to understand in areas of the world where access to healthcare services is limited or unavailable. Thus, the purpose of this study was to assess the moderating influence of access to care on the relationship between parent HL and child health outcomes in Mexico. Using a geographically stratified convenience sample survey design, we gathered a sample of 373 parent-child dyads throughout Mexico in August of 2021. Using the HLS-Q12, the Warwick-Edinburgh Mental Wellbeing Scale, healthcare access questions developed by Levy and Janke, a single-item self-report overall health measure, and questions about substance use frequency, we found that parent HL was positively associated with youth mental wellbeing and overall health. Limited healthcare access was associated with increased youth cigarette, marijuana and alcohol use. Our results indicate that efforts to increase parent HL may be effective in improving youth health behaviors and outcomes.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Health Services Accessibility",
+ "Health Literacy",
+ "Mexico",
+ "Female",
+ "Male",
+ "Adolescent",
+ "Child",
+ "Adult",
+ "Surveys and Questionnaires",
+ "Parents",
+ "Mental Health",
+ "Middle Aged",
+ "Health Behavior"
+ ]
+ },
+ {
+ "PMID": "39696336",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Building a research agenda on preventing and addressing sexual assault and intimate partner violence against trans people: a two-stage priority-setting exercise.",
+ "Abstract": "These questions form Canada's first research agenda on SA/IPV against trans people. Together, they reflect the insights of stakeholder groups who have been historically excluded from research priority-setting processes and will guide future and much-needed work on the topic. Actionable information on preventing and addressing SA/IPV against trans persons will help reduce negative outcomes associated with being victimized.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Intimate Partner Violence",
+ "Female",
+ "Sex Offenses",
+ "Canada",
+ "Male",
+ "Transgender Persons",
+ "Surveys and Questionnaires",
+ "Crime Victims",
+ "Research",
+ "Stakeholder Participation",
+ "Mental Health",
+ "Health Priorities"
+ ]
+ },
+ {
+ "PMID": "39696264",
+ "Title": "BMC public health",
+ "ArticleTitle": "Unlocking the door to mental wellness: exploring the impact of homeownership on mental health issues.",
+ "Abstract": "This study provides robust evidence supporting the positive impact of homeownership on mental health. Promoting affordable homeownership opportunities has the potential to alleviate the mental health burden in the United States.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Adolescent",
+ "Young Adult",
+ "Ownership",
+ "Housing",
+ "Behavioral Risk Factor Surveillance System",
+ "Aged",
+ "United States",
+ "Mental Health",
+ "Prevalence",
+ "Depressive Disorder"
+ ]
+ },
+ {
+ "PMID": "39696245",
+ "Title": "BMC public health",
+ "ArticleTitle": "Assessment of displaced Sudanese school-age children's mental health at Ad-Damar, River Nile, Sudan, 2024: a descriptive cross-sectional study.",
+ "Abstract": "The study highlights the urgent need for better mental health support for displaced children, given the high prevalence of mental health issues and inadequate support from schools and families. Future research should include longitudinal studies to evaluate long-term effects and intervention effectiveness. Key steps include improving access to mental health services, fostering supportive educational environments, and enhancing family support systems.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sudan",
+ "Cross-Sectional Studies",
+ "Child",
+ "Female",
+ "Adolescent",
+ "Male",
+ "Refugees",
+ "Mental Health",
+ "Surveys and Questionnaires",
+ "Stress Disorders, Post-Traumatic"
+ ]
+ },
+ {
+ "PMID": "39696093",
+ "Title": "BMC public health",
+ "ArticleTitle": "Characterising the activity, lifestyle behaviours and health outcomes of UK university students: an observational cohort study with a focus on gender and ethnicity.",
+ "Abstract": "The findings of the current study provide an update on the landscape of UK university students' health and health-related behaviours. Overall, health-related outcomes and behaviours are poor in this population and these data suggest that gender and ethnicity play a role in determining students' health and health-related behaviours. Therefore, these factors should be considered when developing strategies to promote healthy living in the context of higher education.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Students",
+ "Universities",
+ "United Kingdom",
+ "Young Adult",
+ "Exercise",
+ "Cohort Studies",
+ "Life Style",
+ "Ethnicity",
+ "COVID-19",
+ "Health Behavior",
+ "Sex Factors",
+ "Adult",
+ "Adolescent",
+ "Body Mass Index",
+ "Diet",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39695709",
+ "Title": "Trials",
+ "ArticleTitle": "Strategies to improve recruitment in mental health clinical trials: a scoping review (RE-MIND study).",
+ "Abstract": "The key finding was that consideration should be given to a mixed methods approach to recruitment not only to enable wider and more diverse participation in mental health trials but also to realize greater efficiency.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Patient Selection",
+ "Mental Disorders",
+ "Mental Health",
+ "Randomized Controlled Trials as Topic"
+ ]
+ },
+ {
+ "PMID": "39695633",
+ "Title": "BMC medicine",
+ "ArticleTitle": "Relationships between neurodivergence status and adverse childhood experiences, and impacts on health, wellbeing, and criminal justice outcomes: findings from a regional household survey study in England.",
+ "Abstract": "The combination of being ND and experiencing ACEs could additively increase risks of experiencing poor wellbeing and criminal justice outcomes by a greater extent than expected. Preventing and responding to ACEs in ND populations should be a priority to reduce risks of poor health, wellbeing, and criminal justice outcomes in this population.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Adverse Childhood Experiences",
+ "Female",
+ "England",
+ "Adult",
+ "Middle Aged",
+ "Adolescent",
+ "Young Adult",
+ "Criminal Law",
+ "Health Status",
+ "Surveys and Questionnaires",
+ "Aged",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39695572",
+ "Title": "BMC public health",
+ "ArticleTitle": "Effects of active video games on mental health among college students: a systematic review.",
+ "Abstract": "https://www.crd.york.ac.uk/prospero , identifier: CRD42024510488.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Students",
+ "Video Games",
+ "Universities",
+ "Mental Health",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39695547",
+ "Title": "BMC public health",
+ "ArticleTitle": "The mental health of Chinese military personnel: a cross-sectional epidemiological study.",
+ "Abstract": "The prevalence of mental health problems among Chinese military personnel has remained at a relatively low level, but our data still suggest that a significant number of individuals in the Chinese military population are affected by mental health issues. It is crucial for military units, society, and the nation to continuously prioritize the mental well-being of soldiers and provide them with more mental health care services.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Military Personnel",
+ "Female",
+ "Male",
+ "Cross-Sectional Studies",
+ "China",
+ "Adult",
+ "Stress Disorders, Post-Traumatic",
+ "COVID-19",
+ "Sleep Initiation and Maintenance Disorders",
+ "Prevalence",
+ "Young Adult",
+ "Depression",
+ "Anxiety",
+ "Mental Health",
+ "Middle Aged",
+ "Surveys and Questionnaires",
+ "Adolescent",
+ "East Asian People"
+ ]
+ },
+ {
+ "PMID": "39695533",
+ "Title": "BMC public health",
+ "ArticleTitle": "The importance of including a mental health dimension in a multimorbidity indicator: an analysis of Belgian health survey data.",
+ "Abstract": "MIs that only take physical conditions into account underestimate their impact on individuals' lives. Including mental ill-health in an MI is key to linking it to health correlates.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Belgium",
+ "Male",
+ "Female",
+ "Multimorbidity",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Health Surveys",
+ "Mental Disorders",
+ "Quality of Life",
+ "Young Adult",
+ "Mental Health",
+ "Adolescent",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39695518",
+ "Title": "BMC public health",
+ "ArticleTitle": "Relationships between resilience, perceived social support, and mental health in military personnel: a cross-lagged analysis.",
+ "Abstract": "The negative and positive dimensions of military mental health can interact with each other. Moreover, enhancing resilience and perceived social support may be a novel perspective for improving the mental health of military personnel.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Resilience, Psychological",
+ "Military Personnel",
+ "Male",
+ "Social Support",
+ "Adult",
+ "Personal Satisfaction",
+ "Female",
+ "Mental Health",
+ "Depression",
+ "Longitudinal Studies",
+ "Young Adult",
+ "Surveys and Questionnaires",
+ "Cross-Sectional Studies"
+ ]
+ },
+ {
+ "PMID": "39695503",
+ "Title": "BMC public health",
+ "ArticleTitle": "The relationship between non-communicable disease risk and mental wellbeing in adolescence: a cross-sectional study utilising objective measures in Indonesia.",
+ "Abstract": "Our analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Indonesia",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Cross-Sectional Studies",
+ "Risk Factors",
+ "Mental Health",
+ "Quality of Life",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39695274",
+ "Title": "Scientific reports",
+ "ArticleTitle": "Media dependency, platform-swinging, and psychological depression among young college students in the polymedia environment.",
+ "Abstract": "As a comprehensive and affordable environment, polymedia lays the groundwork for exploring platform-swinging and offers a theoretical framework for investigating its dynamics. Platform-swinging and its unique niche characteristics provide a novel lens to examine the interplay between media dependency and psychological well-being. Using a survey questionnaire, this study collected data from 1210 university students in the Yangtze River Delta, China's most economically developed region, to examine the relationship between media dependency, platform-swinging, and psychological depression. Our findings suggest that the affordances of platform-swinging influence media dependency, whereas the nature of media dependency shapes psychological depression. This study contributes to a deeper understanding of how young adults navigate various media platforms and sheds light on the complex interrelations between media use and mental health. Focusing on platform-swinging in the environment of polymedia explores the relationship between media dependency, platform-swinging, and psychological depression. Moreover, it also compensates for the one-sided understanding caused by simply examining media dependency and psychological depression. This study has practical value and theoretical significance for the psychological health of college students and the research and development of the media dependency theory.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Students",
+ "Female",
+ "Male",
+ "Young Adult",
+ "Depression",
+ "Universities",
+ "China",
+ "Surveys and Questionnaires",
+ "Mental Health",
+ "Adolescent",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39693620",
+ "Title": "Journal of medical Internet research",
+ "ArticleTitle": "When and Why Adults Abandon Lifestyle Behavior and Mental Health Mobile Apps: Scoping Review.",
+ "Abstract": "This study highlights the complex nature of health app abandonment and the need for an improved understanding of user engagement over time, underscoring the importance of addressing various factors contributing to abandonment, from technical issues to evolving user needs. Our findings also emphasize the need for longitudinal studies and a consistent definition of app abandonment to better understand and mitigate this phenomenon, thereby enhancing the effectiveness of health apps in supporting public health initiatives.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mobile Applications",
+ "Adult",
+ "Mental Health",
+ "Health Behavior",
+ "Life Style",
+ "Exercise",
+ "Telemedicine"
+ ]
+ },
+ {
+ "PMID": "39693599",
+ "Title": "The Journal of nervous and mental disease",
+ "ArticleTitle": "Well-Being and Mental Health: Where Do We Stand After COVID-19 Pandemic?",
+ "Abstract": "Mental health encompasses the ability to cope with important stresses of life and to realize one's abilities in the community, and the COVID-19 pandemic represented a very stressful event for people with mental illnesses. Our aim was to assess mental well-being in people living with different mental disorders, comparing results obtained in 2016 with those observed after the COVID-19 pandemic. Ninety-six participants were assessed using the Mental Health Continuum Short Form and classified as \"flourishing,\" \"moderately mentally healthy,\" and \"languishing.\" Overall, a significant increase in the prevalence of \"flourishing\" and \"moderately mentally healthy\" subjects and a reduction of \"languishing\" subjects ( p = 0.003) were observed. However, a significant improvement in well-being ( p = 0.005) was observed only in the schizophrenia spectrum disorder group. Moreover, only subjects that never contracted SARS-CoV-2 showed a significant ( p = 0.019) increase in positive well-being states. Lockdowns may have led caregivers to spend more time with the participants, also increasing treatment adherence, resulting in an improvement of overall well-being in several participants.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Mental Health",
+ "Mental Disorders",
+ "Aged",
+ "Schizophrenia",
+ "SARS-CoV-2"
+ ]
+ },
+ {
+ "PMID": "39691047",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Beyond Traditional Practices: Innovating Workplace Mental Health in the Community.",
+ "Abstract": "Workplace mental health is a critical concern. Forty per cent of healthcare workers experience burnout, half intend to leave the profession and only 60% express satisfaction with the quality of care they provide. These statistics highlight the urgency for innovative and holistic approaches to support well-being within healthcare organizations. This article focuses on an organization that prioritizes the mental health of its 8,000 distributed staff. Guided by the values of love, life care and work with purpose, the organization implemented strategies to strengthen its culture, develop leadership and create supportive environments. Emphasis was placed on interventions to mitigate stress and fatigue. Successes and lessons learned are shared, offering a blueprint for other organizations.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Workplace",
+ "Burnout, Professional",
+ "Mental Health",
+ "Organizational Culture",
+ "Leadership",
+ "Health Personnel",
+ "Job Satisfaction",
+ "Ontario"
+ ]
+ },
+ {
+ "PMID": "39691046",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Promoting Psychological Health and Safety in Canadian Healthcare Organizations.",
+ "Abstract": "This article analyzes findings from the Health Standards Organization's new Global Workforce Survey (GWS). The GWS enables healthcare organizations to measure, analyze and benchmark their workforce's perceptions of working conditions, safety culture and care quality against peers. The GWS measures key features of The National Standard of Canada for Psychological Health and Safety in the Workplace (CSA Group and Bureau de normalisation du Qu\u00e9bec 2013; MHCC 2013). The article highlights how psychological health and safety in Canadian healthcare organizations can enhance the well-being of workers, improve patient care and ultimately contribute to a more effective healthcare system.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Canada",
+ "Mental Health",
+ "Occupational Health",
+ "Workplace",
+ "Health Personnel",
+ "Organizational Culture",
+ "Surveys and Questionnaires",
+ "Patient Safety",
+ "Safety Management"
+ ]
+ },
+ {
+ "PMID": "39691045",
+ "Title": "Healthcare quarterly (Toronto, Ont.)",
+ "ArticleTitle": "Introduction to Mental Health in Healthcare Workplaces.",
+ "Abstract": "In the quest by health leaders to create the conditions necessary for the delivery of safe, high-quality care, this issue of ",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Workplace",
+ "Health Personnel",
+ "Mental Health",
+ "Occupational Health"
+ ]
+ },
+ {
+ "PMID": "39690437",
+ "Title": "Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals",
+ "ArticleTitle": "Associations Between Food Security, Housing and Health in South Australia.",
+ "Abstract": "Food security is itself a determinant of health. Regular monitoring of the\u00a0prevalence of household food insecurity and addressing the structural factors influencing food affordability and availability are required. Further research on its links to health outcomes is warranted. SO WHAT?: Evidence-based action to address food insecurity will become more pressing as the crises of cost-of-living, housing, health system pressures and environmental disasters converge.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "South Australia",
+ "Housing",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Food Security",
+ "Health Status",
+ "Mental Health",
+ "Health Surveys",
+ "Socioeconomic Factors",
+ "Adolescent",
+ "Food Insecurity",
+ "Aged",
+ "Chronic Disease",
+ "Young Adult",
+ "Food Supply"
+ ]
+ },
+ {
+ "PMID": "39690123",
+ "Title": "Journal of child psychology and psychiatry, and allied disciplines",
+ "ArticleTitle": "Editorial: From adolescence into young adulthood - the importance of a longitudinal perspective across development in child and adolescent mental health.",
+ "Abstract": "The transition from adolescence into adulthood is a pivotal phase in a person's life, marking a period of significant social, psychological, and biological changes that can profoundly impact an individual's well-being and developmental trajectory. During this period, adolescents and young adults face increasing environmental demands from academic or occupational responsibilities and social interactions, including the pursuit of romantic partners. These changes are inherently related to stress, which is essential for adolescents and young adults to develop their personality and form an identity. Throughout adolescence into young adulthood, the brain undergoes maturational changes as part of the normal development, and it is possible that deviations from the expected developmental trajectories may contribute to the onset of psychiatric disorders in this age group. This editorial highlights recent work published in the Journal of Child Psychology and Psychiatry that examines important aspects of this developmental period.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Adolescent Development",
+ "Young Adult",
+ "Adult",
+ "Child",
+ "Mental Health"
+ ]
+ },
+ {
+ "PMID": "39690113",
+ "Title": "Salud colectiva",
+ "ArticleTitle": "[Racism and mental health in indigenous youth living in the Metropolitan Area of Oaxaca, Mexico].",
+ "Abstract": "Indigenous populations show high prevalence rates of mental disorders and limited access to mental health services. The aim of this study was to analyze the mental health care trajectories of indigenous youth living in the Metropolitan Area of Oaxaca, Mexico. Between May and August 2023, we conducted a qualitative study involving non-participant observation, in-depth interviews with seven indigenous youth, and semi-structured interviews with nine health professionals, healers, or leaders of mutual support groups. We identified processes, not exempt of tensions, in how these young people perceive themselves as both young and indigenous, in the development of their mental disorders, and in the ways they seek treatment. Their care involved the use of psychological and psychiatric services, mutual support groups, and, to a limited extent, traditional medicine. This study concludes that these dynamics are interwoven and amplified by interpersonal, institutional and epistemic racism, which must be dismantled to improve the mental health of indigenous youth.",
+ "Predictions": [
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mexico",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Racism",
+ "Mental Disorders",
+ "Qualitative Research",
+ "Mental Health",
+ "Mental Health Services",
+ "Young Adult",
+ "Interviews as Topic",
+ "Health Services Accessibility",
+ "Urban Population",
+ "Urban Health",
+ "Indigenous Peoples",
+ "Patient Acceptance of Health Care"
+ ]
+ }
+]
\ No newline at end of file
diff --git a/model/dataset/noncommunicable_diseases.json b/model/dataset/noncommunicable_diseases.json
new file mode 100644
index 0000000000000000000000000000000000000000..a339352e04955e733cb3897a89909b2f58ec6ea7
--- /dev/null
+++ b/model/dataset/noncommunicable_diseases.json
@@ -0,0 +1,2254 @@
+[
+ {
+ "PMID": "39737510",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "Prevalence of risk factors of non-communicable diseases among adults in urban slums of Burdwan municipality, West Bengal: A cross sectional study.",
+ "Abstract": "Background & objectives Non communicable diseases (NCD) have emerged as one of the leading causes of mortality and morbidity in India in the past few decades. This study was undertaken to determine the prevalence of NCD risk factors among adults residing in urban slums of West Bengal, India. Methods A community based cross-sectional study was conducted among adult population aged 15-69 yr in urban slums of Purba Burdwan district, West Bengal over a period of two months. A total of with 180 study participants selected by simple random sampling. Data were collected using a semi-structured schedule, adopted from the WHO STEPS questionnaire. Analysis was done using Chi-square test and logistic analysis. P<0.05 was considered to be significant. Results The prevalence of alcohol intake, smoking, inadequate vegetable and fruit intake, reduced physical activity and overweight and/or obesity was 27.8, 15.6 , 93.3 , 32.8 and 15.5 per cent, respectively among the study population. A significant association of smoking was found among males [Adjusted odds ratio (AOR) 2.54 Confidence interval (CI):1.76-6.99], those living in joint families (AOR 1.24 CI:1.17-1.34) and without any formal education (AOR 3.22 CI:1.50-13.87). The odds of alcohol consumption alcohol, were higher among those aged >44 yr (AOR 1.98 CI:1.34-7.22), males (AOR 2.65 CI:1.89-8.76), those who had no formal education (AOR 1.43 CI:1.23-2.77) and those who were employed (AOR 1.34 CI:1.02-4.09). Again respondents aged 45-69 yr (AOR 4.45 CI:1.79-10.99) and married (AOR 3.77 CI:1.76-7.44) were associated with overweight and or/obesity. Furthermore, age AOR 5.04 CI:1.34-17.98) and employment status (AOR 1.78 CI:1.67-3.09) were significantly associated with raised blood pressure in multivariate analysis. Interpretation & conclusions The high prevalence of risk factors of NCD in the study population is suggestive of a need for health promotion by creating awareness about the dangers of smoking and alcohol consumption as well as educating the people about the benefits of physical activity and eating a healthy diet.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adult",
+ "Middle Aged",
+ "India",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Aged",
+ "Poverty Areas",
+ "Adolescent",
+ "Prevalence",
+ "Smoking",
+ "Alcohol Drinking",
+ "Obesity",
+ "Cross-Sectional Studies",
+ "Young Adult",
+ "Urban Population"
+ ]
+ },
+ {
+ "PMID": "39737504",
+ "Title": "The Indian journal of medical research",
+ "ArticleTitle": "Stem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.",
+ "Abstract": "Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy. Results Of the 9206 studies screened, 61 studies that were relevant to stem cell use for non-malignant diseases were included for analysis. Autologous stem cells (75%) were used predominantly compared to allogenic stem cells (18.33%), followed by mixed type (6.67%). Use of bone marrow-derived stem cells (51%) was dominant, followed by melanocytes (19%), adipose (7%), haematopoietic (12%), and (11%) other types of stem cells. The study revealed 37 randomized clinical trial studies conducted in the government research hospital compared to the non-government. Interpretation & conclusions Maintaining the gold standard for stem cell therapy requires randomized clinical trials with large sample sizes, control groups, failures, adverse effects, etc. It is important to have a monitoring and regulation system in stem cell clinical research activities with enough preclinical data and repeated exchanges between the bench and the bedside.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Stem Cell Transplantation",
+ "Cell- and Tissue-Based Therapy",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39736607",
+ "Title": "International journal for equity in health",
+ "ArticleTitle": "Social and economic impacts of non-communicable diseases by gender and its correlates: a literature review.",
+ "Abstract": "NCDs pose a significant social and economic burden due to their impact on the health of the population, healthcare systems, and the economies of households and nations, which will likely increase over time. This impact is closely related to gender, although it has been scarcely documented. Public policies aimed at enhancing access and achieving UHC are essential to guarantee effective financial protection in health, especially for the most vulnerable sectors of the population.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Sex Factors",
+ "Employment",
+ "Socioeconomic Factors",
+ "Poverty",
+ "Universal Health Insurance",
+ "Cost of Illness"
+ ]
+ },
+ {
+ "PMID": "39732655",
+ "Title": "BMC public health",
+ "ArticleTitle": "Bias in machine learning applications to address non-communicable diseases at a population-level: a scoping review.",
+ "Abstract": "This review examines current applications of ML in NCDs, highlighting potential biases and strategies for mitigation. Future research should focus on communicable diseases and the transferability of ML models in low and middle-income settings. Our findings can guide the development of guidelines for the equitable use of ML to improve population health outcomes.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Machine Learning",
+ "Bias",
+ "Population Health",
+ "Algorithms"
+ ]
+ },
+ {
+ "PMID": "39731009",
+ "Title": "BMC public health",
+ "ArticleTitle": "Investigating the influence of working status changes on physical activity and non-communicable diseases in Korean middle-aged and older adults: insights from a longitudinal panel study.",
+ "Abstract": "This longitudinal study revealed that individuals engaged in or transitioning to employment displayed a reduced likelihood of regular PA. Moreover, those with work history, transitioning, or consistently working, exhibited increased vulnerability to all NCDs compared to those without work experience.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Republic of Korea",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Longitudinal Studies",
+ "Noncommunicable Diseases",
+ "Exercise",
+ "Employment",
+ "Aged",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39725416",
+ "Title": "BMJ open",
+ "ArticleTitle": "How does the level of functional impairment vary in individuals with non-communicable disease and comorbidity? Cross-sectional analysis of linked census and administrative data in Aotearoa New Zealand.",
+ "Abstract": "Functional impairment was strongly patterned by NCD type. NCD prevention efforts and disability supports are needed to reduce the burden of disability experienced.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "New Zealand",
+ "Cross-Sectional Studies",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Noncommunicable Diseases",
+ "Adult",
+ "Comorbidity",
+ "Censuses",
+ "Adolescent",
+ "Young Adult",
+ "Aged, 80 and over",
+ "Prevalence",
+ "Child",
+ "Child, Preschool"
+ ]
+ },
+ {
+ "PMID": "39722627",
+ "Title": "Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit",
+ "ArticleTitle": "The impact of health taxes on consumption of tobacco and sugar-sweetened beverages in the Eastern Mediterranean Region.",
+ "Abstract": "Consumption of tobacco, nicotine and sugar-sweetened beverages (SSBs) poses a significant risk to public health, contributing to increases in noncommunicable diseases (NCDs) such as cardiovascular disease, diabetes, cancer, and obesity. Globally, regular consumption of SSBs increases the risk of type 2 diabetes by 26%, and deaths related to tobacco and nicotine consumption exceed 8 million annually, including 1.3 million due to exposure to second-hand smoke. This loss of lives and the negative impact on health underscore the urgent need for effective public health interventions to curb the consumption of these harmful products.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sugar-Sweetened Beverages",
+ "Taxes",
+ "Tobacco Products",
+ "Mediterranean Region",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39709790",
+ "Title": "Redox biology",
+ "ArticleTitle": "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.",
+ "Abstract": "Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE). The products of these genes participate in numerous functions including biotransformation and redox homeostasis, lipid and iron metabolism, inflammation, proteostasis, as well as mitochondrial dynamics and energetics. Thus, it is possible that a single pharmacological NRF2 modulator might mitigate the effect of the main hallmarks of NCDs, including oxidative, proteostatic, inflammatory and/or metabolic stress. Research on model organisms has provided tremendous knowledge of the molecular mechanisms by which NRF2 affects NCDs pathogenesis. This review is a comprehensive summary of the most commonly used model organisms of NCDs in which NRF2 has been genetically or pharmacologically modulated, paving the way for drug development to combat NCDs. We discuss the validity and use of these models and identify future challenges.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "NF-E2-Related Factor 2",
+ "Humans",
+ "Animals",
+ "Noncommunicable Diseases",
+ "Oxidative Stress",
+ "Reactive Oxygen Species",
+ "Oxidation-Reduction",
+ "Disease Models, Animal",
+ "Inflammation",
+ "Gene Expression Regulation"
+ ]
+ },
+ {
+ "PMID": "39702198",
+ "Title": "BMC geriatrics",
+ "ArticleTitle": "Age- and sex-disaggregated disease burden among the older persons in India.",
+ "Abstract": "This comprehensive assessment of the differentials in disease burden among older persons across age, sex and states of India, and the gaps identified in the service utilisation data capture by age and sex for the older persons in the national health programs can provide crucial inputs for strengthening the on-going public health policy and programmatic efforts aimed at improving the health and well-being of the growing older population in India.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Aged",
+ "Female",
+ "Male",
+ "India",
+ "Middle Aged",
+ "Aged, 80 and over",
+ "Noncommunicable Diseases",
+ "Cost of Illness",
+ "Disability-Adjusted Life Years",
+ "Sex Factors",
+ "Age Factors",
+ "Global Burden of Disease",
+ "Wounds and Injuries"
+ ]
+ },
+ {
+ "PMID": "39699459",
+ "Title": "Revista brasileira de epidemiologia = Brazilian journal of epidemiology",
+ "ArticleTitle": "Chronic noncommunicable diseases and absenteeism from work: National Survey of Health, 2019.",
+ "Abstract": "The burden of disease and multimorbidity are highly prevalent among employed individuals and are strongly related to absenteeism from work, especially among women. In this sense, workers must be the target of interventions to reduce the impact of chronic noncommunicable diseases.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Absenteeism",
+ "Male",
+ "Female",
+ "Brazil",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Middle Aged",
+ "Chronic Disease",
+ "Noncommunicable Diseases",
+ "Prevalence",
+ "Health Surveys",
+ "Young Adult",
+ "Adolescent",
+ "Sex Distribution",
+ "Socioeconomic Factors",
+ "Cost of Illness",
+ "Multimorbidity",
+ "Sociodemographic Factors"
+ ]
+ },
+ {
+ "PMID": "39697299",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Non-communicable diseases related multimorbidity, catastrophic health expenditure, and associated factors in Ernakulam district.",
+ "Abstract": "The high prevalence of multimorbidity and associated CHE among individuals over 60\u202fyears highlights the urgent need for the National Programme for the Prevention and Control of Non-Communicable Diseases to prioritise multimorbidity and its management, especially above 60 years within this age group.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Multimorbidity",
+ "Noncommunicable Diseases",
+ "Health Expenditures",
+ "Prevalence",
+ "Aged",
+ "Adult",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39696316",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Enhancing multi-sectoral collaborations for the prevention and control of NCDs in Thailand with a new approach.",
+ "Abstract": "This new approach (middle-management oriented), if implemented, may encourage more commitment from the Ministries' representatives, policy-relevant knowledge generation and effective communications between ministries involved in an MSC. Ideally, it would complement the conventional approach (top-management oriented) in enhancing the MSC for controlling NCDs, and thereby bring hope for achieving the NCD-related SDGs for Thailand and possibly other countries as well.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Thailand",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Stakeholder Participation",
+ "Health Policy",
+ "Sustainable Development",
+ "Intersectoral Collaboration",
+ "Cooperative Behavior"
+ ]
+ },
+ {
+ "PMID": "39696309",
+ "Title": "BMC endocrine disorders",
+ "ArticleTitle": "Prevalence of diabetes and its associated factors in Cape Verde: an analysis of the 2020 WHO STEPS survey on non-communicable diseases risk factors.",
+ "Abstract": "Not applicable.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Adult",
+ "Male",
+ "Female",
+ "Diabetes Mellitus, Type 2",
+ "Prevalence",
+ "Aged",
+ "Risk Factors",
+ "Adolescent",
+ "Young Adult",
+ "Cabo Verde",
+ "Prediabetic State",
+ "Noncommunicable Diseases",
+ "World Health Organization",
+ "Cross-Sectional Studies",
+ "Surveys and Questionnaires"
+ ]
+ },
+ {
+ "PMID": "39695503",
+ "Title": "BMC public health",
+ "ArticleTitle": "The relationship between non-communicable disease risk and mental wellbeing in adolescence: a cross-sectional study utilising objective measures in Indonesia.",
+ "Abstract": "Our analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Mental Health"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Indonesia",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Cross-Sectional Studies",
+ "Risk Factors",
+ "Mental Health",
+ "Quality of Life",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39693027",
+ "Title": "Sub-cellular biochemistry",
+ "ArticleTitle": "Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.",
+ "Abstract": "A circadian disruption, manifested by disturbed sleep and low-grade inflammation, is commonly seen in noncommunicable diseases (NCDs). Cardiovascular, respiratory and renal disorders, diabetes and the metabolic syndrome, cancer, and neurodegenerative diseases are among the most common NCDs prevalent in today's 24-h/7\u00a0days Society. The decline in plasma melatonin, which is a conserved phylogenetic molecule across all known aerobic creatures, is a constant feature in NCDs. The daily evening melatonin surge synchronizes both the central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) and myriads of cellular clocks in the periphery (\"chronobiotic effect\"). Melatonin is the prototypical endogenous chronobiotic agent. Several meta-analyses and consensus studies support the use of melatonin to treat sleep/wake cycle disturbances associated with NCDs. Melatonin also has cytoprotective properties, acting primarily not only as an antioxidant by buffering free radicals, but also by regulating inflammation, down-regulating pro-inflammatory cytokines, suppressing low-grade inflammation, and preventing insulin resistance, among other effects. Melatonin's phylogenetic conservation is explained by its versatility of effects. In animal models of NCDs, melatonin treatment prevents a wide range of low-inflammation-linked alterations. As a result, the therapeutic efficacy of melatonin as a chronobiotic/cytoprotective drug has been proposed. Sirtuins 1 and 3 are at the heart of melatonin's chronobiotic and cytoprotective function, acting as accessory components or downstream elements of circadian oscillators and exhibiting properties such as mitochondrial protection. Allometric calculations based on animal research show that melatonin's cytoprotective benefits may require high doses in humans (in the 100\u00a0mg/day range). If melatonin is expected to improve health in NCDs, the low doses currently used in clinical trials (i.e., 2-10\u00a0mg) are unlikely to be beneficial. Multicentre double-blind studies are required to determine the potential utility of melatonin in health promotion. Moreover, melatonin dosage and levels used should be re-evaluated based on preclinical research information.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Melatonin",
+ "Humans",
+ "Animals",
+ "Antioxidants",
+ "Noncommunicable Diseases",
+ "Circadian Rhythm",
+ "Cytoprotection",
+ "Inflammation"
+ ]
+ },
+ {
+ "PMID": "39683555",
+ "Title": "Nutrients",
+ "ArticleTitle": "Risky Behaviors for Non-Communicable Diseases: Italian Adolescents' Food Habits and Physical Activity.",
+ "Abstract": "Many adolescents lead unhealthy lifestyles, but younger adolescents and girls appear to be at higher risk of unhealthy behaviors. Targeted initiatives promoting regular physical activity and balanced diets in schools, involving parents and teachers in a collaborative plan, are essential to improving adolescents' health and well-being.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adolescent",
+ "Male",
+ "Female",
+ "Italy",
+ "Exercise",
+ "Feeding Behavior",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Health Knowledge, Attitudes, Practice",
+ "Young Adult",
+ "Child",
+ "Adolescent Behavior",
+ "Surveys and Questionnaires",
+ "Health Risk Behaviors",
+ "Risk-Taking",
+ "Diet"
+ ]
+ },
+ {
+ "PMID": "39678524",
+ "Title": "Iranian journal of medical sciences",
+ "ArticleTitle": "Clustering the Economic Status via Partitioning around Medoid and Its Association with Common Non-communicable Diseases.",
+ "Abstract": "The findings of the present study showed that economic status was significantly associated with the majority of NCDs.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Iran",
+ "Economic Status",
+ "Cluster Analysis",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39671524",
+ "Title": "American journal of physical medicine & rehabilitation",
+ "ArticleTitle": "Correlation Between Self-reported or Supervised Physical Activity in Noncommunicable Diseases and Comorbidities During COVID-19 Pandemic: A Systematic Review.",
+ "Abstract": "There is evidence that exercise can protect people with noncommunicable diseases during the COVID-19 pandemic.Registration: Registered with Prospero registry.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Exercise",
+ "Comorbidity",
+ "Noncommunicable Diseases",
+ "SARS-CoV-2",
+ "Self Report",
+ "Pandemics"
+ ]
+ },
+ {
+ "PMID": "39662975",
+ "Title": "Global health, science and practice",
+ "ArticleTitle": "Service Delivery Redesign for Noncommunicable Disease Management: Assessment of Needs and Solutions Through a Co-Creation Process in Argentina.",
+ "Abstract": "Our research highlights the potential for Argentina's primary care system to initiate transformative, system-level changes aimed at improving health outcomes. We propose an innovative methodological assessment and co-design for improving primary care.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Argentina",
+ "Noncommunicable Diseases",
+ "Primary Health Care",
+ "Male",
+ "Female",
+ "Cross-Sectional Studies",
+ "Middle Aged",
+ "Delivery of Health Care",
+ "Focus Groups",
+ "Adult",
+ "Aged",
+ "Disease Management",
+ "Health Services Accessibility",
+ "Needs Assessment",
+ "Diabetes Mellitus, Type 2",
+ "Delphi Technique"
+ ]
+ },
+ {
+ "PMID": "39662129",
+ "Title": "Public health",
+ "ArticleTitle": "Non-communicable disease mortality and economic costs attributable to high body mass index in Argentina.",
+ "Abstract": "The burden of NCD mortality and associated economic costs attributable to high BMI in Argentina are substantial, highlighting the urgent need for multi-sectoral interventions to address the increasing prevalence of overweight and obesity.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Argentina",
+ "Body Mass Index",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Adult",
+ "Middle Aged",
+ "Obesity",
+ "Aged",
+ "Cost of Illness",
+ "Risk Assessment",
+ "Overweight"
+ ]
+ },
+ {
+ "PMID": "39658798",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Outcomes of an integrated knowledge translation approach in five African countries: a mixed-methods comparative case study.",
+ "Abstract": "Whilst this study faced many challenges common to the evaluation of knowledge translation interventions, it presents rich, theory-informed insights into IKT outcomes. These are based on documented IKT activities and participants' views, particularly in-depth insights of researchers' experiences with implementing the CEBHA+\u2009IKT approach.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Translational Research, Biomedical",
+ "Humans",
+ "Ethiopia",
+ "Capacity Building",
+ "Decision Making",
+ "Research Personnel",
+ "Public Health",
+ "Malawi",
+ "Uganda",
+ "Noncommunicable Diseases",
+ "Cooperative Behavior",
+ "South Africa",
+ "Delivery of Health Care",
+ "Africa",
+ "Rwanda",
+ "Administrative Personnel",
+ "Focus Groups",
+ "Surveys and Questionnaires",
+ "Evidence-Based Practice",
+ "Qualitative Research",
+ "Health Policy"
+ ]
+ },
+ {
+ "PMID": "39655600",
+ "Title": "Journal of hypertension",
+ "ArticleTitle": "Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients.",
+ "Abstract": "This study did not differentiate host (genetic, molecular, and pathogenic) from environmental drivers of disease. Nonetheless, the findings call for a multipronged and comprehensive implementation of innovative health policies in sub-Saharan countries. Education, research, empowerment of stakeholders, and international learned societies connecting experts from a wide array of disciplines should vigorously sustain this effort.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "White People",
+ "Female",
+ "Male",
+ "Middle Aged",
+ "Aged",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Black People",
+ "Africa South of the Sahara",
+ "Europe",
+ "Renal Insufficiency, Chronic",
+ "Cardiovascular Diseases"
+ ]
+ },
+ {
+ "PMID": "39653570",
+ "Title": "BMJ open",
+ "ArticleTitle": "Exploring symptoms perception and barriers to medication adherence among Thai Muslim patients with non-communicable diseases in a rural community in southern Thailand: a mixed-methods study.",
+ "Abstract": "To improve adherence, healthcare providers should prioritise fostering positive patient-provider relationships and promoting patient care through enhanced health literacy initiatives.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Medication Adherence",
+ "Thailand",
+ "Islam",
+ "Middle Aged",
+ "Noncommunicable Diseases",
+ "Rural Population",
+ "Adult",
+ "Focus Groups",
+ "Qualitative Research",
+ "Aged",
+ "Health Knowledge, Attitudes, Practice",
+ "Southeast Asian People",
+ "Assessment of Medication Adherence"
+ ]
+ },
+ {
+ "PMID": "39653567",
+ "Title": "BMJ open",
+ "ArticleTitle": "Engaging stakeholders in Non-communicable diseases (NCDs) Implementation Research in low- and middle-income countries (LMICs): a scoping review protocol.",
+ "Abstract": "This scoping review protocol is registered on Open Science Framework, with the Digital Object Identifier 10.17605/OSF.IO/ACQ52, ensuring transparency and accountability in the research process.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Developing Countries",
+ "Noncommunicable Diseases",
+ "Research Design",
+ "Stakeholder Participation",
+ "Implementation Science",
+ "Scoping Reviews As Topic"
+ ]
+ },
+ {
+ "PMID": "39645277",
+ "Title": "Best practice & research. Clinical gastroenterology",
+ "ArticleTitle": "The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders.",
+ "Abstract": "Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health. Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led to a significant shift in dietary habits over the past century, with an increased diffusion of the Western diet (WD). WD includes foods high in saturated fat, refined sugars, salt, sweeteners, and low in fiber, and is characterized by overeating, frequent snacking, and a prolonged postprandial state. An increasing body of evidence supports the association between the diffusion of WD and the rising prevalence of NCDs. WD also negatively affects both gut microbiota and the immune system by driving to microbial alterations, gut barrier dysfunction, increased intestinal permeability, and leakage of harmful bacterial metabolites into the bloodstream, with consequent contribution to the development of systemic low-grade inflammation. In this review article we aim to dissect the role of gut microbiota imbalance and gut barrier impairment in mediating the detrimental effects of WD on the development of NCDs, and to identify potential therapeutic strategies.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Chronic Disease",
+ "Diet, Western",
+ "Gastrointestinal Microbiome",
+ "Inflammation",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39644320",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "The problems of functioning of health care system of the Kirghiz Republic and ways of their solving.",
+ "Abstract": "The article presents general analysis of national health care system of the Kirghiz Republic, including particular problems government agencies encounter, role of non-communicable diseases in increasing of total mortality, morbidity and disability of the population. The data is presented concerning economic losses associated with decreasing of labor productivity because of non-communicable diseases morbidity. The priority measures to strengthen primary health care organizations and ways of resolving existing problems in national health care are discussed.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Delivery of Health Care",
+ "Russia",
+ "Primary Health Care",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39644303",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "[The inadequate physical activity as risk factor of non-communicable diseases].",
+ "Abstract": "The article presents brief review of impact of inadequate physical activity on development of non-communicable diseases. The low physical activity is among top five most significant factors of premature death and is the cause of more than 20% of cases of diabetes mellitus II and chronic cardiovascular diseases. The article considers mode of assessing intensity of physical activity based on using metabolic equivalent. The effect of hypodynamia on development of obesity, diseases of musculoskeletal system, diabetes mellitus II, cardio-vascular and oncological diseases is considered. The relationship between inadequate physical activity and population mental health is considered too.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cardiovascular diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Exercise",
+ "Cardiovascular Diseases",
+ "Diabetes Mellitus, Type 2",
+ "Obesity"
+ ]
+ },
+ {
+ "PMID": "39632114",
+ "Title": "BMJ open",
+ "ArticleTitle": "Engaging Australian healthcare consumers to determine priorities and consensus for precision medicine approaches to detect non-communicable disease in early life: a modified Delphi study.",
+ "Abstract": "Our findings indicate the majority (98%) of participants in our study believe early screening for risk of NCD in their children was acceptable, provided it was equitable and clear pathways for referral and support were available.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Delphi Technique",
+ "Precision Medicine",
+ "Noncommunicable Diseases",
+ "Consensus",
+ "Female",
+ "Australia",
+ "Pregnancy",
+ "Adult",
+ "Male",
+ "Mass Screening",
+ "Middle Aged",
+ "Health Priorities"
+ ]
+ },
+ {
+ "PMID": "39625743",
+ "Title": "JMIR research protocols",
+ "ArticleTitle": "Development and Validation of a Novel Tool to Measure Medication Adherence for Noncommunicable Diseases in India: Protocol for an Exploratory Sequential Mixed Methods Multicentric Study.",
+ "Abstract": "PRR1-10.2196/60805.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Noncommunicable Diseases",
+ "Male",
+ "Female",
+ "Surveys and Questionnaires",
+ "Reproducibility of Results",
+ "Multicenter Studies as Topic",
+ "Assessment of Medication Adherence"
+ ]
+ },
+ {
+ "PMID": "39622542",
+ "Title": "BMJ global health",
+ "ArticleTitle": "Food insecurity is associated with greater difficulty accessing care among people living with HIV with or without comorbid non-communicable diseases in western Kenya.",
+ "Abstract": "We found that greater food insecurity was associated with greater difficulty accessing care among PLWH with or without NCDs in rural western Kenya. These findings suggest that addressing social determinants of health may be necessary when implementing integrated HIV and NCD care programmes.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Kenya",
+ "Food Insecurity",
+ "Male",
+ "Female",
+ "HIV Infections",
+ "Adult",
+ "Health Services Accessibility",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Comorbidity",
+ "Young Adult",
+ "Food Supply"
+ ]
+ },
+ {
+ "PMID": "39613439",
+ "Title": "BMJ open",
+ "ArticleTitle": "Prevalence of physical inactivity and associated factors among adults in Eastern African countries: a systematic review and meta-analysis protocol.",
+ "Abstract": "CRD42024567592.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Systematic Reviews as Topic",
+ "Sedentary Behavior",
+ "Meta-Analysis as Topic",
+ "Prevalence",
+ "Risk Factors",
+ "Exercise",
+ "Adult",
+ "Africa, Eastern",
+ "Research Design",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39602608",
+ "Title": "Gaceta medica de Mexico",
+ "ArticleTitle": "Burden of disease in older adults in Mexico, 1990-2022: time trends and challenges for the health system.",
+ "Abstract": "LE-60 increases were not accompanied by reductions in disability due to functional decline, highlighting the need for healthcare strategies to enhance healthy aging.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Mexico",
+ "Cost of Illness",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Disability-Adjusted Life Years",
+ "Healthy Aging",
+ "Mortality",
+ "Life Expectancy",
+ "Prevalence",
+ "Incidence",
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Aged",
+ "Aged, 80 and over",
+ "Delivery of Health Care",
+ "Health Services Needs and Demand"
+ ]
+ },
+ {
+ "PMID": "39595773",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Decentralization Matters: Association of Adherence to Treatment and Distance for the Management of Non-Communicable Diseases in Rural Tanzania.",
+ "Abstract": "Since March 2019, a non-communicable diseases program has been established at hospital level, with enrollment and clinical reassessment every 6 months. Since July 2023, monthly enrollment and visits have also been conducted at health center level. This study aimed at assessing the adherence to scheduled follow-up visits following the decentralization of the integrated NCDs program from Hospital to Health Center level and investigate factors influencing follow-up adherence. The study was performed in a rural district in Iringa Region, Tanzania. Adherence was measured at both levels. Multivariate regression analysis was conducted to describe socio-demographic and clinical factors influencing attendance at the 6-month hospital-level visit. Among 2198 patients enrolled at the hospital level, weighted adherence over 42 months was 40.8% (95% CI 39.0-42.6%) at the 6-month visit. Multivariate analysis revealed that as the distance from the hospital increased, the probability of attendance decreased (OR 0.17; 95% CI: 0.08-0.39). Among 571 patients enrolled at the residence level, adherence over the first 10 months of program implementation was 91.6% (90.4-92.8%). The findings showed that distance was by far the most important barrier to follow-up adherence and suggested that decentralizing the program from the hospital to peripheral health centers may ensure high follow-up rates.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Tanzania",
+ "Humans",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Adult",
+ "Rural Population",
+ "Aged",
+ "Young Adult",
+ "Politics",
+ "Adolescent",
+ "Treatment Adherence and Compliance",
+ "Patient Compliance"
+ ]
+ },
+ {
+ "PMID": "39595772",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Risk Factors for Non-Communicable Diseases in Refugees, Asylum Seekers, and Subsidiary Protection Beneficiaries Resettled or Relocated in Portugal Between 2015 and 2020.",
+ "Abstract": "Non-communicable diseases, previously thought of as a problem of high-income countries, now coexist in low- and middle-income countries, including the countries of origin for many refugees traveling to Europe. We aimed to describe the prevalence of risk factors for non-communicable diseases among refugees, asylum seekers, and subsidiary protection beneficiaries resettled or relocated in Portugal between 2015 and 2020 and compare these to the prevalence of risk factors in the 12 months before they left their country of origin. A cross-sectional study was conducted between 2019 and 2020 of all refugees, asylum seekers, and subsidiary protection beneficiaries attending a Lisbon, Portugal refugee center. Behavioral and biological risk factors were assessed using the WHO STEPwise modified questionnaire. A descriptive statistical analysis was conducted, which included 80 respondents, mainly men, with an average age of of 30.3 \u00b1 9.8 years. The prevalence of several behavioral risk factors for non-communicable diseases among refugees, asylum seekers, and subsidiary protection beneficiaries was higher at the time of the study than in the 12 months before leaving the country of origin. Differences between men and women were noted in tobacco (49.1% vs. 25.9%) and alcohol use (43.4% vs. 18.5%) in the receiving country. Overweight and obesity also showed differences by gender (7.5% vs. 11.1% and 39.6% vs. 48.1%). The prevalence of suicidal ideation and suicidalplanning was high, and varied from 6.3% and 20% in the country of origin to 16.3% and 38.5% respectively in the receiving country, however the prevalence of suicide attempts was lower in the receiving country (66.7%) compared to the country of origin (100.0%). Information on health and social determinants is critical to identify priorities and increase access to access to gender-specific health and community level interventions, including mental health, to reduce risk factors associated with refugee relocation and resettlement.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Refugees",
+ "Male",
+ "Female",
+ "Risk Factors",
+ "Adult",
+ "Portugal",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Young Adult",
+ "Prevalence",
+ "Middle Aged",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39592985",
+ "Title": "BMC public health",
+ "ArticleTitle": "The association between maternal smoking during pregnancy and multimorbidity of non-communicable chronic diseases trajectory in offspring.",
+ "Abstract": "This study suggested that the MSDP is associated with almost all transition phases of MNCDs development and increases the mortality risk of MNCDs in offspring who smoke, and these transition trajectories can be largely reduced by smoking cessation among offspring.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Adult",
+ "Pregnancy",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Prospective Studies",
+ "Adolescent",
+ "Male",
+ "Young Adult",
+ "Aged",
+ "Multimorbidity",
+ "Prenatal Exposure Delayed Effects",
+ "Aged, 80 and over",
+ "Smoking",
+ "Chronic Disease"
+ ]
+ },
+ {
+ "PMID": "39592160",
+ "Title": "BMJ open",
+ "ArticleTitle": "Physical activity interventions implemented for older people in Sub-Saharan Africa: a scoping review.",
+ "Abstract": "This analysis confirms that a structured PA regimen paired with lifestyle education significantly mitigates NCDs in Sub-Saharan Africa's elderly population. Furthermore, it highlights the imperative for further investigation into non-pharmacological strategies, especially those targeting hypertension, diabetes and cognitive health disorders.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Africa South of the Sahara",
+ "Exercise",
+ "Aged",
+ "Noncommunicable Diseases",
+ "Randomized Controlled Trials as Topic",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39589015",
+ "Title": "Epidemiology (Cambridge, Mass.)",
+ "ArticleTitle": "The Contribution of Noncommunicable and Infectious Diseases to the Effect of Depression on Mortality: A Longitudinal Causal Mediation Analysis.",
+ "Abstract": "Within the privately insured population of South Africa, MDD is associated with increased mortality. We found that noncommunicable diseases, rather than infectious diseases, are important mediators of the effect of MDD on mortality.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Male",
+ "Female",
+ "South Africa",
+ "Longitudinal Studies",
+ "Adult",
+ "Middle Aged",
+ "Depressive Disorder, Major",
+ "Communicable Diseases",
+ "Mediation Analysis",
+ "Comorbidity",
+ "Causality",
+ "Aged",
+ "Monte Carlo Method",
+ "Neoplasms",
+ "Cardiovascular Diseases",
+ "Young Adult"
+ ]
+ },
+ {
+ "PMID": "39584432",
+ "Title": "Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit",
+ "ArticleTitle": "Experiences and lessons from using digital technology for noncommunicable disease services during the COVID-19 pandemic in the Eastern Mediterranean Region.",
+ "Abstract": "DHIs for NCD service provision were implemented during the COVID-19 pandemic in all settings: highmiddle-and low-income countries in the EMR. There is a high potential for incorporating DHIs within health systems to increase access to health services beyond the pandemic. Documentation, regulation and national capacity-building for mainstreaming DHIs in public health services in the EMR are strongly encouraged, based on each country's needs.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Noncommunicable Diseases",
+ "Digital Technology",
+ "Middle East",
+ "Telemedicine",
+ "Mediterranean Region",
+ "Pandemics",
+ "SARS-CoV-2",
+ "Delivery of Health Care"
+ ]
+ },
+ {
+ "PMID": "39563350",
+ "Title": "BMC medicine",
+ "ArticleTitle": "Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime.",
+ "Abstract": "Takeaway management zones in England have the potential to meaningfully contribute towards reducing obesity prevalence and associated healthcare burden in the adult population, at the local level and across the rural-urban spectrum.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "England",
+ "Adult",
+ "Male",
+ "Middle Aged",
+ "Schools",
+ "Female",
+ "Obesity",
+ "Public Health",
+ "Fast Foods",
+ "Body Mass Index",
+ "Cross-Sectional Studies",
+ "Health Care Costs",
+ "Restaurants",
+ "Noncommunicable Diseases",
+ "Quality-Adjusted Life Years",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39552939",
+ "Title": "Global heart",
+ "ArticleTitle": "Lessons Learnt from HIV and Noncommunicable Disease Healthcare Integration in Sub-Saharan Africa.",
+ "Abstract": "In sub-Saharan Africa (SSA), a rising burden of noncommunicable diseases (NCDs) coexists with a persistent high burden of human immunodeficiency virus (HIV). Integrating care for chronic conditions is potentially beneficial, but the optimal approach remains unclear. By use of a narrative review of 14 recent case studies from different SSA countries, examples of NCD and HIV healthcare integration were described. Case studies were categorized into three models: integrating NCD care into existing HIV care (",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Africa South of the Sahara",
+ "Noncommunicable Diseases",
+ "HIV Infections",
+ "Delivery of Health Care, Integrated"
+ ]
+ },
+ {
+ "PMID": "39552340",
+ "Title": "Health policy and planning",
+ "ArticleTitle": "Strengthening policy engagement when scaling up interventions targeting non-communicable diseases: insights from a qualitative study across 20 countries.",
+ "Abstract": "Policy engagement is an essential component of implementation research for scaling up interventions targeting non-communicable diseases (NCDs). It refers to the many ways that research team members, implementers and policymakers, who represent government decision-making, connect and interact to explore common interests. Well-conducted engagement activities foster co-production, local contextualization and assist in the successful translation of research evidence into policy and practice. We aimed to identify the challenges and facilitators to policy engagement during the early implementation phase of scale-up research studies. This qualitative study was focused on the research projects that were funded through the Global Alliance for Chronic Diseases in the 2019 round. Nineteen project teams opted to participate, with these studies implemented in 20 countries. Forty-three semi-structured stakeholder interviews, representing research, implementation and government were undertaken between August 2020 and July 2021. Transcripts were open-coded using thematic analysis to extract 63 codes which generated 15 themes reflecting both challenges and facilitators to undertaking policy engagement. Knowledge of the local government structures and trusting relationships provided the foundation for successful engagement and were strengthened by the research. Four cross-cutting concepts for engagement were identified and included: (1) the importance of understanding the policy landscape; (2) facilitating a network of suitable policy champions, (3) providing an environment for policy leaders to genuinely contribute to co-creation and (4) promoting two-way learning during researcher-policymaker engagement. We recommend undertaking formative policy analysis to gain a strategic understanding of the policy landscape and develop targeted engagement plans. Through engagement, researchers must facilitate cohesive vision and build a team of policy champions to advocate NCD research within their networks and spheres of influence. Ensuring equitable partnerships is essential for enabling local ownership and leadership. Further, engagement efforts must create a synergistic policymaker-researcher lens to promote the uptake of evidence into policy.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Noncommunicable Diseases",
+ "Humans",
+ "Qualitative Research",
+ "Health Policy",
+ "Policy Making",
+ "Stakeholder Participation",
+ "Interviews as Topic"
+ ]
+ },
+ {
+ "PMID": "39548534",
+ "Title": "Health research policy and systems",
+ "ArticleTitle": "Implementation of national policies and interventions (WHO Best Buys) for non-communicable disease prevention and control in Ghana: a mixed methods analysis.",
+ "Abstract": "Ghana has made progress in adopting the WHO Best Buys targeting risk factors of NCDs. However, the country faces contextual barriers to effective implementation. With the retrogression of some measures over time despite making progress in some earlier years, further investigation is needed to identify facilitators for sustained implementation of the WHO Best Buys interventions.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Ghana",
+ "Noncommunicable Diseases",
+ "Health Policy",
+ "World Health Organization",
+ "Focus Groups",
+ "Stakeholder Participation",
+ "Policy Making",
+ "Administrative Personnel",
+ "Qualitative Research",
+ "Public Health",
+ "Health Promotion",
+ "Health Plan Implementation"
+ ]
+ },
+ {
+ "PMID": "39541160",
+ "Title": "West African journal of medicine",
+ "ArticleTitle": "INTEGRATION OF MENTAL HEALTH INTO MANAGEMENT OF NON-COMMUNICABLE DISEASES IN PRIMARY CARE: A PROJECT REPORT.",
+ "Abstract": "Integrating mental health into NCD management is essential for improving patient outcomes. This project demonstrates the necessity of such integration in primary care settings, advocating for policy with detailed guidelines for integrating mental health into NCD care in Ghana.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Primary Health Care",
+ "Female",
+ "Male",
+ "Hypertension",
+ "Noncommunicable Diseases",
+ "Diabetes Mellitus, Type 2",
+ "Ghana",
+ "Adult",
+ "Middle Aged",
+ "Delivery of Health Care, Integrated",
+ "Quality Improvement",
+ "Depression",
+ "Mental Health Services",
+ "Anxiety",
+ "Mental Disorders",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39530940",
+ "Title": "Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny",
+ "ArticleTitle": "[STUDY OF PREVENTION STRATEGIES FOR SIX RISK FACTORS IN REDUCING MORTALITY FROM NON-COMMUNICABLE DISEASES 25 \u00d7 25].",
+ "Abstract": "Non-communicable diseases (NCDs) continue to progress against the background of an increase in risk factors and the emergence of new ones, such as postcovid syndrome. Due in part to this influence, the progression of the atherosclerotic process and deterministic cardiovascular diseases is observed. In this regard, the aggravation of NCDs remains alarming against the background of the influence of six leading risk factors \u00ab25 \u00d7 25\u00bb. The article presents a review of the literature and the conceptual directions of these leading factors as dominant in the development of NCDs. The directions of secondary prevention are considered and the expediency of their early implementation is justified. The presented methodological bibliometric method made it possible to analyze the experience of a number of countries that led to a decrease in the development of NCDs. The methods of bibliographic data search included search queries on the Scopus Web of Sciense, MedLine, The Cochrane Lybrary, PubMed databases. It is noted that achieving even six goals with the correction of risk factors will reduce morbidity and mortality from such four major NCDs as cardiovascular diseases, chronic obstructive pulmonary disease, stomach cancer, diabetes mellitus by 2025 to levels close to the target of \u00ab25 \u00d7 25\u00bb, reducing by 77% the gap between the growth situation or stagnation and trends in the growth of new risk factors.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Secondary Prevention"
+ ]
+ },
+ {
+ "PMID": "39522888",
+ "Title": "Ageing research reviews",
+ "ArticleTitle": "Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990-2021: A population-based study.",
+ "Abstract": "The total NCD burden among elderly people in China has been decreasing and changing. Substantial reductions in cardiovascular diseases and chronic respiratory disease have been observed, while rapid increases in mental disorders has also been found. Policies need to be updated to reflect the changing risk landscape. Target interventions should consider age subgroups and sex differences among this population.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "China",
+ "Noncommunicable Diseases",
+ "Aged",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Incidence",
+ "Aged, 80 and over",
+ "Disability-Adjusted Life Years",
+ "Health Priorities",
+ "Global Burden of Disease"
+ ]
+ },
+ {
+ "PMID": "39515219",
+ "Title": "Public health",
+ "ArticleTitle": "Three-year behavioural, health-related quality of life, and body mass index outcomes from the RESPOND randomized trial.",
+ "Abstract": "RESPOND protected overall and psychosocial health and had positive effects on BMIz.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Quality of Life",
+ "Male",
+ "Body Mass Index",
+ "Child",
+ "Female",
+ "Pediatric Obesity",
+ "Victoria",
+ "COVID-19",
+ "Health Behavior",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39514466",
+ "Title": "PloS one",
+ "ArticleTitle": "The role of illness perception in the physical activity domain of health-promoting lifestyle among patients with non-communicable diseases: A systematic review.",
+ "Abstract": "The findings of this review will serve as a guide for healthcare providers in enhancing physical activity adherence among patients with non-communicable diseases through an illness perception approach. This approach can be integrated into clinic consultations and intervention programmes. Future studies are warranted to evaluate the effectiveness of the illness perception approach in promoting physical activity adherence.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Exercise",
+ "Noncommunicable Diseases",
+ "Health Promotion",
+ "Healthy Lifestyle",
+ "Perception",
+ "Life Style"
+ ]
+ },
+ {
+ "PMID": "39511525",
+ "Title": "BMC public health",
+ "ArticleTitle": "Effectiveness of behaviour change techniques in lifestyle interventions for non-communicable diseases: an umbrella review.",
+ "Abstract": "Registered on the International Prospective Register of Systematic Reviews; PROSPERO (CRD42020222832).",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Behavior Therapy",
+ "Health Promotion",
+ "Life Style",
+ "Noncommunicable Diseases",
+ "Systematic Reviews as Topic"
+ ]
+ },
+ {
+ "PMID": "39496368",
+ "Title": "BMJ open",
+ "ArticleTitle": "Socioeconomic inequalities and dyslipidaemia in adult population of the Ravansar Non-Communicable Disease Cohort Study: the role of sex and age.",
+ "Abstract": "The results highlight the existing inequalities in lipid profiles due to SES, sex and age. Consideration of these factors in interventions and policy decisions is critical to reduce abnormalities and inform future interventions.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Dyslipidemias",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Aged",
+ "Prevalence",
+ "Sex Factors",
+ "Socioeconomic Factors",
+ "Noncommunicable Diseases",
+ "Cohort Studies",
+ "Age Factors",
+ "Social Class",
+ "Health Status Disparities",
+ "Risk Factors"
+ ]
+ },
+ {
+ "PMID": "39494478",
+ "Title": "Periodontology 2000",
+ "ArticleTitle": "Periodontal disease: A systemic condition.",
+ "Abstract": "For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in the oral cavity. Initially, associations of periodontitis with a multitude of noncommunicable diseases were each studied separately, and relationships were shown. The associations of periodontitis with morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory diseases, have been demonstrated. As most such studies were cross-sectional in nature, questions about causality cannot be univocally answered. And periodontitis as an independent risk factor for one systemic disease, becomes even more difficult to assess since recently periodontitis has also been associated with multimorbidity. Periodontitis and many systemic diseases share environmental, lifestyle and genetic risk factors, and share immunopathology. Moreover, suffering from one common noncommunicable disease may increase the susceptibility for another such chronic disease; the systemic effects of one condition may be one of various risk factors for another such disease. The overarching effect of any systemic disease is it causing a pro-inflammatory state in the individual; this has also been shown for periodontitis. Moreover, in periodontitis a prothrombotic state and elevated immunological activity have been shown. As such, when we consider periodontal disease as another systemic disease, it can affect the susceptibility and progression of other systemic diseases, and importantly, vice versa. And with this, it is not surprising that periodontitis is associated with a variety of other noncommunicable diseases. The medical definition of a systemic disease includes diseases that affect different organs and systems. Thus, the aim of this opinion paper is to propose that periodontitis should be considered a systemic disease in its own right and that it affects the individual's systemic condition and wellbeing. The dental and medical profession and researchers alike, should adapt this paradigm shift, advancing periodontal disease out of its isolated anatomical location into the total of chronic noncommunicable diseases, being for some conditions a comorbid disease and, vice versa, comorbidities can affect initiation and progression of periodontal disease.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Risk Factors",
+ "Cardiovascular Diseases",
+ "Periodontal Diseases",
+ "Periodontitis",
+ "Disease Susceptibility",
+ "Noncommunicable Diseases",
+ "Comorbidity"
+ ]
+ },
+ {
+ "PMID": "39478581",
+ "Title": "The international journal of behavioral nutrition and physical activity",
+ "ArticleTitle": "Secular trends and sociodemographic disparities in physical activity among adults in eleven African countries: WHO STEPS 2003-2020.",
+ "Abstract": "The prevalence of overall PA among African adults has marginally increased over 17 years. There are still many adults, especially women and people with lower education, not doing well in domain specific PA. Policy and environmental interventions are needed to improve PA and to reduce gender, age, and education disparities in leisure, transport, and occupational PA in African countries.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Adult",
+ "Male",
+ "Exercise",
+ "Female",
+ "Middle Aged",
+ "Young Adult",
+ "Africa",
+ "Adolescent",
+ "Aged",
+ "Socioeconomic Factors",
+ "Noncommunicable Diseases",
+ "Leisure Activities",
+ "Sociodemographic Factors",
+ "Surveys and Questionnaires",
+ "Sex Factors",
+ "Educational Status"
+ ]
+ },
+ {
+ "PMID": "39478517",
+ "Title": "BMC public health",
+ "ArticleTitle": "The association between dietary quality index- international and metabolic risk factors in RaNCD cohort study.",
+ "Abstract": "The study found that participants had poor dietary quality, with some favorable metabolic outcomes in the lowest tertile, but concerning associations in the highest tertile, including increased risk for high triglycerides, blood pressure, and obesity. The complex associations suggest that balanced, multifaceted interventions are needed.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Adult",
+ "Prospective Studies",
+ "Diet",
+ "Risk Factors",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39460821",
+ "Title": "Aging clinical and experimental research",
+ "ArticleTitle": "Disability trends among elderly Ukrainians in war conditions: a 10-year retrospective study.",
+ "Abstract": "Data on primary disability among elderly Ukrainians indicates a significant increase in NCDs-related disability during the war in compare with working population, especially in frontline regions and regions with a high concentration of displaced persons. In this structure of NCDs-related increasing disability, CVD, oncology and musculoskeletal diseases system prevailed.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Ukraine",
+ "Retrospective Studies",
+ "Aged",
+ "Persons with Disabilities",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Aged, 80 and over",
+ "Cardiovascular Diseases",
+ "Armed Conflicts",
+ "Neoplasms",
+ "Eastern European People"
+ ]
+ },
+ {
+ "PMID": "39458499",
+ "Title": "Nutrients",
+ "ArticleTitle": "The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease.",
+ "Abstract": "Because of their liver-protective effects, nutritionists recommend consuming vegetables, fruits, herbs and spices that provide valuable ingredients with anti-inflammatory and anti-cancer effects. These components should be provided with food and, in the case of probiotics, supplementation appears to be important. As a preventive measure, a diet rich in these nutrients is therefore recommended, as well as one that prevents overweight and other diseases that can result in liver disease.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Liver Diseases",
+ "Probiotics",
+ "Chronic Disease",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Dietary Fiber",
+ "Polyphenols",
+ "Food Ingredients",
+ "Diet",
+ "Spices",
+ "Fatty Acids, Omega-3",
+ "Dietary Supplements"
+ ]
+ },
+ {
+ "PMID": "39458490",
+ "Title": "Nutrients",
+ "ArticleTitle": "An Innovative One Health Approach: BIOQUALIM, a Transdisciplinary Research Action Protocol-From Cultivated Biodiversity to Human Health Prevention.",
+ "Abstract": "BIOQUALIM's transdisciplinary approach will demonstrate the PHD's role in preventing NCDs.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biodiversity",
+ "One Health",
+ "Diet, Healthy",
+ "Interdisciplinary Research",
+ "Noncommunicable Diseases",
+ "Diet, Vegetarian",
+ "Neoplasms",
+ "Quality of Life"
+ ]
+ },
+ {
+ "PMID": "39458487",
+ "Title": "Nutrients",
+ "ArticleTitle": "Global Trends and Research Collaborations on Food and Beverages Warning Labels: A Bibliometric Analysis.",
+ "Abstract": "The growth in WL-related research, particularly in Latin America, reflects the increasing implementation of these policies. These results underscore key collaborations and evolving research themes, from food labeling to broader public health impacts, emphasizing the need for continued evaluation of WL effectiveness.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Bibliometrics",
+ "Humans",
+ "Food Labeling",
+ "Beverages",
+ "Global Health",
+ "Nutrition Policy",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39449123",
+ "Title": "BMC medicine",
+ "ArticleTitle": "Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases.",
+ "Abstract": "The dual insights into age-at-disease-onset and gut microbiota composition in disease emphasize the role of certain biomedical and lifestyle factors, e.g., nutrition quality, in disease prevention and management. Understanding these relationships provides a foundation for developing targeted strategies to mitigate the impact of metabolic and inflammatory diseases through lifestyle modifications and gut health management.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Male",
+ "Life Style",
+ "Female",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Diabetes Mellitus, Type 2",
+ "Inflammatory Bowel Diseases",
+ "Adult",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Aged",
+ "Inflammation",
+ "Age of Onset",
+ "Cohort Studies"
+ ]
+ },
+ {
+ "PMID": "39438053",
+ "Title": "BMJ global health",
+ "ArticleTitle": "Maintaining non-communicable disease (NCD) services during the COVID-19 pandemic: lessons from Thailand.",
+ "Abstract": "The COVID-19 pandemic presented a significant challenge to health systems worldwide, requiring resources to be directed to the pandemic response while also maintaining essential health services. Those with non-communicable diseases (NCDs) are particularly vulnerable to COVID-19, and interrupted care resulting from the pandemic has the potential to worsen morbidity and mortality.We used narrative literature review and key informant interviews between August 2021 and June 2022 to identify how NCD services were impacted during the pandemic and which good practices helped support uninterrupted care.On the background of an existing strong healthcare system, Thailand exhibited strong central coordination of the response, minimised funding interruptions and leveraged existing infrastructure to make efficient use of limited resources, such as through mobilising healthcare workforce. A key intervention has been redesigning NCD systems such as through the 'New Normal Medical Services' initiative. This has promoted digital innovations, including remote self-monitoring, patient risk stratification and alternative medication dispensing. Emphasis has been placed on multidisciplinary, patient-centred and community-centred care.NCD service utilisation has been disrupted during the COVID-19 pandemic; however, newly adapted efforts on top of existing robust systems have been critical to mitigating disruptions. Yet challenges remain, including ensuring ongoing evaluation, adaptation and sustainability of redesign initiatives. This learning offers the potential to further positive health systems change on a wider scale, through sharing knowledge, international collaboration and further refinement of the 'new normal' model.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "COVID-19",
+ "Thailand",
+ "Noncommunicable Diseases",
+ "Delivery of Health Care",
+ "SARS-CoV-2",
+ "Pandemics"
+ ]
+ },
+ {
+ "PMID": "39437825",
+ "Title": "Deutsche medizinische Wochenschrift (1946)",
+ "ArticleTitle": "[Migration Medicine: infectious and non-infectious diseases].",
+ "Abstract": "Approximately one third of the German population has a migration background.According to the federal office for migration, in 2022 around 2,7 million people have taken refuge or have immigrated to Germany, causing major challenges for our health system. In this article, important infectious diseases, and non-infectious conditions like hemoglobinopathies are presented. To date, especially the latter are not common in Germany and must therefore move more into focus when taking care of migrants. Furthermore, new treatment options for hemoglobinopathies have been approved in the last couple of years, starting with the introduction of Luspatercept a few years ago for Beta-Thalassemias and in 2023 the introduction of Voxelotor for sickle cell disease. In 2024 the gene therapy with Exagamglogen-Autotemcel using the CRISPR/Cas molecular scissor was authorized as a new promising treatment for both conditions.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Germany",
+ "Communicable Diseases",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39437462",
+ "Title": "Patient education and counseling",
+ "ArticleTitle": "A scoping review of decision regret in non-communicable diseases: The emerging roles of patient-clinician communication, psychological aspects, and medical outcomes.",
+ "Abstract": "Healthcare providers should focus on effective communication and education to personalize care strategies and align treatment decisions with patient expectations. This could ultimately reduce decision regret and improve patient outcomes.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Emotions",
+ "Physician-Patient Relations",
+ "Communication",
+ "Decision Making",
+ "Noncommunicable Diseases",
+ "Informed Consent"
+ ]
+ },
+ {
+ "PMID": "39436669",
+ "Title": "Health policy and planning",
+ "ArticleTitle": "Balancing realist review outputs with the needs of policymakers and practitioners.",
+ "Abstract": "A realist review is a theory-driven approach to synthesizing evidence based on the realist philosophy of science. Realist reviews are conducted to provide the policy and practice community with a rich, detailed and practical understanding of complex social interventions that will likely be of much more use to them when planning and implementing programmes. Robust realist reviews must balance philosophical engagement, methodological rigour and relevance to practice. Nevertheless, they have been criticized for being more philosophically inclined and less methodologically robust, with findings that have little implication for practice. Using the philosophy/epistemology\u2794 methodology\u2794 theory\u2794 practice concept flow, we report how we balanced philosophical principles and practical insights in a recently conducted realist review on participatory practices that impact the benefits of non-communicable disease research and interventions in low- and middle-income countries. If realist reviews are not comprehensible enough for these practitioners, their utility and relevance may suffer from being limited to a specialist cohort of academics. We propose that realist review findings and outputs must be framed and communicated to meaningfully engage practitioners without undertaking translational efforts.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Health Policy",
+ "Policy Making",
+ "Administrative Personnel",
+ "Noncommunicable Diseases",
+ "Developing Countries"
+ ]
+ },
+ {
+ "PMID": "39432502",
+ "Title": "PloS one",
+ "ArticleTitle": "Genetic insights into the connection between pulmonary TB and non-communicable diseases: An integrated analysis of shared genes and potential treatment targets.",
+ "Abstract": "In this study, we found that all of the hub genes are linked with the 10 drug components, and it was observed that aspirin CTD 00005447 was mostly associated with all the other hub genes. This bio-informatics study may help researchers better understand the cause of PTB and its relationship with NCDs, and eventually, this can lead to exploring effective treatment plans.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Tuberculosis, Pulmonary",
+ "Noncommunicable Diseases",
+ "Gene Regulatory Networks",
+ "Lung Neoplasms",
+ "Silicosis",
+ "Protein Interaction Maps",
+ "Renal Insufficiency, Chronic"
+ ]
+ },
+ {
+ "PMID": "39426077",
+ "Title": "Public health",
+ "ArticleTitle": "The cost of obesity and related NCDs in Brazil: An analysis of hospital admissions, disability retirement benefits, and statutory sick pay.",
+ "Abstract": "Obesity prevalence in Brazil implies high direct and indirect costs for the Brazilian government, especially considering circulatory system diseases.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Brazil",
+ "Obesity",
+ "Male",
+ "Female",
+ "Adult",
+ "Middle Aged",
+ "Noncommunicable Diseases",
+ "Hospitalization",
+ "Body Mass Index",
+ "Sick Leave",
+ "Prevalence",
+ "Cost of Illness",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39421825",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Non-communicable diseases in the world over the past century: a secondary data analysis.",
+ "Abstract": "In recent years, nearly all NCDs have shown an increase, yet mortality rates have declined across all regions. Lifestyle can be a major cause of this increase, but advancements in health and medical services, such as screening and treatment, have played a crucial role in improving survival rates.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Prevalence",
+ "Incidence",
+ "Global Health",
+ "Male",
+ "Global Burden of Disease",
+ "Data Analysis",
+ "World Health Organization",
+ "Secondary Data Analysis"
+ ]
+ },
+ {
+ "PMID": "39418781",
+ "Title": "Journal of occupational and environmental medicine",
+ "ArticleTitle": "Developing a Job-Exposure Matrix for Sedentary Behavior: A Study Based on the Inpatient Clinico-Occupational Database of Rosai Hospital Group.",
+ "Abstract": "The job-exposure matrix provides valuable insights into the health impacts of sedentary behavior in the workplace, underscoring significant disease risks associated with prolonged inactivity.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Sedentary Behavior",
+ "Female",
+ "Male",
+ "Case-Control Studies",
+ "Middle Aged",
+ "Adult",
+ "Occupations",
+ "Databases, Factual",
+ "Occupational Exposure",
+ "Risk Factors",
+ "Noncommunicable Diseases",
+ "Myocardial Infarction",
+ "Sitting Position",
+ "Diabetes Mellitus",
+ "Aged",
+ "Workplace"
+ ]
+ },
+ {
+ "PMID": "39418779",
+ "Title": "JMIR public health and surveillance",
+ "ArticleTitle": "Population-Level Distribution, Risk Factors, and Burden of Mortality and Disability-Adjusted Life Years Attributable to Major Noncommunicable Diseases in Western Europe (1990-2021): Ecological Analysis.",
+ "Abstract": "The study findings highlight the substantial burden of NCDs, particularly CVDs and cancer, in Western Europe. This underscores the critical need for targeted interventions and effective implementation of the Action Plan for the Prevention and Control of NCDs to achieve the goal of ensuring healthy lives for all.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Europe",
+ "Female",
+ "Noncommunicable Diseases",
+ "Risk Factors",
+ "Disability-Adjusted Life Years",
+ "Middle Aged",
+ "Aged",
+ "Adult",
+ "Aged, 80 and over",
+ "Adolescent",
+ "Neoplasms",
+ "Cardiovascular Diseases",
+ "Young Adult",
+ "Global Burden of Disease",
+ "Child",
+ "Infant",
+ "Cost of Illness",
+ "Child, Preschool",
+ "Infant, Newborn"
+ ]
+ },
+ {
+ "PMID": "39418251",
+ "Title": "PloS one",
+ "ArticleTitle": "The effect of results-based motivating system on metabolic risk factors of non-communicable diseases: A field trial study.",
+ "Abstract": "Involving non-physician health workers and having action plans based on the health needs of the covered population can decrease obesity and overweight in the community. However, longer trials are needed to observe the effects on hypertension and hyperlipidemia.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Middle Aged",
+ "Female",
+ "Noncommunicable Diseases",
+ "Aged",
+ "Adult",
+ "Obesity",
+ "Hypertension",
+ "Motivation",
+ "Risk Factors",
+ "Hyperlipidemias",
+ "Iran",
+ "Overweight",
+ "Prevalence"
+ ]
+ },
+ {
+ "PMID": "39416942",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Barriers and facilitators to dissemination of non-communicable diseases research: a mixed studies systematic review.",
+ "Abstract": "The protocol of this review was deposited in Open Science Framework (https://doi.org/10.17605/OSF.IO/5QSGD).",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Information Dissemination",
+ "Translational Research, Biomedical"
+ ]
+ },
+ {
+ "PMID": "39411832",
+ "Title": "The British journal of nutrition",
+ "ArticleTitle": "Overview of anti-inflammatory diets and their promising effects on non-communicable diseases.",
+ "Abstract": "An anti-inflammatory diet is characterised by incorporating foods with potential anti-inflammatory properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red and processed meat, refined carbohydrates and saturated fats are limited. This article explores the effects of an anti-inflammatory diet on non-communicable diseases (NCD), concentrating on the underlying mechanisms that connect systemic chronic inflammation, dietary choices and disease outcomes. Chronic inflammation is a pivotal contributor to the initiation and progression of NCD. This review provides an overview of the intricate pathways through which chronic inflammation influences the pathogenesis of conditions including obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer and cognitive disorders. Through a comprehensive synthesis of existing research, we aim to identify some bioactive compounds present in foods deemed anti-inflammatory, explore their capacity to modulate inflammatory pathways and, consequently, to prevent or manage NCD. The findings demonstrated herein contribute to an understanding of the interplay between nutrition, inflammation and chronic diseases, paving a way for future dietary recommendations and research regarding preventive or therapeutic strategies.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Inflammation",
+ "Diet",
+ "Anti-Inflammatory Agents",
+ "Obesity",
+ "Chronic Disease",
+ "Diabetes Mellitus, Type 2",
+ "Fruit"
+ ]
+ },
+ {
+ "PMID": "39408274",
+ "Title": "Nutrients",
+ "ArticleTitle": "An Overview of Apple Varieties and the Importance of Apple Consumption in the Prevention of Non-Communicable Diseases-A Narrative Review.",
+ "Abstract": "Non-communicable diseases such as cardiovascular diseases, cancers, diabetes, and asthma are increasingly common due to factors like industrialization, urbanization, fast-paced life, stress, sedentary lifestyle, and unbalanced diet in the 21st century. These chronic conditions are a global epidemic, being among the top causes of death worldwide. Preventing these diseases through a nutritious diet is crucial, and scientific studies suggest that appropriate fruit intake, particularly apples, can lower the risk of various health issues. Apples, rich in bioactive compounds, vitamins, minerals, and dietary fiber, offer numerous health benefits. Regular consumption of apples helps reduce the risk of atherosclerosis, coronary artery disease, heart attacks, and diabetes, and also provides anti-asthmatic and anti-allergic effects. Apples aid in detoxification, improve digestion, enhance skin, hair, and nail health, and offer protection against cancers, Alzheimer's, and Parkinson's disease. Apples have been a dietary staple for centuries, consumed in various forms like juices, sauces, and ciders. The reviewed article emphasizes the health benefits of apples, highlighting their role in preventing civilization diseases. It also discusses the characteristics of common apple varieties and the impact of thermal processing on their nutritional content.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Malus",
+ "Noncommunicable Diseases",
+ "Fruit",
+ "Nutritive Value",
+ "Diet",
+ "Diet, Healthy"
+ ]
+ },
+ {
+ "PMID": "39408232",
+ "Title": "Nutrients",
+ "ArticleTitle": "Bioactive Natural and Synthetic Products in Human Health and Diseases: Basic, Preclinical and Clinical Studies.",
+ "Abstract": "Since the early 20th century, the increase in non-communicable diseases such as diabetes, heart disease, stroke, and cancer compared to infectious diseases has led to chronic illnesses becoming a leading cause of global morbidity and mortality [...].",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Biological Products",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39407160",
+ "Title": "BMC health services research",
+ "ArticleTitle": "Readiness of the health system to provide non-communicable disease services in Nepal: a comparison between the 2015 and 2021 comprehensive health facility surveys.",
+ "Abstract": "The improvement in NCD service availability does not correspond to the proportional increase in readiness scores, which is crucial for delivering quality care. Regular staff meetings and feedback systems are crucial for improving all services including NCD-related service readiness and should be prioritized by local and provincial governments.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Nepal",
+ "Humans",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Health Services Accessibility",
+ "Health Care Surveys",
+ "Health Facilities",
+ "Female",
+ "Male"
+ ]
+ },
+ {
+ "PMID": "39404094",
+ "Title": "Expert review of cardiovascular therapy",
+ "ArticleTitle": "Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects.",
+ "Abstract": "Due to the fibrinolytic and antithrombotic activity of nattokinase, and more recently added to the anti-inflammatory and antioxidant effects, this enzyme can be used as a new adjuvant therapeutic strategy to mitigate inflammation and oxidative stress in NCDs, including CVD.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Fibrinolytic Agents",
+ "Subtilisins",
+ "Antioxidants",
+ "Oxidative Stress",
+ "Anti-Inflammatory Agents",
+ "Animals",
+ "Inflammation",
+ "Cardiovascular Diseases",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39394102",
+ "Title": "BMC public health",
+ "ArticleTitle": "Recognition of language barriers in comprehending non-communicable disease management among rural elderly people in the DIMAMO surveillance area: a case of AWI-Gen participants.",
+ "Abstract": "The study revealed significant misconceptions about diabetes and hypertension, as well as traditional practices like bloodletting, which were perceived to relieve hypertension symptoms. It also identified critical communication barriers, including limited time for health practitioners to explain diagnoses and treatments. The findings emphasize the need for interpreters and culturally sensitive communication strategies to improve health literacy and care. Collaborative efforts between traditional and western health practitioners are recommended to address these issues and enhance community health interventions.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Communication Barriers",
+ "Aged",
+ "Rural Population",
+ "South Africa",
+ "Middle Aged",
+ "Qualitative Research",
+ "Interviews as Topic",
+ "Health Knowledge, Attitudes, Practice",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39391944",
+ "Title": "The British journal of nutrition",
+ "ArticleTitle": "Patterns of beverages consumption and prevalence of non-communicable chronic diseases.",
+ "Abstract": "Beverages consumption influences diet quality in general and has been associated with the development of non-communicable chronic diseases (NCCD). We aimed to verify the association between beverage consumption patterns and the prevalence of NCCD. A cross-sectional household and population-based study was conducted with 489 individuals aged 20 years and older. The presence of NCCD (arterial hypertension, diabetes, cancer and hypercholesterolemia) was obtained by self-report, while obesity was diagnosed by measuring body weight, height and waist circumference. Beverage consumption patterns were obtained by principal component analysis. The association between beverages patterns and the prevalence of NCCD was verified using Poisson regression, expressed as prevalence ratio (PR) and adjusted for potential confounding factors. Three beverage patterns were identified: \u2018ultra-processed beverages\u2019, \u2018alcoholic beverages\u2019 and \u2018healthy beverages\u2019. Individuals with greater adherence to the Ultra-processed Beverages Pattern had a 2\u00b777 times higher prevalence of cancer (PR: 3\u00b777; 95 % CI 1\u00b757, 9\u00b707). Higher adherence to the Alcoholic Beverages Pattern was associated with a higher prevalence of obesity (PR: 1\u00b797; 95 % CI 1\u00b713, 3\u00b744). In contrast, individuals in the second tertile of adherence to the Healthy Beverages Pattern had a 39 % lower prevalence of hypercholesterolemia (PR: 0\u00b761; 95 % CI 0\u00b740, 0\u00b792), and individuals in the third tertile had a 10 % lower prevalence of abdominal obesity estimated by the waist-to-height ratio (PR: 0\u00b790; 95 % CI 0\u00b783, 0\u00b797). Beverage consumption patterns may be associated with a higher prevalence of NCCD, regardless of other risk factors. It is therefore important to conduct more studies investigating the impact of beverages patterns on health.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Male",
+ "Adult",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Cross-Sectional Studies",
+ "Prevalence",
+ "Chronic Disease",
+ "Beverages",
+ "Obesity",
+ "Aged",
+ "Neoplasms",
+ "Hypercholesterolemia",
+ "Young Adult",
+ "Diet",
+ "Alcoholic Beverages",
+ "Feeding Behavior"
+ ]
+ },
+ {
+ "PMID": "39390457",
+ "Title": "BMC public health",
+ "ArticleTitle": "Examining noncommunicable diseases using satellite imagery: a systematic literature review.",
+ "Abstract": "Researchers have demonstrated they can successfully use satellite imagery data to investigate the world's top NCDs. However, given the rapid increase in satellite technology and artificial intelligence, much of satellite imagery used to address NCDs remains largely untapped. In particular, with most existing studies focusing on high-income countries, future research should use satellite data, to overcome limitations of traditional data, from lower-income countries which have a greater burden of morbidity and mortality from NCDs. Furthermore, creating and refining effective methods to extract and process satellite data may facilitate satellite data's use among scientists studying NCDs worldwide.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Satellite Imagery",
+ "Cardiovascular Diseases",
+ "Neoplasms"
+ ]
+ },
+ {
+ "PMID": "39388415",
+ "Title": "PloS one",
+ "ArticleTitle": "Noncommunicable disease behavioral risk factors in Sub Saharan Africa: A protocol of systematic review and meta-analysis.",
+ "Abstract": "The burden of noncommunicable disease risk factors varies throughout the Sub-Saharan Africa. The review will be essential for both research and policy. The finding may even help to identify settings or subgroups of the population where noncommunicable diseases is of higher concern and help to set prevention priorities, to optimize resource allocation, and guide future research to fill knowledge gaps. The protocol has been registered in PROSPERO (CRD42023431348).",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Africa South of the Sahara",
+ "Alcohol Drinking",
+ "Exercise",
+ "Meta-Analysis as Topic",
+ "Noncommunicable Diseases",
+ "Prevalence",
+ "Risk Factors",
+ "Systematic Reviews as Topic",
+ "Tobacco Use"
+ ]
+ },
+ {
+ "PMID": "39386956",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Non-communicable diseases prevention and control by government ministries in Guyana.",
+ "Abstract": "The results showed limitations in transforming multisectoral initiatives into intersectoral collaboration to achieve real integration among the different actors involved, considering the actual context and content. Actions could be more effectively implemented with significant outcomes for NCD control in Guyana.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Guyana",
+ "Humans",
+ "Noncommunicable Diseases",
+ "Qualitative Research",
+ "Health Policy",
+ "Government",
+ "Policy Making"
+ ]
+ },
+ {
+ "PMID": "39379988",
+ "Title": "BMC medicine",
+ "ArticleTitle": "Association of weight change with all-cause and cause-specific mortality: an age-stratified analysis.",
+ "Abstract": "Weight loss and excessive weight gain were associated with increased risks of mortality among older adults, while only excessive weight loss was associated with increased risks of mortality among middle-aged adults.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Male",
+ "Female",
+ "Aged",
+ "Body Mass Index",
+ "Cardiovascular Diseases",
+ "China",
+ "Neoplasms",
+ "Age Factors",
+ "Cause of Death",
+ "Cohort Studies",
+ "Proportional Hazards Models",
+ "Weight Loss",
+ "Weight Gain",
+ "Risk Factors",
+ "Noncommunicable Diseases"
+ ]
+ },
+ {
+ "PMID": "39374955",
+ "Title": "BMJ (Clinical research ed.)",
+ "ArticleTitle": "Non-communicable diseases: research priorities to mitigate impact of health system shocks.",
+ "Abstract": {
+ "b": "Amitava Banerjee and colleagues"
+ },
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Research",
+ "Health Priorities",
+ "Biomedical Research"
+ ]
+ },
+ {
+ "PMID": "39369417",
+ "Title": "JNMA; journal of the Nepal Medical Association",
+ "ArticleTitle": "Medication Adherence among Patients with Non-Communicable Diseases in a Tertiary Hospital: A Descriptive Cross-sectional Study.",
+ "Abstract": "The study found that less than half of participants fully adhered to prescribed medicine, with forgetfulness identified as a primary cause of non-compliance.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Male",
+ "Cross-Sectional Studies",
+ "Female",
+ "Middle Aged",
+ "Tertiary Care Centers",
+ "Noncommunicable Diseases",
+ "Aged",
+ "Adult",
+ "Nepal",
+ "Health Knowledge, Attitudes, Practice",
+ "Assessment of Medication Adherence"
+ ]
+ },
+ {
+ "PMID": "39369183",
+ "Title": "BMC public health",
+ "ArticleTitle": "How likely are Eastern European and central Asian countries to achieve global NCD targets: multi-country analysis.",
+ "Abstract": "In most Eastern Europe and Central Asia countries, progress towards achieving NCD global targets is slow, or there's a reverse trend. Further quantitative and qualitative research is needed to understand the underlying reasons. Separate indicators are needed to monitor trends for cancers, diabetes and chronic respiratory diseases.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Middle Aged",
+ "Female",
+ "Male",
+ "Aged",
+ "Asia, Central",
+ "Adult",
+ "Europe, Eastern",
+ "Noncommunicable Diseases",
+ "Mortality, Premature",
+ "Global Health",
+ "Global Burden of Disease",
+ "Cardiovascular Diseases",
+ "Neoplasms",
+ "Diabetes Mellitus"
+ ]
+ },
+ {
+ "PMID": "39368120",
+ "Title": "Annals of Saudi medicine",
+ "ArticleTitle": "Estimating the prevalence of select non-communicable diseases in Saudi Arabia using a population-based sample: econometric analysis with natural language processing.",
+ "Abstract": "Retrospective design and reliance on electronic health records, which may not capture all cases of NCDs.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Saudi Arabia",
+ "Middle Aged",
+ "Adult",
+ "Male",
+ "Female",
+ "Noncommunicable Diseases",
+ "Natural Language Processing",
+ "Prevalence",
+ "Retrospective Studies",
+ "Hypertension",
+ "Aged",
+ "Adolescent",
+ "Young Adult",
+ "Diabetes Mellitus",
+ "Electronic Health Records",
+ "Obesity",
+ "Multimorbidity",
+ "Dyslipidemias",
+ "Mental Disorders",
+ "Logistic Models"
+ ]
+ },
+ {
+ "PMID": "39367295",
+ "Title": "BMC primary care",
+ "ArticleTitle": "Performance of health and wellness centre in providing primary care services in Chhattisgarh, India.",
+ "Abstract": "HWCs were able to provide a comprehensive range of primary care services and able to cater to a sizable portion of the rural population's acute and chronic health care needs. The performance was made possible by the adequate availability of medicines, staff, training programmes and tele-consultation linkages. If HWCs in other states are able to reach a similar level of performance, the initiative will prove to be a game changer for equitable primary care in India.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "India",
+ "Humans",
+ "Primary Health Care",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Comprehensive Health Care",
+ "Health Services Needs and Demand"
+ ]
+ },
+ {
+ "PMID": "39365121",
+ "Title": "Indian journal of dental research : official publication of Indian Society for Dental Research",
+ "ArticleTitle": "Dental Research and Noncommunicable Diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Dental Research"
+ ]
+ },
+ {
+ "PMID": "39363978",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Editorial: A gendered approach for accelerating prevention and control of NCDs.",
+ "Abstract": "",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Sex Factors"
+ ]
+ },
+ {
+ "PMID": "39356704",
+ "Title": "PloS one",
+ "ArticleTitle": "Trends and determinants of clustering for non-communicable disease risk factors in women of reproductive age in Nepal.",
+ "Abstract": "Clustering of two or more NCD risk factors was higher among women aged \u226530 years, those who are currently married or widowed/divorced/separated, working women, and individuals from the wealthiest socioeconomic groups. A higher burden of risk factors underscores the importance of targeted public health interventions, particularly among women from advantaged socio-economic groups, those of affluent regions, and in the workplace.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Female",
+ "Adult",
+ "Nepal",
+ "Adolescent",
+ "Middle Aged",
+ "Risk Factors",
+ "Young Adult",
+ "Hypertension",
+ "Obesity",
+ "Smoking",
+ "Prevalence",
+ "Overweight",
+ "Cluster Analysis",
+ "Noncommunicable Diseases",
+ "Health Surveys"
+ ]
+ },
+ {
+ "PMID": "39352154",
+ "Title": "The Medical journal of Malaysia",
+ "ArticleTitle": "Knowledge, attitude and practices of indigenous people towards non-communicable disease in Bera, Malaysia: A community-based study.",
+ "Abstract": "This study presented a low-to-moderate percentage of Orang Asli who have good KAP towards NCD. KAP levels were significantly associated with education levels and household income. Hence, improving education and poverty in the Orang Asli community may successively increase the knowledge level, impart a positive attitude towards NCDs, and improve the practice level toward treatment and prevention.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Malaysia",
+ "Female",
+ "Male",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Health Knowledge, Attitudes, Practice",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Young Adult",
+ "Indigenous Peoples",
+ "Adolescent",
+ "Aged"
+ ]
+ },
+ {
+ "PMID": "39352096",
+ "Title": "Central European journal of public health",
+ "ArticleTitle": "Role of diet in development of non-communicable diseases: focus on gut microbiome.",
+ "Abstract": "Findings from this review emphasize the importance of healthy eating habits in the prevention of intestinal dysbiosis and still increasing prevalence and incidence of obesity and other non-communicable diseases.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes type 2"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Noncommunicable Diseases",
+ "Diet",
+ "Obesity",
+ "Dysbiosis",
+ "Diabetes Mellitus, Type 2",
+ "Czech Republic",
+ "Inflammation"
+ ]
+ },
+ {
+ "PMID": "39344941",
+ "Title": "Community dental health",
+ "ArticleTitle": "Integrating health screening for non-communicable diseases into dental services: what do we know?",
+ "Abstract": "This narrative review describes the impetus for health screening for non-communicable diseases in dental settings and highlights important considerations for evaluating such interventions. Real world cases are presented that showcase health screening interventions implemented in the UK. Non-communicable diseases including diabetes and cardiovascular disease are a global public health challenge. They are largely preventable by implementing lifestyle changes such as healthy eating and participation in physical activity, regular health screening for disease prevention, and/or early initiation of treatment. Hypertension case finding and control is one of the key five areas of focus for adult health, and oral health and diabetes are two of five key clinical areas for children and young people where efforts should be focused to intervene, improve outcomes and reduce inequalities. Links between oral and chronic diseases have been discussed in recent years. Therefore, screening for diabetes and cardiovascular disease has become of greater relevance to the dental profession. There is emerging evidence indicating that screening for the risk factors of cardiovascular diseases and diabetes in dental settings shows promise for improving health outcomes and may offer a cost-effective preventive approach for the detection of diabetes. Real-world services implementing health screening in dental settings have highlighted possibilities for the future and highlight the potential for the role of the dental team in detecting chronic diseases.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Mass Screening",
+ "Cardiovascular Diseases",
+ "Oral Health",
+ "Diabetes Mellitus",
+ "United Kingdom"
+ ]
+ },
+ {
+ "PMID": "39342408",
+ "Title": "Global health research and policy",
+ "ArticleTitle": "The gender gap in outpatient care for non-communicable diseases in Mexico between 2006 and 2022.",
+ "Abstract": "Over 16\u00a0years of outpatient service utilization by Mexican adults requiring care for NCDs has been characterized by the existence of gender inequalities. Women are more likely either not to receive care or resort to using private outpatient services, often resulting in catastrophic out-of-pocket expenses for them and their families. Such inequalities are exacerbated by the segmented structure of the Mexican health system, which provides health insurance conditional on formal employment participation. These findings should be considered as a key factor in reorienting NCD health policies and programs from a gender perspective.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Mexico",
+ "Female",
+ "Male",
+ "Adult",
+ "Middle Aged",
+ "Noncommunicable Diseases",
+ "Ambulatory Care",
+ "Cross-Sectional Studies",
+ "Young Adult",
+ "Aged",
+ "Sex Factors",
+ "Healthcare Disparities"
+ ]
+ },
+ {
+ "PMID": "39342100",
+ "Title": "BMC primary care",
+ "ArticleTitle": "Navigating delayed diagnoses, self-neglect, and lost livelihoods: a qualitative exploration of fisherfolk's health perspectives and management of non-communicable diseases in Kerala, India.",
+ "Abstract": "This study highlights the NCD-related health-seeking experiences of the fisherfolk community in Kerala, India. Fisherfolk reported self neglect, delayed diagnosis, cost and livelihood constraints owing to the onset of NCDs, even as dual practice and medicine access in the public sector were appreciated. Overall, larger studies and policymaking processes should consider in depth the experiences faced by particular economic groups like fisherfolk, who may face unique health and care-seeking challenges.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Qualitative Research",
+ "Fisheries",
+ "Adult",
+ "Middle Aged",
+ "Delayed Diagnosis",
+ "Patient Acceptance of Health Care",
+ "Interviews as Topic",
+ "Aged",
+ "Self Care"
+ ]
+ },
+ {
+ "PMID": "39339734",
+ "Title": "Nutrients",
+ "ArticleTitle": "The Effect of Dietary Types on Gut Microbiota Composition and Development of Non-Communicable Diseases: A Narrative Review.",
+ "Abstract": "The current scientific literature consistently highlights the superiority of plant-based and Mediterranean dietary types over the Western diet in promoting gut health and preventing NCDs. Understanding the influence of diet on gut microbiota modulation may pave the way for novel therapeutic strategies.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Gastrointestinal Microbiome",
+ "Noncommunicable Diseases",
+ "Diet, Mediterranean",
+ "Dysbiosis",
+ "Diet, Western",
+ "Diet, Vegetarian",
+ "Diet",
+ "Methylamines",
+ "Fatty Acids, Volatile"
+ ]
+ },
+ {
+ "PMID": "39338107",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "Beyond Numbers: Decoding the Gendered Tapestry of Non-Communicable Diseases in India.",
+ "Abstract": "The study emphasizes the importance of gender in the prevalence and management of non-communicable diseases (NCDs) in India, advocating for public health strategies that address gender differences, socio-economic factors, and urban-rural disparities to achieve health equity.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "India",
+ "Noncommunicable Diseases",
+ "Male",
+ "Female",
+ "Middle Aged",
+ "Adult",
+ "Aged",
+ "Sex Factors",
+ "Longitudinal Studies",
+ "Young Adult",
+ "Health Surveys",
+ "Prevalence",
+ "Socioeconomic Factors",
+ "Adolescent",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39338026",
+ "Title": "International journal of environmental research and public health",
+ "ArticleTitle": "A Scoping Review of Non-Communicable Diseases among the Workforce as a Threat to Global Peace and Security in Low-Middle Income Countries.",
+ "Abstract": "Non-communicable diseases (NCDs) continue to pose a threat to public health. Although their impact on the workforce is widely recognized, there needs to be more understanding of how NCDs affect peace and security, particularly in low-middle-income countries. To address this, we conducted a scoping review and presented a narrative to explore how NCDs in the workforce threaten peace and security. Out of 570 papers screened, 34 articles, comprising 26 peer review and 8 grey literature, met the study criteria. Our findings reveal that while no study has drawn a direct relationship between NCDs in the workforce in LMICs and peace and security, several studies have demonstrated a relationship between NCDs and economic growth on one hand and economic growth and peace and security on the other. Therefore, using economic growth as a proximal factor, our findings show three pathways that link NCDs in the workforce to peace and security: (i) NCDs lead to low productivity and poor economic growth, which can threaten public peace and security; (ii) NCDs in the workforce can result in long-term care needs, which then puts pressure on public resources and have implications for public expenditure on peace and security; and (iii) household expenditures on caring for a family member with an NCD can destabilize families and create an unfavourable condition that threatens peace and security. This research highlights the dual threat of NCDs to health and security, as they impact human resources and community structures crucial for peace and security. The results underscore the importance of considering the workplace as a strategic setting for NCD prevention, which will have long-term implications for economic growth and peace and security.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Noncommunicable Diseases",
+ "Humans",
+ "Developing Countries",
+ "Economic Development"
+ ]
+ },
+ {
+ "PMID": "39334103",
+ "Title": "BMC health services research",
+ "ArticleTitle": "Examining determinants of control of metabolic syndrome among older adults with NCDs receiving service at NCD Plus clinics: multilevel analysis.",
+ "Abstract": "NCDs Plus clinics that provide complete screening for MetS significantly enhance their effectiveness in reducing the proportion of older adults with MetS. In addition, the service should pay attention to older adults who are female, are retired, and take multiple medications to achieve MetS control better. The insights gained from such an analysis could be instrumental in pinpointing the resources necessary to bolster the efficacy of NCD Plus clinics.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Metabolic Syndrome",
+ "Female",
+ "Male",
+ "Aged",
+ "Cross-Sectional Studies",
+ "Thailand",
+ "Multilevel Analysis",
+ "Noncommunicable Diseases",
+ "Middle Aged",
+ "Aged, 80 and over"
+ ]
+ },
+ {
+ "PMID": "39333314",
+ "Title": "Nature medicine",
+ "ArticleTitle": "The economic value of reducing mortality due to noncommunicable diseases and injuries.",
+ "Abstract": "With population aging, national health systems face difficult trade-offs in allocating resources. The World Bank launched the Healthy Longevity Initiative to generate evidence for investing in policies that can improve healthy longevity and human capital. As part of this initiative, we quantified the economic value of reducing avoidable mortality from major noncommunicable diseases and injuries. We estimated avoidable mortality-the difference between lowest-achieved mortality frontiers and projected mortality trajectories-for each cause of death, for 2000, 2019 and 2050, and for geographic regions, with high-income countries, India and China considered separately; we applied economic values to these estimates. The economic value of reducing cardiovascular disease avoidable mortality would be large for both sexes in all regions, reaching 2-8% of annual income in 2019. For cancers, it would be 5-6% of annual income in high-income countries and China, and for injuries, it would be around 5% in sub-Saharan Africa and Latin America and the Caribbean. Despite the large uncertainty surrounding our estimates, we offer economic values for reducing avoidable mortality by cause and metrics comparable to annual incomes, which enable multisectoral priority setting and are relevant for high-level policy discussions around budget and resource allocations.",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Cancer",
+ "Cardiovascular diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Noncommunicable Diseases",
+ "Wounds and Injuries",
+ "Female",
+ "Male",
+ "Neoplasms",
+ "Cardiovascular Diseases",
+ "Cause of Death",
+ "Global Health"
+ ]
+ },
+ {
+ "PMID": "39324155",
+ "Title": "Frontiers in public health",
+ "ArticleTitle": "Health-promoting behavior and its determinants towards non-communicable diseases among adult residents of the Gedeo zone, South Ethiopia: the application of the health belief model.",
+ "Abstract": "In the study, the mean score of health-promoting behaviors was low. Socio-demographic and economic variables, family history of NCD, perceived health status, knowledge of NCD risk factors, perceived threat, expected outcome, self-efficacy, and cues to action affect health-promoting behaviors. Therefore, the study suggests establishing health promotion programs to increase residents' awareness of health-promoting lifestyles, empower them to adopt healthy lifestyles, and improve health outcomes by increasing self-efficacy, providing education, and creating supportive environments.",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Ethiopia",
+ "Male",
+ "Female",
+ "Adult",
+ "Cross-Sectional Studies",
+ "Noncommunicable Diseases",
+ "Health Belief Model",
+ "Middle Aged",
+ "Health Behavior",
+ "Surveys and Questionnaires",
+ "Health Promotion",
+ "Young Adult",
+ "Health Knowledge, Attitudes, Practice",
+ "Adolescent"
+ ]
+ },
+ {
+ "PMID": "39308827",
+ "Title": "PeerJ",
+ "ArticleTitle": "Effect of PM2.5 on burden of mortality from non-communicable diseases in northern Thailand.",
+ "Abstract": "High PM2.5 risk was observed in March, with peak PM",
+ "Predictions": [
+ "Noncommunicable Diseases",
+ "Diabetes"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Thailand",
+ "Particulate Matter",
+ "Noncommunicable Diseases",
+ "Female",
+ "Male",
+ "Air Pollutants",
+ "Environmental Exposure",
+ "Air Pollution",
+ "Hypertension",
+ "Diabetes Mellitus",
+ "Middle Aged",
+ "Adult"
+ ]
+ },
+ {
+ "PMID": "39307578",
+ "Title": "The Medical journal of Australia",
+ "ArticleTitle": "Pregnancy, childbirth and the postpartum period: opportunities to improve lifetime outcomes for women with non-communicable diseases.",
+ "Abstract": "",
+ "Predictions": [
+ "Noncommunicable Diseases"
+ ],
+ "MeshTerms": [
+ "Humans",
+ "Pregnancy",
+ "Female",
+ "Noncommunicable Diseases",
+ "Postpartum Period",
+ "Parturition",
+ "Pregnancy Complications",
+ "Australia"
+ ]
+ }
+]
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